-- dump date 20140618_222550 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272558000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272558000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272558000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558000004 Walker A motif; other site 272558000005 ATP binding site [chemical binding]; other site 272558000006 Walker B motif; other site 272558000007 arginine finger; other site 272558000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272558000009 DnaA box-binding interface [nucleotide binding]; other site 272558000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 272558000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272558000012 putative DNA binding surface [nucleotide binding]; other site 272558000013 dimer interface [polypeptide binding]; other site 272558000014 beta-clamp/clamp loader binding surface; other site 272558000015 beta-clamp/translesion DNA polymerase binding surface; other site 272558000016 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 272558000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 272558000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272558000019 Walker A/P-loop; other site 272558000020 ATP binding site [chemical binding]; other site 272558000021 Q-loop/lid; other site 272558000022 ABC transporter signature motif; other site 272558000023 Walker B; other site 272558000024 D-loop; other site 272558000025 H-loop/switch region; other site 272558000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272558000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558000028 ATP binding site [chemical binding]; other site 272558000029 Mg2+ binding site [ion binding]; other site 272558000030 G-X-G motif; other site 272558000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272558000032 anchoring element; other site 272558000033 dimer interface [polypeptide binding]; other site 272558000034 ATP binding site [chemical binding]; other site 272558000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272558000036 active site 272558000037 putative metal-binding site [ion binding]; other site 272558000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272558000039 DNA gyrase subunit A; Validated; Region: PRK05560 272558000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272558000041 CAP-like domain; other site 272558000042 active site 272558000043 primary dimer interface [polypeptide binding]; other site 272558000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272558000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558000052 Zn2+ binding site [ion binding]; other site 272558000053 Mg2+ binding site [ion binding]; other site 272558000054 Domain of unknown function (DUF4429); Region: DUF4429; pfam14472 272558000055 Domain of unknown function (DUF4429); Region: DUF4429; pfam14472 272558000056 Short C-terminal domain; Region: SHOCT; pfam09851 272558000057 Phage-related protein [Function unknown]; Region: COG5412 272558000058 putative minor structural protein; Region: PHA01351 272558000059 Phage-related protein [Function unknown]; Region: COG4722 272558000060 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 272558000061 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 272558000062 active site 272558000063 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 272558000064 YaaC-like Protein; Region: YaaC; pfam14175 272558000065 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272558000066 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272558000067 active site 272558000068 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272558000069 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272558000070 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272558000071 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272558000072 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 272558000073 active site 272558000074 multimer interface [polypeptide binding]; other site 272558000075 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 272558000076 predicted active site [active] 272558000077 catalytic triad [active] 272558000078 seryl-tRNA synthetase; Provisional; Region: PRK05431 272558000079 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272558000080 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272558000081 dimer interface [polypeptide binding]; other site 272558000082 active site 272558000083 motif 1; other site 272558000084 motif 2; other site 272558000085 motif 3; other site 272558000086 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 272558000087 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272558000088 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272558000089 active site 272558000090 metal binding site [ion binding]; metal-binding site 272558000091 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272558000092 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 272558000093 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558000094 Walker A/P-loop; other site 272558000095 ATP binding site [chemical binding]; other site 272558000096 Q-loop/lid; other site 272558000097 ABC transporter signature motif; other site 272558000098 Walker B; other site 272558000099 D-loop; other site 272558000100 H-loop/switch region; other site 272558000101 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558000102 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272558000103 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558000104 Walker A/P-loop; other site 272558000105 ATP binding site [chemical binding]; other site 272558000106 Q-loop/lid; other site 272558000107 ABC transporter signature motif; other site 272558000108 Walker B; other site 272558000109 D-loop; other site 272558000110 H-loop/switch region; other site 272558000111 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558000112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272558000113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558000114 dimer interface [polypeptide binding]; other site 272558000115 conserved gate region; other site 272558000116 putative PBP binding loops; other site 272558000117 ABC-ATPase subunit interface; other site 272558000118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272558000119 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272558000120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558000121 dimer interface [polypeptide binding]; other site 272558000122 conserved gate region; other site 272558000123 putative PBP binding loops; other site 272558000124 ABC-ATPase subunit interface; other site 272558000125 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558000126 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 272558000127 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272558000128 nucleoside/Zn binding site; other site 272558000129 dimer interface [polypeptide binding]; other site 272558000130 catalytic motif [active] 272558000131 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272558000132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558000133 Walker A motif; other site 272558000134 ATP binding site [chemical binding]; other site 272558000135 Walker B motif; other site 272558000136 arginine finger; other site 272558000137 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272558000138 hypothetical protein; Validated; Region: PRK00153 272558000139 recombination protein RecR; Reviewed; Region: recR; PRK00076 272558000140 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 272558000141 RecR protein; Region: RecR; pfam02132 272558000142 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272558000143 putative active site [active] 272558000144 putative metal-binding site [ion binding]; other site 272558000145 tetramer interface [polypeptide binding]; other site 272558000146 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 272558000147 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 272558000148 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272558000149 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272558000150 putative active site [active] 272558000151 putative NTP binding site [chemical binding]; other site 272558000152 putative nucleic acid binding site [nucleotide binding]; other site 272558000153 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272558000154 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 272558000155 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272558000156 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272558000157 homodimer interface [polypeptide binding]; other site 272558000158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558000159 catalytic residue [active] 272558000160 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272558000161 thymidylate kinase; Validated; Region: tmk; PRK00698 272558000162 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272558000163 TMP-binding site; other site 272558000164 ATP-binding site [chemical binding]; other site 272558000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 272558000166 DNA polymerase III subunit delta'; Validated; Region: PRK08058 272558000167 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272558000168 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 272558000169 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 272558000170 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272558000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558000172 S-adenosylmethionine binding site [chemical binding]; other site 272558000173 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272558000174 GIY-YIG motif/motif A; other site 272558000175 putative active site [active] 272558000176 putative metal binding site [ion binding]; other site 272558000177 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272558000178 putative SAM binding site [chemical binding]; other site 272558000179 putative homodimer interface [polypeptide binding]; other site 272558000180 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272558000181 NurA domain; Region: NurA; pfam09376 272558000182 HerA helicase [Replication, recombination, and repair]; Region: COG0433 272558000183 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272558000184 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272558000185 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272558000186 active site 272558000187 HIGH motif; other site 272558000188 KMSKS motif; other site 272558000189 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272558000190 tRNA binding surface [nucleotide binding]; other site 272558000191 anticodon binding site; other site 272558000192 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272558000193 dimer interface [polypeptide binding]; other site 272558000194 putative tRNA-binding site [nucleotide binding]; other site 272558000195 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272558000196 active site 272558000197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 272558000198 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272558000199 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272558000200 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272558000201 G5 domain; Region: G5; pfam07501 272558000202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272558000203 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272558000204 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272558000205 putative active site [active] 272558000206 putative metal binding site [ion binding]; other site 272558000207 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272558000208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558000209 S-adenosylmethionine binding site [chemical binding]; other site 272558000210 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 272558000211 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 272558000212 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272558000213 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 272558000214 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272558000215 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272558000216 pur operon repressor; Provisional; Region: PRK09213 272558000217 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272558000218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558000219 active site 272558000220 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272558000221 homotrimer interaction site [polypeptide binding]; other site 272558000222 putative active site [active] 272558000223 regulatory protein SpoVG; Reviewed; Region: PRK13259 272558000224 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272558000225 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272558000226 Substrate binding site; other site 272558000227 Mg++ binding site; other site 272558000228 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272558000229 active site 272558000230 substrate binding site [chemical binding]; other site 272558000231 CoA binding site [chemical binding]; other site 272558000232 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272558000233 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272558000234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558000235 active site 272558000236 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 272558000237 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272558000238 5S rRNA interface [nucleotide binding]; other site 272558000239 CTC domain interface [polypeptide binding]; other site 272558000240 L16 interface [polypeptide binding]; other site 272558000241 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 272558000242 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272558000243 putative active site [active] 272558000244 catalytic residue [active] 272558000245 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272558000246 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272558000247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558000248 ATP binding site [chemical binding]; other site 272558000249 putative Mg++ binding site [ion binding]; other site 272558000250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558000251 nucleotide binding region [chemical binding]; other site 272558000252 ATP-binding site [chemical binding]; other site 272558000253 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272558000254 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272558000255 stage V sporulation protein T; Region: spore_V_T; TIGR02851 272558000256 GAF domain; Region: GAF_2; pfam13185 272558000257 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272558000258 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272558000259 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 272558000260 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 272558000261 putative SAM binding site [chemical binding]; other site 272558000262 putative homodimer interface [polypeptide binding]; other site 272558000263 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272558000264 homodimer interface [polypeptide binding]; other site 272558000265 metal binding site [ion binding]; metal-binding site 272558000266 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272558000267 homodimer interface [polypeptide binding]; other site 272558000268 active site 272558000269 putative chemical substrate binding site [chemical binding]; other site 272558000270 metal binding site [ion binding]; metal-binding site 272558000271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558000272 RNA binding surface [nucleotide binding]; other site 272558000273 sporulation protein YabP; Region: spore_yabP; TIGR02892 272558000274 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 272558000275 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272558000276 hypothetical protein; Provisional; Region: PRK08582 272558000277 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 272558000278 RNA binding site [nucleotide binding]; other site 272558000279 stage II sporulation protein E; Region: spore_II_E; TIGR02865 272558000280 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272558000281 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 272558000282 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272558000283 metal ion-dependent adhesion site (MIDAS); other site 272558000284 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272558000285 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272558000286 active site 272558000287 ATP binding site [chemical binding]; other site 272558000288 substrate binding site [chemical binding]; other site 272558000289 activation loop (A-loop); other site 272558000290 Uncharacterized conserved protein [Function unknown]; Region: COG2966 272558000291 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 272558000292 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 272558000293 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272558000294 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272558000295 Ligand Binding Site [chemical binding]; other site 272558000296 TilS substrate C-terminal domain; Region: TilS_C; smart00977 272558000297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558000298 active site 272558000299 FtsH Extracellular; Region: FtsH_ext; pfam06480 272558000300 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272558000301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558000302 Walker A motif; other site 272558000303 ATP binding site [chemical binding]; other site 272558000304 Walker B motif; other site 272558000305 arginine finger; other site 272558000306 Peptidase family M41; Region: Peptidase_M41; pfam01434 272558000307 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558000308 nucleotide binding site [chemical binding]; other site 272558000309 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272558000310 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272558000311 dimerization interface [polypeptide binding]; other site 272558000312 domain crossover interface; other site 272558000313 redox-dependent activation switch; other site 272558000314 cysteine synthase; Region: PLN02565 272558000315 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272558000316 dimer interface [polypeptide binding]; other site 272558000317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558000318 catalytic residue [active] 272558000319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558000320 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558000321 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558000322 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558000323 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272558000324 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272558000325 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272558000326 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272558000327 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272558000328 glutamine binding [chemical binding]; other site 272558000329 catalytic triad [active] 272558000330 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 272558000331 homodimer interface [polypeptide binding]; other site 272558000332 substrate-cofactor binding pocket; other site 272558000333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558000334 catalytic residue [active] 272558000335 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272558000336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272558000337 substrate binding pocket [chemical binding]; other site 272558000338 dimer interface [polypeptide binding]; other site 272558000339 inhibitor binding site; inhibition site 272558000340 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272558000341 homooctamer interface [polypeptide binding]; other site 272558000342 active site 272558000343 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272558000344 catalytic center binding site [active] 272558000345 ATP binding site [chemical binding]; other site 272558000346 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558000347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558000348 non-specific DNA binding site [nucleotide binding]; other site 272558000349 salt bridge; other site 272558000350 sequence-specific DNA binding site [nucleotide binding]; other site 272558000351 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272558000352 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272558000353 FMN binding site [chemical binding]; other site 272558000354 active site 272558000355 catalytic residues [active] 272558000356 substrate binding site [chemical binding]; other site 272558000357 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272558000358 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272558000359 dimer interface [polypeptide binding]; other site 272558000360 putative anticodon binding site; other site 272558000361 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272558000362 motif 1; other site 272558000363 active site 272558000364 motif 2; other site 272558000365 motif 3; other site 272558000366 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272558000367 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272558000368 putative active site [active] 272558000369 putative NTP binding site [chemical binding]; other site 272558000370 putative nucleic acid binding site [nucleotide binding]; other site 272558000371 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272558000372 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 272558000373 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 272558000374 UvrB/uvrC motif; Region: UVR; pfam02151 272558000375 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 272558000376 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 272558000377 ADP binding site [chemical binding]; other site 272558000378 phosphagen binding site; other site 272558000379 substrate specificity loop; other site 272558000380 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272558000381 Clp amino terminal domain; Region: Clp_N; pfam02861 272558000382 Clp amino terminal domain; Region: Clp_N; pfam02861 272558000383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558000384 Walker A motif; other site 272558000385 ATP binding site [chemical binding]; other site 272558000386 Walker B motif; other site 272558000387 arginine finger; other site 272558000388 UvrB/uvrC motif; Region: UVR; pfam02151 272558000389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558000390 Walker A motif; other site 272558000391 ATP binding site [chemical binding]; other site 272558000392 Walker B motif; other site 272558000393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272558000394 DNA repair protein RadA; Provisional; Region: PRK11823 272558000395 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272558000396 Walker A motif/ATP binding site; other site 272558000397 ATP binding site [chemical binding]; other site 272558000398 Walker B motif; other site 272558000399 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272558000400 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 272558000401 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272558000402 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 272558000403 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272558000404 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 272558000405 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272558000406 putative active site [active] 272558000407 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272558000408 substrate binding site; other site 272558000409 dimer interface; other site 272558000410 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272558000411 homotrimer interaction site [polypeptide binding]; other site 272558000412 zinc binding site [ion binding]; other site 272558000413 CDP-binding sites; other site 272558000414 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272558000415 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272558000416 active site 272558000417 HIGH motif; other site 272558000418 KMSKS motif; other site 272558000419 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272558000420 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272558000421 trimer interface [polypeptide binding]; other site 272558000422 active site 272558000423 substrate binding site [chemical binding]; other site 272558000424 CoA binding site [chemical binding]; other site 272558000425 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 272558000426 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272558000427 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272558000428 active site 272558000429 HIGH motif; other site 272558000430 KMSKS motif; other site 272558000431 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272558000432 tRNA binding surface [nucleotide binding]; other site 272558000433 anticodon binding site; other site 272558000434 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272558000435 active site 272558000436 metal binding site [ion binding]; metal-binding site 272558000437 dimerization interface [polypeptide binding]; other site 272558000438 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272558000439 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272558000440 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272558000441 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 272558000442 RNA polymerase factor sigma-70; Validated; Region: PRK08295 272558000443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558000444 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272558000445 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272558000446 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 272558000447 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272558000448 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272558000449 putative homodimer interface [polypeptide binding]; other site 272558000450 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272558000451 heterodimer interface [polypeptide binding]; other site 272558000452 homodimer interface [polypeptide binding]; other site 272558000453 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272558000454 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272558000455 23S rRNA interface [nucleotide binding]; other site 272558000456 L7/L12 interface [polypeptide binding]; other site 272558000457 putative thiostrepton binding site; other site 272558000458 L25 interface [polypeptide binding]; other site 272558000459 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272558000460 mRNA/rRNA interface [nucleotide binding]; other site 272558000461 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272558000462 23S rRNA interface [nucleotide binding]; other site 272558000463 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272558000464 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272558000465 core dimer interface [polypeptide binding]; other site 272558000466 peripheral dimer interface [polypeptide binding]; other site 272558000467 L10 interface [polypeptide binding]; other site 272558000468 L11 interface [polypeptide binding]; other site 272558000469 putative EF-Tu interaction site [polypeptide binding]; other site 272558000470 putative EF-G interaction site [polypeptide binding]; other site 272558000471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558000472 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558000473 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558000474 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558000475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558000476 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558000477 S-adenosylmethionine binding site [chemical binding]; other site 272558000478 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272558000479 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272558000480 RPB12 interaction site [polypeptide binding]; other site 272558000481 RPB1 interaction site [polypeptide binding]; other site 272558000482 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272558000483 RPB10 interaction site [polypeptide binding]; other site 272558000484 RPB11 interaction site [polypeptide binding]; other site 272558000485 RPB3 interaction site [polypeptide binding]; other site 272558000486 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272558000487 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272558000488 beta and beta' interface [polypeptide binding]; other site 272558000489 beta' and sigma factor interface [polypeptide binding]; other site 272558000490 Zn-binding [ion binding]; other site 272558000491 active site region [active] 272558000492 catalytic site [active] 272558000493 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272558000494 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272558000495 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272558000496 G-loop; other site 272558000497 DNA binding site [nucleotide binding] 272558000498 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 272558000499 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272558000500 S17 interaction site [polypeptide binding]; other site 272558000501 S8 interaction site; other site 272558000502 16S rRNA interaction site [nucleotide binding]; other site 272558000503 streptomycin interaction site [chemical binding]; other site 272558000504 23S rRNA interaction site [nucleotide binding]; other site 272558000505 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272558000506 30S ribosomal protein S7; Validated; Region: PRK05302 272558000507 elongation factor G; Reviewed; Region: PRK00007 272558000508 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272558000509 G1 box; other site 272558000510 putative GEF interaction site [polypeptide binding]; other site 272558000511 GTP/Mg2+ binding site [chemical binding]; other site 272558000512 Switch I region; other site 272558000513 G2 box; other site 272558000514 G3 box; other site 272558000515 Switch II region; other site 272558000516 G4 box; other site 272558000517 G5 box; other site 272558000518 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272558000519 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272558000520 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272558000521 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272558000522 elongation factor Tu; Reviewed; Region: PRK00049 272558000523 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272558000524 G1 box; other site 272558000525 GEF interaction site [polypeptide binding]; other site 272558000526 GTP/Mg2+ binding site [chemical binding]; other site 272558000527 Switch I region; other site 272558000528 G2 box; other site 272558000529 G3 box; other site 272558000530 Switch II region; other site 272558000531 G4 box; other site 272558000532 G5 box; other site 272558000533 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272558000534 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272558000535 Antibiotic Binding Site [chemical binding]; other site 272558000536 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272558000537 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272558000538 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272558000539 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272558000540 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272558000541 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272558000542 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272558000543 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272558000544 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272558000545 putative translocon binding site; other site 272558000546 protein-rRNA interface [nucleotide binding]; other site 272558000547 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272558000548 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272558000549 G-X-X-G motif; other site 272558000550 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272558000551 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272558000552 23S rRNA interface [nucleotide binding]; other site 272558000553 5S rRNA interface [nucleotide binding]; other site 272558000554 putative antibiotic binding site [chemical binding]; other site 272558000555 L25 interface [polypeptide binding]; other site 272558000556 L27 interface [polypeptide binding]; other site 272558000557 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272558000558 23S rRNA interface [nucleotide binding]; other site 272558000559 putative translocon interaction site; other site 272558000560 signal recognition particle (SRP54) interaction site; other site 272558000561 L23 interface [polypeptide binding]; other site 272558000562 trigger factor interaction site; other site 272558000563 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272558000564 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272558000565 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272558000566 RNA binding site [nucleotide binding]; other site 272558000567 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272558000568 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272558000569 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272558000570 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272558000571 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272558000572 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272558000573 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272558000574 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272558000575 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272558000576 5S rRNA interface [nucleotide binding]; other site 272558000577 L27 interface [polypeptide binding]; other site 272558000578 23S rRNA interface [nucleotide binding]; other site 272558000579 L5 interface [polypeptide binding]; other site 272558000580 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272558000581 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272558000582 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272558000583 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272558000584 23S rRNA binding site [nucleotide binding]; other site 272558000585 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272558000586 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272558000587 SecY translocase; Region: SecY; pfam00344 272558000588 adenylate kinase; Reviewed; Region: adk; PRK00279 272558000589 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272558000590 AMP-binding site [chemical binding]; other site 272558000591 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272558000592 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272558000593 active site 272558000594 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 272558000595 RNA binding site [nucleotide binding]; other site 272558000596 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272558000597 rRNA binding site [nucleotide binding]; other site 272558000598 predicted 30S ribosome binding site; other site 272558000599 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272558000600 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272558000601 30S ribosomal protein S11; Validated; Region: PRK05309 272558000602 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272558000603 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272558000604 alphaNTD homodimer interface [polypeptide binding]; other site 272558000605 alphaNTD - beta interaction site [polypeptide binding]; other site 272558000606 alphaNTD - beta' interaction site [polypeptide binding]; other site 272558000607 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272558000608 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272558000609 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 272558000610 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272558000611 Walker A/P-loop; other site 272558000612 ATP binding site [chemical binding]; other site 272558000613 Q-loop/lid; other site 272558000614 ABC transporter signature motif; other site 272558000615 Walker B; other site 272558000616 D-loop; other site 272558000617 H-loop/switch region; other site 272558000618 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 272558000619 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272558000620 Walker A/P-loop; other site 272558000621 ATP binding site [chemical binding]; other site 272558000622 Q-loop/lid; other site 272558000623 ABC transporter signature motif; other site 272558000624 Walker B; other site 272558000625 D-loop; other site 272558000626 H-loop/switch region; other site 272558000627 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272558000628 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272558000629 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272558000630 dimerization interface 3.5A [polypeptide binding]; other site 272558000631 active site 272558000632 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272558000633 23S rRNA interface [nucleotide binding]; other site 272558000634 L3 interface [polypeptide binding]; other site 272558000635 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272558000636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272558000637 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272558000638 substrate binding pocket [chemical binding]; other site 272558000639 membrane-bound complex binding site; other site 272558000640 hinge residues; other site 272558000641 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272558000642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558000643 dimer interface [polypeptide binding]; other site 272558000644 conserved gate region; other site 272558000645 putative PBP binding loops; other site 272558000646 ABC-ATPase subunit interface; other site 272558000647 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272558000648 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272558000649 Walker A/P-loop; other site 272558000650 ATP binding site [chemical binding]; other site 272558000651 Q-loop/lid; other site 272558000652 ABC transporter signature motif; other site 272558000653 Walker B; other site 272558000654 D-loop; other site 272558000655 H-loop/switch region; other site 272558000656 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 272558000657 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 272558000658 trimer interface [polypeptide binding]; other site 272558000659 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 272558000660 trimer interface [polypeptide binding]; other site 272558000661 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 272558000662 trimer interface [polypeptide binding]; other site 272558000663 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 272558000664 trimer interface [polypeptide binding]; other site 272558000665 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 272558000666 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558000667 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 272558000668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558000669 Walker A/P-loop; other site 272558000670 ATP binding site [chemical binding]; other site 272558000671 Q-loop/lid; other site 272558000672 ABC transporter signature motif; other site 272558000673 Walker B; other site 272558000674 D-loop; other site 272558000675 H-loop/switch region; other site 272558000676 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272558000677 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272558000678 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272558000679 putative active site [active] 272558000680 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272558000681 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272558000682 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272558000683 NAD binding site [chemical binding]; other site 272558000684 sugar binding site [chemical binding]; other site 272558000685 divalent metal binding site [ion binding]; other site 272558000686 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272558000687 dimer interface [polypeptide binding]; other site 272558000688 hypothetical protein; Provisional; Region: PRK08204 272558000689 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558000690 active site 272558000691 DinB superfamily; Region: DinB_2; pfam12867 272558000692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272558000693 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 272558000694 putative NAD(P) binding site [chemical binding]; other site 272558000695 catalytic Zn binding site [ion binding]; other site 272558000696 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272558000697 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 272558000698 putative NAD(P) binding site [chemical binding]; other site 272558000699 catalytic Zn binding site [ion binding]; other site 272558000700 structural Zn binding site [ion binding]; other site 272558000701 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 272558000702 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 272558000703 active site 272558000704 P-loop; other site 272558000705 phosphorylation site [posttranslational modification] 272558000706 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272558000707 active site 272558000708 phosphorylation site [posttranslational modification] 272558000709 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272558000710 Mga helix-turn-helix domain; Region: Mga; pfam05043 272558000711 PRD domain; Region: PRD; pfam00874 272558000712 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272558000713 active site 272558000714 P-loop; other site 272558000715 phosphorylation site [posttranslational modification] 272558000716 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272558000717 active site 272558000718 phosphorylation site [posttranslational modification] 272558000719 PaaX-like protein; Region: PaaX; pfam07848 272558000720 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 272558000721 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 272558000722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272558000723 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 272558000724 acyl-activating enzyme (AAE) consensus motif; other site 272558000725 AMP binding site [chemical binding]; other site 272558000726 active site 272558000727 CoA binding site [chemical binding]; other site 272558000728 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 272558000729 Uncharacterized enzyme of phenylacetate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3460 272558000730 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 272558000731 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272558000732 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 272558000733 conserved hypothetical protein; Region: TIGR02118 272558000734 enoyl-CoA hydratase; Provisional; Region: PRK05862 272558000735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558000736 substrate binding site [chemical binding]; other site 272558000737 oxyanion hole (OAH) forming residues; other site 272558000738 trimer interface [polypeptide binding]; other site 272558000739 enoyl-CoA hydratase; Provisional; Region: PRK08140 272558000740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558000741 substrate binding site [chemical binding]; other site 272558000742 oxyanion hole (OAH) forming residues; other site 272558000743 trimer interface [polypeptide binding]; other site 272558000744 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272558000745 NAD(P) binding site [chemical binding]; other site 272558000746 catalytic residues [active] 272558000747 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 272558000748 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272558000749 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272558000750 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 272558000751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272558000752 dimer interface [polypeptide binding]; other site 272558000753 active site 272558000754 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272558000755 subunit interaction site [polypeptide binding]; other site 272558000756 PHB binding site; other site 272558000757 CoenzymeA binding site [chemical binding]; other site 272558000758 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 272558000759 enoyl-CoA hydratase; Provisional; Region: PRK07657 272558000760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558000761 substrate binding site [chemical binding]; other site 272558000762 oxyanion hole (OAH) forming residues; other site 272558000763 trimer interface [polypeptide binding]; other site 272558000764 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272558000765 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272558000766 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272558000767 FMN binding site [chemical binding]; other site 272558000768 substrate binding site [chemical binding]; other site 272558000769 putative catalytic residue [active] 272558000770 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272558000771 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272558000772 trimer interface [polypeptide binding]; other site 272558000773 putative metal binding site [ion binding]; other site 272558000774 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558000775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558000776 putative DNA binding site [nucleotide binding]; other site 272558000777 putative Zn2+ binding site [ion binding]; other site 272558000778 AsnC family; Region: AsnC_trans_reg; pfam01037 272558000779 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272558000780 TPP-binding site [chemical binding]; other site 272558000781 tetramer interface [polypeptide binding]; other site 272558000782 heterodimer interface [polypeptide binding]; other site 272558000783 phosphorylation loop region [posttranslational modification] 272558000784 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272558000785 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272558000786 alpha subunit interface [polypeptide binding]; other site 272558000787 TPP binding site [chemical binding]; other site 272558000788 heterodimer interface [polypeptide binding]; other site 272558000789 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558000790 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272558000791 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272558000792 E3 interaction surface; other site 272558000793 lipoyl attachment site [posttranslational modification]; other site 272558000794 e3 binding domain; Region: E3_binding; pfam02817 272558000795 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558000796 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 272558000797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558000798 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272558000799 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 272558000800 Na2 binding site [ion binding]; other site 272558000801 putative substrate binding site 1 [chemical binding]; other site 272558000802 Na binding site 1 [ion binding]; other site 272558000803 putative substrate binding site 2 [chemical binding]; other site 272558000804 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272558000805 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558000806 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 272558000807 NAD binding site [chemical binding]; other site 272558000808 Phe binding site; other site 272558000809 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 272558000810 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272558000811 HTH domain; Region: HTH_11; pfam08279 272558000812 PRD domain; Region: PRD; pfam00874 272558000813 PRD domain; Region: PRD; pfam00874 272558000814 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272558000815 active site 272558000816 P-loop; other site 272558000817 phosphorylation site [posttranslational modification] 272558000818 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272558000819 active site 272558000820 phosphorylation site [posttranslational modification] 272558000821 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272558000822 active site 272558000823 phosphorylation site [posttranslational modification] 272558000824 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272558000825 active site 272558000826 P-loop; other site 272558000827 phosphorylation site [posttranslational modification] 272558000828 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272558000829 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272558000830 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272558000831 putative active site [active] 272558000832 putative NTP binding site [chemical binding]; other site 272558000833 putative nucleic acid binding site [nucleotide binding]; other site 272558000834 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272558000835 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 272558000836 active site 272558000837 substrate binding pocket [chemical binding]; other site 272558000838 homodimer interaction site [polypeptide binding]; other site 272558000839 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 272558000840 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272558000841 putative active site [active] 272558000842 Uncharacterized conserved protein [Function unknown]; Region: COG2461 272558000843 Family of unknown function (DUF438); Region: DUF438; pfam04282 272558000844 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272558000845 ligand binding site [chemical binding]; other site 272558000846 flexible hinge region; other site 272558000847 YwiC-like protein; Region: YwiC; pfam14256 272558000848 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272558000849 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 272558000850 ligand binding site [chemical binding]; other site 272558000851 flexible hinge region; other site 272558000852 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272558000853 putative switch regulator; other site 272558000854 non-specific DNA interactions [nucleotide binding]; other site 272558000855 DNA binding site [nucleotide binding] 272558000856 sequence specific DNA binding site [nucleotide binding]; other site 272558000857 putative cAMP binding site [chemical binding]; other site 272558000858 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 272558000859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558000860 Uncharacterized conserved protein [Function unknown]; Region: COG5460 272558000861 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272558000862 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272558000863 Predicted glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: ACF2; COG5498 272558000864 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 272558000865 metal binding site [ion binding]; metal-binding site 272558000866 ligand binding site [chemical binding]; other site 272558000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558000868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558000869 putative substrate translocation pore; other site 272558000870 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 272558000871 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558000872 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558000873 active site 272558000874 metal binding site [ion binding]; metal-binding site 272558000875 Domain of unknown function DUF59; Region: DUF59; pfam01883 272558000876 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 272558000877 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272558000878 Walker A motif; other site 272558000879 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 272558000880 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272558000881 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 272558000882 NodB motif; other site 272558000883 putative active site [active] 272558000884 putative catalytic site [active] 272558000885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558000886 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558000887 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558000888 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558000889 Haemolysin XhlA; Region: XhlA; pfam10779 272558000890 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 272558000891 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272558000892 Walker A/P-loop; other site 272558000893 ATP binding site [chemical binding]; other site 272558000894 Q-loop/lid; other site 272558000895 ABC transporter signature motif; other site 272558000896 Walker B; other site 272558000897 D-loop; other site 272558000898 H-loop/switch region; other site 272558000899 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 272558000900 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272558000901 Walker A/P-loop; other site 272558000902 ATP binding site [chemical binding]; other site 272558000903 Q-loop/lid; other site 272558000904 ABC transporter signature motif; other site 272558000905 Walker B; other site 272558000906 D-loop; other site 272558000907 H-loop/switch region; other site 272558000908 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272558000909 TM-ABC transporter signature motif; other site 272558000910 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272558000911 TM-ABC transporter signature motif; other site 272558000912 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 272558000913 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 272558000914 putative ligand binding site [chemical binding]; other site 272558000915 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272558000916 alpha-gamma subunit interface [polypeptide binding]; other site 272558000917 beta-gamma subunit interface [polypeptide binding]; other site 272558000918 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 272558000919 gamma-beta subunit interface [polypeptide binding]; other site 272558000920 alpha-beta subunit interface [polypeptide binding]; other site 272558000921 urease subunit alpha; Reviewed; Region: ureC; PRK13207 272558000922 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272558000923 subunit interactions [polypeptide binding]; other site 272558000924 active site 272558000925 flap region; other site 272558000926 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 272558000927 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 272558000928 dimer interface [polypeptide binding]; other site 272558000929 catalytic residues [active] 272558000930 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 272558000931 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272558000932 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 272558000933 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272558000934 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272558000935 metal binding site [ion binding]; metal-binding site 272558000936 putative transposase; Provisional; Region: PRK09857 272558000937 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 272558000938 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 272558000939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558000940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558000941 DNA binding residues [nucleotide binding] 272558000942 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 272558000943 Putative zinc-finger; Region: zf-HC2; pfam13490 272558000944 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 272558000945 Protein of unknown function (DUF342); Region: DUF342; cl19219 272558000946 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272558000947 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272558000948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 272558000949 YbbR-like protein; Region: YbbR; pfam07949 272558000950 YbbR-like protein; Region: YbbR; pfam07949 272558000951 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272558000952 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272558000953 active site 272558000954 substrate binding site [chemical binding]; other site 272558000955 metal binding site [ion binding]; metal-binding site 272558000956 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272558000957 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272558000958 glutaminase active site [active] 272558000959 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272558000960 dimer interface [polypeptide binding]; other site 272558000961 active site 272558000962 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272558000963 dimer interface [polypeptide binding]; other site 272558000964 active site 272558000965 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558000966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558000967 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558000968 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558000969 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558000970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558000971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558000972 active site 272558000973 phosphorylation site [posttranslational modification] 272558000974 intermolecular recognition site; other site 272558000975 dimerization interface [polypeptide binding]; other site 272558000976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558000977 DNA binding site [nucleotide binding] 272558000978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558000979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558000980 ATP binding site [chemical binding]; other site 272558000981 Mg2+ binding site [ion binding]; other site 272558000982 G-X-G motif; other site 272558000983 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558000984 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558000985 Walker A/P-loop; other site 272558000986 ATP binding site [chemical binding]; other site 272558000987 Q-loop/lid; other site 272558000988 ABC transporter signature motif; other site 272558000989 Walker B; other site 272558000990 D-loop; other site 272558000991 H-loop/switch region; other site 272558000992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558000993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558000994 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558000995 FtsX-like permease family; Region: FtsX; pfam02687 272558000996 metal-dependent hydrolase; Provisional; Region: PRK13291 272558000997 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 272558000998 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 272558000999 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558001000 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272558001001 Walker A/P-loop; other site 272558001002 ATP binding site [chemical binding]; other site 272558001003 Q-loop/lid; other site 272558001004 ABC transporter signature motif; other site 272558001005 Walker B; other site 272558001006 D-loop; other site 272558001007 H-loop/switch region; other site 272558001008 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272558001009 active site 272558001010 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272558001011 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272558001012 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272558001013 active site pocket [active] 272558001014 putative dimer interface [polypeptide binding]; other site 272558001015 putative cataytic base [active] 272558001016 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272558001017 catalytic core [active] 272558001018 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558001019 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558001020 Walker A/P-loop; other site 272558001021 ATP binding site [chemical binding]; other site 272558001022 Q-loop/lid; other site 272558001023 ABC transporter signature motif; other site 272558001024 Walker B; other site 272558001025 D-loop; other site 272558001026 H-loop/switch region; other site 272558001027 FtsX-like permease family; Region: FtsX; pfam02687 272558001028 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272558001029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558001031 active site 272558001032 phosphorylation site [posttranslational modification] 272558001033 intermolecular recognition site; other site 272558001034 dimerization interface [polypeptide binding]; other site 272558001035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558001036 DNA binding site [nucleotide binding] 272558001037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558001038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001039 ATP binding site [chemical binding]; other site 272558001040 Mg2+ binding site [ion binding]; other site 272558001041 G-X-G motif; other site 272558001042 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558001043 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558001044 Walker A/P-loop; other site 272558001045 ATP binding site [chemical binding]; other site 272558001046 Q-loop/lid; other site 272558001047 ABC transporter signature motif; other site 272558001048 Walker B; other site 272558001049 D-loop; other site 272558001050 H-loop/switch region; other site 272558001051 Acyltransferase family; Region: Acyl_transf_3; cl19154 272558001052 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558001053 putative DNA binding site [nucleotide binding]; other site 272558001054 dimerization interface [polypeptide binding]; other site 272558001055 putative Zn2+ binding site [ion binding]; other site 272558001056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558001057 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558001058 putative substrate translocation pore; other site 272558001059 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272558001060 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558001061 active site turn [active] 272558001062 phosphorylation site [posttranslational modification] 272558001063 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558001064 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272558001065 HPr interaction site; other site 272558001066 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272558001067 active site 272558001068 phosphorylation site [posttranslational modification] 272558001069 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272558001070 CAT RNA binding domain; Region: CAT_RBD; smart01061 272558001071 PRD domain; Region: PRD; pfam00874 272558001072 PRD domain; Region: PRD; pfam00874 272558001073 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558001074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001075 Coenzyme A binding pocket [chemical binding]; other site 272558001076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558001077 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 272558001078 putative FMN binding site [chemical binding]; other site 272558001079 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272558001080 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272558001081 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 272558001082 NADP binding site [chemical binding]; other site 272558001083 Predicted transcriptional regulator [Transcription]; Region: COG1959 272558001084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558001085 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558001086 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 272558001087 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272558001088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272558001089 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272558001090 Walker A/P-loop; other site 272558001091 ATP binding site [chemical binding]; other site 272558001092 Q-loop/lid; other site 272558001093 ABC transporter signature motif; other site 272558001094 Walker B; other site 272558001095 D-loop; other site 272558001096 H-loop/switch region; other site 272558001097 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272558001098 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 272558001099 putative NAD(P) binding site [chemical binding]; other site 272558001100 active site 272558001101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558001102 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272558001103 DinB superfamily; Region: DinB_2; pfam12867 272558001104 uridine kinase; Provisional; Region: PRK07667 272558001105 active site 272558001106 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 272558001107 Phosphotransferase enzyme family; Region: APH; pfam01636 272558001108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272558001109 active site 272558001110 substrate binding site [chemical binding]; other site 272558001111 ATP binding site [chemical binding]; other site 272558001112 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cd09657 272558001113 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 272558001114 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 272558001115 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09656 272558001116 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682 272558001117 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09654 272558001118 CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661 272558001119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272558001120 Transposase; Region: HTH_Tnp_1; cl17663 272558001121 putative transposase OrfB; Reviewed; Region: PHA02517 272558001122 HTH-like domain; Region: HTH_21; pfam13276 272558001123 Integrase core domain; Region: rve; pfam00665 272558001124 Integrase core domain; Region: rve_3; pfam13683 272558001125 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 272558001126 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 272558001127 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 272558001128 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 272558001129 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642 272558001130 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 272558001131 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 272558001132 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 272558001133 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 272558001134 similar to hypothetical protein 272558001135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558001136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558001137 non-specific DNA binding site [nucleotide binding]; other site 272558001138 salt bridge; other site 272558001139 sequence-specific DNA binding site [nucleotide binding]; other site 272558001140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558001141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558001142 non-specific DNA binding site [nucleotide binding]; other site 272558001143 salt bridge; other site 272558001144 sequence-specific DNA binding site [nucleotide binding]; other site 272558001145 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558001146 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 272558001147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272558001148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001149 dimer interface [polypeptide binding]; other site 272558001150 conserved gate region; other site 272558001151 putative PBP binding loops; other site 272558001152 ABC-ATPase subunit interface; other site 272558001153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272558001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001155 dimer interface [polypeptide binding]; other site 272558001156 conserved gate region; other site 272558001157 putative PBP binding loops; other site 272558001158 ABC-ATPase subunit interface; other site 272558001159 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272558001160 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558001161 Walker A/P-loop; other site 272558001162 ATP binding site [chemical binding]; other site 272558001163 Q-loop/lid; other site 272558001164 ABC transporter signature motif; other site 272558001165 Walker B; other site 272558001166 D-loop; other site 272558001167 H-loop/switch region; other site 272558001168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558001169 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 272558001170 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558001171 Walker A/P-loop; other site 272558001172 ATP binding site [chemical binding]; other site 272558001173 Q-loop/lid; other site 272558001174 ABC transporter signature motif; other site 272558001175 Walker B; other site 272558001176 D-loop; other site 272558001177 H-loop/switch region; other site 272558001178 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558001179 glutamate carboxypeptidase; Reviewed; Region: PRK06133 272558001180 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 272558001181 metal binding site [ion binding]; metal-binding site 272558001182 dimer interface [polypeptide binding]; other site 272558001183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558001184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558001185 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272558001186 Putative methyltransferase; Region: Methyltransf_4; cl17290 272558001187 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558001188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558001189 S-adenosylmethionine binding site [chemical binding]; other site 272558001190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558001191 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558001192 Predicted membrane protein [Function unknown]; Region: COG2311 272558001193 Protein of unknown function (DUF418); Region: DUF418; pfam04235 272558001194 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 272558001195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272558001196 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 272558001197 active site 272558001198 zinc binding site [ion binding]; other site 272558001199 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272558001200 Collagen binding domain; Region: Collagen_bind; pfam05737 272558001201 Collagen binding domain; Region: Collagen_bind; pfam05737 272558001202 Collagen binding domain; Region: Collagen_bind; pfam05737 272558001203 Cna protein B-type domain; Region: Cna_B; pfam05738 272558001204 Cna protein B-type domain; Region: Cna_B; pfam05738 272558001205 Cna protein B-type domain; Region: Cna_B; pfam05738 272558001206 Cna protein B-type domain; Region: Cna_B; pfam05738 272558001207 Cna protein B-type domain; Region: Cna_B; pfam05738 272558001208 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 272558001209 active site 272558001210 catalytic site [active] 272558001211 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272558001212 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272558001213 NAD(P) binding site [chemical binding]; other site 272558001214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558001215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558001216 non-specific DNA binding site [nucleotide binding]; other site 272558001217 salt bridge; other site 272558001218 sequence-specific DNA binding site [nucleotide binding]; other site 272558001219 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272558001220 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272558001221 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272558001222 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272558001223 dimer interface [polypeptide binding]; other site 272558001224 [2Fe-2S] cluster binding site [ion binding]; other site 272558001225 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272558001226 trimer interface [polypeptide binding]; other site 272558001227 active site 272558001228 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272558001229 trimerization site [polypeptide binding]; other site 272558001230 active site 272558001231 Cupin domain; Region: Cupin_2; pfam07883 272558001232 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272558001233 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 272558001234 active site 272558001235 Zn binding site [ion binding]; other site 272558001236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558001237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558001238 active site 272558001239 phosphorylation site [posttranslational modification] 272558001240 intermolecular recognition site; other site 272558001241 dimerization interface [polypeptide binding]; other site 272558001242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558001243 DNA binding site [nucleotide binding] 272558001244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558001245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558001246 dimerization interface [polypeptide binding]; other site 272558001247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558001248 dimer interface [polypeptide binding]; other site 272558001249 phosphorylation site [posttranslational modification] 272558001250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001251 ATP binding site [chemical binding]; other site 272558001252 Mg2+ binding site [ion binding]; other site 272558001253 G-X-G motif; other site 272558001254 Predicted membrane protein [Function unknown]; Region: COG3212 272558001255 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272558001256 Predicted membrane protein [Function unknown]; Region: COG3212 272558001257 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272558001258 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272558001259 MutS domain III; Region: MutS_III; pfam05192 272558001260 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 272558001261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558001262 Walker A/P-loop; other site 272558001263 ATP binding site [chemical binding]; other site 272558001264 Q-loop/lid; other site 272558001265 ABC transporter signature motif; other site 272558001266 Walker B; other site 272558001267 D-loop; other site 272558001268 H-loop/switch region; other site 272558001269 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 272558001270 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 272558001271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558001272 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558001273 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558001274 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558001275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558001276 S-adenosylmethionine binding site [chemical binding]; other site 272558001277 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 272558001278 Phosphotransferase enzyme family; Region: APH; pfam01636 272558001279 putative active site [active] 272558001280 putative substrate binding site [chemical binding]; other site 272558001281 ATP binding site [chemical binding]; other site 272558001282 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558001283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558001284 Walker A/P-loop; other site 272558001285 ATP binding site [chemical binding]; other site 272558001286 Q-loop/lid; other site 272558001287 ABC transporter signature motif; other site 272558001288 Walker B; other site 272558001289 D-loop; other site 272558001290 H-loop/switch region; other site 272558001291 Predicted transcriptional regulators [Transcription]; Region: COG1725 272558001292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558001293 DNA-binding site [nucleotide binding]; DNA binding site 272558001294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001295 Coenzyme A binding pocket [chemical binding]; other site 272558001296 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558001297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558001298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558001299 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558001300 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558001301 EamA-like transporter family; Region: EamA; pfam00892 272558001302 EamA-like transporter family; Region: EamA; pfam00892 272558001303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558001304 dimerization interface [polypeptide binding]; other site 272558001305 putative DNA binding site [nucleotide binding]; other site 272558001306 putative Zn2+ binding site [ion binding]; other site 272558001307 Winged helix-turn-helix; Region: HTH_45; cl01362 272558001308 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272558001309 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272558001310 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272558001311 DNA binding site [nucleotide binding] 272558001312 active site 272558001313 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272558001314 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272558001315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001317 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 272558001318 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558001319 EamA-like transporter family; Region: EamA; pfam00892 272558001320 EamA-like transporter family; Region: EamA; pfam00892 272558001321 sensory histidine kinase DcuS; Provisional; Region: PRK11086 272558001322 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 272558001323 PAS domain; Region: PAS; smart00091 272558001324 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 272558001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001326 ATP binding site [chemical binding]; other site 272558001327 Mg2+ binding site [ion binding]; other site 272558001328 G-X-G motif; other site 272558001329 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 272558001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558001331 active site 272558001332 phosphorylation site [posttranslational modification] 272558001333 intermolecular recognition site; other site 272558001334 dimerization interface [polypeptide binding]; other site 272558001335 HTH domain; Region: HTH_11; cl17392 272558001336 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 272558001337 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272558001338 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272558001339 putative NAD(P) binding site [chemical binding]; other site 272558001340 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 272558001341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558001343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001344 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 272558001345 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272558001346 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 272558001347 dimer interface [polypeptide binding]; other site 272558001348 FMN binding site [chemical binding]; other site 272558001349 Predicted transcriptional regulators [Transcription]; Region: COG1695 272558001350 hypothetical protein; Validated; Region: PRK07668 272558001351 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558001352 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272558001353 DNA binding residues [nucleotide binding] 272558001354 dimer interface [polypeptide binding]; other site 272558001355 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 272558001356 50S ribosomal protein L11; Region: L11_bact; TIGR01632 272558001357 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272558001358 23S rRNA interface [nucleotide binding]; other site 272558001359 L7/L12 interface [polypeptide binding]; other site 272558001360 putative thiostrepton binding site; other site 272558001361 L25 interface [polypeptide binding]; other site 272558001362 short chain dehydrogenase; Provisional; Region: PRK08303 272558001363 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272558001364 NAD(P) binding site [chemical binding]; other site 272558001365 active site 272558001366 Predicted transcriptional regulator [Transcription]; Region: COG2378 272558001367 HTH domain; Region: HTH_11; pfam08279 272558001368 WYL domain; Region: WYL; pfam13280 272558001369 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 272558001370 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272558001371 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 272558001372 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272558001373 active site 272558001374 active site 272558001375 catalytic site [active] 272558001376 Carbohydrate binding domain; Region: CBM_25; smart01066 272558001377 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272558001378 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272558001379 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272558001380 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272558001381 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272558001382 Ligand Binding Site [chemical binding]; other site 272558001383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558001384 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558001385 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558001386 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558001387 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 272558001388 active site 272558001389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558001390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558001391 S-adenosylmethionine binding site [chemical binding]; other site 272558001392 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272558001393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558001394 DNA-binding site [nucleotide binding]; DNA binding site 272558001395 UTRA domain; Region: UTRA; pfam07702 272558001396 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272558001397 active site 272558001398 trimer interface [polypeptide binding]; other site 272558001399 allosteric site; other site 272558001400 active site lid [active] 272558001401 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272558001402 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272558001403 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272558001404 active site 272558001405 dimer interface [polypeptide binding]; other site 272558001406 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 272558001407 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558001408 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558001409 active site turn [active] 272558001410 phosphorylation site [posttranslational modification] 272558001411 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558001412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558001413 putative DNA binding site [nucleotide binding]; other site 272558001414 putative Zn2+ binding site [ion binding]; other site 272558001415 AsnC family; Region: AsnC_trans_reg; pfam01037 272558001416 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272558001417 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558001418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001419 Coenzyme A binding pocket [chemical binding]; other site 272558001420 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 272558001421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558001422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558001423 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272558001424 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272558001425 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 272558001426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558001427 motif II; other site 272558001428 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 272558001429 Lysine efflux permease [General function prediction only]; Region: COG1279 272558001430 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272558001431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558001432 DNA-binding site [nucleotide binding]; DNA binding site 272558001433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558001434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558001435 homodimer interface [polypeptide binding]; other site 272558001436 catalytic residue [active] 272558001437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272558001438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558001440 Coenzyme A binding pocket [chemical binding]; other site 272558001441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558001442 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558001443 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558001444 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 272558001445 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 272558001446 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272558001447 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 272558001448 THF binding site; other site 272558001449 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272558001450 substrate binding site [chemical binding]; other site 272558001451 THF binding site; other site 272558001452 zinc-binding site [ion binding]; other site 272558001453 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272558001454 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 272558001455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272558001456 substrate binding pocket [chemical binding]; other site 272558001457 membrane-bound complex binding site; other site 272558001458 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272558001459 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272558001460 Walker A/P-loop; other site 272558001461 ATP binding site [chemical binding]; other site 272558001462 Q-loop/lid; other site 272558001463 ABC transporter signature motif; other site 272558001464 Walker B; other site 272558001465 D-loop; other site 272558001466 H-loop/switch region; other site 272558001467 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272558001468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001469 dimer interface [polypeptide binding]; other site 272558001470 conserved gate region; other site 272558001471 putative PBP binding loops; other site 272558001472 ABC-ATPase subunit interface; other site 272558001473 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272558001474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001475 dimer interface [polypeptide binding]; other site 272558001476 conserved gate region; other site 272558001477 putative PBP binding loops; other site 272558001478 ABC-ATPase subunit interface; other site 272558001479 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558001480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001481 Coenzyme A binding pocket [chemical binding]; other site 272558001482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558001483 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558001484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558001485 Walker A/P-loop; other site 272558001486 ATP binding site [chemical binding]; other site 272558001487 Q-loop/lid; other site 272558001488 ABC transporter signature motif; other site 272558001489 Walker B; other site 272558001490 D-loop; other site 272558001491 H-loop/switch region; other site 272558001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 272558001493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 272558001494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558001495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558001496 Walker A/P-loop; other site 272558001497 ATP binding site [chemical binding]; other site 272558001498 Q-loop/lid; other site 272558001499 ABC transporter signature motif; other site 272558001500 Walker B; other site 272558001501 D-loop; other site 272558001502 H-loop/switch region; other site 272558001503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 272558001504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 272558001505 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272558001506 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 272558001507 putative active site [active] 272558001508 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558001509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558001510 Walker A/P-loop; other site 272558001511 ATP binding site [chemical binding]; other site 272558001512 Q-loop/lid; other site 272558001513 ABC transporter signature motif; other site 272558001514 Walker B; other site 272558001515 D-loop; other site 272558001516 H-loop/switch region; other site 272558001517 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 272558001518 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 272558001519 active site 272558001520 zinc binding site [ion binding]; other site 272558001521 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 272558001522 Lantibiotic alpha; Region: Lantibiotic_a; pfam14867 272558001523 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 272558001524 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 272558001525 active site 272558001526 zinc binding site [ion binding]; other site 272558001527 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558001528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558001529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558001530 non-specific DNA binding site [nucleotide binding]; other site 272558001531 salt bridge; other site 272558001532 sequence-specific DNA binding site [nucleotide binding]; other site 272558001533 PilZ domain; Region: PilZ; pfam07238 272558001534 Uncharacterized conserved protein [Function unknown]; Region: COG3339 272558001535 Domain of unknown function DUF20; Region: UPF0118; cl00465 272558001536 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 272558001537 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 272558001538 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272558001539 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272558001540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272558001541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001542 Coenzyme A binding pocket [chemical binding]; other site 272558001543 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272558001544 TrkA-N domain; Region: TrkA_N; pfam02254 272558001545 TrkA-C domain; Region: TrkA_C; pfam02080 272558001546 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272558001547 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 272558001548 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 272558001549 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272558001550 Walker A/P-loop; other site 272558001551 ATP binding site [chemical binding]; other site 272558001552 Q-loop/lid; other site 272558001553 ABC transporter signature motif; other site 272558001554 Walker B; other site 272558001555 D-loop; other site 272558001556 H-loop/switch region; other site 272558001557 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272558001558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001559 dimer interface [polypeptide binding]; other site 272558001560 conserved gate region; other site 272558001561 putative PBP binding loops; other site 272558001562 ABC-ATPase subunit interface; other site 272558001563 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272558001564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558001565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558001566 putative substrate translocation pore; other site 272558001567 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272558001568 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 272558001569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558001570 motif II; other site 272558001571 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272558001572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272558001573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272558001574 active site 272558001575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558001576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001577 Coenzyme A binding pocket [chemical binding]; other site 272558001578 Tetratrico peptide repeat; Region: TPR_5; pfam12688 272558001579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558001580 binding surface 272558001581 TPR motif; other site 272558001582 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272558001583 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272558001584 putative dimer interface [polypeptide binding]; other site 272558001585 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558001586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001587 dimer interface [polypeptide binding]; other site 272558001588 conserved gate region; other site 272558001589 putative PBP binding loops; other site 272558001590 ABC-ATPase subunit interface; other site 272558001591 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558001592 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558001593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001594 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558001595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001597 dimer interface [polypeptide binding]; other site 272558001598 conserved gate region; other site 272558001599 ABC-ATPase subunit interface; other site 272558001600 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 272558001601 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558001602 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558001603 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558001604 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558001605 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272558001606 galactarate dehydratase; Region: galactar-dH20; TIGR03248 272558001607 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 272558001608 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 272558001609 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272558001610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272558001611 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272558001612 active site 272558001613 altronate oxidoreductase; Provisional; Region: PRK03643 272558001614 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272558001615 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272558001616 Glucuronate isomerase; Region: UxaC; pfam02614 272558001617 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272558001618 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272558001619 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272558001620 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272558001621 Right handed beta helix region; Region: Beta_helix; pfam13229 272558001622 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 272558001623 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272558001624 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272558001625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558001626 active site 272558001627 motif I; other site 272558001628 motif II; other site 272558001629 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558001630 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 272558001631 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787 272558001632 Restriction endonuclease; Region: Mrr_cat; pfam04471 272558001633 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272558001634 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272558001635 ADP binding site [chemical binding]; other site 272558001636 magnesium binding site [ion binding]; other site 272558001637 putative shikimate binding site; other site 272558001638 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 272558001639 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272558001640 active site 272558001641 dimer interface [polypeptide binding]; other site 272558001642 catalytic residues [active] 272558001643 effector binding site; other site 272558001644 R2 peptide binding site; other site 272558001645 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272558001646 dimer interface [polypeptide binding]; other site 272558001647 putative radical transfer pathway; other site 272558001648 diiron center [ion binding]; other site 272558001649 tyrosyl radical; other site 272558001650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558001651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001652 Coenzyme A binding pocket [chemical binding]; other site 272558001653 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 272558001654 heme-binding site [chemical binding]; other site 272558001655 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558001656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558001657 dimer interface [polypeptide binding]; other site 272558001658 putative CheW interface [polypeptide binding]; other site 272558001659 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 272558001660 classical (c) SDRs; Region: SDR_c; cd05233 272558001661 NAD(P) binding site [chemical binding]; other site 272558001662 active site 272558001663 Predicted transcriptional regulators [Transcription]; Region: COG1733 272558001664 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 272558001665 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272558001666 MgtE intracellular N domain; Region: MgtE_N; pfam03448 272558001667 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272558001668 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272558001669 Divalent cation transporter; Region: MgtE; pfam01769 272558001670 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272558001671 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 272558001672 Walker A/P-loop; other site 272558001673 ATP binding site [chemical binding]; other site 272558001674 Q-loop/lid; other site 272558001675 ABC transporter signature motif; other site 272558001676 Walker B; other site 272558001677 D-loop; other site 272558001678 H-loop/switch region; other site 272558001679 TOBE domain; Region: TOBE_2; pfam08402 272558001680 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272558001681 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272558001682 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272558001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001684 dimer interface [polypeptide binding]; other site 272558001685 conserved gate region; other site 272558001686 putative PBP binding loops; other site 272558001687 ABC-ATPase subunit interface; other site 272558001688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001689 dimer interface [polypeptide binding]; other site 272558001690 conserved gate region; other site 272558001691 putative PBP binding loops; other site 272558001692 ABC-ATPase subunit interface; other site 272558001693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 272558001694 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272558001695 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272558001696 metal binding site [ion binding]; metal-binding site 272558001697 Rhomboid family; Region: Rhomboid; pfam01694 272558001698 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272558001699 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 272558001700 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 272558001701 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272558001702 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272558001703 active site 272558001704 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272558001705 dimer interface [polypeptide binding]; other site 272558001706 substrate binding site [chemical binding]; other site 272558001707 catalytic residues [active] 272558001708 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 272558001709 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 272558001710 Rsbr N terminal; Region: Rsbr_N; pfam08678 272558001711 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272558001712 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272558001713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558001714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001715 ATP binding site [chemical binding]; other site 272558001716 Mg2+ binding site [ion binding]; other site 272558001717 G-X-G motif; other site 272558001718 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272558001719 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 272558001720 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272558001721 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272558001722 anti sigma factor interaction site; other site 272558001723 regulatory phosphorylation site [posttranslational modification]; other site 272558001724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001725 ATP binding site [chemical binding]; other site 272558001726 Mg2+ binding site [ion binding]; other site 272558001727 G-X-G motif; other site 272558001728 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 272558001729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558001730 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272558001731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558001732 DNA binding residues [nucleotide binding] 272558001733 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272558001734 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272558001735 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272558001736 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272558001737 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272558001738 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272558001739 RNA binding site [nucleotide binding]; other site 272558001740 hypothetical protein; Provisional; Region: PRK04351 272558001741 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272558001742 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272558001743 putative active site [active] 272558001744 putative NTP binding site [chemical binding]; other site 272558001745 putative nucleic acid binding site [nucleotide binding]; other site 272558001746 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272558001747 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 272558001748 putative active site [active] 272558001749 metal binding site [ion binding]; metal-binding site 272558001750 GAF domain; Region: GAF_3; pfam13492 272558001751 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272558001752 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 272558001753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558001754 dimer interface [polypeptide binding]; other site 272558001755 phosphorylation site [posttranslational modification] 272558001756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001757 ATP binding site [chemical binding]; other site 272558001758 Mg2+ binding site [ion binding]; other site 272558001759 G-X-G motif; other site 272558001760 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272558001761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558001762 active site 272558001763 phosphorylation site [posttranslational modification] 272558001764 intermolecular recognition site; other site 272558001765 dimerization interface [polypeptide binding]; other site 272558001766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558001767 Walker A motif; other site 272558001768 ATP binding site [chemical binding]; other site 272558001769 Walker B motif; other site 272558001770 arginine finger; other site 272558001771 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558001772 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272558001773 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272558001774 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 272558001775 NAD(P) binding site [chemical binding]; other site 272558001776 catalytic residues [active] 272558001777 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272558001778 MgtC family; Region: MgtC; pfam02308 272558001779 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272558001780 homodimer interface [polypeptide binding]; other site 272558001781 substrate-cofactor binding pocket; other site 272558001782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558001783 catalytic residue [active] 272558001784 thiamine-monophosphate kinase; Region: thiL; TIGR01379 272558001785 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272558001786 ATP binding site [chemical binding]; other site 272558001787 dimerization interface [polypeptide binding]; other site 272558001788 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272558001789 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272558001790 Glycoprotease family; Region: Peptidase_M22; pfam00814 272558001791 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272558001792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558001793 Coenzyme A binding pocket [chemical binding]; other site 272558001794 UGMP family protein; Validated; Region: PRK09604 272558001795 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272558001796 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272558001797 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272558001798 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272558001799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558001800 ABC transporter; Region: ABC_tran_2; pfam12848 272558001801 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272558001802 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 272558001803 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272558001804 CoA binding domain; Region: CoA_binding; pfam02629 272558001805 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 272558001806 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272558001807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558001808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558001809 putative substrate translocation pore; other site 272558001810 glycerate kinase; Region: TIGR00045 272558001811 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272558001812 metal-binding site [ion binding] 272558001813 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272558001814 metal-binding site [ion binding] 272558001815 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272558001816 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272558001817 metal-binding site [ion binding] 272558001818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272558001819 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272558001820 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 272558001821 putative homodimer interface [polypeptide binding]; other site 272558001822 putative homotetramer interface [polypeptide binding]; other site 272558001823 putative allosteric switch controlling residues; other site 272558001824 putative metal binding site [ion binding]; other site 272558001825 putative homodimer-homodimer interface [polypeptide binding]; other site 272558001826 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 272558001827 CAAX protease self-immunity; Region: Abi; pfam02517 272558001828 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272558001829 oligomerisation interface [polypeptide binding]; other site 272558001830 mobile loop; other site 272558001831 roof hairpin; other site 272558001832 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272558001833 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272558001834 ring oligomerisation interface [polypeptide binding]; other site 272558001835 ATP/Mg binding site [chemical binding]; other site 272558001836 stacking interactions; other site 272558001837 hinge regions; other site 272558001838 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558001839 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558001840 dimer interface [polypeptide binding]; other site 272558001841 putative CheW interface [polypeptide binding]; other site 272558001842 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 272558001843 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558001844 catalytic residue [active] 272558001845 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558001846 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 272558001847 substrate binding site [chemical binding]; other site 272558001848 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 272558001849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001850 dimer interface [polypeptide binding]; other site 272558001851 conserved gate region; other site 272558001852 putative PBP binding loops; other site 272558001853 ABC-ATPase subunit interface; other site 272558001854 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272558001855 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 272558001856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558001857 dimer interface [polypeptide binding]; other site 272558001858 conserved gate region; other site 272558001859 putative PBP binding loops; other site 272558001860 ABC-ATPase subunit interface; other site 272558001861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558001862 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 272558001863 Walker A/P-loop; other site 272558001864 ATP binding site [chemical binding]; other site 272558001865 Q-loop/lid; other site 272558001866 ABC transporter signature motif; other site 272558001867 Walker B; other site 272558001868 D-loop; other site 272558001869 H-loop/switch region; other site 272558001870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558001871 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 272558001872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558001873 Walker A/P-loop; other site 272558001874 ATP binding site [chemical binding]; other site 272558001875 Q-loop/lid; other site 272558001876 ABC transporter signature motif; other site 272558001877 Walker B; other site 272558001878 D-loop; other site 272558001879 H-loop/switch region; other site 272558001880 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272558001881 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 272558001882 Chromate transporter; Region: Chromate_transp; pfam02417 272558001883 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272558001884 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 272558001885 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272558001886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558001887 DNA-binding site [nucleotide binding]; DNA binding site 272558001888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558001889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558001890 homodimer interface [polypeptide binding]; other site 272558001891 catalytic residue [active] 272558001892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272558001893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558001894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558001895 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558001896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558001897 active site 272558001898 phosphorylation site [posttranslational modification] 272558001899 intermolecular recognition site; other site 272558001900 dimerization interface [polypeptide binding]; other site 272558001901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558001902 DNA binding residues [nucleotide binding] 272558001903 dimerization interface [polypeptide binding]; other site 272558001904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558001905 YwiC-like protein; Region: YwiC; pfam14256 272558001906 Histidine kinase; Region: HisKA_3; pfam07730 272558001907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558001908 ATP binding site [chemical binding]; other site 272558001909 Mg2+ binding site [ion binding]; other site 272558001910 G-X-G motif; other site 272558001911 Predicted membrane protein [Function unknown]; Region: COG2311 272558001912 Protein of unknown function (DUF418); Region: DUF418; pfam04235 272558001913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558001914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558001915 Helix-turn-helix domain; Region: HTH_41; pfam14502 272558001916 DNA-binding site [nucleotide binding]; DNA binding site 272558001917 YhfZ C-terminal domain; Region: YhfZ_C; pfam14503 272558001918 PRD domain; Region: PRD; pfam00874 272558001919 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 272558001920 Protein of unknown function; Region: YhfT; pfam10797 272558001921 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 272558001922 active site 272558001923 substrate binding pocket [chemical binding]; other site 272558001924 homodimer interaction site [polypeptide binding]; other site 272558001925 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272558001926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558001927 catalytic residue [active] 272558001928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 272558001929 dimer interface [polypeptide binding]; other site 272558001930 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 272558001931 active site 272558001932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272558001933 substrate binding site [chemical binding]; other site 272558001934 catalytic residue [active] 272558001935 putative mutase; Provisional; Region: PRK12383 272558001936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558001938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558001939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558001940 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 272558001941 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558001942 active site turn [active] 272558001943 phosphorylation site [posttranslational modification] 272558001944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558001945 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272558001946 HPr interaction site; other site 272558001947 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272558001948 active site 272558001949 phosphorylation site [posttranslational modification] 272558001950 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272558001951 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272558001952 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272558001953 TrkA-N domain; Region: TrkA_N; pfam02254 272558001954 TrkA-C domain; Region: TrkA_C; pfam02080 272558001955 Cation transport protein; Region: TrkH; cl17365 272558001956 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 272558001957 Cation transport protein; Region: TrkH; pfam02386 272558001958 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558001959 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558001960 Walker A/P-loop; other site 272558001961 ATP binding site [chemical binding]; other site 272558001962 Q-loop/lid; other site 272558001963 ABC transporter signature motif; other site 272558001964 Walker B; other site 272558001965 D-loop; other site 272558001966 H-loop/switch region; other site 272558001967 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272558001968 FtsX-like permease family; Region: FtsX; pfam02687 272558001969 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 272558001970 TM-ABC transporter signature motif; other site 272558001971 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 272558001972 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 272558001973 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272558001974 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272558001975 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272558001976 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272558001977 MoxR-like ATPases [General function prediction only]; Region: COG0714 272558001978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558001979 Walker A motif; other site 272558001980 ATP binding site [chemical binding]; other site 272558001981 Walker B motif; other site 272558001982 arginine finger; other site 272558001983 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272558001984 Protein of unknown function DUF58; Region: DUF58; pfam01882 272558001985 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558001986 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 272558001987 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272558001988 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272558001989 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 272558001990 GMP synthase; Reviewed; Region: guaA; PRK00074 272558001991 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272558001992 AMP/PPi binding site [chemical binding]; other site 272558001993 candidate oxyanion hole; other site 272558001994 catalytic triad [active] 272558001995 potential glutamine specificity residues [chemical binding]; other site 272558001996 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272558001997 ATP Binding subdomain [chemical binding]; other site 272558001998 Ligand Binding sites [chemical binding]; other site 272558001999 Dimerization subdomain; other site 272558002000 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272558002001 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 272558002002 Flavodoxin; Region: Flavodoxin_1; pfam00258 272558002003 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 272558002004 FAD binding pocket [chemical binding]; other site 272558002005 FAD binding motif [chemical binding]; other site 272558002006 catalytic residues [active] 272558002007 NAD binding pocket [chemical binding]; other site 272558002008 phosphate binding motif [ion binding]; other site 272558002009 beta-alpha-beta structure motif; other site 272558002010 sulfite reductase subunit beta; Provisional; Region: PRK13504 272558002011 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272558002012 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 272558002013 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272558002014 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272558002015 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272558002016 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272558002017 putative active site [active] 272558002018 putative NTP binding site [chemical binding]; other site 272558002019 putative nucleic acid binding site [nucleotide binding]; other site 272558002020 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272558002021 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 272558002022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558002023 putative substrate translocation pore; other site 272558002024 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 272558002025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558002026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558002027 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272558002028 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272558002029 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272558002030 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 272558002031 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 272558002032 [2Fe-2S] cluster binding site [ion binding]; other site 272558002033 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 272558002034 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 272558002035 [4Fe-4S] binding site [ion binding]; other site 272558002036 molybdopterin cofactor binding site; other site 272558002037 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 272558002038 molybdopterin cofactor binding site; other site 272558002039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 272558002040 MOSC domain; Region: MOSC; pfam03473 272558002041 3-alpha domain; Region: 3-alpha; pfam03475 272558002042 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 272558002043 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 272558002044 malonyl-CoA binding site [chemical binding]; other site 272558002045 dimer interface [polypeptide binding]; other site 272558002046 product binding site; other site 272558002047 active site 272558002048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 272558002049 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 272558002050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558002051 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558002052 DNA binding residues [nucleotide binding] 272558002053 hypothetical protein; Provisional; Region: PRK04164 272558002054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 272558002055 NETI protein; Region: NETI; pfam14044 272558002056 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272558002057 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 272558002058 ATP-grasp domain; Region: ATP-grasp; pfam02222 272558002059 adenylosuccinate lyase; Provisional; Region: PRK07492 272558002060 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272558002061 tetramer interface [polypeptide binding]; other site 272558002062 active site 272558002063 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272558002064 ATP binding site [chemical binding]; other site 272558002065 active site 272558002066 substrate binding site [chemical binding]; other site 272558002067 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 272558002068 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272558002069 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272558002070 putative active site [active] 272558002071 catalytic triad [active] 272558002072 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272558002073 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272558002074 dimerization interface [polypeptide binding]; other site 272558002075 ATP binding site [chemical binding]; other site 272558002076 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272558002077 dimerization interface [polypeptide binding]; other site 272558002078 ATP binding site [chemical binding]; other site 272558002079 amidophosphoribosyltransferase; Provisional; Region: PRK07631 272558002080 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272558002081 active site 272558002082 tetramer interface [polypeptide binding]; other site 272558002083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558002084 active site 272558002085 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272558002086 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272558002087 dimerization interface [polypeptide binding]; other site 272558002088 putative ATP binding site [chemical binding]; other site 272558002089 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272558002090 active site 272558002091 substrate binding site [chemical binding]; other site 272558002092 cosubstrate binding site; other site 272558002093 catalytic site [active] 272558002094 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272558002095 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272558002096 purine monophosphate binding site [chemical binding]; other site 272558002097 dimer interface [polypeptide binding]; other site 272558002098 putative catalytic residues [active] 272558002099 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272558002100 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272558002101 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272558002102 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272558002103 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272558002104 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 272558002105 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272558002106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558002107 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272558002108 active site 272558002109 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 272558002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 272558002111 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272558002112 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558002113 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272558002114 active site 272558002115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002116 dimerization interface [polypeptide binding]; other site 272558002117 putative DNA binding site [nucleotide binding]; other site 272558002118 putative Zn2+ binding site [ion binding]; other site 272558002119 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 272558002120 hypothetical protein; Provisional; Region: PRK09272 272558002121 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558002122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002123 putative DNA binding site [nucleotide binding]; other site 272558002124 putative Zn2+ binding site [ion binding]; other site 272558002125 MarR family; Region: MarR_2; cl17246 272558002126 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272558002127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558002128 Zn2+ binding site [ion binding]; other site 272558002129 Mg2+ binding site [ion binding]; other site 272558002130 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 272558002131 substrate binding site [chemical binding]; other site 272558002132 putative active site [active] 272558002133 dimer interface [polypeptide binding]; other site 272558002134 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272558002135 Part of AAA domain; Region: AAA_19; pfam13245 272558002136 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272558002137 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272558002138 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272558002139 nucleotide binding pocket [chemical binding]; other site 272558002140 K-X-D-G motif; other site 272558002141 catalytic site [active] 272558002142 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272558002143 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272558002144 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272558002145 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272558002146 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272558002147 Dimer interface [polypeptide binding]; other site 272558002148 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 272558002149 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 272558002150 putative dimer interface [polypeptide binding]; other site 272558002151 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 272558002152 putative dimer interface [polypeptide binding]; other site 272558002153 Predicted transcriptional regulators [Transcription]; Region: COG1725 272558002154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558002155 DNA-binding site [nucleotide binding]; DNA binding site 272558002156 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558002157 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558002158 Walker A/P-loop; other site 272558002159 ATP binding site [chemical binding]; other site 272558002160 Q-loop/lid; other site 272558002161 ABC transporter signature motif; other site 272558002162 Walker B; other site 272558002163 D-loop; other site 272558002164 H-loop/switch region; other site 272558002165 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 272558002166 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 272558002167 active site 272558002168 Mn binding site [ion binding]; other site 272558002169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002170 dimerization interface [polypeptide binding]; other site 272558002171 putative DNA binding site [nucleotide binding]; other site 272558002172 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558002173 putative Zn2+ binding site [ion binding]; other site 272558002174 Predicted transcriptional regulator [Transcription]; Region: COG1959 272558002175 Rrf2 family protein; Region: rrf2_super; TIGR00738 272558002176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558002177 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272558002178 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558002179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558002180 S-adenosylmethionine binding site [chemical binding]; other site 272558002181 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 272558002182 Na binding site [ion binding]; other site 272558002183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558002184 binding surface 272558002185 TPR motif; other site 272558002186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558002187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558002188 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 272558002189 putative Cl- selectivity filter; other site 272558002190 putative pore gating glutamate residue; other site 272558002191 Predicted membrane protein [Function unknown]; Region: COG2323 272558002192 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272558002193 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272558002194 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272558002195 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272558002196 GatB domain; Region: GatB_Yqey; smart00845 272558002197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558002198 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558002199 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558002200 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558002201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558002202 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 272558002203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272558002204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558002205 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 272558002206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558002207 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272558002208 DNA binding residues [nucleotide binding] 272558002209 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 272558002210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558002211 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558002212 active site turn [active] 272558002213 phosphorylation site [posttranslational modification] 272558002214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 272558002215 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272558002216 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272558002217 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 272558002218 putative lipid kinase; Reviewed; Region: PRK13337 272558002219 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272558002220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002221 putative DNA binding site [nucleotide binding]; other site 272558002222 dimerization interface [polypeptide binding]; other site 272558002223 putative Zn2+ binding site [ion binding]; other site 272558002224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 272558002225 YtkA-like; Region: YtkA; pfam13115 272558002226 YtkA-like; Region: YtkA; pfam13115 272558002227 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 272558002228 hydrophobic ligand binding site; other site 272558002229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 272558002230 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 272558002231 NAD(P) binding site [chemical binding]; other site 272558002232 catalytic residues [active] 272558002233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558002234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558002235 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558002236 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272558002237 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272558002238 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272558002239 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 272558002240 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 272558002241 Subtilase family; Region: Peptidase_S8; pfam00082 272558002242 active site 272558002243 catalytic residues [active] 272558002244 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272558002245 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272558002246 TRAM domain; Region: TRAM; cl01282 272558002247 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272558002248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272558002249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558002250 S-adenosylmethionine binding site [chemical binding]; other site 272558002251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272558002252 Transposase; Region: HTH_Tnp_1; cl17663 272558002253 putative transposase OrfB; Reviewed; Region: PHA02517 272558002254 HTH-like domain; Region: HTH_21; pfam13276 272558002255 Integrase core domain; Region: rve; pfam00665 272558002256 Integrase core domain; Region: rve_3; pfam13683 272558002257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558002258 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558002259 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 272558002260 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 272558002261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558002262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558002263 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272558002264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558002265 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558002266 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 272558002267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002268 dimerization interface [polypeptide binding]; other site 272558002269 putative DNA binding site [nucleotide binding]; other site 272558002270 putative Zn2+ binding site [ion binding]; other site 272558002271 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272558002272 hydrophobic ligand binding site; other site 272558002273 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 272558002274 Subtilase family; Region: Peptidase_S8; pfam00082 272558002275 active site 272558002276 catalytic residues [active] 272558002277 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 272558002278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558002279 Walker B; other site 272558002280 D-loop; other site 272558002281 H-loop/switch region; other site 272558002282 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 272558002283 active site pocket [active] 272558002284 oxyanion hole [active] 272558002285 catalytic triad [active] 272558002286 active site nucleophile [active] 272558002287 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 272558002288 Amb_all domain; Region: Amb_all; smart00656 272558002289 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558002290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558002291 Coenzyme A binding pocket [chemical binding]; other site 272558002292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002293 putative DNA binding site [nucleotide binding]; other site 272558002294 putative Zn2+ binding site [ion binding]; other site 272558002295 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272558002296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272558002297 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272558002298 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272558002299 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272558002300 DctM-like transporters; Region: DctM; pfam06808 272558002301 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272558002302 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272558002303 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272558002304 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 272558002305 putative active site [active] 272558002306 putative catalytic site [active] 272558002307 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 272558002308 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 272558002309 mannonate dehydratase; Provisional; Region: PRK03906 272558002310 D-mannonate oxidoreductase; Provisional; Region: PRK08277 272558002311 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 272558002312 putative NAD(P) binding site [chemical binding]; other site 272558002313 active site 272558002314 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558002315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558002316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 272558002317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558002318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558002319 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558002320 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272558002321 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272558002322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558002323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558002324 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272558002325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558002326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558002327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558002328 Walker A/P-loop; other site 272558002329 ATP binding site [chemical binding]; other site 272558002330 Q-loop/lid; other site 272558002331 ABC transporter signature motif; other site 272558002332 Walker B; other site 272558002333 D-loop; other site 272558002334 H-loop/switch region; other site 272558002335 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 272558002336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558002337 Walker A/P-loop; other site 272558002338 ATP binding site [chemical binding]; other site 272558002339 Q-loop/lid; other site 272558002340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558002341 ABC transporter signature motif; other site 272558002342 Walker B; other site 272558002343 D-loop; other site 272558002344 H-loop/switch region; other site 272558002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558002346 Walker A/P-loop; other site 272558002347 ATP binding site [chemical binding]; other site 272558002348 Q-loop/lid; other site 272558002349 ABC transporter signature motif; other site 272558002350 Walker B; other site 272558002351 D-loop; other site 272558002352 H-loop/switch region; other site 272558002353 Beta-lactamase; Region: Beta-lactamase; pfam00144 272558002354 Predicted transcriptional regulators [Transcription]; Region: COG1695 272558002355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558002356 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272558002357 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272558002358 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 272558002359 MMPL family; Region: MMPL; cl14618 272558002360 MMPL family; Region: MMPL; cl14618 272558002361 Predicted membrane protein [Function unknown]; Region: COG1511 272558002362 Bacterial PH domain; Region: bPH_4; pfam06713 272558002363 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272558002364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558002365 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558002366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558002367 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558002368 EamA-like transporter family; Region: EamA; pfam00892 272558002369 EamA-like transporter family; Region: EamA; pfam00892 272558002370 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272558002371 putative dimer interface [polypeptide binding]; other site 272558002372 catalytic triad [active] 272558002373 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 272558002374 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272558002375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272558002376 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 272558002377 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 272558002378 MoxR-like ATPases [General function prediction only]; Region: COG0714 272558002379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558002380 Walker A motif; other site 272558002381 ATP binding site [chemical binding]; other site 272558002382 Walker B motif; other site 272558002383 arginine finger; other site 272558002384 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272558002385 Protein of unknown function DUF58; Region: DUF58; pfam01882 272558002386 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 272558002387 Predicted membrane protein/domain [Function unknown]; Region: COG1714 272558002388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272558002389 catalytic core [active] 272558002390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002391 dimerization interface [polypeptide binding]; other site 272558002392 putative DNA binding site [nucleotide binding]; other site 272558002393 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558002394 putative Zn2+ binding site [ion binding]; other site 272558002395 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272558002396 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272558002397 putative NAD(P) binding site [chemical binding]; other site 272558002398 dimer interface [polypeptide binding]; other site 272558002399 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 272558002400 Putative D-pathway homolog; other site 272558002401 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272558002402 Low-spin heme binding site [chemical binding]; other site 272558002403 Subunit I/II interface [polypeptide binding]; other site 272558002404 Putative Q-pathway; other site 272558002405 Putative alternate electron transfer pathway; other site 272558002406 Putative water exit pathway; other site 272558002407 Binuclear center (active site) [active] 272558002408 Putative K-pathway homolog; other site 272558002409 Putative proton exit pathway; other site 272558002410 Subunit I/IIa interface [polypeptide binding]; other site 272558002411 Electron transfer pathway; other site 272558002412 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 272558002413 C-terminal cupredoxin domain of Ba3-like heme-copper oxidase subunit II; Region: ba3_CcO_II_C; cd13913 272558002414 Subunit I/II interface [polypeptide binding]; other site 272558002415 CuA binuclear site [ion binding]; other site 272558002416 Subunit II/IIa interface [polypeptide binding]; other site 272558002417 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272558002418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272558002419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272558002420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558002421 motif II; other site 272558002422 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 272558002423 Citrate transporter; Region: CitMHS; pfam03600 272558002424 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 272558002425 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 272558002426 active site 272558002427 putative substrate binding pocket [chemical binding]; other site 272558002428 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272558002429 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 272558002430 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272558002431 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 272558002432 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272558002433 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272558002434 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 272558002435 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272558002436 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272558002437 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 272558002438 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 272558002439 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272558002440 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 272558002441 Ligand binding site; other site 272558002442 metal-binding site 272558002443 FtsX-like permease family; Region: FtsX; pfam02687 272558002444 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272558002445 FtsX-like permease family; Region: FtsX; pfam02687 272558002446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558002447 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558002448 Walker A/P-loop; other site 272558002449 ATP binding site [chemical binding]; other site 272558002450 Q-loop/lid; other site 272558002451 ABC transporter signature motif; other site 272558002452 Walker B; other site 272558002453 D-loop; other site 272558002454 H-loop/switch region; other site 272558002455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558002456 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 272558002457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558002458 ATP binding site [chemical binding]; other site 272558002459 Mg2+ binding site [ion binding]; other site 272558002460 G-X-G motif; other site 272558002461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558002462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558002463 active site 272558002464 phosphorylation site [posttranslational modification] 272558002465 intermolecular recognition site; other site 272558002466 dimerization interface [polypeptide binding]; other site 272558002467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558002468 DNA binding site [nucleotide binding] 272558002469 Predicted membrane protein [Function unknown]; Region: COG2311 272558002470 Protein of unknown function (DUF418); Region: DUF418; pfam04235 272558002471 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 272558002472 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272558002473 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272558002474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 272558002475 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 272558002476 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272558002477 active site 272558002478 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 272558002479 active site 272558002480 homotetramer interface [polypeptide binding]; other site 272558002481 allantoate amidohydrolase; Reviewed; Region: PRK09290 272558002482 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272558002483 active site 272558002484 metal binding site [ion binding]; metal-binding site 272558002485 dimer interface [polypeptide binding]; other site 272558002486 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272558002487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558002488 catalytic residue [active] 272558002489 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558002490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272558002491 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 272558002492 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272558002493 dimer interface [polypeptide binding]; other site 272558002494 active site 272558002495 CoA binding pocket [chemical binding]; other site 272558002496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558002497 YlqD protein; Region: YlqD; pfam11068 272558002498 Trypanosomal VSG domain; Region: VSG_B; pfam13206 272558002499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558002500 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558002501 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558002502 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558002503 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 272558002504 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 272558002505 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 272558002506 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558002507 Glucitol operon activator [Transcription]; Region: GutM; COG4578 272558002508 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 272558002509 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 272558002510 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 272558002511 Nucleoside recognition; Region: Gate; pfam07670 272558002512 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 272558002513 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 272558002514 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 272558002515 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272558002516 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 272558002517 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272558002518 tetramer interface [polypeptide binding]; other site 272558002519 TPP-binding site [chemical binding]; other site 272558002520 heterodimer interface [polypeptide binding]; other site 272558002521 phosphorylation loop region [posttranslational modification] 272558002522 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272558002523 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272558002524 alpha subunit interface [polypeptide binding]; other site 272558002525 TPP binding site [chemical binding]; other site 272558002526 heterodimer interface [polypeptide binding]; other site 272558002527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558002528 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272558002529 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272558002530 E3 interaction surface; other site 272558002531 lipoyl attachment site [posttranslational modification]; other site 272558002532 e3 binding domain; Region: E3_binding; pfam02817 272558002533 e3 binding domain; Region: E3_binding; pfam02817 272558002534 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558002535 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 272558002536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558002537 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272558002538 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272558002539 Helix-turn-helix domain; Region: HTH_28; pfam13518 272558002540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558002541 sequence-specific DNA binding site [nucleotide binding]; other site 272558002542 salt bridge; other site 272558002543 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272558002544 CAT RNA binding domain; Region: CAT_RBD; cl03904 272558002545 PRD domain; Region: PRD; pfam00874 272558002546 PRD domain; Region: PRD; pfam00874 272558002547 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558002548 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558002549 inhibitor-cofactor binding pocket; inhibition site 272558002550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558002551 catalytic residue [active] 272558002552 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 272558002553 AAA domain; Region: AAA_26; pfam13500 272558002554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558002555 Histidine kinase; Region: HisKA_3; pfam07730 272558002556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558002557 ATP binding site [chemical binding]; other site 272558002558 Mg2+ binding site [ion binding]; other site 272558002559 G-X-G motif; other site 272558002560 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 272558002561 putative active site [active] 272558002562 FOG: PKD repeat [General function prediction only]; Region: COG3291 272558002563 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272558002564 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 272558002565 sugar binding site [chemical binding]; other site 272558002566 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272558002567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558002568 nucleotide binding site [chemical binding]; other site 272558002569 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558002570 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272558002571 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272558002572 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272558002573 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272558002574 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272558002575 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 272558002576 Uncharacterized conserved protein [Function unknown]; Region: COG3538 272558002577 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272558002578 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 272558002579 active site 272558002580 catalytic site [active] 272558002581 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272558002582 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 272558002583 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558002584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558002585 dimerization interface [polypeptide binding]; other site 272558002586 Histidine kinase; Region: His_kinase; pfam06580 272558002587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558002588 ATP binding site [chemical binding]; other site 272558002589 Mg2+ binding site [ion binding]; other site 272558002590 G-X-G motif; other site 272558002591 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272558002592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558002593 active site 272558002594 phosphorylation site [posttranslational modification] 272558002595 intermolecular recognition site; other site 272558002596 dimerization interface [polypeptide binding]; other site 272558002597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558002598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558002599 dimer interface [polypeptide binding]; other site 272558002600 conserved gate region; other site 272558002601 ABC-ATPase subunit interface; other site 272558002602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558002603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558002604 dimer interface [polypeptide binding]; other site 272558002605 conserved gate region; other site 272558002606 putative PBP binding loops; other site 272558002607 ABC-ATPase subunit interface; other site 272558002608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558002609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558002610 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 272558002611 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272558002612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558002613 nucleotide binding site [chemical binding]; other site 272558002614 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272558002615 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272558002616 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272558002617 homodimer interface [polypeptide binding]; other site 272558002618 substrate-cofactor binding pocket; other site 272558002619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558002620 catalytic residue [active] 272558002621 oxidoreductase; Provisional; Region: PRK06128 272558002622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558002623 NAD(P) binding site [chemical binding]; other site 272558002624 active site 272558002625 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272558002626 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272558002627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272558002628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272558002629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272558002630 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272558002631 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 272558002632 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272558002633 Uncharacterized conserved protein [Function unknown]; Region: COG3254 272558002634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558002635 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558002636 putative substrate translocation pore; other site 272558002637 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558002638 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558002639 active site 272558002640 metal binding site [ion binding]; metal-binding site 272558002641 Sporulation related domain; Region: SPOR; pfam05036 272558002642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272558002643 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558002644 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272558002645 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272558002646 dimer interface [polypeptide binding]; other site 272558002647 ADP-ribose binding site [chemical binding]; other site 272558002648 active site 272558002649 nudix motif; other site 272558002650 metal binding site [ion binding]; metal-binding site 272558002651 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558002652 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558002653 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272558002654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558002655 Walker A/P-loop; other site 272558002656 ATP binding site [chemical binding]; other site 272558002657 Q-loop/lid; other site 272558002658 ABC transporter signature motif; other site 272558002659 Walker B; other site 272558002660 D-loop; other site 272558002661 H-loop/switch region; other site 272558002662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558002663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558002664 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272558002665 Walker A/P-loop; other site 272558002666 ATP binding site [chemical binding]; other site 272558002667 Q-loop/lid; other site 272558002668 ABC transporter signature motif; other site 272558002669 Walker B; other site 272558002670 D-loop; other site 272558002671 H-loop/switch region; other site 272558002672 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 272558002673 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272558002674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558002675 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 272558002676 Walker A/P-loop; other site 272558002677 ATP binding site [chemical binding]; other site 272558002678 Q-loop/lid; other site 272558002679 ABC transporter signature motif; other site 272558002680 Walker B; other site 272558002681 D-loop; other site 272558002682 H-loop/switch region; other site 272558002683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558002684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558002685 dimer interface [polypeptide binding]; other site 272558002686 phosphorylation site [posttranslational modification] 272558002687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558002688 ATP binding site [chemical binding]; other site 272558002689 Mg2+ binding site [ion binding]; other site 272558002690 G-X-G motif; other site 272558002691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558002692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558002693 active site 272558002694 phosphorylation site [posttranslational modification] 272558002695 intermolecular recognition site; other site 272558002696 dimerization interface [polypeptide binding]; other site 272558002697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558002698 DNA binding site [nucleotide binding] 272558002699 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558002700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558002701 S-adenosylmethionine binding site [chemical binding]; other site 272558002702 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 272558002703 catalytic residue [active] 272558002704 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272558002705 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 272558002706 active site 272558002707 dimer interface [polypeptide binding]; other site 272558002708 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272558002709 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558002710 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272558002711 NAD(P) binding site [chemical binding]; other site 272558002712 DinB superfamily; Region: DinB_2; pfam12867 272558002713 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272558002714 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272558002715 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272558002716 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272558002717 putative substrate binding site [chemical binding]; other site 272558002718 putative ATP binding site [chemical binding]; other site 272558002719 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272558002720 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272558002721 active site 272558002722 phosphorylation site [posttranslational modification] 272558002723 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272558002724 active site 272558002725 P-loop; other site 272558002726 phosphorylation site [posttranslational modification] 272558002727 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272558002728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558002729 Predicted membrane protein [Function unknown]; Region: COG3859 272558002730 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 272558002731 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 272558002732 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 272558002733 catalytic triad [active] 272558002734 putative active site [active] 272558002735 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 272558002736 PA/protease domain interface [polypeptide binding]; other site 272558002737 putative integrin binding motif; other site 272558002738 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 272558002739 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 272558002740 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 272558002741 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272558002742 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272558002743 active site 272558002744 HIGH motif; other site 272558002745 KMSK motif region; other site 272558002746 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272558002747 tRNA binding surface [nucleotide binding]; other site 272558002748 anticodon binding site; other site 272558002749 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 272558002750 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 272558002751 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558002752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558002753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558002754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272558002755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272558002756 dimerization interface [polypeptide binding]; other site 272558002757 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272558002758 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272558002759 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 272558002760 rod-share determining protein MreBH; Provisional; Region: PRK13929 272558002761 MreB and similar proteins; Region: MreB_like; cd10225 272558002762 nucleotide binding site [chemical binding]; other site 272558002763 Mg binding site [ion binding]; other site 272558002764 putative protofilament interaction site [polypeptide binding]; other site 272558002765 RodZ interaction site [polypeptide binding]; other site 272558002766 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558002767 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272558002768 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558002769 active site turn [active] 272558002770 phosphorylation site [posttranslational modification] 272558002771 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272558002772 HPr interaction site; other site 272558002773 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272558002774 active site 272558002775 phosphorylation site [posttranslational modification] 272558002776 CAT RNA binding domain; Region: CAT_RBD; smart01061 272558002777 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272558002778 PRD domain; Region: PRD; pfam00874 272558002779 PRD domain; Region: PRD; pfam00874 272558002780 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272558002781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558002782 active site 272558002783 motif I; other site 272558002784 motif II; other site 272558002785 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558002786 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272558002787 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272558002788 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272558002789 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 272558002790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272558002791 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272558002792 active site 272558002793 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272558002794 dimer interface [polypeptide binding]; other site 272558002795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558002796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558002797 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 272558002798 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 272558002799 Subtilase family; Region: Peptidase_S8; pfam00082 272558002800 active site 272558002801 catalytic residues [active] 272558002802 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272558002803 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 272558002804 NodB motif; other site 272558002805 putative active site [active] 272558002806 putative catalytic site [active] 272558002807 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272558002808 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 272558002809 multidrug efflux protein; Reviewed; Region: PRK01766 272558002810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272558002811 cation binding site [ion binding]; other site 272558002812 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 272558002813 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 272558002814 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H_bacteria_like; cd13935 272558002815 active site 272558002816 RNA/DNA hybrid binding site [nucleotide binding]; other site 272558002817 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 272558002818 NAD(P) binding site [chemical binding]; other site 272558002819 catalytic residues [active] 272558002820 AbgT putative transporter family; Region: ABG_transport; pfam03806 272558002821 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272558002822 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558002823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558002824 putative DNA binding site [nucleotide binding]; other site 272558002825 putative Zn2+ binding site [ion binding]; other site 272558002826 AsnC family; Region: AsnC_trans_reg; pfam01037 272558002827 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272558002828 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272558002829 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 272558002830 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 272558002831 active site 272558002832 Zn binding site [ion binding]; other site 272558002833 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272558002834 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272558002835 Ca binding site [ion binding]; other site 272558002836 active site 272558002837 catalytic site [active] 272558002838 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 272558002839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558002840 DNA-binding site [nucleotide binding]; DNA binding site 272558002841 UTRA domain; Region: UTRA; pfam07702 272558002842 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 272558002843 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 272558002844 dimer interface [polypeptide binding]; other site 272558002845 active site 272558002846 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 272558002847 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 272558002848 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 272558002849 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272558002850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558002851 dimerization interface [polypeptide binding]; other site 272558002852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558002853 dimer interface [polypeptide binding]; other site 272558002854 putative CheW interface [polypeptide binding]; other site 272558002855 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 272558002856 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 272558002857 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272558002858 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272558002859 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558002860 TAP-like protein; Region: Abhydrolase_4; pfam08386 272558002861 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 272558002862 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272558002863 putative DNA binding site [nucleotide binding]; other site 272558002864 Helix-turn-helix domain; Region: HTH_20; pfam12840 272558002865 dimerization interface [polypeptide binding]; other site 272558002866 putative Zn2+ binding site [ion binding]; other site 272558002867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272558002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558002869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558002870 putative substrate translocation pore; other site 272558002871 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 272558002872 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272558002873 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 272558002874 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 272558002875 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272558002876 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272558002877 YfkD-like protein; Region: YfkD; pfam14167 272558002878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558002879 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272558002880 FeS/SAM binding site; other site 272558002881 YfkB-like domain; Region: YfkB; pfam08756 272558002882 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272558002883 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272558002884 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272558002885 catalytic core [active] 272558002886 Predicted membrane protein [Function unknown]; Region: COG3336 272558002887 Predicted membrane protein [Function unknown]; Region: COG4329 272558002888 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 272558002889 Fumarase C-terminus; Region: Fumerase_C; pfam05683 272558002890 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 272558002891 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 272558002892 NodB motif; other site 272558002893 active site 272558002894 catalytic site [active] 272558002895 Cd binding site [ion binding]; other site 272558002896 GAF domain; Region: GAF_2; pfam13185 272558002897 TRAM domain; Region: TRAM; pfam01938 272558002898 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 272558002899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558002900 S-adenosylmethionine binding site [chemical binding]; other site 272558002901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405 272558002902 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 272558002903 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272558002904 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 272558002905 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558002906 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558002907 DNA binding site [nucleotide binding] 272558002908 domain linker motif; other site 272558002909 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272558002910 dimerization interface [polypeptide binding]; other site 272558002911 ligand binding site [chemical binding]; other site 272558002912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558002913 dimer interface [polypeptide binding]; other site 272558002914 conserved gate region; other site 272558002915 putative PBP binding loops; other site 272558002916 ABC-ATPase subunit interface; other site 272558002917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558002918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558002919 dimer interface [polypeptide binding]; other site 272558002920 conserved gate region; other site 272558002921 putative PBP binding loops; other site 272558002922 ABC-ATPase subunit interface; other site 272558002923 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558002924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558002925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558002926 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 272558002927 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 272558002928 dimer interface [polypeptide binding]; other site 272558002929 active site 272558002930 heme binding site [chemical binding]; other site 272558002931 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 272558002932 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 272558002933 NAD+ binding site [chemical binding]; other site 272558002934 substrate binding site [chemical binding]; other site 272558002935 Zn binding site [ion binding]; other site 272558002936 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 272558002937 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272558002938 active site 272558002939 P-loop; other site 272558002940 phosphorylation site [posttranslational modification] 272558002941 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272558002942 methionine cluster; other site 272558002943 active site 272558002944 phosphorylation site [posttranslational modification] 272558002945 metal binding site [ion binding]; metal-binding site 272558002946 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272558002947 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272558002948 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272558002949 NAD binding site [chemical binding]; other site 272558002950 sugar binding site [chemical binding]; other site 272558002951 divalent metal binding site [ion binding]; other site 272558002952 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272558002953 dimer interface [polypeptide binding]; other site 272558002954 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 272558002955 putative active site [active] 272558002956 YdjC motif; other site 272558002957 Mg binding site [ion binding]; other site 272558002958 putative homodimer interface [polypeptide binding]; other site 272558002959 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272558002960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558002961 DNA-binding site [nucleotide binding]; DNA binding site 272558002962 UTRA domain; Region: UTRA; pfam07702 272558002963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558002964 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558002965 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 272558002966 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 272558002967 active site 272558002968 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272558002969 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272558002970 Interdomain contacts; other site 272558002971 Cytokine receptor motif; other site 272558002972 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272558002973 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272558002974 Ectoine synthase; Region: Ectoine_synth; pfam06339 272558002975 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558002976 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558002977 inhibitor-cofactor binding pocket; inhibition site 272558002978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558002979 catalytic residue [active] 272558002980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558002981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558002982 Coenzyme A binding pocket [chemical binding]; other site 272558002983 YfhE-like protein; Region: YfhE; pfam14152 272558002984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558002985 recombination regulator RecX; Provisional; Region: recX; PRK14135 272558002986 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 272558002987 YpzG-like protein; Region: YpzG; pfam14139 272558002988 Small acid-soluble spore protein K family; Region: SspK; pfam08176 272558002989 WVELL protein; Region: WVELL; pfam14043 272558002990 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 272558002991 Transmembrane secretion effector; Region: MFS_3; pfam05977 272558002992 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272558002993 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272558002994 minor groove reading motif; other site 272558002995 helix-hairpin-helix signature motif; other site 272558002996 substrate binding pocket [chemical binding]; other site 272558002997 active site 272558002998 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 272558002999 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272558003000 DNA binding and oxoG recognition site [nucleotide binding] 272558003001 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 272558003002 classical (c) SDRs; Region: SDR_c; cd05233 272558003003 NAD(P) binding site [chemical binding]; other site 272558003004 active site 272558003005 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 272558003006 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 272558003007 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272558003008 NAD(P) binding site [chemical binding]; other site 272558003009 aspartate aminotransferase; Provisional; Region: PRK07681 272558003010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558003011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003012 homodimer interface [polypeptide binding]; other site 272558003013 catalytic residue [active] 272558003014 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 272558003015 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 272558003016 putative NAD(P) binding site [chemical binding]; other site 272558003017 active site 272558003018 Small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; pfam04259 272558003019 hypothetical protein; Provisional; Region: PRK13662 272558003020 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558003021 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558003022 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272558003023 Walker A/P-loop; other site 272558003024 ATP binding site [chemical binding]; other site 272558003025 Q-loop/lid; other site 272558003026 ABC transporter signature motif; other site 272558003027 Walker B; other site 272558003028 D-loop; other site 272558003029 H-loop/switch region; other site 272558003030 Predicted membrane protein [Function unknown]; Region: COG4129 272558003031 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272558003032 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 272558003033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558003034 inhibitor-cofactor binding pocket; inhibition site 272558003035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003036 catalytic residue [active] 272558003037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558003038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558003039 non-specific DNA binding site [nucleotide binding]; other site 272558003040 salt bridge; other site 272558003041 sequence-specific DNA binding site [nucleotide binding]; other site 272558003042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558003043 putative DNA binding site [nucleotide binding]; other site 272558003044 dimerization interface [polypeptide binding]; other site 272558003045 putative Zn2+ binding site [ion binding]; other site 272558003046 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272558003047 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272558003048 catalytic triad [active] 272558003049 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 272558003050 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272558003051 NAD binding site [chemical binding]; other site 272558003052 ligand binding site [chemical binding]; other site 272558003053 catalytic site [active] 272558003054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 272558003055 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272558003056 metal binding site 2 [ion binding]; metal-binding site 272558003057 putative DNA binding helix; other site 272558003058 metal binding site 1 [ion binding]; metal-binding site 272558003059 dimer interface [polypeptide binding]; other site 272558003060 structural Zn2+ binding site [ion binding]; other site 272558003061 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 272558003062 Nucleotidyltransferase-like; Region: NTF-like; pfam14540 272558003063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558003064 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558003065 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558003066 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558003067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272558003068 DNA binding residues [nucleotide binding] 272558003069 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 272558003070 Phage protein; Region: DUF3647; pfam12363 272558003071 Phage-related protein [Function unknown]; Region: COG5412 272558003072 putative minor structural protein; Region: PHA01351 272558003073 membrane protein P6; Region: PHA01399 272558003074 Phage-related protein [Function unknown]; Region: COG4722 272558003075 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 272558003076 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 272558003077 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 272558003078 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558003079 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558003080 active site 272558003081 metal binding site [ion binding]; metal-binding site 272558003082 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558003083 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558003084 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558003085 holin, SPP1 family; Region: holin_SPP1; TIGR01592 272558003086 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 272558003087 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272558003088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558003089 ATP binding site [chemical binding]; other site 272558003090 putative Mg++ binding site [ion binding]; other site 272558003091 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272558003092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558003093 nucleotide binding region [chemical binding]; other site 272558003094 ATP-binding site [chemical binding]; other site 272558003095 Predicted membrane protein [Function unknown]; Region: COG1511 272558003096 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272558003097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272558003098 Uncharacterized small protein [Function unknown]; Region: COG5417 272558003099 Predicted membrane protein [Function unknown]; Region: COG4499 272558003100 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 272558003101 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 272558003102 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272558003103 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272558003104 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272558003105 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272558003106 AMP-binding enzyme C-terminal domain; Region: AMP-binding_C; cl17063 272558003107 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558003108 LXG domain of WXG superfamily; Region: LXG; pfam04740 272558003109 Protein of unknown function (DUF443); Region: DUF443; pfam04276 272558003110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 272558003111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558003112 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558003113 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558003114 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272558003115 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 272558003116 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272558003117 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272558003118 YtkA-like; Region: YtkA; pfam13115 272558003119 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 272558003120 nudix motif; other site 272558003121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558003122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558003123 WHG domain; Region: WHG; pfam13305 272558003124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003125 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558003126 Coenzyme A binding pocket [chemical binding]; other site 272558003127 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272558003128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558003129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558003130 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272558003131 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272558003132 intersubunit interface [polypeptide binding]; other site 272558003133 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558003134 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558003135 inhibitor-cofactor binding pocket; inhibition site 272558003136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003137 catalytic residue [active] 272558003138 PAS domain; Region: PAS_9; pfam13426 272558003139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558003140 putative active site [active] 272558003141 heme pocket [chemical binding]; other site 272558003142 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272558003143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558003144 Walker A motif; other site 272558003145 ATP binding site [chemical binding]; other site 272558003146 Walker B motif; other site 272558003147 arginine finger; other site 272558003148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558003149 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558003150 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558003151 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272558003152 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272558003153 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272558003154 tetramerization interface [polypeptide binding]; other site 272558003155 NAD(P) binding site [chemical binding]; other site 272558003156 catalytic residues [active] 272558003157 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 272558003158 putative GTP cyclohydrolase; Provisional; Region: PRK13674 272558003159 DinB superfamily; Region: DinB_2; pfam12867 272558003160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003161 Coenzyme A binding pocket [chemical binding]; other site 272558003162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558003163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558003164 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558003165 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558003166 Walker A/P-loop; other site 272558003167 ATP binding site [chemical binding]; other site 272558003168 Q-loop/lid; other site 272558003169 ABC transporter signature motif; other site 272558003170 Walker B; other site 272558003171 D-loop; other site 272558003172 H-loop/switch region; other site 272558003173 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272558003174 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 272558003175 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 272558003176 NAD(P) binding site [chemical binding]; other site 272558003177 catalytic residues [active] 272558003178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272558003179 dimer interface [polypeptide binding]; other site 272558003180 putative CheW interface [polypeptide binding]; other site 272558003181 heat shock protein 90; Provisional; Region: PRK05218 272558003182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558003183 ATP binding site [chemical binding]; other site 272558003184 Mg2+ binding site [ion binding]; other site 272558003185 G-X-G motif; other site 272558003186 Hsp90 protein; Region: HSP90; pfam00183 272558003187 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 272558003188 Predicted transcriptional regulators [Transcription]; Region: COG1733 272558003189 dimerization interface [polypeptide binding]; other site 272558003190 putative DNA binding site [nucleotide binding]; other site 272558003191 putative Zn2+ binding site [ion binding]; other site 272558003192 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272558003193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272558003194 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272558003195 active site 272558003196 catalytic tetrad [active] 272558003197 Predicted acetyltransferase [General function prediction only]; Region: COG3393 272558003198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003199 Coenzyme A binding pocket [chemical binding]; other site 272558003200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558003201 topology modulation protein; Reviewed; Region: PRK08118 272558003202 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272558003203 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272558003204 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272558003205 active site 272558003206 metal binding site [ion binding]; metal-binding site 272558003207 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272558003208 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272558003209 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 272558003210 generic binding surface I; other site 272558003211 generic binding surface II; other site 272558003212 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558003213 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 272558003214 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 272558003215 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 272558003216 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272558003217 Ferritin-like domain; Region: Ferritin; pfam00210 272558003218 dimerization interface [polypeptide binding]; other site 272558003219 DPS ferroxidase diiron center [ion binding]; other site 272558003220 ion pore; other site 272558003221 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 272558003222 epoxyqueuosine reductase; Region: TIGR00276 272558003223 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272558003224 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272558003225 HEAT-like repeat; Region: HEAT_EZ; pfam13513 272558003226 HEAT repeats; Region: HEAT_2; pfam13646 272558003227 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272558003228 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 272558003229 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272558003230 DNA binding site [nucleotide binding] 272558003231 active site 272558003232 Putative amidase domain; Region: Amidase_6; pfam12671 272558003233 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272558003234 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558003235 ABC-ATPase subunit interface; other site 272558003236 dimer interface [polypeptide binding]; other site 272558003237 putative PBP binding regions; other site 272558003238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558003239 ABC-ATPase subunit interface; other site 272558003240 dimer interface [polypeptide binding]; other site 272558003241 putative PBP binding regions; other site 272558003242 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 272558003243 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272558003244 Walker A/P-loop; other site 272558003245 ATP binding site [chemical binding]; other site 272558003246 Q-loop/lid; other site 272558003247 ABC transporter signature motif; other site 272558003248 Walker B; other site 272558003249 D-loop; other site 272558003250 H-loop/switch region; other site 272558003251 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 272558003252 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272558003253 putative ligand binding residues [chemical binding]; other site 272558003254 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 272558003255 PrkA AAA domain; Region: AAA_PrkA; smart00763 272558003256 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 272558003257 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272558003258 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272558003259 Catalytic site [active] 272558003260 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 272558003261 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 272558003262 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272558003263 metal ion-dependent adhesion site (MIDAS); other site 272558003264 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 272558003265 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272558003266 dinuclear metal binding motif [ion binding]; other site 272558003267 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558003268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558003269 inhibitor-cofactor binding pocket; inhibition site 272558003270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003271 catalytic residue [active] 272558003272 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 272558003273 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272558003274 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272558003275 siderophore binding site; other site 272558003276 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272558003277 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558003278 ABC-ATPase subunit interface; other site 272558003279 dimer interface [polypeptide binding]; other site 272558003280 putative PBP binding regions; other site 272558003281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558003282 ABC-ATPase subunit interface; other site 272558003283 dimer interface [polypeptide binding]; other site 272558003284 putative PBP binding regions; other site 272558003285 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558003286 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272558003287 Walker A/P-loop; other site 272558003288 ATP binding site [chemical binding]; other site 272558003289 Q-loop/lid; other site 272558003290 ABC transporter signature motif; other site 272558003291 Walker B; other site 272558003292 D-loop; other site 272558003293 H-loop/switch region; other site 272558003294 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 272558003295 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272558003296 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 272558003297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558003298 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 272558003299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003300 Coenzyme A binding pocket [chemical binding]; other site 272558003301 Predicted membrane protein [Function unknown]; Region: COG2311 272558003302 Protein of unknown function (DUF418); Region: DUF418; pfam04235 272558003303 Predicted membrane protein [Function unknown]; Region: COG2311 272558003304 Protein of unknown function (DUF418); Region: DUF418; cl12135 272558003305 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 272558003306 putative active site [active] 272558003307 catalytic triad [active] 272558003308 putative dimer interface [polypeptide binding]; other site 272558003309 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272558003310 dimer interface [polypeptide binding]; other site 272558003311 FMN binding site [chemical binding]; other site 272558003312 NADPH bind site [chemical binding]; other site 272558003313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558003314 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558003315 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558003316 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558003317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558003318 Histidine kinase; Region: HisKA_3; pfam07730 272558003319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558003320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558003321 active site 272558003322 phosphorylation site [posttranslational modification] 272558003323 intermolecular recognition site; other site 272558003324 dimerization interface [polypeptide binding]; other site 272558003325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558003326 DNA binding residues [nucleotide binding] 272558003327 dimerization interface [polypeptide binding]; other site 272558003328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 272558003329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558003330 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558003331 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558003332 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558003333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558003334 Walker A/P-loop; other site 272558003335 ATP binding site [chemical binding]; other site 272558003336 Q-loop/lid; other site 272558003337 ABC transporter signature motif; other site 272558003338 Walker B; other site 272558003339 D-loop; other site 272558003340 H-loop/switch region; other site 272558003341 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272558003342 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272558003343 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272558003344 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272558003345 Transcriptional regulator; Region: Rrf2; cl17282 272558003346 Rrf2 family protein; Region: rrf2_super; TIGR00738 272558003347 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 272558003348 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 272558003349 heme-binding site [chemical binding]; other site 272558003350 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 272558003351 FAD binding pocket [chemical binding]; other site 272558003352 FAD binding motif [chemical binding]; other site 272558003353 phosphate binding motif [ion binding]; other site 272558003354 beta-alpha-beta structure motif; other site 272558003355 NAD binding pocket [chemical binding]; other site 272558003356 Heme binding pocket [chemical binding]; other site 272558003357 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 272558003358 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 272558003359 metal binding site [ion binding]; metal-binding site 272558003360 dimer interface [polypeptide binding]; other site 272558003361 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 272558003362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558003363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003364 homodimer interface [polypeptide binding]; other site 272558003365 catalytic residue [active] 272558003366 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 272558003367 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 272558003368 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 272558003369 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 272558003370 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272558003371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558003372 DNA-binding site [nucleotide binding]; DNA binding site 272558003373 FCD domain; Region: FCD; pfam07729 272558003374 mannonate dehydratase; Provisional; Region: PRK03906 272558003375 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 272558003376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558003377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272558003378 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272558003379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003380 dimer interface [polypeptide binding]; other site 272558003381 conserved gate region; other site 272558003382 putative PBP binding loops; other site 272558003383 ABC-ATPase subunit interface; other site 272558003384 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558003385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003386 dimer interface [polypeptide binding]; other site 272558003387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272558003388 ABC-ATPase subunit interface; other site 272558003389 D-mannonate oxidoreductase; Provisional; Region: PRK08277 272558003390 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 272558003391 putative NAD(P) binding site [chemical binding]; other site 272558003392 active site 272558003393 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 272558003394 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272558003395 dimanganese center [ion binding]; other site 272558003396 tartrate dehydrogenase; Provisional; Region: PRK08194 272558003397 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272558003398 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272558003399 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272558003400 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272558003401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272558003402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003403 Coenzyme A binding pocket [chemical binding]; other site 272558003404 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 272558003405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558003406 active site 272558003407 motif I; other site 272558003408 motif II; other site 272558003409 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 272558003410 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 272558003411 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272558003412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558003413 Walker A/P-loop; other site 272558003414 ATP binding site [chemical binding]; other site 272558003415 Q-loop/lid; other site 272558003416 ABC transporter signature motif; other site 272558003417 Walker B; other site 272558003418 D-loop; other site 272558003419 H-loop/switch region; other site 272558003420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003421 dimer interface [polypeptide binding]; other site 272558003422 putative PBP binding loops; other site 272558003423 ABC-ATPase subunit interface; other site 272558003424 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558003425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003426 dimer interface [polypeptide binding]; other site 272558003427 conserved gate region; other site 272558003428 putative PBP binding loops; other site 272558003429 ABC-ATPase subunit interface; other site 272558003430 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558003431 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272558003432 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272558003433 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272558003434 active site 272558003435 catalytic site [active] 272558003436 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558003437 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272558003438 Walker A/P-loop; other site 272558003439 ATP binding site [chemical binding]; other site 272558003440 Q-loop/lid; other site 272558003441 ABC transporter signature motif; other site 272558003442 Walker B; other site 272558003443 D-loop; other site 272558003444 H-loop/switch region; other site 272558003445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558003446 ABC-ATPase subunit interface; other site 272558003447 dimer interface [polypeptide binding]; other site 272558003448 putative PBP binding regions; other site 272558003449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558003450 ABC-ATPase subunit interface; other site 272558003451 dimer interface [polypeptide binding]; other site 272558003452 putative PBP binding regions; other site 272558003453 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272558003454 homodimer interface [polypeptide binding]; other site 272558003455 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272558003456 active site pocket [active] 272558003457 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 272558003458 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272558003459 ADP-binding pocket [chemical binding]; other site 272558003460 homodimer interface [polypeptide binding]; other site 272558003461 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 272558003462 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272558003463 ligand binding site; other site 272558003464 oligomer interface; other site 272558003465 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272558003466 dimer interface [polypeptide binding]; other site 272558003467 N-terminal domain interface [polypeptide binding]; other site 272558003468 sulfate 1 binding site; other site 272558003469 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 272558003470 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272558003471 ligand binding site; other site 272558003472 oligomer interface; other site 272558003473 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272558003474 dimer interface [polypeptide binding]; other site 272558003475 N-terminal domain interface [polypeptide binding]; other site 272558003476 sulfate 1 binding site; other site 272558003477 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 272558003478 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 272558003479 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558003480 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272558003481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003482 Coenzyme A binding pocket [chemical binding]; other site 272558003483 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 272558003484 putative active site [active] 272558003485 catalytic triad [active] 272558003486 putative dimer interface [polypeptide binding]; other site 272558003487 YtkA-like; Region: YtkA; pfam13115 272558003488 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 272558003489 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272558003490 amphipathic channel; other site 272558003491 Asn-Pro-Ala signature motifs; other site 272558003492 glycerol kinase; Provisional; Region: glpK; PRK00047 272558003493 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272558003494 N- and C-terminal domain interface [polypeptide binding]; other site 272558003495 active site 272558003496 MgATP binding site [chemical binding]; other site 272558003497 catalytic site [active] 272558003498 metal binding site [ion binding]; metal-binding site 272558003499 glycerol binding site [chemical binding]; other site 272558003500 homotetramer interface [polypeptide binding]; other site 272558003501 homodimer interface [polypeptide binding]; other site 272558003502 FBP binding site [chemical binding]; other site 272558003503 protein IIAGlc interface [polypeptide binding]; other site 272558003504 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558003505 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272558003506 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272558003507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558003508 nucleotide binding site [chemical binding]; other site 272558003509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272558003510 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272558003511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558003512 Predicted acetyltransferase [General function prediction only]; Region: COG5628 272558003513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558003514 Coenzyme A binding pocket [chemical binding]; other site 272558003515 S-adenosylmethionine decarboxylase [Amino acid transport and metabolism]; Region: SpeD; COG1586 272558003516 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 272558003517 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558003518 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 272558003519 Spore germination protein; Region: Spore_permease; cl17796 272558003520 Spore germination protein; Region: Spore_permease; cl17796 272558003521 Spore germination protein; Region: Spore_permease; cl17796 272558003522 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272558003523 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272558003524 active site 272558003525 substrate binding site [chemical binding]; other site 272558003526 metal binding site [ion binding]; metal-binding site 272558003527 galactokinase; Provisional; Region: PRK05322 272558003528 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272558003529 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272558003530 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272558003531 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272558003532 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272558003533 NAD binding site [chemical binding]; other site 272558003534 homodimer interface [polypeptide binding]; other site 272558003535 active site 272558003536 substrate binding site [chemical binding]; other site 272558003537 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 272558003538 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 272558003539 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 272558003540 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 272558003541 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 272558003542 SpoVR like protein; Region: SpoVR; cl19504 272558003543 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272558003544 Interdomain contacts; other site 272558003545 Cytokine receptor motif; other site 272558003546 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 272558003547 metal binding site [ion binding]; metal-binding site 272558003548 active site 272558003549 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 272558003550 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 272558003551 active site 272558003552 catalytic triad [active] 272558003553 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 272558003554 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272558003555 Interdomain contacts; other site 272558003556 Cytokine receptor motif; other site 272558003557 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 272558003558 metal binding site [ion binding]; metal-binding site 272558003559 active site 272558003560 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558003561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558003562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558003563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003564 dimer interface [polypeptide binding]; other site 272558003565 conserved gate region; other site 272558003566 putative PBP binding loops; other site 272558003567 ABC-ATPase subunit interface; other site 272558003568 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558003569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003570 dimer interface [polypeptide binding]; other site 272558003571 conserved gate region; other site 272558003572 putative PBP binding loops; other site 272558003573 ABC-ATPase subunit interface; other site 272558003574 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 272558003575 active site 272558003576 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558003577 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558003578 HAMP domain; Region: HAMP; pfam00672 272558003579 Histidine kinase; Region: His_kinase; pfam06580 272558003580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558003581 ATP binding site [chemical binding]; other site 272558003582 Mg2+ binding site [ion binding]; other site 272558003583 G-X-G motif; other site 272558003584 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272558003585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558003586 active site 272558003587 phosphorylation site [posttranslational modification] 272558003588 intermolecular recognition site; other site 272558003589 dimerization interface [polypeptide binding]; other site 272558003590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558003591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558003592 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 272558003593 Ferritin-like domain; Region: Ferritin; pfam00210 272558003594 ferroxidase diiron center [ion binding]; other site 272558003595 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558003596 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558003597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558003598 Walker A/P-loop; other site 272558003599 ATP binding site [chemical binding]; other site 272558003600 Q-loop/lid; other site 272558003601 ABC transporter signature motif; other site 272558003602 Walker B; other site 272558003603 D-loop; other site 272558003604 H-loop/switch region; other site 272558003605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558003606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558003607 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272558003608 Walker A/P-loop; other site 272558003609 ATP binding site [chemical binding]; other site 272558003610 Q-loop/lid; other site 272558003611 ABC transporter signature motif; other site 272558003612 Walker B; other site 272558003613 D-loop; other site 272558003614 H-loop/switch region; other site 272558003615 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 272558003616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558003617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003618 homodimer interface [polypeptide binding]; other site 272558003619 catalytic residue [active] 272558003620 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 272558003621 Na2 binding site [ion binding]; other site 272558003622 putative substrate binding site 1 [chemical binding]; other site 272558003623 Na binding site 1 [ion binding]; other site 272558003624 putative substrate binding site 2 [chemical binding]; other site 272558003625 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 272558003626 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 272558003627 dimer interface [polypeptide binding]; other site 272558003628 active site 272558003629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272558003630 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 272558003631 FAD binding site [chemical binding]; other site 272558003632 homotetramer interface [polypeptide binding]; other site 272558003633 substrate binding pocket [chemical binding]; other site 272558003634 catalytic base [active] 272558003635 AMP-binding domain protein; Validated; Region: PRK08315 272558003636 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 272558003637 acyl-activating enzyme (AAE) consensus motif; other site 272558003638 putative AMP binding site [chemical binding]; other site 272558003639 putative active site [active] 272558003640 putative CoA binding site [chemical binding]; other site 272558003641 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 272558003642 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558003643 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558003644 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272558003645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272558003646 carboxyltransferase (CT) interaction site; other site 272558003647 biotinylation site [posttranslational modification]; other site 272558003648 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 272558003649 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 272558003650 active site 272558003651 catalytic residues [active] 272558003652 metal binding site [ion binding]; metal-binding site 272558003653 enoyl-CoA hydratase; Provisional; Region: PRK07657 272558003654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558003655 substrate binding site [chemical binding]; other site 272558003656 oxyanion hole (OAH) forming residues; other site 272558003657 trimer interface [polypeptide binding]; other site 272558003658 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272558003659 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272558003660 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272558003661 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272558003662 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 272558003663 acyl-activating enzyme (AAE) consensus motif; other site 272558003664 putative AMP binding site [chemical binding]; other site 272558003665 putative active site [active] 272558003666 putative CoA binding site [chemical binding]; other site 272558003667 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272558003668 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272558003669 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272558003670 Walker A/P-loop; other site 272558003671 ATP binding site [chemical binding]; other site 272558003672 Q-loop/lid; other site 272558003673 ABC transporter signature motif; other site 272558003674 Walker B; other site 272558003675 D-loop; other site 272558003676 H-loop/switch region; other site 272558003677 TOBE domain; Region: TOBE; pfam03459 272558003678 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272558003679 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272558003680 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 272558003681 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 272558003682 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 272558003683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 272558003684 Protein of unknown function (DUF445); Region: DUF445; pfam04286 272558003685 hypothetical protein; Provisional; Region: PRK13676 272558003686 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272558003687 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 272558003688 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272558003689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558003690 motif II; other site 272558003691 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558003692 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 272558003693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558003694 FeS/SAM binding site; other site 272558003695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558003696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558003697 active site 272558003698 phosphorylation site [posttranslational modification] 272558003699 intermolecular recognition site; other site 272558003700 dimerization interface [polypeptide binding]; other site 272558003701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558003702 DNA binding site [nucleotide binding] 272558003703 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272558003704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558003705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558003706 dimer interface [polypeptide binding]; other site 272558003707 phosphorylation site [posttranslational modification] 272558003708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558003709 ATP binding site [chemical binding]; other site 272558003710 Mg2+ binding site [ion binding]; other site 272558003711 G-X-G motif; other site 272558003712 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558003713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558003714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558003715 Walker A/P-loop; other site 272558003716 ATP binding site [chemical binding]; other site 272558003717 Q-loop/lid; other site 272558003718 ABC transporter signature motif; other site 272558003719 Walker B; other site 272558003720 D-loop; other site 272558003721 H-loop/switch region; other site 272558003722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558003723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558003724 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272558003725 Walker A/P-loop; other site 272558003726 ATP binding site [chemical binding]; other site 272558003727 Q-loop/lid; other site 272558003728 ABC transporter signature motif; other site 272558003729 Walker B; other site 272558003730 D-loop; other site 272558003731 H-loop/switch region; other site 272558003732 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 272558003733 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 272558003734 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 272558003735 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272558003736 active site 272558003737 dimerization interface [polypeptide binding]; other site 272558003738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558003739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558003740 putative substrate translocation pore; other site 272558003741 YhzD-like protein; Region: YhzD; pfam14120 272558003742 Predicted transcriptional regulators [Transcription]; Region: COG1725 272558003743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558003744 DNA-binding site [nucleotide binding]; DNA binding site 272558003745 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558003746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558003747 Walker A/P-loop; other site 272558003748 ATP binding site [chemical binding]; other site 272558003749 Q-loop/lid; other site 272558003750 ABC transporter signature motif; other site 272558003751 Walker B; other site 272558003752 D-loop; other site 272558003753 H-loop/switch region; other site 272558003754 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 272558003755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558003756 Walker A/P-loop; other site 272558003757 ATP binding site [chemical binding]; other site 272558003758 Q-loop/lid; other site 272558003759 ABC transporter signature motif; other site 272558003760 Walker B; other site 272558003761 D-loop; other site 272558003762 H-loop/switch region; other site 272558003763 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272558003764 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272558003765 Acyltransferase family; Region: Acyl_transf_3; cl19154 272558003766 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272558003767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558003768 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558003769 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558003770 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558003771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558003772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558003773 active site 272558003774 phosphorylation site [posttranslational modification] 272558003775 intermolecular recognition site; other site 272558003776 dimerization interface [polypeptide binding]; other site 272558003777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558003778 DNA binding site [nucleotide binding] 272558003779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558003780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558003781 dimer interface [polypeptide binding]; other site 272558003782 phosphorylation site [posttranslational modification] 272558003783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558003784 ATP binding site [chemical binding]; other site 272558003785 Mg2+ binding site [ion binding]; other site 272558003786 G-X-G motif; other site 272558003787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558003788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558003789 putative substrate translocation pore; other site 272558003790 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 272558003791 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272558003792 generic binding surface II; other site 272558003793 generic binding surface I; other site 272558003794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558003795 Zn2+ binding site [ion binding]; other site 272558003796 Mg2+ binding site [ion binding]; other site 272558003797 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 272558003798 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 272558003799 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 272558003800 SurA N-terminal domain; Region: SurA_N_3; cl07813 272558003801 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272558003802 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 272558003803 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 272558003804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 272558003805 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 272558003806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558003807 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558003808 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558003809 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558003810 transcriptional regulator Hpr; Provisional; Region: PRK13777 272558003811 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558003812 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272558003813 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 272558003814 homodimer interface [polypeptide binding]; other site 272558003815 substrate-cofactor binding pocket; other site 272558003816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558003817 catalytic residue [active] 272558003818 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272558003819 HIT family signature motif; other site 272558003820 catalytic residue [active] 272558003821 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 272558003822 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558003823 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272558003824 Walker A/P-loop; other site 272558003825 ATP binding site [chemical binding]; other site 272558003826 Q-loop/lid; other site 272558003827 ABC transporter signature motif; other site 272558003828 Walker B; other site 272558003829 D-loop; other site 272558003830 H-loop/switch region; other site 272558003831 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 272558003832 EcsC protein family; Region: EcsC; pfam12787 272558003833 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272558003834 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 272558003835 Holliday junction regulator protein family C-terminal repeat; Region: HJURP_C; pfam12347 272558003836 PspA/IM30 family; Region: PspA_IM30; pfam04012 272558003837 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272558003838 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272558003839 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 272558003840 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272558003841 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272558003842 Predicted membrane protein [Function unknown]; Region: COG4758 272558003843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558003844 HAMP domain; Region: HAMP; pfam00672 272558003845 Histidine kinase; Region: HisKA_3; pfam07730 272558003846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558003847 ATP binding site [chemical binding]; other site 272558003848 Mg2+ binding site [ion binding]; other site 272558003849 G-X-G motif; other site 272558003850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558003851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558003852 active site 272558003853 phosphorylation site [posttranslational modification] 272558003854 intermolecular recognition site; other site 272558003855 dimerization interface [polypeptide binding]; other site 272558003856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558003857 DNA binding residues [nucleotide binding] 272558003858 dimerization interface [polypeptide binding]; other site 272558003859 Transglycosylase; Region: Transgly; pfam00912 272558003860 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272558003861 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558003862 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272558003863 substrate binding site [chemical binding]; other site 272558003864 active site 272558003865 ferrochelatase; Provisional; Region: PRK12435 272558003866 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272558003867 C-terminal domain interface [polypeptide binding]; other site 272558003868 active site 272558003869 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272558003870 active site 272558003871 N-terminal domain interface [polypeptide binding]; other site 272558003872 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 272558003873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272558003874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558003875 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272558003876 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272558003877 FMN binding site [chemical binding]; other site 272558003878 substrate binding site [chemical binding]; other site 272558003879 putative catalytic residue [active] 272558003880 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 272558003881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558003882 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558003883 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558003884 NMT1-like family; Region: NMT1_2; pfam13379 272558003885 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272558003886 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272558003887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003888 dimer interface [polypeptide binding]; other site 272558003889 conserved gate region; other site 272558003890 putative PBP binding loops; other site 272558003891 ABC-ATPase subunit interface; other site 272558003892 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272558003893 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272558003894 Walker A/P-loop; other site 272558003895 ATP binding site [chemical binding]; other site 272558003896 Q-loop/lid; other site 272558003897 ABC transporter signature motif; other site 272558003898 Walker B; other site 272558003899 D-loop; other site 272558003900 H-loop/switch region; other site 272558003901 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 272558003902 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 272558003903 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272558003904 GTP1/OBG; Region: GTP1_OBG; pfam01018 272558003905 Obg GTPase; Region: Obg; cd01898 272558003906 G1 box; other site 272558003907 GTP/Mg2+ binding site [chemical binding]; other site 272558003908 Switch I region; other site 272558003909 G2 box; other site 272558003910 G3 box; other site 272558003911 Switch II region; other site 272558003912 G4 box; other site 272558003913 G5 box; other site 272558003914 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272558003915 hypothetical protein; Provisional; Region: PRK04435 272558003916 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 272558003917 prephenate dehydratase; Provisional; Region: PRK11898 272558003918 Prephenate dehydratase; Region: PDT; pfam00800 272558003919 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272558003920 putative L-Phe binding site [chemical binding]; other site 272558003921 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 272558003922 HTH domain; Region: HTH_11; pfam08279 272558003923 3H domain; Region: 3H; pfam02829 272558003924 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272558003925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558003926 catalytic residue [active] 272558003927 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 272558003928 L-aspartate oxidase; Provisional; Region: PRK06175 272558003929 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272558003930 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 272558003931 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272558003932 dimerization interface [polypeptide binding]; other site 272558003933 active site 272558003934 quinolinate synthetase; Provisional; Region: PRK09375 272558003935 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558003936 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272558003937 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 272558003938 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 272558003939 BofC C-terminal domain; Region: BofC_C; pfam08955 272558003940 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272558003941 RuvA N terminal domain; Region: RuvA_N; pfam01330 272558003942 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272558003943 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272558003944 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272558003945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558003946 Walker B motif; other site 272558003947 arginine finger; other site 272558003948 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272558003949 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 272558003950 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272558003951 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272558003952 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272558003953 Preprotein translocase subunit; Region: YajC; pfam02699 272558003954 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 272558003955 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 272558003956 transmembrane helices; other site 272558003957 Citrate transporter; Region: CitMHS; pfam03600 272558003958 Predicted membrane protein [Function unknown]; Region: COG2323 272558003959 stage V sporulation protein B; Region: spore_V_B; TIGR02900 272558003960 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272558003961 Predicted membrane protein [Function unknown]; Region: COG2426 272558003962 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 272558003963 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272558003964 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272558003965 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272558003966 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272558003967 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272558003968 Phage T7 capsid assembly protein; Region: Phage_T7_Capsid; cl14192 272558003969 Protein export membrane protein; Region: SecD_SecF; pfam02355 272558003970 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272558003971 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 272558003972 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272558003973 DHH family; Region: DHH; pfam01368 272558003974 DHHA1 domain; Region: DHHA1; pfam02272 272558003975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 272558003976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558003977 active site 272558003978 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272558003979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558003980 Zn2+ binding site [ion binding]; other site 272558003981 Mg2+ binding site [ion binding]; other site 272558003982 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272558003983 synthetase active site [active] 272558003984 NTP binding site [chemical binding]; other site 272558003985 metal binding site [ion binding]; metal-binding site 272558003986 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272558003987 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272558003988 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272558003989 putative active site [active] 272558003990 dimerization interface [polypeptide binding]; other site 272558003991 putative tRNAtyr binding site [nucleotide binding]; other site 272558003992 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558003993 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558003994 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272558003995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558003996 dimer interface [polypeptide binding]; other site 272558003997 conserved gate region; other site 272558003998 putative PBP binding loops; other site 272558003999 ABC-ATPase subunit interface; other site 272558004000 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558004001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558004002 dimer interface [polypeptide binding]; other site 272558004003 conserved gate region; other site 272558004004 putative PBP binding loops; other site 272558004005 ABC-ATPase subunit interface; other site 272558004006 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 272558004007 conserved cys residue [active] 272558004008 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558004009 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558004010 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558004011 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272558004012 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272558004013 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 272558004014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558004015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558004016 DNA binding site [nucleotide binding] 272558004017 domain linker motif; other site 272558004018 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 272558004019 putative dimerization interface [polypeptide binding]; other site 272558004020 putative ligand binding site [chemical binding]; other site 272558004021 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272558004022 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272558004023 dimer interface [polypeptide binding]; other site 272558004024 motif 1; other site 272558004025 active site 272558004026 motif 2; other site 272558004027 motif 3; other site 272558004028 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272558004029 anticodon binding site; other site 272558004030 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272558004031 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272558004032 dimer interface [polypeptide binding]; other site 272558004033 anticodon binding site; other site 272558004034 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272558004035 homodimer interface [polypeptide binding]; other site 272558004036 motif 1; other site 272558004037 active site 272558004038 motif 2; other site 272558004039 GAD domain; Region: GAD; pfam02938 272558004040 motif 3; other site 272558004041 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 272558004042 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272558004043 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272558004044 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 272558004045 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 272558004046 putative ATP binding site [chemical binding]; other site 272558004047 putative substrate interface [chemical binding]; other site 272558004048 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 272558004049 recombination factor protein RarA; Reviewed; Region: PRK13342 272558004050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558004051 Walker A motif; other site 272558004052 ATP binding site [chemical binding]; other site 272558004053 Walker B motif; other site 272558004054 arginine finger; other site 272558004055 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272558004056 Predicted membrane protein [Function unknown]; Region: COG2364 272558004057 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558004058 Predicted transcriptional regulator [Transcription]; Region: COG1959 272558004059 Rrf2 family protein; Region: rrf2_super; TIGR00738 272558004060 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272558004061 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558004062 catalytic residue [active] 272558004063 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272558004064 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272558004065 Ligand Binding Site [chemical binding]; other site 272558004066 TPR repeat; Region: TPR_11; pfam13414 272558004067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558004068 binding surface 272558004069 TPR motif; other site 272558004070 TPR repeat; Region: TPR_11; pfam13414 272558004071 TPR repeat; Region: TPR_11; pfam13414 272558004072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558004073 binding surface 272558004074 TPR motif; other site 272558004075 TPR repeat; Region: TPR_11; pfam13414 272558004076 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272558004077 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272558004078 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 272558004079 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 272558004080 PRC-barrel domain; Region: PRC; pfam05239 272558004081 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272558004082 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272558004083 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272558004084 motif 1; other site 272558004085 active site 272558004086 motif 2; other site 272558004087 motif 3; other site 272558004088 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272558004089 DHHA1 domain; Region: DHHA1; pfam02272 272558004090 hypothetical protein; Provisional; Region: PRK05473 272558004091 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 272558004092 hypothetical protein; Provisional; Region: PRK13678 272558004093 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272558004094 dimerization interface [polypeptide binding]; other site 272558004095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272558004096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558004097 S-adenosylmethionine binding site [chemical binding]; other site 272558004098 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272558004099 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272558004100 putative protease; Provisional; Region: PRK15452 272558004101 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272558004102 ATP-binding site [chemical binding]; other site 272558004103 Sugar specificity; other site 272558004104 Pyrimidine base specificity; other site 272558004105 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272558004106 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272558004107 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272558004108 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 272558004109 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 272558004110 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272558004111 YrhC-like protein; Region: YrhC; pfam14143 272558004112 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 272558004113 putative active site [active] 272558004114 putative CoA binding site [chemical binding]; other site 272558004115 nudix motif; other site 272558004116 metal binding site [ion binding]; metal-binding site 272558004117 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 272558004118 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 272558004119 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272558004120 sporulation sigma factor SigK; Reviewed; Region: PRK05803 272558004121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558004122 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558004123 DNA binding residues [nucleotide binding] 272558004124 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272558004125 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558004126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558004127 non-specific DNA binding site [nucleotide binding]; other site 272558004128 salt bridge; other site 272558004129 sequence-specific DNA binding site [nucleotide binding]; other site 272558004130 Predicted membrane protein [Function unknown]; Region: COG2323 272558004131 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 272558004132 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558004133 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558004134 active site 272558004135 metal binding site [ion binding]; metal-binding site 272558004136 Sporulation related domain; Region: SPOR; pfam05036 272558004137 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558004138 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558004139 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558004140 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558004141 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558004142 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558004143 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558004144 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558004145 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558004146 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558004147 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558004148 active site 272558004149 metal binding site [ion binding]; metal-binding site 272558004150 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 272558004151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558004152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004153 Coenzyme A binding pocket [chemical binding]; other site 272558004154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558004155 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558004156 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558004157 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272558004158 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 272558004159 NodB motif; other site 272558004160 putative active site [active] 272558004161 putative catalytic site [active] 272558004162 putative Zn binding site [ion binding]; other site 272558004163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 272558004164 Chitin binding domain; Region: Chitin_bind_3; pfam03067 272558004165 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272558004166 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272558004167 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272558004168 Sporulation inhibitor A; Region: Sda; pfam08970 272558004169 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272558004170 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 272558004171 tetramer interface [polypeptide binding]; other site 272558004172 heme binding pocket [chemical binding]; other site 272558004173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004174 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004175 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558004176 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558004177 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272558004178 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558004179 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558004180 histone-like DNA-binding protein HU; Region: HU; cd13831 272558004181 dimer interface [polypeptide binding]; other site 272558004182 DNA binding site [nucleotide binding] 272558004183 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272558004184 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272558004185 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 272558004186 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 272558004187 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 272558004188 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 272558004189 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 272558004190 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 272558004191 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272558004192 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 272558004193 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 272558004194 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 272558004195 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272558004196 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 272558004197 Sporulation inhibitor A; Region: Sda; pfam08970 272558004198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558004199 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272558004200 active site 272558004201 motif I; other site 272558004202 motif II; other site 272558004203 GTPase YqeH; Provisional; Region: PRK13796 272558004204 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272558004205 GTP/Mg2+ binding site [chemical binding]; other site 272558004206 G4 box; other site 272558004207 G5 box; other site 272558004208 G1 box; other site 272558004209 Switch I region; other site 272558004210 G2 box; other site 272558004211 G3 box; other site 272558004212 Switch II region; other site 272558004213 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272558004214 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272558004215 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272558004216 NAD(P) binding site [chemical binding]; other site 272558004217 shikimate binding site; other site 272558004218 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 272558004219 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272558004220 active site 272558004221 (T/H)XGH motif; other site 272558004222 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558004223 Zn2+ binding site [ion binding]; other site 272558004224 Mg2+ binding site [ion binding]; other site 272558004225 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272558004226 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272558004227 S1 domain; Region: S1_2; pfam13509 272558004228 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272558004229 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272558004230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558004231 S-adenosylmethionine binding site [chemical binding]; other site 272558004232 late competence protein ComER; Validated; Region: PRK07680 272558004233 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272558004234 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272558004235 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 272558004236 SLBB domain; Region: SLBB; pfam10531 272558004237 comEA protein; Region: comE; TIGR01259 272558004238 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272558004239 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272558004240 catalytic motif [active] 272558004241 Zn binding site [ion binding]; other site 272558004242 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272558004243 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272558004244 Competence protein; Region: Competence; pfam03772 272558004245 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272558004246 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272558004247 YqzM-like protein; Region: YqzM; pfam14141 272558004248 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272558004249 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272558004250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004251 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004252 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558004253 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558004254 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272558004255 germination protease; Provisional; Region: PRK02858 272558004256 GTP-binding protein LepA; Provisional; Region: PRK05433 272558004257 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272558004258 G1 box; other site 272558004259 putative GEF interaction site [polypeptide binding]; other site 272558004260 GTP/Mg2+ binding site [chemical binding]; other site 272558004261 Switch I region; other site 272558004262 G2 box; other site 272558004263 G3 box; other site 272558004264 Switch II region; other site 272558004265 G4 box; other site 272558004266 G5 box; other site 272558004267 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272558004268 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272558004269 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272558004270 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272558004271 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 272558004272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558004273 FeS/SAM binding site; other site 272558004274 HemN C-terminal domain; Region: HemN_C; pfam06969 272558004275 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272558004276 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272558004277 HrcA protein C terminal domain; Region: HrcA; pfam01628 272558004278 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272558004279 dimer interface [polypeptide binding]; other site 272558004280 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272558004281 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272558004282 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272558004283 nucleotide binding site [chemical binding]; other site 272558004284 NEF interaction site [polypeptide binding]; other site 272558004285 SBD interface [polypeptide binding]; other site 272558004286 SKIP/SNW domain; Region: SKIP_SNW; pfam02731 272558004287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004288 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004289 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558004290 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558004291 chaperone protein DnaJ; Provisional; Region: PRK14287 272558004292 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272558004293 HSP70 interaction site [polypeptide binding]; other site 272558004294 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272558004295 substrate binding site [polypeptide binding]; other site 272558004296 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272558004297 Zn binding sites [ion binding]; other site 272558004298 dimer interface [polypeptide binding]; other site 272558004299 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272558004300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558004301 S-adenosylmethionine binding site [chemical binding]; other site 272558004302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272558004303 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272558004304 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272558004305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558004306 FeS/SAM binding site; other site 272558004307 TRAM domain; Region: TRAM; cl01282 272558004308 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272558004309 intersubunit interface [polypeptide binding]; other site 272558004310 active site 272558004311 catalytic residue [active] 272558004312 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 272558004313 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272558004314 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272558004315 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272558004316 Yqey-like protein; Region: YqeY; pfam09424 272558004317 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 272558004318 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 272558004319 dimer interface [polypeptide binding]; other site 272558004320 active site residues [active] 272558004321 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 272558004322 hypothetical protein; Provisional; Region: PRK13665 272558004323 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 272558004324 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 272558004325 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 272558004326 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272558004327 PhoH-like protein; Region: PhoH; pfam02562 272558004328 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 272558004329 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 272558004330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558004331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558004332 Zn2+ binding site [ion binding]; other site 272558004333 Mg2+ binding site [ion binding]; other site 272558004334 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 272558004335 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 272558004336 trimer interface [polypeptide binding]; other site 272558004337 putative active site [active] 272558004338 Zn binding site [ion binding]; other site 272558004339 Uncharacterized conserved protein [Function unknown]; Region: COG2928 272558004340 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 272558004341 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272558004342 active site 272558004343 catalytic motif [active] 272558004344 Zn binding site [ion binding]; other site 272558004345 GTPase Era; Reviewed; Region: era; PRK00089 272558004346 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272558004347 G1 box; other site 272558004348 GTP/Mg2+ binding site [chemical binding]; other site 272558004349 Switch I region; other site 272558004350 G2 box; other site 272558004351 Switch II region; other site 272558004352 G3 box; other site 272558004353 G4 box; other site 272558004354 G5 box; other site 272558004355 KH domain; Region: KH_2; pfam07650 272558004356 YqzL-like protein; Region: YqzL; pfam14006 272558004357 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272558004358 Recombination protein O N terminal; Region: RecO_N; pfam11967 272558004359 Recombination protein O C terminal; Region: RecO_C; pfam02565 272558004360 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272558004361 dimer interface [polypeptide binding]; other site 272558004362 motif 1; other site 272558004363 active site 272558004364 motif 2; other site 272558004365 motif 3; other site 272558004366 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 272558004367 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272558004368 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272558004369 HTH domain; Region: HTH_11; pfam08279 272558004370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 272558004371 FOG: CBS domain [General function prediction only]; Region: COG0517 272558004372 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 272558004373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 272558004374 DNA primase; Validated; Region: dnaG; PRK05667 272558004375 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272558004376 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272558004377 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272558004378 active site 272558004379 metal binding site [ion binding]; metal-binding site 272558004380 interdomain interaction site; other site 272558004381 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272558004382 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272558004383 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272558004384 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272558004385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558004386 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272558004387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558004388 DNA binding residues [nucleotide binding] 272558004389 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272558004390 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272558004391 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 272558004392 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272558004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 272558004394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004395 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004396 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 272558004397 Fe-S cluster binding site [ion binding]; other site 272558004398 substrate binding site [chemical binding]; other site 272558004399 catalytic site [active] 272558004400 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 272558004401 YqfQ-like protein; Region: YqfQ; pfam14181 272558004402 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272558004403 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272558004404 ATP binding site [chemical binding]; other site 272558004405 Mg++ binding site [ion binding]; other site 272558004406 motif III; other site 272558004407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558004408 nucleotide binding region [chemical binding]; other site 272558004409 ATP-binding site [chemical binding]; other site 272558004410 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 272558004411 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272558004412 AP (apurinic/apyrimidinic) site pocket; other site 272558004413 DNA interaction; other site 272558004414 Metal-binding active site; metal-binding site 272558004415 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 272558004416 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272558004417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558004418 dimer interface [polypeptide binding]; other site 272558004419 phosphorylation site [posttranslational modification] 272558004420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558004421 ATP binding site [chemical binding]; other site 272558004422 Mg2+ binding site [ion binding]; other site 272558004423 G-X-G motif; other site 272558004424 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272558004425 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272558004426 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558004427 ABC-ATPase subunit interface; other site 272558004428 dimer interface [polypeptide binding]; other site 272558004429 putative PBP binding regions; other site 272558004430 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272558004431 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272558004432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272558004433 catalytic residue [active] 272558004434 polyphosphate kinase; Provisional; Region: PRK05443 272558004435 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272558004436 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272558004437 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272558004438 putative domain interface [polypeptide binding]; other site 272558004439 putative active site [active] 272558004440 catalytic site [active] 272558004441 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272558004442 putative domain interface [polypeptide binding]; other site 272558004443 putative active site [active] 272558004444 catalytic site [active] 272558004445 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272558004446 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272558004447 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558004448 nucleotide binding site [chemical binding]; other site 272558004449 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272558004450 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272558004451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558004452 ABC-ATPase subunit interface; other site 272558004453 dimer interface [polypeptide binding]; other site 272558004454 putative PBP binding regions; other site 272558004455 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272558004456 metal binding site 2 [ion binding]; metal-binding site 272558004457 putative DNA binding helix; other site 272558004458 metal binding site 1 [ion binding]; metal-binding site 272558004459 dimer interface [polypeptide binding]; other site 272558004460 structural Zn2+ binding site [ion binding]; other site 272558004461 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 272558004462 Uncharacterized conserved protein [Function unknown]; Region: COG5663 272558004463 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 272558004464 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272558004465 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 272558004466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558004467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558004468 putative substrate translocation pore; other site 272558004469 Predicted secreted protein [Function unknown]; Region: COG4086 272558004470 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 272558004471 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 272558004472 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 272558004473 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 272558004474 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272558004475 PhoU domain; Region: PhoU; pfam01895 272558004476 PhoU domain; Region: PhoU; pfam01895 272558004477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004478 Coenzyme A binding pocket [chemical binding]; other site 272558004479 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272558004480 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272558004481 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272558004482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558004483 putative substrate translocation pore; other site 272558004484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558004485 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272558004486 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272558004487 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558004488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004489 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004490 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558004491 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558004492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 272558004493 Uncharacterized conserved protein [Function unknown]; Region: COG1543 272558004494 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 272558004495 active site 272558004496 substrate binding site [chemical binding]; other site 272558004497 catalytic site [active] 272558004498 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 272558004499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558004500 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272558004501 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272558004502 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 272558004503 active site 272558004504 Substrate binding site; other site 272558004505 Mg++ binding site; other site 272558004506 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272558004507 Predicted membrane protein [Function unknown]; Region: COG1836 272558004508 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 272558004509 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272558004510 ATP binding site [chemical binding]; other site 272558004511 substrate interface [chemical binding]; other site 272558004512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558004513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558004514 TPR motif; other site 272558004515 binding surface 272558004516 TPR repeat; Region: TPR_11; pfam13414 272558004517 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558004518 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272558004519 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558004520 nucleotide binding site [chemical binding]; other site 272558004521 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 272558004522 Aspartase; Region: Aspartase; cd01357 272558004523 active sites [active] 272558004524 tetramer interface [polypeptide binding]; other site 272558004525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558004526 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 272558004527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558004528 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558004529 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272558004530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558004531 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272558004532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558004533 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272558004534 thiamine phosphate binding site [chemical binding]; other site 272558004535 active site 272558004536 pyrophosphate binding site [ion binding]; other site 272558004537 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272558004538 thiS-thiF/thiG interaction site; other site 272558004539 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272558004540 ThiS interaction site; other site 272558004541 putative active site [active] 272558004542 tetramer interface [polypeptide binding]; other site 272558004543 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272558004544 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272558004545 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272558004546 dimer interface [polypeptide binding]; other site 272558004547 substrate binding site [chemical binding]; other site 272558004548 ATP binding site [chemical binding]; other site 272558004549 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 272558004550 Uncharacterized conserved protein [Function unknown]; Region: COG0011 272558004551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004552 Coenzyme A binding pocket [chemical binding]; other site 272558004553 hypothetical protein; Provisional; Region: PRK13679 272558004554 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272558004555 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272558004556 Putative esterase; Region: Esterase; pfam00756 272558004557 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272558004558 tetramer interfaces [polypeptide binding]; other site 272558004559 binuclear metal-binding site [ion binding]; other site 272558004560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558004561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558004562 non-specific DNA binding site [nucleotide binding]; other site 272558004563 salt bridge; other site 272558004564 sequence-specific DNA binding site [nucleotide binding]; other site 272558004565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558004566 non-specific DNA binding site [nucleotide binding]; other site 272558004567 salt bridge; other site 272558004568 sequence-specific DNA binding site [nucleotide binding]; other site 272558004569 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272558004570 Class II fumarases; Region: Fumarase_classII; cd01362 272558004571 active site 272558004572 tetramer interface [polypeptide binding]; other site 272558004573 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 272558004574 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 272558004575 Nucleoside recognition; Region: Gate; pfam07670 272558004576 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 272558004577 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272558004578 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 272558004579 Sporulation inhibitor A; Region: Sda; pfam08970 272558004580 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 272558004581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272558004582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004583 Coenzyme A binding pocket [chemical binding]; other site 272558004584 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 272558004585 Spore germination protein; Region: Spore_permease; pfam03845 272558004586 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558004587 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 272558004588 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272558004589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272558004590 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272558004591 substrate binding pocket [chemical binding]; other site 272558004592 membrane-bound complex binding site; other site 272558004593 hinge residues; other site 272558004594 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272558004595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558004596 dimer interface [polypeptide binding]; other site 272558004597 conserved gate region; other site 272558004598 putative PBP binding loops; other site 272558004599 ABC-ATPase subunit interface; other site 272558004600 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272558004601 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272558004602 Walker A/P-loop; other site 272558004603 ATP binding site [chemical binding]; other site 272558004604 Q-loop/lid; other site 272558004605 ABC transporter signature motif; other site 272558004606 Walker B; other site 272558004607 D-loop; other site 272558004608 H-loop/switch region; other site 272558004609 Predicted membrane protein [Function unknown]; Region: COG4129 272558004610 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272558004611 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 272558004612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272558004613 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272558004614 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272558004615 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 272558004616 NADP binding site [chemical binding]; other site 272558004617 dimer interface [polypeptide binding]; other site 272558004618 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 272558004619 dimer interface [polypeptide binding]; other site 272558004620 substrate binding site [chemical binding]; other site 272558004621 metal binding site [ion binding]; metal-binding site 272558004622 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 272558004623 peptidase T-like protein; Region: PepT-like; TIGR01883 272558004624 metal binding site [ion binding]; metal-binding site 272558004625 putative dimer interface [polypeptide binding]; other site 272558004626 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272558004627 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272558004628 DNA polymerase IV; Validated; Region: PRK01810 272558004629 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272558004630 active site 272558004631 DNA binding site [nucleotide binding] 272558004632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004633 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004634 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558004635 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558004636 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272558004637 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272558004638 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 272558004639 flagellin; Reviewed; Region: PRK08869 272558004640 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272558004641 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272558004642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 272558004643 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272558004644 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 272558004645 putative hydrophobic ligand binding site [chemical binding]; other site 272558004646 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272558004647 active site 272558004648 FMN binding site [chemical binding]; other site 272558004649 substrate binding site [chemical binding]; other site 272558004650 homotetramer interface [polypeptide binding]; other site 272558004651 catalytic residue [active] 272558004652 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272558004653 FOG: CBS domain [General function prediction only]; Region: COG0517 272558004654 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272558004655 Uncharacterized small protein [Function unknown]; Region: COG5583 272558004656 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272558004657 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272558004658 Active Sites [active] 272558004659 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 272558004660 ATP-sulfurylase; Region: ATPS; cd00517 272558004661 active site 272558004662 HXXH motif; other site 272558004663 flexible loop; other site 272558004664 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272558004665 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272558004666 ligand-binding site [chemical binding]; other site 272558004667 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 272558004668 Subtilase family; Region: Peptidase_S8; pfam00082 272558004669 active site 272558004670 catalytic triad [active] 272558004671 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 272558004672 NodB motif; other site 272558004673 putative active site [active] 272558004674 putative catalytic site [active] 272558004675 Zn binding site [ion binding]; other site 272558004676 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272558004677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272558004678 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272558004679 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558004680 DNA binding residues [nucleotide binding] 272558004681 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 272558004682 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272558004683 active site 272558004684 SAM binding site [chemical binding]; other site 272558004685 homodimer interface [polypeptide binding]; other site 272558004686 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272558004687 active site 272558004688 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 272558004689 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 272558004690 putative active site [active] 272558004691 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 272558004692 putative active site [active] 272558004693 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 272558004694 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272558004695 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558004696 aspartate kinase; Reviewed; Region: PRK09034 272558004697 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 272558004698 putative catalytic residues [active] 272558004699 putative nucleotide binding site [chemical binding]; other site 272558004700 putative aspartate binding site [chemical binding]; other site 272558004701 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272558004702 allosteric regulatory residue; other site 272558004703 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272558004704 Ion transport protein; Region: Ion_trans; pfam00520 272558004705 WYL domain; Region: WYL; cl14852 272558004706 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272558004707 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 272558004708 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272558004709 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272558004710 putative catalytic cysteine [active] 272558004711 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 272558004712 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272558004713 nucleotide binding site [chemical binding]; other site 272558004714 homotetrameric interface [polypeptide binding]; other site 272558004715 putative phosphate binding site [ion binding]; other site 272558004716 putative allosteric binding site; other site 272558004717 PUA domain; Region: PUA; pfam01472 272558004718 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272558004719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558004720 NAD(P) binding site [chemical binding]; other site 272558004721 active site 272558004722 YqzH-like protein; Region: YqzH; pfam14164 272558004723 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272558004724 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272558004725 active site 272558004726 dimer interface [polypeptide binding]; other site 272558004727 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272558004728 Ligand Binding Site [chemical binding]; other site 272558004729 Molecular Tunnel; other site 272558004730 Rhomboid family; Region: Rhomboid; cl11446 272558004731 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 272558004732 heterodimer interface [polypeptide binding]; other site 272558004733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558004734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272558004735 dimer interface [polypeptide binding]; other site 272558004736 putative CheW interface [polypeptide binding]; other site 272558004737 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272558004738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558004739 NAD(P) binding site [chemical binding]; other site 272558004740 active site 272558004741 oxidoreductase; Provisional; Region: PRK06128 272558004742 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272558004743 NAD binding site [chemical binding]; other site 272558004744 metal binding site [ion binding]; metal-binding site 272558004745 active site 272558004746 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272558004747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558004748 active site 272558004749 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272558004750 HPr interaction site; other site 272558004751 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272558004752 active site 272558004753 phosphorylation site [posttranslational modification] 272558004754 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558004755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558004756 DNA binding site [nucleotide binding] 272558004757 domain linker motif; other site 272558004758 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272558004759 ligand binding site [chemical binding]; other site 272558004760 dimerization interface [polypeptide binding]; other site 272558004761 Predicted membrane protein [Function unknown]; Region: COG3689 272558004762 Predicted permease; Region: DUF318; pfam03773 272558004763 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272558004764 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272558004765 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272558004766 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272558004767 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272558004768 NAD(P) binding site [chemical binding]; other site 272558004769 putative active site [active] 272558004770 Bacitracin resistance protein BacA; Region: BacA; cl00858 272558004771 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272558004772 catalytic residues [active] 272558004773 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 272558004774 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272558004775 dimer interface [polypeptide binding]; other site 272558004776 ADP-ribose binding site [chemical binding]; other site 272558004777 active site 272558004778 nudix motif; other site 272558004779 metal binding site [ion binding]; metal-binding site 272558004780 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 272558004781 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272558004782 PHP-associated; Region: PHP_C; pfam13263 272558004783 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272558004784 stage II sporulation protein M; Region: spo_II_M; TIGR02831 272558004785 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272558004786 metal binding site 2 [ion binding]; metal-binding site 272558004787 putative DNA binding helix; other site 272558004788 metal binding site 1 [ion binding]; metal-binding site 272558004789 dimer interface [polypeptide binding]; other site 272558004790 structural Zn2+ binding site [ion binding]; other site 272558004791 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 272558004792 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272558004793 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272558004794 active site 272558004795 Int/Topo IB signature motif; other site 272558004796 phosphopentomutase; Provisional; Region: PRK05362 272558004797 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272558004798 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 272558004799 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272558004800 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 272558004801 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 272558004802 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272558004803 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272558004804 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272558004805 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 272558004806 putative hydrophobic ligand binding site [chemical binding]; other site 272558004807 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272558004808 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272558004809 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272558004810 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 272558004811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558004812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558004813 ATP binding site [chemical binding]; other site 272558004814 Mg2+ binding site [ion binding]; other site 272558004815 G-X-G motif; other site 272558004816 sporulation sigma factor SigF; Validated; Region: PRK05572 272558004817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558004818 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272558004819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558004820 DNA binding residues [nucleotide binding] 272558004821 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 272558004822 stage V sporulation protein AD; Validated; Region: PRK08304 272558004823 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 272558004824 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 272558004825 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 272558004826 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558004827 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272558004828 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272558004829 active site 272558004830 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272558004831 substrate binding site [chemical binding]; other site 272558004832 catalytic residues [active] 272558004833 dimer interface [polypeptide binding]; other site 272558004834 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272558004835 active site 272558004836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558004837 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558004838 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558004839 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558004840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558004841 dimer interface [polypeptide binding]; other site 272558004842 phosphorylation site [posttranslational modification] 272558004843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558004844 ATP binding site [chemical binding]; other site 272558004845 Mg2+ binding site [ion binding]; other site 272558004846 G-X-G motif; other site 272558004847 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 272558004848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558004849 active site 272558004850 phosphorylation site [posttranslational modification] 272558004851 intermolecular recognition site; other site 272558004852 dimerization interface [polypeptide binding]; other site 272558004853 Histidine kinase; Region: His_kinase; pfam06580 272558004854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558004855 ATP binding site [chemical binding]; other site 272558004856 Mg2+ binding site [ion binding]; other site 272558004857 G-X-G motif; other site 272558004858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558004859 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558004860 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558004861 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272558004862 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 272558004863 short chain dehydrogenase; Validated; Region: PRK08324 272558004864 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 272558004865 active site 272558004866 intersubunit interface [polypeptide binding]; other site 272558004867 Zn2+ binding site [ion binding]; other site 272558004868 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 272558004869 putative NAD(P) binding site [chemical binding]; other site 272558004870 active site 272558004871 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 272558004872 N- and C-terminal domain interface [polypeptide binding]; other site 272558004873 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 272558004874 active site 272558004875 putative catalytic site [active] 272558004876 metal binding site [ion binding]; metal-binding site 272558004877 ATP binding site [chemical binding]; other site 272558004878 carbohydrate binding site [chemical binding]; other site 272558004879 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 272558004880 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272558004881 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272558004882 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272558004883 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272558004884 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272558004885 catalytic motif [active] 272558004886 Zn binding site [ion binding]; other site 272558004887 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272558004888 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272558004889 Lumazine binding domain; Region: Lum_binding; pfam00677 272558004890 Lumazine binding domain; Region: Lum_binding; pfam00677 272558004891 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272558004892 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 272558004893 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272558004894 dimerization interface [polypeptide binding]; other site 272558004895 active site 272558004896 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272558004897 homopentamer interface [polypeptide binding]; other site 272558004898 active site 272558004899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004900 Coenzyme A binding pocket [chemical binding]; other site 272558004901 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 272558004902 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 272558004903 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 272558004904 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 272558004905 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 272558004906 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272558004907 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272558004908 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272558004909 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 272558004910 Sulfatase; Region: Sulfatase; cl19157 272558004911 Predicted membrane protein [Function unknown]; Region: COG2323 272558004912 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 272558004913 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 272558004914 stage V sporulation protein AD; Provisional; Region: PRK12404 272558004915 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 272558004916 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 272558004917 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 272558004918 Predicted membrane protein [Function unknown]; Region: COG2323 272558004919 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 272558004920 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272558004921 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272558004922 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 272558004923 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 272558004924 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 272558004925 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272558004926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558004927 RNA binding surface [nucleotide binding]; other site 272558004928 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272558004929 active site 272558004930 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272558004931 catalytic residues [active] 272558004932 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 272558004933 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 272558004934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558004935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558004936 active site 272558004937 phosphorylation site [posttranslational modification] 272558004938 intermolecular recognition site; other site 272558004939 dimerization interface [polypeptide binding]; other site 272558004940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558004941 DNA binding site [nucleotide binding] 272558004942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272558004943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558004944 dimerization interface [polypeptide binding]; other site 272558004945 PAS domain; Region: PAS; smart00091 272558004946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558004947 dimer interface [polypeptide binding]; other site 272558004948 phosphorylation site [posttranslational modification] 272558004949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558004950 ATP binding site [chemical binding]; other site 272558004951 Mg2+ binding site [ion binding]; other site 272558004952 G-X-G motif; other site 272558004953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004954 Coenzyme A binding pocket [chemical binding]; other site 272558004955 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558004956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558004957 Coenzyme A binding pocket [chemical binding]; other site 272558004958 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 272558004959 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272558004960 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 272558004961 putative binding site residues; other site 272558004962 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558004963 ABC-ATPase subunit interface; other site 272558004964 dimer interface [polypeptide binding]; other site 272558004965 putative PBP binding regions; other site 272558004966 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558004967 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272558004968 Walker A/P-loop; other site 272558004969 ATP binding site [chemical binding]; other site 272558004970 Q-loop/lid; other site 272558004971 ABC transporter signature motif; other site 272558004972 Walker B; other site 272558004973 D-loop; other site 272558004974 H-loop/switch region; other site 272558004975 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 272558004976 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 272558004977 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 272558004978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558004979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558004980 homodimer interface [polypeptide binding]; other site 272558004981 catalytic residue [active] 272558004982 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272558004983 homotrimer interface [polypeptide binding]; other site 272558004984 Walker A motif; other site 272558004985 GTP binding site [chemical binding]; other site 272558004986 Walker B motif; other site 272558004987 cobyric acid synthase; Provisional; Region: PRK00784 272558004988 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272558004989 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272558004990 catalytic triad [active] 272558004991 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 272558004992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272558004993 catalytic core [active] 272558004994 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]; Region: CobU; COG2087 272558004995 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 272558004996 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 272558004997 VanW like protein; Region: VanW; pfam04294 272558004998 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558004999 Spore germination protein; Region: Spore_permease; pfam03845 272558005000 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 272558005001 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272558005002 Peptidase family M23; Region: Peptidase_M23; pfam01551 272558005003 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558005004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558005005 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 272558005006 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 272558005007 ligand binding site [chemical binding]; other site 272558005008 NAD binding site [chemical binding]; other site 272558005009 dimerization interface [polypeptide binding]; other site 272558005010 catalytic site [active] 272558005011 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 272558005012 putative L-serine binding site [chemical binding]; other site 272558005013 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 272558005014 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558005015 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 272558005016 putative active site [active] 272558005017 Zn binding site [ion binding]; other site 272558005018 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272558005019 dimer interface [polypeptide binding]; other site 272558005020 substrate binding site [chemical binding]; other site 272558005021 metal binding sites [ion binding]; metal-binding site 272558005022 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272558005023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 272558005024 RQC domain; Region: RQC; cl09632 272558005025 Helix-turn-helix domain; Region: HTH_40; pfam14493 272558005026 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272558005027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558005028 ATP binding site [chemical binding]; other site 272558005029 putative Mg++ binding site [ion binding]; other site 272558005030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558005031 nucleotide binding region [chemical binding]; other site 272558005032 ATP-binding site [chemical binding]; other site 272558005033 CAAX protease self-immunity; Region: Abi; pfam02517 272558005034 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 272558005035 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272558005036 dimerization interface [polypeptide binding]; other site 272558005037 putative catalytic residue [active] 272558005038 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272558005039 amidohydrolase; Region: amidohydrolases; TIGR01891 272558005040 metal binding site [ion binding]; metal-binding site 272558005041 dimer interface [polypeptide binding]; other site 272558005042 DinB superfamily; Region: DinB_2; pfam12867 272558005043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558005044 Coenzyme A binding pocket [chemical binding]; other site 272558005045 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558005046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558005047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558005048 DNA binding residues [nucleotide binding] 272558005049 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 272558005050 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272558005051 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272558005052 putative active site [active] 272558005053 putative metal binding site [ion binding]; other site 272558005054 adaptor protein; Provisional; Region: PRK02899 272558005055 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 272558005056 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272558005057 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558005058 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272558005059 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558005060 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272558005061 NAD(P) binding site [chemical binding]; other site 272558005062 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 272558005063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272558005064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558005065 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 272558005066 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272558005067 active site 272558005068 homotetramer interface [polypeptide binding]; other site 272558005069 homodimer interface [polypeptide binding]; other site 272558005070 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 272558005071 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272558005072 homodimer interface [polypeptide binding]; other site 272558005073 substrate-cofactor binding pocket; other site 272558005074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005075 catalytic residue [active] 272558005076 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272558005077 homodimer interface [polypeptide binding]; other site 272558005078 substrate-cofactor binding pocket; other site 272558005079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005080 catalytic residue [active] 272558005081 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 272558005082 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272558005083 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272558005084 FAD binding site [chemical binding]; other site 272558005085 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272558005086 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 272558005087 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272558005088 substrate binding pocket [chemical binding]; other site 272558005089 dimer interface [polypeptide binding]; other site 272558005090 inhibitor binding site; inhibition site 272558005091 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272558005092 B12 binding site [chemical binding]; other site 272558005093 cobalt ligand [ion binding]; other site 272558005094 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272558005095 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 272558005096 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558005097 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272558005098 germination protein YpeB; Region: spore_YpeB; TIGR02889 272558005099 YpeB sporulation; Region: YPEB; pfam14620 272558005100 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 272558005101 Flagellar protein YcgR; Region: YcgR_2; pfam12945 272558005102 PilZ domain; Region: PilZ; pfam07238 272558005103 cytidylate kinase; Provisional; Region: cmk; PRK00023 272558005104 AAA domain; Region: AAA_17; cl19128 272558005105 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272558005106 CMP-binding site; other site 272558005107 The sites determining sugar specificity; other site 272558005108 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272558005109 putative acyl-acceptor binding pocket; other site 272558005110 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 272558005111 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272558005112 RNA binding site [nucleotide binding]; other site 272558005113 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272558005114 RNA binding site [nucleotide binding]; other site 272558005115 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272558005116 RNA binding site [nucleotide binding]; other site 272558005117 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272558005118 RNA binding site [nucleotide binding]; other site 272558005119 GTP-binding protein Der; Reviewed; Region: PRK00093 272558005120 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272558005121 G1 box; other site 272558005122 GTP/Mg2+ binding site [chemical binding]; other site 272558005123 Switch I region; other site 272558005124 G2 box; other site 272558005125 Switch II region; other site 272558005126 G3 box; other site 272558005127 G4 box; other site 272558005128 G5 box; other site 272558005129 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272558005130 G1 box; other site 272558005131 GTP/Mg2+ binding site [chemical binding]; other site 272558005132 Switch I region; other site 272558005133 G2 box; other site 272558005134 G3 box; other site 272558005135 Switch II region; other site 272558005136 G4 box; other site 272558005137 G5 box; other site 272558005138 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272558005139 membrane protein; Provisional; Region: PRK14405 272558005140 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272558005141 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272558005142 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272558005143 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 272558005144 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558005145 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 272558005146 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 272558005147 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 272558005148 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 272558005149 homodecamer interface [polypeptide binding]; other site 272558005150 active site 272558005151 putative catalytic site residues [active] 272558005152 zinc binding site [ion binding]; other site 272558005153 GTP-CH-I/GFRP interaction surface; other site 272558005154 transcription attenuation protein MtrB; Provisional; Region: PRK13251 272558005155 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 272558005156 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272558005157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558005158 S-adenosylmethionine binding site [chemical binding]; other site 272558005159 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 272558005160 putative active site [active] 272558005161 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 272558005162 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 272558005163 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272558005164 substrate binding pocket [chemical binding]; other site 272558005165 chain length determination region; other site 272558005166 substrate-Mg2+ binding site; other site 272558005167 catalytic residues [active] 272558005168 aspartate-rich region 1; other site 272558005169 active site lid residues [active] 272558005170 aspartate-rich region 2; other site 272558005171 Nucleoside diphosphate kinase; Region: NDK; pfam00334 272558005172 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272558005173 active site 272558005174 multimer interface [polypeptide binding]; other site 272558005175 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272558005176 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272558005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558005178 S-adenosylmethionine binding site [chemical binding]; other site 272558005179 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272558005180 Tetramer interface [polypeptide binding]; other site 272558005181 active site 272558005182 FMN-binding site [chemical binding]; other site 272558005183 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272558005184 active site 272558005185 dimer interface [polypeptide binding]; other site 272558005186 metal binding site [ion binding]; metal-binding site 272558005187 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 272558005188 homotrimer interaction site [polypeptide binding]; other site 272558005189 active site 272558005190 anthranilate synthase component I; Provisional; Region: PRK13569 272558005191 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272558005192 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272558005193 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272558005194 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272558005195 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272558005196 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272558005197 active site 272558005198 ribulose/triose binding site [chemical binding]; other site 272558005199 phosphate binding site [ion binding]; other site 272558005200 substrate (anthranilate) binding pocket [chemical binding]; other site 272558005201 product (indole) binding pocket [chemical binding]; other site 272558005202 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272558005203 active site 272558005204 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272558005205 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272558005206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005207 catalytic residue [active] 272558005208 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272558005209 substrate binding site [chemical binding]; other site 272558005210 active site 272558005211 catalytic residues [active] 272558005212 heterodimer interface [polypeptide binding]; other site 272558005213 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 272558005214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558005215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005216 homodimer interface [polypeptide binding]; other site 272558005217 catalytic residue [active] 272558005218 prephenate dehydrogenase; Validated; Region: PRK06545 272558005219 prephenate dehydrogenase; Validated; Region: PRK08507 272558005220 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 272558005221 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272558005222 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272558005223 hinge; other site 272558005224 active site 272558005225 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558005226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558005227 binding surface 272558005228 TPR motif; other site 272558005229 Tetratricopeptide repeat; Region: TPR_19; pfam14559 272558005230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558005231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558005232 binding surface 272558005233 TPR motif; other site 272558005234 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272558005235 hypothetical protein; Provisional; Region: PRK03636 272558005236 UPF0302 domain; Region: UPF0302; pfam08864 272558005237 IDEAL domain; Region: IDEAL; pfam08858 272558005238 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 272558005239 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 272558005240 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 272558005241 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 272558005242 iron-sulfur cluster [ion binding]; other site 272558005243 [2Fe-2S] cluster binding site [ion binding]; other site 272558005244 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 272558005245 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272558005246 interchain domain interface [polypeptide binding]; other site 272558005247 intrachain domain interface; other site 272558005248 heme bH binding site [chemical binding]; other site 272558005249 Qi binding site; other site 272558005250 heme bL binding site [chemical binding]; other site 272558005251 Qo binding site; other site 272558005252 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 272558005253 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 272558005254 intrachain domain interface; other site 272558005255 Qi binding site; other site 272558005256 interchain domain interface [polypeptide binding]; other site 272558005257 Qo binding site; other site 272558005258 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272558005259 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272558005260 Predicted membrane protein [Function unknown]; Region: COG4347 272558005261 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 272558005262 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 272558005263 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272558005264 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558005265 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558005266 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272558005267 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 272558005268 homodimer interface [polypeptide binding]; other site 272558005269 metal binding site [ion binding]; metal-binding site 272558005270 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272558005271 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272558005272 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272558005273 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 272558005274 active site 272558005275 dimer interfaces [polypeptide binding]; other site 272558005276 catalytic residues [active] 272558005277 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 272558005278 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 272558005279 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 272558005280 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 272558005281 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272558005282 active site 272558005283 NTP binding site [chemical binding]; other site 272558005284 metal binding triad [ion binding]; metal-binding site 272558005285 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272558005286 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272558005287 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272558005288 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272558005289 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272558005290 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272558005291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558005292 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558005293 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558005294 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558005295 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272558005296 oligomerization interface [polypeptide binding]; other site 272558005297 active site 272558005298 metal binding site [ion binding]; metal-binding site 272558005299 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272558005300 active site 272558005301 ATP-binding site [chemical binding]; other site 272558005302 pantoate-binding site; other site 272558005303 HXXH motif; other site 272558005304 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272558005305 tetramerization interface [polypeptide binding]; other site 272558005306 active site 272558005307 TPR repeat; Region: TPR_11; pfam13414 272558005308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558005309 binding surface 272558005310 TPR motif; other site 272558005311 TPR repeat; Region: TPR_11; pfam13414 272558005312 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 272558005313 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272558005314 active site 272558005315 catalytic site [active] 272558005316 substrate binding site [chemical binding]; other site 272558005317 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 272558005318 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272558005319 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 272558005320 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 272558005321 active site 272558005322 putative substrate binding pocket [chemical binding]; other site 272558005323 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 272558005324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 272558005325 aspartate aminotransferase; Provisional; Region: PRK05764 272558005326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558005327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005328 homodimer interface [polypeptide binding]; other site 272558005329 catalytic residue [active] 272558005330 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272558005331 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 272558005332 putative dimer interface [polypeptide binding]; other site 272558005333 putative anticodon binding site; other site 272558005334 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272558005335 homodimer interface [polypeptide binding]; other site 272558005336 motif 1; other site 272558005337 motif 2; other site 272558005338 active site 272558005339 motif 3; other site 272558005340 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272558005341 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272558005342 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272558005343 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272558005344 minor groove reading motif; other site 272558005345 helix-hairpin-helix signature motif; other site 272558005346 substrate binding pocket [chemical binding]; other site 272558005347 active site 272558005348 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272558005349 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 272558005350 G1 box; other site 272558005351 GTP/Mg2+ binding site [chemical binding]; other site 272558005352 G2 box; other site 272558005353 Switch I region; other site 272558005354 G3 box; other site 272558005355 Switch II region; other site 272558005356 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 272558005357 G4 box; other site 272558005358 G5 box; other site 272558005359 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 272558005360 G1 box; other site 272558005361 GTP/Mg2+ binding site [chemical binding]; other site 272558005362 G2 box; other site 272558005363 Switch I region; other site 272558005364 G3 box; other site 272558005365 Switch II region; other site 272558005366 G4 box; other site 272558005367 G5 box; other site 272558005368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558005369 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558005370 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558005371 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558005372 Transglycosylase; Region: Transgly; pfam00912 272558005373 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272558005374 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558005375 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272558005376 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 272558005377 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 272558005378 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 272558005379 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 272558005380 DNA binding residues [nucleotide binding] 272558005381 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 272558005382 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272558005383 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272558005384 active site residue [active] 272558005385 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272558005386 active site residue [active] 272558005387 Predicted membrane protein [Function unknown]; Region: COG2860 272558005388 UPF0126 domain; Region: UPF0126; pfam03458 272558005389 UPF0126 domain; Region: UPF0126; pfam03458 272558005390 threonine dehydratase; Validated; Region: PRK08639 272558005391 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272558005392 tetramer interface [polypeptide binding]; other site 272558005393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005394 catalytic residue [active] 272558005395 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 272558005396 putative Ile/Val binding site [chemical binding]; other site 272558005397 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272558005398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558005399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558005400 active site 272558005401 phosphorylation site [posttranslational modification] 272558005402 intermolecular recognition site; other site 272558005403 dimerization interface [polypeptide binding]; other site 272558005404 ribonuclease Z; Region: RNase_Z; TIGR02651 272558005405 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 272558005406 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272558005407 catalytic residues [active] 272558005408 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 272558005409 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272558005410 catalytic residues [active] 272558005411 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 272558005412 Virulence factor; Region: Virulence_fact; pfam13769 272558005413 HEAT repeats; Region: HEAT_2; pfam13646 272558005414 HEAT repeats; Region: HEAT_2; pfam13646 272558005415 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 272558005416 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 272558005417 Uncharacterized conserved protein [Function unknown]; Region: COG3402 272558005418 Predicted membrane protein [Function unknown]; Region: COG3428 272558005419 Bacterial PH domain; Region: bPH_2; pfam03703 272558005420 Bacterial PH domain; Region: bPH_2; pfam03703 272558005421 Bacterial PH domain; Region: bPH_2; pfam03703 272558005422 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 272558005423 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272558005424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272558005425 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 272558005426 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272558005427 Uncharacterized conserved protein [Function unknown]; Region: COG3332 272558005428 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272558005429 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272558005430 active site 272558005431 dimer interface [polypeptide binding]; other site 272558005432 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272558005433 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272558005434 active site 272558005435 FMN binding site [chemical binding]; other site 272558005436 substrate binding site [chemical binding]; other site 272558005437 3Fe-4S cluster binding site [ion binding]; other site 272558005438 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272558005439 domain interface; other site 272558005440 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272558005441 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272558005442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558005443 YpjP-like protein; Region: YpjP; pfam14005 272558005444 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 272558005445 Kinase associated protein B; Region: KapB; pfam08810 272558005446 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 272558005447 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272558005448 GAF domain; Region: GAF_3; pfam13492 272558005449 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272558005450 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272558005451 homodimer interface [polypeptide binding]; other site 272558005452 substrate-cofactor binding pocket; other site 272558005453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558005454 catalytic residue [active] 272558005455 homoserine dehydrogenase; Provisional; Region: PRK06270 272558005456 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272558005457 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272558005458 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 272558005459 NAD(P) binding site [chemical binding]; other site 272558005460 catalytic residues [active] 272558005461 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 272558005462 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272558005463 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272558005464 active site 272558005465 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558005466 EamA-like transporter family; Region: EamA; pfam00892 272558005467 EamA-like transporter family; Region: EamA; pfam00892 272558005468 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272558005469 dimer interface [polypeptide binding]; other site 272558005470 active site 272558005471 catalytic residue [active] 272558005472 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 272558005473 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272558005474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558005475 active site 272558005476 motif I; other site 272558005477 motif II; other site 272558005478 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558005479 biotin synthase; Validated; Region: PRK06256 272558005480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558005481 FeS/SAM binding site; other site 272558005482 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 272558005483 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 272558005484 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272558005485 minor groove reading motif; other site 272558005486 helix-hairpin-helix signature motif; other site 272558005487 substrate binding pocket [chemical binding]; other site 272558005488 active site 272558005489 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272558005490 AbgT putative transporter family; Region: ABG_transport; pfam03806 272558005491 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272558005492 FtsX-like permease family; Region: FtsX; pfam02687 272558005493 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558005494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558005495 Walker A/P-loop; other site 272558005496 ATP binding site [chemical binding]; other site 272558005497 Q-loop/lid; other site 272558005498 ABC transporter signature motif; other site 272558005499 Walker B; other site 272558005500 D-loop; other site 272558005501 H-loop/switch region; other site 272558005502 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272558005503 Predicted membrane protein [Function unknown]; Region: COG2323 272558005504 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 272558005505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558005506 catalytic residue [active] 272558005507 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 272558005508 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272558005509 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272558005510 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 272558005511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558005512 ATP binding site [chemical binding]; other site 272558005513 putative Mg++ binding site [ion binding]; other site 272558005514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558005515 nucleotide binding region [chemical binding]; other site 272558005516 ATP-binding site [chemical binding]; other site 272558005517 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 272558005518 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 272558005519 RNase_H superfamily; Region: RNase_H_2; pfam13482 272558005520 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 272558005521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4474 272558005522 cell division protein GpsB; Provisional; Region: PRK14127 272558005523 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272558005524 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 272558005525 RNA/DNA hybrid binding site [nucleotide binding]; other site 272558005526 active site 272558005527 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272558005528 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272558005529 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 272558005530 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272558005531 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272558005532 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272558005533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558005534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558005535 putative substrate translocation pore; other site 272558005536 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272558005537 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272558005538 active site 272558005539 catalytic site [active] 272558005540 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272558005541 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272558005542 phosphopeptide binding site; other site 272558005543 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 272558005544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558005545 DNA binding site [nucleotide binding] 272558005546 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 272558005547 active site 272558005548 metal binding site [ion binding]; metal-binding site 272558005549 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 272558005550 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 272558005551 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 272558005552 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 272558005553 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 272558005554 dimer interface [polypeptide binding]; other site 272558005555 putative tRNA-binding site [nucleotide binding]; other site 272558005556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558005557 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558005558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558005559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558005560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272558005561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272558005562 dimerization interface [polypeptide binding]; other site 272558005563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558005564 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558005565 putative substrate translocation pore; other site 272558005566 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 272558005567 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 272558005568 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272558005569 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272558005570 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 272558005571 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 272558005572 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272558005573 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 272558005574 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272558005575 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 272558005576 Carbon starvation protein CstA; Region: CstA; pfam02554 272558005577 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272558005578 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 272558005579 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272558005580 P loop; other site 272558005581 Nucleotide binding site [chemical binding]; other site 272558005582 DTAP/Switch II; other site 272558005583 Switch I; other site 272558005584 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558005585 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 272558005586 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272558005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558005588 dimer interface [polypeptide binding]; other site 272558005589 conserved gate region; other site 272558005590 putative PBP binding loops; other site 272558005591 ABC-ATPase subunit interface; other site 272558005592 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 272558005593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558005594 dimer interface [polypeptide binding]; other site 272558005595 conserved gate region; other site 272558005596 putative PBP binding loops; other site 272558005597 ABC-ATPase subunit interface; other site 272558005598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558005599 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 272558005600 Walker A/P-loop; other site 272558005601 ATP binding site [chemical binding]; other site 272558005602 Q-loop/lid; other site 272558005603 ABC transporter signature motif; other site 272558005604 Walker B; other site 272558005605 D-loop; other site 272558005606 H-loop/switch region; other site 272558005607 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272558005608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558005609 Walker A/P-loop; other site 272558005610 ATP binding site [chemical binding]; other site 272558005611 Q-loop/lid; other site 272558005612 ABC transporter signature motif; other site 272558005613 Walker B; other site 272558005614 D-loop; other site 272558005615 H-loop/switch region; other site 272558005616 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 272558005617 putative ligand binding site [chemical binding]; other site 272558005618 Protein of unknown function (DUF3723); Region: DUF3723; pfam12520 272558005619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272558005620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558005621 dimerization interface [polypeptide binding]; other site 272558005622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558005623 dimer interface [polypeptide binding]; other site 272558005624 phosphorylation site [posttranslational modification] 272558005625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558005626 ATP binding site [chemical binding]; other site 272558005627 Mg2+ binding site [ion binding]; other site 272558005628 G-X-G motif; other site 272558005629 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272558005630 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558005631 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272558005632 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272558005633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558005634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558005635 S-adenosylmethionine binding site [chemical binding]; other site 272558005636 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 272558005637 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 272558005638 ATP phosphoribosyltransferase; Region: HisG; cl15266 272558005639 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 272558005640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558005641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558005642 active site 272558005643 phosphorylation site [posttranslational modification] 272558005644 intermolecular recognition site; other site 272558005645 dimerization interface [polypeptide binding]; other site 272558005646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558005647 DNA binding site [nucleotide binding] 272558005648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558005649 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 272558005650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558005651 dimer interface [polypeptide binding]; other site 272558005652 phosphorylation site [posttranslational modification] 272558005653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558005654 ATP binding site [chemical binding]; other site 272558005655 Mg2+ binding site [ion binding]; other site 272558005656 G-X-G motif; other site 272558005657 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 272558005658 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272558005659 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272558005660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558005661 Zn2+ binding site [ion binding]; other site 272558005662 Mg2+ binding site [ion binding]; other site 272558005663 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 272558005664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558005665 Coenzyme A binding pocket [chemical binding]; other site 272558005666 Sterol carrier protein domain; Region: SCP2_2; pfam13530 272558005667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558005668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558005669 non-specific DNA binding site [nucleotide binding]; other site 272558005670 salt bridge; other site 272558005671 sequence-specific DNA binding site [nucleotide binding]; other site 272558005672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558005673 binding surface 272558005674 TPR motif; other site 272558005675 Predicted transcriptional regulator [Transcription]; Region: COG2378 272558005676 WYL domain; Region: WYL; pfam13280 272558005677 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 272558005678 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 272558005679 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272558005680 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272558005681 Bacterial transcriptional regulator; Region: IclR; pfam01614 272558005682 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 272558005683 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272558005684 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 272558005685 putative active site [active] 272558005686 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272558005687 tetramer interface [polypeptide binding]; other site 272558005688 TPP-binding site [chemical binding]; other site 272558005689 heterodimer interface [polypeptide binding]; other site 272558005690 phosphorylation loop region [posttranslational modification] 272558005691 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272558005692 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272558005693 alpha subunit interface [polypeptide binding]; other site 272558005694 TPP binding site [chemical binding]; other site 272558005695 heterodimer interface [polypeptide binding]; other site 272558005696 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558005697 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272558005698 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272558005699 E3 interaction surface; other site 272558005700 lipoyl attachment site [posttranslational modification]; other site 272558005701 e3 binding domain; Region: E3_binding; pfam02817 272558005702 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558005703 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 272558005704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558005705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558005706 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272558005707 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272558005708 GAF domain; Region: GAF; pfam01590 272558005709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558005710 Walker A motif; other site 272558005711 ATP binding site [chemical binding]; other site 272558005712 Walker B motif; other site 272558005713 arginine finger; other site 272558005714 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558005715 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272558005716 Cache domain; Region: Cache_1; pfam02743 272558005717 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272558005718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558005719 dimerization interface [polypeptide binding]; other site 272558005720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272558005721 dimer interface [polypeptide binding]; other site 272558005722 putative CheW interface [polypeptide binding]; other site 272558005723 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558005724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558005725 S-adenosylmethionine binding site [chemical binding]; other site 272558005726 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272558005727 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272558005728 NAD binding site [chemical binding]; other site 272558005729 catalytic Zn binding site [ion binding]; other site 272558005730 structural Zn binding site [ion binding]; other site 272558005731 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 272558005732 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 272558005733 Cysteine-rich domain; Region: CCG; pfam02754 272558005734 Cysteine-rich domain; Region: CCG; pfam02754 272558005735 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 272558005736 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272558005737 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272558005738 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 272558005739 Uncharacterized conserved protein [Function unknown]; Region: COG1556 272558005740 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272558005741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558005742 DNA-binding site [nucleotide binding]; DNA binding site 272558005743 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272558005744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558005745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558005746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272558005747 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 272558005748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272558005749 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558005750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272558005751 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272558005752 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272558005753 dimer interface [polypeptide binding]; other site 272558005754 active site 272558005755 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272558005756 active site 272558005757 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272558005758 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272558005759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558005760 NAD(P) binding site [chemical binding]; other site 272558005761 active site 272558005762 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272558005763 classical (c) SDRs; Region: SDR_c; cd05233 272558005764 active site 272558005765 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 272558005766 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272558005767 dimer interface [polypeptide binding]; other site 272558005768 active site 272558005769 CoA binding pocket [chemical binding]; other site 272558005770 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 272558005771 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 272558005772 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272558005773 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 272558005774 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558005775 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 272558005776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558005777 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272558005778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558005779 substrate binding site [chemical binding]; other site 272558005780 oxyanion hole (OAH) forming residues; other site 272558005781 trimer interface [polypeptide binding]; other site 272558005782 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272558005783 hypothetical protein; Provisional; Region: PRK06185 272558005784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558005785 Squalene epoxidase; Region: SE; cl17314 272558005786 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272558005787 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272558005788 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272558005789 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 272558005790 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272558005791 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272558005792 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272558005793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558005794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558005795 DNA binding site [nucleotide binding] 272558005796 domain linker motif; other site 272558005797 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 272558005798 dimerization interface [polypeptide binding]; other site 272558005799 ligand binding site [chemical binding]; other site 272558005800 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272558005801 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558005802 active site turn [active] 272558005803 phosphorylation site [posttranslational modification] 272558005804 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558005805 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 272558005806 putative substrate binding site [chemical binding]; other site 272558005807 putative ATP binding site [chemical binding]; other site 272558005808 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 272558005809 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272558005810 substrate binding [chemical binding]; other site 272558005811 active site 272558005812 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272558005813 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 272558005814 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272558005815 active site 272558005816 metal binding site [ion binding]; metal-binding site 272558005817 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 272558005818 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 272558005819 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 272558005820 active site 272558005821 metal binding site [ion binding]; metal-binding site 272558005822 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558005823 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558005824 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558005825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558005826 dimer interface [polypeptide binding]; other site 272558005827 conserved gate region; other site 272558005828 putative PBP binding loops; other site 272558005829 ABC-ATPase subunit interface; other site 272558005830 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558005831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558005832 dimer interface [polypeptide binding]; other site 272558005833 conserved gate region; other site 272558005834 putative PBP binding loops; other site 272558005835 ABC-ATPase subunit interface; other site 272558005836 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 272558005837 active site 272558005838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558005839 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272558005840 Predicted transcriptional regulator [Transcription]; Region: COG4189 272558005841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558005842 putative DNA binding site [nucleotide binding]; other site 272558005843 dimerization interface [polypeptide binding]; other site 272558005844 putative Zn2+ binding site [ion binding]; other site 272558005845 alpha-galactosidase; Region: PLN02808; cl17638 272558005846 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 272558005847 intersubunit interface [polypeptide binding]; other site 272558005848 active site 272558005849 Zn2+ binding site [ion binding]; other site 272558005850 ribulokinase; Provisional; Region: PRK04123 272558005851 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 272558005852 N- and C-terminal domain interface [polypeptide binding]; other site 272558005853 active site 272558005854 MgATP binding site [chemical binding]; other site 272558005855 catalytic site [active] 272558005856 metal binding site [ion binding]; metal-binding site 272558005857 carbohydrate binding site [chemical binding]; other site 272558005858 homodimer interface [polypeptide binding]; other site 272558005859 L-arabinose isomerase; Provisional; Region: PRK02929 272558005860 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 272558005861 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 272558005862 trimer interface [polypeptide binding]; other site 272558005863 putative substrate binding site [chemical binding]; other site 272558005864 putative metal binding site [ion binding]; other site 272558005865 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 272558005866 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 272558005867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558005868 DNA-binding site [nucleotide binding]; DNA binding site 272558005869 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558005870 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 272558005871 putative dimerization interface [polypeptide binding]; other site 272558005872 putative ligand binding site [chemical binding]; other site 272558005873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 272558005874 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272558005875 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 272558005876 substrate binding site [chemical binding]; other site 272558005877 active site 272558005878 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272558005879 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 272558005880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558005881 Walker A motif; other site 272558005882 ATP binding site [chemical binding]; other site 272558005883 Walker B motif; other site 272558005884 arginine finger; other site 272558005885 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 272558005886 Uncharacterized conserved protein [Function unknown]; Region: COG3535 272558005887 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272558005888 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 272558005889 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272558005890 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 272558005891 Na binding site [ion binding]; other site 272558005892 Uncharacterized conserved protein [Function unknown]; Region: COG3535 272558005893 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272558005894 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 272558005895 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272558005896 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272558005897 synthetase active site [active] 272558005898 NTP binding site [chemical binding]; other site 272558005899 metal binding site [ion binding]; metal-binding site 272558005900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558005901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558005902 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 272558005903 Predicted transcriptional regulator [Transcription]; Region: COG2378 272558005904 HTH domain; Region: HTH_11; pfam08279 272558005905 WYL domain; Region: WYL; pfam13280 272558005906 DinB family; Region: DinB; pfam05163 272558005907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 272558005908 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 272558005909 nudix motif; other site 272558005910 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272558005911 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272558005912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558005913 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558005914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272558005915 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 272558005916 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 272558005917 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272558005918 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 272558005919 catalytic triad [active] 272558005920 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272558005921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272558005922 ABC transporter; Region: ABC_tran_2; pfam12848 272558005923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272558005924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558005925 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 272558005926 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 272558005927 stage II sporulation protein P; Region: spore_II_P; TIGR02867 272558005928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558005929 putative alpha-glucosidase; Provisional; Region: PRK10658 272558005930 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272558005931 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 272558005932 active site 272558005933 homotrimer interface [polypeptide binding]; other site 272558005934 catalytic site [active] 272558005935 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 272558005936 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272558005937 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272558005938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558005939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558005940 Protein of unknown function, DUF624; Region: DUF624; cl02369 272558005941 Probable beta-xylosidase; Provisional; Region: PLN03080 272558005942 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272558005943 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 272558005944 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 272558005945 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 272558005946 ligand binding site [chemical binding]; other site 272558005947 metal binding site [ion binding]; metal-binding site 272558005948 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558005949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558005950 dimerization interface [polypeptide binding]; other site 272558005951 Histidine kinase; Region: His_kinase; pfam06580 272558005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558005953 ATP binding site [chemical binding]; other site 272558005954 Mg2+ binding site [ion binding]; other site 272558005955 G-X-G motif; other site 272558005956 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272558005957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558005958 active site 272558005959 phosphorylation site [posttranslational modification] 272558005960 intermolecular recognition site; other site 272558005961 dimerization interface [polypeptide binding]; other site 272558005962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558005963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558005964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558005965 dimer interface [polypeptide binding]; other site 272558005966 conserved gate region; other site 272558005967 putative PBP binding loops; other site 272558005968 ABC-ATPase subunit interface; other site 272558005969 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558005971 dimer interface [polypeptide binding]; other site 272558005972 conserved gate region; other site 272558005973 ABC-ATPase subunit interface; other site 272558005974 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558005975 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558005976 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 272558005977 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272558005978 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272558005979 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 272558005980 NodB motif; other site 272558005981 active site 272558005982 catalytic site [active] 272558005983 metal binding site [ion binding]; metal-binding site 272558005984 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272558005985 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272558005986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558005987 putative active site [active] 272558005988 heme pocket [chemical binding]; other site 272558005989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558005990 dimer interface [polypeptide binding]; other site 272558005991 phosphorylation site [posttranslational modification] 272558005992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558005993 ATP binding site [chemical binding]; other site 272558005994 Mg2+ binding site [ion binding]; other site 272558005995 G-X-G motif; other site 272558005996 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 272558005997 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272558005998 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272558005999 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 272558006000 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272558006001 beta-galactosidase; Region: BGL; TIGR03356 272558006002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558006003 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272558006004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272558006005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006006 dimer interface [polypeptide binding]; other site 272558006007 conserved gate region; other site 272558006008 putative PBP binding loops; other site 272558006009 ABC-ATPase subunit interface; other site 272558006010 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558006011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006012 dimer interface [polypeptide binding]; other site 272558006013 conserved gate region; other site 272558006014 putative PBP binding loops; other site 272558006015 ABC-ATPase subunit interface; other site 272558006016 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558006017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558006018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558006019 DNA binding site [nucleotide binding] 272558006020 domain linker motif; other site 272558006021 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272558006022 dimerization interface [polypeptide binding]; other site 272558006023 ligand binding site [chemical binding]; other site 272558006024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558006025 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558006026 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558006027 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558006028 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 272558006029 Subtilase family; Region: Peptidase_S8; pfam00082 272558006030 active site 272558006031 catalytic triad [active] 272558006032 EamA-like transporter family; Region: EamA; pfam00892 272558006033 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272558006034 EamA-like transporter family; Region: EamA; pfam00892 272558006035 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 272558006036 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 272558006037 dimer interface [polypeptide binding]; other site 272558006038 acyl-activating enzyme (AAE) consensus motif; other site 272558006039 putative active site [active] 272558006040 AMP binding site [chemical binding]; other site 272558006041 putative CoA binding site [chemical binding]; other site 272558006042 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 272558006043 ThiC-associated domain; Region: ThiC-associated; pfam13667 272558006044 ThiC family; Region: ThiC; pfam01964 272558006045 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558006046 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 272558006047 Spore germination protein; Region: Spore_permease; pfam03845 272558006048 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558006049 EamA-like transporter family; Region: EamA; pfam00892 272558006050 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 272558006051 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 272558006052 Proline dehydrogenase; Region: Pro_dh; pfam01619 272558006053 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272558006054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558006055 DNA-binding site [nucleotide binding]; DNA binding site 272558006056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558006057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558006058 homodimer interface [polypeptide binding]; other site 272558006059 catalytic residue [active] 272558006060 putative disulfide oxidoreductase; Provisional; Region: PRK03113 272558006061 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272558006062 catalytic residues [active] 272558006063 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272558006064 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272558006065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558006066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006067 active site 272558006068 phosphorylation site [posttranslational modification] 272558006069 intermolecular recognition site; other site 272558006070 dimerization interface [polypeptide binding]; other site 272558006071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558006072 DNA binding site [nucleotide binding] 272558006073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558006074 dimerization interface [polypeptide binding]; other site 272558006075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558006076 dimer interface [polypeptide binding]; other site 272558006077 phosphorylation site [posttranslational modification] 272558006078 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272558006079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006080 ATP binding site [chemical binding]; other site 272558006081 Mg2+ binding site [ion binding]; other site 272558006082 G-X-G motif; other site 272558006083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558006084 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558006085 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558006086 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558006087 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272558006088 MgtE intracellular N domain; Region: MgtE_N; pfam03448 272558006089 FOG: CBS domain [General function prediction only]; Region: COG0517 272558006090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272558006091 Divalent cation transporter; Region: MgtE; pfam01769 272558006092 Phosphotransferase enzyme family; Region: APH; pfam01636 272558006093 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272558006094 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272558006095 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272558006096 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272558006097 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272558006098 NAD(P) binding site [chemical binding]; other site 272558006099 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 272558006100 intersubunit interface [polypeptide binding]; other site 272558006101 active site 272558006102 Zn2+ binding site [ion binding]; other site 272558006103 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272558006104 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272558006105 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 272558006106 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 272558006107 Sulfatase; Region: Sulfatase; cl19157 272558006108 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 272558006109 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 272558006110 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272558006111 Helix-turn-helix domain; Region: HTH_18; pfam12833 272558006112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558006113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558006114 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272558006115 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272558006116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558006117 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558006118 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558006119 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558006120 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272558006121 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272558006122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558006123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558006124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558006125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558006126 putative substrate translocation pore; other site 272558006127 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272558006128 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272558006129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558006130 Coenzyme A binding pocket [chemical binding]; other site 272558006131 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 272558006132 Predicted membrane protein [Function unknown]; Region: COG2323 272558006133 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 272558006134 TrkA-N domain; Region: TrkA_N; pfam02254 272558006135 Ion channel; Region: Ion_trans_2; pfam07885 272558006136 Predicted membrane protein [Function unknown]; Region: COG2323 272558006137 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 272558006138 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 272558006139 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272558006140 YIEGIA protein; Region: YIEGIA; pfam14045 272558006141 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272558006142 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272558006143 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272558006144 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 272558006145 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272558006146 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272558006147 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272558006148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272558006149 catalytic loop [active] 272558006150 iron binding site [ion binding]; other site 272558006151 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272558006152 hydroperoxidase II; Provisional; Region: katE; PRK11249 272558006153 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 272558006154 tetramer interface [polypeptide binding]; other site 272558006155 heme binding pocket [chemical binding]; other site 272558006156 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 272558006157 domain interactions; other site 272558006158 anti-terminator HutP; Provisional; Region: hutP; PRK03065 272558006159 hexamer interface [polypeptide binding]; other site 272558006160 RNA binding site [nucleotide binding]; other site 272558006161 Histidine-zinc binding site [chemical binding]; other site 272558006162 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 272558006163 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 272558006164 active sites [active] 272558006165 tetramer interface [polypeptide binding]; other site 272558006166 urocanate hydratase; Provisional; Region: PRK05414 272558006167 imidazolonepropionase; Validated; Region: PRK09356 272558006168 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 272558006169 active site 272558006170 Agmatinase-like family; Region: Agmatinase-like; cd09990 272558006171 active site 272558006172 oligomer interface [polypeptide binding]; other site 272558006173 Mn binding site [ion binding]; other site 272558006174 Predicted permease [General function prediction only]; Region: COG2056 272558006175 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 272558006176 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272558006177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558006178 binding surface 272558006179 TPR motif; other site 272558006180 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558006181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558006182 TPR motif; other site 272558006183 binding surface 272558006184 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558006185 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 272558006186 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 272558006187 Spore germination protein; Region: Spore_permease; pfam03845 272558006188 GAF domain; Region: GAF_3; pfam13492 272558006189 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272558006190 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272558006191 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272558006192 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272558006193 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272558006194 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 272558006195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558006196 substrate binding site [chemical binding]; other site 272558006197 oxyanion hole (OAH) forming residues; other site 272558006198 trimer interface [polypeptide binding]; other site 272558006199 putative acyltransferase; Provisional; Region: PRK05790 272558006200 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272558006201 dimer interface [polypeptide binding]; other site 272558006202 active site 272558006203 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 272558006204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558006205 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272558006206 active site 272558006207 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272558006208 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272558006209 DinB superfamily; Region: DinB_2; pfam12867 272558006210 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 272558006211 Cupin domain; Region: Cupin_2; pfam07883 272558006212 Cupin domain; Region: Cupin_2; pfam07883 272558006213 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 272558006214 Cupin domain; Region: Cupin_2; pfam07883 272558006215 Cupin domain; Region: Cupin_2; pfam07883 272558006216 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272558006217 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272558006218 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272558006219 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 272558006220 acyl-activating enzyme (AAE) consensus motif; other site 272558006221 putative AMP binding site [chemical binding]; other site 272558006222 putative active site [active] 272558006223 putative CoA binding site [chemical binding]; other site 272558006224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 272558006225 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 272558006226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 272558006227 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 272558006228 NAD(P) binding site [chemical binding]; other site 272558006229 catalytic residues [active] 272558006230 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 272558006231 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 272558006232 catalytic Zn binding site [ion binding]; other site 272558006233 NAD binding site [chemical binding]; other site 272558006234 structural Zn binding site [ion binding]; other site 272558006235 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 272558006236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558006237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558006238 dimer interface [polypeptide binding]; other site 272558006239 phosphorylation site [posttranslational modification] 272558006240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006241 ATP binding site [chemical binding]; other site 272558006242 Mg2+ binding site [ion binding]; other site 272558006243 G-X-G motif; other site 272558006244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006245 active site 272558006246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558006247 phosphorylation site [posttranslational modification] 272558006248 intermolecular recognition site; other site 272558006249 dimerization interface [polypeptide binding]; other site 272558006250 Histidine kinase; Region: His_kinase; pfam06580 272558006251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006252 ATP binding site [chemical binding]; other site 272558006253 Mg2+ binding site [ion binding]; other site 272558006254 G-X-G motif; other site 272558006255 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272558006256 Collagen binding domain; Region: Collagen_bind; pfam05737 272558006257 Collagen binding domain; Region: Collagen_bind; pfam05737 272558006258 Collagen binding domain; Region: Collagen_bind; pfam05737 272558006259 Collagen binding domain; Region: Collagen_bind; pfam05737 272558006260 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006261 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006262 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006263 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006264 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006265 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006266 Cna protein B-type domain; Region: Cna_B; pfam05738 272558006267 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 272558006268 active site 272558006269 catalytic site [active] 272558006270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006271 active site 272558006272 phosphorylation site [posttranslational modification] 272558006273 intermolecular recognition site; other site 272558006274 dimerization interface [polypeptide binding]; other site 272558006275 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 272558006276 Bacterial transcriptional activator domain; Region: BTAD; smart01043 272558006277 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558006278 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558006279 DNA binding site [nucleotide binding] 272558006280 domain linker motif; other site 272558006281 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 272558006282 putative dimerization interface [polypeptide binding]; other site 272558006283 putative ligand binding site [chemical binding]; other site 272558006284 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272558006285 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272558006286 Plant organelle RNA recognition domain; Region: PORR; pfam11955 272558006287 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272558006288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006289 dimer interface [polypeptide binding]; other site 272558006290 conserved gate region; other site 272558006291 putative PBP binding loops; other site 272558006292 ABC-ATPase subunit interface; other site 272558006293 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558006294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006295 dimer interface [polypeptide binding]; other site 272558006296 conserved gate region; other site 272558006297 putative PBP binding loops; other site 272558006298 ABC-ATPase subunit interface; other site 272558006299 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272558006300 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272558006301 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272558006302 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 272558006303 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 272558006304 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 272558006305 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272558006306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272558006307 ABC transporter; Region: ABC_tran_2; pfam12848 272558006308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272558006309 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558006310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558006311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558006312 DNA binding residues [nucleotide binding] 272558006313 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 272558006314 Cupredoxin superfamily; Region: Cupredoxin; cl19115 272558006315 putative acyltransferase; Provisional; Region: PRK05790 272558006316 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272558006317 dimer interface [polypeptide binding]; other site 272558006318 active site 272558006319 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272558006320 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 272558006321 Uncharacterized conserved protein [Function unknown]; Region: COG5646 272558006322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558006323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558006324 binding surface 272558006325 TPR motif; other site 272558006326 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006327 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006328 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272558006329 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272558006330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558006331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558006332 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558006333 putative substrate translocation pore; other site 272558006334 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006335 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006336 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558006337 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272558006338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558006339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558006340 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006341 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006342 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006343 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558006344 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006345 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006346 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006347 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006348 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006349 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 272558006350 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 272558006351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558006352 binding surface 272558006353 TPR motif; other site 272558006354 Predicted flavoprotein [General function prediction only]; Region: COG0431 272558006355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558006356 S-adenosylmethionine binding site [chemical binding]; other site 272558006357 DinB superfamily; Region: DinB_2; pfam12867 272558006358 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 272558006359 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 272558006360 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 272558006361 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 272558006362 putative active site [active] 272558006363 putative catalytic site [active] 272558006364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558006365 S-adenosylmethionine binding site [chemical binding]; other site 272558006366 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272558006367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558006368 S-adenosylmethionine binding site [chemical binding]; other site 272558006369 Uncharacterized conserved protein [Function unknown]; Region: COG1683 272558006370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558006371 S-adenosylmethionine binding site [chemical binding]; other site 272558006372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558006373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272558006374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558006375 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 272558006376 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 272558006377 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 272558006378 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 272558006379 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272558006380 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272558006381 D-pathway; other site 272558006382 Putative ubiquinol binding site [chemical binding]; other site 272558006383 Low-spin heme (heme b) binding site [chemical binding]; other site 272558006384 Putative water exit pathway; other site 272558006385 Binuclear center (heme o3/CuB) [ion binding]; other site 272558006386 K-pathway; other site 272558006387 Putative proton exit pathway; other site 272558006388 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 272558006389 Subunit I/III interface [polypeptide binding]; other site 272558006390 Subunit III/IV interface [polypeptide binding]; other site 272558006391 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 272558006392 Predicted membrane protein [Function unknown]; Region: COG2035 272558006393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558006394 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 272558006395 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558006396 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558006397 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 272558006398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558006399 S-adenosylmethionine binding site [chemical binding]; other site 272558006400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 272558006401 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558006402 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 272558006403 substrate binding site [chemical binding]; other site 272558006404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272558006405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006406 dimer interface [polypeptide binding]; other site 272558006407 conserved gate region; other site 272558006408 putative PBP binding loops; other site 272558006409 ABC-ATPase subunit interface; other site 272558006410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272558006411 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 272558006412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006413 dimer interface [polypeptide binding]; other site 272558006414 conserved gate region; other site 272558006415 putative PBP binding loops; other site 272558006416 ABC-ATPase subunit interface; other site 272558006417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558006418 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 272558006419 Walker A/P-loop; other site 272558006420 ATP binding site [chemical binding]; other site 272558006421 Q-loop/lid; other site 272558006422 ABC transporter signature motif; other site 272558006423 Walker B; other site 272558006424 D-loop; other site 272558006425 H-loop/switch region; other site 272558006426 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272558006427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558006428 Walker A/P-loop; other site 272558006429 ATP binding site [chemical binding]; other site 272558006430 Q-loop/lid; other site 272558006431 ABC transporter signature motif; other site 272558006432 Walker B; other site 272558006433 D-loop; other site 272558006434 H-loop/switch region; other site 272558006435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558006436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558006437 putative substrate translocation pore; other site 272558006438 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 272558006439 Subtilase family; Region: Peptidase_S8; pfam00082 272558006440 active site 272558006441 catalytic triad [active] 272558006442 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272558006443 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272558006444 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272558006445 The first cupredoxin domain of bacteria two domain multicopper oxidase; Region: CuRO_1_2dMco_1; cd13860 272558006446 putative trimer interface [polypeptide binding]; other site 272558006447 trinuclear Cu binding site [ion binding]; other site 272558006448 Cupredoxin superfamily; Region: Cupredoxin; cl19115 272558006449 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 272558006450 trimer interface [polypeptide binding]; other site 272558006451 trinuclear Cu binding site [ion binding]; other site 272558006452 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 272558006453 putative dimer interface [polypeptide binding]; other site 272558006454 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 272558006455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272558006456 DoxX-like family; Region: DoxX_2; pfam13564 272558006457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558006458 dimerization interface [polypeptide binding]; other site 272558006459 putative DNA binding site [nucleotide binding]; other site 272558006460 putative Zn2+ binding site [ion binding]; other site 272558006461 Uncharacterized conserved protein [Function unknown]; Region: COG3832 272558006462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 272558006463 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 272558006464 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 272558006465 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272558006466 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272558006467 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 272558006468 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 272558006469 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 272558006470 active site residue [active] 272558006471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558006472 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558006473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558006474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272558006475 dimerization interface [polypeptide binding]; other site 272558006476 Pleckstrin homology-like domain; Region: PH-like; cl17171 272558006477 YvbH-like oligomerization region; Region: YvbH_ext; pfam11724 272558006478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558006479 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 272558006480 Histidine kinase; Region: HisKA_3; pfam07730 272558006481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558006482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006483 active site 272558006484 phosphorylation site [posttranslational modification] 272558006485 intermolecular recognition site; other site 272558006486 dimerization interface [polypeptide binding]; other site 272558006487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558006488 DNA binding residues [nucleotide binding] 272558006489 dimerization interface [polypeptide binding]; other site 272558006490 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558006491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558006492 Walker A/P-loop; other site 272558006493 ATP binding site [chemical binding]; other site 272558006494 Q-loop/lid; other site 272558006495 ABC transporter signature motif; other site 272558006496 Walker B; other site 272558006497 D-loop; other site 272558006498 H-loop/switch region; other site 272558006499 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272558006500 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272558006501 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272558006502 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272558006503 glutamate dehydrogenase; Provisional; Region: PRK09414 272558006504 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558006505 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 272558006506 NAD(P) binding site [chemical binding]; other site 272558006507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558006508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272558006509 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 272558006510 putative dimerization interface [polypeptide binding]; other site 272558006511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558006512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558006513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558006514 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558006515 Coenzyme A binding pocket [chemical binding]; other site 272558006516 Endoglucanase Y [Carbohydrate transport and metabolism]; Region: CelA; COG3405 272558006517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558006518 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558006519 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272558006520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006521 active site 272558006522 phosphorylation site [posttranslational modification] 272558006523 intermolecular recognition site; other site 272558006524 dimerization interface [polypeptide binding]; other site 272558006525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558006526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558006527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558006528 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558006529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558006530 dimerization interface [polypeptide binding]; other site 272558006531 Histidine kinase; Region: His_kinase; pfam06580 272558006532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006533 ATP binding site [chemical binding]; other site 272558006534 Mg2+ binding site [ion binding]; other site 272558006535 G-X-G motif; other site 272558006536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558006537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558006538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006539 dimer interface [polypeptide binding]; other site 272558006540 conserved gate region; other site 272558006541 ABC-ATPase subunit interface; other site 272558006542 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558006543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006544 dimer interface [polypeptide binding]; other site 272558006545 conserved gate region; other site 272558006546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272558006547 ABC-ATPase subunit interface; other site 272558006548 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 272558006549 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272558006550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558006551 putative substrate translocation pore; other site 272558006552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558006553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272558006554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272558006555 dimerization interface [polypeptide binding]; other site 272558006556 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272558006557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558006558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558006559 DNA binding residues [nucleotide binding] 272558006560 dimerization interface [polypeptide binding]; other site 272558006561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558006562 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 272558006563 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558006564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558006565 hypothetical protein; Provisional; Region: PRK10621 272558006566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558006567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006568 active site 272558006569 phosphorylation site [posttranslational modification] 272558006570 intermolecular recognition site; other site 272558006571 dimerization interface [polypeptide binding]; other site 272558006572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558006573 DNA binding residues [nucleotide binding] 272558006574 dimerization interface [polypeptide binding]; other site 272558006575 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558006576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558006577 non-specific DNA binding site [nucleotide binding]; other site 272558006578 salt bridge; other site 272558006579 sequence-specific DNA binding site [nucleotide binding]; other site 272558006580 Anti-repressor SinI; Region: SinI; pfam08671 272558006581 Anti-repressor SinI; Region: SinI; pfam08671 272558006582 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 272558006583 active site 272558006584 catalytic site [active] 272558006585 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272558006586 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 272558006587 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272558006588 Catalytic site [active] 272558006589 YqxM protein; Region: YqxM_for_SipW; TIGR04087 272558006590 L-lactate permease; Region: Lactate_perm; cl00701 272558006591 malate synthase G; Provisional; Region: PRK02999 272558006592 active site 272558006593 FAD binding domain; Region: FAD_binding_4; pfam01565 272558006594 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272558006595 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272558006596 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272558006597 Cysteine-rich domain; Region: CCG; pfam02754 272558006598 Cysteine-rich domain; Region: CCG; pfam02754 272558006599 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272558006600 FAD binding domain; Region: FAD_binding_4; pfam01565 272558006601 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272558006602 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272558006603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272558006604 Bacterial transcriptional regulator; Region: IclR; pfam01614 272558006605 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 272558006606 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272558006607 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272558006608 CAP-like domain; other site 272558006609 active site 272558006610 primary dimer interface [polypeptide binding]; other site 272558006611 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558006612 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558006613 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272558006614 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272558006615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006616 ATP binding site [chemical binding]; other site 272558006617 Mg2+ binding site [ion binding]; other site 272558006618 G-X-G motif; other site 272558006619 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272558006620 anchoring element; other site 272558006621 dimer interface [polypeptide binding]; other site 272558006622 ATP binding site [chemical binding]; other site 272558006623 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272558006624 active site 272558006625 metal binding site [ion binding]; metal-binding site 272558006626 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272558006627 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272558006628 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 272558006629 active site 272558006630 metal binding site [ion binding]; metal-binding site 272558006631 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 272558006632 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 272558006633 short chain dehydrogenase; Provisional; Region: PRK07677 272558006634 NAD(P) binding site [chemical binding]; other site 272558006635 substrate binding site [chemical binding]; other site 272558006636 homotetramer interface [polypeptide binding]; other site 272558006637 active site 272558006638 homodimer interface [polypeptide binding]; other site 272558006639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558006640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558006641 Predicted membrane protein [Function unknown]; Region: COG1511 272558006642 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272558006643 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272558006644 dimer interface [polypeptide binding]; other site 272558006645 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272558006646 dimer interface [polypeptide binding]; other site 272558006647 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 272558006648 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 272558006649 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272558006650 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272558006651 active site 272558006652 Zn binding site [ion binding]; other site 272558006653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 272558006654 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 272558006655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558006656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558006657 Coenzyme A binding pocket [chemical binding]; other site 272558006658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558006659 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558006660 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272558006661 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 272558006662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558006663 motif II; other site 272558006664 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272558006665 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272558006666 homodimer interface [polypeptide binding]; other site 272558006667 substrate-cofactor binding pocket; other site 272558006668 catalytic residue [active] 272558006669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272558006670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558006671 Coenzyme A binding pocket [chemical binding]; other site 272558006672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272558006673 active site 272558006674 catalytic tetrad [active] 272558006675 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 272558006676 putative dimer interface [polypeptide binding]; other site 272558006677 ligand binding site [chemical binding]; other site 272558006678 Zn binding site [ion binding]; other site 272558006679 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272558006680 active site 272558006681 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272558006682 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272558006683 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558006684 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272558006685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558006686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558006687 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558006688 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 272558006689 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 272558006690 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 272558006691 NADP binding site [chemical binding]; other site 272558006692 homodimer interface [polypeptide binding]; other site 272558006693 active site 272558006694 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272558006695 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272558006696 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272558006697 LysE type translocator; Region: LysE; pfam01810 272558006698 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272558006699 Spore germination protein; Region: Spore_permease; cl17796 272558006700 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272558006701 Predicted esterase [General function prediction only]; Region: COG0400 272558006702 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558006703 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272558006704 Zn binding site [ion binding]; other site 272558006705 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272558006706 Zn binding site [ion binding]; other site 272558006707 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558006708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558006709 putative Zn2+ binding site [ion binding]; other site 272558006710 putative DNA binding site [nucleotide binding]; other site 272558006711 EamA-like transporter family; Region: EamA; pfam00892 272558006712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272558006713 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 272558006714 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272558006715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558006716 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272558006717 Walker A motif; other site 272558006718 ATP binding site [chemical binding]; other site 272558006719 Walker B motif; other site 272558006720 arginine finger; other site 272558006721 UvrB/uvrC motif; Region: UVR; pfam02151 272558006722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558006723 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272558006724 Walker A motif; other site 272558006725 ATP binding site [chemical binding]; other site 272558006726 Walker B motif; other site 272558006727 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272558006728 5'-3' exonuclease; Region: 53EXOc; smart00475 272558006729 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272558006730 active site 272558006731 metal binding site 1 [ion binding]; metal-binding site 272558006732 putative 5' ssDNA interaction site; other site 272558006733 metal binding site 3; metal-binding site 272558006734 metal binding site 2 [ion binding]; metal-binding site 272558006735 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272558006736 putative DNA binding site [nucleotide binding]; other site 272558006737 putative metal binding site [ion binding]; other site 272558006738 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 272558006739 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 272558006740 Subtilase family; Region: Peptidase_S8; pfam00082 272558006741 active site 272558006742 catalytic residues [active] 272558006743 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 272558006744 conserved hypothetical tiny transmembrane protein; Region: tiny_TM_bacill; TIGR01732 272558006745 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 272558006746 Spore germination protein; Region: Spore_permease; pfam03845 272558006747 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272558006748 Trypsin; Region: Trypsin; pfam00089 272558006749 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272558006750 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272558006751 dimanganese center [ion binding]; other site 272558006752 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 272558006753 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 272558006754 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272558006755 Uncharacterized conserved protein [Function unknown]; Region: COG3342 272558006756 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 272558006757 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 272558006758 aspartate aminotransferase; Provisional; Region: PRK06836 272558006759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558006760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558006761 homodimer interface [polypeptide binding]; other site 272558006762 catalytic residue [active] 272558006763 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272558006764 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272558006765 active site 272558006766 HIGH motif; other site 272558006767 dimer interface [polypeptide binding]; other site 272558006768 KMSKS motif; other site 272558006769 Predicted membrane protein [Function unknown]; Region: COG2323 272558006770 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272558006771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558006772 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558006773 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558006774 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558006775 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272558006776 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272558006777 E3 interaction surface; other site 272558006778 lipoyl attachment site [posttranslational modification]; other site 272558006779 e3 binding domain; Region: E3_binding; pfam02817 272558006780 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558006781 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272558006782 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272558006783 TPP-binding site [chemical binding]; other site 272558006784 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272558006785 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272558006786 dimer interface [polypeptide binding]; other site 272558006787 PYR/PP interface [polypeptide binding]; other site 272558006788 TPP binding site [chemical binding]; other site 272558006789 DsrC like protein; Region: DsrC; cl01101 272558006790 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 272558006791 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 272558006792 putative DNA binding site [nucleotide binding]; other site 272558006793 putative homodimer interface [polypeptide binding]; other site 272558006794 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 272558006795 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 272558006796 active site 272558006797 DNA binding site [nucleotide binding] 272558006798 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 272558006799 DNA binding site [nucleotide binding] 272558006800 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 272558006801 nucleotide binding site [chemical binding]; other site 272558006802 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272558006803 classical (c) SDRs; Region: SDR_c; cd05233 272558006804 NAD(P) binding site [chemical binding]; other site 272558006805 active site 272558006806 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 272558006807 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272558006808 active site 272558006809 metal binding site [ion binding]; metal-binding site 272558006810 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558006811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006812 active site 272558006813 phosphorylation site [posttranslational modification] 272558006814 intermolecular recognition site; other site 272558006815 dimerization interface [polypeptide binding]; other site 272558006816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558006817 DNA binding residues [nucleotide binding] 272558006818 dimerization interface [polypeptide binding]; other site 272558006819 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272558006820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558006821 Histidine kinase; Region: HisKA_3; pfam07730 272558006822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006823 ATP binding site [chemical binding]; other site 272558006824 Mg2+ binding site [ion binding]; other site 272558006825 G-X-G motif; other site 272558006826 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 272558006827 active site 272558006828 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 272558006829 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558006830 active site turn [active] 272558006831 phosphorylation site [posttranslational modification] 272558006832 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558006833 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272558006834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558006835 FeS/SAM binding site; other site 272558006836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558006837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558006838 DNA binding site [nucleotide binding] 272558006839 domain linker motif; other site 272558006840 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272558006841 dimerization interface [polypeptide binding]; other site 272558006842 ligand binding site [chemical binding]; other site 272558006843 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558006844 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558006845 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558006846 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558006847 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558006848 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558006849 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 272558006850 Na binding site [ion binding]; other site 272558006851 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 272558006852 Melibiase; Region: Melibiase; pfam02065 272558006853 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558006854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006855 dimer interface [polypeptide binding]; other site 272558006856 conserved gate region; other site 272558006857 putative PBP binding loops; other site 272558006858 ABC-ATPase subunit interface; other site 272558006859 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272558006860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558006861 dimer interface [polypeptide binding]; other site 272558006862 conserved gate region; other site 272558006863 putative PBP binding loops; other site 272558006864 ABC-ATPase subunit interface; other site 272558006865 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558006866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558006867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558006868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558006869 DNA binding site [nucleotide binding] 272558006870 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 272558006871 putative dimerization interface [polypeptide binding]; other site 272558006872 putative ligand binding site [chemical binding]; other site 272558006873 alpha-galactosidase; Provisional; Region: PRK15076 272558006874 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 272558006875 NAD binding site [chemical binding]; other site 272558006876 sugar binding site [chemical binding]; other site 272558006877 divalent metal binding site [ion binding]; other site 272558006878 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272558006879 dimer interface [polypeptide binding]; other site 272558006880 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272558006881 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272558006882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558006883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558006884 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272558006885 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272558006886 DXD motif; other site 272558006887 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 272558006888 HEAT repeats; Region: HEAT_2; pfam13646 272558006889 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 272558006890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272558006891 metal binding site [ion binding]; metal-binding site 272558006892 active site 272558006893 I-site; other site 272558006894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006895 active site 272558006896 phosphorylation site [posttranslational modification] 272558006897 intermolecular recognition site; other site 272558006898 dimerization interface [polypeptide binding]; other site 272558006899 response regulator PleD; Reviewed; Region: pleD; PRK09581 272558006900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006901 active site 272558006902 phosphorylation site [posttranslational modification] 272558006903 intermolecular recognition site; other site 272558006904 dimerization interface [polypeptide binding]; other site 272558006905 Mediator complex subunit 28; Region: Med28; pfam11594 272558006906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272558006907 metal binding site [ion binding]; metal-binding site 272558006908 active site 272558006909 I-site; other site 272558006910 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272558006911 dimer interface [polypeptide binding]; other site 272558006912 FMN binding site [chemical binding]; other site 272558006913 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 272558006914 tetrameric interface [polypeptide binding]; other site 272558006915 activator binding site; other site 272558006916 NADP binding site [chemical binding]; other site 272558006917 substrate binding site [chemical binding]; other site 272558006918 catalytic residues [active] 272558006919 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272558006920 active site 272558006921 YusW-like protein; Region: YusW; pfam14039 272558006922 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 272558006923 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 272558006924 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 272558006925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558006926 FeS/SAM binding site; other site 272558006927 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 272558006928 active site 272558006929 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272558006930 Ligand Binding Site [chemical binding]; other site 272558006931 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 272558006932 Uncharacterized conserved protein [Function unknown]; Region: COG2968 272558006933 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558006934 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272558006935 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 272558006936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 272558006937 Nucleoside recognition; Region: Gate; pfam07670 272558006938 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 272558006939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 272558006940 Predicted membrane protein [Function unknown]; Region: COG2259 272558006941 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 272558006942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558006943 FeS/SAM binding site; other site 272558006944 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 272558006945 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 272558006946 toxin interface [polypeptide binding]; other site 272558006947 Zn binding site [ion binding]; other site 272558006948 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 272558006949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558006950 Coenzyme A binding pocket [chemical binding]; other site 272558006951 Coenzyme A transferase; Region: CoA_trans; cl17247 272558006952 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272558006953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558006954 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558006955 inhibitor-cofactor binding pocket; inhibition site 272558006956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558006957 catalytic residue [active] 272558006958 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272558006959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558006960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006961 active site 272558006962 phosphorylation site [posttranslational modification] 272558006963 intermolecular recognition site; other site 272558006964 dimerization interface [polypeptide binding]; other site 272558006965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558006966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558006967 dimerization interface [polypeptide binding]; other site 272558006968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558006969 dimer interface [polypeptide binding]; other site 272558006970 phosphorylation site [posttranslational modification] 272558006971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558006972 ATP binding site [chemical binding]; other site 272558006973 Mg2+ binding site [ion binding]; other site 272558006974 G-X-G motif; other site 272558006975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558006976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558006977 active site 272558006978 phosphorylation site [posttranslational modification] 272558006979 intermolecular recognition site; other site 272558006980 dimerization interface [polypeptide binding]; other site 272558006981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558006982 DNA binding site [nucleotide binding] 272558006983 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272558006984 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 272558006985 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558006986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558006987 Walker A/P-loop; other site 272558006988 ATP binding site [chemical binding]; other site 272558006989 Q-loop/lid; other site 272558006990 ABC transporter signature motif; other site 272558006991 Walker B; other site 272558006992 D-loop; other site 272558006993 H-loop/switch region; other site 272558006994 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 272558006995 active site 272558006996 dimer interface [polypeptide binding]; other site 272558006997 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272558006998 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272558006999 putative dimer interface [polypeptide binding]; other site 272558007000 YppG-like protein; Region: YppG; pfam14179 272558007001 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 272558007002 Cache domain; Region: Cache_1; pfam02743 272558007003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558007004 dimerization interface [polypeptide binding]; other site 272558007005 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558007006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272558007007 dimer interface [polypeptide binding]; other site 272558007008 putative CheW interface [polypeptide binding]; other site 272558007009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558007010 putative substrate translocation pore; other site 272558007011 sugar efflux transporter; Region: 2A0120; TIGR00899 272558007012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272558007013 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 272558007014 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272558007015 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558007016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272558007017 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272558007018 proposed active site lysine [active] 272558007019 conserved cys residue [active] 272558007020 hypothetical protein; Validated; Region: PRK07708 272558007021 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 272558007022 RNA/DNA hybrid binding site [nucleotide binding]; other site 272558007023 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 272558007024 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272558007025 active site 272558007026 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 272558007027 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272558007028 homodimer interface [polypeptide binding]; other site 272558007029 NAD binding pocket [chemical binding]; other site 272558007030 ATP binding pocket [chemical binding]; other site 272558007031 Mg binding site [ion binding]; other site 272558007032 active-site loop [active] 272558007033 small, acid-soluble spore protein tlp; Region: SASP_tlp; TIGR03090 272558007034 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272558007035 active site 272558007036 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 272558007037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558007038 Walker A motif; other site 272558007039 ATP binding site [chemical binding]; other site 272558007040 Walker B motif; other site 272558007041 arginine finger; other site 272558007042 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 272558007043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558007044 Walker A motif; other site 272558007045 ATP binding site [chemical binding]; other site 272558007046 Walker B motif; other site 272558007047 arginine finger; other site 272558007048 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 272558007049 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 272558007050 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 272558007051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558007052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558007053 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 272558007054 active site 272558007055 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272558007056 VanZ like family; Region: VanZ; pfam04892 272558007057 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 272558007058 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 272558007059 Predicted membrane protein [Function unknown]; Region: COG2323 272558007060 aconitate hydratase; Validated; Region: PRK09277 272558007061 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272558007062 substrate binding site [chemical binding]; other site 272558007063 ligand binding site [chemical binding]; other site 272558007064 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272558007065 substrate binding site [chemical binding]; other site 272558007066 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 272558007067 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 272558007068 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272558007069 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272558007070 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272558007071 active site 272558007072 tetramer interface; other site 272558007073 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272558007074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558007075 NAD(P) binding site [chemical binding]; other site 272558007076 active site 272558007077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558007078 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272558007079 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272558007080 Predicted membrane protein [Function unknown]; Region: COG1288 272558007081 allantoinase; Provisional; Region: PRK06189 272558007082 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558007083 active site 272558007084 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272558007085 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272558007086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558007087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558007088 putative substrate translocation pore; other site 272558007089 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 272558007090 tetrameric interface [polypeptide binding]; other site 272558007091 NAD binding site [chemical binding]; other site 272558007092 catalytic residues [active] 272558007093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558007094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558007095 DNA binding site [nucleotide binding] 272558007096 domain linker motif; other site 272558007097 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 272558007098 dimerization interface [polypeptide binding]; other site 272558007099 ligand binding site [chemical binding]; other site 272558007100 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272558007101 intersubunit interface [polypeptide binding]; other site 272558007102 active site 272558007103 zinc binding site [ion binding]; other site 272558007104 Na+ binding site [ion binding]; other site 272558007105 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272558007106 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272558007107 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558007108 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558007109 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558007110 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272558007111 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272558007112 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 272558007113 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272558007114 PYR/PP interface [polypeptide binding]; other site 272558007115 dimer interface [polypeptide binding]; other site 272558007116 TPP binding site [chemical binding]; other site 272558007117 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272558007118 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 272558007119 TPP-binding site; other site 272558007120 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272558007121 substrate binding site [chemical binding]; other site 272558007122 ATP binding site [chemical binding]; other site 272558007123 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 272558007124 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272558007125 TM-ABC transporter signature motif; other site 272558007126 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272558007127 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272558007128 Walker A/P-loop; other site 272558007129 ATP binding site [chemical binding]; other site 272558007130 Q-loop/lid; other site 272558007131 ABC transporter signature motif; other site 272558007132 Walker B; other site 272558007133 D-loop; other site 272558007134 H-loop/switch region; other site 272558007135 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272558007136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272558007137 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 272558007138 putative ligand binding site [chemical binding]; other site 272558007139 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 272558007140 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 272558007141 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 272558007142 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272558007143 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272558007144 hexamer interface [polypeptide binding]; other site 272558007145 ligand binding site [chemical binding]; other site 272558007146 putative active site [active] 272558007147 NAD(P) binding site [chemical binding]; other site 272558007148 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558007149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558007150 S-adenosylmethionine binding site [chemical binding]; other site 272558007151 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 272558007152 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 272558007153 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 272558007154 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 272558007155 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558007156 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272558007157 Walker A/P-loop; other site 272558007158 ATP binding site [chemical binding]; other site 272558007159 Q-loop/lid; other site 272558007160 ABC transporter signature motif; other site 272558007161 Walker B; other site 272558007162 D-loop; other site 272558007163 H-loop/switch region; other site 272558007164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558007165 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 272558007166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558007167 Walker A/P-loop; other site 272558007168 ATP binding site [chemical binding]; other site 272558007169 Q-loop/lid; other site 272558007170 ABC transporter signature motif; other site 272558007171 Walker B; other site 272558007172 D-loop; other site 272558007173 H-loop/switch region; other site 272558007174 Haemagglutinin; Region: Hemagglutinin; pfam00509 272558007175 Haemagglutinin; Region: Hemagglutinin; pfam00509 272558007176 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 272558007177 Pre-toxin TG; Region: PT-TG; pfam14449 272558007178 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 272558007179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272558007180 Transposase; Region: HTH_Tnp_1; cl17663 272558007181 putative transposase OrfB; Reviewed; Region: PHA02517 272558007182 HTH-like domain; Region: HTH_21; pfam13276 272558007183 Integrase core domain; Region: rve; pfam00665 272558007184 Integrase core domain; Region: rve_3; pfam13683 272558007185 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558007186 LXG domain of WXG superfamily; Region: LXG; pfam04740 272558007187 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272558007188 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272558007189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 272558007190 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 272558007191 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272558007192 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272558007193 TPP-binding site [chemical binding]; other site 272558007194 dimer interface [polypeptide binding]; other site 272558007195 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272558007196 PYR/PP interface [polypeptide binding]; other site 272558007197 dimer interface [polypeptide binding]; other site 272558007198 TPP binding site [chemical binding]; other site 272558007199 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558007200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 272558007201 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272558007202 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272558007203 catalytic residues [active] 272558007204 catalytic nucleophile [active] 272558007205 LexA repressor; Validated; Region: PRK00215 272558007206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558007207 putative DNA binding site [nucleotide binding]; other site 272558007208 putative Zn2+ binding site [ion binding]; other site 272558007209 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272558007210 Catalytic site [active] 272558007211 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272558007212 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 272558007213 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272558007214 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272558007215 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272558007216 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 272558007217 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272558007218 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272558007219 HflX GTPase family; Region: HflX; cd01878 272558007220 G1 box; other site 272558007221 GTP/Mg2+ binding site [chemical binding]; other site 272558007222 Switch I region; other site 272558007223 G2 box; other site 272558007224 G3 box; other site 272558007225 Switch II region; other site 272558007226 G4 box; other site 272558007227 G5 box; other site 272558007228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558007229 Walker A motif; other site 272558007230 ATP binding site [chemical binding]; other site 272558007231 Walker B motif; other site 272558007232 arginine finger; other site 272558007233 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 272558007234 integron integrase; Region: integrase_gron; TIGR02249 272558007235 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272558007236 active site 272558007237 catalytic residues [active] 272558007238 DNA binding site [nucleotide binding] 272558007239 Int/Topo IB signature motif; other site 272558007240 bacterial Hfq-like; Region: Hfq; cd01716 272558007241 hexamer interface [polypeptide binding]; other site 272558007242 Sm1 motif; other site 272558007243 RNA binding site [nucleotide binding]; other site 272558007244 Sm2 motif; other site 272558007245 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272558007246 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 272558007247 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272558007248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558007249 ATP binding site [chemical binding]; other site 272558007250 Mg2+ binding site [ion binding]; other site 272558007251 G-X-G motif; other site 272558007252 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272558007253 ATP binding site [chemical binding]; other site 272558007254 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272558007255 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272558007256 MutS domain I; Region: MutS_I; pfam01624 272558007257 MutS domain II; Region: MutS_II; pfam05188 272558007258 MutS domain III; Region: MutS_III; pfam05192 272558007259 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272558007260 Walker A/P-loop; other site 272558007261 ATP binding site [chemical binding]; other site 272558007262 Q-loop/lid; other site 272558007263 ABC transporter signature motif; other site 272558007264 Walker B; other site 272558007265 D-loop; other site 272558007266 H-loop/switch region; other site 272558007267 Outer spore coat protein E (CotE); Region: CotE; pfam10628 272558007268 Predicted membrane protein [Function unknown]; Region: COG4550 272558007269 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 272558007270 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272558007271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558007272 FeS/SAM binding site; other site 272558007273 TRAM domain; Region: TRAM; pfam01938 272558007274 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 272558007275 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 272558007276 TPP-binding site [chemical binding]; other site 272558007277 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 272558007278 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 272558007279 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 272558007280 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272558007281 dimer interface [polypeptide binding]; other site 272558007282 PYR/PP interface [polypeptide binding]; other site 272558007283 TPP binding site [chemical binding]; other site 272558007284 substrate binding site [chemical binding]; other site 272558007285 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 272558007286 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272558007287 putative active site [active] 272558007288 metal binding site [ion binding]; metal-binding site 272558007289 homodimer binding site [polypeptide binding]; other site 272558007290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558007291 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558007292 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558007293 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558007294 phosphodiesterase; Provisional; Region: PRK12704 272558007295 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 272558007296 KH domain; Region: KH_1; pfam00013 272558007297 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558007298 Zn2+ binding site [ion binding]; other site 272558007299 Mg2+ binding site [ion binding]; other site 272558007300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558007301 Walker B; other site 272558007302 D-loop; other site 272558007303 H-loop/switch region; other site 272558007304 Protein of unknown function (DUF342); Region: DUF342; cl19219 272558007305 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272558007306 AAA domain; Region: AAA_23; pfam13476 272558007307 Walker A/P-loop; other site 272558007308 ATP binding site [chemical binding]; other site 272558007309 Q-loop/lid; other site 272558007310 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272558007311 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272558007312 active site 272558007313 metal binding site [ion binding]; metal-binding site 272558007314 DNA binding site [nucleotide binding] 272558007315 recombinase A; Provisional; Region: recA; PRK09354 272558007316 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272558007317 hexamer interface [polypeptide binding]; other site 272558007318 Walker A motif; other site 272558007319 ATP binding site [chemical binding]; other site 272558007320 Walker B motif; other site 272558007321 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272558007322 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272558007323 ATP binding site [chemical binding]; other site 272558007324 Mg++ binding site [ion binding]; other site 272558007325 motif III; other site 272558007326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558007327 nucleotide binding region [chemical binding]; other site 272558007328 ATP-binding site [chemical binding]; other site 272558007329 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 272558007330 RNA binding site [nucleotide binding]; other site 272558007331 competence damage-inducible protein A; Provisional; Region: PRK00549 272558007332 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272558007333 putative MPT binding site; other site 272558007334 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 272558007335 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 272558007336 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 272558007337 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272558007338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558007339 non-specific DNA binding site [nucleotide binding]; other site 272558007340 salt bridge; other site 272558007341 sequence-specific DNA binding site [nucleotide binding]; other site 272558007342 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272558007343 ACT domain; Region: ACT; pfam01842 272558007344 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 272558007345 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 272558007346 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272558007347 classical (c) SDRs; Region: SDR_c; cd05233 272558007348 NAD(P) binding site [chemical binding]; other site 272558007349 active site 272558007350 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272558007351 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272558007352 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272558007353 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272558007354 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272558007355 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272558007356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558007357 DNA-binding site [nucleotide binding]; DNA binding site 272558007358 UTRA domain; Region: UTRA; pfam07702 272558007359 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272558007360 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272558007361 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272558007362 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272558007363 YlzJ-like protein; Region: YlzJ; pfam14035 272558007364 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272558007365 active site 272558007366 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272558007367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272558007368 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272558007369 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272558007370 dimer interface [polypeptide binding]; other site 272558007371 active site 272558007372 catalytic residue [active] 272558007373 aspartate kinase I; Reviewed; Region: PRK08210 272558007374 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272558007375 nucleotide binding site [chemical binding]; other site 272558007376 substrate binding site [chemical binding]; other site 272558007377 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 272558007378 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272558007379 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272558007380 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272558007381 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272558007382 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 272558007383 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 272558007384 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 272558007385 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272558007386 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 272558007387 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 272558007388 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272558007389 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272558007390 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272558007391 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 272558007392 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 272558007393 NodB motif; other site 272558007394 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272558007395 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272558007396 RNase E interface [polypeptide binding]; other site 272558007397 trimer interface [polypeptide binding]; other site 272558007398 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272558007399 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272558007400 RNase E interface [polypeptide binding]; other site 272558007401 trimer interface [polypeptide binding]; other site 272558007402 active site 272558007403 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272558007404 putative nucleic acid binding region [nucleotide binding]; other site 272558007405 G-X-X-G motif; other site 272558007406 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272558007407 RNA binding site [nucleotide binding]; other site 272558007408 domain interface; other site 272558007409 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272558007410 16S/18S rRNA binding site [nucleotide binding]; other site 272558007411 S13e-L30e interaction site [polypeptide binding]; other site 272558007412 25S rRNA binding site [nucleotide binding]; other site 272558007413 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272558007414 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272558007415 active site 272558007416 Riboflavin kinase; Region: Flavokinase; pfam01687 272558007417 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 272558007418 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272558007419 RNA binding site [nucleotide binding]; other site 272558007420 active site 272558007421 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272558007422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 272558007423 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272558007424 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272558007425 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272558007426 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272558007427 G1 box; other site 272558007428 putative GEF interaction site [polypeptide binding]; other site 272558007429 GTP/Mg2+ binding site [chemical binding]; other site 272558007430 Switch I region; other site 272558007431 G2 box; other site 272558007432 G3 box; other site 272558007433 Switch II region; other site 272558007434 G4 box; other site 272558007435 G5 box; other site 272558007436 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272558007437 Translation-initiation factor 2; Region: IF-2; pfam11987 272558007438 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272558007439 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272558007440 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272558007441 putative RNA binding cleft [nucleotide binding]; other site 272558007442 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272558007443 NusA N-terminal domain; Region: NusA_N; pfam08529 272558007444 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272558007445 RNA binding site [nucleotide binding]; other site 272558007446 homodimer interface [polypeptide binding]; other site 272558007447 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272558007448 G-X-X-G motif; other site 272558007449 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272558007450 G-X-X-G motif; other site 272558007451 Sm and related proteins; Region: Sm_like; cl00259 272558007452 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272558007453 putative oligomer interface [polypeptide binding]; other site 272558007454 putative RNA binding site [nucleotide binding]; other site 272558007455 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272558007456 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 272558007457 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 272558007458 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272558007459 generic binding surface II; other site 272558007460 generic binding surface I; other site 272558007461 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272558007462 active site 272558007463 putative PHP Thumb interface [polypeptide binding]; other site 272558007464 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272558007465 active site 272558007466 catalytic site [active] 272558007467 substrate binding site [chemical binding]; other site 272558007468 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272558007469 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272558007470 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272558007471 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272558007472 dimer interface [polypeptide binding]; other site 272558007473 motif 1; other site 272558007474 active site 272558007475 motif 2; other site 272558007476 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272558007477 putative deacylase active site [active] 272558007478 motif 3; other site 272558007479 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272558007480 anticodon binding site; other site 272558007481 RIP metalloprotease RseP; Region: TIGR00054 272558007482 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272558007483 active site 272558007484 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272558007485 protein binding site [polypeptide binding]; other site 272558007486 putative substrate binding region [chemical binding]; other site 272558007487 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272558007488 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272558007489 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272558007490 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272558007491 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272558007492 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272558007493 active site 272558007494 dimer interface [polypeptide binding]; other site 272558007495 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272558007496 hinge region; other site 272558007497 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272558007498 putative nucleotide binding site [chemical binding]; other site 272558007499 uridine monophosphate binding site [chemical binding]; other site 272558007500 homohexameric interface [polypeptide binding]; other site 272558007501 elongation factor Ts; Provisional; Region: tsf; PRK09377 272558007502 UBA/TS-N domain; Region: UBA; pfam00627 272558007503 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272558007504 rRNA interaction site [nucleotide binding]; other site 272558007505 S8 interaction site; other site 272558007506 putative laminin-1 binding site; other site 272558007507 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 272558007508 Uncharacterized conserved protein [Function unknown]; Region: COG1315 272558007509 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 272558007510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558007511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272558007512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558007513 DNA binding residues [nucleotide binding] 272558007514 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 272558007515 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 272558007516 CheC-like family; Region: CheC; pfam04509 272558007517 CheC-like family; Region: CheC; pfam04509 272558007518 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272558007519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558007520 active site 272558007521 phosphorylation site [posttranslational modification] 272558007522 intermolecular recognition site; other site 272558007523 dimerization interface [polypeptide binding]; other site 272558007524 CheB methylesterase; Region: CheB_methylest; pfam01339 272558007525 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272558007526 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 272558007527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272558007528 P-loop; other site 272558007529 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 272558007530 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 272558007531 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 272558007532 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 272558007533 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 272558007534 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 272558007535 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272558007536 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 272558007537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558007538 active site 272558007539 phosphorylation site [posttranslational modification] 272558007540 intermolecular recognition site; other site 272558007541 dimerization interface [polypeptide binding]; other site 272558007542 flagellar motor switch protein; Validated; Region: PRK08119 272558007543 CheC-like family; Region: CheC; pfam04509 272558007544 CheC-like family; Region: CheC; pfam04509 272558007545 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 272558007546 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 272558007547 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272558007548 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 272558007549 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 272558007550 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 272558007551 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272558007552 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272558007553 flagellar operon protein; Region: flg_new; TIGR02530 272558007554 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 272558007555 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272558007556 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 272558007557 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272558007558 Uncharacterized conserved protein [Function unknown]; Region: COG3334 272558007559 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 272558007560 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 272558007561 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272558007562 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 272558007563 Walker A motif/ATP binding site; other site 272558007564 Walker B motif; other site 272558007565 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 272558007566 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272558007567 Flagellar assembly protein FliH; Region: FliH; cl19405 272558007568 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272558007569 FliG N-terminal domain; Region: FliG_N; pfam14842 272558007570 FliG middle domain; Region: FliG_M; pfam14841 272558007571 FliG C-terminal domain; Region: FliG_C; pfam01706 272558007572 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 272558007573 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 272558007574 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272558007575 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 272558007576 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 272558007577 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272558007578 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272558007579 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272558007580 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 272558007581 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272558007582 transcriptional repressor CodY; Validated; Region: PRK04158 272558007583 CodY GAF-like domain; Region: CodY; pfam06018 272558007584 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 272558007585 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272558007586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558007587 Walker A motif; other site 272558007588 ATP binding site [chemical binding]; other site 272558007589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558007590 Walker B motif; other site 272558007591 arginine finger; other site 272558007592 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272558007593 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272558007594 active site 272558007595 HslU subunit interaction site [polypeptide binding]; other site 272558007596 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272558007597 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272558007598 active site 272558007599 Int/Topo IB signature motif; other site 272558007600 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272558007601 Glucose inhibited division protein A; Region: GIDA; pfam01134 272558007602 DNA topoisomerase I; Validated; Region: PRK05582 272558007603 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272558007604 active site 272558007605 interdomain interaction site; other site 272558007606 putative metal-binding site [ion binding]; other site 272558007607 nucleotide binding site [chemical binding]; other site 272558007608 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272558007609 domain I; other site 272558007610 DNA binding groove [nucleotide binding] 272558007611 phosphate binding site [ion binding]; other site 272558007612 domain II; other site 272558007613 domain III; other site 272558007614 nucleotide binding site [chemical binding]; other site 272558007615 catalytic site [active] 272558007616 domain IV; other site 272558007617 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272558007618 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272558007619 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 272558007620 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272558007621 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272558007622 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272558007623 CoA binding domain; Region: CoA_binding; smart00881 272558007624 CoA-ligase; Region: Ligase_CoA; pfam00549 272558007625 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272558007626 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272558007627 CoA-ligase; Region: Ligase_CoA; pfam00549 272558007628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558007629 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558007630 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558007631 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558007632 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272558007633 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272558007634 RNA/DNA hybrid binding site [nucleotide binding]; other site 272558007635 active site 272558007636 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 272558007637 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272558007638 GTP/Mg2+ binding site [chemical binding]; other site 272558007639 G4 box; other site 272558007640 G5 box; other site 272558007641 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272558007642 G1 box; other site 272558007643 G1 box; other site 272558007644 GTP/Mg2+ binding site [chemical binding]; other site 272558007645 Switch I region; other site 272558007646 G2 box; other site 272558007647 G2 box; other site 272558007648 G3 box; other site 272558007649 G3 box; other site 272558007650 Switch II region; other site 272558007651 Switch II region; other site 272558007652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558007653 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558007654 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558007655 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558007656 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272558007657 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272558007658 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272558007659 RimM N-terminal domain; Region: RimM; pfam01782 272558007660 PRC-barrel domain; Region: PRC; pfam05239 272558007661 YlqD protein; Region: YlqD; pfam11068 272558007662 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 272558007663 G-X-X-G motif; other site 272558007664 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272558007665 signal recognition particle protein; Provisional; Region: PRK10867 272558007666 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272558007667 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272558007668 P loop; other site 272558007669 GTP binding site [chemical binding]; other site 272558007670 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272558007671 putative DNA-binding protein; Validated; Region: PRK00118 272558007672 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272558007673 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272558007674 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272558007675 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272558007676 P loop; other site 272558007677 GTP binding site [chemical binding]; other site 272558007678 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272558007679 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272558007680 Walker A/P-loop; other site 272558007681 ATP binding site [chemical binding]; other site 272558007682 Q-loop/lid; other site 272558007683 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 272558007684 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272558007685 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 272558007686 Golgi-localized syntaxin-1-binding clamp; Region: Syntaphilin; pfam15290 272558007687 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272558007688 ABC transporter signature motif; other site 272558007689 Walker B; other site 272558007690 D-loop; other site 272558007691 H-loop/switch region; other site 272558007692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 272558007693 ribonuclease III; Reviewed; Region: rnc; PRK00102 272558007694 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272558007695 dimerization interface [polypeptide binding]; other site 272558007696 active site 272558007697 metal binding site [ion binding]; metal-binding site 272558007698 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272558007699 dsRNA binding site [nucleotide binding]; other site 272558007700 acyl carrier protein; Provisional; Region: acpP; PRK00982 272558007701 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272558007702 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272558007703 NAD(P) binding site [chemical binding]; other site 272558007704 homotetramer interface [polypeptide binding]; other site 272558007705 homodimer interface [polypeptide binding]; other site 272558007706 active site 272558007707 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272558007708 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272558007709 putative phosphate acyltransferase; Provisional; Region: PRK05331 272558007710 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 272558007711 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 272558007712 active site 2 [active] 272558007713 active site 1 [active] 272558007714 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272558007715 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272558007716 generic binding surface II; other site 272558007717 ssDNA binding site; other site 272558007718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558007719 ATP binding site [chemical binding]; other site 272558007720 putative Mg++ binding site [ion binding]; other site 272558007721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558007722 nucleotide binding region [chemical binding]; other site 272558007723 ATP-binding site [chemical binding]; other site 272558007724 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272558007725 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272558007726 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 272558007727 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272558007728 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 272558007729 putative L-serine binding site [chemical binding]; other site 272558007730 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272558007731 DAK2 domain; Region: Dak2; pfam02734 272558007732 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 272558007733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272558007734 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272558007735 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 272558007736 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272558007737 substrate binding site [chemical binding]; other site 272558007738 hexamer interface [polypeptide binding]; other site 272558007739 metal binding site [ion binding]; metal-binding site 272558007740 GTPase RsgA; Reviewed; Region: PRK00098 272558007741 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272558007742 RNA binding site [nucleotide binding]; other site 272558007743 homodimer interface [polypeptide binding]; other site 272558007744 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272558007745 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272558007746 GTP/Mg2+ binding site [chemical binding]; other site 272558007747 G4 box; other site 272558007748 G5 box; other site 272558007749 G1 box; other site 272558007750 Switch I region; other site 272558007751 G2 box; other site 272558007752 G3 box; other site 272558007753 Switch II region; other site 272558007754 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272558007755 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272558007756 active site 272558007757 ATP binding site [chemical binding]; other site 272558007758 substrate binding site [chemical binding]; other site 272558007759 activation loop (A-loop); other site 272558007760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 272558007761 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272558007762 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272558007763 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272558007764 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272558007765 active site 272558007766 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 272558007767 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 272558007768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558007769 FeS/SAM binding site; other site 272558007770 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272558007771 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 272558007772 putative RNA binding site [nucleotide binding]; other site 272558007773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558007774 S-adenosylmethionine binding site [chemical binding]; other site 272558007775 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272558007776 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272558007777 putative active site [active] 272558007778 substrate binding site [chemical binding]; other site 272558007779 putative cosubstrate binding site; other site 272558007780 catalytic site [active] 272558007781 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272558007782 substrate binding site [chemical binding]; other site 272558007783 primosome assembly protein PriA; Validated; Region: PRK05580 272558007784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558007785 ATP binding site [chemical binding]; other site 272558007786 putative Mg++ binding site [ion binding]; other site 272558007787 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272558007788 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272558007789 Flavoprotein; Region: Flavoprotein; cl19190 272558007790 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 272558007791 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272558007792 Guanylate kinase; Region: Guanylate_kin; pfam00625 272558007793 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272558007794 catalytic site [active] 272558007795 G-X2-G-X-G-K; other site 272558007796 hypothetical protein; Provisional; Region: PRK04323 272558007797 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 272558007798 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272558007799 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272558007800 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272558007801 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272558007802 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272558007803 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272558007804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558007805 motif II; other site 272558007806 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272558007807 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 272558007808 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272558007809 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272558007810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 272558007811 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 272558007812 Winged helix-turn helix; Region: HTH_33; pfam13592 272558007813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 272558007814 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558007815 LXG domain of WXG superfamily; Region: LXG; pfam04740 272558007816 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272558007817 Helix-turn-helix domain; Region: HTH_38; pfam13936 272558007818 Homeodomain-like domain; Region: HTH_32; pfam13565 272558007819 Integrase core domain; Region: rve; pfam00665 272558007820 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 272558007821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558007822 FeS/SAM binding site; other site 272558007823 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272558007824 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 272558007825 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 272558007826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558007827 putative substrate translocation pore; other site 272558007828 Uncharacterized conserved protein [Function unknown]; Region: COG5609 272558007829 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272558007830 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 272558007831 putative molybdopterin cofactor binding site [chemical binding]; other site 272558007832 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 272558007833 putative molybdopterin cofactor binding site; other site 272558007834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558007835 S-adenosylmethionine binding site [chemical binding]; other site 272558007836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558007837 active site 272558007838 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272558007839 active site 272558007840 dimer interface [polypeptide binding]; other site 272558007841 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272558007842 heterodimer interface [polypeptide binding]; other site 272558007843 active site 272558007844 FMN binding site [chemical binding]; other site 272558007845 homodimer interface [polypeptide binding]; other site 272558007846 substrate binding site [chemical binding]; other site 272558007847 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272558007848 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272558007849 FAD binding pocket [chemical binding]; other site 272558007850 FAD binding motif [chemical binding]; other site 272558007851 phosphate binding motif [ion binding]; other site 272558007852 beta-alpha-beta structure motif; other site 272558007853 NAD binding pocket [chemical binding]; other site 272558007854 Iron coordination center [ion binding]; other site 272558007855 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272558007856 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558007857 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272558007858 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 272558007859 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558007860 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558007861 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272558007862 IMP binding site; other site 272558007863 dimer interface [polypeptide binding]; other site 272558007864 interdomain contacts; other site 272558007865 partial ornithine binding site; other site 272558007866 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272558007867 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272558007868 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272558007869 catalytic site [active] 272558007870 subunit interface [polypeptide binding]; other site 272558007871 dihydroorotase; Validated; Region: pyrC; PRK09357 272558007872 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558007873 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272558007874 active site 272558007875 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272558007876 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272558007877 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272558007878 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 272558007879 Sulfate transporter family; Region: Sulfate_transp; cl19250 272558007880 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558007881 active site 272558007882 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272558007883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558007884 RNA binding surface [nucleotide binding]; other site 272558007885 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272558007886 active site 272558007887 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 272558007888 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 272558007889 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272558007890 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272558007891 active site 272558007892 HIGH motif; other site 272558007893 KMSKS motif; other site 272558007894 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272558007895 tRNA binding surface [nucleotide binding]; other site 272558007896 anticodon binding site; other site 272558007897 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272558007898 DivIVA protein; Region: DivIVA; pfam05103 272558007899 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272558007900 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 272558007901 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558007902 RNA binding surface [nucleotide binding]; other site 272558007903 YGGT family; Region: YGGT; pfam02325 272558007904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272558007905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272558007906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272558007907 catalytic residue [active] 272558007908 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272558007909 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 272558007910 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 272558007911 sporulation sigma factor SigG; Reviewed; Region: PRK08215 272558007912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558007913 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272558007914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558007915 DNA binding residues [nucleotide binding] 272558007916 sporulation sigma factor SigE; Reviewed; Region: PRK08301 272558007917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558007918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558007919 DNA binding residues [nucleotide binding] 272558007920 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 272558007921 cell division protein FtsZ; Validated; Region: PRK09330 272558007922 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272558007923 nucleotide binding site [chemical binding]; other site 272558007924 SulA interaction site; other site 272558007925 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272558007926 Cell division protein FtsA; Region: FtsA; smart00842 272558007927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558007928 nucleotide binding site [chemical binding]; other site 272558007929 Cell division protein FtsA; Region: FtsA; pfam14450 272558007930 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 272558007931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 272558007932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 272558007933 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272558007934 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272558007935 Cell division protein FtsQ; Region: FtsQ; pfam03799 272558007936 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272558007937 FAD binding domain; Region: FAD_binding_4; pfam01565 272558007938 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272558007939 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272558007940 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272558007941 active site 272558007942 homodimer interface [polypeptide binding]; other site 272558007943 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272558007944 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 272558007945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272558007946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272558007947 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272558007948 Mg++ binding site [ion binding]; other site 272558007949 putative catalytic motif [active] 272558007950 putative substrate binding site [chemical binding]; other site 272558007951 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 272558007952 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272558007953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272558007954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272558007955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272558007956 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272558007957 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272558007958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272558007959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272558007960 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 272558007961 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272558007962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558007963 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 272558007964 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272558007965 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272558007966 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558007967 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272558007968 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272558007969 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 272558007970 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272558007971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 272558007972 MraZ protein; Region: MraZ; pfam02381 272558007973 MraZ protein; Region: MraZ; pfam02381 272558007974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 272558007975 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 272558007976 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272558007977 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 272558007978 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272558007979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558007980 Coenzyme A binding pocket [chemical binding]; other site 272558007981 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 272558007982 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272558007983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558007984 substrate binding site [chemical binding]; other site 272558007985 oxyanion hole (OAH) forming residues; other site 272558007986 trimer interface [polypeptide binding]; other site 272558007987 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272558007988 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 272558007989 hypothetical protein; Provisional; Region: PRK13670 272558007990 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 272558007991 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272558007992 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 272558007993 protein binding site [polypeptide binding]; other site 272558007994 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272558007995 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272558007996 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272558007997 active site 272558007998 nucleophile elbow; other site 272558007999 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 272558008000 Nucleoside recognition; Region: Gate; pfam07670 272558008001 Nucleoside recognition; Region: Gate; pfam07670 272558008002 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272558008003 active site 272558008004 (T/H)XGH motif; other site 272558008005 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558008006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558008007 S-adenosylmethionine binding site [chemical binding]; other site 272558008008 drug efflux system protein MdtG; Provisional; Region: PRK09874 272558008009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558008010 putative substrate translocation pore; other site 272558008011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 272558008012 hypothetical protein; Provisional; Region: PRK02886 272558008013 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 272558008014 UV damage repair endonuclease [DNA replication, recombination, and repair]; Region: Uve; COG4294 272558008015 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 272558008016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558008017 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 272558008018 YlbE-like protein; Region: YlbE; pfam14003 272558008019 Putative coat protein; Region: YlbD_coat; pfam14071 272558008020 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272558008021 CoenzymeA binding site [chemical binding]; other site 272558008022 subunit interaction site [polypeptide binding]; other site 272558008023 PHB binding site; other site 272558008024 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272558008025 homodimer interface [polypeptide binding]; other site 272558008026 substrate-cofactor binding pocket; other site 272558008027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008028 catalytic residue [active] 272558008029 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 272558008030 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272558008031 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272558008032 FOG: CBS domain [General function prediction only]; Region: COG0517 272558008033 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 272558008034 YugN-like family; Region: YugN; pfam08868 272558008035 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 272558008036 Oxidoreductase NAD-binding domain; Region: NAD_binding_1; pfam00175 272558008037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558008038 Coenzyme A binding pocket [chemical binding]; other site 272558008039 Predicted membrane protein [Function unknown]; Region: COG2322 272558008040 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 272558008041 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 272558008042 Subunit I/III interface [polypeptide binding]; other site 272558008043 Subunit III/IV interface [polypeptide binding]; other site 272558008044 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272558008045 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272558008046 D-pathway; other site 272558008047 Putative ubiquinol binding site [chemical binding]; other site 272558008048 Low-spin heme (heme b) binding site [chemical binding]; other site 272558008049 Putative water exit pathway; other site 272558008050 Binuclear center (heme o3/CuB) [ion binding]; other site 272558008051 K-pathway; other site 272558008052 Putative proton exit pathway; other site 272558008053 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 272558008054 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272558008055 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 272558008056 oligomer interface [polypeptide binding]; other site 272558008057 CuA binuclear center [ion binding]; other site 272558008058 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 272558008059 Cytochrome c; Region: Cytochrom_C; pfam00034 272558008060 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 272558008061 putative active site [active] 272558008062 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272558008063 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 272558008064 IucA / IucC family; Region: IucA_IucC; pfam04183 272558008065 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272558008066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558008067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558008068 putative substrate translocation pore; other site 272558008069 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 272558008070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558008071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272558008072 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 272558008073 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 272558008074 IucA / IucC family; Region: IucA_IucC; pfam04183 272558008075 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272558008076 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 272558008077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008078 catalytic residue [active] 272558008079 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558008080 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558008081 inhibitor-cofactor binding pocket; inhibition site 272558008082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008083 catalytic residue [active] 272558008084 pyruvate carboxylase; Reviewed; Region: PRK12999 272558008085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558008086 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272558008087 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272558008088 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272558008089 active site 272558008090 catalytic residues [active] 272558008091 metal binding site [ion binding]; metal-binding site 272558008092 homodimer binding site [polypeptide binding]; other site 272558008093 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 272558008094 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272558008095 carboxyltransferase (CT) interaction site; other site 272558008096 biotinylation site [posttranslational modification]; other site 272558008097 hypothetical protein; Provisional; Region: PRK13666 272558008098 glutaminase A; Region: Gln_ase; TIGR03814 272558008099 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272558008100 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 272558008101 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 272558008102 putative active site [active] 272558008103 PhoH-like protein; Region: PhoH; pfam02562 272558008104 hypothetical protein; Provisional; Region: PRK06733 272558008105 YlaH-like protein; Region: YlaH; pfam14036 272558008106 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272558008107 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272558008108 G1 box; other site 272558008109 putative GEF interaction site [polypeptide binding]; other site 272558008110 GTP/Mg2+ binding site [chemical binding]; other site 272558008111 Switch I region; other site 272558008112 G2 box; other site 272558008113 G3 box; other site 272558008114 Switch II region; other site 272558008115 G4 box; other site 272558008116 G5 box; other site 272558008117 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272558008118 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272558008119 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272558008120 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272558008121 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272558008122 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 272558008123 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 272558008124 active site 272558008125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 272558008126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 272558008127 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272558008128 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272558008129 FMN binding site [chemical binding]; other site 272558008130 substrate binding site [chemical binding]; other site 272558008131 putative catalytic residue [active] 272558008132 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272558008133 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272558008134 homodimer interface [polypeptide binding]; other site 272558008135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008136 catalytic residue [active] 272558008137 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272558008138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558008139 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558008140 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558008141 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558008142 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272558008143 Peptidase family M23; Region: Peptidase_M23; pfam01551 272558008144 Predicted membrane protein [Function unknown]; Region: COG4129 272558008145 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272558008146 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 272558008147 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272558008148 Predicted transcriptional regulators [Transcription]; Region: COG1725 272558008149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558008150 DNA-binding site [nucleotide binding]; DNA binding site 272558008151 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558008152 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558008153 Walker A/P-loop; other site 272558008154 ATP binding site [chemical binding]; other site 272558008155 Q-loop/lid; other site 272558008156 ABC transporter signature motif; other site 272558008157 Walker B; other site 272558008158 D-loop; other site 272558008159 H-loop/switch region; other site 272558008160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558008161 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558008162 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558008163 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558008164 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272558008165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558008166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558008167 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272558008168 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272558008169 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272558008170 E3 interaction surface; other site 272558008171 lipoyl attachment site [posttranslational modification]; other site 272558008172 e3 binding domain; Region: E3_binding; pfam02817 272558008173 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558008174 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272558008175 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272558008176 alpha subunit interface [polypeptide binding]; other site 272558008177 TPP binding site [chemical binding]; other site 272558008178 heterodimer interface [polypeptide binding]; other site 272558008179 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558008180 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272558008181 TPP-binding site [chemical binding]; other site 272558008182 heterodimer interface [polypeptide binding]; other site 272558008183 tetramer interface [polypeptide binding]; other site 272558008184 phosphorylation loop region [posttranslational modification] 272558008185 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 272558008186 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 272558008187 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272558008188 active site 272558008189 catalytic residues [active] 272558008190 metal binding site [ion binding]; metal-binding site 272558008191 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272558008192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558008193 active site 272558008194 motif I; other site 272558008195 motif II; other site 272558008196 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558008197 Uncharacterized conserved small protein [Function unknown]; Region: COG5503 272558008198 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272558008199 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272558008200 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272558008201 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272558008202 TrkA-N domain; Region: TrkA_N; pfam02254 272558008203 TrkA-C domain; Region: TrkA_C; pfam02080 272558008204 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272558008205 catalytic residues [active] 272558008206 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272558008207 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272558008208 dimer interface [polypeptide binding]; other site 272558008209 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272558008210 catalytic triad [active] 272558008211 peroxidatic and resolving cysteines [active] 272558008212 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272558008213 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272558008214 hypothetical protein; Provisional; Region: PRK03094 272558008215 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272558008216 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 272558008217 metal binding site [ion binding]; metal-binding site 272558008218 putative dimer interface [polypeptide binding]; other site 272558008219 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 272558008220 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272558008221 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272558008222 trimer interface [polypeptide binding]; other site 272558008223 active site 272558008224 substrate binding site [chemical binding]; other site 272558008225 CoA binding site [chemical binding]; other site 272558008226 Predicted permeases [General function prediction only]; Region: COG0679 272558008227 DctM-like transporters; Region: DctM; pfam06808 272558008228 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272558008229 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272558008230 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272558008231 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272558008232 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272558008233 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272558008234 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272558008235 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272558008236 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272558008237 putative active site [active] 272558008238 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 272558008239 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 272558008240 N- and C-terminal domain interface [polypeptide binding]; other site 272558008241 active site 272558008242 catalytic site [active] 272558008243 metal binding site [ion binding]; metal-binding site 272558008244 carbohydrate binding site [chemical binding]; other site 272558008245 ATP binding site [chemical binding]; other site 272558008246 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272558008247 tetramer interface [polypeptide binding]; other site 272558008248 active site 272558008249 Mg2+/Mn2+ binding site [ion binding]; other site 272558008250 acetylornithine deacetylase; Validated; Region: PRK08596 272558008251 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 272558008252 metal binding site [ion binding]; metal-binding site 272558008253 Putative transcription activator [Transcription]; Region: TenA; COG0819 272558008254 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272558008255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558008256 Walker A/P-loop; other site 272558008257 ATP binding site [chemical binding]; other site 272558008258 Q-loop/lid; other site 272558008259 ABC transporter signature motif; other site 272558008260 Walker B; other site 272558008261 D-loop; other site 272558008262 H-loop/switch region; other site 272558008263 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272558008264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558008265 dimer interface [polypeptide binding]; other site 272558008266 conserved gate region; other site 272558008267 putative PBP binding loops; other site 272558008268 ABC-ATPase subunit interface; other site 272558008269 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272558008270 NMT1/THI5 like; Region: NMT1; pfam09084 272558008271 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272558008272 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272558008273 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272558008274 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 272558008275 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272558008276 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272558008277 active site 272558008278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558008279 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 272558008280 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 272558008281 hypothetical protein; Provisional; Region: PRK08236 272558008282 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272558008283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558008284 active site 272558008285 motif I; other site 272558008286 motif II; other site 272558008287 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558008288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558008289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558008290 putative substrate translocation pore; other site 272558008291 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272558008292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558008293 DNA-binding site [nucleotide binding]; DNA binding site 272558008294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558008295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008296 homodimer interface [polypeptide binding]; other site 272558008297 catalytic residue [active] 272558008298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558008299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558008300 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558008301 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272558008302 FtsX-like permease family; Region: FtsX; pfam02687 272558008303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558008304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558008305 Walker A/P-loop; other site 272558008306 ATP binding site [chemical binding]; other site 272558008307 Q-loop/lid; other site 272558008308 ABC transporter signature motif; other site 272558008309 Walker B; other site 272558008310 D-loop; other site 272558008311 H-loop/switch region; other site 272558008312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558008313 RDD family; Region: RDD; cl00746 272558008314 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 272558008315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558008316 Mg2+ binding site [ion binding]; other site 272558008317 G-X-G motif; other site 272558008318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558008319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558008320 active site 272558008321 phosphorylation site [posttranslational modification] 272558008322 intermolecular recognition site; other site 272558008323 dimerization interface [polypeptide binding]; other site 272558008324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558008325 DNA binding site [nucleotide binding] 272558008326 heat shock protein HtpX; Provisional; Region: PRK05457 272558008327 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558008328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558008329 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558008330 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 272558008331 Na binding site [ion binding]; other site 272558008332 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272558008333 active site 272558008334 ATP binding site [chemical binding]; other site 272558008335 Uncharacterized conserved protein [Function unknown]; Region: COG3937 272558008336 FOG: CBS domain [General function prediction only]; Region: COG0517 272558008337 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272558008338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558008339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272558008340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272558008341 dimerization interface [polypeptide binding]; other site 272558008342 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272558008343 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 272558008344 hinge; other site 272558008345 active site 272558008346 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272558008347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558008348 active site 272558008349 phosphorylation site [posttranslational modification] 272558008350 intermolecular recognition site; other site 272558008351 dimerization interface [polypeptide binding]; other site 272558008352 YcbB domain; Region: YcbB; pfam08664 272558008353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558008354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558008355 ATP binding site [chemical binding]; other site 272558008356 Mg2+ binding site [ion binding]; other site 272558008357 G-X-G motif; other site 272558008358 glutaminase; Reviewed; Region: PRK12357 272558008359 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272558008360 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558008361 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272558008362 NAD(P) binding site [chemical binding]; other site 272558008363 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272558008364 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558008365 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 272558008366 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 272558008367 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272558008368 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272558008369 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 272558008370 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 272558008371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558008372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558008373 dimer interface [polypeptide binding]; other site 272558008374 conserved gate region; other site 272558008375 putative PBP binding loops; other site 272558008376 ABC-ATPase subunit interface; other site 272558008377 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272558008378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558008379 dimer interface [polypeptide binding]; other site 272558008380 conserved gate region; other site 272558008381 putative PBP binding loops; other site 272558008382 ABC-ATPase subunit interface; other site 272558008383 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558008384 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272558008385 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558008386 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558008387 dimerization interface [polypeptide binding]; other site 272558008388 Histidine kinase; Region: His_kinase; pfam06580 272558008389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558008390 ATP binding site [chemical binding]; other site 272558008391 Mg2+ binding site [ion binding]; other site 272558008392 G-X-G motif; other site 272558008393 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272558008394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558008395 active site 272558008396 phosphorylation site [posttranslational modification] 272558008397 intermolecular recognition site; other site 272558008398 dimerization interface [polypeptide binding]; other site 272558008399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558008400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558008401 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272558008402 Cysteine-rich domain; Region: CCG; pfam02754 272558008403 Cysteine-rich domain; Region: CCG; pfam02754 272558008404 FAD binding domain; Region: FAD_binding_4; pfam01565 272558008405 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 272558008406 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272558008407 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 272558008408 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 272558008409 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272558008410 metal binding site [ion binding]; metal-binding site 272558008411 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272558008412 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558008413 Phosphotransferase enzyme family; Region: APH; pfam01636 272558008414 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272558008415 active site 272558008416 substrate binding site [chemical binding]; other site 272558008417 ATP binding site [chemical binding]; other site 272558008418 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272558008419 active site 272558008420 ATP binding site [chemical binding]; other site 272558008421 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272558008422 substrate binding site [chemical binding]; other site 272558008423 activation loop (A-loop); other site 272558008424 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 272558008425 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 272558008426 Glutamate binding site [chemical binding]; other site 272558008427 homodimer interface [polypeptide binding]; other site 272558008428 NAD binding site [chemical binding]; other site 272558008429 catalytic residues [active] 272558008430 Bacterial PH domain; Region: bPH_4; pfam06713 272558008431 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 272558008432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558008433 putative active site [active] 272558008434 heme pocket [chemical binding]; other site 272558008435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558008436 Walker A motif; other site 272558008437 ATP binding site [chemical binding]; other site 272558008438 Walker B motif; other site 272558008439 arginine finger; other site 272558008440 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558008441 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 272558008442 Proline dehydrogenase; Region: Pro_dh; pfam01619 272558008443 DNA polymerase IV; Reviewed; Region: PRK03103 272558008444 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272558008445 active site 272558008446 DNA binding site [nucleotide binding] 272558008447 YolD-like protein; Region: YolD; pfam08863 272558008448 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 272558008449 nucleotide binding site/active site [active] 272558008450 HIT family signature motif; other site 272558008451 catalytic residue [active] 272558008452 Uncharacterized conserved protein [Function unknown]; Region: COG1742 272558008453 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 272558008454 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558008455 EamA-like transporter family; Region: EamA; pfam00892 272558008456 EamA-like transporter family; Region: EamA; pfam00892 272558008457 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272558008458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558008459 putative substrate translocation pore; other site 272558008460 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558008461 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 272558008462 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 272558008463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558008464 active site 272558008465 phosphorylation site [posttranslational modification] 272558008466 intermolecular recognition site; other site 272558008467 dimerization interface [polypeptide binding]; other site 272558008468 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 272558008469 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 272558008470 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 272558008471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558008472 putative active site [active] 272558008473 heme pocket [chemical binding]; other site 272558008474 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 272558008475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558008476 ATP binding site [chemical binding]; other site 272558008477 Mg2+ binding site [ion binding]; other site 272558008478 G-X-G motif; other site 272558008479 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558008480 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 272558008481 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272558008482 active site 272558008483 catalytic residues [active] 272558008484 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272558008485 N- and C-terminal domain interface [polypeptide binding]; other site 272558008486 D-xylulose kinase; Region: XylB; TIGR01312 272558008487 active site 272558008488 MgATP binding site [chemical binding]; other site 272558008489 catalytic site [active] 272558008490 metal binding site [ion binding]; metal-binding site 272558008491 xylulose binding site [chemical binding]; other site 272558008492 homodimer interface [polypeptide binding]; other site 272558008493 xylose isomerase; Provisional; Region: PRK05474 272558008494 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272558008495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558008496 nucleotide binding site [chemical binding]; other site 272558008497 Disulphide isomerase; Region: Disulph_isomer; pfam06491 272558008498 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272558008499 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272558008500 intersubunit interface [polypeptide binding]; other site 272558008501 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272558008502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272558008503 E3 interaction surface; other site 272558008504 lipoyl attachment site [posttranslational modification]; other site 272558008505 e3 binding domain; Region: E3_binding; pfam02817 272558008506 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272558008507 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272558008508 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272558008509 alpha subunit interface [polypeptide binding]; other site 272558008510 TPP binding site [chemical binding]; other site 272558008511 heterodimer interface [polypeptide binding]; other site 272558008512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558008513 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272558008514 tetramer interface [polypeptide binding]; other site 272558008515 TPP-binding site [chemical binding]; other site 272558008516 heterodimer interface [polypeptide binding]; other site 272558008517 phosphorylation loop region [posttranslational modification] 272558008518 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 272558008519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558008520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558008521 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272558008522 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272558008523 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558008524 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 272558008525 NAD binding site [chemical binding]; other site 272558008526 Phe binding site; other site 272558008527 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 272558008528 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 272558008529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558008530 putative active site [active] 272558008531 heme pocket [chemical binding]; other site 272558008532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558008533 putative active site [active] 272558008534 heme pocket [chemical binding]; other site 272558008535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558008536 Walker A motif; other site 272558008537 ATP binding site [chemical binding]; other site 272558008538 Walker B motif; other site 272558008539 arginine finger; other site 272558008540 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558008541 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 272558008542 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272558008543 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272558008544 Ligand binding site; other site 272558008545 Putative Catalytic site; other site 272558008546 DXD motif; other site 272558008547 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 272558008548 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 272558008549 Thiamine pyrophosphokinase; Region: TPK; cd07995 272558008550 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 272558008551 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 272558008552 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 272558008553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558008554 active site 272558008555 phosphorylation site [posttranslational modification] 272558008556 intermolecular recognition site; other site 272558008557 dimerization interface [polypeptide binding]; other site 272558008558 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 272558008559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558008560 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558008561 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558008562 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558008563 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 272558008564 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272558008565 protein binding site [polypeptide binding]; other site 272558008566 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 272558008567 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272558008568 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272558008569 Walker A/P-loop; other site 272558008570 ATP binding site [chemical binding]; other site 272558008571 Q-loop/lid; other site 272558008572 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272558008573 ABC transporter signature motif; other site 272558008574 Walker B; other site 272558008575 D-loop; other site 272558008576 H-loop/switch region; other site 272558008577 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272558008578 arginine repressor; Provisional; Region: PRK04280 272558008579 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272558008580 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272558008581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558008582 RNA binding surface [nucleotide binding]; other site 272558008583 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272558008584 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 272558008585 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272558008586 TPP-binding site; other site 272558008587 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272558008588 PYR/PP interface [polypeptide binding]; other site 272558008589 dimer interface [polypeptide binding]; other site 272558008590 TPP binding site [chemical binding]; other site 272558008591 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272558008592 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272558008593 substrate binding pocket [chemical binding]; other site 272558008594 chain length determination region; other site 272558008595 active site lid residues [active] 272558008596 substrate-Mg2+ binding site; other site 272558008597 catalytic residues [active] 272558008598 aspartate-rich region 1; other site 272558008599 aspartate-rich region 2; other site 272558008600 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 272558008601 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272558008602 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272558008603 generic binding surface II; other site 272558008604 generic binding surface I; other site 272558008605 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 272558008606 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272558008607 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272558008608 homodimer interface [polypeptide binding]; other site 272558008609 NADP binding site [chemical binding]; other site 272558008610 substrate binding site [chemical binding]; other site 272558008611 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272558008612 putative RNA binding site [nucleotide binding]; other site 272558008613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272558008614 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272558008615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558008616 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272558008617 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272558008618 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272558008619 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272558008620 carboxyltransferase (CT) interaction site; other site 272558008621 biotinylation site [posttranslational modification]; other site 272558008622 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 272558008623 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 272558008624 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 272558008625 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 272558008626 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 272558008627 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 272558008628 stage III sporulation protein AB; Region: spore_III_AB; TIGR02833 272558008629 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 272558008630 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272558008631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558008632 Walker A motif; other site 272558008633 ATP binding site [chemical binding]; other site 272558008634 Walker B motif; other site 272558008635 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 272558008636 elongation factor P; Validated; Region: PRK00529 272558008637 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272558008638 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272558008639 RNA binding site [nucleotide binding]; other site 272558008640 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272558008641 RNA binding site [nucleotide binding]; other site 272558008642 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272558008643 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272558008644 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272558008645 active site 272558008646 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272558008647 trimer interface [polypeptide binding]; other site 272558008648 active site 272558008649 dimer interface [polypeptide binding]; other site 272558008650 Conserved membrane protein YqhR; Region: YqhR; pfam11085 272558008651 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 272558008652 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 272558008653 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272558008654 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272558008655 active site 272558008656 nucleophile elbow; other site 272558008657 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558008658 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272558008659 manganese transport transcriptional regulator; Provisional; Region: PRK03902 272558008660 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272558008661 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 272558008662 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272558008663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558008664 FeS/SAM binding site; other site 272558008665 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 272558008666 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 272558008667 active site 272558008668 dimer interface [polypeptide binding]; other site 272558008669 effector binding site; other site 272558008670 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272558008671 homodimer interface [polypeptide binding]; other site 272558008672 substrate-cofactor binding pocket; other site 272558008673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008674 catalytic residue [active] 272558008675 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272558008676 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272558008677 active site residue [active] 272558008678 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272558008679 tetramer interface [polypeptide binding]; other site 272558008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008681 catalytic residue [active] 272558008682 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272558008683 tetramer interface [polypeptide binding]; other site 272558008684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008685 catalytic residue [active] 272558008686 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 272558008687 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 272558008688 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272558008689 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272558008690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558008691 ATP binding site [chemical binding]; other site 272558008692 putative Mg++ binding site [ion binding]; other site 272558008693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558008694 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272558008695 nucleotide binding region [chemical binding]; other site 272558008696 ATP-binding site [chemical binding]; other site 272558008697 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 272558008698 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 272558008699 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272558008700 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 272558008701 YqzE-like protein; Region: YqzE; pfam14038 272558008702 ComG operon protein 7; Region: ComGG; pfam14173 272558008703 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 272558008704 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272558008705 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272558008706 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 272558008707 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 272558008708 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272558008709 hypothetical protein; Validated; Region: PRK00041 272558008710 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272558008711 catalytic residues [active] 272558008712 dimer interface [polypeptide binding]; other site 272558008713 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272558008714 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272558008715 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272558008716 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272558008717 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272558008718 Walker A motif; other site 272558008719 ATP binding site [chemical binding]; other site 272558008720 Walker B motif; other site 272558008721 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272558008722 Part of AAA domain; Region: AAA_19; pfam13245 272558008723 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272558008724 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272558008725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558008726 Zn2+ binding site [ion binding]; other site 272558008727 Mg2+ binding site [ion binding]; other site 272558008728 Autophagy protein Apg6; Region: APG6; pfam04111 272558008729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272558008730 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 272558008731 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272558008732 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 272558008733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558008734 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 272558008735 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558008736 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558008737 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558008738 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272558008739 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272558008740 NAD binding site [chemical binding]; other site 272558008741 homotetramer interface [polypeptide binding]; other site 272558008742 homodimer interface [polypeptide binding]; other site 272558008743 substrate binding site [chemical binding]; other site 272558008744 active site 272558008745 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272558008746 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 272558008747 Ligand Binding Site [chemical binding]; other site 272558008748 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 272558008749 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 272558008750 active site 272558008751 metal binding site [ion binding]; metal-binding site 272558008752 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 272558008753 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272558008754 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272558008755 active site 272558008756 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 272558008757 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272558008758 synthetase active site [active] 272558008759 NTP binding site [chemical binding]; other site 272558008760 metal binding site [ion binding]; metal-binding site 272558008761 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 272558008762 putative active site [active] 272558008763 putative metal binding residues [ion binding]; other site 272558008764 signature motif; other site 272558008765 putative triphosphate binding site [ion binding]; other site 272558008766 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272558008767 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272558008768 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272558008769 catalytic residue [active] 272558008770 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 272558008771 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 272558008772 putative molybdopterin cofactor binding site [chemical binding]; other site 272558008773 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 272558008774 molybdopterin cofactor binding site; other site 272558008775 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 272558008776 apolar tunnel; other site 272558008777 heme binding site [chemical binding]; other site 272558008778 dimerization interface [polypeptide binding]; other site 272558008779 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 272558008780 catalytic residues [active] 272558008781 oligoendopeptidase F; Region: pepF; TIGR00181 272558008782 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272558008783 active site 272558008784 Zn binding site [ion binding]; other site 272558008785 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 272558008786 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272558008787 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272558008788 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272558008789 putative active site [active] 272558008790 catalytic site [active] 272558008791 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272558008792 putative active site [active] 272558008793 catalytic site [active] 272558008794 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 272558008795 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 272558008796 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272558008797 putative catalytic residues [active] 272558008798 thiol/disulfide switch; other site 272558008799 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272558008800 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272558008801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558008802 Zn2+ binding site [ion binding]; other site 272558008803 Mg2+ binding site [ion binding]; other site 272558008804 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 272558008805 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272558008806 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272558008807 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272558008808 catalytic residues [active] 272558008809 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272558008810 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272558008811 active site 272558008812 HIGH motif; other site 272558008813 dimer interface [polypeptide binding]; other site 272558008814 KMSKS motif; other site 272558008815 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 272558008816 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 272558008817 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272558008818 ATP-binding site [chemical binding]; other site 272558008819 CoA-binding site [chemical binding]; other site 272558008820 Mg2+-binding site [ion binding]; other site 272558008821 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272558008822 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272558008823 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272558008824 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272558008825 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272558008826 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558008827 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 272558008828 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272558008829 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272558008830 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272558008831 active site 272558008832 NTP binding site [chemical binding]; other site 272558008833 metal binding triad [ion binding]; metal-binding site 272558008834 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272558008835 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272558008836 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272558008837 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272558008838 dimer interface [polypeptide binding]; other site 272558008839 active site 272558008840 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272558008841 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272558008842 dimer interface [polypeptide binding]; other site 272558008843 active site 272558008844 CoA binding pocket [chemical binding]; other site 272558008845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558008846 S-adenosylmethionine binding site [chemical binding]; other site 272558008847 ComZ; Region: ComZ; pfam10815 272558008848 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 272558008849 putative ligand binding site [chemical binding]; other site 272558008850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272558008851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558008852 NAD(P) binding site [chemical binding]; other site 272558008853 active site 272558008854 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272558008855 YjzC-like protein; Region: YjzC; pfam14168 272558008856 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272558008857 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272558008858 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272558008859 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 272558008860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558008861 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272558008862 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 272558008863 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272558008864 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558008865 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 272558008866 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272558008867 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272558008868 catalytic site [active] 272558008869 subunit interface [polypeptide binding]; other site 272558008870 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558008871 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558008872 inhibitor-cofactor binding pocket; inhibition site 272558008873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008874 catalytic residue [active] 272558008875 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 272558008876 nucleotide binding site [chemical binding]; other site 272558008877 N-acetyl-L-glutamate binding site [chemical binding]; other site 272558008878 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272558008879 heterotetramer interface [polypeptide binding]; other site 272558008880 active site pocket [active] 272558008881 cleavage site 272558008882 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 272558008883 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272558008884 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272558008885 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272558008886 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272558008887 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272558008888 Ca binding site [ion binding]; other site 272558008889 active site 272558008890 catalytic site [active] 272558008891 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272558008892 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272558008893 Cu(I) binding site [ion binding]; other site 272558008894 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 272558008895 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272558008896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558008897 active site 272558008898 motif I; other site 272558008899 motif II; other site 272558008900 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558008901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558008902 Coenzyme A binding pocket [chemical binding]; other site 272558008903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558008904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558008905 non-specific DNA binding site [nucleotide binding]; other site 272558008906 salt bridge; other site 272558008907 sequence-specific DNA binding site [nucleotide binding]; other site 272558008908 Cupin domain; Region: Cupin_2; pfam07883 272558008909 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 272558008910 Predicted membrane protein [Function unknown]; Region: COG4392 272558008911 SWIM zinc finger; Region: SWIM; pfam04434 272558008912 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272558008913 SNF2 Helicase protein; Region: DUF3670; pfam12419 272558008914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558008915 ATP binding site [chemical binding]; other site 272558008916 putative Mg++ binding site [ion binding]; other site 272558008917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558008918 nucleotide binding region [chemical binding]; other site 272558008919 ATP-binding site [chemical binding]; other site 272558008920 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 272558008921 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272558008922 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558008923 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558008924 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272558008925 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272558008926 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558008927 Domain of unknown function (DUF3941); Region: DUF3941; pfam13081 272558008928 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272558008929 active site residue [active] 272558008930 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272558008931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558008932 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558008933 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558008934 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558008935 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558008936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558008937 DNA binding site [nucleotide binding] 272558008938 domain linker motif; other site 272558008939 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 272558008940 putative dimerization interface [polypeptide binding]; other site 272558008941 putative ligand binding site [chemical binding]; other site 272558008942 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558008943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558008944 dimer interface [polypeptide binding]; other site 272558008945 conserved gate region; other site 272558008946 putative PBP binding loops; other site 272558008947 ABC-ATPase subunit interface; other site 272558008948 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272558008949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558008950 dimer interface [polypeptide binding]; other site 272558008951 conserved gate region; other site 272558008952 putative PBP binding loops; other site 272558008953 ABC-ATPase subunit interface; other site 272558008954 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272558008955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272558008956 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 272558008957 homodimer interface [polypeptide binding]; other site 272558008958 maltodextrin glucosidase; Provisional; Region: PRK10785 272558008959 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272558008960 active site 272558008961 homodimer interface [polypeptide binding]; other site 272558008962 catalytic site [active] 272558008963 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 272558008964 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272558008965 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272558008966 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272558008967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558008968 putative substrate translocation pore; other site 272558008969 LysE type translocator; Region: LysE; cl00565 272558008970 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 272558008971 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 272558008972 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272558008973 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 272558008974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272558008975 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 272558008976 active site 272558008977 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 272558008978 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272558008979 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 272558008980 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272558008981 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 272558008982 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272558008983 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272558008984 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272558008985 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272558008986 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272558008987 putative active site [active] 272558008988 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 272558008989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558008990 inhibitor-cofactor binding pocket; inhibition site 272558008991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558008992 catalytic residue [active] 272558008993 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 272558008994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558008995 FeS/SAM binding site; other site 272558008996 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 272558008997 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272558008998 Uncharacterized conserved protein [Function unknown]; Region: COG4729 272558008999 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272558009000 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272558009001 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272558009002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558009003 active site 272558009004 phosphorylation site [posttranslational modification] 272558009005 intermolecular recognition site; other site 272558009006 dimerization interface [polypeptide binding]; other site 272558009007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558009008 Walker A motif; other site 272558009009 ATP binding site [chemical binding]; other site 272558009010 Walker B motif; other site 272558009011 arginine finger; other site 272558009012 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558009013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272558009014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272558009015 substrate binding pocket [chemical binding]; other site 272558009016 membrane-bound complex binding site; other site 272558009017 hinge residues; other site 272558009018 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272558009019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558009020 putative active site [active] 272558009021 heme pocket [chemical binding]; other site 272558009022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558009023 dimer interface [polypeptide binding]; other site 272558009024 phosphorylation site [posttranslational modification] 272558009025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558009026 ATP binding site [chemical binding]; other site 272558009027 Mg2+ binding site [ion binding]; other site 272558009028 G-X-G motif; other site 272558009029 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 272558009030 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272558009031 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272558009032 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272558009033 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 272558009034 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272558009035 dimer interface [polypeptide binding]; other site 272558009036 FMN binding site [chemical binding]; other site 272558009037 NADPH bind site [chemical binding]; other site 272558009038 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 272558009039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558009040 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 272558009041 Walker A; other site 272558009042 Walker A/P-loop; other site 272558009043 ATP binding site [chemical binding]; other site 272558009044 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272558009045 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 272558009046 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 272558009047 active site 272558009048 substrate binding site [chemical binding]; other site 272558009049 coenzyme B12 binding site [chemical binding]; other site 272558009050 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272558009051 B12 binding site [chemical binding]; other site 272558009052 cobalt ligand [ion binding]; other site 272558009053 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 272558009054 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 272558009055 heterodimer interface [polypeptide binding]; other site 272558009056 substrate interaction site [chemical binding]; other site 272558009057 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 272558009058 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272558009059 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272558009060 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272558009061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558009062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558009063 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 272558009064 IDEAL domain; Region: IDEAL; pfam08858 272558009065 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 272558009066 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272558009067 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558009068 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272558009069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558009070 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558009071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558009072 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558009073 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558009074 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558009075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558009076 active site 272558009077 phosphorylation site [posttranslational modification] 272558009078 intermolecular recognition site; other site 272558009079 dimerization interface [polypeptide binding]; other site 272558009080 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 272558009081 putative CheA interaction surface; other site 272558009082 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272558009083 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272558009084 putative binding surface; other site 272558009085 active site 272558009086 P2 response regulator binding domain; Region: P2; pfam07194 272558009087 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272558009088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558009089 ATP binding site [chemical binding]; other site 272558009090 Mg2+ binding site [ion binding]; other site 272558009091 G-X-G motif; other site 272558009092 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272558009093 PAS domain; Region: PAS_9; pfam13426 272558009094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272558009095 metal binding site [ion binding]; metal-binding site 272558009096 active site 272558009097 I-site; other site 272558009098 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272558009099 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272558009100 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272558009101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558009102 motif II; other site 272558009103 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272558009104 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 272558009105 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272558009106 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272558009107 Walker A/P-loop; other site 272558009108 ATP binding site [chemical binding]; other site 272558009109 Q-loop/lid; other site 272558009110 ABC transporter signature motif; other site 272558009111 Walker B; other site 272558009112 D-loop; other site 272558009113 H-loop/switch region; other site 272558009114 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272558009115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558009116 dimer interface [polypeptide binding]; other site 272558009117 conserved gate region; other site 272558009118 putative PBP binding loops; other site 272558009119 ABC-ATPase subunit interface; other site 272558009120 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272558009121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558009122 dimer interface [polypeptide binding]; other site 272558009123 conserved gate region; other site 272558009124 putative PBP binding loops; other site 272558009125 ABC-ATPase subunit interface; other site 272558009126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558009127 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558009128 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558009129 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558009130 Variant SH3 domain; Region: SH3_2; pfam07653 272558009131 peptide ligand binding site [polypeptide binding]; other site 272558009132 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 272558009133 AAA ATPase domain; Region: AAA_16; pfam13191 272558009134 Part of AAA domain; Region: AAA_19; pfam13245 272558009135 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272558009136 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272558009137 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 272558009138 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272558009139 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558009140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558009141 Coenzyme A binding pocket [chemical binding]; other site 272558009142 hypothetical protein; Provisional; Region: PRK13673 272558009143 Arginase family; Region: Arginase; cd09989 272558009144 active site 272558009145 Mn binding site [ion binding]; other site 272558009146 oligomer interface [polypeptide binding]; other site 272558009147 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 272558009148 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 272558009149 YusW-like protein; Region: YusW; pfam14039 272558009150 YusW-like protein; Region: YusW; pfam14039 272558009151 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272558009152 PhoU domain; Region: PhoU; pfam01895 272558009153 PhoU domain; Region: PhoU; pfam01895 272558009154 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 272558009155 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272558009156 Walker A/P-loop; other site 272558009157 ATP binding site [chemical binding]; other site 272558009158 Q-loop/lid; other site 272558009159 ABC transporter signature motif; other site 272558009160 Walker B; other site 272558009161 D-loop; other site 272558009162 H-loop/switch region; other site 272558009163 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272558009164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558009165 dimer interface [polypeptide binding]; other site 272558009166 conserved gate region; other site 272558009167 putative PBP binding loops; other site 272558009168 ABC-ATPase subunit interface; other site 272558009169 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272558009170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558009171 dimer interface [polypeptide binding]; other site 272558009172 conserved gate region; other site 272558009173 putative PBP binding loops; other site 272558009174 ABC-ATPase subunit interface; other site 272558009175 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 272558009176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272558009177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558009178 dimerization interface [polypeptide binding]; other site 272558009179 putative DNA binding site [nucleotide binding]; other site 272558009180 putative Zn2+ binding site [ion binding]; other site 272558009181 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272558009182 active site 272558009183 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272558009184 Citrate transporter; Region: CitMHS; pfam03600 272558009185 transmembrane helices; other site 272558009186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558009187 dimerization interface [polypeptide binding]; other site 272558009188 putative DNA binding site [nucleotide binding]; other site 272558009189 putative Zn2+ binding site [ion binding]; other site 272558009190 maltose O-acetyltransferase; Provisional; Region: PRK10092 272558009191 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272558009192 active site 272558009193 substrate binding site [chemical binding]; other site 272558009194 trimer interface [polypeptide binding]; other site 272558009195 CoA binding site [chemical binding]; other site 272558009196 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272558009197 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 272558009198 Predicted integral membrane protein [Function unknown]; Region: COG5505 272558009199 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272558009200 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272558009201 active site 272558009202 Bacterial SH3 domain; Region: SH3_3; pfam08239 272558009203 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272558009204 NlpC/P60 family; Region: NLPC_P60; pfam00877 272558009205 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 272558009206 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 272558009207 active site 272558009208 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272558009209 hypothetical protein; Provisional; Region: PRK14553 272558009210 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272558009211 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 272558009212 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 272558009213 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272558009214 homodimer interface [polypeptide binding]; other site 272558009215 oligonucleotide binding site [chemical binding]; other site 272558009216 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272558009217 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 272558009218 Peptidase family M50; Region: Peptidase_M50; pfam02163 272558009219 active site 272558009220 putative substrate binding region [chemical binding]; other site 272558009221 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272558009222 Peptidase family M23; Region: Peptidase_M23; pfam01551 272558009223 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272558009224 GTP binding site; other site 272558009225 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272558009226 MoaE interaction surface [polypeptide binding]; other site 272558009227 MoeB interaction surface [polypeptide binding]; other site 272558009228 thiocarboxylated glycine; other site 272558009229 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272558009230 MoaE homodimer interface [polypeptide binding]; other site 272558009231 MoaD interaction [polypeptide binding]; other site 272558009232 active site residues [active] 272558009233 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 272558009234 Walker A motif; other site 272558009235 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272558009236 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272558009237 dimer interface [polypeptide binding]; other site 272558009238 putative functional site; other site 272558009239 putative MPT binding site; other site 272558009240 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272558009241 MPT binding site; other site 272558009242 trimer interface [polypeptide binding]; other site 272558009243 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272558009244 trimer interface [polypeptide binding]; other site 272558009245 dimer interface [polypeptide binding]; other site 272558009246 putative active site [active] 272558009247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558009248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558009249 active site 272558009250 phosphorylation site [posttranslational modification] 272558009251 intermolecular recognition site; other site 272558009252 dimerization interface [polypeptide binding]; other site 272558009253 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272558009254 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272558009255 proposed catalytic triad [active] 272558009256 conserved cys residue [active] 272558009257 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558009258 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 272558009259 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 272558009260 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272558009261 P-loop; other site 272558009262 ADP binding residues [chemical binding]; other site 272558009263 Switch I; other site 272558009264 Switch II; other site 272558009265 septum formation inhibitor; Reviewed; Region: minC; PRK00513 272558009266 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272558009267 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 272558009268 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 272558009269 rod shape-determining protein MreB; Provisional; Region: PRK13927 272558009270 MreB and similar proteins; Region: MreB_like; cd10225 272558009271 nucleotide binding site [chemical binding]; other site 272558009272 Mg binding site [ion binding]; other site 272558009273 putative protofilament interaction site [polypeptide binding]; other site 272558009274 RodZ interaction site [polypeptide binding]; other site 272558009275 hypothetical protein; Reviewed; Region: PRK00024 272558009276 Helix-hairpin-helix motif; Region: HHH; pfam00633 272558009277 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272558009278 MPN+ (JAMM) motif; other site 272558009279 Zinc-binding site [ion binding]; other site 272558009280 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272558009281 active site 272558009282 dimer interface [polypeptide binding]; other site 272558009283 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272558009284 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272558009285 GAF domain; Region: GAF_3; pfam13492 272558009286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272558009287 metal binding site [ion binding]; metal-binding site 272558009288 active site 272558009289 I-site; other site 272558009290 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272558009291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272558009292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272558009293 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272558009294 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272558009295 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272558009296 active site 272558009297 HIGH motif; other site 272558009298 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272558009299 KMSKS motif; other site 272558009300 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272558009301 tRNA binding surface [nucleotide binding]; other site 272558009302 anticodon binding site; other site 272558009303 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272558009304 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 272558009305 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 272558009306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272558009307 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272558009308 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558009309 inhibitor-cofactor binding pocket; inhibition site 272558009310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558009311 catalytic residue [active] 272558009312 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272558009313 dimer interface [polypeptide binding]; other site 272558009314 active site 272558009315 Schiff base residues; other site 272558009316 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272558009317 active site 272558009318 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272558009319 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272558009320 domain interfaces; other site 272558009321 active site 272558009322 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 272558009323 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 272558009324 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 272558009325 tRNA; other site 272558009326 putative tRNA binding site [nucleotide binding]; other site 272558009327 putative NADP binding site [chemical binding]; other site 272558009328 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 272558009329 Predicted GTPase [General function prediction only]; Region: COG0218 272558009330 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272558009331 G1 box; other site 272558009332 GTP/Mg2+ binding site [chemical binding]; other site 272558009333 Switch I region; other site 272558009334 G2 box; other site 272558009335 G3 box; other site 272558009336 Switch II region; other site 272558009337 G4 box; other site 272558009338 G5 box; other site 272558009339 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272558009340 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272558009341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272558009342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558009343 Walker A motif; other site 272558009344 ATP binding site [chemical binding]; other site 272558009345 Walker B motif; other site 272558009346 arginine finger; other site 272558009347 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272558009348 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 272558009349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558009350 Walker A motif; other site 272558009351 ATP binding site [chemical binding]; other site 272558009352 Walker B motif; other site 272558009353 arginine finger; other site 272558009354 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272558009355 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272558009356 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272558009357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558009358 Walker A motif; other site 272558009359 ATP binding site [chemical binding]; other site 272558009360 Walker B motif; other site 272558009361 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272558009362 trigger factor; Provisional; Region: tig; PRK01490 272558009363 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272558009364 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272558009365 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272558009366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558009367 binding surface 272558009368 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272558009369 TPR motif; other site 272558009370 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272558009371 substrate binding site [chemical binding]; other site 272558009372 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272558009373 substrate binding site [chemical binding]; other site 272558009374 ligand binding site [chemical binding]; other site 272558009375 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272558009376 2-isopropylmalate synthase; Validated; Region: PRK00915 272558009377 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272558009378 active site 272558009379 catalytic residues [active] 272558009380 metal binding site [ion binding]; metal-binding site 272558009381 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272558009382 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272558009383 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272558009384 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272558009385 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272558009386 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272558009387 putative valine binding site [chemical binding]; other site 272558009388 dimer interface [polypeptide binding]; other site 272558009389 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272558009390 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272558009391 PYR/PP interface [polypeptide binding]; other site 272558009392 dimer interface [polypeptide binding]; other site 272558009393 TPP binding site [chemical binding]; other site 272558009394 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272558009395 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272558009396 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 272558009397 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272558009398 active site 272558009399 metal binding site [ion binding]; metal-binding site 272558009400 homotetramer interface [polypeptide binding]; other site 272558009401 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272558009402 active site 272558009403 dimerization interface [polypeptide binding]; other site 272558009404 ribonuclease PH; Reviewed; Region: rph; PRK00173 272558009405 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272558009406 hexamer interface [polypeptide binding]; other site 272558009407 active site 272558009408 Sporulation and spore germination; Region: Germane; pfam10646 272558009409 Spore germination protein [General function prediction only]; Region: COG5401 272558009410 Sporulation and spore germination; Region: Germane; pfam10646 272558009411 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 272558009412 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558009413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272558009414 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272558009415 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272558009416 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272558009417 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272558009418 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272558009419 dimerization domain swap beta strand [polypeptide binding]; other site 272558009420 regulatory protein interface [polypeptide binding]; other site 272558009421 active site 272558009422 regulatory phosphorylation site [posttranslational modification]; other site 272558009423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558009424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558009425 DNA binding residues [nucleotide binding] 272558009426 dimerization interface [polypeptide binding]; other site 272558009427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558009428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558009429 Coenzyme A binding pocket [chemical binding]; other site 272558009430 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558009431 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272558009432 Predicted membrane protein [Function unknown]; Region: COG2364 272558009433 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 272558009434 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272558009435 homotrimer interaction site [polypeptide binding]; other site 272558009436 putative active site [active] 272558009437 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 272558009438 Protein of unknown function (DUF817); Region: DUF817; pfam05675 272558009439 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 272558009440 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 272558009441 nudix motif; other site 272558009442 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272558009443 active site 272558009444 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 272558009445 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272558009446 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272558009447 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 272558009448 L-aspartate oxidase; Provisional; Region: PRK06175 272558009449 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272558009450 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 272558009451 putative Iron-sulfur protein interface [polypeptide binding]; other site 272558009452 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 272558009453 proximal heme binding site [chemical binding]; other site 272558009454 distal heme binding site [chemical binding]; other site 272558009455 putative dimer interface [polypeptide binding]; other site 272558009456 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272558009457 Cation transport protein; Region: TrkH; cl17365 272558009458 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 272558009459 aspartate kinase; Reviewed; Region: PRK06635 272558009460 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272558009461 putative nucleotide binding site [chemical binding]; other site 272558009462 putative catalytic residues [active] 272558009463 putative Mg ion binding site [ion binding]; other site 272558009464 putative aspartate binding site [chemical binding]; other site 272558009465 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272558009466 putative allosteric regulatory site; other site 272558009467 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 272558009468 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272558009469 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272558009470 GIY-YIG motif/motif A; other site 272558009471 active site 272558009472 catalytic site [active] 272558009473 putative DNA binding site [nucleotide binding]; other site 272558009474 metal binding site [ion binding]; metal-binding site 272558009475 UvrB/uvrC motif; Region: UVR; pfam02151 272558009476 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272558009477 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272558009478 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272558009479 catalytic residues [active] 272558009480 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272558009481 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272558009482 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272558009483 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272558009484 Ligand binding site [chemical binding]; other site 272558009485 enoyl-CoA hydratase; Provisional; Region: PRK07658 272558009486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558009487 substrate binding site [chemical binding]; other site 272558009488 oxyanion hole (OAH) forming residues; other site 272558009489 trimer interface [polypeptide binding]; other site 272558009490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558009491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558009492 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 272558009493 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 272558009494 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 272558009495 acyl-activating enzyme (AAE) consensus motif; other site 272558009496 putative AMP binding site [chemical binding]; other site 272558009497 putative active site [active] 272558009498 putative CoA binding site [chemical binding]; other site 272558009499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 272558009500 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 272558009501 acyl-activating enzyme (AAE) consensus motif; other site 272558009502 putative AMP binding site [chemical binding]; other site 272558009503 putative active site [active] 272558009504 putative CoA binding site [chemical binding]; other site 272558009505 Predicted membrane protein [Function unknown]; Region: COG3766 272558009506 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 272558009507 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 272558009508 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 272558009509 MutS domain III; Region: MutS_III; pfam05192 272558009510 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 272558009511 Walker A/P-loop; other site 272558009512 ATP binding site [chemical binding]; other site 272558009513 Q-loop/lid; other site 272558009514 ABC transporter signature motif; other site 272558009515 Walker B; other site 272558009516 D-loop; other site 272558009517 H-loop/switch region; other site 272558009518 Smr domain; Region: Smr; pfam01713 272558009519 hypothetical protein; Provisional; Region: PRK08609 272558009520 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 272558009521 active site 272558009522 primer binding site [nucleotide binding]; other site 272558009523 NTP binding site [chemical binding]; other site 272558009524 metal binding triad [ion binding]; metal-binding site 272558009525 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 272558009526 active site 272558009527 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272558009528 Cell division protein ZapA; Region: ZapA; cl01146 272558009529 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272558009530 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272558009531 putative tRNA-binding site [nucleotide binding]; other site 272558009532 B3/4 domain; Region: B3_4; pfam03483 272558009533 tRNA synthetase B5 domain; Region: B5; smart00874 272558009534 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272558009535 dimer interface [polypeptide binding]; other site 272558009536 motif 1; other site 272558009537 motif 3; other site 272558009538 motif 2; other site 272558009539 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272558009540 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272558009541 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272558009542 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272558009543 dimer interface [polypeptide binding]; other site 272558009544 motif 1; other site 272558009545 active site 272558009546 motif 2; other site 272558009547 motif 3; other site 272558009548 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272558009549 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272558009550 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272558009551 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 272558009552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 272558009553 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272558009554 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558009555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558009556 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272558009557 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272558009558 oligomer interface [polypeptide binding]; other site 272558009559 active site residues [active] 272558009560 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 272558009561 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 272558009562 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272558009563 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272558009564 FtsX-like permease family; Region: FtsX; pfam02687 272558009565 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558009566 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558009567 Walker A/P-loop; other site 272558009568 ATP binding site [chemical binding]; other site 272558009569 Q-loop/lid; other site 272558009570 ABC transporter signature motif; other site 272558009571 Walker B; other site 272558009572 D-loop; other site 272558009573 H-loop/switch region; other site 272558009574 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 272558009575 HlyD family secretion protein; Region: HlyD_3; pfam13437 272558009576 Yip1 domain; Region: Yip1; pfam04893 272558009577 Predicted transcriptional regulator [Transcription]; Region: COG1959 272558009578 Rrf2 family protein; Region: rrf2_super; TIGR00738 272558009579 Uncharacterized small protein [Function unknown]; Region: COG5583 272558009580 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272558009581 substrate binding pocket [chemical binding]; other site 272558009582 membrane-bound complex binding site; other site 272558009583 hinge residues; other site 272558009584 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272558009585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558009586 dimer interface [polypeptide binding]; other site 272558009587 conserved gate region; other site 272558009588 putative PBP binding loops; other site 272558009589 ABC-ATPase subunit interface; other site 272558009590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558009591 dimer interface [polypeptide binding]; other site 272558009592 conserved gate region; other site 272558009593 putative PBP binding loops; other site 272558009594 ABC-ATPase subunit interface; other site 272558009595 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 272558009596 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 272558009597 Walker A/P-loop; other site 272558009598 ATP binding site [chemical binding]; other site 272558009599 Q-loop/lid; other site 272558009600 ABC transporter signature motif; other site 272558009601 Walker B; other site 272558009602 D-loop; other site 272558009603 H-loop/switch region; other site 272558009604 TOBE-like domain; Region: TOBE_3; pfam12857 272558009605 Pathogenicity locus; Region: Cdd1; pfam11731 272558009606 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272558009607 oligomer interface [polypeptide binding]; other site 272558009608 active site 272558009609 metal binding site [ion binding]; metal-binding site 272558009610 dUTPase; Region: dUTPase_2; pfam08761 272558009611 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 272558009612 active site 272558009613 homodimer interface [polypeptide binding]; other site 272558009614 metal binding site [ion binding]; metal-binding site 272558009615 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272558009616 Predicted membrane protein [Function unknown]; Region: COG3326 272558009617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558009618 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558009619 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558009620 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558009621 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272558009622 23S rRNA binding site [nucleotide binding]; other site 272558009623 L21 binding site [polypeptide binding]; other site 272558009624 L13 binding site [polypeptide binding]; other site 272558009625 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272558009626 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272558009627 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272558009628 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272558009629 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272558009630 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272558009631 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272558009632 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272558009633 active site 272558009634 dimer interface [polypeptide binding]; other site 272558009635 motif 1; other site 272558009636 motif 2; other site 272558009637 motif 3; other site 272558009638 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272558009639 anticodon binding site; other site 272558009640 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 272558009641 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 272558009642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558009643 FeS/SAM binding site; other site 272558009644 primosomal protein DnaI; Reviewed; Region: PRK08939 272558009645 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 272558009646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558009647 Walker A motif; other site 272558009648 ATP binding site [chemical binding]; other site 272558009649 Walker B motif; other site 272558009650 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272558009651 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272558009652 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272558009653 ATP cone domain; Region: ATP-cone; pfam03477 272558009654 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272558009655 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 272558009656 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 272558009657 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272558009658 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272558009659 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272558009660 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272558009661 CoA-binding site [chemical binding]; other site 272558009662 ATP-binding [chemical binding]; other site 272558009663 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 272558009664 Domain of unknown function DUF; Region: DUF204; pfam02659 272558009665 Domain of unknown function DUF; Region: DUF204; pfam02659 272558009666 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272558009667 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272558009668 DNA binding site [nucleotide binding] 272558009669 catalytic residue [active] 272558009670 H2TH interface [polypeptide binding]; other site 272558009671 putative catalytic residues [active] 272558009672 turnover-facilitating residue; other site 272558009673 intercalation triad [nucleotide binding]; other site 272558009674 8OG recognition residue [nucleotide binding]; other site 272558009675 putative reading head residues; other site 272558009676 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272558009677 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272558009678 DNA polymerase I; Provisional; Region: PRK05755 272558009679 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272558009680 active site 272558009681 metal binding site 1 [ion binding]; metal-binding site 272558009682 putative 5' ssDNA interaction site; other site 272558009683 metal binding site 3; metal-binding site 272558009684 metal binding site 2 [ion binding]; metal-binding site 272558009685 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272558009686 putative DNA binding site [nucleotide binding]; other site 272558009687 putative metal binding site [ion binding]; other site 272558009688 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272558009689 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272558009690 active site 272558009691 DNA binding site [nucleotide binding] 272558009692 catalytic site [active] 272558009693 HflC protein; Region: hflC; TIGR01932 272558009694 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 272558009695 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 272558009696 HflK protein; Region: hflK; TIGR01933 272558009697 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272558009698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558009699 dimerization interface [polypeptide binding]; other site 272558009700 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272558009701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558009702 putative active site [active] 272558009703 heme pocket [chemical binding]; other site 272558009704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558009705 dimer interface [polypeptide binding]; other site 272558009706 phosphorylation site [posttranslational modification] 272558009707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558009708 ATP binding site [chemical binding]; other site 272558009709 Mg2+ binding site [ion binding]; other site 272558009710 G-X-G motif; other site 272558009711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558009712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558009713 active site 272558009714 phosphorylation site [posttranslational modification] 272558009715 intermolecular recognition site; other site 272558009716 dimerization interface [polypeptide binding]; other site 272558009717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558009718 DNA binding site [nucleotide binding] 272558009719 malate dehydrogenase; Reviewed; Region: PRK06223 272558009720 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 272558009721 NAD(P) binding site [chemical binding]; other site 272558009722 dimer interface [polypeptide binding]; other site 272558009723 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272558009724 substrate binding site [chemical binding]; other site 272558009725 isocitrate dehydrogenase; Reviewed; Region: PRK07006 272558009726 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272558009727 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 272558009728 dimer interface [polypeptide binding]; other site 272558009729 active site 272558009730 citrylCoA binding site [chemical binding]; other site 272558009731 oxalacetate/citrate binding site [chemical binding]; other site 272558009732 coenzyme A binding site [chemical binding]; other site 272558009733 catalytic triad [active] 272558009734 Predicted membrane protein [Function unknown]; Region: COG2707 272558009735 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 272558009736 pyruvate kinase; Provisional; Region: PRK06354 272558009737 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272558009738 domain interfaces; other site 272558009739 active site 272558009740 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 272558009741 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272558009742 active site 272558009743 ADP/pyrophosphate binding site [chemical binding]; other site 272558009744 dimerization interface [polypeptide binding]; other site 272558009745 allosteric effector site; other site 272558009746 fructose-1,6-bisphosphate binding site; other site 272558009747 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272558009748 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272558009749 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272558009750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558009751 DNA-binding site [nucleotide binding]; DNA binding site 272558009752 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272558009753 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 272558009754 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272558009755 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272558009756 putative NAD(P) binding site [chemical binding]; other site 272558009757 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 272558009758 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272558009759 active site 272558009760 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272558009761 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272558009762 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272558009763 generic binding surface II; other site 272558009764 generic binding surface I; other site 272558009765 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 272558009766 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272558009767 DHH family; Region: DHH; pfam01368 272558009768 DHHA1 domain; Region: DHHA1; pfam02272 272558009769 YtpI-like protein; Region: YtpI; pfam14007 272558009770 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 272558009771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272558009772 DNA-binding site [nucleotide binding]; DNA binding site 272558009773 DRTGG domain; Region: DRTGG; pfam07085 272558009774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 272558009775 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 272558009776 active site 2 [active] 272558009777 active site 1 [active] 272558009778 metal-dependent hydrolase; Provisional; Region: PRK00685 272558009779 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272558009780 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272558009781 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272558009782 active site 272558009783 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272558009784 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272558009785 hexamer interface [polypeptide binding]; other site 272558009786 ligand binding site [chemical binding]; other site 272558009787 putative active site [active] 272558009788 NAD(P) binding site [chemical binding]; other site 272558009789 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 272558009790 classical (c) SDRs; Region: SDR_c; cd05233 272558009791 NAD(P) binding site [chemical binding]; other site 272558009792 active site 272558009793 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272558009794 Ligand Binding Site [chemical binding]; other site 272558009795 argininosuccinate lyase; Provisional; Region: PRK00855 272558009796 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272558009797 active sites [active] 272558009798 tetramer interface [polypeptide binding]; other site 272558009799 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272558009800 ANP binding site [chemical binding]; other site 272558009801 Substrate Binding Site II [chemical binding]; other site 272558009802 Substrate Binding Site I [chemical binding]; other site 272558009803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558009804 EcsC protein family; Region: EcsC; pfam12787 272558009805 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272558009806 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272558009807 generic binding surface I; other site 272558009808 generic binding surface II; other site 272558009809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558009810 Zn2+ binding site [ion binding]; other site 272558009811 Mg2+ binding site [ion binding]; other site 272558009812 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272558009813 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272558009814 nucleotide binding site [chemical binding]; other site 272558009815 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272558009816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558009817 S-adenosylmethionine binding site [chemical binding]; other site 272558009818 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272558009819 dimer interface [polypeptide binding]; other site 272558009820 catalytic triad [active] 272558009821 peroxidatic and resolving cysteines [active] 272558009822 Uncharacterized conserved protein [Function unknown]; Region: COG3874 272558009823 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 272558009824 RDD family; Region: RDD; pfam06271 272558009825 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272558009826 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272558009827 tandem repeat interface [polypeptide binding]; other site 272558009828 oligomer interface [polypeptide binding]; other site 272558009829 active site residues [active] 272558009830 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 272558009831 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 272558009832 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 272558009833 active site 272558009834 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272558009835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272558009836 acyl-activating enzyme (AAE) consensus motif; other site 272558009837 AMP binding site [chemical binding]; other site 272558009838 active site 272558009839 CoA binding site [chemical binding]; other site 272558009840 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272558009841 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272558009842 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272558009843 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272558009844 Ligand Binding Site [chemical binding]; other site 272558009845 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272558009846 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558009847 catalytic residue [active] 272558009848 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 272558009849 putative minor structural protein; Region: PHA01351 272558009850 Protein of unknown function N-terminal domain (DUF2450); Region: DUF2450; cl19949 272558009851 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 272558009852 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 272558009853 active site 272558009854 dimer interface [polypeptide binding]; other site 272558009855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558009856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558009857 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272558009858 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272558009859 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272558009860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558009861 RNA binding surface [nucleotide binding]; other site 272558009862 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272558009863 putative transporter; Provisional; Region: PRK10054 272558009864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558009865 putative substrate translocation pore; other site 272558009866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558009867 dimerization interface [polypeptide binding]; other site 272558009868 putative DNA binding site [nucleotide binding]; other site 272558009869 putative Zn2+ binding site [ion binding]; other site 272558009870 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272558009871 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272558009872 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558009873 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558009874 Walker A/P-loop; other site 272558009875 ATP binding site [chemical binding]; other site 272558009876 Q-loop/lid; other site 272558009877 ABC transporter signature motif; other site 272558009878 Walker B; other site 272558009879 D-loop; other site 272558009880 H-loop/switch region; other site 272558009881 Predicted membrane protein [Function unknown]; Region: COG1470 272558009882 Domain of unknown function (DUF4625); Region: DUF4625; pfam15418 272558009883 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 272558009884 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 272558009885 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558009886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558009887 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 272558009888 DNA binding residues [nucleotide binding] 272558009889 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 272558009890 Putative zinc-finger; Region: zf-HC2; pfam13490 272558009891 Anti-sigma-K factor rskA; Region: RskA; pfam10099 272558009892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558009893 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272558009894 active site 272558009895 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272558009896 active site 272558009897 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272558009898 active site 272558009899 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272558009900 active site 272558009901 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558009902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558009903 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272558009904 DNA binding residues [nucleotide binding] 272558009905 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272558009906 MgtE intracellular N domain; Region: MgtE_N; pfam03448 272558009907 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272558009908 Divalent cation transporter; Region: MgtE; pfam01769 272558009909 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272558009910 MgtC family; Region: MgtC; pfam02308 272558009911 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272558009912 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 272558009913 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272558009914 active site 272558009915 HIGH motif; other site 272558009916 dimer interface [polypeptide binding]; other site 272558009917 KMSKS motif; other site 272558009918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558009919 RNA binding surface [nucleotide binding]; other site 272558009920 Transglycosylase; Region: Transgly; pfam00912 272558009921 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272558009922 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272558009923 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558009924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558009925 DNA binding site [nucleotide binding] 272558009926 domain linker motif; other site 272558009927 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272558009928 ligand binding site [chemical binding]; other site 272558009929 dimerization interface [polypeptide binding]; other site 272558009930 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 272558009931 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 272558009932 active site 272558009933 catalytic residues [active] 272558009934 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 272558009935 ligand binding site [chemical binding]; other site 272558009936 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 272558009937 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 272558009938 active site 272558009939 active site 272558009940 catalytic residues [active] 272558009941 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 272558009942 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 272558009943 active site 272558009944 active site 272558009945 catalytic residues [active] 272558009946 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 272558009947 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 272558009948 active site 272558009949 active site 272558009950 catalytic residues [active] 272558009951 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558009952 acetyl-CoA synthetase; Provisional; Region: PRK04319 272558009953 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 272558009954 active site 272558009955 acyl-activating enzyme (AAE) consensus motif; other site 272558009956 putative CoA binding site [chemical binding]; other site 272558009957 AMP binding site [chemical binding]; other site 272558009958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558009959 FOG: CBS domain [General function prediction only]; Region: COG0517 272558009960 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 272558009961 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 272558009962 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 272558009963 active site 272558009964 Zn binding site [ion binding]; other site 272558009965 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272558009966 flagellar motor protein MotS; Reviewed; Region: PRK06925 272558009967 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272558009968 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272558009969 ligand binding site [chemical binding]; other site 272558009970 flagellar motor protein MotP; Reviewed; Region: PRK06926 272558009971 catabolite control protein A; Region: ccpA; TIGR01481 272558009972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558009973 DNA binding site [nucleotide binding] 272558009974 domain linker motif; other site 272558009975 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 272558009976 dimerization interface [polypeptide binding]; other site 272558009977 effector binding site; other site 272558009978 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 272558009979 Chorismate mutase type II; Region: CM_2; cl00693 272558009980 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 272558009981 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272558009982 Cell division protein FtsA; Region: FtsA; smart00842 272558009983 Cell division protein FtsA; Region: FtsA; pfam14450 272558009984 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272558009985 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 272558009986 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 272558009987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558009988 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558009989 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558009990 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558009991 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272558009992 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272558009993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272558009994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272558009995 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 272558009996 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 272558009997 active site 272558009998 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272558009999 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272558010000 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272558010001 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 272558010002 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272558010003 putative tRNA-binding site [nucleotide binding]; other site 272558010004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4848 272558010005 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272558010006 catalytic residues [active] 272558010007 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 272558010008 YtoQ family protein; Region: YtoQ_fam; TIGR03646 272558010009 NTPase; Reviewed; Region: PRK03114 272558010010 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272558010011 oligomer interface [polypeptide binding]; other site 272558010012 active site 272558010013 metal binding site [ion binding]; metal-binding site 272558010014 Predicted small secreted protein [Function unknown]; Region: COG5584 272558010015 hypothetical protein; Provisional; Region: PRK12378 272558010016 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272558010017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558010018 S-adenosylmethionine binding site [chemical binding]; other site 272558010019 YtzH-like protein; Region: YtzH; pfam14165 272558010020 Phosphotransferase enzyme family; Region: APH; pfam01636 272558010021 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272558010022 active site 272558010023 substrate binding site [chemical binding]; other site 272558010024 ATP binding site [chemical binding]; other site 272558010025 pullulanase, type I; Region: pulA_typeI; TIGR02104 272558010026 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 272558010027 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 272558010028 Ca binding site [ion binding]; other site 272558010029 active site 272558010030 catalytic site [active] 272558010031 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 272558010032 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 272558010033 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 272558010034 putative active site [active] 272558010035 putative substrate binding site [chemical binding]; other site 272558010036 putative cosubstrate binding site; other site 272558010037 catalytic site [active] 272558010038 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 272558010039 Nuclease-related domain; Region: NERD; pfam08378 272558010040 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 272558010041 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 272558010042 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 272558010043 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272558010044 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272558010045 cysteine synthase; Region: PLN02565 272558010046 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272558010047 dimer interface [polypeptide binding]; other site 272558010048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558010049 catalytic residue [active] 272558010050 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272558010051 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 272558010052 active site 272558010053 metal binding site [ion binding]; metal-binding site 272558010054 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272558010055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272558010056 RNA binding surface [nucleotide binding]; other site 272558010057 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272558010058 active site 272558010059 uracil binding [chemical binding]; other site 272558010060 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 272558010061 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272558010062 cell division protein FtsW; Region: ftsW; TIGR02614 272558010063 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272558010064 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272558010065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558010066 HI0933-like protein; Region: HI0933_like; pfam03486 272558010067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558010068 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272558010069 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272558010070 active site 272558010071 HIGH motif; other site 272558010072 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272558010073 KMSKS motif; other site 272558010074 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272558010075 tRNA binding surface [nucleotide binding]; other site 272558010076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558010077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558010078 putative substrate translocation pore; other site 272558010079 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272558010080 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272558010081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558010082 catalytic residue [active] 272558010083 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 272558010084 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272558010085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272558010086 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 272558010087 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 272558010088 active site clefts [active] 272558010089 zinc binding site [ion binding]; other site 272558010090 dimer interface [polypeptide binding]; other site 272558010091 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 272558010092 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272558010093 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272558010094 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272558010095 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272558010096 trimer interface [polypeptide binding]; other site 272558010097 putative metal binding site [ion binding]; other site 272558010098 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272558010099 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272558010100 intersubunit interface [polypeptide binding]; other site 272558010101 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558010102 ABC-ATPase subunit interface; other site 272558010103 dimer interface [polypeptide binding]; other site 272558010104 putative PBP binding regions; other site 272558010105 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558010106 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272558010107 Walker A/P-loop; other site 272558010108 ATP binding site [chemical binding]; other site 272558010109 Q-loop/lid; other site 272558010110 ABC transporter signature motif; other site 272558010111 Walker B; other site 272558010112 D-loop; other site 272558010113 H-loop/switch region; other site 272558010114 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 272558010115 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 272558010116 active site 272558010117 catalytic site [active] 272558010118 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272558010119 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272558010120 Walker A/P-loop; other site 272558010121 ATP binding site [chemical binding]; other site 272558010122 Q-loop/lid; other site 272558010123 ABC transporter signature motif; other site 272558010124 Walker B; other site 272558010125 D-loop; other site 272558010126 H-loop/switch region; other site 272558010127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558010128 ABC-ATPase subunit interface; other site 272558010129 dimer interface [polypeptide binding]; other site 272558010130 putative PBP binding regions; other site 272558010131 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 272558010132 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272558010133 intersubunit interface [polypeptide binding]; other site 272558010134 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272558010135 heme-binding site [chemical binding]; other site 272558010136 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272558010137 heme-binding site [chemical binding]; other site 272558010138 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272558010139 heme-binding site [chemical binding]; other site 272558010140 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 272558010141 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272558010142 heme-binding site [chemical binding]; other site 272558010143 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272558010144 heme-binding site [chemical binding]; other site 272558010145 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 272558010146 heme uptake protein IsdC; Region: IsdC; TIGR03656 272558010147 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272558010148 heme-binding site [chemical binding]; other site 272558010149 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272558010150 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272558010151 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272558010152 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272558010153 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 272558010154 active site 272558010155 substrate-binding site [chemical binding]; other site 272558010156 metal-binding site [ion binding] 272558010157 ATP binding site [chemical binding]; other site 272558010158 Predicted transcriptional regulators [Transcription]; Region: COG1733 272558010159 putative DNA binding site [nucleotide binding]; other site 272558010160 dimerization interface [polypeptide binding]; other site 272558010161 putative Zn2+ binding site [ion binding]; other site 272558010162 Predicted membrane protein [Function unknown]; Region: COG2259 272558010163 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 272558010164 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 272558010165 putative metal binding site [ion binding]; other site 272558010166 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272558010167 active site 272558010168 metal binding site [ion binding]; metal-binding site 272558010169 Dienelactone hydrolase family; Region: DLH; pfam01738 272558010170 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558010171 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 272558010172 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 272558010173 nudix motif; other site 272558010174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558010175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558010176 putative substrate translocation pore; other site 272558010177 YwpF-like protein; Region: YwpF; pfam14183 272558010178 Sporulation inhibitor A; Region: Sda; pfam08970 272558010179 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272558010180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558010181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558010182 homodimer interface [polypeptide binding]; other site 272558010183 catalytic residue [active] 272558010184 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272558010185 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 272558010186 dimerization interface [polypeptide binding]; other site 272558010187 ligand binding site [chemical binding]; other site 272558010188 NADP binding site [chemical binding]; other site 272558010189 catalytic site [active] 272558010190 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 272558010191 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272558010192 tetramerization interface [polypeptide binding]; other site 272558010193 NAD(P) binding site [chemical binding]; other site 272558010194 catalytic residues [active] 272558010195 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 272558010196 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 272558010197 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 272558010198 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 272558010199 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558010200 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558010201 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558010202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272558010203 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272558010204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558010205 DNA-binding site [nucleotide binding]; DNA binding site 272558010206 UTRA domain; Region: UTRA; pfam07702 272558010207 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272558010208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272558010209 active site 272558010210 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272558010211 putative trimer interface [polypeptide binding]; other site 272558010212 putative CoA binding site [chemical binding]; other site 272558010213 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272558010214 putative trimer interface [polypeptide binding]; other site 272558010215 putative CoA binding site [chemical binding]; other site 272558010216 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272558010217 putative active site [active] 272558010218 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 272558010219 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558010220 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272558010221 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272558010222 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272558010223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558010224 conserved gate region; other site 272558010225 dimer interface [polypeptide binding]; other site 272558010226 putative PBP binding loops; other site 272558010227 ABC-ATPase subunit interface; other site 272558010228 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 272558010229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272558010230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558010231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558010232 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 272558010233 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 272558010234 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272558010235 Cu(I) binding site [ion binding]; other site 272558010236 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 272558010237 Ion channel; Region: Ion_trans_2; pfam07885 272558010238 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272558010239 TrkA-N domain; Region: TrkA_N; pfam02254 272558010240 YugN-like family; Region: YugN; pfam08868 272558010241 hypothetical protein; Provisional; Region: PRK14707 272558010242 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272558010243 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272558010244 active site 272558010245 dimer interface [polypeptide binding]; other site 272558010246 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272558010247 dimer interface [polypeptide binding]; other site 272558010248 active site 272558010249 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272558010250 dimer interface [polypeptide binding]; other site 272558010251 active site 272558010252 metal binding site [ion binding]; metal-binding site 272558010253 Uncharacterized conserved protein [Function unknown]; Region: COG2155 272558010254 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272558010255 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272558010256 general stress protein 13; Validated; Region: PRK08059 272558010257 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272558010258 RNA binding site [nucleotide binding]; other site 272558010259 helicase 45; Provisional; Region: PTZ00424 272558010260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272558010261 ATP binding site [chemical binding]; other site 272558010262 putative Mg++ binding site [ion binding]; other site 272558010263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558010264 nucleotide binding region [chemical binding]; other site 272558010265 ATP-binding site [chemical binding]; other site 272558010266 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272558010267 substrate binding site [chemical binding]; other site 272558010268 multimerization interface [polypeptide binding]; other site 272558010269 ATP binding site [chemical binding]; other site 272558010270 aspartate aminotransferase; Provisional; Region: PRK05764 272558010271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272558010272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558010273 homodimer interface [polypeptide binding]; other site 272558010274 catalytic residue [active] 272558010275 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558010276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272558010277 Uncharacterized conserved protein [Function unknown]; Region: COG5506 272558010278 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 272558010279 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272558010280 histone-like DNA-binding protein HU; Region: HU; cd13831 272558010281 dimer interface [polypeptide binding]; other site 272558010282 DNA binding site [nucleotide binding] 272558010283 RDD family; Region: RDD; pfam06271 272558010284 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272558010285 Predicted permease [General function prediction only]; Region: COG2056 272558010286 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 272558010287 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272558010288 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272558010289 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 272558010290 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 272558010291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558010292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272558010293 DNA binding residues [nucleotide binding] 272558010294 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272558010295 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272558010296 substrate binding site; other site 272558010297 tetramer interface; other site 272558010298 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272558010299 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272558010300 NAD binding site [chemical binding]; other site 272558010301 substrate binding site [chemical binding]; other site 272558010302 homodimer interface [polypeptide binding]; other site 272558010303 active site 272558010304 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272558010305 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272558010306 NADP binding site [chemical binding]; other site 272558010307 active site 272558010308 putative substrate binding site [chemical binding]; other site 272558010309 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 272558010310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272558010311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272558010312 active site 272558010313 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 272558010314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 272558010315 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 272558010316 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 272558010317 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 272558010318 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 272558010319 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272558010320 active site 272558010321 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272558010322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272558010323 active site 272558010324 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272558010325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558010326 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272558010327 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272558010328 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272558010329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558010330 NAD(P) binding site [chemical binding]; other site 272558010331 active site 272558010332 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272558010333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558010334 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272558010335 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272558010336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558010337 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 272558010338 transmembrane helices; other site 272558010339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272558010340 TrkA-C domain; Region: TrkA_C; pfam02080 272558010341 TrkA-C domain; Region: TrkA_C; pfam02080 272558010342 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272558010343 ligand-binding site [chemical binding]; other site 272558010344 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 272558010345 ATP-sulfurylase; Region: ATPS; cd00517 272558010346 active site 272558010347 HXXH motif; other site 272558010348 flexible loop; other site 272558010349 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 272558010350 DNA topoisomerase III; Provisional; Region: PRK07726 272558010351 active site 272558010352 putative interdomain interaction site [polypeptide binding]; other site 272558010353 putative metal-binding site [ion binding]; other site 272558010354 putative nucleotide binding site [chemical binding]; other site 272558010355 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272558010356 domain I; other site 272558010357 DNA binding groove [nucleotide binding] 272558010358 phosphate binding site [ion binding]; other site 272558010359 domain II; other site 272558010360 domain III; other site 272558010361 nucleotide binding site [chemical binding]; other site 272558010362 catalytic site [active] 272558010363 domain IV; other site 272558010364 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272558010365 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 272558010366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558010367 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 272558010368 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 272558010369 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272558010370 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272558010371 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272558010372 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 272558010373 DctM-like transporters; Region: DctM; pfam06808 272558010374 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272558010375 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272558010376 probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362 272558010377 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272558010378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558010379 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272558010380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 272558010381 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 272558010382 dihydroxyacetone kinase, DhaK subunit; Region: dhaK1; TIGR02363 272558010383 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 272558010384 Phosphotransferase enzyme family; Region: APH; pfam01636 272558010385 active site 272558010386 ATP binding site [chemical binding]; other site 272558010387 substrate binding site [chemical binding]; other site 272558010388 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 272558010389 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272558010390 interface (dimer of trimers) [polypeptide binding]; other site 272558010391 Substrate-binding/catalytic site; other site 272558010392 Zn-binding sites [ion binding]; other site 272558010393 Divergent PAP2 family; Region: DUF212; pfam02681 272558010394 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 272558010395 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272558010396 cobalamin binding residues [chemical binding]; other site 272558010397 putative BtuC binding residues; other site 272558010398 dimer interface [polypeptide binding]; other site 272558010399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272558010400 Putative membrane protein; Region: YuiB; pfam14068 272558010401 chaperone protein DnaJ; Provisional; Region: PRK14293 272558010402 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272558010403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558010404 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272558010405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558010406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558010407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558010408 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558010409 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558010410 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558010411 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272558010412 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 272558010413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558010414 FeS/SAM binding site; other site 272558010415 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272558010416 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272558010417 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272558010418 hypothetical protein; Provisional; Region: PRK13669 272558010419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558010420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558010421 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272558010422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558010423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 272558010424 putative transposase OrfB; Reviewed; Region: PHA02517 272558010425 HTH-like domain; Region: HTH_21; pfam13276 272558010426 Integrase core domain; Region: rve; pfam00665 272558010427 Integrase core domain; Region: rve_3; pfam13683 272558010428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272558010429 Transposase; Region: HTH_Tnp_1; cl17663 272558010430 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272558010431 homoserine kinase; Provisional; Region: PRK01212 272558010432 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272558010433 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272558010434 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 272558010435 homodimer interface [polypeptide binding]; other site 272558010436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558010437 catalytic residue [active] 272558010438 homoserine dehydrogenase; Provisional; Region: PRK06349 272558010439 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272558010440 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272558010441 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272558010442 spore coat protein YutH; Region: spore_yutH; TIGR02905 272558010443 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272558010444 tetramer interfaces [polypeptide binding]; other site 272558010445 binuclear metal-binding site [ion binding]; other site 272558010446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558010447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558010448 dimer interface [polypeptide binding]; other site 272558010449 phosphorylation site [posttranslational modification] 272558010450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558010451 ATP binding site [chemical binding]; other site 272558010452 Mg2+ binding site [ion binding]; other site 272558010453 G-X-G motif; other site 272558010454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558010455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558010456 active site 272558010457 phosphorylation site [posttranslational modification] 272558010458 intermolecular recognition site; other site 272558010459 dimerization interface [polypeptide binding]; other site 272558010460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558010461 DNA binding site [nucleotide binding] 272558010462 Predicted membrane protein [Function unknown]; Region: COG2311 272558010463 Protein of unknown function (DUF418); Region: DUF418; pfam04235 272558010464 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 272558010465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558010466 active site 272558010467 motif I; other site 272558010468 motif II; other site 272558010469 Predicted transcriptional regulator [Transcription]; Region: COG2345 272558010470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558010471 putative DNA binding site [nucleotide binding]; other site 272558010472 putative Zn2+ binding site [ion binding]; other site 272558010473 Uncharacterized conserved protein [Function unknown]; Region: COG2445 272558010474 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272558010475 putative active site [active] 272558010476 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 272558010477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 272558010478 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 272558010479 lipoyl synthase; Provisional; Region: PRK05481 272558010480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272558010481 FeS/SAM binding site; other site 272558010482 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272558010483 Peptidase family M23; Region: Peptidase_M23; pfam01551 272558010484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558010485 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 272558010486 Na2 binding site [ion binding]; other site 272558010487 putative substrate binding site 1 [chemical binding]; other site 272558010488 Na binding site 1 [ion binding]; other site 272558010489 putative substrate binding site 2 [chemical binding]; other site 272558010490 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272558010491 TM-ABC transporter signature motif; other site 272558010492 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272558010493 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272558010494 Walker A/P-loop; other site 272558010495 ATP binding site [chemical binding]; other site 272558010496 Q-loop/lid; other site 272558010497 ABC transporter signature motif; other site 272558010498 Walker B; other site 272558010499 D-loop; other site 272558010500 H-loop/switch region; other site 272558010501 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272558010502 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 272558010503 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 272558010504 putative ligand binding site [chemical binding]; other site 272558010505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558010506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558010507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558010508 putative transposase OrfB; Reviewed; Region: PHA02517 272558010509 HTH-like domain; Region: HTH_21; pfam13276 272558010510 Integrase core domain; Region: rve; pfam00665 272558010511 Integrase core domain; Region: rve_3; pfam13683 272558010512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272558010513 Transposase; Region: HTH_Tnp_1; cl17663 272558010514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558010515 active site 272558010516 phosphorylation site [posttranslational modification] 272558010517 intermolecular recognition site; other site 272558010518 dimerization interface [polypeptide binding]; other site 272558010519 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558010520 Cache domain; Region: Cache_1; pfam02743 272558010521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558010522 dimerization interface [polypeptide binding]; other site 272558010523 Histidine kinase; Region: His_kinase; pfam06580 272558010524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558010525 ATP binding site [chemical binding]; other site 272558010526 Mg2+ binding site [ion binding]; other site 272558010527 G-X-G motif; other site 272558010528 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272558010529 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272558010530 ligand binding site [chemical binding]; other site 272558010531 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 272558010532 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272558010533 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272558010534 folate binding site [chemical binding]; other site 272558010535 NADP+ binding site [chemical binding]; other site 272558010536 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272558010537 dimerization interface [polypeptide binding]; other site 272558010538 active site 272558010539 Uncharacterized conserved protein [Function unknown]; Region: COG3377 272558010540 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272558010541 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272558010542 active site 272558010543 metal binding site [ion binding]; metal-binding site 272558010544 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272558010545 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272558010546 Uncharacterized conserved protein [Function unknown]; Region: COG1801 272558010547 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272558010548 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558010549 DNA binding residues [nucleotide binding] 272558010550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558010551 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558010552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558010553 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558010554 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558010555 Helix-turn-helix domain; Region: HTH_17; cl17695 272558010556 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272558010557 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558010558 FeS assembly protein SufB; Region: sufB; TIGR01980 272558010559 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272558010560 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272558010561 trimerization site [polypeptide binding]; other site 272558010562 active site 272558010563 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272558010564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558010565 catalytic residue [active] 272558010566 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272558010567 FeS assembly protein SufD; Region: sufD; TIGR01981 272558010568 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 272558010569 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272558010570 Walker A/P-loop; other site 272558010571 ATP binding site [chemical binding]; other site 272558010572 Q-loop/lid; other site 272558010573 ABC transporter signature motif; other site 272558010574 Walker B; other site 272558010575 D-loop; other site 272558010576 H-loop/switch region; other site 272558010577 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272558010578 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 272558010579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558010580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558010581 dimer interface [polypeptide binding]; other site 272558010582 phosphorylation site [posttranslational modification] 272558010583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558010584 ATP binding site [chemical binding]; other site 272558010585 Mg2+ binding site [ion binding]; other site 272558010586 G-X-G motif; other site 272558010587 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272558010588 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272558010589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558010590 dimer interface [polypeptide binding]; other site 272558010591 conserved gate region; other site 272558010592 putative PBP binding loops; other site 272558010593 ABC-ATPase subunit interface; other site 272558010594 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 272558010595 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272558010596 Walker A/P-loop; other site 272558010597 ATP binding site [chemical binding]; other site 272558010598 Q-loop/lid; other site 272558010599 ABC transporter signature motif; other site 272558010600 Walker B; other site 272558010601 D-loop; other site 272558010602 H-loop/switch region; other site 272558010603 NIL domain; Region: NIL; pfam09383 272558010604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558010605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272558010606 putative substrate translocation pore; other site 272558010607 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 272558010608 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272558010609 lipoyl attachment site [posttranslational modification]; other site 272558010610 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 272558010611 putative ArsC-like catalytic residues; other site 272558010612 putative TRX-like catalytic residues [active] 272558010613 Very long chain acyl-CoA dehydrogenase; Region: VLCAD; cd01161 272558010614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272558010615 FAD binding site [chemical binding]; other site 272558010616 substrate binding pocket [chemical binding]; other site 272558010617 catalytic base [active] 272558010618 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 272558010619 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272558010620 dimer interface [polypeptide binding]; other site 272558010621 active site 272558010622 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272558010623 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272558010624 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272558010625 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272558010626 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272558010627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558010628 substrate binding site [chemical binding]; other site 272558010629 oxyanion hole (OAH) forming residues; other site 272558010630 Coat F domain; Region: Coat_F; pfam07875 272558010631 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 272558010632 Predicted transcriptional regulators [Transcription]; Region: COG1725 272558010633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558010634 DNA-binding site [nucleotide binding]; DNA binding site 272558010635 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558010636 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558010637 Walker A/P-loop; other site 272558010638 ATP binding site [chemical binding]; other site 272558010639 Q-loop/lid; other site 272558010640 ABC transporter signature motif; other site 272558010641 Walker B; other site 272558010642 D-loop; other site 272558010643 H-loop/switch region; other site 272558010644 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272558010645 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558010646 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 272558010647 DNA binding residues [nucleotide binding] 272558010648 drug binding residues [chemical binding]; other site 272558010649 dimer interface [polypeptide binding]; other site 272558010650 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 272558010651 Putative zinc-finger; Region: zf-HC2; pfam13490 272558010652 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 272558010653 Uncharacterized conserved protein [Function unknown]; Region: COG0432 272558010654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558010655 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558010656 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558010657 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558010658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272558010659 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 272558010660 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 272558010661 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272558010662 Helix-turn-helix domain; Region: HTH_38; pfam13936 272558010663 Homeodomain-like domain; Region: HTH_32; pfam13565 272558010664 Integrase core domain; Region: rve; pfam00665 272558010665 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272558010666 FtsX-like permease family; Region: FtsX; pfam02687 272558010667 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558010668 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558010669 Walker A/P-loop; other site 272558010670 ATP binding site [chemical binding]; other site 272558010671 Q-loop/lid; other site 272558010672 ABC transporter signature motif; other site 272558010673 Walker B; other site 272558010674 D-loop; other site 272558010675 H-loop/switch region; other site 272558010676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558010677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558010678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558010679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558010680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558010681 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558010682 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558010683 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558010684 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272558010685 cofactor binding site; other site 272558010686 DNA binding site [nucleotide binding] 272558010687 substrate interaction site [chemical binding]; other site 272558010688 HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556 272558010689 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558010690 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558010691 active site 272558010692 metal binding site [ion binding]; metal-binding site 272558010693 Sporulation related domain; Region: SPOR; pfam05036 272558010694 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 272558010695 active site 272558010696 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 272558010697 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 272558010698 Phage-related protein [Function unknown]; Region: COG4722 272558010699 Phage-related protein [Function unknown]; Region: COG5412 272558010700 putative minor structural protein; Region: PHA01351 272558010701 putative minor structural protein; Region: PHA01351 272558010702 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 272558010703 Predicted secreted protein [Function unknown]; Region: COG5437 272558010704 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272558010705 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272558010706 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 272558010707 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 272558010708 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272558010709 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 272558010710 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 272558010711 active site 272558010712 conformational flexibility of ligand binding pocket; other site 272558010713 ADP-ribosylating toxin turn-turn motif; other site 272558010714 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 272558010715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 272558010716 Terminase-like family; Region: Terminase_6; pfam03237 272558010717 phage uncharacterized protein (putative large terminase), C-terminal domain; Region: psiM2_ORF9; TIGR01630 272558010718 Homeodomain-like domain; Region: HTH_23; pfam13384 272558010719 Transposase; Region: HTH_Tnp_1; cl17663 272558010720 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272558010721 ParB-like nuclease domain; Region: ParB; smart00470 272558010722 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272558010723 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 272558010724 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 272558010725 hypothetical protein; Provisional; Region: PRK06921 272558010726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558010727 Walker A motif; other site 272558010728 ATP binding site [chemical binding]; other site 272558010729 Walker B motif; other site 272558010730 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272558010731 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272558010732 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 272558010733 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 272558010734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 272558010735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558010736 non-specific DNA binding site [nucleotide binding]; other site 272558010737 salt bridge; other site 272558010738 sequence-specific DNA binding site [nucleotide binding]; other site 272558010739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272558010740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272558010741 non-specific DNA binding site [nucleotide binding]; other site 272558010742 salt bridge; other site 272558010743 sequence-specific DNA binding site [nucleotide binding]; other site 272558010744 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 272558010745 integrase; Provisional; Region: int; PHA02601 272558010746 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 272558010747 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272558010748 Int/Topo IB signature motif; other site 272558010749 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272558010750 SmpB-tmRNA interface; other site 272558010751 ribonuclease R; Region: RNase_R; TIGR02063 272558010752 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272558010753 RNB domain; Region: RNB; pfam00773 272558010754 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272558010755 RNA binding site [nucleotide binding]; other site 272558010756 Esterase/lipase [General function prediction only]; Region: COG1647 272558010757 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 272558010758 enolase; Provisional; Region: eno; PRK00077 272558010759 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272558010760 dimer interface [polypeptide binding]; other site 272558010761 metal binding site [ion binding]; metal-binding site 272558010762 substrate binding pocket [chemical binding]; other site 272558010763 phosphoglyceromutase; Provisional; Region: PRK05434 272558010764 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272558010765 substrate binding site [chemical binding]; other site 272558010766 dimer interface [polypeptide binding]; other site 272558010767 catalytic triad [active] 272558010768 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272558010769 substrate binding site [chemical binding]; other site 272558010770 hinge regions; other site 272558010771 ADP binding site [chemical binding]; other site 272558010772 catalytic site [active] 272558010773 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272558010774 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272558010775 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272558010776 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272558010777 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272558010778 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 272558010779 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 272558010780 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272558010781 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272558010782 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272558010783 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272558010784 oligomer interface [polypeptide binding]; other site 272558010785 active site residues [active] 272558010786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558010787 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558010788 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558010789 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558010790 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272558010791 dimerization domain swap beta strand [polypeptide binding]; other site 272558010792 regulatory protein interface [polypeptide binding]; other site 272558010793 active site 272558010794 regulatory phosphorylation site [posttranslational modification]; other site 272558010795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272558010796 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 272558010797 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 272558010798 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272558010799 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 272558010800 phosphate binding site [ion binding]; other site 272558010801 dimer interface [polypeptide binding]; other site 272558010802 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 272558010803 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 272558010804 putative active site [active] 272558010805 nucleotide binding site [chemical binding]; other site 272558010806 nudix motif; other site 272558010807 putative metal binding site [ion binding]; other site 272558010808 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272558010809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558010810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558010811 TPR repeat; Region: TPR_11; pfam13414 272558010812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558010813 binding surface 272558010814 TPR motif; other site 272558010815 TPR repeat; Region: TPR_11; pfam13414 272558010816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558010817 binding surface 272558010818 TPR motif; other site 272558010819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558010820 binding surface 272558010821 TPR motif; other site 272558010822 Uncharacterized conserved protein [Function unknown]; Region: COG3589 272558010823 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272558010824 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 272558010825 active site turn [active] 272558010826 phosphorylation site [posttranslational modification] 272558010827 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272558010828 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 272558010829 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272558010830 putative active site [active] 272558010831 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272558010832 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272558010833 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272558010834 putative active site [active] 272558010835 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272558010836 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 272558010837 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272558010838 metal binding site [ion binding]; metal-binding site 272558010839 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272558010840 substrate binding site [chemical binding]; other site 272558010841 glutamase interaction surface [polypeptide binding]; other site 272558010842 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272558010843 catalytic residues [active] 272558010844 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 272558010845 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272558010846 putative active site [active] 272558010847 oxyanion strand; other site 272558010848 catalytic triad [active] 272558010849 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272558010850 putative active site pocket [active] 272558010851 4-fold oligomerization interface [polypeptide binding]; other site 272558010852 metal binding residues [ion binding]; metal-binding site 272558010853 3-fold/trimer interface [polypeptide binding]; other site 272558010854 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272558010855 histidinol dehydrogenase; Region: hisD; TIGR00069 272558010856 NAD binding site [chemical binding]; other site 272558010857 dimerization interface [polypeptide binding]; other site 272558010858 product binding site; other site 272558010859 substrate binding site [chemical binding]; other site 272558010860 zinc binding site [ion binding]; other site 272558010861 catalytic residues [active] 272558010862 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 272558010863 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 272558010864 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 272558010865 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272558010866 dimer interface [polypeptide binding]; other site 272558010867 motif 1; other site 272558010868 active site 272558010869 motif 2; other site 272558010870 motif 3; other site 272558010871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558010872 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558010873 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558010874 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272558010875 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272558010876 trimer interface [polypeptide binding]; other site 272558010877 active site 272558010878 substrate binding site [chemical binding]; other site 272558010879 CoA binding site [chemical binding]; other site 272558010880 pyrophosphatase PpaX; Provisional; Region: PRK13288 272558010881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558010882 active site 272558010883 motif I; other site 272558010884 motif II; other site 272558010885 Nucleoside recognition; Region: Gate; pfam07670 272558010886 Nucleoside recognition; Region: Gate; pfam07670 272558010887 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 272558010888 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272558010889 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272558010890 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272558010891 Hpr binding site; other site 272558010892 active site 272558010893 homohexamer subunit interaction site [polypeptide binding]; other site 272558010894 Predicted membrane protein [Function unknown]; Region: COG1950 272558010895 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272558010896 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272558010897 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 272558010898 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272558010899 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272558010900 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272558010901 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272558010902 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272558010903 excinuclease ABC subunit B; Provisional; Region: PRK05298 272558010904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558010905 ATP binding site [chemical binding]; other site 272558010906 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 272558010907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558010908 putative Mg++ binding site [ion binding]; other site 272558010909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558010910 nucleotide binding region [chemical binding]; other site 272558010911 ATP-binding site [chemical binding]; other site 272558010912 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272558010913 UvrB/uvrC motif; Region: UVR; pfam02151 272558010914 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 272558010915 active site 272558010916 catalytic site [active] 272558010917 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272558010918 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272558010919 protein binding site [polypeptide binding]; other site 272558010920 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272558010921 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272558010922 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272558010923 protein binding site [polypeptide binding]; other site 272558010924 Catalytic dyad [active] 272558010925 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558010926 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272558010927 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272558010928 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 272558010929 Peptidase family M23; Region: Peptidase_M23; pfam01551 272558010930 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272558010931 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272558010932 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 272558010933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558010934 Walker A/P-loop; other site 272558010935 ATP binding site [chemical binding]; other site 272558010936 Q-loop/lid; other site 272558010937 ABC transporter signature motif; other site 272558010938 Walker B; other site 272558010939 D-loop; other site 272558010940 H-loop/switch region; other site 272558010941 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272558010942 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272558010943 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272558010944 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272558010945 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558010946 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558010947 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272558010948 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272558010949 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 272558010950 RF-1 domain; Region: RF-1; pfam00472 272558010951 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272558010952 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272558010953 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272558010954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558010955 nucleotide binding region [chemical binding]; other site 272558010956 ATP-binding site [chemical binding]; other site 272558010957 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272558010958 SEC-C motif; Region: SEC-C; pfam02810 272558010959 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272558010960 30S subunit binding site; other site 272558010961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558010962 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272558010963 DNA-binding site [nucleotide binding]; DNA binding site 272558010964 RNA-binding motif; other site 272558010965 Flagellar protein FliT; Region: FliT; pfam05400 272558010966 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 272558010967 flagellar capping protein; Validated; Region: fliD; PRK07737 272558010968 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 272558010969 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 272558010970 flagellar protein FlaG; Provisional; Region: PRK07738 272558010971 flagellin; Provisional; Region: PRK12804 272558010972 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272558010973 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272558010974 carbon storage regulator; Provisional; Region: PRK01712 272558010975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1699 272558010976 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 272558010977 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272558010978 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 272558010979 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272558010980 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272558010981 FlgN protein; Region: FlgN; pfam05130 272558010982 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 272558010983 flagellar operon protein TIGR03826; Region: YvyF 272558010984 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272558010985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558010986 active site 272558010987 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 272558010988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272558010989 ATP binding site [chemical binding]; other site 272558010990 putative Mg++ binding site [ion binding]; other site 272558010991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272558010992 nucleotide binding region [chemical binding]; other site 272558010993 ATP-binding site [chemical binding]; other site 272558010994 EDD domain protein, DegV family; Region: DegV; TIGR00762 272558010995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272558010996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558010997 active site 272558010998 phosphorylation site [posttranslational modification] 272558010999 intermolecular recognition site; other site 272558011000 dimerization interface [polypeptide binding]; other site 272558011001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272558011002 DNA binding residues [nucleotide binding] 272558011003 dimerization interface [polypeptide binding]; other site 272558011004 Sensor protein DegS; Region: DegS; pfam05384 272558011005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272558011006 Histidine kinase; Region: HisKA_3; pfam07730 272558011007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558011008 ATP binding site [chemical binding]; other site 272558011009 Mg2+ binding site [ion binding]; other site 272558011010 G-X-G motif; other site 272558011011 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 272558011012 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272558011013 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272558011014 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 272558011015 putative substrate binding pocket [chemical binding]; other site 272558011016 AC domain interface; other site 272558011017 catalytic triad [active] 272558011018 AB domain interface; other site 272558011019 interchain disulfide; other site 272558011020 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558011021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558011022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272558011023 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272558011024 SnoaL-like domain; Region: SnoaL_2; pfam12680 272558011025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558011026 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 272558011027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272558011030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558011031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558011032 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558011033 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272558011034 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558011035 peptide binding site [polypeptide binding]; other site 272558011036 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272558011037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011038 dimer interface [polypeptide binding]; other site 272558011039 conserved gate region; other site 272558011040 putative PBP binding loops; other site 272558011041 ABC-ATPase subunit interface; other site 272558011042 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272558011043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011044 dimer interface [polypeptide binding]; other site 272558011045 conserved gate region; other site 272558011046 putative PBP binding loops; other site 272558011047 ABC-ATPase subunit interface; other site 272558011048 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272558011049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558011050 Walker A/P-loop; other site 272558011051 ATP binding site [chemical binding]; other site 272558011052 Q-loop/lid; other site 272558011053 ABC transporter signature motif; other site 272558011054 Walker B; other site 272558011055 D-loop; other site 272558011056 H-loop/switch region; other site 272558011057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558011058 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272558011059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558011060 Walker A/P-loop; other site 272558011061 ATP binding site [chemical binding]; other site 272558011062 Q-loop/lid; other site 272558011063 ABC transporter signature motif; other site 272558011064 Walker B; other site 272558011065 D-loop; other site 272558011066 H-loop/switch region; other site 272558011067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558011068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558011069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558011070 putative DNA binding site [nucleotide binding]; other site 272558011071 putative Zn2+ binding site [ion binding]; other site 272558011072 AsnC family; Region: AsnC_trans_reg; pfam01037 272558011073 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272558011074 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272558011075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011076 dimer interface [polypeptide binding]; other site 272558011077 conserved gate region; other site 272558011078 putative PBP binding loops; other site 272558011079 ABC-ATPase subunit interface; other site 272558011080 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272558011081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011082 dimer interface [polypeptide binding]; other site 272558011083 conserved gate region; other site 272558011084 putative PBP binding loops; other site 272558011085 ABC-ATPase subunit interface; other site 272558011086 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272558011087 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 272558011088 peptide binding site [polypeptide binding]; other site 272558011089 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 272558011090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558011091 Walker A/P-loop; other site 272558011092 ATP binding site [chemical binding]; other site 272558011093 Q-loop/lid; other site 272558011094 ABC transporter signature motif; other site 272558011095 Walker B; other site 272558011096 D-loop; other site 272558011097 H-loop/switch region; other site 272558011098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558011099 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272558011100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272558011101 Walker A/P-loop; other site 272558011102 ATP binding site [chemical binding]; other site 272558011103 Q-loop/lid; other site 272558011104 ABC transporter signature motif; other site 272558011105 Walker B; other site 272558011106 D-loop; other site 272558011107 H-loop/switch region; other site 272558011108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272558011109 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272558011110 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011111 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011113 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011114 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011115 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011116 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011117 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011118 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011119 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011120 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011121 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011122 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 272558011123 Stage II sporulation protein; Region: SpoIID; pfam08486 272558011124 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272558011125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558011126 NAD(P) binding site [chemical binding]; other site 272558011127 active site 272558011128 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272558011129 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 272558011130 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272558011131 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272558011132 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272558011133 active site 272558011134 tetramer interface; other site 272558011135 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 272558011136 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558011137 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 272558011138 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 272558011139 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558011140 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 272558011141 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 272558011142 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272558011143 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 272558011144 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 272558011145 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272558011146 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272558011147 active site 272558011148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558011149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272558011150 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272558011151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272558011152 active site 272558011153 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558011154 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 272558011155 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272558011156 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272558011157 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272558011158 Walker A/P-loop; other site 272558011159 ATP binding site [chemical binding]; other site 272558011160 Q-loop/lid; other site 272558011161 ABC transporter signature motif; other site 272558011162 Walker B; other site 272558011163 D-loop; other site 272558011164 H-loop/switch region; other site 272558011165 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272558011166 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272558011167 Walker A/P-loop; other site 272558011168 ATP binding site [chemical binding]; other site 272558011169 Q-loop/lid; other site 272558011170 ABC transporter signature motif; other site 272558011171 Walker B; other site 272558011172 D-loop; other site 272558011173 H-loop/switch region; other site 272558011174 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272558011175 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272558011176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272558011177 active site 272558011178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272558011179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558011180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558011181 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 272558011182 putative ADP-binding pocket [chemical binding]; other site 272558011183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272558011184 Transposase, Mutator family; Region: Transposase_mut; cl19537 272558011185 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011186 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011187 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011188 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011189 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011191 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011192 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272558011193 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272558011194 active site 272558011195 metal binding site [ion binding]; metal-binding site 272558011196 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272558011197 active site 272558011198 catalytic triad [active] 272558011199 oxyanion hole [active] 272558011200 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 272558011201 PHP domain; Region: PHP; pfam02811 272558011202 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272558011203 AAA domain; Region: AAA_31; pfam13614 272558011204 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 272558011205 Chain length determinant protein; Region: Wzz; pfam02706 272558011206 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272558011207 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272558011208 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011209 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011210 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272558011211 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011212 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272558011213 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272558011214 NlpC/P60 family; Region: NLPC_P60; pfam00877 272558011215 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 272558011216 Utp11 protein; Region: Utp11; cl02164 272558011217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558011218 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558011219 Walker A/P-loop; other site 272558011220 ATP binding site [chemical binding]; other site 272558011221 Q-loop/lid; other site 272558011222 ABC transporter signature motif; other site 272558011223 Walker B; other site 272558011224 D-loop; other site 272558011225 H-loop/switch region; other site 272558011226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272558011227 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272558011228 FtsX-like permease family; Region: FtsX; pfam02687 272558011229 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 272558011230 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558011231 DNA binding residues [nucleotide binding] 272558011232 putative dimer interface [polypeptide binding]; other site 272558011233 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 272558011234 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 272558011235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272558011236 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558011237 HAMP domain; Region: HAMP; pfam00672 272558011238 Histidine kinase; Region: His_kinase; pfam06580 272558011239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558011240 ATP binding site [chemical binding]; other site 272558011241 Mg2+ binding site [ion binding]; other site 272558011242 G-X-G motif; other site 272558011243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558011244 active site 272558011245 phosphorylation site [posttranslational modification] 272558011246 intermolecular recognition site; other site 272558011247 dimerization interface [polypeptide binding]; other site 272558011248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011249 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272558011250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011251 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558011252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558011253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011254 dimer interface [polypeptide binding]; other site 272558011255 putative PBP binding loops; other site 272558011256 ABC-ATPase subunit interface; other site 272558011257 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558011258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011259 dimer interface [polypeptide binding]; other site 272558011260 conserved gate region; other site 272558011261 putative PBP binding loops; other site 272558011262 ABC-ATPase subunit interface; other site 272558011263 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272558011264 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 272558011265 inhibitor binding site; inhibition site 272558011266 active site 272558011267 Predicted integral membrane protein [Function unknown]; Region: COG5578 272558011268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 272558011269 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272558011270 ATP-binding site [chemical binding]; other site 272558011271 Gluconate-6-phosphate binding site [chemical binding]; other site 272558011272 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272558011273 EamA-like transporter family; Region: EamA; cl17759 272558011274 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558011275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011276 dimer interface [polypeptide binding]; other site 272558011277 conserved gate region; other site 272558011278 putative PBP binding loops; other site 272558011279 ABC-ATPase subunit interface; other site 272558011280 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558011281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011282 dimer interface [polypeptide binding]; other site 272558011283 conserved gate region; other site 272558011284 putative PBP binding loops; other site 272558011285 ABC-ATPase subunit interface; other site 272558011286 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558011287 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558011288 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 272558011289 N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742 272558011290 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 272558011291 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558011292 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558011293 DNA binding site [nucleotide binding] 272558011294 domain linker motif; other site 272558011295 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272558011296 dimerization interface [polypeptide binding]; other site 272558011297 ligand binding site [chemical binding]; other site 272558011298 Predicted membrane protein [Function unknown]; Region: COG2311 272558011299 Protein of unknown function (DUF418); Region: DUF418; pfam04235 272558011300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558011301 TPR motif; other site 272558011302 binding surface 272558011303 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 272558011304 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 272558011305 carbohydrate binding site [chemical binding]; other site 272558011306 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 272558011307 carbohydrate binding site [chemical binding]; other site 272558011308 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 272558011309 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 272558011310 Ca binding site [ion binding]; other site 272558011311 active site 272558011312 catalytic site [active] 272558011313 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272558011314 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272558011315 active site 272558011316 catalytic site [active] 272558011317 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272558011318 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272558011319 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272558011320 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 272558011321 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272558011322 Helix-turn-helix domain; Region: HTH_18; pfam12833 272558011323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011324 Protein of unknown function, DUF600; Region: DUF600; pfam04634 272558011325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558011326 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558011327 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558011328 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558011329 LXG domain of WXG superfamily; Region: LXG; pfam04740 272558011330 Pre-toxin TG; Region: PT-TG; pfam14449 272558011331 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 272558011332 TPR repeat; Region: TPR_11; pfam13414 272558011333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272558011334 TPR motif; other site 272558011335 binding surface 272558011336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272558011337 Predicted integral membrane protein [Function unknown]; Region: COG5652 272558011338 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 272558011339 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 272558011340 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272558011341 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272558011342 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272558011343 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 272558011344 putative NAD(P) binding site [chemical binding]; other site 272558011345 active site 272558011346 putative substrate binding site [chemical binding]; other site 272558011347 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272558011348 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272558011349 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272558011350 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 272558011351 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272558011352 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 272558011353 putative ADP-binding pocket [chemical binding]; other site 272558011354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272558011355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272558011356 active site 272558011357 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272558011358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272558011359 active site 272558011360 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272558011361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558011362 NAD(P) binding site [chemical binding]; other site 272558011363 active site 272558011364 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 272558011365 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272558011366 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272558011367 active site 272558011368 tetramer interface; other site 272558011369 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 272558011370 CoA binding domain; Region: CoA_binding; cl17356 272558011371 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 272558011372 NAD(P) binding site [chemical binding]; other site 272558011373 homodimer interface [polypeptide binding]; other site 272558011374 substrate binding site [chemical binding]; other site 272558011375 active site 272558011376 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 272558011377 PemK-like protein; Region: PemK; cl00995 272558011378 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272558011379 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272558011380 active site 272558011381 intersubunit interface [polypeptide binding]; other site 272558011382 catalytic residue [active] 272558011383 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272558011384 substrate binding site [chemical binding]; other site 272558011385 ATP binding site [chemical binding]; other site 272558011386 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272558011387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558011388 dimerization interface [polypeptide binding]; other site 272558011389 putative Zn2+ binding site [ion binding]; other site 272558011390 putative DNA binding site [nucleotide binding]; other site 272558011391 Bacterial transcriptional regulator; Region: IclR; pfam01614 272558011392 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272558011393 nudix motif; other site 272558011394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272558011395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272558011396 DNA binding site [nucleotide binding] 272558011397 domain linker motif; other site 272558011398 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 272558011399 dimerization interface [polypeptide binding]; other site 272558011400 ligand binding site [chemical binding]; other site 272558011401 sodium binding site [ion binding]; other site 272558011402 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272558011403 substrate binding site [chemical binding]; other site 272558011404 dimer interface [polypeptide binding]; other site 272558011405 ATP binding site [chemical binding]; other site 272558011406 D-ribose pyranase; Provisional; Region: PRK11797 272558011407 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272558011408 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272558011409 Walker A/P-loop; other site 272558011410 ATP binding site [chemical binding]; other site 272558011411 Q-loop/lid; other site 272558011412 ABC transporter signature motif; other site 272558011413 Walker B; other site 272558011414 D-loop; other site 272558011415 H-loop/switch region; other site 272558011416 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272558011417 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272558011418 TM-ABC transporter signature motif; other site 272558011419 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272558011420 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 272558011421 ligand binding site [chemical binding]; other site 272558011422 dimerization interface [polypeptide binding]; other site 272558011423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558011424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558011425 WHG domain; Region: WHG; pfam13305 272558011426 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272558011427 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 272558011428 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 272558011429 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272558011430 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272558011431 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 272558011432 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272558011433 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272558011434 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 272558011435 rod shape-determining protein Mbl; Provisional; Region: PRK13928 272558011436 MreB and similar proteins; Region: MreB_like; cd10225 272558011437 nucleotide binding site [chemical binding]; other site 272558011438 Mg binding site [ion binding]; other site 272558011439 putative protofilament interaction site [polypeptide binding]; other site 272558011440 RodZ interaction site [polypeptide binding]; other site 272558011441 Stage III sporulation protein D; Region: SpoIIID; pfam12116 272558011442 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272558011443 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272558011444 active site 272558011445 catalytic site [active] 272558011446 substrate binding site [chemical binding]; other site 272558011447 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 272558011448 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272558011449 ligand binding site [chemical binding]; other site 272558011450 flexible hinge region; other site 272558011451 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272558011452 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 272558011453 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272558011454 metal binding triad; other site 272558011455 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 272558011456 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272558011457 Na binding site [ion binding]; other site 272558011458 Predicted membrane protein [Function unknown]; Region: COG4327 272558011459 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272558011460 Peptidase family M23; Region: Peptidase_M23; pfam01551 272558011461 VID27 cytoplasmic protein; Region: VID27; cl19884 272558011462 stage II sporulation protein D; Region: spore_II_D; TIGR02870 272558011463 Stage II sporulation protein; Region: SpoIID; pfam08486 272558011464 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272558011465 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272558011466 hinge; other site 272558011467 active site 272558011468 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 272558011469 Predicted membrane protein [Function unknown]; Region: COG4836 272558011470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272558011471 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 272558011472 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272558011473 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272558011474 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272558011475 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272558011476 gamma subunit interface [polypeptide binding]; other site 272558011477 epsilon subunit interface [polypeptide binding]; other site 272558011478 LBP interface [polypeptide binding]; other site 272558011479 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272558011480 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272558011481 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272558011482 alpha subunit interaction interface [polypeptide binding]; other site 272558011483 Walker A motif; other site 272558011484 ATP binding site [chemical binding]; other site 272558011485 Walker B motif; other site 272558011486 inhibitor binding site; inhibition site 272558011487 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272558011488 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272558011489 core domain interface [polypeptide binding]; other site 272558011490 delta subunit interface [polypeptide binding]; other site 272558011491 epsilon subunit interface [polypeptide binding]; other site 272558011492 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272558011493 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272558011494 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272558011495 beta subunit interaction interface [polypeptide binding]; other site 272558011496 Walker A motif; other site 272558011497 ATP binding site [chemical binding]; other site 272558011498 Walker B motif; other site 272558011499 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272558011500 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272558011501 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272558011502 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272558011503 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 272558011504 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272558011505 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 272558011506 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 272558011507 Subtilase family; Region: Peptidase_S8; pfam00082 272558011508 catalytic triad [active] 272558011509 putative active site [active] 272558011510 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 272558011511 PA/protease domain interface [polypeptide binding]; other site 272558011512 putative integrin binding motif; other site 272558011513 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 272558011514 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 272558011515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272558011516 active site 272558011517 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272558011518 dimer interface [polypeptide binding]; other site 272558011519 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272558011520 active site 272558011521 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272558011522 folate binding site [chemical binding]; other site 272558011523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4475 272558011524 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 272558011525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558011526 dimerization interface [polypeptide binding]; other site 272558011527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272558011528 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558011529 dimer interface [polypeptide binding]; other site 272558011530 putative CheW interface [polypeptide binding]; other site 272558011531 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272558011532 active site 272558011533 Predicted membrane protein [Function unknown]; Region: COG1971 272558011534 Domain of unknown function DUF; Region: DUF204; pfam02659 272558011535 Domain of unknown function DUF; Region: DUF204; pfam02659 272558011536 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272558011537 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272558011538 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 272558011539 stage II sporulation protein R; Region: spore_II_R; TIGR02837 272558011540 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272558011541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558011542 S-adenosylmethionine binding site [chemical binding]; other site 272558011543 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272558011544 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272558011545 RF-1 domain; Region: RF-1; pfam00472 272558011546 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272558011547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272558011548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272558011549 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272558011550 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272558011551 catalytic triad [active] 272558011552 conserved cis-peptide bond; other site 272558011553 thymidine kinase; Provisional; Region: PRK04296 272558011554 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272558011555 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272558011556 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272558011557 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272558011558 RNA binding site [nucleotide binding]; other site 272558011559 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272558011560 multimer interface [polypeptide binding]; other site 272558011561 Walker A motif; other site 272558011562 ATP binding site [chemical binding]; other site 272558011563 Walker B motif; other site 272558011564 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272558011565 putative active site [active] 272558011566 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272558011567 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272558011568 hinge; other site 272558011569 active site 272558011570 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 272558011571 active site 272558011572 intersubunit interactions; other site 272558011573 catalytic residue [active] 272558011574 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272558011575 intersubunit interface [polypeptide binding]; other site 272558011576 active site 272558011577 zinc binding site [ion binding]; other site 272558011578 Na+ binding site [ion binding]; other site 272558011579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558011580 active site 272558011581 phosphorylation site [posttranslational modification] 272558011582 intermolecular recognition site; other site 272558011583 dimerization interface [polypeptide binding]; other site 272558011584 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 272558011585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558011586 ABC-ATPase subunit interface; other site 272558011587 dimer interface [polypeptide binding]; other site 272558011588 putative PBP binding regions; other site 272558011589 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272558011590 ABC-ATPase subunit interface; other site 272558011591 dimer interface [polypeptide binding]; other site 272558011592 putative PBP binding regions; other site 272558011593 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272558011594 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272558011595 siderophore binding site; other site 272558011596 CTP synthetase; Validated; Region: pyrG; PRK05380 272558011597 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272558011598 Catalytic site [active] 272558011599 active site 272558011600 UTP binding site [chemical binding]; other site 272558011601 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272558011602 active site 272558011603 putative oxyanion hole; other site 272558011604 catalytic triad [active] 272558011605 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 272558011606 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272558011607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558011608 Zn2+ binding site [ion binding]; other site 272558011609 Mg2+ binding site [ion binding]; other site 272558011610 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272558011611 B12 binding site [chemical binding]; other site 272558011612 cobalt ligand [ion binding]; other site 272558011613 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 272558011614 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272558011615 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 272558011616 putative active site [active] 272558011617 putative substrate binding site [chemical binding]; other site 272558011618 putative coenzyme B12 binding site [chemical binding]; other site 272558011619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272558011620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272558011621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272558011622 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 272558011623 FAD binding site [chemical binding]; other site 272558011624 homotetramer interface [polypeptide binding]; other site 272558011625 substrate binding pocket [chemical binding]; other site 272558011626 catalytic base [active] 272558011627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272558011628 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 272558011629 FAD binding site [chemical binding]; other site 272558011630 homotetramer interface [polypeptide binding]; other site 272558011631 substrate binding pocket [chemical binding]; other site 272558011632 catalytic base [active] 272558011633 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 272558011634 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272558011635 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272558011636 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 272558011637 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272558011638 dimer interface [polypeptide binding]; other site 272558011639 active site 272558011640 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272558011641 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 272558011642 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272558011643 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272558011644 Cysteine-rich domain; Region: CCG; pfam02754 272558011645 Cysteine-rich domain; Region: CCG; pfam02754 272558011646 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272558011647 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272558011648 putative active site [active] 272558011649 catalytic site [active] 272558011650 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272558011651 putative active site [active] 272558011652 catalytic site [active] 272558011653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558011654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558011655 Coenzyme A binding pocket [chemical binding]; other site 272558011656 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272558011657 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558011658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317 272558011659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 272558011660 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 272558011661 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 272558011662 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272558011663 active site 272558011664 HIGH motif; other site 272558011665 KMSK motif region; other site 272558011666 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272558011667 tRNA binding surface [nucleotide binding]; other site 272558011668 anticodon binding site; other site 272558011669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 272558011670 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010 272558011671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558011672 S-adenosylmethionine binding site [chemical binding]; other site 272558011673 Transglycosylase; Region: Transgly; pfam00912 272558011674 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272558011675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272558011676 YwhD family; Region: YwhD; pfam08741 272558011677 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 272558011678 active site 1 [active] 272558011679 dimer interface [polypeptide binding]; other site 272558011680 hexamer interface [polypeptide binding]; other site 272558011681 active site 2 [active] 272558011682 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558011683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272558011684 putative Zn2+ binding site [ion binding]; other site 272558011685 putative DNA binding site [nucleotide binding]; other site 272558011686 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272558011687 MMPL family; Region: MMPL; cl14618 272558011688 MMPL family; Region: MMPL; cl14618 272558011689 Uncharacterized conserved protein [Function unknown]; Region: COG3465 272558011690 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272558011691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272558011692 Zn2+ binding site [ion binding]; other site 272558011693 Mg2+ binding site [ion binding]; other site 272558011694 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 272558011695 Amb_all domain; Region: Amb_all; smart00656 272558011696 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 272558011697 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272558011698 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272558011699 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272558011700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272558011701 substrate binding site [chemical binding]; other site 272558011702 oxyanion hole (OAH) forming residues; other site 272558011703 trimer interface [polypeptide binding]; other site 272558011704 putative heme peroxidase; Provisional; Region: PRK12276 272558011705 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 272558011706 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272558011707 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 272558011708 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 272558011709 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272558011710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558011711 Coenzyme A binding pocket [chemical binding]; other site 272558011712 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 272558011713 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 272558011714 putative active site [active] 272558011715 Zn binding site [ion binding]; other site 272558011716 hypothetical protein; Provisional; Region: PRK07740 272558011717 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 272558011718 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272558011719 active site 272558011720 catalytic site [active] 272558011721 substrate binding site [chemical binding]; other site 272558011722 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 272558011723 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272558011724 metal binding triad; other site 272558011725 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 272558011726 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272558011727 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 272558011728 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 272558011729 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272558011730 Putative ammonia monooxygenase; Region: AmoA; pfam05145 272558011731 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272558011732 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 272558011733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558011734 active site 272558011735 phosphorylation site [posttranslational modification] 272558011736 intermolecular recognition site; other site 272558011737 dimerization interface [polypeptide binding]; other site 272558011738 Transcriptional regulator; Region: CitT; pfam12431 272558011739 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 272558011740 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 272558011741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558011742 putative active site [active] 272558011743 heme pocket [chemical binding]; other site 272558011744 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 272558011745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558011746 ATP binding site [chemical binding]; other site 272558011747 Mg2+ binding site [ion binding]; other site 272558011748 G-X-G motif; other site 272558011749 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272558011750 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272558011751 ligand binding site [chemical binding]; other site 272558011752 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272558011753 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272558011754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558011755 dimerization interface [polypeptide binding]; other site 272558011756 Histidine kinase; Region: His_kinase; pfam06580 272558011757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558011758 ATP binding site [chemical binding]; other site 272558011759 Mg2+ binding site [ion binding]; other site 272558011760 G-X-G motif; other site 272558011761 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272558011762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558011763 active site 272558011764 phosphorylation site [posttranslational modification] 272558011765 intermolecular recognition site; other site 272558011766 dimerization interface [polypeptide binding]; other site 272558011767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272558011769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272558011770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272558011771 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272558011772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272558011773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272558011774 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272558011775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011776 dimer interface [polypeptide binding]; other site 272558011777 conserved gate region; other site 272558011778 putative PBP binding loops; other site 272558011779 ABC-ATPase subunit interface; other site 272558011780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272558011781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272558011782 dimer interface [polypeptide binding]; other site 272558011783 conserved gate region; other site 272558011784 putative PBP binding loops; other site 272558011785 ABC-ATPase subunit interface; other site 272558011786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272558011787 active site 272558011788 catalytic tetrad [active] 272558011789 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272558011790 ligand binding site [chemical binding]; other site 272558011791 active site 272558011792 UGI interface [polypeptide binding]; other site 272558011793 catalytic site [active] 272558011794 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272558011795 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272558011796 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272558011797 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272558011798 active site 272558011799 phosphorylation site [posttranslational modification] 272558011800 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272558011801 HTH domain; Region: HTH_11; pfam08279 272558011802 HTH domain; Region: HTH_11; pfam08279 272558011803 PRD domain; Region: PRD; pfam00874 272558011804 PRD domain; Region: PRD; pfam00874 272558011805 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272558011806 active site 272558011807 P-loop; other site 272558011808 phosphorylation site [posttranslational modification] 272558011809 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 272558011810 active site 272558011811 phosphorylation site [posttranslational modification] 272558011812 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 272558011813 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272558011814 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272558011815 active site 272558011816 P-loop; other site 272558011817 phosphorylation site [posttranslational modification] 272558011818 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272558011819 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272558011820 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558011821 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 272558011822 DNA binding residues [nucleotide binding] 272558011823 dimer interface [polypeptide binding]; other site 272558011824 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272558011825 dimer interface [polypeptide binding]; other site 272558011826 FMN binding site [chemical binding]; other site 272558011827 azoreductase; Provisional; Region: PRK13556 272558011828 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 272558011829 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 272558011830 PA/protease domain interface [polypeptide binding]; other site 272558011831 putative integrin binding motif; other site 272558011832 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 272558011833 metal binding site [ion binding]; metal-binding site 272558011834 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 272558011835 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272558011836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558011837 dimerization interface [polypeptide binding]; other site 272558011838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558011839 dimer interface [polypeptide binding]; other site 272558011840 putative CheW interface [polypeptide binding]; other site 272558011841 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 272558011842 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272558011843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272558011844 motif II; other site 272558011845 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 272558011846 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_7; cd06244 272558011847 putative active site [active] 272558011848 Zn binding site [ion binding]; other site 272558011849 Predicted permeases [General function prediction only]; Region: RarD; COG2962 272558011850 EamA-like transporter family; Region: EamA; pfam00892 272558011851 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272558011852 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272558011853 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272558011854 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272558011855 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272558011856 Ca binding site [ion binding]; other site 272558011857 active site 272558011858 catalytic site [active] 272558011859 Domain of unknown function (DUF897); Region: DUF897; pfam05982 272558011860 Uncharacterized conserved protein [Function unknown]; Region: COG5609 272558011861 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272558011862 FAD dependent oxidoreductase; Region: DAO; pfam01266 272558011863 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 272558011864 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 272558011865 [2Fe-2S] cluster binding site [ion binding]; other site 272558011866 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 272558011867 dimer interface [polypeptide binding]; other site 272558011868 putative metal binding site [ion binding]; other site 272558011869 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 272558011870 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272558011871 PYR/PP interface [polypeptide binding]; other site 272558011872 dimer interface [polypeptide binding]; other site 272558011873 TPP binding site [chemical binding]; other site 272558011874 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272558011875 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 272558011876 TPP-binding site [chemical binding]; other site 272558011877 Uncharacterized conserved protein [Function unknown]; Region: COG0011 272558011878 hypothetical protein; Provisional; Region: PRK08201 272558011879 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 272558011880 metal binding site [ion binding]; metal-binding site 272558011881 putative dimer interface [polypeptide binding]; other site 272558011882 hypothetical protein; Provisional; Region: PRK03057 272558011883 UPF0302 domain; Region: UPF0302; pfam08864 272558011884 IDEAL domain; Region: IDEAL; pfam08858 272558011885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272558011886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558011887 putative DNA binding site [nucleotide binding]; other site 272558011888 putative Zn2+ binding site [ion binding]; other site 272558011889 AsnC family; Region: AsnC_trans_reg; pfam01037 272558011890 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272558011891 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272558011892 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558011893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558011894 putative substrate translocation pore; other site 272558011895 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272558011896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272558011897 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272558011898 DNA binding residues [nucleotide binding] 272558011899 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272558011900 Predicted transcriptional regulators [Transcription]; Region: COG1733 272558011901 hypothetical protein; Provisional; Region: PRK09739 272558011902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272558011903 H+ Antiporter protein; Region: 2A0121; TIGR00900 272558011904 putative substrate translocation pore; other site 272558011905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558011906 putative DNA binding site [nucleotide binding]; other site 272558011907 dimerization interface [polypeptide binding]; other site 272558011908 putative Zn2+ binding site [ion binding]; other site 272558011909 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272558011910 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 272558011911 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272558011912 putative NAD(P) binding site [chemical binding]; other site 272558011913 putative active site [active] 272558011914 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272558011915 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 272558011916 putative ligand binding residues [chemical binding]; other site 272558011917 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272558011918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558011919 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272558011920 Walker A/P-loop; other site 272558011921 ATP binding site [chemical binding]; other site 272558011922 Q-loop/lid; other site 272558011923 ABC transporter signature motif; other site 272558011924 Walker B; other site 272558011925 D-loop; other site 272558011926 H-loop/switch region; other site 272558011927 Acyltransferase family; Region: Acyl_transf_3; cl19154 272558011928 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272558011929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272558011930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272558011931 Walker A/P-loop; other site 272558011932 ATP binding site [chemical binding]; other site 272558011933 Q-loop/lid; other site 272558011934 ABC transporter signature motif; other site 272558011935 Walker B; other site 272558011936 D-loop; other site 272558011937 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 272558011938 H-loop/switch region; other site 272558011939 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558011940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558011941 ATP binding site [chemical binding]; other site 272558011942 Q-loop/lid; other site 272558011943 ABC transporter signature motif; other site 272558011944 Walker B; other site 272558011945 D-loop; other site 272558011946 H-loop/switch region; other site 272558011947 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272558011948 LytTr DNA-binding domain; Region: LytTR; pfam04397 272558011949 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 272558011950 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272558011951 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272558011952 NAD(P) binding site [chemical binding]; other site 272558011953 homotetramer interface [polypeptide binding]; other site 272558011954 homodimer interface [polypeptide binding]; other site 272558011955 active site 272558011956 fructuronate transporter; Provisional; Region: PRK10034; cl15264 272558011957 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 272558011958 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 272558011959 Coenzyme A transferase; Region: CoA_trans; smart00882 272558011960 Coenzyme A transferase; Region: CoA_trans; cl17247 272558011961 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 272558011962 PAS domain; Region: PAS; smart00091 272558011963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558011964 putative active site [active] 272558011965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558011966 Walker A motif; other site 272558011967 ATP binding site [chemical binding]; other site 272558011968 Walker B motif; other site 272558011969 arginine finger; other site 272558011970 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558011971 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 272558011972 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272558011973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558011974 dimerization interface [polypeptide binding]; other site 272558011975 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558011976 dimer interface [polypeptide binding]; other site 272558011977 putative CheW interface [polypeptide binding]; other site 272558011978 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272558011979 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 272558011980 putative ligand binding site [chemical binding]; other site 272558011981 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 272558011982 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272558011983 NodB motif; other site 272558011984 active site 272558011985 catalytic site [active] 272558011986 Zn binding site [ion binding]; other site 272558011987 Cache domain; Region: Cache_1; pfam02743 272558011988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558011989 dimerization interface [polypeptide binding]; other site 272558011990 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558011991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558011992 dimer interface [polypeptide binding]; other site 272558011993 putative CheW interface [polypeptide binding]; other site 272558011994 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 272558011995 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 272558011996 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 272558011997 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272558011998 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272558011999 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272558012000 substrate-cofactor binding pocket; other site 272558012001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558012002 catalytic residue [active] 272558012003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272558012004 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558012005 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 272558012006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558012007 S-adenosylmethionine binding site [chemical binding]; other site 272558012008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558012009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558012010 active site 272558012011 phosphorylation site [posttranslational modification] 272558012012 intermolecular recognition site; other site 272558012013 dimerization interface [polypeptide binding]; other site 272558012014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558012015 DNA binding site [nucleotide binding] 272558012016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272558012017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558012018 dimer interface [polypeptide binding]; other site 272558012019 phosphorylation site [posttranslational modification] 272558012020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558012021 ATP binding site [chemical binding]; other site 272558012022 Mg2+ binding site [ion binding]; other site 272558012023 G-X-G motif; other site 272558012024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272558012025 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272558012026 Walker A/P-loop; other site 272558012027 ATP binding site [chemical binding]; other site 272558012028 Q-loop/lid; other site 272558012029 ABC transporter signature motif; other site 272558012030 Walker B; other site 272558012031 D-loop; other site 272558012032 H-loop/switch region; other site 272558012033 FtsX-like permease family; Region: FtsX; pfam02687 272558012034 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 272558012035 Cache domain; Region: Cache_1; pfam02743 272558012036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558012037 dimerization interface [polypeptide binding]; other site 272558012038 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272558012039 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272558012040 dimer interface [polypeptide binding]; other site 272558012041 putative CheW interface [polypeptide binding]; other site 272558012042 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272558012043 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 272558012044 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272558012045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272558012046 DNA-binding site [nucleotide binding]; DNA binding site 272558012047 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272558012048 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272558012049 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272558012050 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 272558012051 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272558012052 active site 272558012053 methionine cluster; other site 272558012054 phosphorylation site [posttranslational modification] 272558012055 metal binding site [ion binding]; metal-binding site 272558012056 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272558012057 active site 272558012058 P-loop; other site 272558012059 phosphorylation site [posttranslational modification] 272558012060 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272558012061 tetramer interface [polypeptide binding]; other site 272558012062 active site 272558012063 Mg2+/Mn2+ binding site [ion binding]; other site 272558012064 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 272558012065 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272558012066 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 272558012067 dimer interface [polypeptide binding]; other site 272558012068 active site 272558012069 coenzyme A binding site [chemical binding]; other site 272558012070 citrylCoA binding site [chemical binding]; other site 272558012071 oxalacetate/citrate binding site [chemical binding]; other site 272558012072 catalytic triad [active] 272558012073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272558012074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272558012075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272558012076 dimerization interface [polypeptide binding]; other site 272558012077 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272558012078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272558012079 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272558012080 active site 272558012081 catalytic tetrad [active] 272558012082 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272558012083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272558012084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272558012085 Coenzyme A binding pocket [chemical binding]; other site 272558012086 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 272558012087 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 272558012088 active site 272558012089 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558012090 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272558012091 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 272558012092 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 272558012093 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272558012094 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272558012095 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272558012096 NAD binding site [chemical binding]; other site 272558012097 dimer interface [polypeptide binding]; other site 272558012098 substrate binding site [chemical binding]; other site 272558012099 hypothetical protein; Validated; Region: PRK00029 272558012100 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 272558012101 Glutamate binding site [chemical binding]; other site 272558012102 homodimer interface [polypeptide binding]; other site 272558012103 NAD binding site [chemical binding]; other site 272558012104 catalytic residues [active] 272558012105 hypothetical protein; Validated; Region: PRK06748 272558012106 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272558012107 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272558012108 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272558012109 NAD(P) binding site [chemical binding]; other site 272558012110 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272558012111 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272558012112 inhibitor-cofactor binding pocket; inhibition site 272558012113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272558012114 catalytic residue [active] 272558012115 PAS domain; Region: PAS; smart00091 272558012116 PAS domain; Region: PAS_9; pfam13426 272558012117 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 272558012118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558012119 Walker A motif; other site 272558012120 ATP binding site [chemical binding]; other site 272558012121 Walker B motif; other site 272558012122 arginine finger; other site 272558012123 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272558012124 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 272558012125 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272558012126 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272558012127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 272558012128 Nucleoside recognition; Region: Gate; pfam07670 272558012129 Arginase family; Region: Arginase; cd09989 272558012130 active site 272558012131 Mn binding site [ion binding]; other site 272558012132 oligomer interface [polypeptide binding]; other site 272558012133 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272558012134 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 272558012135 putative NAD(P) binding site [chemical binding]; other site 272558012136 catalytic Zn binding site [ion binding]; other site 272558012137 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272558012138 Helix-turn-helix domain; Region: HTH_38; pfam13936 272558012139 Homeodomain-like domain; Region: HTH_32; pfam13565 272558012140 Integrase core domain; Region: rve; pfam00665 272558012141 Predicted transcriptional regulators [Transcription]; Region: COG1695 272558012142 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272558012143 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 272558012144 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272558012145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558012146 S-adenosylmethionine binding site [chemical binding]; other site 272558012147 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272558012148 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 272558012149 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272558012150 NAD(P) binding pocket [chemical binding]; other site 272558012151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272558012152 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 272558012153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 272558012154 dimer interface [polypeptide binding]; other site 272558012155 active site 272558012156 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272558012157 catalytic residues [active] 272558012158 substrate binding site [chemical binding]; other site 272558012159 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 272558012160 malate:quinone oxidoreductase; Validated; Region: PRK05257 272558012161 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272558012162 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272558012163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272558012164 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 272558012165 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 272558012166 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 272558012167 active site 272558012168 catalytic triad [active] 272558012169 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272558012170 Interdomain contacts; other site 272558012171 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 272558012172 Cytokine receptor motif; other site 272558012173 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 272558012174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272558012175 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 272558012176 DNA-binding interface [nucleotide binding]; DNA binding site 272558012177 Integrase core domain; Region: rve; pfam00665 272558012178 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272558012179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558012180 Walker A motif; other site 272558012181 ATP binding site [chemical binding]; other site 272558012182 Walker B motif; other site 272558012183 arginine finger; other site 272558012184 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272558012185 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 272558012186 transglutaminase; Provisional; Region: tgl; PRK03187 272558012187 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272558012188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558012189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558012190 Walker A/P-loop; other site 272558012191 ATP binding site [chemical binding]; other site 272558012192 Q-loop/lid; other site 272558012193 ABC transporter signature motif; other site 272558012194 Walker B; other site 272558012195 D-loop; other site 272558012196 H-loop/switch region; other site 272558012197 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 272558012198 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272558012199 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272558012200 Walker A/P-loop; other site 272558012201 ATP binding site [chemical binding]; other site 272558012202 Q-loop/lid; other site 272558012203 ABC transporter signature motif; other site 272558012204 Walker B; other site 272558012205 D-loop; other site 272558012206 H-loop/switch region; other site 272558012207 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 272558012208 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 272558012209 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272558012210 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272558012211 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272558012212 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272558012213 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272558012214 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 272558012215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272558012216 Walker A/P-loop; other site 272558012217 ATP binding site [chemical binding]; other site 272558012218 Q-loop/lid; other site 272558012219 ABC transporter signature motif; other site 272558012220 Walker B; other site 272558012221 D-loop; other site 272558012222 H-loop/switch region; other site 272558012223 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272558012224 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272558012225 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272558012226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272558012227 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272558012228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558012229 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558012230 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558012231 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 272558012232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272558012233 DinB family; Region: DinB; cl17821 272558012234 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558012235 Pre-toxin TG; Region: PT-TG; pfam14449 272558012236 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558012237 LXG domain of WXG superfamily; Region: LXG; pfam04740 272558012238 Predicted transcriptional regulator [Transcription]; Region: COG3655 272558012239 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 272558012240 GIY-YIG motif/motif A; other site 272558012241 putative active site [active] 272558012242 putative metal binding site [ion binding]; other site 272558012243 Uncharacterized conserved protein [Function unknown]; Region: COG3410 272558012244 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 272558012245 homodimer interface [polypeptide binding]; other site 272558012246 chemical substrate binding site [chemical binding]; other site 272558012247 oligomer interface [polypeptide binding]; other site 272558012248 metal binding site [ion binding]; metal-binding site 272558012249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272558012250 Integrase core domain; Region: rve; pfam00665 272558012251 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272558012252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558012253 Walker A motif; other site 272558012254 ATP binding site [chemical binding]; other site 272558012255 Walker B motif; other site 272558012256 arginine finger; other site 272558012257 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272558012258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272558012259 Walker A motif; other site 272558012260 ATP binding site [chemical binding]; other site 272558012261 Walker B motif; other site 272558012262 arginine finger; other site 272558012263 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 272558012264 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272558012265 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 272558012266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272558012267 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272558012268 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272558012269 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 272558012270 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 272558012271 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 272558012272 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 272558012273 active site 272558012274 catalytic site [active] 272558012275 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 272558012276 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 272558012277 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272558012278 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272558012279 LXG domain of WXG superfamily; Region: LXG; pfam04740 272558012280 FOG: WD40-like repeat [Function unknown]; Region: COG1520 272558012281 serine endoprotease; Provisional; Region: PRK10898 272558012282 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272558012283 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272558012284 protein binding site [polypeptide binding]; other site 272558012285 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272558012286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 272558012287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 272558012288 YycH protein; Region: YycH; pfam07435 272558012289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272558012290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272558012291 dimerization interface [polypeptide binding]; other site 272558012292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272558012293 putative active site [active] 272558012294 heme pocket [chemical binding]; other site 272558012295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272558012296 dimer interface [polypeptide binding]; other site 272558012297 phosphorylation site [posttranslational modification] 272558012298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272558012299 ATP binding site [chemical binding]; other site 272558012300 Mg2+ binding site [ion binding]; other site 272558012301 G-X-G motif; other site 272558012302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272558012303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272558012304 active site 272558012305 phosphorylation site [posttranslational modification] 272558012306 intermolecular recognition site; other site 272558012307 dimerization interface [polypeptide binding]; other site 272558012308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272558012309 DNA binding site [nucleotide binding] 272558012310 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272558012311 GDP-binding site [chemical binding]; other site 272558012312 ACT binding site; other site 272558012313 IMP binding site; other site 272558012314 replicative DNA helicase; Provisional; Region: PRK05748 272558012315 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272558012316 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272558012317 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272558012318 Walker A motif; other site 272558012319 ATP binding site [chemical binding]; other site 272558012320 Walker B motif; other site 272558012321 DNA binding loops [nucleotide binding] 272558012322 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272558012323 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272558012324 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272558012325 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272558012326 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272558012327 DHH family; Region: DHH; pfam01368 272558012328 DHHA1 domain; Region: DHHA1; pfam02272 272558012329 Predicted membrane protein [Function unknown]; Region: COG4241 272558012330 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272558012331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272558012332 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272558012333 metal-binding site [ion binding] 272558012334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272558012335 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272558012336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272558012337 dimerization interface [polypeptide binding]; other site 272558012338 putative DNA binding site [nucleotide binding]; other site 272558012339 putative Zn2+ binding site [ion binding]; other site 272558012340 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 272558012341 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272558012342 TrkA-C domain; Region: TrkA_C; pfam02080 272558012343 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 272558012344 Int/Topo IB signature motif; other site 272558012345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272558012346 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272558012347 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272558012348 azoreductase; Reviewed; Region: PRK00170 272558012349 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272558012350 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272558012351 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272558012352 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272558012353 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272558012354 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272558012355 DNA binding residues [nucleotide binding] 272558012356 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 272558012357 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272558012358 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272558012359 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272558012360 dimer interface [polypeptide binding]; other site 272558012361 ssDNA binding site [nucleotide binding]; other site 272558012362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272558012363 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272558012364 GTP-binding protein YchF; Reviewed; Region: PRK09601 272558012365 YchF GTPase; Region: YchF; cd01900 272558012366 G1 box; other site 272558012367 GTP/Mg2+ binding site [chemical binding]; other site 272558012368 Switch I region; other site 272558012369 G2 box; other site 272558012370 Switch II region; other site 272558012371 G3 box; other site 272558012372 G4 box; other site 272558012373 G5 box; other site 272558012374 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272558012375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 272558012376 Uncharacterized membrane protein [Function unknown]; Region: COG3949 272558012377 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 272558012378 Protein of unknown function (DUF554); Region: DUF554; pfam04474 272558012379 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272558012380 cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977 272558012381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272558012382 catalytic residue [active] 272558012383 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272558012384 ParB-like nuclease domain; Region: ParBc; pfam02195 272558012385 KorB domain; Region: KorB; pfam08535 272558012386 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272558012387 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272558012388 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272558012389 P-loop; other site 272558012390 Magnesium ion binding site [ion binding]; other site 272558012391 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 272558012392 ParB-like nuclease domain; Region: ParB; smart00470 272558012393 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272558012394 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272558012395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272558012396 S-adenosylmethionine binding site [chemical binding]; other site 272558012397 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272558012398 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 272558012399 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272558012400 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272558012401 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272558012402 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272558012403 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272558012404 G1 box; other site 272558012405 GTP/Mg2+ binding site [chemical binding]; other site 272558012406 Switch I region; other site 272558012407 G2 box; other site 272558012408 Switch II region; other site 272558012409 G3 box; other site 272558012410 G4 box; other site 272558012411 G5 box; other site 272558012412 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272558012413 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272558012414 Jag N-terminus; Region: Jag_N; pfam14804 272558012415 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272558012416 G-X-X-G motif; other site 272558012417 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272558012418 RxxxH motif; other site 272558012419 OxaA-like protein precursor; Validated; Region: PRK02944 272558012420 ribonuclease P; Reviewed; Region: rnpA; PRK00499 272558012421 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399