-- dump date 20140618_222801 -- class Genbank::misc_feature -- table misc_feature_note -- id note 766760000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 766760000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 766760000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760000004 Walker A motif; other site 766760000005 ATP binding site [chemical binding]; other site 766760000006 Walker B motif; other site 766760000007 arginine finger; other site 766760000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 766760000009 DnaA box-binding interface [nucleotide binding]; other site 766760000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 766760000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 766760000012 putative DNA binding surface [nucleotide binding]; other site 766760000013 dimer interface [polypeptide binding]; other site 766760000014 beta-clamp/clamp loader binding surface; other site 766760000015 beta-clamp/translesion DNA polymerase binding surface; other site 766760000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 766760000017 recombination protein F; Reviewed; Region: recF; PRK00064 766760000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 766760000019 Walker A/P-loop; other site 766760000020 ATP binding site [chemical binding]; other site 766760000021 Q-loop/lid; other site 766760000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760000023 ABC transporter signature motif; other site 766760000024 Walker B; other site 766760000025 D-loop; other site 766760000026 H-loop/switch region; other site 766760000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 766760000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760000029 ATP binding site [chemical binding]; other site 766760000030 Mg2+ binding site [ion binding]; other site 766760000031 G-X-G motif; other site 766760000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 766760000033 anchoring element; other site 766760000034 dimer interface [polypeptide binding]; other site 766760000035 ATP binding site [chemical binding]; other site 766760000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 766760000037 active site 766760000038 putative metal-binding site [ion binding]; other site 766760000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 766760000040 DNA gyrase subunit A; Validated; Region: PRK05560 766760000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 766760000042 CAP-like domain; other site 766760000043 active site 766760000044 primary dimer interface [polypeptide binding]; other site 766760000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760000051 YaaC-like Protein; Region: YaaC; pfam14175 766760000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 766760000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 766760000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 766760000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 766760000056 active site 766760000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 766760000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 766760000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 766760000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 766760000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 766760000062 active site 766760000063 multimer interface [polypeptide binding]; other site 766760000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 766760000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 766760000066 predicted active site [active] 766760000067 catalytic triad [active] 766760000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 766760000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 766760000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 766760000071 dimer interface [polypeptide binding]; other site 766760000072 active site 766760000073 motif 1; other site 766760000074 motif 2; other site 766760000075 motif 3; other site 766760000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 766760000077 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 766760000078 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 766760000079 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 766760000080 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 766760000081 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 766760000082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 766760000083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 766760000084 Substrate-binding site [chemical binding]; other site 766760000085 Substrate specificity [chemical binding]; other site 766760000086 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 766760000087 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 766760000088 Substrate-binding site [chemical binding]; other site 766760000089 Substrate specificity [chemical binding]; other site 766760000090 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 766760000091 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760000092 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760000093 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 766760000094 active site 766760000095 Isochorismatase family; Region: Isochorismatase; pfam00857 766760000096 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 766760000097 catalytic triad [active] 766760000098 conserved cis-peptide bond; other site 766760000099 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 766760000100 nucleoside/Zn binding site; other site 766760000101 dimer interface [polypeptide binding]; other site 766760000102 catalytic motif [active] 766760000103 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 766760000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760000105 Walker A motif; other site 766760000106 ATP binding site [chemical binding]; other site 766760000107 Walker B motif; other site 766760000108 arginine finger; other site 766760000109 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 766760000110 hypothetical protein; Validated; Region: PRK00153 766760000111 recombination protein RecR; Reviewed; Region: recR; PRK00076 766760000112 RecR protein; Region: RecR; pfam02132 766760000113 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 766760000114 putative active site [active] 766760000115 putative metal-binding site [ion binding]; other site 766760000116 tetramer interface [polypeptide binding]; other site 766760000117 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 766760000118 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 766760000119 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 766760000120 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 766760000121 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 766760000122 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 766760000123 homodimer interface [polypeptide binding]; other site 766760000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760000125 catalytic residue [active] 766760000126 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 766760000127 thymidylate kinase; Validated; Region: tmk; PRK00698 766760000128 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 766760000129 TMP-binding site; other site 766760000130 ATP-binding site [chemical binding]; other site 766760000131 Protein of unknown function (DUF970); Region: DUF970; pfam06153 766760000132 Protein of unknown function (DUF327); Region: DUF327; pfam03885 766760000133 DNA polymerase III subunit delta'; Validated; Region: PRK08058 766760000134 DNA polymerase III subunit delta'; Validated; Region: PRK08485 766760000135 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 766760000136 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 766760000137 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 766760000138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760000139 S-adenosylmethionine binding site [chemical binding]; other site 766760000140 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 766760000141 GIY-YIG motif/motif A; other site 766760000142 putative active site [active] 766760000143 putative metal binding site [ion binding]; other site 766760000144 Predicted methyltransferases [General function prediction only]; Region: COG0313 766760000145 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 766760000146 putative SAM binding site [chemical binding]; other site 766760000147 putative homodimer interface [polypeptide binding]; other site 766760000148 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 766760000149 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 766760000150 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 766760000151 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 766760000152 active site 766760000153 HIGH motif; other site 766760000154 KMSKS motif; other site 766760000155 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 766760000156 tRNA binding surface [nucleotide binding]; other site 766760000157 anticodon binding site; other site 766760000158 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 766760000159 dimer interface [polypeptide binding]; other site 766760000160 putative tRNA-binding site [nucleotide binding]; other site 766760000161 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 766760000162 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 766760000163 active site 766760000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 766760000165 Domain of unknown function (DUF348); Region: DUF348; pfam03990 766760000166 Domain of unknown function (DUF348); Region: DUF348; pfam03990 766760000167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 766760000168 G5 domain; Region: G5; pfam07501 766760000169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 766760000170 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 766760000171 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 766760000172 putative active site [active] 766760000173 putative metal binding site [ion binding]; other site 766760000174 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 766760000175 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 766760000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760000177 S-adenosylmethionine binding site [chemical binding]; other site 766760000178 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 766760000179 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 766760000180 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 766760000181 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 766760000182 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 766760000183 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 766760000184 pur operon repressor; Provisional; Region: PRK09213 766760000185 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 766760000186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760000187 active site 766760000188 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 766760000189 homotrimer interaction site [polypeptide binding]; other site 766760000190 putative active site [active] 766760000191 regulatory protein SpoVG; Reviewed; Region: PRK13259 766760000192 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 766760000193 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 766760000194 Substrate binding site; other site 766760000195 Mg++ binding site; other site 766760000196 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 766760000197 active site 766760000198 substrate binding site [chemical binding]; other site 766760000199 CoA binding site [chemical binding]; other site 766760000200 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 766760000201 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 766760000202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760000203 active site 766760000204 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 766760000205 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 766760000206 5S rRNA interface [nucleotide binding]; other site 766760000207 CTC domain interface [polypeptide binding]; other site 766760000208 L16 interface [polypeptide binding]; other site 766760000209 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 766760000210 putative active site [active] 766760000211 catalytic residue [active] 766760000212 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 766760000213 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 766760000214 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 766760000215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760000216 ATP binding site [chemical binding]; other site 766760000217 putative Mg++ binding site [ion binding]; other site 766760000218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760000219 nucleotide binding region [chemical binding]; other site 766760000220 ATP-binding site [chemical binding]; other site 766760000221 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 766760000222 stage V sporulation protein T; Region: spore_V_T; TIGR02851 766760000223 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 766760000224 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 766760000225 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 766760000226 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 766760000227 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 766760000228 putative SAM binding site [chemical binding]; other site 766760000229 putative homodimer interface [polypeptide binding]; other site 766760000230 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 766760000231 homodimer interface [polypeptide binding]; other site 766760000232 metal binding site [ion binding]; metal-binding site 766760000233 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 766760000234 homodimer interface [polypeptide binding]; other site 766760000235 active site 766760000236 putative chemical substrate binding site [chemical binding]; other site 766760000237 metal binding site [ion binding]; metal-binding site 766760000238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760000239 RNA binding surface [nucleotide binding]; other site 766760000240 sporulation protein YabP; Region: spore_yabP; TIGR02892 766760000241 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 766760000242 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 766760000243 Septum formation initiator; Region: DivIC; pfam04977 766760000244 hypothetical protein; Provisional; Region: PRK08582 766760000245 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 766760000246 RNA binding site [nucleotide binding]; other site 766760000247 stage II sporulation protein E; Region: spore_II_E; TIGR02865 766760000248 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 766760000249 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 766760000250 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 766760000251 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 766760000252 metal ion-dependent adhesion site (MIDAS); other site 766760000253 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 766760000254 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 766760000255 active site 766760000256 ATP binding site [chemical binding]; other site 766760000257 substrate binding site [chemical binding]; other site 766760000258 activation loop (A-loop); other site 766760000259 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 766760000260 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 766760000261 Ligand Binding Site [chemical binding]; other site 766760000262 TilS substrate binding domain; Region: TilS; pfam09179 766760000263 TilS substrate C-terminal domain; Region: TilS_C; smart00977 766760000264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760000265 active site 766760000266 FtsH Extracellular; Region: FtsH_ext; pfam06480 766760000267 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 766760000268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760000269 Walker A motif; other site 766760000270 ATP binding site [chemical binding]; other site 766760000271 Walker B motif; other site 766760000272 arginine finger; other site 766760000273 Peptidase family M41; Region: Peptidase_M41; pfam01434 766760000274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 766760000275 nucleotide binding site [chemical binding]; other site 766760000276 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 766760000277 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 766760000278 dimerization interface [polypeptide binding]; other site 766760000279 domain crossover interface; other site 766760000280 redox-dependent activation switch; other site 766760000281 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 766760000282 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 766760000283 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 766760000284 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 766760000285 dimer interface [polypeptide binding]; other site 766760000286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760000287 catalytic residue [active] 766760000288 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 766760000289 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 766760000290 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 766760000291 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 766760000292 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 766760000293 glutamine binding [chemical binding]; other site 766760000294 catalytic triad [active] 766760000295 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 766760000296 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 766760000297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760000298 catalytic residue [active] 766760000299 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 766760000300 dihydropteroate synthase; Region: DHPS; TIGR01496 766760000301 substrate binding pocket [chemical binding]; other site 766760000302 dimer interface [polypeptide binding]; other site 766760000303 inhibitor binding site; inhibition site 766760000304 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 766760000305 homooctamer interface [polypeptide binding]; other site 766760000306 active site 766760000307 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 766760000308 catalytic center binding site [active] 766760000309 ATP binding site [chemical binding]; other site 766760000310 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 766760000311 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 766760000312 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 766760000313 FMN binding site [chemical binding]; other site 766760000314 active site 766760000315 catalytic residues [active] 766760000316 substrate binding site [chemical binding]; other site 766760000317 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 766760000318 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 766760000319 dimer interface [polypeptide binding]; other site 766760000320 putative anticodon binding site; other site 766760000321 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 766760000322 motif 1; other site 766760000323 active site 766760000324 motif 2; other site 766760000325 motif 3; other site 766760000326 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 766760000327 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 766760000328 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 766760000329 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 766760000330 ADP binding site [chemical binding]; other site 766760000331 phosphagen binding site; other site 766760000332 substrate specificity loop; other site 766760000333 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 766760000334 Clp amino terminal domain; Region: Clp_N; pfam02861 766760000335 Clp amino terminal domain; Region: Clp_N; pfam02861 766760000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760000337 Walker A motif; other site 766760000338 ATP binding site [chemical binding]; other site 766760000339 Walker B motif; other site 766760000340 arginine finger; other site 766760000341 UvrB/uvrC motif; Region: UVR; pfam02151 766760000342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760000343 Walker A motif; other site 766760000344 ATP binding site [chemical binding]; other site 766760000345 Walker B motif; other site 766760000346 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 766760000347 DNA repair protein RadA; Provisional; Region: PRK11823 766760000348 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 766760000349 Walker A motif/ATP binding site; other site 766760000350 ATP binding site [chemical binding]; other site 766760000351 Walker B motif; other site 766760000352 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 766760000353 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 766760000354 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 766760000355 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 766760000356 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 766760000357 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 766760000358 putative active site [active] 766760000359 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 766760000360 substrate binding site; other site 766760000361 dimer interface; other site 766760000362 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 766760000363 homotrimer interaction site [polypeptide binding]; other site 766760000364 zinc binding site [ion binding]; other site 766760000365 CDP-binding sites; other site 766760000366 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 766760000367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 766760000368 HIGH motif; other site 766760000369 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 766760000370 active site 766760000371 KMSKS motif; other site 766760000372 serine O-acetyltransferase; Region: cysE; TIGR01172 766760000373 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 766760000374 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 766760000375 trimer interface [polypeptide binding]; other site 766760000376 active site 766760000377 substrate binding site [chemical binding]; other site 766760000378 CoA binding site [chemical binding]; other site 766760000379 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 766760000380 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 766760000381 active site 766760000382 HIGH motif; other site 766760000383 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 766760000384 KMSKS motif; other site 766760000385 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 766760000386 tRNA binding surface [nucleotide binding]; other site 766760000387 anticodon binding site; other site 766760000388 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 766760000389 active site 766760000390 metal binding site [ion binding]; metal-binding site 766760000391 dimerization interface [polypeptide binding]; other site 766760000392 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 766760000393 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 766760000394 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 766760000395 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 766760000396 RNA polymerase factor sigma-70; Validated; Region: PRK08295 766760000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760000398 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 766760000399 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 766760000400 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 766760000401 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 766760000402 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 766760000403 putative homodimer interface [polypeptide binding]; other site 766760000404 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 766760000405 heterodimer interface [polypeptide binding]; other site 766760000406 homodimer interface [polypeptide binding]; other site 766760000407 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 766760000408 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 766760000409 23S rRNA interface [nucleotide binding]; other site 766760000410 L7/L12 interface [polypeptide binding]; other site 766760000411 putative thiostrepton binding site; other site 766760000412 L25 interface [polypeptide binding]; other site 766760000413 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 766760000414 mRNA/rRNA interface [nucleotide binding]; other site 766760000415 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 766760000416 23S rRNA interface [nucleotide binding]; other site 766760000417 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 766760000418 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 766760000419 core dimer interface [polypeptide binding]; other site 766760000420 peripheral dimer interface [polypeptide binding]; other site 766760000421 L10 interface [polypeptide binding]; other site 766760000422 L11 interface [polypeptide binding]; other site 766760000423 putative EF-Tu interaction site [polypeptide binding]; other site 766760000424 putative EF-G interaction site [polypeptide binding]; other site 766760000425 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 766760000426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760000427 S-adenosylmethionine binding site [chemical binding]; other site 766760000428 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 766760000429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 766760000430 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 766760000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 766760000432 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 766760000433 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 766760000434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 766760000435 RPB10 interaction site [polypeptide binding]; other site 766760000436 RPB1 interaction site [polypeptide binding]; other site 766760000437 RPB11 interaction site [polypeptide binding]; other site 766760000438 RPB3 interaction site [polypeptide binding]; other site 766760000439 RPB12 interaction site [polypeptide binding]; other site 766760000440 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 766760000441 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 766760000442 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 766760000443 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 766760000444 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 766760000445 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 766760000446 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 766760000447 G-loop; other site 766760000448 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 766760000449 DNA binding site [nucleotide binding] 766760000450 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 766760000451 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 766760000452 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 766760000453 S17 interaction site [polypeptide binding]; other site 766760000454 S8 interaction site; other site 766760000455 16S rRNA interaction site [nucleotide binding]; other site 766760000456 streptomycin interaction site [chemical binding]; other site 766760000457 23S rRNA interaction site [nucleotide binding]; other site 766760000458 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 766760000459 30S ribosomal protein S7; Validated; Region: PRK05302 766760000460 elongation factor G; Reviewed; Region: PRK00007 766760000461 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 766760000462 G1 box; other site 766760000463 putative GEF interaction site [polypeptide binding]; other site 766760000464 GTP/Mg2+ binding site [chemical binding]; other site 766760000465 Switch I region; other site 766760000466 G2 box; other site 766760000467 G3 box; other site 766760000468 Switch II region; other site 766760000469 G4 box; other site 766760000470 G5 box; other site 766760000471 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 766760000472 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 766760000473 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 766760000474 elongation factor Tu; Reviewed; Region: PRK00049 766760000475 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 766760000476 G1 box; other site 766760000477 GEF interaction site [polypeptide binding]; other site 766760000478 GTP/Mg2+ binding site [chemical binding]; other site 766760000479 Switch I region; other site 766760000480 G2 box; other site 766760000481 G3 box; other site 766760000482 Switch II region; other site 766760000483 G4 box; other site 766760000484 G5 box; other site 766760000485 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 766760000486 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 766760000487 Antibiotic Binding Site [chemical binding]; other site 766760000488 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 766760000489 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 766760000490 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 766760000491 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 766760000492 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 766760000493 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 766760000494 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 766760000495 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 766760000496 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 766760000497 putative translocon binding site; other site 766760000498 protein-rRNA interface [nucleotide binding]; other site 766760000499 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 766760000500 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 766760000501 G-X-X-G motif; other site 766760000502 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 766760000503 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 766760000504 23S rRNA interface [nucleotide binding]; other site 766760000505 5S rRNA interface [nucleotide binding]; other site 766760000506 putative antibiotic binding site [chemical binding]; other site 766760000507 L25 interface [polypeptide binding]; other site 766760000508 L27 interface [polypeptide binding]; other site 766760000509 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 766760000510 23S rRNA interface [nucleotide binding]; other site 766760000511 putative translocon interaction site; other site 766760000512 signal recognition particle (SRP54) interaction site; other site 766760000513 L23 interface [polypeptide binding]; other site 766760000514 trigger factor interaction site; other site 766760000515 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 766760000516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 766760000517 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 766760000518 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 766760000519 RNA binding site [nucleotide binding]; other site 766760000520 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 766760000521 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 766760000522 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 766760000523 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 766760000524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 766760000525 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 766760000526 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 766760000527 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 766760000528 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 766760000529 5S rRNA interface [nucleotide binding]; other site 766760000530 L27 interface [polypeptide binding]; other site 766760000531 23S rRNA interface [nucleotide binding]; other site 766760000532 L5 interface [polypeptide binding]; other site 766760000533 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 766760000534 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 766760000535 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 766760000536 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 766760000537 23S rRNA binding site [nucleotide binding]; other site 766760000538 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 766760000539 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 766760000540 SecY translocase; Region: SecY; pfam00344 766760000541 adenylate kinase; Reviewed; Region: adk; PRK00279 766760000542 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 766760000543 AMP-binding site [chemical binding]; other site 766760000544 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 766760000545 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 766760000546 active site 766760000547 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 766760000548 RNA binding site [nucleotide binding]; other site 766760000549 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 766760000550 rRNA binding site [nucleotide binding]; other site 766760000551 predicted 30S ribosome binding site; other site 766760000552 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 766760000553 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 766760000554 30S ribosomal protein S13; Region: bact_S13; TIGR03631 766760000555 30S ribosomal protein S11; Validated; Region: PRK05309 766760000556 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 766760000557 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 766760000558 alphaNTD homodimer interface [polypeptide binding]; other site 766760000559 alphaNTD - beta interaction site [polypeptide binding]; other site 766760000560 alphaNTD - beta' interaction site [polypeptide binding]; other site 766760000561 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 766760000562 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 766760000563 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 766760000564 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 766760000565 Walker A/P-loop; other site 766760000566 ATP binding site [chemical binding]; other site 766760000567 Q-loop/lid; other site 766760000568 ABC transporter signature motif; other site 766760000569 Walker B; other site 766760000570 D-loop; other site 766760000571 H-loop/switch region; other site 766760000572 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 766760000573 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 766760000574 Walker A/P-loop; other site 766760000575 ATP binding site [chemical binding]; other site 766760000576 Q-loop/lid; other site 766760000577 ABC transporter signature motif; other site 766760000578 Walker B; other site 766760000579 D-loop; other site 766760000580 H-loop/switch region; other site 766760000581 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 766760000582 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 766760000583 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 766760000584 dimerization interface 3.5A [polypeptide binding]; other site 766760000585 active site 766760000586 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 766760000587 23S rRNA interface [nucleotide binding]; other site 766760000588 L3 interface [polypeptide binding]; other site 766760000589 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 766760000590 DinB family; Region: DinB; cl17821 766760000591 DinB superfamily; Region: DinB_2; pfam12867 766760000592 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 766760000593 active site 766760000594 catalytic triad [active] 766760000595 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760000596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 766760000597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 766760000598 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760000599 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 766760000600 Walker A/P-loop; other site 766760000601 ATP binding site [chemical binding]; other site 766760000602 Q-loop/lid; other site 766760000603 ABC transporter signature motif; other site 766760000604 Walker B; other site 766760000605 D-loop; other site 766760000606 H-loop/switch region; other site 766760000607 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760000608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760000609 non-specific DNA binding site [nucleotide binding]; other site 766760000610 salt bridge; other site 766760000611 sequence-specific DNA binding site [nucleotide binding]; other site 766760000612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 766760000613 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760000614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 766760000615 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760000616 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760000617 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 766760000618 Walker A/P-loop; other site 766760000619 ATP binding site [chemical binding]; other site 766760000620 Q-loop/lid; other site 766760000621 ABC transporter signature motif; other site 766760000622 Walker B; other site 766760000623 D-loop; other site 766760000624 H-loop/switch region; other site 766760000625 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 766760000626 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 766760000627 putative active site [active] 766760000628 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760000629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760000630 Walker A/P-loop; other site 766760000631 ATP binding site [chemical binding]; other site 766760000632 Q-loop/lid; other site 766760000633 ABC transporter signature motif; other site 766760000634 Walker B; other site 766760000635 D-loop; other site 766760000636 H-loop/switch region; other site 766760000637 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 766760000638 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 766760000639 active site 766760000640 zinc binding site [ion binding]; other site 766760000641 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 766760000642 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 766760000643 active site 766760000644 zinc binding site [ion binding]; other site 766760000645 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 766760000646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760000647 ATP binding site [chemical binding]; other site 766760000648 Mg2+ binding site [ion binding]; other site 766760000649 G-X-G motif; other site 766760000650 Accessory gene regulator B; Region: AgrB; pfam04647 766760000651 Response regulator receiver domain; Region: Response_reg; pfam00072 766760000652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760000653 active site 766760000654 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 766760000655 phosphorylation site [posttranslational modification] 766760000656 intermolecular recognition site; other site 766760000657 dimerization interface [polypeptide binding]; other site 766760000658 LytTr DNA-binding domain; Region: LytTR; pfam04397 766760000659 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 766760000660 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 766760000661 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 766760000662 active site 766760000663 metal binding site [ion binding]; metal-binding site 766760000664 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 766760000665 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 766760000666 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 766760000667 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 766760000668 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 766760000669 Beta-lactamase; Region: Beta-lactamase; pfam00144 766760000670 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 766760000671 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 766760000672 Sodium Bile acid symporter family; Region: SBF; cl17470 766760000673 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 766760000674 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 766760000675 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 766760000676 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 766760000677 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 766760000678 putative periplasmic esterase; Provisional; Region: PRK03642 766760000679 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 766760000680 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760000681 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 766760000682 active site turn [active] 766760000683 phosphorylation site [posttranslational modification] 766760000684 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760000685 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 766760000686 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 766760000687 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 766760000688 putative active site [active] 766760000689 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 766760000690 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 766760000691 putative active site [active] 766760000692 Uncharacterized conserved protein [Function unknown]; Region: COG1683 766760000693 Arginase family; Region: Arginase; cd09989 766760000694 agmatinase; Region: agmatinase; TIGR01230 766760000695 active site 766760000696 Mn binding site [ion binding]; other site 766760000697 oligomer interface [polypeptide binding]; other site 766760000698 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 766760000699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760000700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760000701 DNA binding residues [nucleotide binding] 766760000702 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 766760000703 Putative zinc-finger; Region: zf-HC2; pfam13490 766760000704 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 766760000705 Uncharacterized conserved protein [Function unknown]; Region: COG1624 766760000706 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 766760000707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 766760000708 YbbR-like protein; Region: YbbR; pfam07949 766760000709 YbbR-like protein; Region: YbbR; pfam07949 766760000710 YbbR-like protein; Region: YbbR; pfam07949 766760000711 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 766760000712 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 766760000713 active site 766760000714 substrate binding site [chemical binding]; other site 766760000715 metal binding site [ion binding]; metal-binding site 766760000716 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 766760000717 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 766760000718 glutaminase active site [active] 766760000719 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 766760000720 dimer interface [polypeptide binding]; other site 766760000721 active site 766760000722 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 766760000723 dimer interface [polypeptide binding]; other site 766760000724 active site 766760000725 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 766760000726 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 766760000727 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760000728 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760000729 Walker A/P-loop; other site 766760000730 ATP binding site [chemical binding]; other site 766760000731 Q-loop/lid; other site 766760000732 ABC transporter signature motif; other site 766760000733 Walker B; other site 766760000734 D-loop; other site 766760000735 H-loop/switch region; other site 766760000736 Predicted transcriptional regulators [Transcription]; Region: COG1725 766760000737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760000738 DNA-binding site [nucleotide binding]; DNA binding site 766760000739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760000740 dimerization interface [polypeptide binding]; other site 766760000741 putative DNA binding site [nucleotide binding]; other site 766760000742 putative Zn2+ binding site [ion binding]; other site 766760000743 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 766760000744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760000745 putative substrate translocation pore; other site 766760000746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760000747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760000748 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760000749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 766760000750 metal-dependent hydrolase; Provisional; Region: PRK13291 766760000751 DinB superfamily; Region: DinB_2; pfam12867 766760000752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760000753 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760000754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760000755 Walker A/P-loop; other site 766760000756 ATP binding site [chemical binding]; other site 766760000757 Q-loop/lid; other site 766760000758 ABC transporter signature motif; other site 766760000759 Walker B; other site 766760000760 D-loop; other site 766760000761 H-loop/switch region; other site 766760000762 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 766760000763 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 766760000764 catalytic residues [active] 766760000765 Erythromycin esterase; Region: Erythro_esteras; cl17110 766760000766 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 766760000767 Phosphotransferase enzyme family; Region: APH; pfam01636 766760000768 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 766760000769 active site 766760000770 substrate binding site [chemical binding]; other site 766760000771 ATP binding site [chemical binding]; other site 766760000772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 766760000773 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 766760000774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760000775 active site 766760000776 motif I; other site 766760000777 motif II; other site 766760000778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 766760000779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760000780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760000781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 766760000782 dimerization interface [polypeptide binding]; other site 766760000783 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 766760000784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760000785 putative transporter; Provisional; Region: PRK10054 766760000786 putative substrate translocation pore; other site 766760000787 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 766760000788 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 766760000789 catalytic residues [active] 766760000790 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 766760000791 EamA-like transporter family; Region: EamA; pfam00892 766760000792 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 766760000793 EamA-like transporter family; Region: EamA; pfam00892 766760000794 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 766760000795 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 766760000796 DNA binding residues [nucleotide binding] 766760000797 putative dimer interface [polypeptide binding]; other site 766760000798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 766760000799 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 766760000800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760000801 S-adenosylmethionine binding site [chemical binding]; other site 766760000802 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 766760000803 dimer interface [polypeptide binding]; other site 766760000804 FMN binding site [chemical binding]; other site 766760000805 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760000806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760000807 DNA-binding site [nucleotide binding]; DNA binding site 766760000808 FCD domain; Region: FCD; pfam07729 766760000809 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 766760000810 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 766760000811 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 766760000812 NADP binding site [chemical binding]; other site 766760000813 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 766760000814 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 766760000815 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 766760000816 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 766760000817 PhoU domain; Region: PhoU; pfam01895 766760000818 PhoU domain; Region: PhoU; pfam01895 766760000819 yiaA/B two helix domain; Region: YiaAB; pfam05360 766760000820 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 766760000821 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 766760000822 EamA-like transporter family; Region: EamA; pfam00892 766760000823 EamA-like transporter family; Region: EamA; pfam00892 766760000824 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 766760000825 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760000826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760000827 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760000828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760000829 non-specific DNA binding site [nucleotide binding]; other site 766760000830 salt bridge; other site 766760000831 sequence-specific DNA binding site [nucleotide binding]; other site 766760000832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 766760000833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760000834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760000835 DNA binding residues [nucleotide binding] 766760000836 dimerization interface [polypeptide binding]; other site 766760000837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760000838 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 766760000839 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 766760000840 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 766760000841 putative active site [active] 766760000842 metal binding site [ion binding]; metal-binding site 766760000843 SurA N-terminal domain; Region: SurA_N_3; cl07813 766760000844 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 766760000845 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 766760000846 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 766760000847 S-methylmethionine transporter; Provisional; Region: PRK11387 766760000848 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 766760000849 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 766760000850 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 766760000851 putative active site [active] 766760000852 YdjC motif; other site 766760000853 Mg binding site [ion binding]; other site 766760000854 putative homodimer interface [polypeptide binding]; other site 766760000855 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 766760000856 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760000857 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760000858 active site turn [active] 766760000859 phosphorylation site [posttranslational modification] 766760000860 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 766760000861 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 766760000862 DNA binding residues [nucleotide binding] 766760000863 dimer interface [polypeptide binding]; other site 766760000864 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 766760000865 Predicted membrane protein [Function unknown]; Region: COG2323 766760000866 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 766760000867 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 766760000868 trimer interface [polypeptide binding]; other site 766760000869 active site 766760000870 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 766760000871 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 766760000872 amino acid carrier protein; Region: agcS; TIGR00835 766760000873 glutaminase; Reviewed; Region: PRK12357 766760000874 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 766760000875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760000876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760000877 ATP binding site [chemical binding]; other site 766760000878 Mg2+ binding site [ion binding]; other site 766760000879 G-X-G motif; other site 766760000880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760000881 Response regulator receiver domain; Region: Response_reg; pfam00072 766760000882 active site 766760000883 phosphorylation site [posttranslational modification] 766760000884 intermolecular recognition site; other site 766760000885 dimerization interface [polypeptide binding]; other site 766760000886 YcbB domain; Region: YcbB; pfam08664 766760000887 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760000888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760000889 Coenzyme A binding pocket [chemical binding]; other site 766760000890 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 766760000891 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 766760000892 Penicillinase repressor; Region: Pencillinase_R; pfam03965 766760000893 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 766760000894 PhoD-like phosphatase; Region: PhoD; pfam09423 766760000895 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 766760000896 putative active site [active] 766760000897 putative metal binding site [ion binding]; other site 766760000898 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 766760000899 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 766760000900 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 766760000901 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 766760000902 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 766760000903 putative active site [active] 766760000904 catalytic residue [active] 766760000905 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 766760000906 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 766760000907 NAD(P) binding site [chemical binding]; other site 766760000908 catalytic residues [active] 766760000909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760000910 D-galactonate transporter; Region: 2A0114; TIGR00893 766760000911 putative substrate translocation pore; other site 766760000912 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 766760000913 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 766760000914 active site 766760000915 tetramer interface [polypeptide binding]; other site 766760000916 Transcriptional regulators [Transcription]; Region: FadR; COG2186 766760000917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760000918 DNA-binding site [nucleotide binding]; DNA binding site 766760000919 FCD domain; Region: FCD; pfam07729 766760000920 galactarate dehydratase; Region: galactar-dH20; TIGR03248 766760000921 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 766760000922 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 766760000923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760000924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760000925 active site 766760000926 phosphorylation site [posttranslational modification] 766760000927 intermolecular recognition site; other site 766760000928 dimerization interface [polypeptide binding]; other site 766760000929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760000930 DNA binding site [nucleotide binding] 766760000931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760000932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760000933 dimer interface [polypeptide binding]; other site 766760000934 phosphorylation site [posttranslational modification] 766760000935 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 766760000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760000937 ATP binding site [chemical binding]; other site 766760000938 Mg2+ binding site [ion binding]; other site 766760000939 G-X-G motif; other site 766760000940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760000941 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 766760000942 Walker A/P-loop; other site 766760000943 ATP binding site [chemical binding]; other site 766760000944 Q-loop/lid; other site 766760000945 ABC transporter signature motif; other site 766760000946 Walker B; other site 766760000947 D-loop; other site 766760000948 H-loop/switch region; other site 766760000949 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 766760000950 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 766760000951 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 766760000952 Phosphotransferase enzyme family; Region: APH; pfam01636 766760000953 putative active site [active] 766760000954 putative substrate binding site [chemical binding]; other site 766760000955 ATP binding site [chemical binding]; other site 766760000956 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760000957 MarR family; Region: MarR; pfam01047 766760000958 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 766760000959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 766760000960 acyl-activating enzyme (AAE) consensus motif; other site 766760000961 AMP binding site [chemical binding]; other site 766760000962 active site 766760000963 CoA binding site [chemical binding]; other site 766760000964 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 766760000965 reactive center loop; other site 766760000966 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 766760000967 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 766760000968 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 766760000969 DNA binding residues [nucleotide binding] 766760000970 dimer interface [polypeptide binding]; other site 766760000971 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 766760000972 Predicted transcriptional regulators [Transcription]; Region: COG1695 766760000973 Transcriptional regulator PadR-like family; Region: PadR; cl17335 766760000974 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 766760000975 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 766760000976 dodecamer interface 1 [polypeptide binding]; other site 766760000977 dodecamer interface 2 [polypeptide binding]; other site 766760000978 trimer interface [polypeptide binding]; other site 766760000979 TRAP binding interface [polypeptide binding]; other site 766760000980 Zn binding site [ion binding]; other site 766760000981 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 766760000982 EamA-like transporter family; Region: EamA; cl17759 766760000983 EamA-like transporter family; Region: EamA; pfam00892 766760000984 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 766760000985 SEC-C motif; Region: SEC-C; pfam02810 766760000986 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 766760000987 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 766760000988 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 766760000989 Walker A/P-loop; other site 766760000990 ATP binding site [chemical binding]; other site 766760000991 Q-loop/lid; other site 766760000992 ABC transporter signature motif; other site 766760000993 Walker B; other site 766760000994 D-loop; other site 766760000995 H-loop/switch region; other site 766760000996 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 766760000997 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760000998 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 766760000999 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760001000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760001001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760001002 active site 766760001003 phosphorylation site [posttranslational modification] 766760001004 intermolecular recognition site; other site 766760001005 dimerization interface [polypeptide binding]; other site 766760001006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760001007 DNA binding site [nucleotide binding] 766760001008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760001009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760001010 dimer interface [polypeptide binding]; other site 766760001011 phosphorylation site [posttranslational modification] 766760001012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001013 ATP binding site [chemical binding]; other site 766760001014 Mg2+ binding site [ion binding]; other site 766760001015 G-X-G motif; other site 766760001016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760001017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760001018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760001019 dimerization interface [polypeptide binding]; other site 766760001020 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 766760001021 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 766760001022 classical (c) SDRs; Region: SDR_c; cd05233 766760001023 NAD(P) binding site [chemical binding]; other site 766760001024 active site 766760001025 hypothetical protein; Provisional; Region: PRK06922 766760001026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760001027 S-adenosylmethionine binding site [chemical binding]; other site 766760001028 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 766760001029 Predicted membrane protein [Function unknown]; Region: COG1288 766760001030 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 766760001031 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 766760001032 amidohydrolase; Region: amidohydrolases; TIGR01891 766760001033 metal binding site [ion binding]; metal-binding site 766760001034 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 766760001035 active site 766760001036 homotetramer interface [polypeptide binding]; other site 766760001037 homodimer interface [polypeptide binding]; other site 766760001038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760001039 Coenzyme A binding pocket [chemical binding]; other site 766760001040 amidase; Provisional; Region: PRK06529 766760001041 Amidase; Region: Amidase; cl11426 766760001042 oligoendopeptidase F; Region: pepF; TIGR00181 766760001043 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 766760001044 active site 766760001045 Zn binding site [ion binding]; other site 766760001046 Beta-lactamase; Region: Beta-lactamase; pfam00144 766760001047 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 766760001048 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 766760001049 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 766760001050 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 766760001051 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 766760001052 Cysteine-rich domain; Region: CCG; pfam02754 766760001053 Cysteine-rich domain; Region: CCG; pfam02754 766760001054 FAD binding domain; Region: FAD_binding_4; pfam01565 766760001055 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 766760001056 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 766760001057 active site 766760001058 P-loop; other site 766760001059 phosphorylation site [posttranslational modification] 766760001060 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 766760001061 methionine cluster; other site 766760001062 active site 766760001063 phosphorylation site [posttranslational modification] 766760001064 metal binding site [ion binding]; metal-binding site 766760001065 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 766760001066 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 766760001067 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 766760001068 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 766760001069 NAD binding site [chemical binding]; other site 766760001070 sugar binding site [chemical binding]; other site 766760001071 divalent metal binding site [ion binding]; other site 766760001072 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760001073 dimer interface [polypeptide binding]; other site 766760001074 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 766760001075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760001076 DNA-binding site [nucleotide binding]; DNA binding site 766760001077 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 766760001078 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 766760001079 putative active site [active] 766760001080 YdjC motif; other site 766760001081 Mg binding site [ion binding]; other site 766760001082 putative homodimer interface [polypeptide binding]; other site 766760001083 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 766760001084 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 766760001085 active site 766760001086 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 766760001087 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 766760001088 Interdomain contacts; other site 766760001089 Cytokine receptor motif; other site 766760001090 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 766760001091 aromatic chitin/cellulose binding site residues [chemical binding]; other site 766760001092 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 766760001093 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 766760001094 active site 766760001095 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 766760001096 Chitinase C; Region: ChiC; pfam06483 766760001097 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 766760001098 glucose-1-dehydrogenase; Provisional; Region: PRK08936 766760001099 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 766760001100 NAD binding site [chemical binding]; other site 766760001101 homodimer interface [polypeptide binding]; other site 766760001102 active site 766760001103 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 766760001104 Protein of unknown function; Region: DUF3658; pfam12395 766760001105 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 766760001106 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 766760001107 active site residue [active] 766760001108 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 766760001109 active site residue [active] 766760001110 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 766760001111 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 766760001112 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 766760001113 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 766760001114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 766760001115 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760001116 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760001117 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 766760001118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760001119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760001120 Walker A/P-loop; other site 766760001121 ATP binding site [chemical binding]; other site 766760001122 Q-loop/lid; other site 766760001123 ABC transporter signature motif; other site 766760001124 Walker B; other site 766760001125 D-loop; other site 766760001126 H-loop/switch region; other site 766760001127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760001128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760001129 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 766760001130 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 766760001131 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 766760001132 putative metal binding site [ion binding]; other site 766760001133 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 766760001134 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 766760001135 putative metal binding site [ion binding]; other site 766760001136 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 766760001137 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 766760001138 putative metal binding site [ion binding]; other site 766760001139 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 766760001140 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 766760001141 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 766760001142 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 766760001143 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 766760001144 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 766760001145 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 766760001146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001147 putative substrate translocation pore; other site 766760001148 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 766760001149 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 766760001150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760001151 NAD binding site [chemical binding]; other site 766760001152 dimer interface [polypeptide binding]; other site 766760001153 substrate binding site [chemical binding]; other site 766760001154 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 766760001155 L-lactate permease; Region: Lactate_perm; pfam02652 766760001156 LysE type translocator; Region: LysE; pfam01810 766760001157 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 766760001158 Spore germination protein; Region: Spore_permease; cl17796 766760001159 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 766760001160 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 766760001161 homodimer interface [polypeptide binding]; other site 766760001162 NAD binding pocket [chemical binding]; other site 766760001163 ATP binding pocket [chemical binding]; other site 766760001164 Mg binding site [ion binding]; other site 766760001165 active-site loop [active] 766760001166 shikimate kinase; Reviewed; Region: aroK; PRK00131 766760001167 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 766760001168 ADP binding site [chemical binding]; other site 766760001169 magnesium binding site [ion binding]; other site 766760001170 putative shikimate binding site; other site 766760001171 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 766760001172 Proline dehydrogenase; Region: Pro_dh; pfam01619 766760001173 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 766760001174 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 766760001175 Glutamate binding site [chemical binding]; other site 766760001176 homodimer interface [polypeptide binding]; other site 766760001177 NAD binding site [chemical binding]; other site 766760001178 catalytic residues [active] 766760001179 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 766760001180 Na binding site [ion binding]; other site 766760001181 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 766760001182 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 766760001183 Predicted membrane protein [Function unknown]; Region: COG3689 766760001184 Predicted permeases [General function prediction only]; Region: COG0701 766760001185 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 766760001186 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760001187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760001188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760001189 putative Zn2+ binding site [ion binding]; other site 766760001190 putative DNA binding site [nucleotide binding]; other site 766760001191 hypothetical protein; Provisional; Region: PRK09272 766760001192 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 766760001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760001194 dimer interface [polypeptide binding]; other site 766760001195 conserved gate region; other site 766760001196 putative PBP binding loops; other site 766760001197 ABC-ATPase subunit interface; other site 766760001198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 766760001199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 766760001200 substrate binding pocket [chemical binding]; other site 766760001201 membrane-bound complex binding site; other site 766760001202 hinge residues; other site 766760001203 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 766760001204 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760001205 Predicted ATPase [General function prediction only]; Region: COG3910 766760001206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760001207 Walker A/P-loop; other site 766760001208 ATP binding site [chemical binding]; other site 766760001209 Q-loop/lid; other site 766760001210 ABC transporter signature motif; other site 766760001211 Walker B; other site 766760001212 D-loop; other site 766760001213 H-loop/switch region; other site 766760001214 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 766760001215 beta-galactosidase; Region: BGL; TIGR03356 766760001216 Competence protein J (ComJ); Region: ComJ; pfam11033 766760001217 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 766760001218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 766760001219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 766760001220 active site 766760001221 ATP binding site [chemical binding]; other site 766760001222 substrate binding site [chemical binding]; other site 766760001223 activation loop (A-loop); other site 766760001224 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760001225 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 766760001226 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 766760001227 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 766760001228 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 766760001229 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 766760001230 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 766760001231 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 766760001232 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 766760001233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760001234 Walker A/P-loop; other site 766760001235 ATP binding site [chemical binding]; other site 766760001236 Q-loop/lid; other site 766760001237 ABC transporter signature motif; other site 766760001238 Walker B; other site 766760001239 D-loop; other site 766760001240 H-loop/switch region; other site 766760001241 TOBE domain; Region: TOBE_2; pfam08402 766760001242 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 766760001243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760001244 dimer interface [polypeptide binding]; other site 766760001245 conserved gate region; other site 766760001246 putative PBP binding loops; other site 766760001247 ABC-ATPase subunit interface; other site 766760001248 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 766760001249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760001250 dimer interface [polypeptide binding]; other site 766760001251 conserved gate region; other site 766760001252 putative PBP binding loops; other site 766760001253 ABC-ATPase subunit interface; other site 766760001254 Condensation domain; Region: Condensation; pfam00668 766760001255 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001256 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760001257 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760001258 acyl-activating enzyme (AAE) consensus motif; other site 766760001259 AMP binding site [chemical binding]; other site 766760001260 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001261 Condensation domain; Region: Condensation; pfam00668 766760001262 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001263 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760001264 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760001265 acyl-activating enzyme (AAE) consensus motif; other site 766760001266 AMP binding site [chemical binding]; other site 766760001267 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001268 Condensation domain; Region: Condensation; pfam00668 766760001269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001270 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760001271 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760001272 acyl-activating enzyme (AAE) consensus motif; other site 766760001273 AMP binding site [chemical binding]; other site 766760001274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001275 Condensation domain; Region: Condensation; pfam00668 766760001276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001277 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760001278 Condensation domain; Region: Condensation; pfam00668 766760001279 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001280 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760001281 acyl-activating enzyme (AAE) consensus motif; other site 766760001282 AMP binding site [chemical binding]; other site 766760001283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001284 Condensation domain; Region: Condensation; pfam00668 766760001285 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001286 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760001287 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760001288 acyl-activating enzyme (AAE) consensus motif; other site 766760001289 AMP binding site [chemical binding]; other site 766760001290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001291 Condensation domain; Region: Condensation; pfam00668 766760001292 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001293 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760001294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760001295 acyl-activating enzyme (AAE) consensus motif; other site 766760001296 AMP binding site [chemical binding]; other site 766760001297 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001298 Condensation domain; Region: Condensation; pfam00668 766760001299 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001300 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760001301 Condensation domain; Region: Condensation; pfam00668 766760001302 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760001303 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760001304 acyl-activating enzyme (AAE) consensus motif; other site 766760001305 AMP binding site [chemical binding]; other site 766760001306 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760001307 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 766760001308 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 766760001309 EamA-like transporter family; Region: EamA; pfam00892 766760001310 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 766760001311 EamA-like transporter family; Region: EamA; pfam00892 766760001312 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 766760001313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760001314 DNA-binding site [nucleotide binding]; DNA binding site 766760001315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760001316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760001317 homodimer interface [polypeptide binding]; other site 766760001318 catalytic residue [active] 766760001319 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 766760001320 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 766760001321 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 766760001322 Putative esterase; Region: Esterase; pfam00756 766760001323 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 766760001324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 766760001325 Predicted membrane protein [Function unknown]; Region: COG2364 766760001326 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760001327 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 766760001328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760001329 catalytic residue [active] 766760001330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760001331 dimerization interface [polypeptide binding]; other site 766760001332 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760001333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760001334 dimer interface [polypeptide binding]; other site 766760001335 putative CheW interface [polypeptide binding]; other site 766760001336 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 766760001337 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 766760001338 Walker A/P-loop; other site 766760001339 ATP binding site [chemical binding]; other site 766760001340 Q-loop/lid; other site 766760001341 ABC transporter signature motif; other site 766760001342 Walker B; other site 766760001343 D-loop; other site 766760001344 H-loop/switch region; other site 766760001345 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 766760001346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760001347 dimer interface [polypeptide binding]; other site 766760001348 conserved gate region; other site 766760001349 putative PBP binding loops; other site 766760001350 ABC-ATPase subunit interface; other site 766760001351 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 766760001352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 766760001353 substrate binding pocket [chemical binding]; other site 766760001354 membrane-bound complex binding site; other site 766760001355 hinge residues; other site 766760001356 PAS fold; Region: PAS; pfam00989 766760001357 PAS domain; Region: PAS; smart00091 766760001358 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 766760001359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760001360 Walker A motif; other site 766760001361 ATP binding site [chemical binding]; other site 766760001362 Walker B motif; other site 766760001363 arginine finger; other site 766760001364 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 766760001365 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 766760001366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760001367 inhibitor-cofactor binding pocket; inhibition site 766760001368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760001369 catalytic residue [active] 766760001370 S-methylmethionine transporter; Provisional; Region: PRK11387 766760001371 Arginase family; Region: Arginase; cd09989 766760001372 agmatinase; Region: agmatinase; TIGR01230 766760001373 active site 766760001374 Mn binding site [ion binding]; other site 766760001375 oligomer interface [polypeptide binding]; other site 766760001376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760001377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760001378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760001379 dimerization interface [polypeptide binding]; other site 766760001380 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 766760001381 Flavoprotein; Region: Flavoprotein; pfam02441 766760001382 UbiD family decarboxylase; Region: TIGR00148 766760001383 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 766760001384 hypothetical protein; Provisional; Region: PRK11371 766760001385 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 766760001386 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760001387 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 766760001388 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 766760001389 ligand binding site [chemical binding]; other site 766760001390 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 766760001391 Cache domain; Region: Cache_1; pfam02743 766760001392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760001393 dimerization interface [polypeptide binding]; other site 766760001394 Histidine kinase; Region: His_kinase; pfam06580 766760001395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001396 ATP binding site [chemical binding]; other site 766760001397 Mg2+ binding site [ion binding]; other site 766760001398 G-X-G motif; other site 766760001399 Response regulator receiver domain; Region: Response_reg; pfam00072 766760001400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760001401 active site 766760001402 phosphorylation site [posttranslational modification] 766760001403 intermolecular recognition site; other site 766760001404 dimerization interface [polypeptide binding]; other site 766760001405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760001406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760001407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760001408 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 766760001409 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 766760001410 putative ligand binding site [chemical binding]; other site 766760001411 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 766760001412 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 766760001413 Walker A/P-loop; other site 766760001414 ATP binding site [chemical binding]; other site 766760001415 Q-loop/lid; other site 766760001416 ABC transporter signature motif; other site 766760001417 Walker B; other site 766760001418 D-loop; other site 766760001419 H-loop/switch region; other site 766760001420 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 766760001421 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 766760001422 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 766760001423 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 766760001424 TM-ABC transporter signature motif; other site 766760001425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760001427 putative substrate translocation pore; other site 766760001428 Transcriptional regulators [Transcription]; Region: MarR; COG1846 766760001429 MarR family; Region: MarR; pfam01047 766760001430 MarR family; Region: MarR_2; cl17246 766760001431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760001432 Coenzyme A binding pocket [chemical binding]; other site 766760001433 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 766760001434 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 766760001435 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 766760001436 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 766760001437 Phytase; Region: Phytase; cl17685 766760001438 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 766760001439 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 766760001440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001441 putative substrate translocation pore; other site 766760001442 POT family; Region: PTR2; pfam00854 766760001443 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 766760001444 Right handed beta helix region; Region: Beta_helix; pfam13229 766760001445 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 766760001446 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 766760001447 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 766760001448 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 766760001449 Spore germination protein; Region: Spore_permease; pfam03845 766760001450 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 766760001451 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 766760001452 DNA binding residues [nucleotide binding] 766760001453 dimer interface [polypeptide binding]; other site 766760001454 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760001455 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760001456 Walker A/P-loop; other site 766760001457 ATP binding site [chemical binding]; other site 766760001458 Q-loop/lid; other site 766760001459 ABC transporter signature motif; other site 766760001460 Walker B; other site 766760001461 D-loop; other site 766760001462 H-loop/switch region; other site 766760001463 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 766760001464 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 766760001465 FtsX-like permease family; Region: FtsX; pfam02687 766760001466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760001467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760001468 active site 766760001469 phosphorylation site [posttranslational modification] 766760001470 intermolecular recognition site; other site 766760001471 dimerization interface [polypeptide binding]; other site 766760001472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760001473 DNA binding site [nucleotide binding] 766760001474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760001475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760001476 dimerization interface [polypeptide binding]; other site 766760001477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760001478 dimer interface [polypeptide binding]; other site 766760001479 phosphorylation site [posttranslational modification] 766760001480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001481 ATP binding site [chemical binding]; other site 766760001482 Mg2+ binding site [ion binding]; other site 766760001483 G-X-G motif; other site 766760001484 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 766760001485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760001486 dimerization interface [polypeptide binding]; other site 766760001487 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760001488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760001489 dimer interface [polypeptide binding]; other site 766760001490 putative CheW interface [polypeptide binding]; other site 766760001491 aspartate kinase; Reviewed; Region: PRK09034 766760001492 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 766760001493 putative catalytic residues [active] 766760001494 putative nucleotide binding site [chemical binding]; other site 766760001495 putative aspartate binding site [chemical binding]; other site 766760001496 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 766760001497 allosteric regulatory residue; other site 766760001498 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 766760001499 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 766760001500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760001501 ABC-ATPase subunit interface; other site 766760001502 dimer interface [polypeptide binding]; other site 766760001503 putative PBP binding regions; other site 766760001504 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760001505 ABC-ATPase subunit interface; other site 766760001506 dimer interface [polypeptide binding]; other site 766760001507 putative PBP binding regions; other site 766760001508 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 766760001509 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 766760001510 Walker A/P-loop; other site 766760001511 ATP binding site [chemical binding]; other site 766760001512 Q-loop/lid; other site 766760001513 ABC transporter signature motif; other site 766760001514 Walker B; other site 766760001515 D-loop; other site 766760001516 H-loop/switch region; other site 766760001517 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 766760001518 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 766760001519 putative ligand binding residues [chemical binding]; other site 766760001520 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 766760001521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001522 putative substrate translocation pore; other site 766760001523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760001524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760001525 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 766760001526 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 766760001527 tetramer interface [polypeptide binding]; other site 766760001528 active site 766760001529 Mg2+/Mn2+ binding site [ion binding]; other site 766760001530 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 766760001531 dimer interface [polypeptide binding]; other site 766760001532 FMN binding site [chemical binding]; other site 766760001533 NADPH bind site [chemical binding]; other site 766760001534 Uncharacterized conserved protein [Function unknown]; Region: COG1359 766760001535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760001536 dimerization interface [polypeptide binding]; other site 766760001537 putative DNA binding site [nucleotide binding]; other site 766760001538 putative Zn2+ binding site [ion binding]; other site 766760001539 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 766760001540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760001541 DNA-binding site [nucleotide binding]; DNA binding site 766760001542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760001543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760001544 homodimer interface [polypeptide binding]; other site 766760001545 catalytic residue [active] 766760001546 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 766760001547 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760001548 inhibitor-cofactor binding pocket; inhibition site 766760001549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760001550 catalytic residue [active] 766760001551 amino acid transporter; Region: 2A0306; TIGR00909 766760001552 succinic semialdehyde dehydrogenase; Region: PLN02278 766760001553 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 766760001554 tetramerization interface [polypeptide binding]; other site 766760001555 NAD(P) binding site [chemical binding]; other site 766760001556 catalytic residues [active] 766760001557 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 766760001558 EamA-like transporter family; Region: EamA; pfam00892 766760001559 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 766760001560 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 766760001561 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 766760001562 YtkA-like; Region: YtkA; pfam13115 766760001563 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 766760001564 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 766760001565 NosL; Region: NosL; cl01769 766760001566 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 766760001567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760001568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760001569 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 766760001570 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 766760001571 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 766760001572 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 766760001573 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 766760001574 [4Fe-4S] binding site [ion binding]; other site 766760001575 molybdopterin cofactor binding site; other site 766760001576 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 766760001577 molybdopterin cofactor binding site; other site 766760001578 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 766760001579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760001580 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 766760001581 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 766760001582 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 766760001583 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 766760001584 [2Fe-2S] cluster binding site [ion binding]; other site 766760001585 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 766760001586 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 766760001587 active site 766760001588 SAM binding site [chemical binding]; other site 766760001589 homodimer interface [polypeptide binding]; other site 766760001590 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760001591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760001592 DNA-binding site [nucleotide binding]; DNA binding site 766760001593 FCD domain; Region: FCD; pfam07729 766760001594 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 766760001595 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 766760001596 transmembrane helices; other site 766760001597 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 766760001598 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 766760001599 homodimer interaction site [polypeptide binding]; other site 766760001600 cofactor binding site; other site 766760001601 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 766760001602 HTH domain; Region: HTH_11; cl17392 766760001603 PRD domain; Region: PRD; pfam00874 766760001604 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 766760001605 active site 766760001606 P-loop; other site 766760001607 phosphorylation site [posttranslational modification] 766760001608 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760001609 active site 766760001610 phosphorylation site [posttranslational modification] 766760001611 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 766760001612 active site 766760001613 P-loop; other site 766760001614 phosphorylation site [posttranslational modification] 766760001615 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 766760001616 transketolase; Reviewed; Region: PRK05899 766760001617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 766760001618 TPP-binding site [chemical binding]; other site 766760001619 dimer interface [polypeptide binding]; other site 766760001620 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 766760001621 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 766760001622 PYR/PP interface [polypeptide binding]; other site 766760001623 dimer interface [polypeptide binding]; other site 766760001624 TPP binding site [chemical binding]; other site 766760001625 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 766760001626 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 766760001627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760001628 active site 766760001629 motif I; other site 766760001630 motif II; other site 766760001631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760001632 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 766760001633 putative active site [active] 766760001634 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 766760001635 hypothetical protein; Provisional; Region: PRK05463 766760001636 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 766760001637 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 766760001638 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 766760001639 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 766760001640 Transcriptional regulator [Transcription]; Region: IclR; COG1414 766760001641 Bacterial transcriptional regulator; Region: IclR; pfam01614 766760001642 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 766760001643 active site 766760001644 catalytic triad [active] 766760001645 oxyanion hole [active] 766760001646 Transposase domain (DUF772); Region: DUF772; pfam05598 766760001647 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760001648 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760001649 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 766760001650 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 766760001651 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 766760001652 active site 766760001653 P-loop; other site 766760001654 phosphorylation site [posttranslational modification] 766760001655 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760001656 active site 766760001657 phosphorylation site [posttranslational modification] 766760001658 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 766760001659 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 766760001660 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 766760001661 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 766760001662 HTH domain; Region: HTH_11; pfam08279 766760001663 HTH domain; Region: HTH_11; pfam08279 766760001664 PRD domain; Region: PRD; pfam00874 766760001665 PRD domain; Region: PRD; pfam00874 766760001666 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 766760001667 active site 766760001668 P-loop; other site 766760001669 phosphorylation site [posttranslational modification] 766760001670 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 766760001671 short chain dehydrogenase; Provisional; Region: PRK06701 766760001672 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 766760001673 NAD binding site [chemical binding]; other site 766760001674 metal binding site [ion binding]; metal-binding site 766760001675 active site 766760001676 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 766760001677 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 766760001678 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 766760001679 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 766760001680 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 766760001681 Transcriptional regulator [Transcription]; Region: LytR; COG1316 766760001682 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 766760001683 Uncharacterized conserved protein [Function unknown]; Region: COG2128 766760001684 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 766760001685 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 766760001686 putative DNA binding site [nucleotide binding]; other site 766760001687 putative Zn2+ binding site [ion binding]; other site 766760001688 AsnC family; Region: AsnC_trans_reg; pfam01037 766760001689 DNA topoisomerase III; Provisional; Region: PRK07726 766760001690 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 766760001691 active site 766760001692 putative interdomain interaction site [polypeptide binding]; other site 766760001693 putative metal-binding site [ion binding]; other site 766760001694 putative nucleotide binding site [chemical binding]; other site 766760001695 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 766760001696 domain I; other site 766760001697 DNA binding groove [nucleotide binding] 766760001698 phosphate binding site [ion binding]; other site 766760001699 domain II; other site 766760001700 domain III; other site 766760001701 nucleotide binding site [chemical binding]; other site 766760001702 catalytic site [active] 766760001703 domain IV; other site 766760001704 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 766760001705 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 766760001706 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 766760001707 Glutamine amidotransferase class-I; Region: GATase; pfam00117 766760001708 glutamine binding [chemical binding]; other site 766760001709 catalytic triad [active] 766760001710 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 766760001711 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 766760001712 chorismate binding enzyme; Region: Chorismate_bind; cl10555 766760001713 Chorismate mutase type II; Region: CM_2; cl00693 766760001714 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 766760001715 pyruvate oxidase; Provisional; Region: PRK08611 766760001716 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 766760001717 PYR/PP interface [polypeptide binding]; other site 766760001718 tetramer interface [polypeptide binding]; other site 766760001719 dimer interface [polypeptide binding]; other site 766760001720 TPP binding site [chemical binding]; other site 766760001721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 766760001722 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 766760001723 TPP-binding site [chemical binding]; other site 766760001724 Chitin binding domain; Region: Chitin_bind_3; pfam03067 766760001725 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760001726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760001727 manganese transport protein MntH; Reviewed; Region: PRK00701 766760001728 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 766760001729 aspartate ammonia-lyase; Provisional; Region: PRK14515 766760001730 Aspartase; Region: Aspartase; cd01357 766760001731 active sites [active] 766760001732 tetramer interface [polypeptide binding]; other site 766760001733 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 766760001734 glycosyltransferase, MGT family; Region: MGT; TIGR01426 766760001735 active site 766760001736 TDP-binding site; other site 766760001737 acceptor substrate-binding pocket; other site 766760001738 homodimer interface [polypeptide binding]; other site 766760001739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 766760001740 EcsC protein family; Region: EcsC; pfam12787 766760001741 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 766760001742 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 766760001743 General stress protein [General function prediction only]; Region: GsiB; COG3729 766760001744 General stress protein [General function prediction only]; Region: GsiB; COG3729 766760001745 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 766760001746 Domain of unknown function DUF20; Region: UPF0118; pfam01594 766760001747 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 766760001748 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 766760001749 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760001750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760001751 Walker A/P-loop; other site 766760001752 ATP binding site [chemical binding]; other site 766760001753 Q-loop/lid; other site 766760001754 ABC transporter signature motif; other site 766760001755 Walker B; other site 766760001756 D-loop; other site 766760001757 H-loop/switch region; other site 766760001758 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 766760001759 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760001760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 766760001761 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 766760001762 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 766760001763 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 766760001764 catalytic residues [active] 766760001765 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 766760001766 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 766760001767 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 766760001768 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 766760001769 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 766760001770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 766760001771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 766760001772 Esterase/lipase [General function prediction only]; Region: COG1647 766760001773 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 766760001774 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 766760001775 ATP binding site [chemical binding]; other site 766760001776 Mg++ binding site [ion binding]; other site 766760001777 motif III; other site 766760001778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760001779 nucleotide binding region [chemical binding]; other site 766760001780 ATP-binding site [chemical binding]; other site 766760001781 Uncharacterized conserved protein [Function unknown]; Region: COG3402 766760001782 Predicted membrane protein [Function unknown]; Region: COG3428 766760001783 Bacterial PH domain; Region: DUF304; pfam03703 766760001784 Bacterial PH domain; Region: DUF304; pfam03703 766760001785 Bacterial PH domain; Region: DUF304; pfam03703 766760001786 Rhomboid family; Region: Rhomboid; pfam01694 766760001787 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 766760001788 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 766760001789 alanine racemase; Region: alr; TIGR00492 766760001790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 766760001791 active site 766760001792 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 766760001793 dimer interface [polypeptide binding]; other site 766760001794 substrate binding site [chemical binding]; other site 766760001795 catalytic residues [active] 766760001796 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 766760001797 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 766760001798 Rsbr N terminal; Region: Rsbr_N; pfam08678 766760001799 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 766760001800 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 766760001801 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 766760001802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001803 ATP binding site [chemical binding]; other site 766760001804 Mg2+ binding site [ion binding]; other site 766760001805 G-X-G motif; other site 766760001806 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 766760001807 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 766760001808 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 766760001809 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 766760001810 anti sigma factor interaction site; other site 766760001811 regulatory phosphorylation site [posttranslational modification]; other site 766760001812 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 766760001813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001814 ATP binding site [chemical binding]; other site 766760001815 Mg2+ binding site [ion binding]; other site 766760001816 G-X-G motif; other site 766760001817 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 766760001818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760001819 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 766760001820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760001821 DNA binding residues [nucleotide binding] 766760001822 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 766760001823 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 766760001824 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 766760001825 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 766760001826 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 766760001827 RNA binding site [nucleotide binding]; other site 766760001828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760001829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760001830 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 766760001831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760001832 MMPL family; Region: MMPL; pfam03176 766760001833 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 766760001834 Not1 N-terminal domain, CCR4-Not complex component; Region: Not3; pfam04065 766760001835 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 766760001836 LMBR1-like membrane protein; Region: LMBR1; pfam04791 766760001837 hypothetical protein; Provisional; Region: PRK04351 766760001838 SprT homologues; Region: SprT; cl01182 766760001839 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 766760001840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760001841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760001842 non-specific DNA binding site [nucleotide binding]; other site 766760001843 salt bridge; other site 766760001844 sequence-specific DNA binding site [nucleotide binding]; other site 766760001845 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 766760001846 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 766760001847 putative di-iron ligands [ion binding]; other site 766760001848 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 766760001849 DNA-binding site [nucleotide binding]; DNA binding site 766760001850 RNA-binding motif; other site 766760001851 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 766760001852 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 766760001853 NADP binding site [chemical binding]; other site 766760001854 dimer interface [polypeptide binding]; other site 766760001855 Predicted membrane protein [Function unknown]; Region: COG2364 766760001856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760001857 MarR family; Region: MarR; pfam01047 766760001858 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 766760001859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760001860 Coenzyme A binding pocket [chemical binding]; other site 766760001861 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 766760001862 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 766760001863 active site 766760001864 Mn binding site [ion binding]; other site 766760001865 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760001866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760001867 dimerization interface [polypeptide binding]; other site 766760001868 putative DNA binding site [nucleotide binding]; other site 766760001869 putative Zn2+ binding site [ion binding]; other site 766760001870 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760001871 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760001872 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760001873 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760001874 Cytotoxic; Region: Cytotoxic; pfam09000 766760001875 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760001876 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760001877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760001878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760001879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760001880 dimerization interface [polypeptide binding]; other site 766760001881 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 766760001882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760001883 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760001884 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001886 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760001887 putative substrate translocation pore; other site 766760001888 Putative cyclase; Region: Cyclase; pfam04199 766760001889 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 766760001890 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 766760001891 DGC domain; Region: DGC; pfam08859 766760001892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 766760001893 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 766760001894 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 766760001895 catalytic site [active] 766760001896 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 766760001897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760001898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760001899 DNA binding residues [nucleotide binding] 766760001900 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 766760001901 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 766760001902 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 766760001903 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 766760001904 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 766760001905 catalytic triad [active] 766760001906 catalytic triad [active] 766760001907 oxyanion hole [active] 766760001908 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 766760001909 nudix motif; other site 766760001910 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 766760001911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001912 putative substrate translocation pore; other site 766760001913 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 766760001914 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 766760001915 dimer interface [polypeptide binding]; other site 766760001916 active site 766760001917 metal binding site [ion binding]; metal-binding site 766760001918 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 766760001919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760001920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760001921 dimer interface [polypeptide binding]; other site 766760001922 phosphorylation site [posttranslational modification] 766760001923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001924 ATP binding site [chemical binding]; other site 766760001925 Mg2+ binding site [ion binding]; other site 766760001926 G-X-G motif; other site 766760001927 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 766760001928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760001929 active site 766760001930 phosphorylation site [posttranslational modification] 766760001931 intermolecular recognition site; other site 766760001932 dimerization interface [polypeptide binding]; other site 766760001933 Histidine kinase; Region: His_kinase; pfam06580 766760001934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760001935 ATP binding site [chemical binding]; other site 766760001936 Mg2+ binding site [ion binding]; other site 766760001937 G-X-G motif; other site 766760001938 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 766760001939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760001940 active site 766760001941 phosphorylation site [posttranslational modification] 766760001942 intermolecular recognition site; other site 766760001943 dimerization interface [polypeptide binding]; other site 766760001944 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 766760001945 DNA binding site [nucleotide binding] 766760001946 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 766760001947 Collagen binding domain; Region: Collagen_bind; pfam05737 766760001948 Collagen binding domain; Region: Collagen_bind; pfam05737 766760001949 Collagen binding domain; Region: Collagen_bind; pfam05737 766760001950 Collagen binding domain; Region: Collagen_bind; pfam05737 766760001951 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001952 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001953 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001954 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 766760001955 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001956 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001957 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001958 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001959 Cna protein B-type domain; Region: Cna_B; pfam05738 766760001960 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 766760001961 active site 766760001962 catalytic site [active] 766760001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001964 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 766760001965 putative substrate translocation pore; other site 766760001966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760001967 thiamine monophosphate kinase; Provisional; Region: PRK05731 766760001968 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 766760001969 ATP binding site [chemical binding]; other site 766760001970 dimerization interface [polypeptide binding]; other site 766760001971 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 766760001972 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 766760001973 Glycoprotease family; Region: Peptidase_M22; pfam00814 766760001974 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 766760001975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760001976 Coenzyme A binding pocket [chemical binding]; other site 766760001977 UGMP family protein; Validated; Region: PRK09604 766760001978 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 766760001979 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 766760001980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760001981 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760001982 ABC transporter; Region: ABC_tran_2; pfam12848 766760001983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760001984 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 766760001985 trimer interface [polypeptide binding]; other site 766760001986 dimer interface [polypeptide binding]; other site 766760001987 putative active site [active] 766760001988 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 766760001989 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 766760001990 CoA binding domain; Region: CoA_binding; pfam02629 766760001991 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 766760001992 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 766760001993 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 766760001994 CAAX protease self-immunity; Region: Abi; pfam02517 766760001995 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 766760001996 oligomerisation interface [polypeptide binding]; other site 766760001997 mobile loop; other site 766760001998 roof hairpin; other site 766760001999 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 766760002000 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 766760002001 ring oligomerisation interface [polypeptide binding]; other site 766760002002 ATP/Mg binding site [chemical binding]; other site 766760002003 stacking interactions; other site 766760002004 hinge regions; other site 766760002005 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 766760002006 Int/Topo IB signature motif; other site 766760002007 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 766760002008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760002009 non-specific DNA binding site [nucleotide binding]; other site 766760002010 salt bridge; other site 766760002011 sequence-specific DNA binding site [nucleotide binding]; other site 766760002012 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 766760002013 Catalytic site [active] 766760002014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760002015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760002016 non-specific DNA binding site [nucleotide binding]; other site 766760002017 salt bridge; other site 766760002018 sequence-specific DNA binding site [nucleotide binding]; other site 766760002019 Phage anti-repressor protein [Transcription]; Region: COG3561 766760002020 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 766760002021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 766760002022 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 766760002023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760002024 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760002025 Walker A/P-loop; other site 766760002026 ATP binding site [chemical binding]; other site 766760002027 Protein of unknown function (DUF669); Region: DUF669; pfam05037 766760002028 Uncharacterized conserved protein [Function unknown]; Region: COG4983 766760002029 D5 N terminal like; Region: D5_N; pfam08706 766760002030 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 766760002031 ERCC4 domain; Region: ERCC4; smart00891 766760002032 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 766760002033 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 766760002034 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 766760002035 Phage terminase, small subunit; Region: Terminase_4; pfam05119 766760002036 Phage Terminase; Region: Terminase_1; pfam03354 766760002037 Phage-related protein [Function unknown]; Region: COG4695; cl01923 766760002038 Phage portal protein; Region: Phage_portal; pfam04860 766760002039 Phage head maturation protease [General function prediction only]; Region: COG3740 766760002040 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 766760002041 Phage capsid family; Region: Phage_capsid; pfam05065 766760002042 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 766760002043 oligomerization interface [polypeptide binding]; other site 766760002044 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 766760002045 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 766760002046 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 766760002047 Phage-related minor tail protein [Function unknown]; Region: COG5280 766760002048 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 766760002049 N-acetyl-D-glucosamine binding site [chemical binding]; other site 766760002050 catalytic residue [active] 766760002051 Phage tail protein; Region: Sipho_tail; pfam05709 766760002052 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 766760002053 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 766760002054 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 766760002055 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 766760002056 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 766760002057 Haemolysin XhlA; Region: XhlA; pfam10779 766760002058 holin, SPP1 family; Region: holin_SPP1; TIGR01592 766760002059 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 766760002060 amidase catalytic site [active] 766760002061 Zn binding residues [ion binding]; other site 766760002062 substrate binding site [chemical binding]; other site 766760002063 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 766760002064 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760002065 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 766760002066 VanW like protein; Region: VanW; pfam04294 766760002067 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 766760002068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760002069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760002070 Coenzyme A binding pocket [chemical binding]; other site 766760002071 Uncharacterized conserved protein [Function unknown]; Region: COG2135 766760002072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760002073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760002074 phosphoenolpyruvate synthase; Validated; Region: PRK06241 766760002075 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 766760002076 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 766760002077 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 766760002078 Uncharacterized conserved protein [Function unknown]; Region: COG3189 766760002079 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 766760002080 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 766760002081 putative NAD(P) binding site [chemical binding]; other site 766760002082 active site 766760002083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 766760002084 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 766760002085 substrate binding pocket [chemical binding]; other site 766760002086 catalytic triad [active] 766760002087 D-galactonate transporter; Region: 2A0114; TIGR00893 766760002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760002089 putative substrate translocation pore; other site 766760002090 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 766760002091 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 766760002092 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 766760002093 Repair protein; Region: Repair_PSII; pfam04536 766760002094 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 766760002095 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 766760002096 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 766760002097 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 766760002098 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 766760002099 Predicted transcriptional regulators [Transcription]; Region: COG1378 766760002100 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 766760002101 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 766760002102 C-terminal domain interface [polypeptide binding]; other site 766760002103 sugar binding site [chemical binding]; other site 766760002104 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 766760002105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760002106 sequence-specific DNA binding site [nucleotide binding]; other site 766760002107 salt bridge; other site 766760002108 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 766760002109 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 766760002110 cell division protein FtsW; Region: ftsW; TIGR02614 766760002111 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 766760002112 dimer interface [polypeptide binding]; other site 766760002113 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760002114 Predicted transcriptional regulator [Transcription]; Region: COG2378 766760002115 HTH domain; Region: HTH_11; pfam08279 766760002116 WYL domain; Region: WYL; pfam13280 766760002117 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 766760002118 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 766760002119 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 766760002120 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 766760002121 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 766760002122 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 766760002123 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 766760002124 active site 766760002125 Na/Ca binding site [ion binding]; other site 766760002126 catalytic site [active] 766760002127 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 766760002128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760002129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760002130 DNA binding site [nucleotide binding] 766760002131 domain linker motif; other site 766760002132 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 766760002133 ligand binding site [chemical binding]; other site 766760002134 dimerization interface [polypeptide binding]; other site 766760002135 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 766760002136 homodimer interface [polypeptide binding]; other site 766760002137 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 766760002138 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 766760002139 active site 766760002140 homodimer interface [polypeptide binding]; other site 766760002141 catalytic site [active] 766760002142 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 766760002143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760002144 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 766760002145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760002146 dimer interface [polypeptide binding]; other site 766760002147 conserved gate region; other site 766760002148 putative PBP binding loops; other site 766760002149 ABC-ATPase subunit interface; other site 766760002150 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760002152 dimer interface [polypeptide binding]; other site 766760002153 conserved gate region; other site 766760002154 putative PBP binding loops; other site 766760002155 ABC-ATPase subunit interface; other site 766760002156 Predicted integral membrane protein [Function unknown]; Region: COG5521 766760002157 maltose phosphorylase; Provisional; Region: PRK13807 766760002158 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 766760002159 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 766760002160 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 766760002161 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 766760002162 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 766760002163 Ca binding site [ion binding]; other site 766760002164 active site 766760002165 catalytic site [active] 766760002166 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 766760002167 beta-phosphoglucomutase; Region: bPGM; TIGR01990 766760002168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760002169 motif II; other site 766760002170 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 766760002171 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 766760002172 active site 766760002173 HIGH motif; other site 766760002174 dimer interface [polypeptide binding]; other site 766760002175 KMSKS motif; other site 766760002176 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760002177 RNA binding surface [nucleotide binding]; other site 766760002178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760002179 MarR family; Region: MarR; pfam01047 766760002180 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 766760002181 anti-sigma E factor; Provisional; Region: rseB; PRK09455 766760002182 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 766760002183 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 766760002184 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 766760002185 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 766760002186 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 766760002187 Catalytic site [active] 766760002188 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 766760002189 NADH(P)-binding; Region: NAD_binding_10; pfam13460 766760002190 NAD(P) binding site [chemical binding]; other site 766760002191 putative active site [active] 766760002192 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 766760002193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760002194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 766760002196 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 766760002197 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 766760002198 Multicopper oxidase; Region: Cu-oxidase; pfam00394 766760002199 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 766760002200 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 766760002201 Acyltransferase family; Region: Acyl_transf_3; pfam01757 766760002202 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 766760002203 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 766760002204 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 766760002205 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 766760002206 MoxR-like ATPases [General function prediction only]; Region: COG0714 766760002207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760002208 Walker A motif; other site 766760002209 ATP binding site [chemical binding]; other site 766760002210 Walker B motif; other site 766760002211 arginine finger; other site 766760002212 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 766760002213 Protein of unknown function DUF58; Region: DUF58; pfam01882 766760002214 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 766760002215 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 766760002216 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 766760002217 GMP synthase; Reviewed; Region: guaA; PRK00074 766760002218 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 766760002219 AMP/PPi binding site [chemical binding]; other site 766760002220 candidate oxyanion hole; other site 766760002221 catalytic triad [active] 766760002222 potential glutamine specificity residues [chemical binding]; other site 766760002223 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 766760002224 ATP Binding subdomain [chemical binding]; other site 766760002225 Ligand Binding sites [chemical binding]; other site 766760002226 Dimerization subdomain; other site 766760002227 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 766760002228 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 766760002229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 766760002230 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760002231 NETI protein; Region: NETI; pfam14044 766760002232 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 766760002233 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 766760002234 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 766760002235 ATP-grasp domain; Region: ATP-grasp; pfam02222 766760002236 adenylosuccinate lyase; Provisional; Region: PRK07492 766760002237 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 766760002238 tetramer interface [polypeptide binding]; other site 766760002239 active site 766760002240 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 766760002241 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 766760002242 ATP binding site [chemical binding]; other site 766760002243 active site 766760002244 substrate binding site [chemical binding]; other site 766760002245 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 766760002246 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 766760002247 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 766760002248 putative active site [active] 766760002249 catalytic triad [active] 766760002250 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 766760002251 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 766760002252 dimerization interface [polypeptide binding]; other site 766760002253 ATP binding site [chemical binding]; other site 766760002254 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 766760002255 dimerization interface [polypeptide binding]; other site 766760002256 ATP binding site [chemical binding]; other site 766760002257 amidophosphoribosyltransferase; Provisional; Region: PRK07631 766760002258 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 766760002259 active site 766760002260 tetramer interface [polypeptide binding]; other site 766760002261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760002262 active site 766760002263 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 766760002264 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 766760002265 dimerization interface [polypeptide binding]; other site 766760002266 putative ATP binding site [chemical binding]; other site 766760002267 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 766760002268 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 766760002269 active site 766760002270 substrate binding site [chemical binding]; other site 766760002271 cosubstrate binding site; other site 766760002272 catalytic site [active] 766760002273 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 766760002274 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 766760002275 purine monophosphate binding site [chemical binding]; other site 766760002276 dimer interface [polypeptide binding]; other site 766760002277 putative catalytic residues [active] 766760002278 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 766760002279 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 766760002280 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 766760002281 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 766760002282 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 766760002283 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 766760002284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760002285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760002286 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 766760002287 Cytochrome P450; Region: p450; cl12078 766760002288 ANTAR domain; Region: ANTAR; cl04297 766760002289 Transposase domain (DUF772); Region: DUF772; pfam05598 766760002290 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 766760002291 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 766760002292 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 766760002293 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 766760002294 active site 766760002295 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 766760002296 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 766760002297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 766760002298 PcrB family; Region: PcrB; pfam01884 766760002299 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 766760002300 substrate binding site [chemical binding]; other site 766760002301 putative active site [active] 766760002302 dimer interface [polypeptide binding]; other site 766760002303 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 766760002304 Part of AAA domain; Region: AAA_19; pfam13245 766760002305 Family description; Region: UvrD_C_2; pfam13538 766760002306 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 766760002307 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 766760002308 nucleotide binding pocket [chemical binding]; other site 766760002309 K-X-D-G motif; other site 766760002310 catalytic site [active] 766760002311 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 766760002312 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 766760002313 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 766760002314 Dimer interface [polypeptide binding]; other site 766760002315 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 766760002316 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 766760002317 putative dimer interface [polypeptide binding]; other site 766760002318 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 766760002319 putative dimer interface [polypeptide binding]; other site 766760002320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 766760002321 DNA-binding site [nucleotide binding]; DNA binding site 766760002322 PRD domain; Region: PRD; pfam00874 766760002323 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 766760002324 Protein of unknown function; Region: YhfT; pfam10797 766760002325 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 766760002326 active site 766760002327 substrate binding pocket [chemical binding]; other site 766760002328 homodimer interaction site [polypeptide binding]; other site 766760002329 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 766760002330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760002331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 766760002332 catalytic residue [active] 766760002333 putative mutase; Provisional; Region: PRK12383 766760002334 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 766760002335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 766760002336 dimer interface [polypeptide binding]; other site 766760002337 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 766760002338 active site 766760002339 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 766760002340 substrate binding site [chemical binding]; other site 766760002341 catalytic residue [active] 766760002342 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 766760002343 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 766760002344 active site 766760002345 trimer interface [polypeptide binding]; other site 766760002346 allosteric site; other site 766760002347 active site lid [active] 766760002348 hexamer (dimer of trimers) interface [polypeptide binding]; other site 766760002349 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 766760002350 MgtC family; Region: MgtC; pfam02308 766760002351 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 766760002352 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 766760002353 Na binding site [ion binding]; other site 766760002354 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 766760002355 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 766760002356 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 766760002357 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 766760002358 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 766760002359 GatB domain; Region: GatB_Yqey; pfam02637 766760002360 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 766760002361 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 766760002362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760002363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760002364 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 766760002365 Protein export membrane protein; Region: SecD_SecF; cl14618 766760002366 Protein export membrane protein; Region: SecD_SecF; cl14618 766760002367 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760002368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760002369 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 766760002370 active site 766760002371 dimerization interface [polypeptide binding]; other site 766760002372 putative lipid kinase; Reviewed; Region: PRK13337 766760002373 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 766760002374 TRAM domain; Region: TRAM; pfam01938 766760002375 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 766760002376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760002377 S-adenosylmethionine binding site [chemical binding]; other site 766760002378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760002379 ATP-binding site [chemical binding]; other site 766760002380 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 766760002381 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 766760002382 PLD-like domain; Region: PLDc_2; pfam13091 766760002383 putative active site [active] 766760002384 catalytic site [active] 766760002385 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 766760002386 cofactor binding site; other site 766760002387 DNA binding site [nucleotide binding] 766760002388 substrate interaction site [chemical binding]; other site 766760002389 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 766760002390 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 766760002391 transcriptional antiterminator BglG; Provisional; Region: PRK09772 766760002392 CAT RNA binding domain; Region: CAT_RBD; smart01061 766760002393 PRD domain; Region: PRD; pfam00874 766760002394 PRD domain; Region: PRD; pfam00874 766760002395 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760002396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760002397 S-adenosylmethionine binding site [chemical binding]; other site 766760002398 Part of AAA domain; Region: AAA_19; pfam13245 766760002399 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 766760002400 AAA domain; Region: AAA_12; pfam13087 766760002401 Uncharacterized conserved protein [Function unknown]; Region: COG3586 766760002402 EamA-like transporter family; Region: EamA; pfam00892 766760002403 EamA-like transporter family; Region: EamA; pfam00892 766760002404 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 766760002405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760002406 DNA-binding site [nucleotide binding]; DNA binding site 766760002407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760002408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760002409 homodimer interface [polypeptide binding]; other site 766760002410 catalytic residue [active] 766760002411 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 766760002412 EamA-like transporter family; Region: EamA; pfam00892 766760002413 EamA-like transporter family; Region: EamA; pfam00892 766760002414 hypothetical protein; Provisional; Region: PRK12378 766760002415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760002416 non-specific DNA binding site [nucleotide binding]; other site 766760002417 salt bridge; other site 766760002418 sequence-specific DNA binding site [nucleotide binding]; other site 766760002419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760002420 dimerization interface [polypeptide binding]; other site 766760002421 putative DNA binding site [nucleotide binding]; other site 766760002422 putative Zn2+ binding site [ion binding]; other site 766760002423 LUC7 N_terminus; Region: LUC7; pfam03194 766760002424 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 766760002425 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 766760002426 NAD(P) binding site [chemical binding]; other site 766760002427 catalytic residues [active] 766760002428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760002429 dimer interface [polypeptide binding]; other site 766760002430 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760002431 putative CheW interface [polypeptide binding]; other site 766760002432 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 766760002433 UbiA prenyltransferase family; Region: UbiA; pfam01040 766760002434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760002435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760002436 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 766760002437 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 766760002438 transmembrane helices; other site 766760002439 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 766760002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760002441 Walker A/P-loop; other site 766760002442 ATP binding site [chemical binding]; other site 766760002443 Q-loop/lid; other site 766760002444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760002445 ABC transporter signature motif; other site 766760002446 Walker B; other site 766760002447 D-loop; other site 766760002448 ABC transporter; Region: ABC_tran_2; pfam12848 766760002449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760002450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760002451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760002452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760002453 dimerization interface [polypeptide binding]; other site 766760002454 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 766760002455 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 766760002456 conserved cys residue [active] 766760002457 putative GTP cyclohydrolase; Provisional; Region: PRK13674 766760002458 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 766760002459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 766760002460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760002461 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 766760002462 G1 box; other site 766760002463 GTP/Mg2+ binding site [chemical binding]; other site 766760002464 G2 box; other site 766760002465 Switch I region; other site 766760002466 G3 box; other site 766760002467 Switch II region; other site 766760002468 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 766760002469 Nucleoside recognition; Region: Gate; pfam07670 766760002470 Nucleoside recognition; Region: Gate; pfam07670 766760002471 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 766760002472 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 766760002473 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 766760002474 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 766760002475 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 766760002476 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760002477 inhibitor-cofactor binding pocket; inhibition site 766760002478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760002479 catalytic residue [active] 766760002480 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 766760002481 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 766760002482 substrate-cofactor binding pocket; other site 766760002483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760002484 catalytic residue [active] 766760002485 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 766760002486 AAA domain; Region: AAA_26; pfam13500 766760002487 biotin synthase; Validated; Region: PRK06256 766760002488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760002489 FeS/SAM binding site; other site 766760002490 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 766760002491 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 766760002492 Cytochrome P450; Region: p450; cl12078 766760002493 Ion transport protein; Region: Ion_trans; pfam00520 766760002494 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 766760002495 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 766760002496 DNA binding residues [nucleotide binding] 766760002497 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 766760002498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760002499 putative substrate translocation pore; other site 766760002500 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 766760002501 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760002502 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760002503 ABC transporter; Region: ABC_tran_2; pfam12848 766760002504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760002505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 766760002506 DEAD-like helicases superfamily; Region: DEXDc; smart00487 766760002507 ATP binding site [chemical binding]; other site 766760002508 putative Mg++ binding site [ion binding]; other site 766760002509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760002510 nucleotide binding region [chemical binding]; other site 766760002511 ATP-binding site [chemical binding]; other site 766760002512 Prostaglandin dehydrogenases; Region: PGDH; cd05288 766760002513 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 766760002514 NAD(P) binding site [chemical binding]; other site 766760002515 substrate binding site [chemical binding]; other site 766760002516 dimer interface [polypeptide binding]; other site 766760002517 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 766760002518 Heat induced stress protein YflT; Region: YflT; pfam11181 766760002519 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 766760002520 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 766760002521 transmembrane helices; other site 766760002522 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760002523 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760002524 Walker A/P-loop; other site 766760002525 ATP binding site [chemical binding]; other site 766760002526 Q-loop/lid; other site 766760002527 ABC transporter signature motif; other site 766760002528 Walker B; other site 766760002529 D-loop; other site 766760002530 H-loop/switch region; other site 766760002531 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 766760002532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 766760002533 FtsX-like permease family; Region: FtsX; pfam02687 766760002534 FtsX-like permease family; Region: FtsX; pfam02687 766760002535 VanZ like family; Region: VanZ; pfam04892 766760002536 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760002537 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760002538 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_5; cd06242 766760002539 putative active site [active] 766760002540 Zn binding site [ion binding]; other site 766760002541 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 766760002542 active site 766760002543 dimer interface [polypeptide binding]; other site 766760002544 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 766760002545 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 766760002546 active site 766760002547 Predicted integral membrane protein [Function unknown]; Region: COG5658 766760002548 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 766760002549 SdpI/YhfL protein family; Region: SdpI; pfam13630 766760002550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760002551 dimerization interface [polypeptide binding]; other site 766760002552 putative DNA binding site [nucleotide binding]; other site 766760002553 putative Zn2+ binding site [ion binding]; other site 766760002554 acylphosphatase; Provisional; Region: PRK14420 766760002555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 766760002556 MOSC domain; Region: MOSC; pfam03473 766760002557 3-alpha domain; Region: 3-alpha; pfam03475 766760002558 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 766760002559 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 766760002560 active site 766760002561 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 766760002562 Sulfatase; Region: Sulfatase; pfam00884 766760002563 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 766760002564 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 766760002565 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 766760002566 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 766760002567 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760002568 active site turn [active] 766760002569 phosphorylation site [posttranslational modification] 766760002570 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760002571 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 766760002572 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 766760002573 Ca binding site [ion binding]; other site 766760002574 active site 766760002575 catalytic site [active] 766760002576 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 766760002577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760002578 DNA-binding site [nucleotide binding]; DNA binding site 766760002579 UTRA domain; Region: UTRA; pfam07702 766760002580 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 766760002581 putative trimer interface [polypeptide binding]; other site 766760002582 putative CoA binding site [chemical binding]; other site 766760002583 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 766760002584 putative trimer interface [polypeptide binding]; other site 766760002585 putative active site [active] 766760002586 putative substrate binding site [chemical binding]; other site 766760002587 putative CoA binding site [chemical binding]; other site 766760002588 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 766760002589 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 766760002590 inhibitor-cofactor binding pocket; inhibition site 766760002591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760002592 catalytic residue [active] 766760002593 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 766760002594 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 766760002595 putative trimer interface [polypeptide binding]; other site 766760002596 putative CoA binding site [chemical binding]; other site 766760002597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 766760002598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760002599 NAD(P) binding site [chemical binding]; other site 766760002600 active site 766760002601 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 766760002602 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760002603 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 766760002604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760002605 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 766760002606 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 766760002607 active site 766760002608 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 766760002609 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 766760002610 putative metal binding site; other site 766760002611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760002612 binding surface 766760002613 TPR motif; other site 766760002614 TPR repeat; Region: TPR_11; pfam13414 766760002615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 766760002616 binding surface 766760002617 TPR motif; other site 766760002618 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 766760002619 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 766760002620 inhibitor-cofactor binding pocket; inhibition site 766760002621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760002622 catalytic residue [active] 766760002623 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760002624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760002625 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 766760002626 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 766760002627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760002628 NAD(P) binding site [chemical binding]; other site 766760002629 active site 766760002630 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 766760002631 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 766760002632 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 766760002633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760002634 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760002635 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760002636 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 766760002637 FMN binding site [chemical binding]; other site 766760002638 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 766760002639 dimer interface [polypeptide binding]; other site 766760002640 FMN binding site [chemical binding]; other site 766760002641 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 766760002642 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 766760002643 active site 766760002644 metal binding site [ion binding]; metal-binding site 766760002645 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 766760002646 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 766760002647 active site 766760002648 metal binding site [ion binding]; metal-binding site 766760002649 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 766760002650 intracellular protease, PfpI family; Region: PfpI; TIGR01382 766760002651 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 766760002652 proposed catalytic triad [active] 766760002653 conserved cys residue [active] 766760002654 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 766760002655 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 766760002656 amino acid carrier protein; Region: agcS; TIGR00835 766760002657 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 766760002658 Low molecular weight phosphatase family; Region: LMWPc; cd00115 766760002659 active site 766760002660 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 766760002661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760002662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760002663 putative substrate translocation pore; other site 766760002664 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 766760002665 calcium/proton exchanger (cax); Region: cax; TIGR00378 766760002666 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 766760002667 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 766760002668 YfkD-like protein; Region: YfkD; pfam14167 766760002669 Radical SAM superfamily; Region: Radical_SAM; pfam04055 766760002670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760002671 FeS/SAM binding site; other site 766760002672 YfkB-like domain; Region: YfkB; pfam08756 766760002673 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 766760002674 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 766760002675 NodB motif; other site 766760002676 active site 766760002677 catalytic site [active] 766760002678 Cd binding site [ion binding]; other site 766760002679 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 766760002680 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 766760002681 dimer interface [polypeptide binding]; other site 766760002682 active site 766760002683 metal binding site [ion binding]; metal-binding site 766760002684 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 766760002685 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 766760002686 oligomer interface [polypeptide binding]; other site 766760002687 metal binding site [ion binding]; metal-binding site 766760002688 metal binding site [ion binding]; metal-binding site 766760002689 putative Cl binding site [ion binding]; other site 766760002690 aspartate ring; other site 766760002691 basic sphincter; other site 766760002692 hydrophobic gate; other site 766760002693 periplasmic entrance; other site 766760002694 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 766760002695 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 766760002696 minor groove reading motif; other site 766760002697 helix-hairpin-helix signature motif; other site 766760002698 substrate binding pocket [chemical binding]; other site 766760002699 active site 766760002700 TRAM domain; Region: TRAM; pfam01938 766760002701 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 766760002702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760002703 S-adenosylmethionine binding site [chemical binding]; other site 766760002704 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 766760002705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760002706 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760002707 DNA binding residues [nucleotide binding] 766760002708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760002709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760002710 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 766760002711 glycosyltransferase, MGT family; Region: MGT; TIGR01426 766760002712 active site 766760002713 TDP-binding site; other site 766760002714 acceptor substrate-binding pocket; other site 766760002715 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 766760002716 benzoate transport; Region: 2A0115; TIGR00895 766760002717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760002718 putative substrate translocation pore; other site 766760002719 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 766760002720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760002721 active site turn [active] 766760002722 phosphorylation site [posttranslational modification] 766760002723 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760002724 transcriptional antiterminator BglG; Provisional; Region: PRK09772 766760002725 CAT RNA binding domain; Region: CAT_RBD; smart01061 766760002726 PRD domain; Region: PRD; pfam00874 766760002727 PRD domain; Region: PRD; pfam00874 766760002728 Carbonic anhydrase; Region: Pro_CA; pfam00484 766760002729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 766760002730 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 766760002731 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 766760002732 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 766760002733 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 766760002734 DJ-1 family protein; Region: not_thiJ; TIGR01383 766760002735 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 766760002736 conserved cys residue [active] 766760002737 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 766760002738 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 766760002739 tetramer interface [polypeptide binding]; other site 766760002740 TPP-binding site [chemical binding]; other site 766760002741 heterodimer interface [polypeptide binding]; other site 766760002742 phosphorylation loop region [posttranslational modification] 766760002743 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 766760002744 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 766760002745 alpha subunit interface [polypeptide binding]; other site 766760002746 TPP binding site [chemical binding]; other site 766760002747 heterodimer interface [polypeptide binding]; other site 766760002748 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 766760002749 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 766760002750 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 766760002751 E3 interaction surface; other site 766760002752 lipoyl attachment site [posttranslational modification]; other site 766760002753 e3 binding domain; Region: E3_binding; pfam02817 766760002754 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 766760002755 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 766760002756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760002757 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 766760002758 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 766760002759 GAF domain; Region: GAF; cl17456 766760002760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760002761 Walker A motif; other site 766760002762 ATP binding site [chemical binding]; other site 766760002763 Walker B motif; other site 766760002764 arginine finger; other site 766760002765 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 766760002766 hypothetical protein; Provisional; Region: PRK02237 766760002767 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 766760002768 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 766760002769 NAD binding site [chemical binding]; other site 766760002770 sugar binding site [chemical binding]; other site 766760002771 divalent metal binding site [ion binding]; other site 766760002772 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760002773 dimer interface [polypeptide binding]; other site 766760002774 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 766760002775 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 766760002776 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 766760002777 putative active site [active] 766760002778 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 766760002779 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 766760002780 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760002781 active site turn [active] 766760002782 phosphorylation site [posttranslational modification] 766760002783 Methyltransferase domain; Region: Methyltransf_23; pfam13489 766760002784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760002785 S-adenosylmethionine binding site [chemical binding]; other site 766760002786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 766760002787 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 766760002788 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760002789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760002790 dimerization interface [polypeptide binding]; other site 766760002791 putative Zn2+ binding site [ion binding]; other site 766760002792 putative DNA binding site [nucleotide binding]; other site 766760002793 Predicted membrane protein [Function unknown]; Region: COG2259 766760002794 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 766760002795 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 766760002796 putative metal binding site [ion binding]; other site 766760002797 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 766760002798 active site 766760002799 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 766760002800 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 766760002801 active site 766760002802 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 766760002803 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 766760002804 inhibitor binding site; inhibition site 766760002805 active site 766760002806 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 766760002807 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 766760002808 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760002809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760002810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760002811 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 766760002812 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760002813 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 766760002814 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 766760002815 nudix motif; other site 766760002816 metal-dependent hydrolase; Provisional; Region: PRK13291 766760002817 DinB superfamily; Region: DinB_2; pfam12867 766760002818 Predicted integral membrane protein [Function unknown]; Region: COG0392 766760002819 Uncharacterized conserved protein [Function unknown]; Region: COG2898 766760002820 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 766760002821 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 766760002822 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 766760002823 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 766760002824 putative FMN binding site [chemical binding]; other site 766760002825 YfhD-like protein; Region: YfhD; pfam14151 766760002826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760002827 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 766760002828 TIGR01777 family protein; Region: yfcH 766760002829 putative NAD(P) binding site [chemical binding]; other site 766760002830 putative active site [active] 766760002831 recombination regulator RecX; Provisional; Region: recX; PRK14135 766760002832 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 766760002833 YpzG-like protein; Region: YpzG; pfam14139 766760002834 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 766760002835 WVELL protein; Region: WVELL; pfam14043 766760002836 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 766760002837 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 766760002838 Ligand binding site; other site 766760002839 Putative Catalytic site; other site 766760002840 DXD motif; other site 766760002841 Predicted membrane protein [Function unknown]; Region: COG2246 766760002842 GtrA-like protein; Region: GtrA; pfam04138 766760002843 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 766760002844 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 766760002845 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 766760002846 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 766760002847 minor groove reading motif; other site 766760002848 helix-hairpin-helix signature motif; other site 766760002849 substrate binding pocket [chemical binding]; other site 766760002850 active site 766760002851 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 766760002852 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 766760002853 DNA binding and oxoG recognition site [nucleotide binding] 766760002854 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 766760002855 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 766760002856 putative NAD(P) binding site [chemical binding]; other site 766760002857 active site 766760002858 YgaB-like protein; Region: YgaB; pfam14182 766760002859 hypothetical protein; Provisional; Region: PRK13662 766760002860 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760002861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760002862 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 766760002863 Walker A/P-loop; other site 766760002864 ATP binding site [chemical binding]; other site 766760002865 Q-loop/lid; other site 766760002866 ABC transporter signature motif; other site 766760002867 Walker B; other site 766760002868 D-loop; other site 766760002869 H-loop/switch region; other site 766760002870 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 766760002871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760002872 Walker A/P-loop; other site 766760002873 ATP binding site [chemical binding]; other site 766760002874 Q-loop/lid; other site 766760002875 ABC transporter signature motif; other site 766760002876 Walker B; other site 766760002877 D-loop; other site 766760002878 H-loop/switch region; other site 766760002879 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 766760002880 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 766760002881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760002882 Walker A/P-loop; other site 766760002883 ATP binding site [chemical binding]; other site 766760002884 Q-loop/lid; other site 766760002885 ABC transporter signature motif; other site 766760002886 Walker B; other site 766760002887 D-loop; other site 766760002888 H-loop/switch region; other site 766760002889 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 766760002890 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 766760002891 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 766760002892 peptide binding site [polypeptide binding]; other site 766760002893 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 766760002894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760002895 dimer interface [polypeptide binding]; other site 766760002896 conserved gate region; other site 766760002897 putative PBP binding loops; other site 766760002898 ABC-ATPase subunit interface; other site 766760002899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 766760002900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760002901 dimer interface [polypeptide binding]; other site 766760002902 conserved gate region; other site 766760002903 putative PBP binding loops; other site 766760002904 ABC-ATPase subunit interface; other site 766760002905 Transposase domain (DUF772); Region: DUF772; pfam05598 766760002906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760002907 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760002908 Predicted membrane protein [Function unknown]; Region: COG4129 766760002909 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 766760002910 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 766760002911 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760002912 inhibitor-cofactor binding pocket; inhibition site 766760002913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760002914 catalytic residue [active] 766760002915 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 766760002916 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 766760002917 catalytic triad [active] 766760002918 ferric uptake regulator; Provisional; Region: fur; PRK09462 766760002919 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 766760002920 metal binding site 2 [ion binding]; metal-binding site 766760002921 putative DNA binding helix; other site 766760002922 metal binding site 1 [ion binding]; metal-binding site 766760002923 dimer interface [polypeptide binding]; other site 766760002924 structural Zn2+ binding site [ion binding]; other site 766760002925 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 766760002926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760002927 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760002928 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 766760002929 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 766760002930 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 766760002931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760002932 ATP binding site [chemical binding]; other site 766760002933 putative Mg++ binding site [ion binding]; other site 766760002934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 766760002935 nucleotide binding region [chemical binding]; other site 766760002936 ATP-binding site [chemical binding]; other site 766760002937 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 766760002938 HsdM N-terminal domain; Region: HsdM_N; pfam12161 766760002939 Methyltransferase domain; Region: Methyltransf_26; pfam13659 766760002940 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 766760002941 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 766760002942 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 766760002943 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 766760002944 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 766760002945 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 766760002946 active site 766760002947 Zn binding site [ion binding]; other site 766760002948 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 766760002949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760002950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760002951 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 766760002952 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 766760002953 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 766760002954 active site 766760002955 catalytic residue [active] 766760002956 dimer interface [polypeptide binding]; other site 766760002957 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 766760002958 ThiC-associated domain; Region: ThiC-associated; pfam13667 766760002959 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 766760002960 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 766760002961 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 766760002962 Walker A/P-loop; other site 766760002963 ATP binding site [chemical binding]; other site 766760002964 Q-loop/lid; other site 766760002965 ABC transporter signature motif; other site 766760002966 Walker B; other site 766760002967 D-loop; other site 766760002968 H-loop/switch region; other site 766760002969 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 766760002970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 766760002971 substrate binding pocket [chemical binding]; other site 766760002972 membrane-bound complex binding site; other site 766760002973 hinge residues; other site 766760002974 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 766760002975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760002976 dimer interface [polypeptide binding]; other site 766760002977 conserved gate region; other site 766760002978 putative PBP binding loops; other site 766760002979 ABC-ATPase subunit interface; other site 766760002980 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 766760002981 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 766760002982 active site 766760002983 dimer interface [polypeptide binding]; other site 766760002984 non-prolyl cis peptide bond; other site 766760002985 insertion regions; other site 766760002986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760002987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760002988 non-specific DNA binding site [nucleotide binding]; other site 766760002989 salt bridge; other site 766760002990 sequence-specific DNA binding site [nucleotide binding]; other site 766760002991 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 766760002992 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760002993 Walker A/P-loop; other site 766760002994 ATP binding site [chemical binding]; other site 766760002995 Q-loop/lid; other site 766760002996 ABC transporter signature motif; other site 766760002997 Walker B; other site 766760002998 D-loop; other site 766760002999 H-loop/switch region; other site 766760003000 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 766760003001 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 766760003002 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 766760003003 B3/4 domain; Region: B3_4; pfam03483 766760003004 epoxyqueuosine reductase; Region: TIGR00276 766760003005 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 766760003006 4Fe-4S binding domain; Region: Fer4; pfam00037 766760003007 HEAT repeats; Region: HEAT_2; pfam13646 766760003008 Putative amidase domain; Region: Amidase_6; pfam12671 766760003009 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 766760003010 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 766760003011 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 766760003012 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 766760003013 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 766760003014 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 766760003015 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 766760003016 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 766760003017 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 766760003018 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 766760003019 carboxyltransferase (CT) interaction site; other site 766760003020 biotinylation site [posttranslational modification]; other site 766760003021 HlyD family secretion protein; Region: HlyD_3; pfam13437 766760003022 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 766760003023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760003024 putative substrate translocation pore; other site 766760003025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760003026 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 766760003027 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760003028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760003029 Q-loop/lid; other site 766760003030 ABC transporter signature motif; other site 766760003031 Walker B; other site 766760003032 D-loop; other site 766760003033 H-loop/switch region; other site 766760003034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760003035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760003036 Walker A/P-loop; other site 766760003037 ATP binding site [chemical binding]; other site 766760003038 Q-loop/lid; other site 766760003039 ABC transporter signature motif; other site 766760003040 Walker B; other site 766760003041 D-loop; other site 766760003042 H-loop/switch region; other site 766760003043 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 766760003044 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760003045 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 766760003046 DNA-binding site [nucleotide binding]; DNA binding site 766760003047 RNA-binding motif; other site 766760003048 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 766760003049 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 766760003050 Walker A/P-loop; other site 766760003051 ATP binding site [chemical binding]; other site 766760003052 Q-loop/lid; other site 766760003053 ABC transporter signature motif; other site 766760003054 Walker B; other site 766760003055 D-loop; other site 766760003056 H-loop/switch region; other site 766760003057 NIL domain; Region: NIL; pfam09383 766760003058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003059 dimer interface [polypeptide binding]; other site 766760003060 conserved gate region; other site 766760003061 ABC-ATPase subunit interface; other site 766760003062 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 766760003063 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 766760003064 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 766760003065 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 766760003066 FOG: WD40 repeat [General function prediction only]; Region: COG2319 766760003067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760003068 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760003069 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 766760003070 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 766760003071 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 766760003072 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 766760003073 PAS domain; Region: PAS_10; pfam13596 766760003074 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 766760003075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760003076 putative active site [active] 766760003077 heme pocket [chemical binding]; other site 766760003078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760003079 dimer interface [polypeptide binding]; other site 766760003080 phosphorylation site [posttranslational modification] 766760003081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760003082 ATP binding site [chemical binding]; other site 766760003083 Mg2+ binding site [ion binding]; other site 766760003084 G-X-G motif; other site 766760003085 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 766760003086 generic binding surface II; other site 766760003087 generic binding surface I; other site 766760003088 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 766760003089 generic binding surface II; other site 766760003090 generic binding surface I; other site 766760003091 Staphylococcal nuclease homologues; Region: SNc; smart00318 766760003092 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 766760003093 Catalytic site; other site 766760003094 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 766760003095 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 766760003096 putative active site [active] 766760003097 putative metal binding site [ion binding]; other site 766760003098 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 766760003099 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 766760003100 active site 766760003101 catalytic site [active] 766760003102 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 766760003103 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 766760003104 active site 766760003105 FOG: CBS domain [General function prediction only]; Region: COG0517 766760003106 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 766760003107 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 766760003108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760003109 motif II; other site 766760003110 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 766760003111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760003112 Coenzyme A binding pocket [chemical binding]; other site 766760003113 Predicted amidohydrolase [General function prediction only]; Region: COG0388 766760003114 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 766760003115 putative active site [active] 766760003116 catalytic triad [active] 766760003117 putative dimer interface [polypeptide binding]; other site 766760003118 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 766760003119 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760003120 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760003121 ABC transporter; Region: ABC_tran_2; pfam12848 766760003122 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760003123 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 766760003124 Predicted permeases [General function prediction only]; Region: COG0679 766760003125 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 766760003126 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 766760003127 NAD(P) binding site [chemical binding]; other site 766760003128 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 766760003129 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 766760003130 amphipathic channel; other site 766760003131 Asn-Pro-Ala signature motifs; other site 766760003132 glycerol kinase; Provisional; Region: glpK; PRK00047 766760003133 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 766760003134 N- and C-terminal domain interface [polypeptide binding]; other site 766760003135 active site 766760003136 MgATP binding site [chemical binding]; other site 766760003137 catalytic site [active] 766760003138 metal binding site [ion binding]; metal-binding site 766760003139 glycerol binding site [chemical binding]; other site 766760003140 homotetramer interface [polypeptide binding]; other site 766760003141 homodimer interface [polypeptide binding]; other site 766760003142 FBP binding site [chemical binding]; other site 766760003143 protein IIAGlc interface [polypeptide binding]; other site 766760003144 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 766760003145 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 766760003146 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 766760003147 active site 766760003148 substrate binding site [chemical binding]; other site 766760003149 metal binding site [ion binding]; metal-binding site 766760003150 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760003151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760003152 non-specific DNA binding site [nucleotide binding]; other site 766760003153 salt bridge; other site 766760003154 sequence-specific DNA binding site [nucleotide binding]; other site 766760003155 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 766760003156 GAF domain; Region: GAF; pfam01590 766760003157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760003158 Histidine kinase; Region: HisKA_3; pfam07730 766760003159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760003160 ATP binding site [chemical binding]; other site 766760003161 Mg2+ binding site [ion binding]; other site 766760003162 G-X-G motif; other site 766760003163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760003164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760003165 active site 766760003166 phosphorylation site [posttranslational modification] 766760003167 intermolecular recognition site; other site 766760003168 dimerization interface [polypeptide binding]; other site 766760003169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760003170 DNA binding residues [nucleotide binding] 766760003171 dimerization interface [polypeptide binding]; other site 766760003172 Predicted flavoprotein [General function prediction only]; Region: COG0431 766760003173 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760003174 YhdB-like protein; Region: YhdB; pfam14148 766760003175 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 766760003176 Transcriptional regulator; Region: Rrf2; cl17282 766760003177 Rrf2 family protein; Region: rrf2_super; TIGR00738 766760003178 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 766760003179 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 766760003180 heme-binding site [chemical binding]; other site 766760003181 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 766760003182 FAD binding pocket [chemical binding]; other site 766760003183 FAD binding motif [chemical binding]; other site 766760003184 phosphate binding motif [ion binding]; other site 766760003185 beta-alpha-beta structure motif; other site 766760003186 NAD binding pocket [chemical binding]; other site 766760003187 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 766760003188 SpoVR like protein; Region: SpoVR; pfam04293 766760003189 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760003190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760003191 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760003192 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760003193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760003194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760003195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760003196 dimerization interface [polypeptide binding]; other site 766760003197 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 766760003198 dimer interface [polypeptide binding]; other site 766760003199 Citrate synthase; Region: Citrate_synt; pfam00285 766760003200 active site 766760003201 citrylCoA binding site [chemical binding]; other site 766760003202 oxalacetate/citrate binding site [chemical binding]; other site 766760003203 coenzyme A binding site [chemical binding]; other site 766760003204 catalytic triad [active] 766760003205 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 766760003206 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 766760003207 short chain dehydrogenase; Provisional; Region: PRK06701 766760003208 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 766760003209 NAD binding site [chemical binding]; other site 766760003210 metal binding site [ion binding]; metal-binding site 766760003211 active site 766760003212 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 766760003213 Na2 binding site [ion binding]; other site 766760003214 putative substrate binding site 1 [chemical binding]; other site 766760003215 Na binding site 1 [ion binding]; other site 766760003216 putative substrate binding site 2 [chemical binding]; other site 766760003217 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 766760003218 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760003219 catalytic residue [active] 766760003220 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760003221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760003222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 766760003223 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 766760003224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760003225 DNA-binding site [nucleotide binding]; DNA binding site 766760003226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760003227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003228 homodimer interface [polypeptide binding]; other site 766760003229 catalytic residue [active] 766760003230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760003231 Coenzyme A binding pocket [chemical binding]; other site 766760003232 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 766760003233 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 766760003234 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 766760003235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760003236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760003237 DNA binding residues [nucleotide binding] 766760003238 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 766760003239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 766760003240 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 766760003241 active site 766760003242 catalytic tetrad [active] 766760003243 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 766760003244 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 766760003245 putative acyl-acceptor binding pocket; other site 766760003246 Protein of unknown function (DUF805); Region: DUF805; pfam05656 766760003247 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 766760003248 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 766760003249 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 766760003250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760003251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760003252 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 766760003253 Domain of unknown function DUF21; Region: DUF21; pfam01595 766760003254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 766760003255 Transporter associated domain; Region: CorC_HlyC; smart01091 766760003256 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 766760003257 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 766760003258 DNA binding residues [nucleotide binding] 766760003259 putative dimer interface [polypeptide binding]; other site 766760003260 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 766760003261 Domain of unknown function DUF21; Region: DUF21; pfam01595 766760003262 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 766760003263 Transporter associated domain; Region: CorC_HlyC; smart01091 766760003264 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 766760003265 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 766760003266 active site 766760003267 metal binding site [ion binding]; metal-binding site 766760003268 camphor resistance protein CrcB; Provisional; Region: PRK14213 766760003269 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 766760003270 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 766760003271 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 766760003272 active site 766760003273 catalytic site [active] 766760003274 metal binding site [ion binding]; metal-binding site 766760003275 dimer interface [polypeptide binding]; other site 766760003276 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 766760003277 Mechanosensitive ion channel; Region: MS_channel; pfam00924 766760003278 NAD-dependent deacetylase; Provisional; Region: PRK00481 766760003279 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 766760003280 NAD+ binding site [chemical binding]; other site 766760003281 substrate binding site [chemical binding]; other site 766760003282 Zn binding site [ion binding]; other site 766760003283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 766760003284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760003285 Coenzyme A binding pocket [chemical binding]; other site 766760003286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760003287 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 766760003288 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 766760003289 NodB motif; other site 766760003290 active site 766760003291 catalytic site [active] 766760003292 Zn binding site [ion binding]; other site 766760003293 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 766760003294 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 766760003295 homodimer interface [polypeptide binding]; other site 766760003296 substrate-cofactor binding pocket; other site 766760003297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003298 catalytic residue [active] 766760003299 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 766760003300 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 766760003301 active site 766760003302 catalytic residues [active] 766760003303 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 766760003304 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 766760003305 YcaO-like family; Region: YcaO; pfam02624 766760003306 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 766760003307 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 766760003308 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 766760003309 Ligand Binding Site [chemical binding]; other site 766760003310 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 766760003311 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760003312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760003313 Walker A/P-loop; other site 766760003314 ATP binding site [chemical binding]; other site 766760003315 Q-loop/lid; other site 766760003316 ABC transporter signature motif; other site 766760003317 Walker B; other site 766760003318 D-loop; other site 766760003319 H-loop/switch region; other site 766760003320 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760003321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760003322 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 766760003323 Walker A/P-loop; other site 766760003324 ATP binding site [chemical binding]; other site 766760003325 Q-loop/lid; other site 766760003326 ABC transporter signature motif; other site 766760003327 Walker B; other site 766760003328 D-loop; other site 766760003329 H-loop/switch region; other site 766760003330 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 766760003331 NADH(P)-binding; Region: NAD_binding_10; pfam13460 766760003332 NAD binding site [chemical binding]; other site 766760003333 substrate binding site [chemical binding]; other site 766760003334 putative active site [active] 766760003335 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 766760003336 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 766760003337 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 766760003338 Walker A/P-loop; other site 766760003339 ATP binding site [chemical binding]; other site 766760003340 Q-loop/lid; other site 766760003341 ABC transporter signature motif; other site 766760003342 Walker B; other site 766760003343 D-loop; other site 766760003344 H-loop/switch region; other site 766760003345 TOBE domain; Region: TOBE; pfam03459 766760003346 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 766760003347 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 766760003348 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 766760003349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 766760003350 hypothetical protein; Provisional; Region: PRK13676 766760003351 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 766760003352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760003353 active site 766760003354 motif I; other site 766760003355 motif II; other site 766760003356 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 766760003357 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 766760003358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760003359 FeS/SAM binding site; other site 766760003360 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 766760003361 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 766760003362 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 766760003363 TrkA-C domain; Region: TrkA_C; pfam02080 766760003364 enoyl-CoA hydratase; Provisional; Region: PRK07659 766760003365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760003366 substrate binding site [chemical binding]; other site 766760003367 oxyanion hole (OAH) forming residues; other site 766760003368 trimer interface [polypeptide binding]; other site 766760003369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760003370 TPR motif; other site 766760003371 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760003372 binding surface 766760003373 YhzD-like protein; Region: YhzD; pfam14120 766760003374 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 766760003375 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 766760003376 Walker A/P-loop; other site 766760003377 ATP binding site [chemical binding]; other site 766760003378 Q-loop/lid; other site 766760003379 ABC transporter signature motif; other site 766760003380 Walker B; other site 766760003381 D-loop; other site 766760003382 H-loop/switch region; other site 766760003383 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 766760003384 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 766760003385 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 766760003386 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 766760003387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 766760003388 active site 766760003389 metal binding site [ion binding]; metal-binding site 766760003390 DNA binding site [nucleotide binding] 766760003391 Uncharacterized conserved protein [Function unknown]; Region: COG4717 766760003392 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 766760003393 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 766760003394 generic binding surface II; other site 766760003395 generic binding surface I; other site 766760003396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760003397 Zn2+ binding site [ion binding]; other site 766760003398 Mg2+ binding site [ion binding]; other site 766760003399 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 766760003400 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 766760003401 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 766760003402 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 766760003403 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 766760003404 transcriptional regulator Hpr; Provisional; Region: PRK13777 766760003405 MarR family; Region: MarR; pfam01047 766760003406 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 766760003407 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 766760003408 homodimer interface [polypeptide binding]; other site 766760003409 substrate-cofactor binding pocket; other site 766760003410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003411 catalytic residue [active] 766760003412 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 766760003413 HIT family signature motif; other site 766760003414 catalytic residue [active] 766760003415 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 766760003416 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760003417 Walker A/P-loop; other site 766760003418 ATP binding site [chemical binding]; other site 766760003419 Q-loop/lid; other site 766760003420 ABC transporter signature motif; other site 766760003421 Walker B; other site 766760003422 D-loop; other site 766760003423 H-loop/switch region; other site 766760003424 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 766760003425 EcsC protein family; Region: EcsC; pfam12787 766760003426 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 766760003427 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 766760003428 metal binding site [ion binding]; metal-binding site 766760003429 dimer interface [polypeptide binding]; other site 766760003430 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 766760003431 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 766760003432 Transglycosylase; Region: Transgly; pfam00912 766760003433 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 766760003434 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760003435 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 766760003436 substrate binding site [chemical binding]; other site 766760003437 active site 766760003438 ferrochelatase; Provisional; Region: PRK12435 766760003439 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 766760003440 C-terminal domain interface [polypeptide binding]; other site 766760003441 active site 766760003442 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 766760003443 active site 766760003444 N-terminal domain interface [polypeptide binding]; other site 766760003445 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 766760003446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 766760003447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760003448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760003449 Predicted membrane protein [Function unknown]; Region: COG1511 766760003450 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 766760003451 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 766760003452 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 766760003453 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 766760003454 dimer interface [polypeptide binding]; other site 766760003455 active site 766760003456 CoA binding pocket [chemical binding]; other site 766760003457 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 766760003458 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 766760003459 putative oligomer interface [polypeptide binding]; other site 766760003460 putative active site [active] 766760003461 metal binding site [ion binding]; metal-binding site 766760003462 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 766760003463 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 766760003464 YhfH-like protein; Region: YhfH; pfam14149 766760003465 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 766760003466 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 766760003467 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 766760003468 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 766760003469 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 766760003470 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 766760003471 acyl-activating enzyme (AAE) consensus motif; other site 766760003472 putative AMP binding site [chemical binding]; other site 766760003473 putative active site [active] 766760003474 putative CoA binding site [chemical binding]; other site 766760003475 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760003476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760003477 non-specific DNA binding site [nucleotide binding]; other site 766760003478 salt bridge; other site 766760003479 sequence-specific DNA binding site [nucleotide binding]; other site 766760003480 Cupin domain; Region: Cupin_2; pfam07883 766760003481 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 766760003482 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 766760003483 Peptidase family M48; Region: Peptidase_M48; pfam01435 766760003484 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 766760003485 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 766760003486 active site 766760003487 catalytic residues [active] 766760003488 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 766760003489 EamA-like transporter family; Region: EamA; pfam00892 766760003490 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 766760003491 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 766760003492 siderophore binding site; other site 766760003493 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 766760003494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760003495 ABC-ATPase subunit interface; other site 766760003496 dimer interface [polypeptide binding]; other site 766760003497 putative PBP binding regions; other site 766760003498 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 766760003499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760003500 ABC-ATPase subunit interface; other site 766760003501 dimer interface [polypeptide binding]; other site 766760003502 putative PBP binding regions; other site 766760003503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 766760003504 catalytic core [active] 766760003505 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 766760003506 heme-binding site [chemical binding]; other site 766760003507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760003508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760003509 dimer interface [polypeptide binding]; other site 766760003510 putative CheW interface [polypeptide binding]; other site 766760003511 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 766760003512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 766760003513 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 766760003514 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 766760003515 [2Fe-2S] cluster binding site [ion binding]; other site 766760003516 short chain dehydrogenase; Provisional; Region: PRK06701 766760003517 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 766760003518 NAD binding site [chemical binding]; other site 766760003519 metal binding site [ion binding]; metal-binding site 766760003520 active site 766760003521 A short protein domain of unknown function; Region: IDEAL; smart00914 766760003522 ComK protein; Region: ComK; pfam06338 766760003523 Uncharacterized conserved protein [Function unknown]; Region: COG0398 766760003524 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 766760003525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 766760003526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 766760003527 Catalytic site [active] 766760003528 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 766760003529 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 766760003530 active site 766760003531 catalytic residues [active] 766760003532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760003533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760003534 putative substrate translocation pore; other site 766760003535 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 766760003536 DRTGG domain; Region: DRTGG; pfam07085 766760003537 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 766760003538 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 766760003539 allantoinase; Provisional; Region: PRK08044 766760003540 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 766760003541 active site 766760003542 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 766760003543 allantoate amidohydrolase; Region: AllC; TIGR03176 766760003544 active site 766760003545 metal binding site [ion binding]; metal-binding site 766760003546 dimer interface [polypeptide binding]; other site 766760003547 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 766760003548 Cupin domain; Region: Cupin_2; pfam07883 766760003549 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 766760003550 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 766760003551 membrane protein FdrA; Validated; Region: PRK06091 766760003552 CoA binding domain; Region: CoA_binding; pfam02629 766760003553 CoA-ligase; Region: Ligase_CoA; pfam00549 766760003554 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 766760003555 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 766760003556 carbamate kinase; Reviewed; Region: PRK12686 766760003557 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 766760003558 putative substrate binding site [chemical binding]; other site 766760003559 nucleotide binding site [chemical binding]; other site 766760003560 nucleotide binding site [chemical binding]; other site 766760003561 homodimer interface [polypeptide binding]; other site 766760003562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760003563 D-galactonate transporter; Region: 2A0114; TIGR00893 766760003564 putative substrate translocation pore; other site 766760003565 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 766760003566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760003567 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 766760003568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760003569 DNA binding site [nucleotide binding] 766760003570 domain linker motif; other site 766760003571 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 766760003572 putative dimerization interface [polypeptide binding]; other site 766760003573 putative ligand binding site [chemical binding]; other site 766760003574 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760003575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760003576 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 766760003577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003578 dimer interface [polypeptide binding]; other site 766760003579 conserved gate region; other site 766760003580 putative PBP binding loops; other site 766760003581 ABC-ATPase subunit interface; other site 766760003582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760003583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003584 dimer interface [polypeptide binding]; other site 766760003585 conserved gate region; other site 766760003586 putative PBP binding loops; other site 766760003587 ABC-ATPase subunit interface; other site 766760003588 alpha-galactosidase; Provisional; Region: PRK15076 766760003589 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 766760003590 NAD binding site [chemical binding]; other site 766760003591 sugar binding site [chemical binding]; other site 766760003592 divalent metal binding site [ion binding]; other site 766760003593 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760003594 dimer interface [polypeptide binding]; other site 766760003595 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 766760003596 Putative ammonia monooxygenase; Region: AmoA; pfam05145 766760003597 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 766760003598 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 766760003599 CotJB protein; Region: CotJB; pfam12652 766760003600 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 766760003601 dimanganese center [ion binding]; other site 766760003602 AMP-binding domain protein; Validated; Region: PRK08315 766760003603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 766760003604 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 766760003605 acyl-activating enzyme (AAE) consensus motif; other site 766760003606 putative AMP binding site [chemical binding]; other site 766760003607 putative active site [active] 766760003608 putative CoA binding site [chemical binding]; other site 766760003609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760003610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760003611 putative substrate translocation pore; other site 766760003612 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 766760003613 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 766760003614 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 766760003615 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760003616 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 766760003617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760003618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760003619 dimerization interface [polypeptide binding]; other site 766760003620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760003621 dimer interface [polypeptide binding]; other site 766760003622 phosphorylation site [posttranslational modification] 766760003623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760003624 ATP binding site [chemical binding]; other site 766760003625 Mg2+ binding site [ion binding]; other site 766760003626 G-X-G motif; other site 766760003627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760003628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760003629 active site 766760003630 phosphorylation site [posttranslational modification] 766760003631 intermolecular recognition site; other site 766760003632 dimerization interface [polypeptide binding]; other site 766760003633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760003634 DNA binding site [nucleotide binding] 766760003635 Transposase domain (DUF772); Region: DUF772; pfam05598 766760003636 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760003637 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760003638 Uncharacterized conserved protein [Function unknown]; Region: COG1633 766760003639 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 766760003640 dinuclear metal binding motif [ion binding]; other site 766760003641 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 766760003642 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 766760003643 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 766760003644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003645 dimer interface [polypeptide binding]; other site 766760003646 conserved gate region; other site 766760003647 putative PBP binding loops; other site 766760003648 ABC-ATPase subunit interface; other site 766760003649 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 766760003650 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 766760003651 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 766760003652 Part of AAA domain; Region: AAA_19; pfam13245 766760003653 Family description; Region: UvrD_C_2; pfam13538 766760003654 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 766760003655 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 766760003656 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 766760003657 active site 766760003658 metal binding site [ion binding]; metal-binding site 766760003659 DNA binding site [nucleotide binding] 766760003660 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 766760003661 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 766760003662 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 766760003663 Walker A/P-loop; other site 766760003664 ATP binding site [chemical binding]; other site 766760003665 Q-loop/lid; other site 766760003666 ABC transporter signature motif; other site 766760003667 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 766760003668 ABC transporter signature motif; other site 766760003669 Walker B; other site 766760003670 D-loop; other site 766760003671 H-loop/switch region; other site 766760003672 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 766760003673 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 766760003674 Spore germination protein GerPC; Region: GerPC; pfam10737 766760003675 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 766760003676 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 766760003677 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 766760003678 CotH protein; Region: CotH; pfam08757 766760003679 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 766760003680 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 766760003681 GTPase RsgA; Reviewed; Region: PRK01889 766760003682 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 766760003683 RNA binding site [nucleotide binding]; other site 766760003684 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 766760003685 GTPase/Zn-binding domain interface [polypeptide binding]; other site 766760003686 GTP/Mg2+ binding site [chemical binding]; other site 766760003687 G4 box; other site 766760003688 G5 box; other site 766760003689 G1 box; other site 766760003690 Switch I region; other site 766760003691 G2 box; other site 766760003692 G3 box; other site 766760003693 Switch II region; other site 766760003694 hypothetical protein; Provisional; Region: PRK13673 766760003695 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 766760003696 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 766760003697 active site 766760003698 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 766760003699 dimer interface [polypeptide binding]; other site 766760003700 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 766760003701 Ligand Binding Site [chemical binding]; other site 766760003702 Molecular Tunnel; other site 766760003703 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 766760003704 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 766760003705 Nitrogen regulatory protein P-II; Region: P-II; smart00938 766760003706 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 766760003707 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 766760003708 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 766760003709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760003710 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760003711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760003712 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760003713 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 766760003714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760003715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760003716 DNA binding site [nucleotide binding] 766760003717 domain linker motif; other site 766760003718 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 766760003719 dimerization interface [polypeptide binding]; other site 766760003720 ligand binding site [chemical binding]; other site 766760003721 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760003722 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760003723 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 766760003724 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 766760003725 ATP P2X receptor; Region: P2X_receptor; cl02993 766760003726 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 766760003727 Spore germination protein; Region: Spore_permease; cl17796 766760003728 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 766760003729 Lysine efflux permease [General function prediction only]; Region: COG1279 766760003730 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 766760003731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760003732 DNA-binding site [nucleotide binding]; DNA binding site 766760003733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760003734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003735 homodimer interface [polypeptide binding]; other site 766760003736 catalytic residue [active] 766760003737 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 766760003738 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760003739 inhibitor-cofactor binding pocket; inhibition site 766760003740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003741 catalytic residue [active] 766760003742 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 766760003743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003744 catalytic residue [active] 766760003745 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 766760003746 IucA / IucC family; Region: IucA_IucC; pfam04183 766760003747 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 766760003748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 766760003749 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 766760003750 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 766760003751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760003752 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 766760003753 IucA / IucC family; Region: IucA_IucC; pfam04183 766760003754 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 766760003755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 766760003756 Coenzyme A binding pocket [chemical binding]; other site 766760003757 short chain dehydrogenase; Provisional; Region: PRK08303 766760003758 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs; Region: DHRS1-like_SDR_c; cd09763 766760003759 NAD(P) binding site [chemical binding]; other site 766760003760 putative dimer interface [polypeptide binding]; other site 766760003761 active site 766760003762 Predicted transcriptional regulator [Transcription]; Region: COG2378 766760003763 HTH domain; Region: HTH_11; pfam08279 766760003764 WYL domain; Region: WYL; pfam13280 766760003765 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 766760003766 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 766760003767 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 766760003768 substrate binding pocket [chemical binding]; other site 766760003769 dimer interface [polypeptide binding]; other site 766760003770 inhibitor binding site; inhibition site 766760003771 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 766760003772 B12 binding site [chemical binding]; other site 766760003773 cobalt ligand [ion binding]; other site 766760003774 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 766760003775 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 766760003776 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 766760003777 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 766760003778 FAD binding site [chemical binding]; other site 766760003779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 766760003780 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 766760003781 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 766760003782 S1 domain; Region: S1_2; pfam13509 766760003783 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 766760003784 RNA binding site [nucleotide binding]; other site 766760003785 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 766760003786 EDD domain protein, DegV family; Region: DegV; TIGR00762 766760003787 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 766760003788 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760003789 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760003790 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760003791 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760003792 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 766760003793 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 766760003794 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 766760003795 active site 766760003796 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 766760003797 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 766760003798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760003799 motif II; other site 766760003800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760003801 esterase; Provisional; Region: PRK10566 766760003802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760003803 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 766760003804 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 766760003805 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 766760003806 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 766760003807 heterotetramer interface [polypeptide binding]; other site 766760003808 active site pocket [active] 766760003809 cleavage site 766760003810 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 766760003811 nucleotide binding site [chemical binding]; other site 766760003812 N-acetyl-L-glutamate binding site [chemical binding]; other site 766760003813 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 766760003814 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760003815 inhibitor-cofactor binding pocket; inhibition site 766760003816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760003817 catalytic residue [active] 766760003818 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 766760003819 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 766760003820 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 766760003821 catalytic site [active] 766760003822 subunit interface [polypeptide binding]; other site 766760003823 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 766760003824 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760003825 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 766760003826 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 766760003827 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760003828 ATP-grasp domain; Region: ATP-grasp_4; cl17255 766760003829 ornithine carbamoyltransferase; Provisional; Region: PRK00779 766760003830 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 766760003831 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 766760003832 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 766760003833 YjzC-like protein; Region: YjzC; pfam14168 766760003834 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 766760003835 LytB protein; Region: LYTB; cl00507 766760003836 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 766760003837 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 766760003838 putative ligand binding site [chemical binding]; other site 766760003839 ComZ; Region: ComZ; pfam10815 766760003840 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 766760003841 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 766760003842 dimer interface [polypeptide binding]; other site 766760003843 active site 766760003844 CoA binding pocket [chemical binding]; other site 766760003845 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 766760003846 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 766760003847 dimer interface [polypeptide binding]; other site 766760003848 active site 766760003849 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 766760003850 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 766760003851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760003852 Walker A/P-loop; other site 766760003853 ATP binding site [chemical binding]; other site 766760003854 Q-loop/lid; other site 766760003855 ABC transporter signature motif; other site 766760003856 Walker B; other site 766760003857 D-loop; other site 766760003858 H-loop/switch region; other site 766760003859 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 766760003860 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 766760003861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760003862 Walker A/P-loop; other site 766760003863 ATP binding site [chemical binding]; other site 766760003864 Q-loop/lid; other site 766760003865 ABC transporter signature motif; other site 766760003866 Walker B; other site 766760003867 D-loop; other site 766760003868 H-loop/switch region; other site 766760003869 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 766760003870 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 766760003871 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 766760003872 peptide binding site [polypeptide binding]; other site 766760003873 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 766760003874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003875 dimer interface [polypeptide binding]; other site 766760003876 conserved gate region; other site 766760003877 putative PBP binding loops; other site 766760003878 ABC-ATPase subunit interface; other site 766760003879 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 766760003880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003881 dimer interface [polypeptide binding]; other site 766760003882 conserved gate region; other site 766760003883 putative PBP binding loops; other site 766760003884 ABC-ATPase subunit interface; other site 766760003885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760003886 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760003887 putative substrate translocation pore; other site 766760003888 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 766760003889 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 766760003890 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 766760003891 active site 766760003892 HIGH motif; other site 766760003893 dimer interface [polypeptide binding]; other site 766760003894 KMSKS motif; other site 766760003895 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 766760003896 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 766760003897 peptide binding site [polypeptide binding]; other site 766760003898 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 766760003899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003900 dimer interface [polypeptide binding]; other site 766760003901 conserved gate region; other site 766760003902 putative PBP binding loops; other site 766760003903 ABC-ATPase subunit interface; other site 766760003904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 766760003905 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 766760003906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760003907 dimer interface [polypeptide binding]; other site 766760003908 conserved gate region; other site 766760003909 putative PBP binding loops; other site 766760003910 ABC-ATPase subunit interface; other site 766760003911 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 766760003912 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760003913 Walker A/P-loop; other site 766760003914 ATP binding site [chemical binding]; other site 766760003915 Q-loop/lid; other site 766760003916 ABC transporter signature motif; other site 766760003917 Walker B; other site 766760003918 D-loop; other site 766760003919 H-loop/switch region; other site 766760003920 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 766760003921 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 766760003922 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760003923 Walker A/P-loop; other site 766760003924 ATP binding site [chemical binding]; other site 766760003925 Q-loop/lid; other site 766760003926 ABC transporter signature motif; other site 766760003927 Walker B; other site 766760003928 D-loop; other site 766760003929 H-loop/switch region; other site 766760003930 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 766760003931 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 766760003932 ArsC family; Region: ArsC; pfam03960 766760003933 putative catalytic residues [active] 766760003934 thiol/disulfide switch; other site 766760003935 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 766760003936 adaptor protein; Provisional; Region: PRK02315 766760003937 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 766760003938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 766760003939 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 766760003940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 766760003941 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 766760003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760003943 active site 766760003944 phosphorylation site [posttranslational modification] 766760003945 intermolecular recognition site; other site 766760003946 dimerization interface [polypeptide binding]; other site 766760003947 Transcriptional regulator; Region: CitT; pfam12431 766760003948 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 766760003949 PAS domain; Region: PAS; smart00091 766760003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760003951 ATP binding site [chemical binding]; other site 766760003952 Mg2+ binding site [ion binding]; other site 766760003953 G-X-G motif; other site 766760003954 Competence protein CoiA-like family; Region: CoiA; cl11541 766760003955 oligoendopeptidase F; Region: pepF; TIGR00181 766760003956 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 766760003957 active site 766760003958 Zn binding site [ion binding]; other site 766760003959 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 766760003960 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 766760003961 catalytic residues [active] 766760003962 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 766760003963 apolar tunnel; other site 766760003964 heme binding site [chemical binding]; other site 766760003965 dimerization interface [polypeptide binding]; other site 766760003966 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 766760003967 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 766760003968 N-acetyl-D-glucosamine binding site [chemical binding]; other site 766760003969 catalytic residue [active] 766760003970 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 766760003971 putative active site [active] 766760003972 putative metal binding residues [ion binding]; other site 766760003973 signature motif; other site 766760003974 putative triphosphate binding site [ion binding]; other site 766760003975 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 766760003976 synthetase active site [active] 766760003977 NTP binding site [chemical binding]; other site 766760003978 metal binding site [ion binding]; metal-binding site 766760003979 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 766760003980 ATP-NAD kinase; Region: NAD_kinase; pfam01513 766760003981 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 766760003982 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 766760003983 active site 766760003984 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 766760003985 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 766760003986 active site 766760003987 metal binding site [ion binding]; metal-binding site 766760003988 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 766760003989 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 766760003990 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 766760003991 TrkA-N domain; Region: TrkA_N; pfam02254 766760003992 TrkA-C domain; Region: TrkA_C; pfam02080 766760003993 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 766760003994 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 766760003995 thiamine phosphate binding site [chemical binding]; other site 766760003996 active site 766760003997 pyrophosphate binding site [ion binding]; other site 766760003998 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 766760003999 hydroxyglutarate oxidase; Provisional; Region: PRK11728 766760004000 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 766760004001 thiS-thiF/thiG interaction site; other site 766760004002 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 766760004003 ThiS interaction site; other site 766760004004 putative active site [active] 766760004005 tetramer interface [polypeptide binding]; other site 766760004006 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 766760004007 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 766760004008 ATP binding site [chemical binding]; other site 766760004009 substrate interface [chemical binding]; other site 766760004010 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 766760004011 dimer interface [polypeptide binding]; other site 766760004012 substrate binding site [chemical binding]; other site 766760004013 ATP binding site [chemical binding]; other site 766760004014 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 766760004015 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 766760004016 NAD binding site [chemical binding]; other site 766760004017 homotetramer interface [polypeptide binding]; other site 766760004018 homodimer interface [polypeptide binding]; other site 766760004019 substrate binding site [chemical binding]; other site 766760004020 active site 766760004021 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 766760004022 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 766760004023 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 766760004024 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 766760004025 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 766760004026 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 766760004027 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 766760004028 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 766760004029 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 766760004030 Part of AAA domain; Region: AAA_19; pfam13245 766760004031 Family description; Region: UvrD_C_2; pfam13538 766760004032 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 766760004033 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 766760004034 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 766760004035 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 766760004036 NAD binding site [chemical binding]; other site 766760004037 homodimer interface [polypeptide binding]; other site 766760004038 active site 766760004039 substrate binding site [chemical binding]; other site 766760004040 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 766760004041 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 766760004042 active site 766760004043 tetramer interface; other site 766760004044 Predicted membrane protein [Function unknown]; Region: COG2246 766760004045 GtrA-like protein; Region: GtrA; pfam04138 766760004046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760004047 Coenzyme A binding pocket [chemical binding]; other site 766760004048 hypothetical protein; Provisional; Region: PRK13679 766760004049 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 766760004050 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 766760004051 Putative esterase; Region: Esterase; pfam00756 766760004052 Pathogenicity locus; Region: Cdd1; pfam11731 766760004053 DinB superfamily; Region: DinB_2; pfam12867 766760004054 DinB family; Region: DinB; cl17821 766760004055 Predicted transcriptional regulator [Transcription]; Region: COG2378 766760004056 HTH domain; Region: HTH_11; pfam08279 766760004057 WYL domain; Region: WYL; pfam13280 766760004058 cystathionine gamma-synthase; Reviewed; Region: PRK08247 766760004059 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 766760004060 homodimer interface [polypeptide binding]; other site 766760004061 substrate-cofactor binding pocket; other site 766760004062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760004063 catalytic residue [active] 766760004064 cystathionine beta-lyase; Provisional; Region: PRK08064 766760004065 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 766760004066 homodimer interface [polypeptide binding]; other site 766760004067 substrate-cofactor binding pocket; other site 766760004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760004069 catalytic residue [active] 766760004070 Predicted integral membrane protein [Function unknown]; Region: COG5505 766760004071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760004072 MarR family; Region: MarR_2; pfam12802 766760004073 MarR family; Region: MarR_2; cl17246 766760004074 Beta-lactamase; Region: Beta-lactamase; pfam00144 766760004075 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 766760004076 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 766760004077 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 766760004078 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 766760004079 substrate binding site [chemical binding]; other site 766760004080 active site 766760004081 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 766760004082 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 766760004083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760004084 salt bridge; other site 766760004085 non-specific DNA binding site [nucleotide binding]; other site 766760004086 sequence-specific DNA binding site [nucleotide binding]; other site 766760004087 Haemolysin XhlA; Region: XhlA; pfam10779 766760004088 holin, SPP1 family; Region: holin_SPP1; TIGR01592 766760004089 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 766760004090 amidase catalytic site [active] 766760004091 Zn binding residues [ion binding]; other site 766760004092 substrate binding site [chemical binding]; other site 766760004093 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 766760004094 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760004095 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760004096 GAF domain; Region: GAF; pfam01590 766760004097 YolD-like protein; Region: YolD; pfam08863 766760004098 maltose O-acetyltransferase; Provisional; Region: PRK10092 766760004099 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 766760004100 active site 766760004101 substrate binding site [chemical binding]; other site 766760004102 trimer interface [polypeptide binding]; other site 766760004103 CoA binding site [chemical binding]; other site 766760004104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760004105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760004106 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 766760004107 putative dimerization interface [polypeptide binding]; other site 766760004108 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 766760004109 Flavodoxin; Region: Flavodoxin_1; pfam00258 766760004110 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 766760004111 FAD binding pocket [chemical binding]; other site 766760004112 FAD binding motif [chemical binding]; other site 766760004113 catalytic residues [active] 766760004114 NAD binding pocket [chemical binding]; other site 766760004115 phosphate binding motif [ion binding]; other site 766760004116 beta-alpha-beta structure motif; other site 766760004117 sulfite reductase subunit beta; Provisional; Region: PRK13504 766760004118 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 766760004119 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 766760004120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760004121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760004122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760004123 dimerization interface [polypeptide binding]; other site 766760004124 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 766760004125 EamA-like transporter family; Region: EamA; pfam00892 766760004126 EamA-like transporter family; Region: EamA; pfam00892 766760004127 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 766760004128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760004129 putative metal binding site [ion binding]; other site 766760004130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760004131 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760004132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 766760004133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760004134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760004135 putative substrate translocation pore; other site 766760004136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760004137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760004138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760004139 Regulatory protein YrvL; Region: YrvL; pfam14184 766760004140 Protein of unknown function (DUF867); Region: DUF867; pfam05908 766760004141 Domain of unknown function (DUF955); Region: DUF955; pfam06114 766760004142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760004143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760004144 non-specific DNA binding site [nucleotide binding]; other site 766760004145 salt bridge; other site 766760004146 sequence-specific DNA binding site [nucleotide binding]; other site 766760004147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760004148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760004149 non-specific DNA binding site [nucleotide binding]; other site 766760004150 salt bridge; other site 766760004151 sequence-specific DNA binding site [nucleotide binding]; other site 766760004152 Transcriptional regulator; Region: Rrf2; cl17282 766760004153 hypothetical protein; Provisional; Region: PRK06921 766760004154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760004155 Walker A motif; other site 766760004156 ATP binding site [chemical binding]; other site 766760004157 Walker B motif; other site 766760004158 positive control sigma-like factor; Validated; Region: PRK06930 766760004159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760004160 DNA binding residues [nucleotide binding] 766760004161 Phage terminase small subunit; Region: Phage_terminase; pfam10668 766760004162 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 766760004163 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 766760004164 Terminase-like family; Region: Terminase_6; pfam03237 766760004165 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 766760004166 Phage capsid family; Region: Phage_capsid; pfam05065 766760004167 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 766760004168 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 766760004169 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 766760004170 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 766760004171 Phage XkdN-like protein; Region: XkdN; pfam08890 766760004172 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 766760004173 N-acetyl-D-glucosamine binding site [chemical binding]; other site 766760004174 catalytic residue [active] 766760004175 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 766760004176 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760004177 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 766760004178 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 766760004179 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 766760004180 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 766760004181 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 766760004182 Haemolysin XhlA; Region: XhlA; pfam10779 766760004183 holin, SPP1 family; Region: holin_SPP1; TIGR01592 766760004184 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 766760004185 Acyltransferase family; Region: Acyl_transf_3; pfam01757 766760004186 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 766760004187 amidase catalytic site [active] 766760004188 Zn binding residues [ion binding]; other site 766760004189 substrate binding site [chemical binding]; other site 766760004190 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 766760004191 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760004192 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760004193 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760004194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760004195 DNA-binding site [nucleotide binding]; DNA binding site 766760004196 FCD domain; Region: FCD; pfam07729 766760004197 putative oxidoreductase; Provisional; Region: PRK10083 766760004198 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 766760004199 putative NAD(P) binding site [chemical binding]; other site 766760004200 catalytic Zn binding site [ion binding]; other site 766760004201 structural Zn binding site [ion binding]; other site 766760004202 mannonate dehydratase; Provisional; Region: PRK03906 766760004203 mannonate dehydratase; Region: uxuA; TIGR00695 766760004204 D-mannonate oxidoreductase; Provisional; Region: PRK08277 766760004205 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 766760004206 putative NAD(P) binding site [chemical binding]; other site 766760004207 active site 766760004208 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 766760004209 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 766760004210 putative NAD(P) binding site [chemical binding]; other site 766760004211 catalytic Zn binding site [ion binding]; other site 766760004212 structural Zn binding site [ion binding]; other site 766760004213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760004214 D-galactonate transporter; Region: 2A0114; TIGR00893 766760004215 putative substrate translocation pore; other site 766760004216 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 766760004217 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 766760004218 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 766760004219 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 766760004220 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 766760004221 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 766760004222 Protein of unknown function, DUF624; Region: DUF624; cl02369 766760004223 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 766760004224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760004225 dimerization interface [polypeptide binding]; other site 766760004226 Histidine kinase; Region: His_kinase; pfam06580 766760004227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760004228 ATP binding site [chemical binding]; other site 766760004229 Mg2+ binding site [ion binding]; other site 766760004230 G-X-G motif; other site 766760004231 Response regulator receiver domain; Region: Response_reg; pfam00072 766760004232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760004233 active site 766760004234 phosphorylation site [posttranslational modification] 766760004235 intermolecular recognition site; other site 766760004236 dimerization interface [polypeptide binding]; other site 766760004237 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760004238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760004239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760004240 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760004241 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 766760004242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760004243 dimer interface [polypeptide binding]; other site 766760004244 conserved gate region; other site 766760004245 putative PBP binding loops; other site 766760004246 ABC-ATPase subunit interface; other site 766760004247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760004248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760004249 dimer interface [polypeptide binding]; other site 766760004250 conserved gate region; other site 766760004251 putative PBP binding loops; other site 766760004252 ABC-ATPase subunit interface; other site 766760004253 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 766760004254 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 766760004255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760004256 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760004257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760004258 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 766760004259 active site 766760004260 catalytic triad [active] 766760004261 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 766760004262 Predicted integral membrane protein [Function unknown]; Region: COG5578 766760004263 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 766760004264 metal binding site [ion binding]; metal-binding site 766760004265 active site 766760004266 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 766760004267 active site 766760004268 catalytic triad [active] 766760004269 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 766760004270 metal binding site [ion binding]; metal-binding site 766760004271 active site 766760004272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 766760004273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 766760004274 active site 766760004275 catalytic tetrad [active] 766760004276 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 766760004277 active site 766760004278 catalytic triad [active] 766760004279 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 766760004280 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 766760004281 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 766760004282 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 766760004283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760004284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760004285 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 766760004286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760004287 dimer interface [polypeptide binding]; other site 766760004288 conserved gate region; other site 766760004289 ABC-ATPase subunit interface; other site 766760004290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760004291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760004292 dimer interface [polypeptide binding]; other site 766760004293 conserved gate region; other site 766760004294 putative PBP binding loops; other site 766760004295 ABC-ATPase subunit interface; other site 766760004296 amino acid transporter; Region: 2A0306; TIGR00909 766760004297 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 766760004298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760004299 Zn binding site [ion binding]; other site 766760004300 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 766760004301 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760004302 Zn binding site [ion binding]; other site 766760004303 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 766760004304 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 766760004305 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 766760004306 protein binding site [polypeptide binding]; other site 766760004307 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 766760004308 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 766760004309 Transposase domain (DUF772); Region: DUF772; pfam05598 766760004310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760004311 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760004312 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 766760004313 SxDxEG motif; other site 766760004314 active site 766760004315 metal binding site [ion binding]; metal-binding site 766760004316 homopentamer interface [polypeptide binding]; other site 766760004317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 766760004318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760004319 dimer interface [polypeptide binding]; other site 766760004320 conserved gate region; other site 766760004321 putative PBP binding loops; other site 766760004322 ABC-ATPase subunit interface; other site 766760004323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 766760004324 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 766760004325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760004326 putative PBP binding loops; other site 766760004327 dimer interface [polypeptide binding]; other site 766760004328 ABC-ATPase subunit interface; other site 766760004329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 766760004330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760004331 Walker A/P-loop; other site 766760004332 ATP binding site [chemical binding]; other site 766760004333 Q-loop/lid; other site 766760004334 ABC transporter signature motif; other site 766760004335 Walker B; other site 766760004336 D-loop; other site 766760004337 H-loop/switch region; other site 766760004338 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 766760004339 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 766760004340 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 766760004341 peptide binding site [polypeptide binding]; other site 766760004342 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 766760004343 dimer interface [polypeptide binding]; other site 766760004344 catalytic triad [active] 766760004345 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 766760004346 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 766760004347 active site 766760004348 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760004349 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760004350 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 766760004351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760004352 Walker A/P-loop; other site 766760004353 ATP binding site [chemical binding]; other site 766760004354 Q-loop/lid; other site 766760004355 ABC transporter signature motif; other site 766760004356 Walker B; other site 766760004357 D-loop; other site 766760004358 H-loop/switch region; other site 766760004359 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 766760004360 Patatin-like phospholipase; Region: Patatin; pfam01734 766760004361 active site 766760004362 nucleophile elbow; other site 766760004363 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 766760004364 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 766760004365 Amidinotransferase; Region: Amidinotransf; pfam02274 766760004366 Predicted membrane protein [Function unknown]; Region: COG2323 766760004367 Amb_all domain; Region: Amb_all; smart00656 766760004368 Predicted transcriptional regulators [Transcription]; Region: COG1695 766760004369 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 766760004370 hypothetical protein; Validated; Region: PRK07668 766760004371 Protein of unknown function (DUF664); Region: DUF664; pfam04978 766760004372 DinB superfamily; Region: DinB_2; pfam12867 766760004373 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 766760004374 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 766760004375 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 766760004376 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 766760004377 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 766760004378 putative active site [active] 766760004379 putative substrate binding site [chemical binding]; other site 766760004380 putative cosubstrate binding site; other site 766760004381 catalytic site [active] 766760004382 gamma-glutamyl kinase; Provisional; Region: PRK05429 766760004383 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 766760004384 nucleotide binding site [chemical binding]; other site 766760004385 homotetrameric interface [polypeptide binding]; other site 766760004386 putative phosphate binding site [ion binding]; other site 766760004387 putative allosteric binding site; other site 766760004388 PUA domain; Region: PUA; pfam01472 766760004389 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 766760004390 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 766760004391 putative catalytic cysteine [active] 766760004392 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 766760004393 Transcriptional regulators [Transcription]; Region: MarR; COG1846 766760004394 MarR family; Region: MarR; pfam01047 766760004395 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 766760004396 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 766760004397 nucleoside/Zn binding site; other site 766760004398 dimer interface [polypeptide binding]; other site 766760004399 catalytic motif [active] 766760004400 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 766760004401 catalytic core [active] 766760004402 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 766760004403 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 766760004404 THF binding site; other site 766760004405 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 766760004406 substrate binding site [chemical binding]; other site 766760004407 THF binding site; other site 766760004408 zinc-binding site [ion binding]; other site 766760004409 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 766760004410 active site 766760004411 catalytic residues [active] 766760004412 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 766760004413 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 766760004414 MgtE intracellular N domain; Region: MgtE_N; smart00924 766760004415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 766760004416 Divalent cation transporter; Region: MgtE; pfam01769 766760004417 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 766760004418 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 766760004419 DNA binding residues [nucleotide binding] 766760004420 putative dimer interface [polypeptide binding]; other site 766760004421 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760004422 MarR family; Region: MarR; pfam01047 766760004423 MarR family; Region: MarR_2; cl17246 766760004424 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 766760004425 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 766760004426 active site 766760004427 DNA binding site [nucleotide binding] 766760004428 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 766760004429 nucleotide binding site [chemical binding]; other site 766760004430 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 766760004431 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 766760004432 putative DNA binding site [nucleotide binding]; other site 766760004433 putative homodimer interface [polypeptide binding]; other site 766760004434 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 766760004435 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 766760004436 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 766760004437 PAS domain S-box; Region: sensory_box; TIGR00229 766760004438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 766760004439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 766760004440 metal binding site [ion binding]; metal-binding site 766760004441 active site 766760004442 I-site; other site 766760004443 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 766760004444 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 766760004445 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 766760004446 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 766760004447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760004448 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 766760004449 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 766760004450 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 766760004451 heat shock protein HtpX; Provisional; Region: PRK05457 766760004452 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 766760004453 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 766760004454 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 766760004455 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 766760004456 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 766760004457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760004458 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 766760004459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004460 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 766760004461 putative active site [active] 766760004462 heme pocket [chemical binding]; other site 766760004463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004464 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 766760004465 putative active site [active] 766760004466 heme pocket [chemical binding]; other site 766760004467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004468 putative active site [active] 766760004469 heme pocket [chemical binding]; other site 766760004470 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 766760004471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760004472 dimer interface [polypeptide binding]; other site 766760004473 phosphorylation site [posttranslational modification] 766760004474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760004475 ATP binding site [chemical binding]; other site 766760004476 Mg2+ binding site [ion binding]; other site 766760004477 G-X-G motif; other site 766760004478 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 766760004479 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 766760004480 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 766760004481 DNA binding site [nucleotide binding] 766760004482 active site 766760004483 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 766760004484 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 766760004485 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 766760004486 Phosphotransferase enzyme family; Region: APH; pfam01636 766760004487 Predicted amidohydrolase [General function prediction only]; Region: COG0388 766760004488 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 766760004489 putative active site [active] 766760004490 catalytic triad [active] 766760004491 putative dimer interface [polypeptide binding]; other site 766760004492 transaminase; Reviewed; Region: PRK08068 766760004493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760004494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760004495 homodimer interface [polypeptide binding]; other site 766760004496 catalytic residue [active] 766760004497 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 766760004498 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 766760004499 dimer interface [polypeptide binding]; other site 766760004500 active site 766760004501 catalytic residue [active] 766760004502 metal binding site [ion binding]; metal-binding site 766760004503 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 766760004504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760004505 motif II; other site 766760004506 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 766760004507 intersubunit interface [polypeptide binding]; other site 766760004508 active site 766760004509 Zn2+ binding site [ion binding]; other site 766760004510 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 766760004511 Cupin domain; Region: Cupin_2; pfam07883 766760004512 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 766760004513 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 766760004514 active site 766760004515 metal binding site [ion binding]; metal-binding site 766760004516 Uncharacterized conserved protein [Function unknown]; Region: COG3339 766760004517 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 766760004518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760004519 dimer interface [polypeptide binding]; other site 766760004520 phosphorylation site [posttranslational modification] 766760004521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760004522 ATP binding site [chemical binding]; other site 766760004523 Mg2+ binding site [ion binding]; other site 766760004524 G-X-G motif; other site 766760004525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760004526 MarR family; Region: MarR; pfam01047 766760004527 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 766760004528 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 766760004529 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 766760004530 ligand binding site [chemical binding]; other site 766760004531 flagellar motor protein MotA; Validated; Region: PRK08124 766760004532 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 766760004533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760004534 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760004535 Walker A motif; other site 766760004536 ATP binding site [chemical binding]; other site 766760004537 Walker B motif; other site 766760004538 arginine finger; other site 766760004539 UvrB/uvrC motif; Region: UVR; pfam02151 766760004540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760004541 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760004542 Walker A motif; other site 766760004543 ATP binding site [chemical binding]; other site 766760004544 Walker B motif; other site 766760004545 arginine finger; other site 766760004546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 766760004547 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 766760004548 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 766760004549 Ligand Binding Site [chemical binding]; other site 766760004550 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 766760004551 active site 766760004552 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 766760004553 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 766760004554 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 766760004555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760004556 binding surface 766760004557 TPR motif; other site 766760004558 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760004559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760004560 TPR motif; other site 766760004561 binding surface 766760004562 NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00137 766760004563 Protein of unknown function (DUF817); Region: DUF817; pfam05675 766760004564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760004565 salt bridge; other site 766760004566 non-specific DNA binding site [nucleotide binding]; other site 766760004567 sequence-specific DNA binding site [nucleotide binding]; other site 766760004568 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 766760004569 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 766760004570 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 766760004571 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 766760004572 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 766760004573 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 766760004574 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 766760004575 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 766760004576 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 766760004577 catalytic residues [active] 766760004578 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 766760004579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 766760004580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760004581 motif II; other site 766760004582 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 766760004583 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 766760004584 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 766760004585 active site 766760004586 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 766760004587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760004588 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760004589 DNA binding site [nucleotide binding] 766760004590 domain linker motif; other site 766760004591 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 766760004592 putative dimerization interface [polypeptide binding]; other site 766760004593 putative ligand binding site [chemical binding]; other site 766760004594 CAT RNA binding domain; Region: CAT_RBD; smart01061 766760004595 transcriptional antiterminator BglG; Provisional; Region: PRK09772 766760004596 PRD domain; Region: PRD; pfam00874 766760004597 PRD domain; Region: PRD; pfam00874 766760004598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760004599 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 766760004600 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760004601 active site turn [active] 766760004602 phosphorylation site [posttranslational modification] 766760004603 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 766760004604 HPr interaction site; other site 766760004605 glycerol kinase (GK) interaction site [polypeptide binding]; other site 766760004606 active site 766760004607 phosphorylation site [posttranslational modification] 766760004608 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 766760004609 dimerization domain swap beta strand [polypeptide binding]; other site 766760004610 regulatory protein interface [polypeptide binding]; other site 766760004611 active site 766760004612 regulatory phosphorylation site [posttranslational modification]; other site 766760004613 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 766760004614 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 766760004615 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 766760004616 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 766760004617 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 766760004618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760004619 FeS/SAM binding site; other site 766760004620 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 766760004621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760004622 Coenzyme A binding pocket [chemical binding]; other site 766760004623 Cache domain; Region: Cache_1; pfam02743 766760004624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760004625 dimerization interface [polypeptide binding]; other site 766760004626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760004627 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760004628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760004629 dimer interface [polypeptide binding]; other site 766760004630 putative CheW interface [polypeptide binding]; other site 766760004631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 766760004632 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 766760004633 putative NAD(P) binding site [chemical binding]; other site 766760004634 putative active site [active] 766760004635 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 766760004636 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 766760004637 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 766760004638 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 766760004639 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 766760004640 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 766760004641 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760004642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004643 PAS fold; Region: PAS_3; pfam08447 766760004644 putative active site [active] 766760004645 heme pocket [chemical binding]; other site 766760004646 PAS fold; Region: PAS; pfam00989 766760004647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004648 putative active site [active] 766760004649 heme pocket [chemical binding]; other site 766760004650 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 766760004651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004652 putative active site [active] 766760004653 heme pocket [chemical binding]; other site 766760004654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760004655 dimer interface [polypeptide binding]; other site 766760004656 phosphorylation site [posttranslational modification] 766760004657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760004658 ATP binding site [chemical binding]; other site 766760004659 Mg2+ binding site [ion binding]; other site 766760004660 G-X-G motif; other site 766760004661 aminotransferase A; Validated; Region: PRK07683 766760004662 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760004663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760004664 homodimer interface [polypeptide binding]; other site 766760004665 catalytic residue [active] 766760004666 RDD family; Region: RDD; pfam06271 766760004667 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 766760004668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760004669 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 766760004670 putative CheA interaction surface; other site 766760004671 Response regulator receiver domain; Region: Response_reg; pfam00072 766760004672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760004673 active site 766760004674 phosphorylation site [posttranslational modification] 766760004675 intermolecular recognition site; other site 766760004676 dimerization interface [polypeptide binding]; other site 766760004677 YkyB-like protein; Region: YkyB; pfam14177 766760004678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760004679 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760004680 putative substrate translocation pore; other site 766760004681 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760004682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 766760004683 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 766760004684 phosphodiesterase YaeI; Provisional; Region: PRK11340 766760004685 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 766760004686 putative active site [active] 766760004687 putative metal binding site [ion binding]; other site 766760004688 short chain dehydrogenase; Provisional; Region: PRK07677 766760004689 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 766760004690 NAD(P) binding site [chemical binding]; other site 766760004691 substrate binding site [chemical binding]; other site 766760004692 homotetramer interface [polypeptide binding]; other site 766760004693 active site 766760004694 homodimer interface [polypeptide binding]; other site 766760004695 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 766760004696 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 766760004697 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 766760004698 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 766760004699 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 766760004700 Protein of unknown function (DUF458); Region: DUF458; pfam04308 766760004701 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 766760004702 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 766760004703 FOG: CBS domain [General function prediction only]; Region: COG0517 766760004704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760004705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760004706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760004707 dimerization interface [polypeptide binding]; other site 766760004708 flavodoxin; Provisional; Region: PRK06703 766760004709 BNR repeat-like domain; Region: BNR_2; pfam13088 766760004710 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 766760004711 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 766760004712 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 766760004713 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 766760004714 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 766760004715 active site 766760004716 trimer interface [polypeptide binding]; other site 766760004717 substrate binding site [chemical binding]; other site 766760004718 CoA binding site [chemical binding]; other site 766760004719 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 766760004720 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 766760004721 metal binding site [ion binding]; metal-binding site 766760004722 putative dimer interface [polypeptide binding]; other site 766760004723 hypothetical protein; Provisional; Region: PRK03094 766760004724 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 766760004725 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 766760004726 dimer interface [polypeptide binding]; other site 766760004727 decamer (pentamer of dimers) interface [polypeptide binding]; other site 766760004728 catalytic triad [active] 766760004729 peroxidatic and resolving cysteines [active] 766760004730 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 766760004731 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 766760004732 catalytic residues [active] 766760004733 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 766760004734 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 766760004735 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 766760004736 GTP binding site; other site 766760004737 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 766760004738 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 766760004739 ATP binding site [chemical binding]; other site 766760004740 substrate interface [chemical binding]; other site 766760004741 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 766760004742 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 766760004743 dimer interface [polypeptide binding]; other site 766760004744 putative functional site; other site 766760004745 putative MPT binding site; other site 766760004746 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 766760004747 Walker A motif; other site 766760004748 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 766760004749 MoaE homodimer interface [polypeptide binding]; other site 766760004750 MoaD interaction [polypeptide binding]; other site 766760004751 active site residues [active] 766760004752 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 766760004753 MoaE interaction surface [polypeptide binding]; other site 766760004754 MoeB interaction surface [polypeptide binding]; other site 766760004755 thiocarboxylated glycine; other site 766760004756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760004757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760004758 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 766760004759 Walker A/P-loop; other site 766760004760 ATP binding site [chemical binding]; other site 766760004761 Q-loop/lid; other site 766760004762 ABC transporter signature motif; other site 766760004763 Walker B; other site 766760004764 D-loop; other site 766760004765 H-loop/switch region; other site 766760004766 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760004767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760004768 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 766760004769 Walker A/P-loop; other site 766760004770 ATP binding site [chemical binding]; other site 766760004771 Q-loop/lid; other site 766760004772 ABC transporter signature motif; other site 766760004773 Walker B; other site 766760004774 D-loop; other site 766760004775 H-loop/switch region; other site 766760004776 Yip1 domain; Region: Yip1; pfam04893 766760004777 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 766760004778 HlyD family secretion protein; Region: HlyD_3; pfam13437 766760004779 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760004780 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760004781 Walker A/P-loop; other site 766760004782 ATP binding site [chemical binding]; other site 766760004783 Q-loop/lid; other site 766760004784 ABC transporter signature motif; other site 766760004785 Walker B; other site 766760004786 D-loop; other site 766760004787 H-loop/switch region; other site 766760004788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 766760004789 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 766760004790 FtsX-like permease family; Region: FtsX; pfam02687 766760004791 Yip1 domain; Region: Yip1; pfam04893 766760004792 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 766760004793 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 766760004794 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 766760004795 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 766760004796 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 766760004797 putative substrate binding site [chemical binding]; other site 766760004798 putative ATP binding site [chemical binding]; other site 766760004799 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 766760004800 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760004801 active site 766760004802 phosphorylation site [posttranslational modification] 766760004803 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 766760004804 active site 766760004805 P-loop; other site 766760004806 phosphorylation site [posttranslational modification] 766760004807 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 766760004808 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 766760004809 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 766760004810 Catalytic site [active] 766760004811 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 766760004812 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 766760004813 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760004814 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760004815 ABC transporter; Region: ABC_tran_2; pfam12848 766760004816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760004817 SnoaL-like domain; Region: SnoaL_3; pfam13474 766760004818 SnoaL-like domain; Region: SnoaL_2; pfam12680 766760004819 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 766760004820 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 766760004821 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 766760004822 rod-share determining protein MreBH; Provisional; Region: PRK13929 766760004823 MreB and similar proteins; Region: MreB_like; cd10225 766760004824 nucleotide binding site [chemical binding]; other site 766760004825 Mg binding site [ion binding]; other site 766760004826 putative protofilament interaction site [polypeptide binding]; other site 766760004827 RodZ interaction site [polypeptide binding]; other site 766760004828 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 766760004829 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 766760004830 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 766760004831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760004832 putative active site [active] 766760004833 heme pocket [chemical binding]; other site 766760004834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760004835 dimer interface [polypeptide binding]; other site 766760004836 phosphorylation site [posttranslational modification] 766760004837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760004838 ATP binding site [chemical binding]; other site 766760004839 Mg2+ binding site [ion binding]; other site 766760004840 G-X-G motif; other site 766760004841 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 766760004842 TrkA-N domain; Region: TrkA_N; pfam02254 766760004843 TrkA-C domain; Region: TrkA_C; pfam02080 766760004844 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 766760004845 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 766760004846 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 766760004847 active site 766760004848 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 766760004849 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 766760004850 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 766760004851 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 766760004852 hypothetical protein; Provisional; Region: PRK13667 766760004853 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 766760004854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760004855 active site 766760004856 motif I; other site 766760004857 motif II; other site 766760004858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760004859 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 766760004860 active site 766760004861 catalytic residues [active] 766760004862 metal binding site [ion binding]; metal-binding site 766760004863 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 766760004864 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 766760004865 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 766760004866 TPP-binding site [chemical binding]; other site 766760004867 tetramer interface [polypeptide binding]; other site 766760004868 heterodimer interface [polypeptide binding]; other site 766760004869 phosphorylation loop region [posttranslational modification] 766760004870 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 766760004871 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 766760004872 alpha subunit interface [polypeptide binding]; other site 766760004873 TPP binding site [chemical binding]; other site 766760004874 heterodimer interface [polypeptide binding]; other site 766760004875 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 766760004876 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 766760004877 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 766760004878 E3 interaction surface; other site 766760004879 lipoyl attachment site [posttranslational modification]; other site 766760004880 e3 binding domain; Region: E3_binding; pfam02817 766760004881 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 766760004882 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 766760004883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 766760004884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760004885 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 766760004886 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 766760004887 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 766760004888 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 766760004889 homodimer interface [polypeptide binding]; other site 766760004890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760004891 catalytic residue [active] 766760004892 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 766760004893 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 766760004894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 766760004895 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 766760004896 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 766760004897 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 766760004898 active site 766760004899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760004900 Coenzyme A binding pocket [chemical binding]; other site 766760004901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760004902 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 766760004903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760004904 DNA binding residues [nucleotide binding] 766760004905 Putative zinc-finger; Region: zf-HC2; pfam13490 766760004906 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 766760004907 Transposase domain (DUF772); Region: DUF772; pfam05598 766760004908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760004909 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760004910 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 766760004911 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 766760004912 G1 box; other site 766760004913 putative GEF interaction site [polypeptide binding]; other site 766760004914 GTP/Mg2+ binding site [chemical binding]; other site 766760004915 Switch I region; other site 766760004916 G2 box; other site 766760004917 G3 box; other site 766760004918 Switch II region; other site 766760004919 G4 box; other site 766760004920 G5 box; other site 766760004921 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 766760004922 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 766760004923 YlaH-like protein; Region: YlaH; pfam14036 766760004924 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760004925 MarR family; Region: MarR; pfam01047 766760004926 hypothetical protein; Provisional; Region: PRK08244 766760004927 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 766760004928 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 766760004929 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 766760004930 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 766760004931 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 766760004932 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 766760004933 putative active site [active] 766760004934 PhoH-like protein; Region: PhoH; cl17668 766760004935 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 766760004936 glutaminase A; Region: Gln_ase; TIGR03814 766760004937 hypothetical protein; Provisional; Region: PRK13666 766760004938 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 766760004939 pyruvate carboxylase; Reviewed; Region: PRK12999 766760004940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760004941 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 766760004942 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 766760004943 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 766760004944 active site 766760004945 catalytic residues [active] 766760004946 metal binding site [ion binding]; metal-binding site 766760004947 homodimer binding site [polypeptide binding]; other site 766760004948 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 766760004949 carboxyltransferase (CT) interaction site; other site 766760004950 biotinylation site [posttranslational modification]; other site 766760004951 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 766760004952 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 766760004953 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 766760004954 UbiA prenyltransferase family; Region: UbiA; pfam01040 766760004955 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 766760004956 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 766760004957 Cytochrome c; Region: Cytochrom_C; pfam00034 766760004958 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 766760004959 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 766760004960 D-pathway; other site 766760004961 Putative ubiquinol binding site [chemical binding]; other site 766760004962 Low-spin heme (heme b) binding site [chemical binding]; other site 766760004963 Putative water exit pathway; other site 766760004964 Binuclear center (heme o3/CuB) [ion binding]; other site 766760004965 K-pathway; other site 766760004966 Putative proton exit pathway; other site 766760004967 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 766760004968 Subunit I/III interface [polypeptide binding]; other site 766760004969 Subunit III/IV interface [polypeptide binding]; other site 766760004970 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 766760004971 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 766760004972 YugN-like family; Region: YugN; pfam08868 766760004973 FOG: CBS domain [General function prediction only]; Region: COG0517 766760004974 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 766760004975 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 766760004976 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 766760004977 Putative coat protein; Region: YlbD_coat; pfam14071 766760004978 YlbE-like protein; Region: YlbE; pfam14003 766760004979 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 766760004980 hypothetical protein; Provisional; Region: PRK02886 766760004981 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 766760004982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760004983 S-adenosylmethionine binding site [chemical binding]; other site 766760004984 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 766760004985 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 766760004986 active site 766760004987 (T/H)XGH motif; other site 766760004988 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 766760004989 Nucleoside recognition; Region: Gate; pfam07670 766760004990 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 766760004991 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 766760004992 protein binding site [polypeptide binding]; other site 766760004993 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 766760004994 hypothetical protein; Provisional; Region: PRK13670 766760004995 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 766760004996 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 766760004997 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 766760004998 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 766760004999 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 766760005000 hypothetical protein; Provisional; Region: PRK13688 766760005001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760005002 Coenzyme A binding pocket [chemical binding]; other site 766760005003 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 766760005004 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 766760005005 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 766760005006 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 766760005007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 766760005008 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 766760005009 mraZ protein; Region: TIGR00242 766760005010 MraZ protein; Region: MraZ; pfam02381 766760005011 MraZ protein; Region: MraZ; pfam02381 766760005012 MraW methylase family; Region: Methyltransf_5; pfam01795 766760005013 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 766760005014 Cell division protein FtsL; Region: FtsL; cl11433 766760005015 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 766760005016 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 766760005017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760005018 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 766760005019 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 766760005020 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 766760005021 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 766760005022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760005023 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 766760005024 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 766760005025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 766760005026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 766760005027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 766760005028 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 766760005029 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 766760005030 Mg++ binding site [ion binding]; other site 766760005031 putative catalytic motif [active] 766760005032 putative substrate binding site [chemical binding]; other site 766760005033 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 766760005034 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 766760005035 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 766760005036 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 766760005037 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 766760005038 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 766760005039 active site 766760005040 homodimer interface [polypeptide binding]; other site 766760005041 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 766760005042 FAD binding domain; Region: FAD_binding_4; pfam01565 766760005043 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 766760005044 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 766760005045 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 766760005046 Cell division protein FtsQ; Region: FtsQ; pfam03799 766760005047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 766760005048 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 766760005049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 766760005050 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 766760005051 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 766760005052 cell division protein FtsA; Region: ftsA; TIGR01174 766760005053 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 766760005054 nucleotide binding site [chemical binding]; other site 766760005055 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 766760005056 Cell division protein FtsA; Region: FtsA; pfam14450 766760005057 cell division protein FtsZ; Validated; Region: PRK09330 766760005058 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 766760005059 nucleotide binding site [chemical binding]; other site 766760005060 SulA interaction site; other site 766760005061 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 766760005062 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 766760005063 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 766760005064 active site 766760005065 catalytic triad [active] 766760005066 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 766760005067 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 766760005068 active site 766760005069 catalytic triad [active] 766760005070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 766760005071 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 766760005072 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 766760005073 Cna protein B-type domain; Region: Cna_B_2; pfam13715 766760005074 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 766760005075 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 766760005076 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 766760005077 sporulation sigma factor SigE; Reviewed; Region: PRK08301 766760005078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760005079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760005080 DNA binding residues [nucleotide binding] 766760005081 sporulation sigma factor SigG; Reviewed; Region: PRK08215 766760005082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760005083 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 766760005084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760005085 DNA binding residues [nucleotide binding] 766760005086 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 766760005087 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 766760005088 Walker A/P-loop; other site 766760005089 ATP binding site [chemical binding]; other site 766760005090 Q-loop/lid; other site 766760005091 ABC transporter signature motif; other site 766760005092 Walker B; other site 766760005093 D-loop; other site 766760005094 H-loop/switch region; other site 766760005095 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 766760005096 Methyltransferase domain; Region: Methyltransf_11; pfam08241 766760005097 S-adenosylmethionine binding site [chemical binding]; other site 766760005098 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 766760005099 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 766760005100 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 766760005101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 766760005102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 766760005103 catalytic residue [active] 766760005104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 766760005105 YGGT family; Region: YGGT; pfam02325 766760005106 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 766760005107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760005108 RNA binding surface [nucleotide binding]; other site 766760005109 DivIVA protein; Region: DivIVA; pfam05103 766760005110 DivIVA domain; Region: DivI1A_domain; TIGR03544 766760005111 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 766760005112 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 766760005113 HIGH motif; other site 766760005114 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 766760005115 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 766760005116 active site 766760005117 KMSKS motif; other site 766760005118 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 766760005119 tRNA binding surface [nucleotide binding]; other site 766760005120 anticodon binding site; other site 766760005121 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 766760005122 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 766760005123 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 766760005124 lipoprotein signal peptidase; Provisional; Region: PRK14787 766760005125 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 766760005126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760005127 RNA binding surface [nucleotide binding]; other site 766760005128 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 766760005129 active site 766760005130 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 766760005131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760005132 active site 766760005133 uracil transporter; Provisional; Region: PRK10720 766760005134 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 766760005135 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 766760005136 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 766760005137 dihydroorotase; Validated; Region: pyrC; PRK09357 766760005138 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 766760005139 active site 766760005140 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 766760005141 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 766760005142 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 766760005143 catalytic site [active] 766760005144 subunit interface [polypeptide binding]; other site 766760005145 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 766760005146 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760005147 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 766760005148 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 766760005149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760005150 ATP-grasp domain; Region: ATP-grasp_4; cl17255 766760005151 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 766760005152 IMP binding site; other site 766760005153 dimer interface [polypeptide binding]; other site 766760005154 interdomain contacts; other site 766760005155 partial ornithine binding site; other site 766760005156 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 766760005157 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 766760005158 FAD binding pocket [chemical binding]; other site 766760005159 FAD binding motif [chemical binding]; other site 766760005160 phosphate binding motif [ion binding]; other site 766760005161 beta-alpha-beta structure motif; other site 766760005162 NAD binding pocket [chemical binding]; other site 766760005163 Iron coordination center [ion binding]; other site 766760005164 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 766760005165 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 766760005166 heterodimer interface [polypeptide binding]; other site 766760005167 active site 766760005168 FMN binding site [chemical binding]; other site 766760005169 homodimer interface [polypeptide binding]; other site 766760005170 substrate binding site [chemical binding]; other site 766760005171 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 766760005172 active site 766760005173 dimer interface [polypeptide binding]; other site 766760005174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760005175 active site 766760005176 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 766760005177 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 766760005178 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 766760005179 Active Sites [active] 766760005180 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 766760005181 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 766760005182 ATP-sulfurylase; Region: ATPS; cd00517 766760005183 active site 766760005184 HXXH motif; other site 766760005185 flexible loop; other site 766760005186 AAA domain; Region: AAA_33; pfam13671 766760005187 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 766760005188 ligand-binding site [chemical binding]; other site 766760005189 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 766760005190 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 766760005191 active site 766760005192 SAM binding site [chemical binding]; other site 766760005193 homodimer interface [polypeptide binding]; other site 766760005194 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 766760005195 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 766760005196 putative active site [active] 766760005197 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 766760005198 putative active site [active] 766760005199 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 766760005200 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 766760005201 Domain of unknown function (DUF814); Region: DUF814; pfam05670 766760005202 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 766760005203 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 766760005204 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 766760005205 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 766760005206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760005207 motif II; other site 766760005208 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 766760005209 hypothetical protein; Provisional; Region: PRK11820 766760005210 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 766760005211 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 766760005212 hypothetical protein; Provisional; Region: PRK04323 766760005213 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 766760005214 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 766760005215 catalytic site [active] 766760005216 G-X2-G-X-G-K; other site 766760005217 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 766760005218 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 766760005219 Flavoprotein; Region: Flavoprotein; pfam02441 766760005220 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 766760005221 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 766760005222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760005223 ATP binding site [chemical binding]; other site 766760005224 putative Mg++ binding site [ion binding]; other site 766760005225 helicase superfamily c-terminal domain; Region: HELICc; smart00490 766760005226 nucleotide binding region [chemical binding]; other site 766760005227 ATP-binding site [chemical binding]; other site 766760005228 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 766760005229 active site 766760005230 catalytic residues [active] 766760005231 metal binding site [ion binding]; metal-binding site 766760005232 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 766760005233 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 766760005234 putative active site [active] 766760005235 substrate binding site [chemical binding]; other site 766760005236 putative cosubstrate binding site; other site 766760005237 catalytic site [active] 766760005238 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 766760005239 substrate binding site [chemical binding]; other site 766760005240 16S rRNA methyltransferase B; Provisional; Region: PRK14902 766760005241 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 766760005242 putative RNA binding site [nucleotide binding]; other site 766760005243 FtsJ-like methyltransferase; Region: FtsJ; cl17430 766760005244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760005245 S-adenosylmethionine binding site [chemical binding]; other site 766760005246 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 766760005247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760005248 FeS/SAM binding site; other site 766760005249 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 766760005250 Protein phosphatase 2C; Region: PP2C; pfam00481 766760005251 active site 766760005252 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 766760005253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 766760005254 active site 766760005255 ATP binding site [chemical binding]; other site 766760005256 substrate binding site [chemical binding]; other site 766760005257 activation loop (A-loop); other site 766760005258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 766760005259 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 766760005260 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 766760005261 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 766760005262 GTPase RsgA; Reviewed; Region: PRK00098 766760005263 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 766760005264 RNA binding site [nucleotide binding]; other site 766760005265 homodimer interface [polypeptide binding]; other site 766760005266 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 766760005267 GTPase/Zn-binding domain interface [polypeptide binding]; other site 766760005268 GTP/Mg2+ binding site [chemical binding]; other site 766760005269 G4 box; other site 766760005270 G5 box; other site 766760005271 G1 box; other site 766760005272 Switch I region; other site 766760005273 G2 box; other site 766760005274 G3 box; other site 766760005275 Switch II region; other site 766760005276 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 766760005277 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 766760005278 substrate binding site [chemical binding]; other site 766760005279 hexamer interface [polypeptide binding]; other site 766760005280 metal binding site [ion binding]; metal-binding site 766760005281 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 766760005282 Thiamine pyrophosphokinase; Region: TPK; cd07995 766760005283 active site 766760005284 dimerization interface [polypeptide binding]; other site 766760005285 thiamine binding site [chemical binding]; other site 766760005286 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 766760005287 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 766760005288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 766760005289 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 766760005290 DAK2 domain; Region: Dak2; pfam02734 766760005291 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 766760005292 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 766760005293 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 766760005294 putative L-serine binding site [chemical binding]; other site 766760005295 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 766760005296 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 766760005297 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 766760005298 Y-family of DNA polymerases; Region: PolY; cl12025 766760005299 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 766760005300 generic binding surface II; other site 766760005301 ssDNA binding site; other site 766760005302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760005303 ATP binding site [chemical binding]; other site 766760005304 putative Mg++ binding site [ion binding]; other site 766760005305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760005306 nucleotide binding region [chemical binding]; other site 766760005307 ATP-binding site [chemical binding]; other site 766760005308 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 766760005309 HTH domain; Region: HTH_11; cl17392 766760005310 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 766760005311 putative phosphate acyltransferase; Provisional; Region: PRK05331 766760005312 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 766760005313 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 766760005314 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 766760005315 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 766760005316 NAD(P) binding site [chemical binding]; other site 766760005317 homotetramer interface [polypeptide binding]; other site 766760005318 homodimer interface [polypeptide binding]; other site 766760005319 active site 766760005320 acyl carrier protein; Provisional; Region: acpP; PRK00982 766760005321 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 766760005322 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 766760005323 dimerization interface [polypeptide binding]; other site 766760005324 active site 766760005325 metal binding site [ion binding]; metal-binding site 766760005326 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 766760005327 dsRNA binding site [nucleotide binding]; other site 766760005328 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 766760005329 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 766760005330 Walker A/P-loop; other site 766760005331 ATP binding site [chemical binding]; other site 766760005332 Q-loop/lid; other site 766760005333 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 766760005334 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 766760005335 Q-loop/lid; other site 766760005336 ABC transporter signature motif; other site 766760005337 Walker B; other site 766760005338 D-loop; other site 766760005339 H-loop/switch region; other site 766760005340 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 766760005341 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 766760005342 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 766760005343 P loop; other site 766760005344 GTP binding site [chemical binding]; other site 766760005345 putative DNA-binding protein; Validated; Region: PRK00118 766760005346 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 766760005347 signal recognition particle protein; Provisional; Region: PRK10867 766760005348 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 766760005349 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 766760005350 P loop; other site 766760005351 GTP binding site [chemical binding]; other site 766760005352 Signal peptide binding domain; Region: SRP_SPB; pfam02978 766760005353 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 766760005354 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 766760005355 KH domain; Region: KH_4; pfam13083 766760005356 G-X-X-G motif; other site 766760005357 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 766760005358 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 766760005359 RimM N-terminal domain; Region: RimM; pfam01782 766760005360 PRC-barrel domain; Region: PRC; pfam05239 766760005361 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 766760005362 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 766760005363 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 766760005364 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 766760005365 GTP/Mg2+ binding site [chemical binding]; other site 766760005366 G4 box; other site 766760005367 G5 box; other site 766760005368 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 766760005369 G1 box; other site 766760005370 G1 box; other site 766760005371 GTP/Mg2+ binding site [chemical binding]; other site 766760005372 Switch I region; other site 766760005373 G2 box; other site 766760005374 G2 box; other site 766760005375 G3 box; other site 766760005376 G3 box; other site 766760005377 Switch II region; other site 766760005378 Switch II region; other site 766760005379 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 766760005380 RNA/DNA hybrid binding site [nucleotide binding]; other site 766760005381 active site 766760005382 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 766760005383 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 766760005384 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 766760005385 CoA-ligase; Region: Ligase_CoA; pfam00549 766760005386 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 766760005387 CoA binding domain; Region: CoA_binding; pfam02629 766760005388 CoA-ligase; Region: Ligase_CoA; pfam00549 766760005389 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 766760005390 DNA protecting protein DprA; Region: dprA; TIGR00732 766760005391 DNA topoisomerase I; Validated; Region: PRK05582 766760005392 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 766760005393 active site 766760005394 interdomain interaction site; other site 766760005395 putative metal-binding site [ion binding]; other site 766760005396 nucleotide binding site [chemical binding]; other site 766760005397 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 766760005398 domain I; other site 766760005399 DNA binding groove [nucleotide binding] 766760005400 phosphate binding site [ion binding]; other site 766760005401 domain II; other site 766760005402 domain III; other site 766760005403 nucleotide binding site [chemical binding]; other site 766760005404 catalytic site [active] 766760005405 domain IV; other site 766760005406 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 766760005407 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 766760005408 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 766760005409 Glucose inhibited division protein A; Region: GIDA; pfam01134 766760005410 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 766760005411 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 766760005412 active site 766760005413 Int/Topo IB signature motif; other site 766760005414 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 766760005415 active site 766760005416 HslU subunit interaction site [polypeptide binding]; other site 766760005417 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 766760005418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760005419 Walker A motif; other site 766760005420 ATP binding site [chemical binding]; other site 766760005421 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 766760005422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 766760005423 transcriptional repressor CodY; Validated; Region: PRK04158 766760005424 CodY GAF-like domain; Region: CodY; pfam06018 766760005425 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 766760005426 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 766760005427 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 766760005428 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 766760005429 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 766760005430 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 766760005431 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 766760005432 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 766760005433 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 766760005434 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 766760005435 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 766760005436 MgtE intracellular N domain; Region: MgtE_N; cl15244 766760005437 FliG C-terminal domain; Region: FliG_C; pfam01706 766760005438 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 766760005439 Flagellar assembly protein FliH; Region: FliH; pfam02108 766760005440 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 766760005441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 766760005442 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 766760005443 Walker A motif/ATP binding site; other site 766760005444 Walker B motif; other site 766760005445 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 766760005446 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 766760005447 Uncharacterized conserved protein [Function unknown]; Region: COG3334 766760005448 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 766760005449 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 766760005450 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 766760005451 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 766760005452 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 766760005453 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 766760005454 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 766760005455 Flagellar protein (FlbD); Region: FlbD; pfam06289 766760005456 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 766760005457 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 766760005458 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 766760005459 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 766760005460 flagellar motor switch protein; Validated; Region: PRK08119 766760005461 CheC-like family; Region: CheC; pfam04509 766760005462 CheC-like family; Region: CheC; pfam04509 766760005463 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 766760005464 Response regulator receiver domain; Region: Response_reg; pfam00072 766760005465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760005466 active site 766760005467 phosphorylation site [posttranslational modification] 766760005468 intermolecular recognition site; other site 766760005469 dimerization interface [polypeptide binding]; other site 766760005470 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 766760005471 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 766760005472 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 766760005473 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 766760005474 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 766760005475 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 766760005476 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 766760005477 FHIPEP family; Region: FHIPEP; pfam00771 766760005478 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 766760005479 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 766760005480 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 766760005481 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 766760005482 P-loop; other site 766760005483 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 766760005484 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 766760005485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760005486 active site 766760005487 phosphorylation site [posttranslational modification] 766760005488 intermolecular recognition site; other site 766760005489 dimerization interface [polypeptide binding]; other site 766760005490 CheB methylesterase; Region: CheB_methylest; pfam01339 766760005491 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 766760005492 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 766760005493 putative binding surface; other site 766760005494 active site 766760005495 P2 response regulator binding domain; Region: P2; pfam07194 766760005496 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 766760005497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760005498 ATP binding site [chemical binding]; other site 766760005499 Mg2+ binding site [ion binding]; other site 766760005500 G-X-G motif; other site 766760005501 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 766760005502 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 766760005503 putative CheA interaction surface; other site 766760005504 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 766760005505 CheC-like family; Region: CheC; pfam04509 766760005506 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 766760005507 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 766760005508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760005509 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 766760005510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760005511 DNA binding residues [nucleotide binding] 766760005512 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 766760005513 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 766760005514 rRNA interaction site [nucleotide binding]; other site 766760005515 S8 interaction site; other site 766760005516 putative laminin-1 binding site; other site 766760005517 elongation factor Ts; Provisional; Region: tsf; PRK09377 766760005518 UBA/TS-N domain; Region: UBA; pfam00627 766760005519 Elongation factor TS; Region: EF_TS; pfam00889 766760005520 Elongation factor TS; Region: EF_TS; pfam00889 766760005521 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 766760005522 putative nucleotide binding site [chemical binding]; other site 766760005523 uridine monophosphate binding site [chemical binding]; other site 766760005524 homohexameric interface [polypeptide binding]; other site 766760005525 ribosome recycling factor; Reviewed; Region: frr; PRK00083 766760005526 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 766760005527 hinge region; other site 766760005528 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 766760005529 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 766760005530 catalytic residue [active] 766760005531 putative FPP diphosphate binding site; other site 766760005532 putative FPP binding hydrophobic cleft; other site 766760005533 dimer interface [polypeptide binding]; other site 766760005534 putative IPP diphosphate binding site; other site 766760005535 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 766760005536 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 766760005537 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 766760005538 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 766760005539 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 766760005540 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 766760005541 RIP metalloprotease RseP; Region: TIGR00054 766760005542 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 766760005543 active site 766760005544 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 766760005545 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 766760005546 protein binding site [polypeptide binding]; other site 766760005547 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 766760005548 putative substrate binding region [chemical binding]; other site 766760005549 prolyl-tRNA synthetase; Provisional; Region: PRK09194 766760005550 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 766760005551 dimer interface [polypeptide binding]; other site 766760005552 motif 1; other site 766760005553 active site 766760005554 motif 2; other site 766760005555 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 766760005556 putative deacylase active site [active] 766760005557 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 766760005558 active site 766760005559 motif 3; other site 766760005560 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 766760005561 anticodon binding site; other site 766760005562 DNA polymerase III PolC; Validated; Region: polC; PRK00448 766760005563 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 766760005564 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 766760005565 generic binding surface II; other site 766760005566 generic binding surface I; other site 766760005567 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 766760005568 active site 766760005569 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 766760005570 active site 766760005571 catalytic site [active] 766760005572 substrate binding site [chemical binding]; other site 766760005573 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 766760005574 endoglucanase; Region: PLN02420 766760005575 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 766760005576 Cellulose binding domain; Region: CBM_3; pfam00942 766760005577 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 766760005578 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 766760005579 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 766760005580 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 766760005581 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 766760005582 ribosome maturation protein RimP; Reviewed; Region: PRK00092 766760005583 Sm and related proteins; Region: Sm_like; cl00259 766760005584 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 766760005585 putative oligomer interface [polypeptide binding]; other site 766760005586 putative RNA binding site [nucleotide binding]; other site 766760005587 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 766760005588 NusA N-terminal domain; Region: NusA_N; pfam08529 766760005589 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 766760005590 RNA binding site [nucleotide binding]; other site 766760005591 homodimer interface [polypeptide binding]; other site 766760005592 NusA-like KH domain; Region: KH_5; pfam13184 766760005593 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 766760005594 G-X-X-G motif; other site 766760005595 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 766760005596 putative RNA binding cleft [nucleotide binding]; other site 766760005597 hypothetical protein; Provisional; Region: PRK07714 766760005598 translation initiation factor IF-2; Validated; Region: infB; PRK05306 766760005599 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 766760005600 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 766760005601 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 766760005602 G1 box; other site 766760005603 putative GEF interaction site [polypeptide binding]; other site 766760005604 GTP/Mg2+ binding site [chemical binding]; other site 766760005605 Switch I region; other site 766760005606 G2 box; other site 766760005607 G3 box; other site 766760005608 Switch II region; other site 766760005609 G4 box; other site 766760005610 G5 box; other site 766760005611 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 766760005612 Translation-initiation factor 2; Region: IF-2; pfam11987 766760005613 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 766760005614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 766760005615 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 766760005616 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 766760005617 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 766760005618 RNA binding site [nucleotide binding]; other site 766760005619 active site 766760005620 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 766760005621 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 766760005622 active site 766760005623 Riboflavin kinase; Region: Flavokinase; smart00904 766760005624 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 766760005625 16S/18S rRNA binding site [nucleotide binding]; other site 766760005626 S13e-L30e interaction site [polypeptide binding]; other site 766760005627 25S rRNA binding site [nucleotide binding]; other site 766760005628 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 766760005629 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 766760005630 RNase E interface [polypeptide binding]; other site 766760005631 trimer interface [polypeptide binding]; other site 766760005632 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 766760005633 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 766760005634 RNase E interface [polypeptide binding]; other site 766760005635 trimer interface [polypeptide binding]; other site 766760005636 active site 766760005637 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 766760005638 putative nucleic acid binding region [nucleotide binding]; other site 766760005639 G-X-X-G motif; other site 766760005640 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 766760005641 RNA binding site [nucleotide binding]; other site 766760005642 domain interface; other site 766760005643 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 766760005644 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 766760005645 NodB motif; other site 766760005646 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 766760005647 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 766760005648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 766760005649 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 766760005650 dipicolinic acid synthetase, A subunit; Region: spore_dpaA; TIGR02853 766760005651 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 766760005652 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 766760005653 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 766760005654 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 766760005655 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 766760005656 aspartate kinase I; Reviewed; Region: PRK08210 766760005657 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 766760005658 nucleotide binding site [chemical binding]; other site 766760005659 substrate binding site [chemical binding]; other site 766760005660 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 766760005661 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 766760005662 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 766760005663 dihydrodipicolinate synthase; Region: dapA; TIGR00674 766760005664 dimer interface [polypeptide binding]; other site 766760005665 active site 766760005666 catalytic residue [active] 766760005667 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 766760005668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760005669 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 766760005670 Clp protease; Region: CLP_protease; pfam00574 766760005671 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 766760005672 active site 766760005673 YlzJ-like protein; Region: YlzJ; pfam14035 766760005674 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 766760005675 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 766760005676 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 766760005677 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 766760005678 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 766760005679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760005680 DNA-binding site [nucleotide binding]; DNA binding site 766760005681 UTRA domain; Region: UTRA; pfam07702 766760005682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760005683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760005684 putative substrate translocation pore; other site 766760005685 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 766760005686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 766760005687 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 766760005688 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 766760005689 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 766760005690 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 766760005691 classical (c) SDRs; Region: SDR_c; cd05233 766760005692 NAD(P) binding site [chemical binding]; other site 766760005693 active site 766760005694 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 766760005695 ACT domain; Region: ACT; pfam01842 766760005696 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 766760005697 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 766760005698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760005699 non-specific DNA binding site [nucleotide binding]; other site 766760005700 salt bridge; other site 766760005701 sequence-specific DNA binding site [nucleotide binding]; other site 766760005702 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 766760005703 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 766760005704 competence damage-inducible protein A; Provisional; Region: PRK00549 766760005705 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 766760005706 putative MPT binding site; other site 766760005707 Competence-damaged protein; Region: CinA; pfam02464 766760005708 recombinase A; Provisional; Region: recA; PRK09354 766760005709 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 766760005710 hexamer interface [polypeptide binding]; other site 766760005711 Walker A motif; other site 766760005712 ATP binding site [chemical binding]; other site 766760005713 Walker B motif; other site 766760005714 phosphodiesterase; Provisional; Region: PRK12704 766760005715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760005716 Zn2+ binding site [ion binding]; other site 766760005717 Mg2+ binding site [ion binding]; other site 766760005718 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 766760005719 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 766760005720 putative active site [active] 766760005721 metal binding site [ion binding]; metal-binding site 766760005722 homodimer binding site [polypeptide binding]; other site 766760005723 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 766760005724 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 766760005725 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 766760005726 active site 766760005727 dimer interface [polypeptide binding]; other site 766760005728 Threonine dehydrogenase; Region: TDH; cd05281 766760005729 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 766760005730 structural Zn binding site [ion binding]; other site 766760005731 catalytic Zn binding site [ion binding]; other site 766760005732 tetramer interface [polypeptide binding]; other site 766760005733 NADP binding site [chemical binding]; other site 766760005734 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 766760005735 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 766760005736 substrate-cofactor binding pocket; other site 766760005737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760005738 catalytic residue [active] 766760005739 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 766760005740 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 766760005741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760005742 FeS/SAM binding site; other site 766760005743 TRAM domain; Region: TRAM; cl01282 766760005744 Predicted membrane protein [Function unknown]; Region: COG4550 766760005745 Outer spore coat protein E (CotE); Region: CotE; pfam10628 766760005746 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 766760005747 MutS domain I; Region: MutS_I; pfam01624 766760005748 MutS domain II; Region: MutS_II; pfam05188 766760005749 MutS domain III; Region: MutS_III; pfam05192 766760005750 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 766760005751 Walker A/P-loop; other site 766760005752 ATP binding site [chemical binding]; other site 766760005753 Q-loop/lid; other site 766760005754 ABC transporter signature motif; other site 766760005755 Walker B; other site 766760005756 D-loop; other site 766760005757 H-loop/switch region; other site 766760005758 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 766760005759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760005760 ATP binding site [chemical binding]; other site 766760005761 Mg2+ binding site [ion binding]; other site 766760005762 G-X-G motif; other site 766760005763 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 766760005764 ATP binding site [chemical binding]; other site 766760005765 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 766760005766 Uncharacterized conserved protein [Function unknown]; Region: COG1359 766760005767 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 766760005768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760005769 binding surface 766760005770 TPR motif; other site 766760005771 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760005772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760005773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760005774 TPR motif; other site 766760005775 binding surface 766760005776 TPR repeat; Region: TPR_11; pfam13414 766760005777 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760005778 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 766760005779 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 766760005780 P-loop, Walker A motif; other site 766760005781 Base recognition motif; other site 766760005782 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 766760005783 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 766760005784 dimer interface [polypeptide binding]; other site 766760005785 [2Fe-2S] cluster binding site [ion binding]; other site 766760005786 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 766760005787 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 766760005788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760005789 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 766760005790 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 766760005791 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 766760005792 TrkA-C domain; Region: TrkA_C; pfam02080 766760005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760005794 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 766760005795 putative substrate translocation pore; other site 766760005796 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 766760005797 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 766760005798 Uncharacterized conserved protein [Function unknown]; Region: COG0398 766760005799 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 766760005800 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 766760005801 Beta-lactamase; Region: Beta-lactamase; pfam00144 766760005802 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 766760005803 glycosyltransferase, MGT family; Region: MGT; TIGR01426 766760005804 active site 766760005805 TDP-binding site; other site 766760005806 acceptor substrate-binding pocket; other site 766760005807 homodimer interface [polypeptide binding]; other site 766760005808 amino acid transporter; Region: 2A0306; TIGR00909 766760005809 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 766760005810 Coat F domain; Region: Coat_F; cl17715 766760005811 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 766760005812 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760005813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760005814 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 766760005815 active site 766760005816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760005817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760005818 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 766760005819 SnoaL-like domain; Region: SnoaL_3; pfam13474 766760005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760005821 NADH(P)-binding; Region: NAD_binding_10; pfam13460 766760005822 NAD(P) binding site [chemical binding]; other site 766760005823 active site 766760005824 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 766760005825 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 766760005826 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 766760005827 YmaF family; Region: YmaF; pfam12788 766760005828 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 766760005829 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 766760005830 bacterial Hfq-like; Region: Hfq; cd01716 766760005831 hexamer interface [polypeptide binding]; other site 766760005832 Sm1 motif; other site 766760005833 RNA binding site [nucleotide binding]; other site 766760005834 Sm2 motif; other site 766760005835 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 766760005836 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 766760005837 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 766760005838 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 766760005839 Class I ribonucleotide reductase; Region: RNR_I; cd01679 766760005840 active site 766760005841 dimer interface [polypeptide binding]; other site 766760005842 catalytic residues [active] 766760005843 effector binding site; other site 766760005844 R2 peptide binding site; other site 766760005845 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 766760005846 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 766760005847 dimer interface [polypeptide binding]; other site 766760005848 putative radical transfer pathway; other site 766760005849 diiron center [ion binding]; other site 766760005850 tyrosyl radical; other site 766760005851 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 766760005852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760005853 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 766760005854 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 766760005855 trimerization site [polypeptide binding]; other site 766760005856 active site 766760005857 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760005858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760005859 DNA-binding site [nucleotide binding]; DNA binding site 766760005860 FCD domain; Region: FCD; pfam07729 766760005861 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 766760005862 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 766760005863 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 766760005864 active site 766760005865 metal binding site [ion binding]; metal-binding site 766760005866 Sporulation related domain; Region: SPOR; pfam05036 766760005867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 766760005868 Protein of unknown function, DUF606; Region: DUF606; pfam04657 766760005869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760005870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760005871 OsmC-like protein; Region: OsmC; pfam02566 766760005872 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 766760005873 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 766760005874 Na binding site [ion binding]; other site 766760005875 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 766760005876 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 766760005877 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 766760005878 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 766760005879 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 766760005880 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 766760005881 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 766760005882 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760005883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760005884 TPR motif; other site 766760005885 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760005886 binding surface 766760005887 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 766760005888 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 766760005889 RNAase interaction site [polypeptide binding]; other site 766760005890 Urea transporter; Region: UT; cl01829 766760005891 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 766760005892 alpha-gamma subunit interface [polypeptide binding]; other site 766760005893 beta-gamma subunit interface [polypeptide binding]; other site 766760005894 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 766760005895 gamma-beta subunit interface [polypeptide binding]; other site 766760005896 alpha-beta subunit interface [polypeptide binding]; other site 766760005897 urease subunit alpha; Reviewed; Region: ureC; PRK13207 766760005898 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 766760005899 subunit interactions [polypeptide binding]; other site 766760005900 active site 766760005901 flap region; other site 766760005902 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 766760005903 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 766760005904 dimer interface [polypeptide binding]; other site 766760005905 catalytic residues [active] 766760005906 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 766760005907 UreF; Region: UreF; pfam01730 766760005908 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 766760005909 UreD urease accessory protein; Region: UreD; cl00530 766760005910 High-affinity nickel-transport protein; Region: NicO; cl00964 766760005911 Predicted transcriptional regulators [Transcription]; Region: COG1695 766760005912 Transcriptional regulator PadR-like family; Region: PadR; cl17335 766760005913 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 766760005914 stage V sporulation protein K; Region: spore_V_K; TIGR02881 766760005915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760005916 Walker A motif; other site 766760005917 ATP binding site [chemical binding]; other site 766760005918 Walker B motif; other site 766760005919 arginine finger; other site 766760005920 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 766760005921 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 766760005922 HflX GTPase family; Region: HflX; cd01878 766760005923 G1 box; other site 766760005924 GTP/Mg2+ binding site [chemical binding]; other site 766760005925 Switch I region; other site 766760005926 G2 box; other site 766760005927 G3 box; other site 766760005928 Switch II region; other site 766760005929 G4 box; other site 766760005930 G5 box; other site 766760005931 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 766760005932 Aluminium resistance protein; Region: Alum_res; pfam06838 766760005933 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 766760005934 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 766760005935 DNA binding residues [nucleotide binding] 766760005936 glutamine synthetase, type I; Region: GlnA; TIGR00653 766760005937 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 766760005938 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 766760005939 glutamine synthetase, type I; Region: GlnA; TIGR00653 766760005940 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 766760005941 dimanganese center [ion binding]; other site 766760005942 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 766760005943 TrkA-C domain; Region: TrkA_C; pfam02080 766760005944 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 766760005945 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 766760005946 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760005947 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 766760005948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760005949 S-adenosylmethionine binding site [chemical binding]; other site 766760005950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760005951 Coenzyme A binding pocket [chemical binding]; other site 766760005952 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 766760005953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760005954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760005955 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 766760005956 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 766760005957 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 766760005958 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 766760005959 Coenzyme A binding pocket [chemical binding]; other site 766760005960 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 766760005961 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 766760005962 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 766760005963 catalytic residues [active] 766760005964 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 766760005965 dimanganese center [ion binding]; other site 766760005966 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 766760005967 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 766760005968 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760005969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760005970 Coenzyme A binding pocket [chemical binding]; other site 766760005971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760005972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760005973 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 766760005974 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760005975 MarR family; Region: MarR; pfam01047 766760005976 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 766760005977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760005978 Zn binding site [ion binding]; other site 766760005979 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 766760005980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760005981 Zn binding site [ion binding]; other site 766760005982 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 766760005983 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 766760005984 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760005985 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 766760005986 thymidylate synthase; Reviewed; Region: thyA; PRK01827 766760005987 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 766760005988 dimerization interface [polypeptide binding]; other site 766760005989 active site 766760005990 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 766760005991 LexA repressor; Validated; Region: PRK00215 766760005992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760005993 putative DNA binding site [nucleotide binding]; other site 766760005994 putative Zn2+ binding site [ion binding]; other site 766760005995 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 766760005996 Catalytic site [active] 766760005997 cell division suppressor protein YneA; Provisional; Region: PRK14125 766760005998 LysM domain; Region: LysM; pfam01476 766760005999 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 766760006000 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 766760006001 catalytic residues [active] 766760006002 catalytic nucleophile [active] 766760006003 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 766760006004 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 766760006005 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 766760006006 TPP-binding site [chemical binding]; other site 766760006007 dimer interface [polypeptide binding]; other site 766760006008 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 766760006009 PYR/PP interface [polypeptide binding]; other site 766760006010 dimer interface [polypeptide binding]; other site 766760006011 TPP binding site [chemical binding]; other site 766760006012 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 766760006013 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 766760006014 hypothetical protein; Provisional; Region: PRK01844 766760006015 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 766760006016 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 766760006017 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 766760006018 Response regulator receiver domain; Region: Response_reg; pfam00072 766760006019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760006020 active site 766760006021 phosphorylation site [posttranslational modification] 766760006022 intermolecular recognition site; other site 766760006023 dimerization interface [polypeptide binding]; other site 766760006024 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 766760006025 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 766760006026 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 766760006027 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 766760006028 putative dimer interface [polypeptide binding]; other site 766760006029 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 766760006030 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 766760006031 aconitate hydratase; Validated; Region: PRK09277 766760006032 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 766760006033 substrate binding site [chemical binding]; other site 766760006034 ligand binding site [chemical binding]; other site 766760006035 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 766760006036 substrate binding site [chemical binding]; other site 766760006037 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 766760006038 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 766760006039 catalytic residues [active] 766760006040 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 766760006041 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 766760006042 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 766760006043 active site 766760006044 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 766760006045 Uncharacterized conserved protein [Function unknown]; Region: COG1434 766760006046 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 766760006047 putative active site [active] 766760006048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 766760006049 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 766760006050 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 766760006051 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 766760006052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760006053 ATP binding site [chemical binding]; other site 766760006054 Mg2+ binding site [ion binding]; other site 766760006055 G-X-G motif; other site 766760006056 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 766760006057 anchoring element; other site 766760006058 dimer interface [polypeptide binding]; other site 766760006059 ATP binding site [chemical binding]; other site 766760006060 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 766760006061 active site 766760006062 putative metal-binding site [ion binding]; other site 766760006063 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 766760006064 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 766760006065 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 766760006066 CAP-like domain; other site 766760006067 active site 766760006068 primary dimer interface [polypeptide binding]; other site 766760006069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760006070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760006071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 766760006072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760006073 DNA-binding site [nucleotide binding]; DNA binding site 766760006074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760006075 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 766760006076 putative dimerization interface [polypeptide binding]; other site 766760006077 putative ligand binding site [chemical binding]; other site 766760006078 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 766760006079 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 766760006080 putative N- and C-terminal domain interface [polypeptide binding]; other site 766760006081 putative active site [active] 766760006082 MgATP binding site [chemical binding]; other site 766760006083 catalytic site [active] 766760006084 metal binding site [ion binding]; metal-binding site 766760006085 putative carbohydrate binding site [chemical binding]; other site 766760006086 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 766760006087 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 766760006088 intersubunit interface [polypeptide binding]; other site 766760006089 active site 766760006090 Zn2+ binding site [ion binding]; other site 766760006091 L-arabinose isomerase; Provisional; Region: PRK02929 766760006092 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 766760006093 hexamer (dimer of trimers) interface [polypeptide binding]; other site 766760006094 trimer interface [polypeptide binding]; other site 766760006095 substrate binding site [chemical binding]; other site 766760006096 Mn binding site [ion binding]; other site 766760006097 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 766760006098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006099 putative substrate translocation pore; other site 766760006100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006101 acetoin reductase; Validated; Region: PRK08643 766760006102 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 766760006103 NAD binding site [chemical binding]; other site 766760006104 homotetramer interface [polypeptide binding]; other site 766760006105 homodimer interface [polypeptide binding]; other site 766760006106 active site 766760006107 substrate binding site [chemical binding]; other site 766760006108 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 766760006109 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 766760006110 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 766760006111 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 766760006112 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 766760006113 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 766760006114 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 766760006115 [4Fe-4S] binding site [ion binding]; other site 766760006116 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760006117 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760006118 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760006119 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 766760006120 molybdopterin cofactor binding site; other site 766760006121 Uncharacterized conserved protein [Function unknown]; Region: COG2461 766760006122 Family of unknown function (DUF438); Region: DUF438; pfam04282 766760006123 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 766760006124 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 766760006125 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 766760006126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760006127 FeS/SAM binding site; other site 766760006128 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 766760006129 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 766760006130 YwiC-like protein; Region: YwiC; pfam14256 766760006131 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 766760006132 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 766760006133 ligand binding site [chemical binding]; other site 766760006134 flexible hinge region; other site 766760006135 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 766760006136 putative switch regulator; other site 766760006137 non-specific DNA interactions [nucleotide binding]; other site 766760006138 DNA binding site [nucleotide binding] 766760006139 sequence specific DNA binding site [nucleotide binding]; other site 766760006140 putative cAMP binding site [chemical binding]; other site 766760006141 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 766760006142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006143 putative substrate translocation pore; other site 766760006144 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 766760006145 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 766760006146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 766760006147 ligand binding site [chemical binding]; other site 766760006148 flexible hinge region; other site 766760006149 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 766760006150 putative switch regulator; other site 766760006151 non-specific DNA interactions [nucleotide binding]; other site 766760006152 DNA binding site [nucleotide binding] 766760006153 sequence specific DNA binding site [nucleotide binding]; other site 766760006154 putative cAMP binding site [chemical binding]; other site 766760006155 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 766760006156 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 766760006157 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 766760006158 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 766760006159 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 766760006160 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 766760006161 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 766760006162 Cellulose binding domain; Region: CBM_3; pfam00942 766760006163 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 766760006164 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 766760006165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760006166 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 766760006167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760006168 S-adenosylmethionine binding site [chemical binding]; other site 766760006169 Rrf2 family protein; Region: rrf2_super; TIGR00738 766760006170 Transcriptional regulator; Region: Rrf2; pfam02082 766760006171 Right handed beta helix region; Region: Beta_helix; pfam13229 766760006172 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 766760006173 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 766760006174 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 766760006175 putative substrate binding site [chemical binding]; other site 766760006176 catalytic Zn binding site [ion binding]; other site 766760006177 structural Zn binding site [ion binding]; other site 766760006178 dimer interface [polypeptide binding]; other site 766760006179 putative NAD(P) binding site [chemical binding]; other site 766760006180 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 766760006181 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 766760006182 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 766760006183 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 766760006184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760006185 substrate binding site [chemical binding]; other site 766760006186 oxyanion hole (OAH) forming residues; other site 766760006187 trimer interface [polypeptide binding]; other site 766760006188 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 766760006189 enoyl-CoA hydratase; Provisional; Region: PRK07658 766760006190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760006191 substrate binding site [chemical binding]; other site 766760006192 oxyanion hole (OAH) forming residues; other site 766760006193 trimer interface [polypeptide binding]; other site 766760006194 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 766760006195 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 766760006196 tetrameric interface [polypeptide binding]; other site 766760006197 NAD binding site [chemical binding]; other site 766760006198 catalytic residues [active] 766760006199 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 766760006200 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 766760006201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 766760006202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 766760006203 active site 766760006204 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 766760006205 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 766760006206 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 766760006207 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 766760006208 active site 766760006209 P-loop; other site 766760006210 phosphorylation site [posttranslational modification] 766760006211 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 766760006212 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760006213 active site 766760006214 phosphorylation site [posttranslational modification] 766760006215 YfzA-like protein; Region: YfzA; pfam14118 766760006216 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 766760006217 HTH domain; Region: HTH_11; pfam08279 766760006218 Mga helix-turn-helix domain; Region: Mga; pfam05043 766760006219 PRD domain; Region: PRD; pfam00874 766760006220 PRD domain; Region: PRD; pfam00874 766760006221 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 766760006222 active site 766760006223 P-loop; other site 766760006224 phosphorylation site [posttranslational modification] 766760006225 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760006226 active site 766760006227 phosphorylation site [posttranslational modification] 766760006228 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 766760006229 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760006230 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760006231 Walker A/P-loop; other site 766760006232 ATP binding site [chemical binding]; other site 766760006233 Q-loop/lid; other site 766760006234 ABC transporter signature motif; other site 766760006235 Walker B; other site 766760006236 D-loop; other site 766760006237 H-loop/switch region; other site 766760006238 Predicted transcriptional regulators [Transcription]; Region: COG1725 766760006239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760006240 DNA-binding site [nucleotide binding]; DNA binding site 766760006241 D-mannonate oxidoreductase; Provisional; Region: PRK08277 766760006242 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 766760006243 putative NAD(P) binding site [chemical binding]; other site 766760006244 active site 766760006245 mannonate dehydratase; Provisional; Region: PRK03906 766760006246 mannonate dehydratase; Region: uxuA; TIGR00695 766760006247 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 766760006248 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 766760006249 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 766760006250 putative active site [active] 766760006251 putative catalytic site [active] 766760006252 DctM-like transporters; Region: DctM; pfam06808 766760006253 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 766760006254 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 766760006255 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 766760006256 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 766760006257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760006258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760006259 DNA binding site [nucleotide binding] 766760006260 domain linker motif; other site 766760006261 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 766760006262 putative dimerization interface [polypeptide binding]; other site 766760006263 putative ligand binding site [chemical binding]; other site 766760006264 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 766760006265 Low molecular weight phosphatase family; Region: LMWPc; cd00115 766760006266 active site 766760006267 arsenical pump membrane protein; Provisional; Region: PRK15445 766760006268 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 766760006269 transmembrane helices; other site 766760006270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760006271 dimerization interface [polypeptide binding]; other site 766760006272 putative DNA binding site [nucleotide binding]; other site 766760006273 putative Zn2+ binding site [ion binding]; other site 766760006274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 766760006275 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 766760006276 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 766760006277 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 766760006278 putative catalytic site [active] 766760006279 putative metal binding site [ion binding]; other site 766760006280 putative phosphate binding site [ion binding]; other site 766760006281 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 766760006282 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 766760006283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 766760006284 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 766760006285 DHH family; Region: DHH; pfam01368 766760006286 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 766760006287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760006288 FeS/SAM binding site; other site 766760006289 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 766760006290 Pyruvate formate lyase 1; Region: PFL1; cd01678 766760006291 coenzyme A binding site [chemical binding]; other site 766760006292 active site 766760006293 catalytic residues [active] 766760006294 glycine loop; other site 766760006295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760006296 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 766760006297 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760006298 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760006299 Walker A/P-loop; other site 766760006300 ATP binding site [chemical binding]; other site 766760006301 Q-loop/lid; other site 766760006302 ABC transporter signature motif; other site 766760006303 Walker B; other site 766760006304 D-loop; other site 766760006305 H-loop/switch region; other site 766760006306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760006307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760006308 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 766760006309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760006310 Uncharacterized conserved protein [Function unknown]; Region: COG2427 766760006311 Helix-turn-helix domain; Region: HTH_17; cl17695 766760006312 acetyl-CoA synthetase; Provisional; Region: PRK00174 766760006313 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 766760006314 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 766760006315 acyl-activating enzyme (AAE) consensus motif; other site 766760006316 putative AMP binding site [chemical binding]; other site 766760006317 putative active site [active] 766760006318 putative CoA binding site [chemical binding]; other site 766760006319 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 766760006320 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 766760006321 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 766760006322 enoyl-CoA hydratase; Provisional; Region: PRK07657 766760006323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760006324 substrate binding site [chemical binding]; other site 766760006325 oxyanion hole (OAH) forming residues; other site 766760006326 trimer interface [polypeptide binding]; other site 766760006327 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 766760006328 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 766760006329 active site 766760006330 catalytic residues [active] 766760006331 metal binding site [ion binding]; metal-binding site 766760006332 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 766760006333 carboxyltransferase (CT) interaction site; other site 766760006334 biotinylation site [posttranslational modification]; other site 766760006335 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 766760006336 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760006337 ATP-grasp domain; Region: ATP-grasp_4; cl17255 766760006338 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 766760006339 Condensation domain; Region: Condensation; pfam00668 766760006340 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006341 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760006342 acyl-activating enzyme (AAE) consensus motif; other site 766760006343 AMP binding site [chemical binding]; other site 766760006344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006345 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 766760006346 Condensation domain; Region: Condensation; pfam00668 766760006347 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006348 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006349 acyl-activating enzyme (AAE) consensus motif; other site 766760006350 AMP binding site [chemical binding]; other site 766760006351 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006352 Condensation domain; Region: Condensation; pfam00668 766760006353 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006354 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760006355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006356 acyl-activating enzyme (AAE) consensus motif; other site 766760006357 AMP binding site [chemical binding]; other site 766760006358 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006359 Condensation domain; Region: Condensation; pfam00668 766760006360 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006361 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760006362 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006363 acyl-activating enzyme (AAE) consensus motif; other site 766760006364 AMP binding site [chemical binding]; other site 766760006365 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006366 Condensation domain; Region: Condensation; pfam00668 766760006367 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760006368 Condensation domain; Region: Condensation; pfam00668 766760006369 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006370 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006371 acyl-activating enzyme (AAE) consensus motif; other site 766760006372 AMP binding site [chemical binding]; other site 766760006373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006374 Condensation domain; Region: Condensation; pfam00668 766760006375 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006376 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760006377 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760006378 acyl-activating enzyme (AAE) consensus motif; other site 766760006379 AMP binding site [chemical binding]; other site 766760006380 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006381 Condensation domain; Region: Condensation; pfam00668 766760006382 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760006383 Condensation domain; Region: Condensation; pfam00668 766760006384 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006385 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006386 acyl-activating enzyme (AAE) consensus motif; other site 766760006387 AMP binding site [chemical binding]; other site 766760006388 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006389 Condensation domain; Region: Condensation; pfam00668 766760006390 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006391 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760006392 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006393 acyl-activating enzyme (AAE) consensus motif; other site 766760006394 AMP binding site [chemical binding]; other site 766760006395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006396 Condensation domain; Region: Condensation; pfam00668 766760006397 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760006398 Condensation domain; Region: Condensation; pfam00668 766760006399 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006400 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760006401 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006402 acyl-activating enzyme (AAE) consensus motif; other site 766760006403 AMP binding site [chemical binding]; other site 766760006404 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006405 Condensation domain; Region: Condensation; pfam00668 766760006406 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760006407 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760006408 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760006409 acyl-activating enzyme (AAE) consensus motif; other site 766760006410 AMP binding site [chemical binding]; other site 766760006411 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760006412 Condensation domain; Region: Condensation; pfam00668 766760006413 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760006414 AMP-binding domain protein; Validated; Region: PRK08315 766760006415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 766760006416 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 766760006417 acyl-activating enzyme (AAE) consensus motif; other site 766760006418 putative AMP binding site [chemical binding]; other site 766760006419 putative active site [active] 766760006420 putative CoA binding site [chemical binding]; other site 766760006421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 766760006422 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 766760006423 FAD binding site [chemical binding]; other site 766760006424 homotetramer interface [polypeptide binding]; other site 766760006425 substrate binding pocket [chemical binding]; other site 766760006426 catalytic base [active] 766760006427 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 766760006428 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760006429 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760006430 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 766760006431 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 766760006432 putative catalytic cysteine [active] 766760006433 gamma-glutamyl kinase; Provisional; Region: PRK13402 766760006434 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 766760006435 nucleotide binding site [chemical binding]; other site 766760006436 homotetrameric interface [polypeptide binding]; other site 766760006437 putative phosphate binding site [ion binding]; other site 766760006438 putative allosteric binding site; other site 766760006439 PUA domain; Region: PUA; pfam01472 766760006440 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 766760006441 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 766760006442 Predicted membrane protein [Function unknown]; Region: COG2323 766760006443 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 766760006444 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 766760006445 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 766760006446 Active Sites [active] 766760006447 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 766760006448 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760006449 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760006450 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 766760006451 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 766760006452 active site pocket [active] 766760006453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760006455 putative substrate translocation pore; other site 766760006456 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 766760006457 Ligand binding site; other site 766760006458 Putative Catalytic site; other site 766760006459 DXD motif; other site 766760006460 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 766760006461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 766760006462 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 766760006463 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 766760006464 active site 766760006465 dimer interface [polypeptide binding]; other site 766760006466 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 766760006467 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 766760006468 active site 766760006469 FMN binding site [chemical binding]; other site 766760006470 substrate binding site [chemical binding]; other site 766760006471 3Fe-4S cluster binding site [ion binding]; other site 766760006472 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 766760006473 domain interface; other site 766760006474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760006475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760006476 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 766760006477 putative dimerization interface [polypeptide binding]; other site 766760006478 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 766760006479 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 766760006480 Transcriptional regulators [Transcription]; Region: MarR; COG1846 766760006481 MarR family; Region: MarR_2; pfam12802 766760006482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760006483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760006484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760006485 Walker A/P-loop; other site 766760006486 ATP binding site [chemical binding]; other site 766760006487 Q-loop/lid; other site 766760006488 ABC transporter signature motif; other site 766760006489 Walker B; other site 766760006490 D-loop; other site 766760006491 H-loop/switch region; other site 766760006492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760006493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760006494 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 766760006495 Walker A/P-loop; other site 766760006496 ATP binding site [chemical binding]; other site 766760006497 Q-loop/lid; other site 766760006498 ABC transporter signature motif; other site 766760006499 Walker B; other site 766760006500 D-loop; other site 766760006501 H-loop/switch region; other site 766760006502 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 766760006503 Cytochrome P450; Region: p450; cl12078 766760006504 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 766760006505 classical (c) SDRs; Region: SDR_c; cd05233 766760006506 NAD(P) binding site [chemical binding]; other site 766760006507 active site 766760006508 phosphoenolpyruvate synthase; Validated; Region: PRK06241 766760006509 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 766760006510 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 766760006511 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 766760006512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006513 putative substrate translocation pore; other site 766760006514 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 766760006515 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 766760006516 putative [4Fe-4S] binding site [ion binding]; other site 766760006517 putative molybdopterin cofactor binding site [chemical binding]; other site 766760006518 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 766760006519 putative molybdopterin cofactor binding site; other site 766760006520 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760006521 MarR family; Region: MarR; pfam01047 766760006522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760006524 putative substrate translocation pore; other site 766760006525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006526 Spore germination protein; Region: Spore_permease; pfam03845 766760006527 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 766760006528 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 766760006529 Spore germination protein; Region: Spore_permease; pfam03845 766760006530 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 766760006531 Spore germination protein; Region: Spore_permease; pfam03845 766760006532 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 766760006533 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 766760006534 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760006535 ABC transporter; Region: ABC_tran_2; pfam12848 766760006536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760006537 Tar ligand binding domain homologue; Region: TarH; pfam02203 766760006538 Cache domain; Region: Cache_1; pfam02743 766760006539 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 766760006540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760006541 dimerization interface [polypeptide binding]; other site 766760006542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760006543 dimer interface [polypeptide binding]; other site 766760006544 putative CheW interface [polypeptide binding]; other site 766760006545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760006546 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 766760006547 dimer interface [polypeptide binding]; other site 766760006548 putative tRNA-binding site [nucleotide binding]; other site 766760006549 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 766760006550 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 766760006551 active site 766760006552 catalytic triad [active] 766760006553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760006554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760006555 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760006556 MarR family; Region: MarR; pfam01047 766760006557 Pleckstrin homology-like domain; Region: PH-like; cl17171 766760006558 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 766760006559 DinB superfamily; Region: DinB_2; pfam12867 766760006560 YndJ-like protein; Region: YndJ; pfam14158 766760006561 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 766760006562 DoxX-like family; Region: DoxX_3; pfam13781 766760006563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760006564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760006565 WHG domain; Region: WHG; pfam13305 766760006566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760006567 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 766760006568 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 766760006569 Predicted transcriptional regulator [Transcription]; Region: COG2378 766760006570 HTH domain; Region: HTH_11; pfam08279 766760006571 WYL domain; Region: WYL; pfam13280 766760006572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760006573 dimerization interface [polypeptide binding]; other site 766760006574 putative DNA binding site [nucleotide binding]; other site 766760006575 putative Zn2+ binding site [ion binding]; other site 766760006576 amino acid transporter; Region: 2A0306; TIGR00909 766760006577 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 766760006578 N-acetyl-D-glucosamine binding site [chemical binding]; other site 766760006579 catalytic residue [active] 766760006580 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 766760006581 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 766760006582 NAD(P) binding site [chemical binding]; other site 766760006583 homodimer interface [polypeptide binding]; other site 766760006584 substrate binding site [chemical binding]; other site 766760006585 active site 766760006586 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 766760006587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760006588 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 766760006589 Predicted membrane protein [Function unknown]; Region: COG2322 766760006590 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 766760006591 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 766760006592 putative dimer interface [polypeptide binding]; other site 766760006593 catalytic triad [active] 766760006594 putative transporter; Provisional; Region: PRK10484 766760006595 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 766760006596 Na binding site [ion binding]; other site 766760006597 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760006598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760006599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 766760006600 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 766760006601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760006602 ATP binding site [chemical binding]; other site 766760006603 putative Mg++ binding site [ion binding]; other site 766760006604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760006605 nucleotide binding region [chemical binding]; other site 766760006606 ATP-binding site [chemical binding]; other site 766760006607 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 766760006608 HRDC domain; Region: HRDC; pfam00570 766760006609 Putative motility protein; Region: YjfB_motility; pfam14070 766760006610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 766760006611 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 766760006612 Uncharacterized conserved protein [Function unknown]; Region: COG2427 766760006613 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 766760006614 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 766760006615 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 766760006616 4Fe-4S binding domain; Region: Fer4_6; pfam12837 766760006617 4Fe-4S binding domain; Region: Fer4; pfam00037 766760006618 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 766760006619 [4Fe-4S] binding site [ion binding]; other site 766760006620 molybdopterin cofactor binding site; other site 766760006621 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 766760006622 molybdopterin cofactor binding site; other site 766760006623 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 766760006624 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760006625 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 766760006626 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 766760006627 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 766760006628 Flagellar protein YcgR; Region: YcgR_2; pfam12945 766760006629 PilZ domain; Region: PilZ; pfam07238 766760006630 V-type ATP synthase subunit I; Validated; Region: PRK05771 766760006631 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 766760006632 YCII-related domain; Region: YCII; cl00999 766760006633 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 766760006634 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 766760006635 hypothetical protein; Provisional; Region: PRK08204 766760006636 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 766760006637 active site 766760006638 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 766760006639 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 766760006640 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760006641 TAP-like protein; Region: Abhydrolase_4; pfam08386 766760006642 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 766760006643 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 766760006644 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 766760006645 nudix motif; other site 766760006646 phosphoenolpyruvate synthase; Validated; Region: PRK06241 766760006647 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 766760006648 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 766760006649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760006650 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 766760006651 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 766760006652 DinB family; Region: DinB; cl17821 766760006653 DinB superfamily; Region: DinB_2; pfam12867 766760006654 azoreductase; Provisional; Region: PRK13556 766760006655 Beta-lactamase; Region: Beta-lactamase; pfam00144 766760006656 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 766760006657 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 766760006658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 766760006659 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 766760006660 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 766760006661 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 766760006662 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 766760006663 NAD(P) binding site [chemical binding]; other site 766760006664 catalytic residues [active] 766760006665 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760006666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006667 putative substrate translocation pore; other site 766760006668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760006669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 766760006670 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 766760006671 active site 766760006672 catalytic motif [active] 766760006673 Zn binding site [ion binding]; other site 766760006674 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 766760006675 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 766760006676 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 766760006677 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 766760006678 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 766760006679 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 766760006680 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 766760006681 Na2 binding site [ion binding]; other site 766760006682 putative substrate binding site 1 [chemical binding]; other site 766760006683 Na binding site 1 [ion binding]; other site 766760006684 putative substrate binding site 2 [chemical binding]; other site 766760006685 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 766760006686 Sodium Bile acid symporter family; Region: SBF; pfam01758 766760006687 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 766760006688 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 766760006689 E3 interaction surface; other site 766760006690 lipoyl attachment site [posttranslational modification]; other site 766760006691 e3 binding domain; Region: E3_binding; pfam02817 766760006692 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 766760006693 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 766760006694 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 766760006695 TPP-binding site [chemical binding]; other site 766760006696 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 766760006697 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 766760006698 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 766760006699 metal ion-dependent adhesion site (MIDAS); other site 766760006700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760006701 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760006702 Walker A motif; other site 766760006703 ATP binding site [chemical binding]; other site 766760006704 Walker B motif; other site 766760006705 arginine finger; other site 766760006706 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 766760006707 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 766760006708 E-class dimer interface [polypeptide binding]; other site 766760006709 P-class dimer interface [polypeptide binding]; other site 766760006710 active site 766760006711 Cu2+ binding site [ion binding]; other site 766760006712 Zn2+ binding site [ion binding]; other site 766760006713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760006714 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 766760006715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760006716 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 766760006717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760006718 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760006719 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760006720 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760006721 multidrug efflux protein; Reviewed; Region: PRK01766 766760006722 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 766760006723 cation binding site [ion binding]; other site 766760006724 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 766760006725 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 766760006726 Predicted permeases [General function prediction only]; Region: RarD; COG2962 766760006727 EamA-like transporter family; Region: EamA; pfam00892 766760006728 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 766760006729 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 766760006730 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 766760006731 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760006732 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760006733 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 766760006734 dimer interface [polypeptide binding]; other site 766760006735 FMN binding site [chemical binding]; other site 766760006736 Predicted esterase [General function prediction only]; Region: COG0400 766760006737 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760006738 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 766760006739 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 766760006740 Na binding site [ion binding]; other site 766760006741 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 766760006742 C-terminal peptidase (prc); Region: prc; TIGR00225 766760006743 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 766760006744 protein binding site [polypeptide binding]; other site 766760006745 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 766760006746 Catalytic dyad [active] 766760006747 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760006748 Methyltransferase domain; Region: Methyltransf_31; pfam13847 766760006749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760006750 S-adenosylmethionine binding site [chemical binding]; other site 766760006751 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 766760006752 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 766760006753 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 766760006754 Predicted permeases [General function prediction only]; Region: COG0701 766760006755 TIGR03943 family protein; Region: TIGR03943 766760006756 YodL-like; Region: YodL; pfam14191 766760006757 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 766760006758 active site 766760006759 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 766760006760 YozD-like protein; Region: YozD; pfam14162 766760006761 hypothetical protein; Provisional; Region: PRK13672 766760006762 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 766760006763 toxin interface [polypeptide binding]; other site 766760006764 Zn binding site [ion binding]; other site 766760006765 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 766760006766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760006767 FeS/SAM binding site; other site 766760006768 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 766760006769 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 766760006770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760006771 Coenzyme A binding pocket [chemical binding]; other site 766760006772 acetylornithine deacetylase; Validated; Region: PRK06915 766760006773 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 766760006774 metal binding site [ion binding]; metal-binding site 766760006775 dimer interface [polypeptide binding]; other site 766760006776 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 766760006777 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 766760006778 hypothetical protein; Provisional; Region: PRK06917 766760006779 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760006780 inhibitor-cofactor binding pocket; inhibition site 766760006781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760006782 catalytic residue [active] 766760006783 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760006784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760006785 putative substrate translocation pore; other site 766760006786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760006787 Coenzyme A binding pocket [chemical binding]; other site 766760006788 Family description; Region: UvrD_C_2; pfam13538 766760006789 AAA ATPase domain; Region: AAA_15; pfam13175 766760006790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760006791 Walker A/P-loop; other site 766760006792 ATP binding site [chemical binding]; other site 766760006793 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 766760006794 active site 766760006795 metal binding site [ion binding]; metal-binding site 766760006796 methionine sulfoxide reductase B; Provisional; Region: PRK00222 766760006797 SelR domain; Region: SelR; pfam01641 766760006798 methionine sulfoxide reductase A; Provisional; Region: PRK14054 766760006799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760006800 MarR family; Region: MarR; pfam01047 766760006801 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 766760006802 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 766760006803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 766760006804 metal binding site [ion binding]; metal-binding site 766760006805 active site 766760006806 I-site; other site 766760006807 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 766760006808 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 766760006809 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 766760006810 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 766760006811 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 766760006812 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 766760006813 active site 766760006814 catalytic triad [active] 766760006815 oxyanion hole [active] 766760006816 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 766760006817 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 766760006818 Cu(I) binding site [ion binding]; other site 766760006819 EDD domain protein, DegV family; Region: DegV; TIGR00762 766760006820 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 766760006821 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 766760006822 threonine dehydratase; Validated; Region: PRK08639 766760006823 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 766760006824 tetramer interface [polypeptide binding]; other site 766760006825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760006826 catalytic residue [active] 766760006827 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 766760006828 putative Ile/Val binding site [chemical binding]; other site 766760006829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760006830 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760006831 Walker A motif; other site 766760006832 ATP binding site [chemical binding]; other site 766760006833 Walker B motif; other site 766760006834 arginine finger; other site 766760006835 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 766760006836 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 766760006837 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 766760006838 putative acyl-acceptor binding pocket; other site 766760006839 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 766760006840 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 766760006841 folate binding site [chemical binding]; other site 766760006842 NADP+ binding site [chemical binding]; other site 766760006843 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 766760006844 tetramer interfaces [polypeptide binding]; other site 766760006845 binuclear metal-binding site [ion binding]; other site 766760006846 YpjP-like protein; Region: YpjP; pfam14005 766760006847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760006848 S-adenosylmethionine binding site [chemical binding]; other site 766760006849 Disulphide isomerase; Region: Disulph_isomer; pfam06491 766760006850 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 766760006851 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 766760006852 Virulence factor; Region: Virulence_fact; pfam13769 766760006853 HEAT repeats; Region: HEAT_2; pfam13646 766760006854 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 766760006855 HEAT repeats; Region: HEAT_2; pfam13646 766760006856 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 766760006857 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 766760006858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760006859 Zn2+ binding site [ion binding]; other site 766760006860 Mg2+ binding site [ion binding]; other site 766760006861 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 766760006862 catalytic residues [active] 766760006863 dimer interface [polypeptide binding]; other site 766760006864 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 766760006865 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 766760006866 Potassium binding sites [ion binding]; other site 766760006867 Cesium cation binding sites [ion binding]; other site 766760006868 homoserine O-succinyltransferase; Provisional; Region: PRK05368 766760006869 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 766760006870 proposed active site lysine [active] 766760006871 conserved cys residue [active] 766760006872 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 766760006873 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 766760006874 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 766760006875 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 766760006876 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 766760006877 DNA-binding site [nucleotide binding]; DNA binding site 766760006878 RNA-binding motif; other site 766760006879 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 766760006880 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 766760006881 hypothetical protein; Validated; Region: PRK07708 766760006882 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 766760006883 RNA/DNA hybrid binding site [nucleotide binding]; other site 766760006884 active site 766760006885 conserved hypothetical integral membrane protein; Region: TIGR00697 766760006886 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 766760006887 RNA/DNA hybrid binding site [nucleotide binding]; other site 766760006888 active site 766760006889 5'-3' exonuclease; Region: 53EXOc; smart00475 766760006890 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 766760006891 active site 766760006892 metal binding site 1 [ion binding]; metal-binding site 766760006893 putative 5' ssDNA interaction site; other site 766760006894 metal binding site 3; metal-binding site 766760006895 metal binding site 2 [ion binding]; metal-binding site 766760006896 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 766760006897 putative DNA binding site [nucleotide binding]; other site 766760006898 putative metal binding site [ion binding]; other site 766760006899 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 766760006900 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 766760006901 Dynamin family; Region: Dynamin_N; pfam00350 766760006902 G1 box; other site 766760006903 GTP/Mg2+ binding site [chemical binding]; other site 766760006904 G2 box; other site 766760006905 Switch I region; other site 766760006906 G3 box; other site 766760006907 Switch II region; other site 766760006908 G4 box; other site 766760006909 G5 box; other site 766760006910 Dynamin family; Region: Dynamin_N; pfam00350 766760006911 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 766760006912 G2 box; other site 766760006913 Switch I region; other site 766760006914 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 766760006915 G2 box; other site 766760006916 G3 box; other site 766760006917 Switch II region; other site 766760006918 GTP/Mg2+ binding site [chemical binding]; other site 766760006919 G4 box; other site 766760006920 G5 box; other site 766760006921 Phospholipid methyltransferase; Region: PEMT; cl17370 766760006922 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 766760006923 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 766760006924 malonyl-CoA binding site [chemical binding]; other site 766760006925 dimer interface [polypeptide binding]; other site 766760006926 active site 766760006927 product binding site; other site 766760006928 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760006929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760006930 Coenzyme A binding pocket [chemical binding]; other site 766760006931 xanthine permease; Region: pbuX; TIGR03173 766760006932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760006933 active site 766760006934 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 766760006935 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 766760006936 active site 766760006937 Zn binding site [ion binding]; other site 766760006938 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 766760006939 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 766760006940 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 766760006941 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 766760006942 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 766760006943 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 766760006944 cell division protein GpsB; Provisional; Region: PRK14127 766760006945 DivIVA domain; Region: DivI1A_domain; TIGR03544 766760006946 hypothetical protein; Provisional; Region: PRK13660 766760006947 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 766760006948 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 766760006949 RNase_H superfamily; Region: RNase_H_2; pfam13482 766760006950 active site 766760006951 substrate binding site [chemical binding]; other site 766760006952 catalytic site [active] 766760006953 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 766760006954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760006955 ATP binding site [chemical binding]; other site 766760006956 putative Mg++ binding site [ion binding]; other site 766760006957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760006958 nucleotide binding region [chemical binding]; other site 766760006959 ATP-binding site [chemical binding]; other site 766760006960 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 766760006961 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 766760006962 HPr interaction site; other site 766760006963 glycerol kinase (GK) interaction site [polypeptide binding]; other site 766760006964 active site 766760006965 phosphorylation site [posttranslational modification] 766760006966 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 766760006967 YppG-like protein; Region: YppG; pfam14179 766760006968 YppF-like protein; Region: YppF; pfam14178 766760006969 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 766760006970 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 766760006971 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 766760006972 Transglycosylase; Region: Transgly; pfam00912 766760006973 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 766760006974 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760006975 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 766760006976 Interdomain contacts; other site 766760006977 Cytokine receptor motif; other site 766760006978 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 766760006979 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 766760006980 minor groove reading motif; other site 766760006981 helix-hairpin-helix signature motif; other site 766760006982 substrate binding pocket [chemical binding]; other site 766760006983 active site 766760006984 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 766760006985 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 766760006986 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 766760006987 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 766760006988 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 766760006989 putative dimer interface [polypeptide binding]; other site 766760006990 putative anticodon binding site; other site 766760006991 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 766760006992 homodimer interface [polypeptide binding]; other site 766760006993 motif 1; other site 766760006994 motif 2; other site 766760006995 active site 766760006996 motif 3; other site 766760006997 aspartate aminotransferase; Provisional; Region: PRK05764 766760006998 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760006999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760007000 homodimer interface [polypeptide binding]; other site 766760007001 catalytic residue [active] 766760007002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 766760007003 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 766760007004 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 766760007005 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 766760007006 active site 766760007007 catalytic site [active] 766760007008 substrate binding site [chemical binding]; other site 766760007009 DEAD/DEAH box helicase; Region: DEAD; pfam00270 766760007010 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 766760007011 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 766760007012 tetramerization interface [polypeptide binding]; other site 766760007013 active site 766760007014 pantoate--beta-alanine ligase; Region: panC; TIGR00018 766760007015 Pantoate-beta-alanine ligase; Region: PanC; cd00560 766760007016 active site 766760007017 ATP-binding site [chemical binding]; other site 766760007018 pantoate-binding site; other site 766760007019 HXXH motif; other site 766760007020 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 766760007021 active site 766760007022 oligomerization interface [polypeptide binding]; other site 766760007023 metal binding site [ion binding]; metal-binding site 766760007024 Biotin operon repressor [Transcription]; Region: BirA; COG1654 766760007025 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 766760007026 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 766760007027 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 766760007028 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 766760007029 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 766760007030 active site 766760007031 NTP binding site [chemical binding]; other site 766760007032 metal binding triad [ion binding]; metal-binding site 766760007033 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 766760007034 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 766760007035 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 766760007036 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 766760007037 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 766760007038 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 766760007039 active site 766760007040 dimer interfaces [polypeptide binding]; other site 766760007041 catalytic residues [active] 766760007042 dihydrodipicolinate reductase; Provisional; Region: PRK00048 766760007043 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 766760007044 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 766760007045 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 766760007046 homodimer interface [polypeptide binding]; other site 766760007047 metal binding site [ion binding]; metal-binding site 766760007048 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760007049 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760007050 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760007051 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760007052 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 766760007053 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 766760007054 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 766760007055 Qo binding site; other site 766760007056 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 766760007057 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 766760007058 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 766760007059 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 766760007060 interchain domain interface [polypeptide binding]; other site 766760007061 intrachain domain interface; other site 766760007062 heme bH binding site [chemical binding]; other site 766760007063 Qi binding site; other site 766760007064 heme bL binding site [chemical binding]; other site 766760007065 Qo binding site; other site 766760007066 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 766760007067 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 766760007068 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 766760007069 iron-sulfur cluster [ion binding]; other site 766760007070 [2Fe-2S] cluster binding site [ion binding]; other site 766760007071 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 766760007072 hypothetical protein; Provisional; Region: PRK03636 766760007073 UPF0302 domain; Region: UPF0302; pfam08864 766760007074 IDEAL domain; Region: IDEAL; pfam08858 766760007075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760007076 TPR motif; other site 766760007077 binding surface 766760007078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760007079 binding surface 766760007080 TPR motif; other site 766760007081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760007082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760007083 binding surface 766760007084 TPR motif; other site 766760007085 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 766760007086 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 766760007087 hinge; other site 766760007088 active site 766760007089 prephenate dehydrogenase; Validated; Region: PRK06545 766760007090 prephenate dehydrogenase; Validated; Region: PRK08507 766760007091 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 766760007092 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 766760007093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760007094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760007095 homodimer interface [polypeptide binding]; other site 766760007096 catalytic residue [active] 766760007097 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 766760007098 substrate binding site [chemical binding]; other site 766760007099 active site 766760007100 catalytic residues [active] 766760007101 heterodimer interface [polypeptide binding]; other site 766760007102 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 766760007103 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 766760007104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760007105 catalytic residue [active] 766760007106 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 766760007107 active site 766760007108 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 766760007109 active site 766760007110 ribulose/triose binding site [chemical binding]; other site 766760007111 phosphate binding site [ion binding]; other site 766760007112 substrate (anthranilate) binding pocket [chemical binding]; other site 766760007113 product (indole) binding pocket [chemical binding]; other site 766760007114 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 766760007115 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 766760007116 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 766760007117 anthranilate synthase component I; Provisional; Region: PRK13569 766760007118 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 766760007119 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 766760007120 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 766760007121 homotrimer interaction site [polypeptide binding]; other site 766760007122 active site 766760007123 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 766760007124 active site 766760007125 dimer interface [polypeptide binding]; other site 766760007126 metal binding site [ion binding]; metal-binding site 766760007127 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 766760007128 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 766760007129 Tetramer interface [polypeptide binding]; other site 766760007130 active site 766760007131 FMN-binding site [chemical binding]; other site 766760007132 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 766760007133 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 766760007134 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 766760007135 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 766760007136 active site 766760007137 multimer interface [polypeptide binding]; other site 766760007138 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 766760007139 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 766760007140 substrate binding pocket [chemical binding]; other site 766760007141 chain length determination region; other site 766760007142 substrate-Mg2+ binding site; other site 766760007143 catalytic residues [active] 766760007144 aspartate-rich region 1; other site 766760007145 active site lid residues [active] 766760007146 aspartate-rich region 2; other site 766760007147 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 766760007148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760007149 S-adenosylmethionine binding site [chemical binding]; other site 766760007150 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 766760007151 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 766760007152 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 766760007153 homodecamer interface [polypeptide binding]; other site 766760007154 GTP cyclohydrolase I; Provisional; Region: PLN03044 766760007155 active site 766760007156 putative catalytic site residues [active] 766760007157 zinc binding site [ion binding]; other site 766760007158 GTP-CH-I/GFRP interaction surface; other site 766760007159 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 766760007160 IHF dimer interface [polypeptide binding]; other site 766760007161 IHF - DNA interface [nucleotide binding]; other site 766760007162 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 766760007163 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 766760007164 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 766760007165 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 766760007166 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 766760007167 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 766760007168 GTP-binding protein Der; Reviewed; Region: PRK00093 766760007169 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 766760007170 G1 box; other site 766760007171 GTP/Mg2+ binding site [chemical binding]; other site 766760007172 Switch I region; other site 766760007173 G2 box; other site 766760007174 Switch II region; other site 766760007175 G3 box; other site 766760007176 G4 box; other site 766760007177 G5 box; other site 766760007178 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 766760007179 G1 box; other site 766760007180 GTP/Mg2+ binding site [chemical binding]; other site 766760007181 Switch I region; other site 766760007182 G2 box; other site 766760007183 G3 box; other site 766760007184 Switch II region; other site 766760007185 G4 box; other site 766760007186 G5 box; other site 766760007187 YIEGIA protein; Region: YIEGIA; pfam14045 766760007188 YpzI-like protein; Region: YpzI; pfam14140 766760007189 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 766760007190 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 766760007191 homotetramer interface [polypeptide binding]; other site 766760007192 FMN binding site [chemical binding]; other site 766760007193 homodimer contacts [polypeptide binding]; other site 766760007194 putative active site [active] 766760007195 putative substrate binding site [chemical binding]; other site 766760007196 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 766760007197 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 766760007198 RNA binding site [nucleotide binding]; other site 766760007199 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 766760007200 RNA binding site [nucleotide binding]; other site 766760007201 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 766760007202 RNA binding site [nucleotide binding]; other site 766760007203 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 766760007204 RNA binding site [nucleotide binding]; other site 766760007205 cytidylate kinase; Provisional; Region: cmk; PRK00023 766760007206 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 766760007207 CMP-binding site; other site 766760007208 The sites determining sugar specificity; other site 766760007209 germination protein YpeB; Region: spore_YpeB; TIGR02889 766760007210 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760007211 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 766760007212 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 766760007213 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 766760007214 active site 766760007215 homotetramer interface [polypeptide binding]; other site 766760007216 homodimer interface [polypeptide binding]; other site 766760007217 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 766760007218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 766760007219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760007220 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 766760007221 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 766760007222 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 766760007223 NAD(P) binding site [chemical binding]; other site 766760007224 adaptor protein; Provisional; Region: PRK02899 766760007225 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 766760007226 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 766760007227 putative active site [active] 766760007228 putative metal binding site [ion binding]; other site 766760007229 Transposase domain (DUF772); Region: DUF772; pfam05598 766760007230 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760007231 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760007232 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 766760007233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760007234 CAAX protease self-immunity; Region: Abi; pfam02517 766760007235 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 766760007236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760007237 ATP binding site [chemical binding]; other site 766760007238 putative Mg++ binding site [ion binding]; other site 766760007239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760007240 nucleotide binding region [chemical binding]; other site 766760007241 ATP-binding site [chemical binding]; other site 766760007242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 766760007243 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 766760007244 Predicted membrane protein [Function unknown]; Region: COG3601 766760007245 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 766760007246 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 766760007247 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 766760007248 ligand binding site [chemical binding]; other site 766760007249 NAD binding site [chemical binding]; other site 766760007250 dimerization interface [polypeptide binding]; other site 766760007251 catalytic site [active] 766760007252 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 766760007253 putative L-serine binding site [chemical binding]; other site 766760007254 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 766760007255 Peptidase family M23; Region: Peptidase_M23; pfam01551 766760007256 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760007257 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 766760007258 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760007259 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 766760007260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760007261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760007262 DNA binding residues [nucleotide binding] 766760007263 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 766760007264 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 766760007265 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 766760007266 NodB motif; other site 766760007267 active site 766760007268 catalytic site [active] 766760007269 Zn binding site [ion binding]; other site 766760007270 FOG: WD40 repeat [General function prediction only]; Region: COG2319 766760007271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760007272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760007273 dimerization interface [polypeptide binding]; other site 766760007274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760007275 dimer interface [polypeptide binding]; other site 766760007276 phosphorylation site [posttranslational modification] 766760007277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760007278 ATP binding site [chemical binding]; other site 766760007279 Mg2+ binding site [ion binding]; other site 766760007280 G-X-G motif; other site 766760007281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760007282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760007283 active site 766760007284 phosphorylation site [posttranslational modification] 766760007285 intermolecular recognition site; other site 766760007286 dimerization interface [polypeptide binding]; other site 766760007287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760007288 DNA binding site [nucleotide binding] 766760007289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 766760007290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760007291 dimerization interface [polypeptide binding]; other site 766760007292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760007293 putative active site [active] 766760007294 heme pocket [chemical binding]; other site 766760007295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760007296 dimer interface [polypeptide binding]; other site 766760007297 phosphorylation site [posttranslational modification] 766760007298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760007299 ATP binding site [chemical binding]; other site 766760007300 Mg2+ binding site [ion binding]; other site 766760007301 G-X-G motif; other site 766760007302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760007303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760007304 active site 766760007305 phosphorylation site [posttranslational modification] 766760007306 intermolecular recognition site; other site 766760007307 dimerization interface [polypeptide binding]; other site 766760007308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760007309 DNA binding site [nucleotide binding] 766760007310 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 766760007311 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 766760007312 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 766760007313 ResB-like family; Region: ResB; pfam05140 766760007314 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 766760007315 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 766760007316 catalytic residues [active] 766760007317 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 766760007318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760007319 RNA binding surface [nucleotide binding]; other site 766760007320 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 766760007321 active site 766760007322 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 766760007323 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 766760007324 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 766760007325 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 766760007326 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 766760007327 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 766760007328 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 766760007329 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 766760007330 Transposase domain (DUF772); Region: DUF772; pfam05598 766760007331 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760007332 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760007333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760007334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760007335 Coenzyme A binding pocket [chemical binding]; other site 766760007336 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 766760007337 homopentamer interface [polypeptide binding]; other site 766760007338 active site 766760007339 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 766760007340 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 766760007341 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 766760007342 dimerization interface [polypeptide binding]; other site 766760007343 active site 766760007344 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 766760007345 Lumazine binding domain; Region: Lum_binding; pfam00677 766760007346 Lumazine binding domain; Region: Lum_binding; pfam00677 766760007347 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 766760007348 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 766760007349 catalytic motif [active] 766760007350 Zn binding site [ion binding]; other site 766760007351 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 766760007352 AAA domain; Region: AAA_33; pfam13671 766760007353 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 766760007354 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 766760007355 active site 766760007356 metal binding site [ion binding]; metal-binding site 766760007357 RNA ligase; Region: RNA_lig_T4_1; pfam09511 766760007358 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760007359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760007360 TPR motif; other site 766760007361 binding surface 766760007362 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760007363 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 766760007364 active site 766760007365 Predicted secreted protein [Function unknown]; Region: COG4086 766760007366 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 766760007367 Protein of unknown function (DUF867); Region: DUF867; pfam05908 766760007368 diaminopimelate decarboxylase; Region: lysA; TIGR01048 766760007369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 766760007370 active site 766760007371 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 766760007372 substrate binding site [chemical binding]; other site 766760007373 catalytic residues [active] 766760007374 dimer interface [polypeptide binding]; other site 766760007375 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 766760007376 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 766760007377 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 766760007378 stage V sporulation protein AD; Validated; Region: PRK08304 766760007379 stage V sporulation protein AD; Provisional; Region: PRK12404 766760007380 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 766760007381 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 766760007382 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 766760007383 sporulation sigma factor SigF; Validated; Region: PRK05572 766760007384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760007385 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 766760007386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760007387 DNA binding residues [nucleotide binding] 766760007388 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 766760007389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760007390 ATP binding site [chemical binding]; other site 766760007391 Mg2+ binding site [ion binding]; other site 766760007392 G-X-G motif; other site 766760007393 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 766760007394 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 766760007395 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 766760007396 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 766760007397 purine nucleoside phosphorylase; Provisional; Region: PRK08202 766760007398 phosphopentomutase; Provisional; Region: PRK05362 766760007399 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 766760007400 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 766760007401 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 766760007402 active site 766760007403 Int/Topo IB signature motif; other site 766760007404 ferric uptake regulator; Provisional; Region: fur; PRK09462 766760007405 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 766760007406 metal binding site 2 [ion binding]; metal-binding site 766760007407 putative DNA binding helix; other site 766760007408 metal binding site 1 [ion binding]; metal-binding site 766760007409 dimer interface [polypeptide binding]; other site 766760007410 structural Zn2+ binding site [ion binding]; other site 766760007411 stage II sporulation protein M; Region: spo_II_M; TIGR02831 766760007412 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 766760007413 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 766760007414 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 766760007415 active site 766760007416 P-loop; other site 766760007417 phosphorylation site [posttranslational modification] 766760007418 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 766760007419 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 766760007420 Na binding site [ion binding]; other site 766760007421 putative substrate binding site [chemical binding]; other site 766760007422 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760007423 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 766760007424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760007425 Coenzyme A binding pocket [chemical binding]; other site 766760007426 TIGR00375 family protein; Region: TIGR00375 766760007427 PHP-associated; Region: PHP_C; pfam13263 766760007428 Transcription elongation factor Spt4; Region: Spt4; cl12033 766760007429 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 766760007430 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 766760007431 dimer interface [polypeptide binding]; other site 766760007432 ADP-ribose binding site [chemical binding]; other site 766760007433 active site 766760007434 nudix motif; other site 766760007435 metal binding site [ion binding]; metal-binding site 766760007436 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 766760007437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760007438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760007439 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 766760007440 DoxX-like family; Region: DoxX_2; pfam13564 766760007441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 766760007442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 766760007443 active site 766760007444 catalytic tetrad [active] 766760007445 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 766760007446 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 766760007447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 766760007448 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 766760007449 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 766760007450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 766760007451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760007452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760007453 Coenzyme A binding pocket [chemical binding]; other site 766760007454 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 766760007455 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 766760007456 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 766760007457 Lipase (class 2); Region: Lipase_2; pfam01674 766760007458 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 766760007459 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 766760007460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 766760007461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760007462 dimer interface [polypeptide binding]; other site 766760007463 conserved gate region; other site 766760007464 putative PBP binding loops; other site 766760007465 ABC-ATPase subunit interface; other site 766760007466 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 766760007467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760007468 dimer interface [polypeptide binding]; other site 766760007469 conserved gate region; other site 766760007470 putative PBP binding loops; other site 766760007471 ABC-ATPase subunit interface; other site 766760007472 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 766760007473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760007474 Walker A/P-loop; other site 766760007475 ATP binding site [chemical binding]; other site 766760007476 Q-loop/lid; other site 766760007477 ABC transporter signature motif; other site 766760007478 Walker B; other site 766760007479 D-loop; other site 766760007480 H-loop/switch region; other site 766760007481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 766760007482 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 766760007483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760007484 Walker A/P-loop; other site 766760007485 ATP binding site [chemical binding]; other site 766760007486 Q-loop/lid; other site 766760007487 ABC transporter signature motif; other site 766760007488 Walker B; other site 766760007489 D-loop; other site 766760007490 H-loop/switch region; other site 766760007491 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 766760007492 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 766760007493 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 766760007494 YolD-like protein; Region: YolD; pfam08863 766760007495 DNA polymerase IV; Reviewed; Region: PRK03103 766760007496 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 766760007497 active site 766760007498 DNA binding site [nucleotide binding] 766760007499 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 766760007500 YqzH-like protein; Region: YqzH; pfam14164 766760007501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760007502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760007503 putative substrate translocation pore; other site 766760007504 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 766760007505 putative dimer interface [polypeptide binding]; other site 766760007506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760007507 ligand binding site [chemical binding]; other site 766760007508 Zn binding site [ion binding]; other site 766760007509 pantothenate kinase; Provisional; Region: PRK05439 766760007510 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 766760007511 ATP-binding site [chemical binding]; other site 766760007512 CoA-binding site [chemical binding]; other site 766760007513 Mg2+-binding site [ion binding]; other site 766760007514 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 766760007515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760007516 Walker A/P-loop; other site 766760007517 ATP binding site [chemical binding]; other site 766760007518 Q-loop/lid; other site 766760007519 ABC transporter signature motif; other site 766760007520 Walker B; other site 766760007521 D-loop; other site 766760007522 H-loop/switch region; other site 766760007523 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 766760007524 active site 766760007525 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 766760007526 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760007527 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 766760007528 Walker A/P-loop; other site 766760007529 ATP binding site [chemical binding]; other site 766760007530 Q-loop/lid; other site 766760007531 ABC transporter signature motif; other site 766760007532 Walker B; other site 766760007533 D-loop; other site 766760007534 H-loop/switch region; other site 766760007535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760007536 HAMP domain; Region: HAMP; pfam00672 766760007537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760007538 dimer interface [polypeptide binding]; other site 766760007539 phosphorylation site [posttranslational modification] 766760007540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760007541 ATP binding site [chemical binding]; other site 766760007542 Mg2+ binding site [ion binding]; other site 766760007543 G-X-G motif; other site 766760007544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760007545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760007546 active site 766760007547 phosphorylation site [posttranslational modification] 766760007548 intermolecular recognition site; other site 766760007549 dimerization interface [polypeptide binding]; other site 766760007550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760007551 DNA binding site [nucleotide binding] 766760007552 Condensation domain; Region: Condensation; pfam00668 766760007553 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760007554 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760007555 acyl-activating enzyme (AAE) consensus motif; other site 766760007556 AMP binding site [chemical binding]; other site 766760007557 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007558 peptide synthase; Provisional; Region: PRK12316 766760007559 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760007560 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007561 acyl-activating enzyme (AAE) consensus motif; other site 766760007562 AMP binding site [chemical binding]; other site 766760007563 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007564 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760007565 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007566 acyl-activating enzyme (AAE) consensus motif; other site 766760007567 AMP binding site [chemical binding]; other site 766760007568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007569 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760007570 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007571 acyl-activating enzyme (AAE) consensus motif; other site 766760007572 AMP binding site [chemical binding]; other site 766760007573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007574 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760007575 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007576 acyl-activating enzyme (AAE) consensus motif; other site 766760007577 AMP binding site [chemical binding]; other site 766760007578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007579 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 766760007580 Condensation domain; Region: Condensation; pfam00668 766760007581 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760007582 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760007583 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007584 acyl-activating enzyme (AAE) consensus motif; other site 766760007585 AMP binding site [chemical binding]; other site 766760007586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007587 Condensation domain; Region: Condensation; pfam00668 766760007588 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760007589 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760007590 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007591 acyl-activating enzyme (AAE) consensus motif; other site 766760007592 AMP binding site [chemical binding]; other site 766760007593 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007594 Condensation domain; Region: Condensation; pfam00668 766760007595 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760007596 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760007597 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 766760007598 acyl-activating enzyme (AAE) consensus motif; other site 766760007599 AMP binding site [chemical binding]; other site 766760007600 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007601 Condensation domain; Region: Condensation; pfam00668 766760007602 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 766760007603 Nonribosomal peptide synthase; Region: NRPS; pfam08415 766760007604 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 766760007605 acyl-activating enzyme (AAE) consensus motif; other site 766760007606 AMP binding site [chemical binding]; other site 766760007607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007608 peptide synthase; Provisional; Region: PRK12467 766760007609 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760007610 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007611 acyl-activating enzyme (AAE) consensus motif; other site 766760007612 AMP binding site [chemical binding]; other site 766760007613 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007614 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760007615 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760007616 acyl-activating enzyme (AAE) consensus motif; other site 766760007617 AMP binding site [chemical binding]; other site 766760007618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007619 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 766760007620 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 766760007621 acyl-activating enzyme (AAE) consensus motif; other site 766760007622 AMP binding site [chemical binding]; other site 766760007623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760007624 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 766760007625 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760007626 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 766760007627 Protein of unknown function (DUF867); Region: DUF867; pfam05908 766760007628 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 766760007629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760007630 NAD(P) binding site [chemical binding]; other site 766760007631 active site 766760007632 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 766760007633 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 766760007634 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 766760007635 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 766760007636 putative metal binding site [ion binding]; other site 766760007637 putative dimer interface [polypeptide binding]; other site 766760007638 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 766760007639 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 766760007640 active site 766760007641 FMN binding site [chemical binding]; other site 766760007642 substrate binding site [chemical binding]; other site 766760007643 homotetramer interface [polypeptide binding]; other site 766760007644 catalytic residue [active] 766760007645 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760007646 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 766760007647 ribonuclease Z; Region: RNase_Z; TIGR02651 766760007648 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 766760007649 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 766760007650 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 766760007651 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 766760007652 DctM-like transporters; Region: DctM; pfam06808 766760007653 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 766760007654 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 766760007655 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 766760007656 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 766760007657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760007658 DNA-binding site [nucleotide binding]; DNA binding site 766760007659 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 766760007660 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 766760007661 beta-galactosidase; Region: BGL; TIGR03356 766760007662 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 766760007663 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 766760007664 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 766760007665 active site 766760007666 methionine cluster; other site 766760007667 phosphorylation site [posttranslational modification] 766760007668 metal binding site [ion binding]; metal-binding site 766760007669 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 766760007670 active site 766760007671 P-loop; other site 766760007672 phosphorylation site [posttranslational modification] 766760007673 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 766760007674 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 766760007675 dimer interface [polypeptide binding]; other site 766760007676 active site 766760007677 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 766760007678 glucose-1-dehydrogenase; Provisional; Region: PRK08936 766760007679 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 766760007680 NAD binding site [chemical binding]; other site 766760007681 homodimer interface [polypeptide binding]; other site 766760007682 active site 766760007683 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 766760007684 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 766760007685 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 766760007686 DNA polymerase IV; Validated; Region: PRK01810 766760007687 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 766760007688 active site 766760007689 DNA binding site [nucleotide binding] 766760007690 OxaA-like protein precursor; Validated; Region: PRK01622 766760007691 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 766760007692 peptidase T-like protein; Region: PepT-like; TIGR01883 766760007693 metal binding site [ion binding]; metal-binding site 766760007694 putative dimer interface [polypeptide binding]; other site 766760007695 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 766760007696 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 766760007697 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 766760007698 Predicted membrane protein [Function unknown]; Region: COG4129 766760007699 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 766760007700 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 766760007701 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 766760007702 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 766760007703 Walker A/P-loop; other site 766760007704 ATP binding site [chemical binding]; other site 766760007705 Q-loop/lid; other site 766760007706 ABC transporter signature motif; other site 766760007707 Walker B; other site 766760007708 D-loop; other site 766760007709 H-loop/switch region; other site 766760007710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760007711 dimer interface [polypeptide binding]; other site 766760007712 conserved gate region; other site 766760007713 putative PBP binding loops; other site 766760007714 ABC-ATPase subunit interface; other site 766760007715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 766760007716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 766760007717 substrate binding pocket [chemical binding]; other site 766760007718 membrane-bound complex binding site; other site 766760007719 hinge residues; other site 766760007720 Disulphide isomerase; Region: Disulph_isomer; pfam06491 766760007721 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 766760007722 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 766760007723 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 766760007724 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 766760007725 E3 interaction surface; other site 766760007726 lipoyl attachment site [posttranslational modification]; other site 766760007727 e3 binding domain; Region: E3_binding; pfam02817 766760007728 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 766760007729 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 766760007730 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 766760007731 alpha subunit interface [polypeptide binding]; other site 766760007732 TPP binding site [chemical binding]; other site 766760007733 heterodimer interface [polypeptide binding]; other site 766760007734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 766760007735 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 766760007736 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 766760007737 tetramer interface [polypeptide binding]; other site 766760007738 TPP-binding site [chemical binding]; other site 766760007739 heterodimer interface [polypeptide binding]; other site 766760007740 phosphorylation loop region [posttranslational modification] 766760007741 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 766760007742 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 766760007743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760007744 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 766760007745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 766760007746 nucleotide binding site [chemical binding]; other site 766760007747 Acetokinase family; Region: Acetate_kinase; cl17229 766760007748 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 766760007749 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 766760007750 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 766760007751 NAD binding site [chemical binding]; other site 766760007752 Phe binding site; other site 766760007753 phosphate butyryltransferase; Validated; Region: PRK07742 766760007754 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 766760007755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760007756 putative active site [active] 766760007757 heme pocket [chemical binding]; other site 766760007758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760007759 putative active site [active] 766760007760 heme pocket [chemical binding]; other site 766760007761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760007762 Walker A motif; other site 766760007763 ATP binding site [chemical binding]; other site 766760007764 Walker B motif; other site 766760007765 arginine finger; other site 766760007766 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 766760007767 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 766760007768 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 766760007769 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 766760007770 active site 766760007771 catalytic site [active] 766760007772 metal binding site [ion binding]; metal-binding site 766760007773 dimer interface [polypeptide binding]; other site 766760007774 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 766760007775 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 766760007776 active site 766760007777 metal binding site [ion binding]; metal-binding site 766760007778 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 766760007779 trimer interface [polypeptide binding]; other site 766760007780 active site 766760007781 substrate binding site [chemical binding]; other site 766760007782 CoA binding site [chemical binding]; other site 766760007783 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 766760007784 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 766760007785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760007786 active site 766760007787 phosphorylation site [posttranslational modification] 766760007788 intermolecular recognition site; other site 766760007789 dimerization interface [polypeptide binding]; other site 766760007790 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 766760007791 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 766760007792 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 766760007793 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 766760007794 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 766760007795 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 766760007796 Walker A/P-loop; other site 766760007797 ATP binding site [chemical binding]; other site 766760007798 Q-loop/lid; other site 766760007799 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 766760007800 ABC transporter signature motif; other site 766760007801 Walker B; other site 766760007802 D-loop; other site 766760007803 H-loop/switch region; other site 766760007804 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 766760007805 arginine repressor; Provisional; Region: PRK04280 766760007806 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 766760007807 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 766760007808 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760007809 RNA binding surface [nucleotide binding]; other site 766760007810 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 766760007811 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 766760007812 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 766760007813 TPP-binding site; other site 766760007814 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 766760007815 PYR/PP interface [polypeptide binding]; other site 766760007816 dimer interface [polypeptide binding]; other site 766760007817 TPP binding site [chemical binding]; other site 766760007818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 766760007819 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 766760007820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 766760007821 substrate binding pocket [chemical binding]; other site 766760007822 chain length determination region; other site 766760007823 substrate-Mg2+ binding site; other site 766760007824 catalytic residues [active] 766760007825 aspartate-rich region 1; other site 766760007826 active site lid residues [active] 766760007827 aspartate-rich region 2; other site 766760007828 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 766760007829 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 766760007830 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 766760007831 generic binding surface II; other site 766760007832 generic binding surface I; other site 766760007833 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 766760007834 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 766760007835 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 766760007836 homodimer interface [polypeptide binding]; other site 766760007837 NADP binding site [chemical binding]; other site 766760007838 substrate binding site [chemical binding]; other site 766760007839 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 766760007840 putative RNA binding site [nucleotide binding]; other site 766760007841 Asp23 family; Region: Asp23; pfam03780 766760007842 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 766760007843 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 766760007844 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 766760007845 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 766760007846 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 766760007847 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 766760007848 carboxyltransferase (CT) interaction site; other site 766760007849 biotinylation site [posttranslational modification]; other site 766760007850 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 766760007851 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 766760007852 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 766760007853 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 766760007854 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 766760007855 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 766760007856 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 766760007857 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 766760007858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760007859 Walker A motif; other site 766760007860 ATP binding site [chemical binding]; other site 766760007861 Walker B motif; other site 766760007862 arginine finger; other site 766760007863 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 766760007864 elongation factor P; Validated; Region: PRK00529 766760007865 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 766760007866 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 766760007867 RNA binding site [nucleotide binding]; other site 766760007868 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 766760007869 RNA binding site [nucleotide binding]; other site 766760007870 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 766760007871 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 766760007872 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 766760007873 active site 766760007874 Dehydroquinase class II; Region: DHquinase_II; pfam01220 766760007875 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 766760007876 trimer interface [polypeptide binding]; other site 766760007877 active site 766760007878 dimer interface [polypeptide binding]; other site 766760007879 Conserved membrane protein YqhR; Region: YqhR; pfam11085 766760007880 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 766760007881 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 766760007882 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 766760007883 active site 766760007884 nucleophile elbow; other site 766760007885 manganese transport transcriptional regulator; Provisional; Region: PRK03902 766760007886 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 766760007887 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 766760007888 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 766760007889 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 766760007890 active site residue [active] 766760007891 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 766760007892 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 766760007893 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 766760007894 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 766760007895 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 766760007896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760007897 dimer interface [polypeptide binding]; other site 766760007898 conserved gate region; other site 766760007899 putative PBP binding loops; other site 766760007900 ABC-ATPase subunit interface; other site 766760007901 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 766760007902 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 766760007903 Walker A/P-loop; other site 766760007904 ATP binding site [chemical binding]; other site 766760007905 Q-loop/lid; other site 766760007906 ABC transporter signature motif; other site 766760007907 Walker B; other site 766760007908 D-loop; other site 766760007909 H-loop/switch region; other site 766760007910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 766760007911 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 766760007912 tetramer interface [polypeptide binding]; other site 766760007913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760007914 catalytic residue [active] 766760007915 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 766760007916 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 766760007917 tetramer interface [polypeptide binding]; other site 766760007918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760007919 catalytic residue [active] 766760007920 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 766760007921 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 766760007922 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 766760007923 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 766760007924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760007925 ATP binding site [chemical binding]; other site 766760007926 putative Mg++ binding site [ion binding]; other site 766760007927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760007928 nucleotide binding region [chemical binding]; other site 766760007929 ATP-binding site [chemical binding]; other site 766760007930 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 766760007931 Anti-repressor SinI; Region: SinI; pfam08671 766760007932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760007933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760007934 non-specific DNA binding site [nucleotide binding]; other site 766760007935 salt bridge; other site 766760007936 sequence-specific DNA binding site [nucleotide binding]; other site 766760007937 Anti-repressor SinI; Region: SinI; pfam08671 766760007938 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 766760007939 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 766760007940 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 766760007941 Catalytic site [active] 766760007942 YqxM protein; Region: YqxM_for_SipW; TIGR04087 766760007943 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 766760007944 YqzE-like protein; Region: YqzE; pfam14038 766760007945 ComG operon protein 7; Region: ComGG; pfam14173 766760007946 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 766760007947 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 766760007948 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 766760007949 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 766760007950 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 766760007951 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 766760007952 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 766760007953 Type II/IV secretion system protein; Region: T2SE; pfam00437 766760007954 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 766760007955 Walker A motif; other site 766760007956 ATP binding site [chemical binding]; other site 766760007957 Walker B motif; other site 766760007958 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 766760007959 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 766760007960 ArsC family; Region: ArsC; pfam03960 766760007961 putative catalytic residues [active] 766760007962 thiol/disulfide switch; other site 766760007963 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 766760007964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760007965 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 766760007966 Domain of unknown function DUF77; Region: DUF77; pfam01910 766760007967 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 766760007968 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 766760007969 putative active site [active] 766760007970 Zn binding site [ion binding]; other site 766760007971 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 766760007972 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 766760007973 putative ligand binding residues [chemical binding]; other site 766760007974 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 766760007975 Sulfatase; Region: Sulfatase; pfam00884 766760007976 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 766760007977 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 766760007978 nucleotide binding site [chemical binding]; other site 766760007979 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 766760007980 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 766760007981 Rhomboid family; Region: Rhomboid; pfam01694 766760007982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760007983 binding surface 766760007984 TPR motif; other site 766760007985 Tetratricopeptide repeat; Region: TPR_16; pfam13432 766760007986 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 766760007987 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 766760007988 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 766760007989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760007990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 766760007991 YceG-like family; Region: YceG; pfam02618 766760007992 Integral membrane protein DUF95; Region: DUF95; pfam01944 766760007993 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 766760007994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760007995 Walker A/P-loop; other site 766760007996 ATP binding site [chemical binding]; other site 766760007997 Q-loop/lid; other site 766760007998 ABC transporter signature motif; other site 766760007999 Walker B; other site 766760008000 D-loop; other site 766760008001 H-loop/switch region; other site 766760008002 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 766760008003 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 766760008004 Walker A/P-loop; other site 766760008005 ATP binding site [chemical binding]; other site 766760008006 Q-loop/lid; other site 766760008007 ABC transporter signature motif; other site 766760008008 Walker B; other site 766760008009 D-loop; other site 766760008010 H-loop/switch region; other site 766760008011 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 766760008012 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 766760008013 Walker A/P-loop; other site 766760008014 ATP binding site [chemical binding]; other site 766760008015 Q-loop/lid; other site 766760008016 ABC transporter signature motif; other site 766760008017 Walker B; other site 766760008018 D-loop; other site 766760008019 H-loop/switch region; other site 766760008020 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 766760008021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760008022 dimer interface [polypeptide binding]; other site 766760008023 conserved gate region; other site 766760008024 ABC-ATPase subunit interface; other site 766760008025 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 766760008026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760008027 dimer interface [polypeptide binding]; other site 766760008028 conserved gate region; other site 766760008029 putative PBP binding loops; other site 766760008030 ABC-ATPase subunit interface; other site 766760008031 PBP superfamily domain; Region: PBP_like_2; cl17296 766760008032 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 766760008033 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 766760008034 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 766760008035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760008036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760008037 putative substrate translocation pore; other site 766760008038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760008039 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 766760008040 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 766760008041 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 766760008042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 766760008043 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 766760008044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 766760008045 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 766760008046 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 766760008047 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 766760008048 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 766760008049 Uncharacterized conserved protein [Function unknown]; Region: COG5663 766760008050 ferric uptake regulator; Provisional; Region: fur; PRK09462 766760008051 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 766760008052 metal binding site 2 [ion binding]; metal-binding site 766760008053 putative DNA binding helix; other site 766760008054 metal binding site 1 [ion binding]; metal-binding site 766760008055 dimer interface [polypeptide binding]; other site 766760008056 structural Zn2+ binding site [ion binding]; other site 766760008057 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 766760008058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760008059 ABC-ATPase subunit interface; other site 766760008060 dimer interface [polypeptide binding]; other site 766760008061 putative PBP binding regions; other site 766760008062 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 766760008063 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 766760008064 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760008065 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760008066 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760008067 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 766760008068 endonuclease IV; Provisional; Region: PRK01060 766760008069 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 766760008070 AP (apurinic/apyrimidinic) site pocket; other site 766760008071 DNA interaction; other site 766760008072 Metal-binding active site; metal-binding site 766760008073 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 766760008074 DEAD-like helicases superfamily; Region: DEXDc; smart00487 766760008075 ATP binding site [chemical binding]; other site 766760008076 Mg++ binding site [ion binding]; other site 766760008077 motif III; other site 766760008078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760008079 nucleotide binding region [chemical binding]; other site 766760008080 ATP-binding site [chemical binding]; other site 766760008081 YqfQ-like protein; Region: YqfQ; pfam14181 766760008082 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 766760008083 LytB protein; Region: LYTB; pfam02401 766760008084 Uncharacterized conserved protein [Function unknown]; Region: COG0327 766760008085 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 766760008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 766760008087 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 766760008088 Uncharacterized conserved protein [Function unknown]; Region: COG0327 766760008089 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 766760008090 Family of unknown function (DUF633); Region: DUF633; pfam04816 766760008091 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 766760008092 Active_site [active] 766760008093 Immunity protein Imm6; Region: Imm6; pfam14434 766760008094 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760008095 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 766760008096 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 766760008097 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 766760008098 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 766760008099 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 766760008100 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 766760008101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760008102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 766760008103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760008104 DNA binding residues [nucleotide binding] 766760008105 DNA primase; Validated; Region: dnaG; PRK05667 766760008106 CHC2 zinc finger; Region: zf-CHC2; pfam01807 766760008107 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 766760008108 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 766760008109 active site 766760008110 metal binding site [ion binding]; metal-binding site 766760008111 interdomain interaction site; other site 766760008112 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 766760008113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 766760008114 PEP synthetase regulatory protein; Provisional; Region: PRK05339 766760008115 HTH domain; Region: HTH_11; pfam08279 766760008116 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 766760008117 FOG: CBS domain [General function prediction only]; Region: COG0517 766760008118 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 766760008119 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 766760008120 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 766760008121 dimer interface [polypeptide binding]; other site 766760008122 motif 1; other site 766760008123 active site 766760008124 motif 2; other site 766760008125 motif 3; other site 766760008126 Recombination protein O N terminal; Region: RecO_N; pfam11967 766760008127 DNA repair protein RecO; Region: reco; TIGR00613 766760008128 Recombination protein O C terminal; Region: RecO_C; pfam02565 766760008129 YqzL-like protein; Region: YqzL; pfam14006 766760008130 GTPase Era; Reviewed; Region: era; PRK00089 766760008131 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 766760008132 G1 box; other site 766760008133 GTP/Mg2+ binding site [chemical binding]; other site 766760008134 Switch I region; other site 766760008135 G2 box; other site 766760008136 Switch II region; other site 766760008137 G3 box; other site 766760008138 G4 box; other site 766760008139 G5 box; other site 766760008140 KH domain; Region: KH_2; pfam07650 766760008141 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 766760008142 active site 766760008143 catalytic motif [active] 766760008144 Zn binding site [ion binding]; other site 766760008145 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 766760008146 metal-binding heat shock protein; Provisional; Region: PRK00016 766760008147 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 766760008148 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 766760008149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760008150 Zn2+ binding site [ion binding]; other site 766760008151 Mg2+ binding site [ion binding]; other site 766760008152 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 766760008153 PhoH-like protein; Region: PhoH; pfam02562 766760008154 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 766760008155 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 766760008156 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 766760008157 hypothetical protein; Provisional; Region: PRK13665 766760008158 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 766760008159 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 766760008160 dimer interface [polypeptide binding]; other site 766760008161 active site residues [active] 766760008162 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 766760008163 Yqey-like protein; Region: YqeY; pfam09424 766760008164 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 766760008165 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 766760008166 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 766760008167 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 766760008168 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 766760008169 intersubunit interface [polypeptide binding]; other site 766760008170 active site 766760008171 catalytic residue [active] 766760008172 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 766760008173 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 766760008174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760008175 FeS/SAM binding site; other site 766760008176 TRAM domain; Region: TRAM; cl01282 766760008177 RNA methyltransferase, RsmE family; Region: TIGR00046 766760008178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 766760008179 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 766760008180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008181 S-adenosylmethionine binding site [chemical binding]; other site 766760008182 chaperone protein DnaJ; Provisional; Region: PRK14280 766760008183 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 766760008184 HSP70 interaction site [polypeptide binding]; other site 766760008185 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 766760008186 substrate binding site [polypeptide binding]; other site 766760008187 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 766760008188 Zn binding sites [ion binding]; other site 766760008189 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 766760008190 dimer interface [polypeptide binding]; other site 766760008191 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 766760008192 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 766760008193 nucleotide binding site [chemical binding]; other site 766760008194 NEF interaction site [polypeptide binding]; other site 766760008195 SBD interface [polypeptide binding]; other site 766760008196 heat shock protein GrpE; Provisional; Region: PRK14140 766760008197 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 766760008198 dimer interface [polypeptide binding]; other site 766760008199 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 766760008200 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 766760008201 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 766760008202 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 766760008203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760008204 FeS/SAM binding site; other site 766760008205 HemN C-terminal domain; Region: HemN_C; pfam06969 766760008206 GTP-binding protein LepA; Provisional; Region: PRK05433 766760008207 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 766760008208 G1 box; other site 766760008209 putative GEF interaction site [polypeptide binding]; other site 766760008210 GTP/Mg2+ binding site [chemical binding]; other site 766760008211 Switch I region; other site 766760008212 G2 box; other site 766760008213 G3 box; other site 766760008214 Switch II region; other site 766760008215 G4 box; other site 766760008216 G5 box; other site 766760008217 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 766760008218 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 766760008219 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 766760008220 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 766760008221 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 766760008222 stage II sporulation protein P; Region: spore_II_P; TIGR02867 766760008223 germination protease; Provisional; Region: PRK02858 766760008224 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 766760008225 hypothetical protein; Provisional; Region: PRK07758 766760008226 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760008227 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760008228 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 766760008229 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 766760008230 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 766760008231 YqzM-like protein; Region: YqzM; pfam14141 766760008232 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 766760008233 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 766760008234 Competence protein; Region: Competence; pfam03772 766760008235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760008236 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 766760008237 catalytic motif [active] 766760008238 Zn binding site [ion binding]; other site 766760008239 SLBB domain; Region: SLBB; pfam10531 766760008240 comEA protein; Region: comE; TIGR01259 766760008241 Helix-hairpin-helix motif; Region: HHH; pfam00633 766760008242 late competence protein ComER; Validated; Region: PRK07680 766760008243 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 766760008244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008245 S-adenosylmethionine binding site [chemical binding]; other site 766760008246 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 766760008247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760008248 Zn2+ binding site [ion binding]; other site 766760008249 Mg2+ binding site [ion binding]; other site 766760008250 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 766760008251 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 766760008252 active site 766760008253 (T/H)XGH motif; other site 766760008254 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 766760008255 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 766760008256 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 766760008257 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 766760008258 shikimate binding site; other site 766760008259 NAD(P) binding site [chemical binding]; other site 766760008260 GTPase YqeH; Provisional; Region: PRK13796 766760008261 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 766760008262 GTP/Mg2+ binding site [chemical binding]; other site 766760008263 G4 box; other site 766760008264 G5 box; other site 766760008265 G1 box; other site 766760008266 Switch I region; other site 766760008267 G2 box; other site 766760008268 G3 box; other site 766760008269 Switch II region; other site 766760008270 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 766760008271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760008272 active site 766760008273 motif I; other site 766760008274 motif II; other site 766760008275 Sporulation inhibitor A; Region: Sda; pfam08970 766760008276 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 766760008277 active site 766760008278 catalytic triad [active] 766760008279 oxyanion hole [active] 766760008280 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 766760008281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760008282 Uncharacterized conserved protein [Function unknown]; Region: COG5609 766760008283 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 766760008284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 766760008285 catalytic loop [active] 766760008286 iron binding site [ion binding]; other site 766760008287 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 766760008288 4Fe-4S binding domain; Region: Fer4; pfam00037 766760008289 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 766760008290 [4Fe-4S] binding site [ion binding]; other site 766760008291 molybdopterin cofactor binding site; other site 766760008292 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 766760008293 molybdopterin cofactor binding site; other site 766760008294 Uncharacterized conserved protein [Function unknown]; Region: COG2427 766760008295 sporulation sigma factor SigK; Reviewed; Region: PRK05803 766760008296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760008297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760008298 DNA binding residues [nucleotide binding] 766760008299 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 766760008300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760008301 Coenzyme A binding pocket [chemical binding]; other site 766760008302 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 766760008303 DNA binding residues [nucleotide binding] 766760008304 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 766760008305 HTH domain; Region: HTH_11; pfam08279 766760008306 Mga helix-turn-helix domain; Region: Mga; pfam05043 766760008307 PRD domain; Region: PRD; pfam00874 766760008308 PRD domain; Region: PRD; pfam00874 766760008309 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 766760008310 active site 766760008311 P-loop; other site 766760008312 phosphorylation site [posttranslational modification] 766760008313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760008314 active site 766760008315 phosphorylation site [posttranslational modification] 766760008316 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 766760008317 dimerization domain swap beta strand [polypeptide binding]; other site 766760008318 regulatory protein interface [polypeptide binding]; other site 766760008319 active site 766760008320 regulatory phosphorylation site [posttranslational modification]; other site 766760008321 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 766760008322 beta-galactosidase; Region: BGL; TIGR03356 766760008323 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 766760008324 methionine cluster; other site 766760008325 active site 766760008326 phosphorylation site [posttranslational modification] 766760008327 metal binding site [ion binding]; metal-binding site 766760008328 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 766760008329 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 766760008330 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 766760008331 active site 766760008332 P-loop; other site 766760008333 phosphorylation site [posttranslational modification] 766760008334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760008335 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 766760008336 active site 766760008337 motif I; other site 766760008338 motif II; other site 766760008339 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 766760008340 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 766760008341 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 766760008342 NAD binding site [chemical binding]; other site 766760008343 sugar binding site [chemical binding]; other site 766760008344 divalent metal binding site [ion binding]; other site 766760008345 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760008346 dimer interface [polypeptide binding]; other site 766760008347 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 766760008348 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 766760008349 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 766760008350 putative active site [active] 766760008351 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 766760008352 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 766760008353 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 766760008354 DNA binding residues [nucleotide binding] 766760008355 drug binding residues [chemical binding]; other site 766760008356 dimer interface [polypeptide binding]; other site 766760008357 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 766760008358 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 766760008359 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 766760008360 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 766760008361 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 766760008362 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 766760008363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 766760008364 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 766760008365 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 766760008366 [4Fe-4S] binding site [ion binding]; other site 766760008367 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760008368 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760008369 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760008370 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 766760008371 molybdopterin cofactor binding site; other site 766760008372 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 766760008373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760008374 putative substrate translocation pore; other site 766760008375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760008376 PAS domain; Region: PAS_9; pfam13426 766760008377 putative active site [active] 766760008378 heme pocket [chemical binding]; other site 766760008379 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 766760008380 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 766760008381 heme-binding site [chemical binding]; other site 766760008382 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 766760008383 FAD binding pocket [chemical binding]; other site 766760008384 FAD binding motif [chemical binding]; other site 766760008385 phosphate binding motif [ion binding]; other site 766760008386 beta-alpha-beta structure motif; other site 766760008387 NAD binding pocket [chemical binding]; other site 766760008388 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 766760008389 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 766760008390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760008391 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 766760008392 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 766760008393 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 766760008394 Transposase; Region: DDE_Tnp_ISL3; pfam01610 766760008395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 766760008396 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 766760008397 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 766760008398 active site residue [active] 766760008399 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 766760008400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760008401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760008402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760008403 active site 766760008404 phosphorylation site [posttranslational modification] 766760008405 intermolecular recognition site; other site 766760008406 dimerization interface [polypeptide binding]; other site 766760008407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760008408 DNA binding residues [nucleotide binding] 766760008409 dimerization interface [polypeptide binding]; other site 766760008410 PAS domain S-box; Region: sensory_box; TIGR00229 766760008411 PAS domain; Region: PAS_8; pfam13188 766760008412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 766760008413 Histidine kinase; Region: HisKA_3; pfam07730 766760008414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760008415 ATP binding site [chemical binding]; other site 766760008416 Mg2+ binding site [ion binding]; other site 766760008417 G-X-G motif; other site 766760008418 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 766760008419 catalytic residues [active] 766760008420 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 766760008421 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 766760008422 CPxP motif; other site 766760008423 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 766760008424 active site residue [active] 766760008425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760008426 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 766760008427 CPxP motif; other site 766760008428 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 766760008429 active site residue [active] 766760008430 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 766760008431 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 766760008432 putative homodimer interface [polypeptide binding]; other site 766760008433 putative homotetramer interface [polypeptide binding]; other site 766760008434 putative allosteric switch controlling residues; other site 766760008435 putative metal binding site [ion binding]; other site 766760008436 putative homodimer-homodimer interface [polypeptide binding]; other site 766760008437 Methyltransferase domain; Region: Methyltransf_31; pfam13847 766760008438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008439 S-adenosylmethionine binding site [chemical binding]; other site 766760008440 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 766760008441 A new structural DNA glycosylase; Region: AlkD_like; cd06561 766760008442 active site 766760008443 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 766760008444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008445 S-adenosylmethionine binding site [chemical binding]; other site 766760008446 Tautomerase enzyme; Region: Tautomerase; pfam01361 766760008447 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 766760008448 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 766760008449 tetramer interface [polypeptide binding]; other site 766760008450 active site 766760008451 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 766760008452 active site 766760008453 dimer interface [polypeptide binding]; other site 766760008454 magnesium binding site [ion binding]; other site 766760008455 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760008456 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760008457 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 766760008458 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 766760008459 putative di-iron ligands [ion binding]; other site 766760008460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760008461 Histidine kinase; Region: HisKA_3; pfam07730 766760008462 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 766760008463 ATP binding site [chemical binding]; other site 766760008464 Mg2+ binding site [ion binding]; other site 766760008465 G-X-G motif; other site 766760008466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760008467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760008468 active site 766760008469 phosphorylation site [posttranslational modification] 766760008470 intermolecular recognition site; other site 766760008471 dimerization interface [polypeptide binding]; other site 766760008472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760008473 DNA binding residues [nucleotide binding] 766760008474 dimerization interface [polypeptide binding]; other site 766760008475 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 766760008476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760008477 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 766760008478 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 766760008479 substrate binding site [chemical binding]; other site 766760008480 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 766760008481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760008482 dimer interface [polypeptide binding]; other site 766760008483 conserved gate region; other site 766760008484 putative PBP binding loops; other site 766760008485 ABC-ATPase subunit interface; other site 766760008486 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 766760008487 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 766760008488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760008489 dimer interface [polypeptide binding]; other site 766760008490 conserved gate region; other site 766760008491 putative PBP binding loops; other site 766760008492 ABC-ATPase subunit interface; other site 766760008493 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760008494 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 766760008495 Walker A/P-loop; other site 766760008496 ATP binding site [chemical binding]; other site 766760008497 Q-loop/lid; other site 766760008498 ABC transporter signature motif; other site 766760008499 Walker B; other site 766760008500 D-loop; other site 766760008501 H-loop/switch region; other site 766760008502 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 766760008503 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 766760008504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 766760008505 Walker A/P-loop; other site 766760008506 ATP binding site [chemical binding]; other site 766760008507 Q-loop/lid; other site 766760008508 ABC transporter signature motif; other site 766760008509 Walker B; other site 766760008510 D-loop; other site 766760008511 H-loop/switch region; other site 766760008512 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 766760008513 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 766760008514 DNA binding residues [nucleotide binding] 766760008515 drug binding residues [chemical binding]; other site 766760008516 dimer interface [polypeptide binding]; other site 766760008517 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 766760008518 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 766760008519 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 766760008520 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 766760008521 Helix-turn-helix domain; Region: HTH_18; pfam12833 766760008522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760008523 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 766760008524 classical (c) SDRs; Region: SDR_c; cd05233 766760008525 NAD(P) binding site [chemical binding]; other site 766760008526 active site 766760008527 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 766760008528 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 766760008529 active site 766760008530 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 766760008531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 766760008532 substrate binding pocket [chemical binding]; other site 766760008533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760008534 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 766760008535 Cytochrome P450; Region: p450; cl12078 766760008536 hypothetical protein; Provisional; Region: PRK10621 766760008537 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 766760008538 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 766760008539 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 766760008540 inhibitor binding site; inhibition site 766760008541 active site 766760008542 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 766760008543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760008544 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 766760008545 classical (c) SDRs; Region: SDR_c; cd05233 766760008546 NAD(P) binding site [chemical binding]; other site 766760008547 active site 766760008548 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 766760008549 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 766760008550 substrate binding [chemical binding]; other site 766760008551 active site 766760008552 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 766760008553 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 766760008554 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 766760008555 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 766760008556 active site 766760008557 phosphorylation site [posttranslational modification] 766760008558 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 766760008559 active pocket/dimerization site; other site 766760008560 active site 766760008561 phosphorylation site [posttranslational modification] 766760008562 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 766760008563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760008564 ATP binding site [chemical binding]; other site 766760008565 Walker A motif; other site 766760008566 Walker B motif; other site 766760008567 arginine finger; other site 766760008568 Transcriptional antiterminator [Transcription]; Region: COG3933 766760008569 PRD domain; Region: PRD; pfam00874 766760008570 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 766760008571 active pocket/dimerization site; other site 766760008572 active site 766760008573 phosphorylation site [posttranslational modification] 766760008574 PRD domain; Region: PRD; pfam00874 766760008575 Chloramphenicol acetyltransferase; Region: CAT; cl02008 766760008576 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 766760008577 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 766760008578 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 766760008579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760008580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760008581 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 766760008582 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 766760008583 DNA binding site [nucleotide binding] 766760008584 active site 766760008585 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 766760008586 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 766760008587 Ligand Binding Site [chemical binding]; other site 766760008588 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 766760008589 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 766760008590 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 766760008591 Soluble P-type ATPase [General function prediction only]; Region: COG4087 766760008592 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 766760008593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 766760008594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 766760008595 active site 766760008596 catalytic tetrad [active] 766760008597 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 766760008598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760008599 putative substrate translocation pore; other site 766760008600 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760008601 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760008602 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 766760008603 active site pocket [active] 766760008604 oxyanion hole [active] 766760008605 catalytic triad [active] 766760008606 active site nucleophile [active] 766760008607 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 766760008608 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 766760008609 active site 766760008610 Cupin domain; Region: Cupin_2; cl17218 766760008611 Cupin domain; Region: Cupin_2; cl17218 766760008612 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760008613 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 766760008614 intersubunit interface [polypeptide binding]; other site 766760008615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760008616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760008617 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 766760008618 putative dimerization interface [polypeptide binding]; other site 766760008619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760008620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760008621 putative substrate translocation pore; other site 766760008622 YoqO-like protein; Region: YoqO; pfam14037 766760008623 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 766760008624 Cytochrome P450; Region: p450; pfam00067 766760008625 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 766760008626 Flavodoxin; Region: Flavodoxin_1; pfam00258 766760008627 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 766760008628 FAD binding pocket [chemical binding]; other site 766760008629 FAD binding motif [chemical binding]; other site 766760008630 catalytic residues [active] 766760008631 NAD binding pocket [chemical binding]; other site 766760008632 phosphate binding motif [ion binding]; other site 766760008633 beta-alpha-beta structure motif; other site 766760008634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760008635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760008636 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 766760008637 active site 766760008638 catalytic triad [active] 766760008639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008640 S-adenosylmethionine binding site [chemical binding]; other site 766760008641 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 766760008642 YrhC-like protein; Region: YrhC; pfam14143 766760008643 cystathionine beta-lyase; Provisional; Region: PRK07671 766760008644 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 766760008645 homodimer interface [polypeptide binding]; other site 766760008646 substrate-cofactor binding pocket; other site 766760008647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760008648 catalytic residue [active] 766760008649 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 766760008650 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 766760008651 dimer interface [polypeptide binding]; other site 766760008652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760008653 catalytic residue [active] 766760008654 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 766760008655 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 766760008656 Methyltransferase domain; Region: Methyltransf_31; pfam13847 766760008657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008658 S-adenosylmethionine binding site [chemical binding]; other site 766760008659 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 766760008660 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 766760008661 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 766760008662 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 766760008663 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 766760008664 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 766760008665 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 766760008666 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 766760008667 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 766760008668 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 766760008669 ATP-binding site [chemical binding]; other site 766760008670 Sugar specificity; other site 766760008671 Pyrimidine base specificity; other site 766760008672 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 766760008673 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 766760008674 Peptidase family U32; Region: Peptidase_U32; pfam01136 766760008675 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 766760008676 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 766760008677 Peptidase family U32; Region: Peptidase_U32; pfam01136 766760008678 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 766760008679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760008680 S-adenosylmethionine binding site [chemical binding]; other site 766760008681 YceG-like family; Region: YceG; pfam02618 766760008682 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 766760008683 dimerization interface [polypeptide binding]; other site 766760008684 hypothetical protein; Provisional; Region: PRK13678 766760008685 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 766760008686 hypothetical protein; Provisional; Region: PRK05473 766760008687 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 766760008688 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 766760008689 motif 1; other site 766760008690 active site 766760008691 motif 2; other site 766760008692 motif 3; other site 766760008693 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 766760008694 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 766760008695 Domain of unknown function DUF20; Region: UPF0118; pfam01594 766760008696 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 766760008697 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 766760008698 AAA domain; Region: AAA_30; pfam13604 766760008699 Family description; Region: UvrD_C_2; pfam13538 766760008700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760008701 binding surface 766760008702 TPR repeat; Region: TPR_11; pfam13414 766760008703 TPR motif; other site 766760008704 TPR repeat; Region: TPR_11; pfam13414 766760008705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760008706 binding surface 766760008707 TPR motif; other site 766760008708 TPR repeat; Region: TPR_11; pfam13414 766760008709 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 766760008710 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 766760008711 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 766760008712 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 766760008713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760008714 catalytic residue [active] 766760008715 Predicted transcriptional regulator [Transcription]; Region: COG1959 766760008716 Transcriptional regulator; Region: Rrf2; pfam02082 766760008717 recombination factor protein RarA; Reviewed; Region: PRK13342 766760008718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760008719 Walker A motif; other site 766760008720 ATP binding site [chemical binding]; other site 766760008721 Walker B motif; other site 766760008722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 766760008723 arginine finger; other site 766760008724 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 766760008725 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 766760008726 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 766760008727 putative ATP binding site [chemical binding]; other site 766760008728 putative substrate interface [chemical binding]; other site 766760008729 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 766760008730 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 766760008731 dimer interface [polypeptide binding]; other site 766760008732 anticodon binding site; other site 766760008733 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 766760008734 homodimer interface [polypeptide binding]; other site 766760008735 motif 1; other site 766760008736 active site 766760008737 motif 2; other site 766760008738 GAD domain; Region: GAD; pfam02938 766760008739 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 766760008740 motif 3; other site 766760008741 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 766760008742 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 766760008743 dimer interface [polypeptide binding]; other site 766760008744 motif 1; other site 766760008745 active site 766760008746 motif 2; other site 766760008747 motif 3; other site 766760008748 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 766760008749 anticodon binding site; other site 766760008750 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 766760008751 Bacterial SH3 domain; Region: SH3_3; pfam08239 766760008752 Bacterial SH3 domain; Region: SH3_3; pfam08239 766760008753 Bacterial SH3 domain; Region: SH3_3; pfam08239 766760008754 Bacterial SH3 domain homologues; Region: SH3b; smart00287 766760008755 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 766760008756 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 766760008757 active site 766760008758 metal binding site [ion binding]; metal-binding site 766760008759 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 766760008760 putative active site [active] 766760008761 dimerization interface [polypeptide binding]; other site 766760008762 putative tRNAtyr binding site [nucleotide binding]; other site 766760008763 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 766760008764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760008765 Zn2+ binding site [ion binding]; other site 766760008766 Mg2+ binding site [ion binding]; other site 766760008767 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 766760008768 synthetase active site [active] 766760008769 NTP binding site [chemical binding]; other site 766760008770 metal binding site [ion binding]; metal-binding site 766760008771 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 766760008772 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 766760008773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760008774 active site 766760008775 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 766760008776 DHH family; Region: DHH; pfam01368 766760008777 DHHA1 domain; Region: DHHA1; pfam02272 766760008778 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 766760008779 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 766760008780 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 766760008781 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 766760008782 Protein export membrane protein; Region: SecD_SecF; pfam02355 766760008783 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 766760008784 stage V sporulation protein B; Region: spore_V_B; TIGR02900 766760008785 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 766760008786 Predicted membrane protein [Function unknown]; Region: COG2323 766760008787 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 766760008788 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 766760008789 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 766760008790 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 766760008791 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 766760008792 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 766760008793 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 766760008794 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 766760008795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760008796 Walker A motif; other site 766760008797 ATP binding site [chemical binding]; other site 766760008798 Walker B motif; other site 766760008799 arginine finger; other site 766760008800 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 766760008801 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 766760008802 RuvA N terminal domain; Region: RuvA_N; pfam01330 766760008803 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 766760008804 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 766760008805 BofC C-terminal domain; Region: BofC_C; pfam08955 766760008806 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 766760008807 active site 766760008808 substrate binding site [chemical binding]; other site 766760008809 ATP binding site [chemical binding]; other site 766760008810 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 766760008811 DinB family; Region: DinB; cl17821 766760008812 DinB superfamily; Region: DinB_2; pfam12867 766760008813 Protein of unknown function (DUF867); Region: DUF867; pfam05908 766760008814 hypothetical protein; Validated; Region: PRK00110 766760008815 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 766760008816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760008817 quinolinate synthetase; Provisional; Region: PRK09375 766760008818 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 766760008819 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 766760008820 dimerization interface [polypeptide binding]; other site 766760008821 active site 766760008822 L-aspartate oxidase; Provisional; Region: PRK08071 766760008823 L-aspartate oxidase; Provisional; Region: PRK06175 766760008824 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 766760008825 cysteine desulfurase; Provisional; Region: PRK02948 766760008826 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 766760008827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760008828 catalytic residue [active] 766760008829 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 766760008830 HTH domain; Region: HTH_11; pfam08279 766760008831 3H domain; Region: 3H; pfam02829 766760008832 prephenate dehydratase; Provisional; Region: PRK11898 766760008833 Prephenate dehydratase; Region: PDT; pfam00800 766760008834 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 766760008835 putative L-Phe binding site [chemical binding]; other site 766760008836 hypothetical protein; Provisional; Region: PRK04435 766760008837 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 766760008838 GTPase CgtA; Reviewed; Region: obgE; PRK12297 766760008839 GTP1/OBG; Region: GTP1_OBG; pfam01018 766760008840 Obg GTPase; Region: Obg; cd01898 766760008841 G1 box; other site 766760008842 GTP/Mg2+ binding site [chemical binding]; other site 766760008843 Switch I region; other site 766760008844 G2 box; other site 766760008845 G3 box; other site 766760008846 Switch II region; other site 766760008847 G4 box; other site 766760008848 G5 box; other site 766760008849 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 766760008850 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 766760008851 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 766760008852 hypothetical protein; Provisional; Region: PRK14553 766760008853 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 766760008854 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 766760008855 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 766760008856 Peptidase family M50; Region: Peptidase_M50; pfam02163 766760008857 active site 766760008858 putative substrate binding region [chemical binding]; other site 766760008859 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 766760008860 Peptidase family M23; Region: Peptidase_M23; pfam01551 766760008861 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 766760008862 putative hydrophobic ligand binding site [chemical binding]; other site 766760008863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760008864 putative DNA binding site [nucleotide binding]; other site 766760008865 putative Zn2+ binding site [ion binding]; other site 766760008866 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 766760008867 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 766760008868 Switch I; other site 766760008869 Switch II; other site 766760008870 septum formation inhibitor; Reviewed; Region: minC; PRK00513 766760008871 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 766760008872 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 766760008873 rod shape-determining protein MreC; Provisional; Region: PRK13922 766760008874 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 766760008875 rod shape-determining protein MreC; Region: MreC; pfam04085 766760008876 rod shape-determining protein MreB; Provisional; Region: PRK13927 766760008877 MreB and similar proteins; Region: MreB_like; cd10225 766760008878 nucleotide binding site [chemical binding]; other site 766760008879 Mg binding site [ion binding]; other site 766760008880 putative protofilament interaction site [polypeptide binding]; other site 766760008881 RodZ interaction site [polypeptide binding]; other site 766760008882 hypothetical protein; Reviewed; Region: PRK00024 766760008883 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 766760008884 MPN+ (JAMM) motif; other site 766760008885 Zinc-binding site [ion binding]; other site 766760008886 Maf-like protein; Region: Maf; pfam02545 766760008887 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 766760008888 active site 766760008889 dimer interface [polypeptide binding]; other site 766760008890 Sporulation related domain; Region: SPOR; pfam05036 766760008891 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 766760008892 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 766760008893 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 766760008894 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 766760008895 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 766760008896 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 766760008897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 766760008898 active site 766760008899 HIGH motif; other site 766760008900 nucleotide binding site [chemical binding]; other site 766760008901 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 766760008902 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 766760008903 active site 766760008904 KMSKS motif; other site 766760008905 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 766760008906 tRNA binding surface [nucleotide binding]; other site 766760008907 anticodon binding site; other site 766760008908 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 766760008909 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 766760008910 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 766760008911 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 766760008912 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 766760008913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 766760008914 inhibitor-cofactor binding pocket; inhibition site 766760008915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760008916 catalytic residue [active] 766760008917 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 766760008918 dimer interface [polypeptide binding]; other site 766760008919 active site 766760008920 Schiff base residues; other site 766760008921 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 766760008922 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 766760008923 active site 766760008924 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 766760008925 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 766760008926 domain interfaces; other site 766760008927 active site 766760008928 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 766760008929 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 766760008930 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 766760008931 tRNA; other site 766760008932 putative tRNA binding site [nucleotide binding]; other site 766760008933 putative NADP binding site [chemical binding]; other site 766760008934 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 766760008935 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 766760008936 G1 box; other site 766760008937 GTP/Mg2+ binding site [chemical binding]; other site 766760008938 Switch I region; other site 766760008939 G2 box; other site 766760008940 G3 box; other site 766760008941 Switch II region; other site 766760008942 G4 box; other site 766760008943 G5 box; other site 766760008944 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 766760008945 Found in ATP-dependent protease La (LON); Region: LON; smart00464 766760008946 Found in ATP-dependent protease La (LON); Region: LON; smart00464 766760008947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760008948 Walker A motif; other site 766760008949 ATP binding site [chemical binding]; other site 766760008950 Walker B motif; other site 766760008951 arginine finger; other site 766760008952 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 766760008953 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 766760008954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760008955 Walker A motif; other site 766760008956 ATP binding site [chemical binding]; other site 766760008957 Walker B motif; other site 766760008958 arginine finger; other site 766760008959 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 766760008960 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 766760008961 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 766760008962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760008963 Walker A motif; other site 766760008964 ATP binding site [chemical binding]; other site 766760008965 Walker B motif; other site 766760008966 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 766760008967 trigger factor; Provisional; Region: tig; PRK01490 766760008968 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 766760008969 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 766760008970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760008971 binding surface 766760008972 Tetratricopeptide repeat; Region: TPR_16; pfam13432 766760008973 TPR motif; other site 766760008974 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 766760008975 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 766760008976 substrate binding site [chemical binding]; other site 766760008977 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 766760008978 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 766760008979 substrate binding site [chemical binding]; other site 766760008980 ligand binding site [chemical binding]; other site 766760008981 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 766760008982 tartrate dehydrogenase; Region: TTC; TIGR02089 766760008983 2-isopropylmalate synthase; Validated; Region: PRK00915 766760008984 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 766760008985 active site 766760008986 catalytic residues [active] 766760008987 metal binding site [ion binding]; metal-binding site 766760008988 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 766760008989 ketol-acid reductoisomerase; Provisional; Region: PRK05479 766760008990 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 766760008991 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 766760008992 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 766760008993 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 766760008994 putative valine binding site [chemical binding]; other site 766760008995 dimer interface [polypeptide binding]; other site 766760008996 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 766760008997 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 766760008998 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 766760008999 PYR/PP interface [polypeptide binding]; other site 766760009000 dimer interface [polypeptide binding]; other site 766760009001 TPP binding site [chemical binding]; other site 766760009002 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 766760009003 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 766760009004 TPP-binding site [chemical binding]; other site 766760009005 dimer interface [polypeptide binding]; other site 766760009006 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 766760009007 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 766760009008 homodimer interface [polypeptide binding]; other site 766760009009 substrate-cofactor binding pocket; other site 766760009010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760009011 catalytic residue [active] 766760009012 glutamate dehydrogenase; Provisional; Region: PRK09414 766760009013 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 766760009014 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 766760009015 NAD(P) binding site [chemical binding]; other site 766760009016 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 766760009017 active site 766760009018 metal binding site [ion binding]; metal-binding site 766760009019 homotetramer interface [polypeptide binding]; other site 766760009020 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 766760009021 active site 766760009022 dimerization interface [polypeptide binding]; other site 766760009023 ribonuclease PH; Reviewed; Region: rph; PRK00173 766760009024 Ribonuclease PH; Region: RNase_PH_bact; cd11362 766760009025 hexamer interface [polypeptide binding]; other site 766760009026 active site 766760009027 Sporulation and spore germination; Region: Germane; pfam10646 766760009028 Spore germination protein [General function prediction only]; Region: COG5401 766760009029 Sporulation and spore germination; Region: Germane; pfam10646 766760009030 glutamate racemase; Provisional; Region: PRK00865 766760009031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760009032 MarR family; Region: MarR; pfam01047 766760009033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760009034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760009035 DNA binding residues [nucleotide binding] 766760009036 dimerization interface [polypeptide binding]; other site 766760009037 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 766760009038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760009039 NAD(P) binding site [chemical binding]; other site 766760009040 active site 766760009041 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 766760009042 active site 766760009043 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 766760009044 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 766760009045 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 766760009046 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 766760009047 L-aspartate oxidase; Provisional; Region: PRK06175 766760009048 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 766760009049 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 766760009050 putative Iron-sulfur protein interface [polypeptide binding]; other site 766760009051 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 766760009052 proximal heme binding site [chemical binding]; other site 766760009053 distal heme binding site [chemical binding]; other site 766760009054 putative dimer interface [polypeptide binding]; other site 766760009055 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 766760009056 aspartate kinase; Reviewed; Region: PRK06635 766760009057 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 766760009058 putative nucleotide binding site [chemical binding]; other site 766760009059 putative catalytic residues [active] 766760009060 putative Mg ion binding site [ion binding]; other site 766760009061 putative aspartate binding site [chemical binding]; other site 766760009062 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 766760009063 putative allosteric regulatory site; other site 766760009064 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 766760009065 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 766760009066 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 766760009067 GIY-YIG motif/motif A; other site 766760009068 active site 766760009069 catalytic site [active] 766760009070 putative DNA binding site [nucleotide binding]; other site 766760009071 metal binding site [ion binding]; metal-binding site 766760009072 UvrB/uvrC motif; Region: UVR; pfam02151 766760009073 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 766760009074 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 766760009075 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 766760009076 catalytic residues [active] 766760009077 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 766760009078 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 766760009079 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 766760009080 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 766760009081 Ligand binding site [chemical binding]; other site 766760009082 Electron transfer flavoprotein domain; Region: ETF; pfam01012 766760009083 enoyl-CoA hydratase; Provisional; Region: PRK07658 766760009084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760009085 substrate binding site [chemical binding]; other site 766760009086 oxyanion hole (OAH) forming residues; other site 766760009087 trimer interface [polypeptide binding]; other site 766760009088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760009089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760009090 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 766760009091 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 766760009092 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 766760009093 acyl-activating enzyme (AAE) consensus motif; other site 766760009094 putative AMP binding site [chemical binding]; other site 766760009095 putative active site [active] 766760009096 putative CoA binding site [chemical binding]; other site 766760009097 Predicted membrane protein [Function unknown]; Region: COG3766 766760009098 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 766760009099 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 766760009100 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 766760009101 MutS domain III; Region: MutS_III; pfam05192 766760009102 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 766760009103 Walker A/P-loop; other site 766760009104 ATP binding site [chemical binding]; other site 766760009105 Q-loop/lid; other site 766760009106 ABC transporter signature motif; other site 766760009107 Walker B; other site 766760009108 D-loop; other site 766760009109 H-loop/switch region; other site 766760009110 Smr domain; Region: Smr; pfam01713 766760009111 hypothetical protein; Provisional; Region: PRK08609 766760009112 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 766760009113 active site 766760009114 primer binding site [nucleotide binding]; other site 766760009115 NTP binding site [chemical binding]; other site 766760009116 metal binding triad [ion binding]; metal-binding site 766760009117 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 766760009118 active site 766760009119 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 766760009120 Colicin V production protein; Region: Colicin_V; pfam02674 766760009121 cell division protein ZapA; Provisional; Region: PRK14126 766760009122 ribonuclease HIII; Provisional; Region: PRK00996 766760009123 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 766760009124 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 766760009125 RNA/DNA hybrid binding site [nucleotide binding]; other site 766760009126 active site 766760009127 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 766760009128 active site 766760009129 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 766760009130 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 766760009131 putative tRNA-binding site [nucleotide binding]; other site 766760009132 B3/4 domain; Region: B3_4; pfam03483 766760009133 tRNA synthetase B5 domain; Region: B5; smart00874 766760009134 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 766760009135 dimer interface [polypeptide binding]; other site 766760009136 motif 1; other site 766760009137 motif 3; other site 766760009138 motif 2; other site 766760009139 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 766760009140 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 766760009141 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 766760009142 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 766760009143 dimer interface [polypeptide binding]; other site 766760009144 motif 1; other site 766760009145 active site 766760009146 motif 2; other site 766760009147 motif 3; other site 766760009148 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 766760009149 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 766760009150 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 766760009151 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 766760009152 Carbon starvation protein CstA; Region: CstA; pfam02554 766760009153 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 766760009154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760009155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760009156 Uncharacterized conserved protein [Function unknown]; Region: COG3402 766760009157 Predicted membrane protein [Function unknown]; Region: COG3428 766760009158 Bacterial PH domain; Region: DUF304; pfam03703 766760009159 Bacterial PH domain; Region: DUF304; pfam03703 766760009160 Bacterial PH domain; Region: DUF304; pfam03703 766760009161 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 766760009162 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 766760009163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760009164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760009165 dimer interface [polypeptide binding]; other site 766760009166 conserved gate region; other site 766760009167 putative PBP binding loops; other site 766760009168 ABC-ATPase subunit interface; other site 766760009169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760009170 dimer interface [polypeptide binding]; other site 766760009171 conserved gate region; other site 766760009172 putative PBP binding loops; other site 766760009173 ABC-ATPase subunit interface; other site 766760009174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760009175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760009176 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 766760009177 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 766760009178 active site 766760009179 metal binding site [ion binding]; metal-binding site 766760009180 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 766760009181 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 766760009182 intersubunit interface [polypeptide binding]; other site 766760009183 active site 766760009184 Zn2+ binding site [ion binding]; other site 766760009185 ribulokinase; Provisional; Region: PRK04123 766760009186 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 766760009187 active site 766760009188 MgATP binding site [chemical binding]; other site 766760009189 N- and C-terminal domain interface [polypeptide binding]; other site 766760009190 carbohydrate binding site [chemical binding]; other site 766760009191 homodimer interface [polypeptide binding]; other site 766760009192 L-arabinose isomerase; Provisional; Region: PRK02929 766760009193 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 766760009194 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 766760009195 trimer interface [polypeptide binding]; other site 766760009196 putative substrate binding site [chemical binding]; other site 766760009197 putative metal binding site [ion binding]; other site 766760009198 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 766760009199 substrate binding site [chemical binding]; other site 766760009200 active site 766760009201 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 766760009202 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 766760009203 oligomer interface [polypeptide binding]; other site 766760009204 active site 766760009205 metal binding site [ion binding]; metal-binding site 766760009206 Predicted membrane protein [Function unknown]; Region: COG3326 766760009207 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 766760009208 23S rRNA binding site [nucleotide binding]; other site 766760009209 L21 binding site [polypeptide binding]; other site 766760009210 L13 binding site [polypeptide binding]; other site 766760009211 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 766760009212 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 766760009213 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 766760009214 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 766760009215 antiholin-like protein LrgB; Provisional; Region: PRK04288 766760009216 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 766760009217 PhoD-like phosphatase; Region: PhoD; pfam09423 766760009218 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 766760009219 putative active site [active] 766760009220 putative metal binding site [ion binding]; other site 766760009221 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 766760009222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760009223 active site 766760009224 phosphorylation site [posttranslational modification] 766760009225 intermolecular recognition site; other site 766760009226 dimerization interface [polypeptide binding]; other site 766760009227 LytTr DNA-binding domain; Region: LytTR; pfam04397 766760009228 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 766760009229 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 766760009230 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 766760009231 Histidine kinase; Region: His_kinase; pfam06580 766760009232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760009233 ATP binding site [chemical binding]; other site 766760009234 Mg2+ binding site [ion binding]; other site 766760009235 G-X-G motif; other site 766760009236 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 766760009237 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 766760009238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760009239 motif II; other site 766760009240 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 766760009241 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 766760009242 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 766760009243 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 766760009244 active site 766760009245 dimer interface [polypeptide binding]; other site 766760009246 motif 1; other site 766760009247 motif 2; other site 766760009248 motif 3; other site 766760009249 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 766760009250 anticodon binding site; other site 766760009251 YtxC-like family; Region: YtxC; pfam08812 766760009252 Uncharacterized conserved protein [Function unknown]; Region: COG0398 766760009253 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 766760009254 primosomal protein DnaI; Reviewed; Region: PRK08939 766760009255 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 766760009256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760009257 Walker A motif; other site 766760009258 ATP binding site [chemical binding]; other site 766760009259 Walker B motif; other site 766760009260 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 766760009261 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 766760009262 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 766760009263 ATP cone domain; Region: ATP-cone; pfam03477 766760009264 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 766760009265 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 766760009266 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 766760009267 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 766760009268 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 766760009269 Pectate lyase; Region: Pec_lyase_C; cl01593 766760009270 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 766760009271 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 766760009272 CoA-binding site [chemical binding]; other site 766760009273 ATP-binding [chemical binding]; other site 766760009274 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 766760009275 Domain of unknown function DUF; Region: DUF204; pfam02659 766760009276 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 766760009277 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 766760009278 DNA binding site [nucleotide binding] 766760009279 catalytic residue [active] 766760009280 H2TH interface [polypeptide binding]; other site 766760009281 putative catalytic residues [active] 766760009282 turnover-facilitating residue; other site 766760009283 intercalation triad [nucleotide binding]; other site 766760009284 8OG recognition residue [nucleotide binding]; other site 766760009285 putative reading head residues; other site 766760009286 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 766760009287 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 766760009288 DNA polymerase I; Provisional; Region: PRK05755 766760009289 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 766760009290 active site 766760009291 metal binding site 1 [ion binding]; metal-binding site 766760009292 putative 5' ssDNA interaction site; other site 766760009293 metal binding site 3; metal-binding site 766760009294 metal binding site 2 [ion binding]; metal-binding site 766760009295 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 766760009296 putative DNA binding site [nucleotide binding]; other site 766760009297 putative metal binding site [ion binding]; other site 766760009298 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 766760009299 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 766760009300 active site 766760009301 DNA binding site [nucleotide binding] 766760009302 catalytic site [active] 766760009303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 766760009304 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 766760009305 PAS domain; Region: PAS; smart00091 766760009306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760009307 dimer interface [polypeptide binding]; other site 766760009308 phosphorylation site [posttranslational modification] 766760009309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760009310 ATP binding site [chemical binding]; other site 766760009311 Mg2+ binding site [ion binding]; other site 766760009312 G-X-G motif; other site 766760009313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760009314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760009315 active site 766760009316 phosphorylation site [posttranslational modification] 766760009317 intermolecular recognition site; other site 766760009318 dimerization interface [polypeptide binding]; other site 766760009319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760009320 DNA binding site [nucleotide binding] 766760009321 malate dehydrogenase; Reviewed; Region: PRK06223 766760009322 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 766760009323 NAD(P) binding site [chemical binding]; other site 766760009324 dimer interface [polypeptide binding]; other site 766760009325 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760009326 substrate binding site [chemical binding]; other site 766760009327 isocitrate dehydrogenase; Reviewed; Region: PRK07006 766760009328 isocitrate dehydrogenase; Validated; Region: PRK07362 766760009329 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 766760009330 dimer interface [polypeptide binding]; other site 766760009331 Citrate synthase; Region: Citrate_synt; pfam00285 766760009332 active site 766760009333 citrylCoA binding site [chemical binding]; other site 766760009334 oxalacetate/citrate binding site [chemical binding]; other site 766760009335 coenzyme A binding site [chemical binding]; other site 766760009336 catalytic triad [active] 766760009337 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 766760009338 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 766760009339 active site 766760009340 active site 766760009341 catalytic residues [active] 766760009342 Protein of unknown function (DUF441); Region: DUF441; pfam04284 766760009343 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 766760009344 Domain of unknown function DUF20; Region: UPF0118; pfam01594 766760009345 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 766760009346 pyruvate kinase; Provisional; Region: PRK06354 766760009347 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 766760009348 domain interfaces; other site 766760009349 active site 766760009350 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 766760009351 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 766760009352 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 766760009353 active site 766760009354 ADP/pyrophosphate binding site [chemical binding]; other site 766760009355 dimerization interface [polypeptide binding]; other site 766760009356 allosteric effector site; other site 766760009357 fructose-1,6-bisphosphate binding site; other site 766760009358 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 766760009359 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 766760009360 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 766760009361 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 766760009362 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 766760009363 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 766760009364 Malic enzyme, N-terminal domain; Region: malic; pfam00390 766760009365 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 766760009366 putative NAD(P) binding site [chemical binding]; other site 766760009367 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 766760009368 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 766760009369 active site 766760009370 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 766760009371 generic binding surface I; other site 766760009372 generic binding surface II; other site 766760009373 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 766760009374 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 766760009375 DHH family; Region: DHH; pfam01368 766760009376 DHHA1 domain; Region: DHHA1; pfam02272 766760009377 YtpI-like protein; Region: YtpI; pfam14007 766760009378 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 766760009379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760009380 DNA-binding site [nucleotide binding]; DNA binding site 766760009381 DRTGG domain; Region: DRTGG; pfam07085 766760009382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 766760009383 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 766760009384 active site 2 [active] 766760009385 active site 1 [active] 766760009386 Predicted transcriptional regulators [Transcription]; Region: COG1695 766760009387 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 766760009388 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 766760009389 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 766760009390 metal-dependent hydrolase; Provisional; Region: PRK00685 766760009391 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 766760009392 classical (c) SDRs; Region: SDR_c; cd05233 766760009393 NAD(P) binding site [chemical binding]; other site 766760009394 active site 766760009395 argininosuccinate lyase; Provisional; Region: PRK00855 766760009396 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 766760009397 active sites [active] 766760009398 tetramer interface [polypeptide binding]; other site 766760009399 argininosuccinate synthase; Provisional; Region: PRK13820 766760009400 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 766760009401 ANP binding site [chemical binding]; other site 766760009402 Substrate Binding Site II [chemical binding]; other site 766760009403 Substrate Binding Site I [chemical binding]; other site 766760009404 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 766760009405 MPT binding site; other site 766760009406 trimer interface [polypeptide binding]; other site 766760009407 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 766760009408 propionate/acetate kinase; Provisional; Region: PRK12379 766760009409 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 766760009410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760009411 S-adenosylmethionine binding site [chemical binding]; other site 766760009412 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 766760009413 dimer interface [polypeptide binding]; other site 766760009414 catalytic triad [active] 766760009415 peroxidatic and resolving cysteines [active] 766760009416 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 766760009417 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 766760009418 Predicted membrane protein/domain [Function unknown]; Region: COG1714 766760009419 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 766760009420 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 766760009421 tandem repeat interface [polypeptide binding]; other site 766760009422 oligomer interface [polypeptide binding]; other site 766760009423 active site residues [active] 766760009424 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 766760009425 ATP-NAD kinase; Region: NAD_kinase; pfam01513 766760009426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760009427 MarR family; Region: MarR; pfam01047 766760009428 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 766760009429 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 766760009430 active site 766760009431 acyl-activating enzyme (AAE) consensus motif; other site 766760009432 putative CoA binding site [chemical binding]; other site 766760009433 AMP binding site [chemical binding]; other site 766760009434 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 766760009435 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 766760009436 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 766760009437 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 766760009438 Ligand Binding Site [chemical binding]; other site 766760009439 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 766760009440 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 766760009441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760009442 catalytic residue [active] 766760009443 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 766760009444 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 766760009445 histidinol-phosphatase; Reviewed; Region: PRK08123 766760009446 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 766760009447 active site 766760009448 dimer interface [polypeptide binding]; other site 766760009449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760009450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760009451 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 766760009452 GAF domain; Region: GAF_2; pfam13185 766760009453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 766760009454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 766760009455 metal binding site [ion binding]; metal-binding site 766760009456 active site 766760009457 I-site; other site 766760009458 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 766760009459 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 766760009460 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760009461 RNA binding surface [nucleotide binding]; other site 766760009462 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 766760009463 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 766760009464 active site 766760009465 HIGH motif; other site 766760009466 dimer interface [polypeptide binding]; other site 766760009467 KMSKS motif; other site 766760009468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760009469 RNA binding surface [nucleotide binding]; other site 766760009470 acetyl-CoA synthetase; Provisional; Region: PRK04319 766760009471 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 766760009472 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 766760009473 active site 766760009474 acyl-activating enzyme (AAE) consensus motif; other site 766760009475 putative CoA binding site [chemical binding]; other site 766760009476 AMP binding site [chemical binding]; other site 766760009477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760009478 FOG: CBS domain [General function prediction only]; Region: COG0517 766760009479 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 766760009480 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 766760009481 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 766760009482 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 766760009483 active site 766760009484 Zn binding site [ion binding]; other site 766760009485 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 766760009486 flagellar motor protein MotS; Reviewed; Region: PRK06925 766760009487 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 766760009488 ligand binding site [chemical binding]; other site 766760009489 flagellar motor protein MotP; Reviewed; Region: PRK06926 766760009490 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 766760009491 catabolite control protein A; Region: ccpA; TIGR01481 766760009492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760009493 DNA binding site [nucleotide binding] 766760009494 domain linker motif; other site 766760009495 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 766760009496 dimerization interface [polypeptide binding]; other site 766760009497 effector binding site; other site 766760009498 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 766760009499 Chorismate mutase type II; Region: CM_2; cl00693 766760009500 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 766760009501 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 766760009502 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 766760009503 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 766760009504 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 766760009505 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 766760009506 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 766760009507 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 766760009508 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 766760009509 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 766760009510 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760009511 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 766760009512 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 766760009513 putative tRNA-binding site [nucleotide binding]; other site 766760009514 hypothetical protein; Provisional; Region: PRK13668 766760009515 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 766760009516 catalytic residues [active] 766760009517 YtoQ family protein; Region: YtoQ_fam; TIGR03646 766760009518 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 766760009519 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 766760009520 oligomer interface [polypeptide binding]; other site 766760009521 active site 766760009522 metal binding site [ion binding]; metal-binding site 766760009523 Predicted small secreted protein [Function unknown]; Region: COG5584 766760009524 malate dehydrogenase; Provisional; Region: PRK13529 766760009525 Malic enzyme, N-terminal domain; Region: malic; pfam00390 766760009526 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 766760009527 NAD(P) binding site [chemical binding]; other site 766760009528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 766760009529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760009530 S-adenosylmethionine binding site [chemical binding]; other site 766760009531 YtzH-like protein; Region: YtzH; pfam14165 766760009532 Phosphotransferase enzyme family; Region: APH; pfam01636 766760009533 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 766760009534 active site 766760009535 substrate binding site [chemical binding]; other site 766760009536 ATP binding site [chemical binding]; other site 766760009537 pullulanase, type I; Region: pulA_typeI; TIGR02104 766760009538 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 766760009539 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 766760009540 Ca binding site [ion binding]; other site 766760009541 active site 766760009542 catalytic site [active] 766760009543 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 766760009544 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 766760009545 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 766760009546 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 766760009547 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 766760009548 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 766760009549 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 766760009550 dimer interface [polypeptide binding]; other site 766760009551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760009552 catalytic residue [active] 766760009553 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 766760009554 dipeptidase PepV; Reviewed; Region: PRK07318 766760009555 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 766760009556 active site 766760009557 metal binding site [ion binding]; metal-binding site 766760009558 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 766760009559 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 766760009560 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 766760009561 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760009562 Walker A/P-loop; other site 766760009563 ATP binding site [chemical binding]; other site 766760009564 Q-loop/lid; other site 766760009565 ABC transporter signature motif; other site 766760009566 Walker B; other site 766760009567 D-loop; other site 766760009568 H-loop/switch region; other site 766760009569 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 766760009570 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 766760009571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 766760009572 RNA binding surface [nucleotide binding]; other site 766760009573 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 766760009574 active site 766760009575 uracil binding [chemical binding]; other site 766760009576 stage V sporulation protein B; Region: spore_V_B; TIGR02900 766760009577 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 766760009578 HI0933-like protein; Region: HI0933_like; pfam03486 766760009579 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 766760009580 BCCT family transporter; Region: BCCT; pfam02028 766760009581 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 766760009582 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 766760009583 active site residue [active] 766760009584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760009585 TPR motif; other site 766760009586 binding surface 766760009587 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760009588 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 766760009589 Predicted integral membrane protein [Function unknown]; Region: COG5578 766760009590 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760009591 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760009592 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 766760009593 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 766760009594 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 766760009595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 766760009596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760009597 dimer interface [polypeptide binding]; other site 766760009598 putative PBP binding loops; other site 766760009599 ABC-ATPase subunit interface; other site 766760009600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760009601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760009602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760009603 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760009604 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760009605 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760009606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760009607 dimer interface [polypeptide binding]; other site 766760009608 conserved gate region; other site 766760009609 putative PBP binding loops; other site 766760009610 ABC-ATPase subunit interface; other site 766760009611 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 766760009612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760009613 NAD(P) binding site [chemical binding]; other site 766760009614 active site 766760009615 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 766760009616 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 766760009617 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760009618 putative transporter; Provisional; Region: PRK11021 766760009619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760009620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760009621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760009622 dimerization interface [polypeptide binding]; other site 766760009623 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760009624 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 766760009625 active site 766760009626 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 766760009627 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 766760009628 HIGH motif; other site 766760009629 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 766760009630 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 766760009631 active site 766760009632 KMSKS motif; other site 766760009633 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 766760009634 tRNA binding surface [nucleotide binding]; other site 766760009635 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 766760009636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760009637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760009638 putative substrate translocation pore; other site 766760009639 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 766760009640 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 766760009641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 766760009642 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 766760009643 FtsX-like permease family; Region: FtsX; pfam02687 766760009644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760009645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760009646 Walker A/P-loop; other site 766760009647 ATP binding site [chemical binding]; other site 766760009648 Q-loop/lid; other site 766760009649 ABC transporter signature motif; other site 766760009650 Walker B; other site 766760009651 D-loop; other site 766760009652 H-loop/switch region; other site 766760009653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760009654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760009655 Walker A/P-loop; other site 766760009656 ATP binding site [chemical binding]; other site 766760009657 Q-loop/lid; other site 766760009658 ABC transporter signature motif; other site 766760009659 Walker B; other site 766760009660 D-loop; other site 766760009661 H-loop/switch region; other site 766760009662 Predicted transcriptional regulators [Transcription]; Region: COG1725 766760009663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760009664 DNA-binding site [nucleotide binding]; DNA binding site 766760009665 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 766760009666 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 766760009667 Methyltransferase domain; Region: Methyltransf_31; pfam13847 766760009668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760009669 S-adenosylmethionine binding site [chemical binding]; other site 766760009670 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 766760009671 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 766760009672 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760009673 Serine hydrolase; Region: Ser_hydrolase; cl17834 766760009674 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 766760009675 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 766760009676 trimer interface [polypeptide binding]; other site 766760009677 putative metal binding site [ion binding]; other site 766760009678 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 766760009679 active site 766760009680 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 766760009681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760009682 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 766760009683 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 766760009684 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 766760009685 active site 766760009686 dimer interface [polypeptide binding]; other site 766760009687 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 766760009688 Ligand Binding Site [chemical binding]; other site 766760009689 Molecular Tunnel; other site 766760009690 S-adenosylmethionine synthetase; Validated; Region: PRK05250 766760009691 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 766760009692 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 766760009693 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 766760009694 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 766760009695 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 766760009696 active site 766760009697 substrate-binding site [chemical binding]; other site 766760009698 metal-binding site [ion binding] 766760009699 ATP binding site [chemical binding]; other site 766760009700 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 766760009701 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 766760009702 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 766760009703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760009704 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760009705 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 766760009706 NMT1-like family; Region: NMT1_2; pfam13379 766760009707 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 766760009708 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 766760009709 Walker A/P-loop; other site 766760009710 ATP binding site [chemical binding]; other site 766760009711 Q-loop/lid; other site 766760009712 ABC transporter signature motif; other site 766760009713 Walker B; other site 766760009714 D-loop; other site 766760009715 H-loop/switch region; other site 766760009716 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 766760009717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760009718 dimer interface [polypeptide binding]; other site 766760009719 conserved gate region; other site 766760009720 putative PBP binding loops; other site 766760009721 ABC-ATPase subunit interface; other site 766760009722 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 766760009723 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 766760009724 nudix motif; other site 766760009725 Holin family; Region: Phage_holin_4; cl01989 766760009726 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 766760009727 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 766760009728 dimerization interface [polypeptide binding]; other site 766760009729 DPS ferroxidase diiron center [ion binding]; other site 766760009730 ion pore; other site 766760009731 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 766760009732 YtkA-like; Region: YtkA; pfam13115 766760009733 S-ribosylhomocysteinase; Provisional; Region: PRK02260 766760009734 Haemolytic domain; Region: Haemolytic; pfam01809 766760009735 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 766760009736 active site clefts [active] 766760009737 zinc binding site [ion binding]; other site 766760009738 dimer interface [polypeptide binding]; other site 766760009739 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 766760009740 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 766760009741 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 766760009742 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 766760009743 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 766760009744 intersubunit interface [polypeptide binding]; other site 766760009745 Transposase domain (DUF772); Region: DUF772; pfam05598 766760009746 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 766760009747 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 766760009748 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 766760009749 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 766760009750 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 766760009751 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 766760009752 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 766760009753 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 766760009754 active site 766760009755 octamer interface [polypeptide binding]; other site 766760009756 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 766760009757 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 766760009758 acyl-activating enzyme (AAE) consensus motif; other site 766760009759 putative AMP binding site [chemical binding]; other site 766760009760 putative active site [active] 766760009761 putative CoA binding site [chemical binding]; other site 766760009762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760009763 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 766760009764 substrate binding site [chemical binding]; other site 766760009765 oxyanion hole (OAH) forming residues; other site 766760009766 trimer interface [polypeptide binding]; other site 766760009767 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 766760009768 S-formylglutathione hydrolase; Region: PLN02442 766760009769 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 766760009770 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 766760009771 dimer interface [polypeptide binding]; other site 766760009772 tetramer interface [polypeptide binding]; other site 766760009773 PYR/PP interface [polypeptide binding]; other site 766760009774 TPP binding site [chemical binding]; other site 766760009775 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 766760009776 TPP-binding site; other site 766760009777 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 766760009778 isochorismate synthases; Region: isochor_syn; TIGR00543 766760009779 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 766760009780 UbiA prenyltransferase family; Region: UbiA; pfam01040 766760009781 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 766760009782 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 766760009783 homodimer interface [polypeptide binding]; other site 766760009784 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 766760009785 active site pocket [active] 766760009786 glycogen synthase; Provisional; Region: glgA; PRK00654 766760009787 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 766760009788 ADP-binding pocket [chemical binding]; other site 766760009789 homodimer interface [polypeptide binding]; other site 766760009790 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 766760009791 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 766760009792 ligand binding site; other site 766760009793 oligomer interface; other site 766760009794 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 766760009795 dimer interface [polypeptide binding]; other site 766760009796 N-terminal domain interface [polypeptide binding]; other site 766760009797 sulfate 1 binding site; other site 766760009798 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 766760009799 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 766760009800 ligand binding site; other site 766760009801 oligomer interface; other site 766760009802 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 766760009803 dimer interface [polypeptide binding]; other site 766760009804 N-terminal domain interface [polypeptide binding]; other site 766760009805 sulfate 1 binding site; other site 766760009806 glycogen branching enzyme; Provisional; Region: PRK12313 766760009807 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 766760009808 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 766760009809 active site 766760009810 catalytic site [active] 766760009811 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 766760009812 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 766760009813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760009814 DNA-binding site [nucleotide binding]; DNA binding site 766760009815 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 766760009816 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 766760009817 putative dimerization interface [polypeptide binding]; other site 766760009818 putative ligand binding site [chemical binding]; other site 766760009819 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 766760009820 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 766760009821 active site 766760009822 catalytic site [active] 766760009823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760009824 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 766760009825 putative substrate binding pocket [chemical binding]; other site 766760009826 AC domain interface; other site 766760009827 catalytic triad [active] 766760009828 AB domain interface; other site 766760009829 interchain disulfide; other site 766760009830 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 766760009831 TrkA-N domain; Region: TrkA_N; pfam02254 766760009832 TrkA-C domain; Region: TrkA_C; pfam02080 766760009833 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 766760009834 EamA-like transporter family; Region: EamA; pfam00892 766760009835 DinB superfamily; Region: DinB_2; pfam12867 766760009836 metal-dependent hydrolase; Provisional; Region: PRK13291 766760009837 MOSC domain; Region: MOSC; pfam03473 766760009838 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 766760009839 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 766760009840 active site 766760009841 NAD binding site [chemical binding]; other site 766760009842 metal binding site [ion binding]; metal-binding site 766760009843 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 766760009844 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 766760009845 tetramerization interface [polypeptide binding]; other site 766760009846 NAD(P) binding site [chemical binding]; other site 766760009847 catalytic residues [active] 766760009848 Predicted transcriptional regulators [Transcription]; Region: COG1510 766760009849 MarR family; Region: MarR_2; pfam12802 766760009850 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 766760009851 Na binding site [ion binding]; other site 766760009852 putative glycosylation site [posttranslational modification]; other site 766760009853 putative glycosylation site [posttranslational modification]; other site 766760009854 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 766760009855 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 766760009856 alanine racemase; Region: alr; TIGR00492 766760009857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 766760009858 active site 766760009859 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 766760009860 dimer interface [polypeptide binding]; other site 766760009861 substrate binding site [chemical binding]; other site 766760009862 catalytic residues [active] 766760009863 Cupin; Region: Cupin_1; smart00835 766760009864 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 766760009865 Cupin; Region: Cupin_1; smart00835 766760009866 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 766760009867 Immunity protein Imm3; Region: Imm3; pfam14425 766760009868 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 766760009869 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 766760009870 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 766760009871 catalytic residues [active] 766760009872 Recombinase; Region: Recombinase; pfam07508 766760009873 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 766760009874 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 766760009875 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 766760009876 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 766760009877 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 766760009878 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 766760009879 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 766760009880 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 766760009881 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 766760009882 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 766760009883 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 766760009884 putative active site [active] 766760009885 putative metal binding site [ion binding]; other site 766760009886 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 766760009887 Domain of unknown function DUF20; Region: UPF0118; pfam01594 766760009888 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 766760009889 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760009890 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760009891 intracellular protease, PfpI family; Region: PfpI; TIGR01382 766760009892 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 766760009893 proposed catalytic triad [active] 766760009894 conserved cys residue [active] 766760009895 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 766760009896 Cache domain; Region: Cache_1; pfam02743 766760009897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760009898 dimerization interface [polypeptide binding]; other site 766760009899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760009900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760009901 dimer interface [polypeptide binding]; other site 766760009902 putative CheW interface [polypeptide binding]; other site 766760009903 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 766760009904 Cache domain; Region: Cache_1; pfam02743 766760009905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760009906 dimerization interface [polypeptide binding]; other site 766760009907 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760009908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760009909 dimer interface [polypeptide binding]; other site 766760009910 putative CheW interface [polypeptide binding]; other site 766760009911 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 766760009912 Cache domain; Region: Cache_1; pfam02743 766760009913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760009914 dimerization interface [polypeptide binding]; other site 766760009915 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760009916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760009917 dimer interface [polypeptide binding]; other site 766760009918 putative CheW interface [polypeptide binding]; other site 766760009919 transglutaminase; Provisional; Region: tgl; PRK03187 766760009920 Nitronate monooxygenase; Region: NMO; pfam03060 766760009921 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 766760009922 FMN binding site [chemical binding]; other site 766760009923 substrate binding site [chemical binding]; other site 766760009924 putative catalytic residue [active] 766760009925 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 766760009926 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 766760009927 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 766760009928 Ca binding site [ion binding]; other site 766760009929 active site 766760009930 catalytic site [active] 766760009931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760009932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760009933 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 766760009934 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 766760009935 Domain of unknown function DUF21; Region: DUF21; pfam01595 766760009936 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 766760009937 Transporter associated domain; Region: CorC_HlyC; smart01091 766760009938 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 766760009939 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 766760009940 Ion channel; Region: Ion_trans_2; pfam07885 766760009941 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 766760009942 TrkA-N domain; Region: TrkA_N; pfam02254 766760009943 Calcium-activated BK potassium channel alpha subunit; Region: BK_channel_a; pfam03493 766760009944 YugN-like family; Region: YugN; pfam08868 766760009945 Predicted membrane protein [Function unknown]; Region: COG2323 766760009946 TspO/MBR family; Region: TspO_MBR; pfam03073 766760009947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760009948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760009949 Coenzyme A binding pocket [chemical binding]; other site 766760009950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760009951 H-loop/switch region; other site 766760009952 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 766760009953 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 766760009954 active site 766760009955 dimer interface [polypeptide binding]; other site 766760009956 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 766760009957 dimer interface [polypeptide binding]; other site 766760009958 active site 766760009959 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 766760009960 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 766760009961 dimer interface [polypeptide binding]; other site 766760009962 active site 766760009963 metal binding site [ion binding]; metal-binding site 766760009964 Uncharacterized conserved protein [Function unknown]; Region: COG2155 766760009965 general stress protein 13; Validated; Region: PRK08059 766760009966 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 766760009967 RNA binding site [nucleotide binding]; other site 766760009968 hypothetical protein; Validated; Region: PRK07682 766760009969 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760009970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760009971 homodimer interface [polypeptide binding]; other site 766760009972 catalytic residue [active] 766760009973 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 766760009974 AsnC family; Region: AsnC_trans_reg; pfam01037 766760009975 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 766760009976 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 766760009977 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 766760009978 nucleophilic elbow; other site 766760009979 catalytic site [active] 766760009980 catalytic triad; other site 766760009981 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 766760009982 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 766760009983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760009984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760009985 homodimer interface [polypeptide binding]; other site 766760009986 catalytic residue [active] 766760009987 Kinase associated protein B; Region: KapB; pfam08810 766760009988 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 766760009989 active site 766760009990 catalytic site [active] 766760009991 substrate binding site [chemical binding]; other site 766760009992 drug efflux system protein MdtG; Provisional; Region: PRK09874 766760009993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760009994 putative substrate translocation pore; other site 766760009995 Transglycosylase; Region: Transgly; pfam00912 766760009996 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 766760009997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 766760009998 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 766760009999 sensory histidine kinase DcuS; Provisional; Region: PRK11086 766760010000 PAS domain; Region: PAS; smart00091 766760010001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760010002 ATP binding site [chemical binding]; other site 766760010003 Mg2+ binding site [ion binding]; other site 766760010004 G-X-G motif; other site 766760010005 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 766760010006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760010007 active site 766760010008 phosphorylation site [posttranslational modification] 766760010009 intermolecular recognition site; other site 766760010010 dimerization interface [polypeptide binding]; other site 766760010011 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 766760010012 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 766760010013 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 766760010014 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 766760010015 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 766760010016 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 766760010017 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 766760010018 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 766760010019 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 766760010020 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 766760010021 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 766760010022 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 766760010023 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 766760010024 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 766760010025 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 766760010026 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 766760010027 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 766760010028 CoenzymeA binding site [chemical binding]; other site 766760010029 subunit interaction site [polypeptide binding]; other site 766760010030 PHB binding site; other site 766760010031 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760010032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760010033 active site 766760010034 phosphorylation site [posttranslational modification] 766760010035 intermolecular recognition site; other site 766760010036 dimerization interface [polypeptide binding]; other site 766760010037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760010038 DNA binding residues [nucleotide binding] 766760010039 dimerization interface [polypeptide binding]; other site 766760010040 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 766760010041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760010042 Histidine kinase; Region: HisKA_3; pfam07730 766760010043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760010044 ATP binding site [chemical binding]; other site 766760010045 Mg2+ binding site [ion binding]; other site 766760010046 G-X-G motif; other site 766760010047 Bacillus competence pheromone ComX; Region: ComX; pfam05952 766760010048 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 766760010049 substrate binding pocket [chemical binding]; other site 766760010050 aspartate-rich region 2; other site 766760010051 substrate-Mg2+ binding site; other site 766760010052 DegQ (SacQ) family; Region: DegQ; pfam08181 766760010053 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 766760010054 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 766760010055 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 766760010056 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 766760010057 active site 766760010058 Isochorismatase family; Region: Isochorismatase; pfam00857 766760010059 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 766760010060 catalytic triad [active] 766760010061 conserved cis-peptide bond; other site 766760010062 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 766760010063 YueH-like protein; Region: YueH; pfam14166 766760010064 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 766760010065 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 766760010066 Domain of unknown function DUF20; Region: UPF0118; pfam01594 766760010067 Rrf2 family protein; Region: rrf2_super; TIGR00738 766760010068 Transcriptional regulator; Region: Rrf2; pfam02082 766760010069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760010070 PGAP1-like protein; Region: PGAP1; pfam07819 766760010071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 766760010072 Zn2+ binding site [ion binding]; other site 766760010073 Mg2+ binding site [ion binding]; other site 766760010074 short chain dehydrogenase; Provisional; Region: PRK06924 766760010075 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 766760010076 NADP binding site [chemical binding]; other site 766760010077 homodimer interface [polypeptide binding]; other site 766760010078 active site 766760010079 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 766760010080 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 766760010081 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 766760010082 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 766760010083 Predicted membrane protein [Function unknown]; Region: COG1511 766760010084 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 766760010085 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 766760010086 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 766760010087 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 766760010088 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 766760010089 Domain of unknown function DUF87; Region: DUF87; pfam01935 766760010090 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 766760010091 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 766760010092 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 766760010093 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 766760010094 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 766760010095 amino acid carrier protein; Region: agcS; TIGR00835 766760010096 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 766760010097 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 766760010098 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 766760010099 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 766760010100 hexamer interface [polypeptide binding]; other site 766760010101 ligand binding site [chemical binding]; other site 766760010102 putative active site [active] 766760010103 NAD(P) binding site [chemical binding]; other site 766760010104 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 766760010105 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 766760010106 Moco binding site; other site 766760010107 metal coordination site [ion binding]; other site 766760010108 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 766760010109 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 766760010110 Predicted permease [General function prediction only]; Region: COG2056 766760010111 AbgT putative transporter family; Region: ABG_transport; cl17431 766760010112 multifunctional aminopeptidase A; Provisional; Region: PRK00913 766760010113 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 766760010114 interface (dimer of trimers) [polypeptide binding]; other site 766760010115 Substrate-binding/catalytic site; other site 766760010116 Zn-binding sites [ion binding]; other site 766760010117 Divergent PAP2 family; Region: DUF212; pfam02681 766760010118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 766760010119 Putative membrane protein; Region: YuiB; pfam14068 766760010120 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 766760010121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760010122 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 766760010123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760010124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760010125 Cold-inducible protein YdjO; Region: YdjO; pfam14169 766760010126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 766760010127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760010128 Coenzyme A binding pocket [chemical binding]; other site 766760010129 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 766760010130 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 766760010131 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 766760010132 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 766760010133 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 766760010134 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 766760010135 Nucleoside recognition; Region: Gate; pfam07670 766760010136 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 766760010137 hypothetical protein; Provisional; Region: PRK13669 766760010138 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 766760010139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760010140 Predicted membrane protein [Function unknown]; Region: COG2323 766760010141 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 766760010142 Ferritin-like domain; Region: Ferritin; pfam00210 766760010143 dinuclear metal binding motif [ion binding]; other site 766760010144 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 766760010145 diiron binding motif [ion binding]; other site 766760010146 Uncharacterized conserved protein [Function unknown]; Region: COG5646 766760010147 Dienelactone hydrolase family; Region: DLH; pfam01738 766760010148 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 766760010149 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 766760010150 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 766760010151 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 766760010152 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 766760010153 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 766760010154 structural tetrad; other site 766760010155 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 766760010156 homoserine kinase; Provisional; Region: PRK01212 766760010157 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 766760010158 threonine synthase; Reviewed; Region: PRK06721 766760010159 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 766760010160 homodimer interface [polypeptide binding]; other site 766760010161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760010162 catalytic residue [active] 766760010163 homoserine dehydrogenase; Provisional; Region: PRK06349 766760010164 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 766760010165 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 766760010166 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 766760010167 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 766760010168 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 766760010169 dimerization interface [polypeptide binding]; other site 766760010170 ligand binding site [chemical binding]; other site 766760010171 NADP binding site [chemical binding]; other site 766760010172 catalytic site [active] 766760010173 spore coat protein YutH; Region: spore_yutH; TIGR02905 766760010174 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 766760010175 tetramer interfaces [polypeptide binding]; other site 766760010176 binuclear metal-binding site [ion binding]; other site 766760010177 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 766760010178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760010179 active site 766760010180 motif I; other site 766760010181 motif II; other site 766760010182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760010183 Uncharacterized conserved protein [Function unknown]; Region: COG2445 766760010184 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 766760010185 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 766760010186 lipoyl synthase; Provisional; Region: PRK05481 766760010187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760010188 FeS/SAM binding site; other site 766760010189 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 766760010190 Peptidase family M23; Region: Peptidase_M23; pfam01551 766760010191 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 766760010192 Na2 binding site [ion binding]; other site 766760010193 putative substrate binding site 1 [chemical binding]; other site 766760010194 Na binding site 1 [ion binding]; other site 766760010195 putative substrate binding site 2 [chemical binding]; other site 766760010196 sporulation protein YunB; Region: spo_yunB; TIGR02832 766760010197 Uncharacterized conserved protein [Function unknown]; Region: COG3377 766760010198 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 766760010199 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 766760010200 active site 766760010201 metal binding site [ion binding]; metal-binding site 766760010202 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 766760010203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 766760010204 Uncharacterized conserved protein [Function unknown]; Region: COG1801 766760010205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760010206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760010207 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 766760010208 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 766760010209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760010210 catalytic residue [active] 766760010211 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 766760010212 DRTGG domain; Region: DRTGG; pfam07085 766760010213 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 766760010214 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 766760010215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760010217 putative substrate translocation pore; other site 766760010218 Predicted membrane protein [Function unknown]; Region: COG1288 766760010219 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 766760010220 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 766760010221 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 766760010222 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 766760010223 Endonuclease I; Region: Endonuclease_1; pfam04231 766760010224 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 766760010225 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 766760010226 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 766760010227 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 766760010228 EamA-like transporter family; Region: EamA; cl17759 766760010229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 766760010230 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 766760010231 FeS assembly protein SufB; Region: sufB; TIGR01980 766760010232 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 766760010233 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 766760010234 trimerization site [polypeptide binding]; other site 766760010235 active site 766760010236 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 766760010237 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 766760010238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760010239 catalytic residue [active] 766760010240 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 766760010241 FeS assembly protein SufD; Region: sufD; TIGR01981 766760010242 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 766760010243 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 766760010244 Walker A/P-loop; other site 766760010245 ATP binding site [chemical binding]; other site 766760010246 Q-loop/lid; other site 766760010247 ABC transporter signature motif; other site 766760010248 Walker B; other site 766760010249 D-loop; other site 766760010250 H-loop/switch region; other site 766760010251 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 766760010252 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 766760010253 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 766760010254 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 766760010255 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 766760010256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760010257 dimer interface [polypeptide binding]; other site 766760010258 conserved gate region; other site 766760010259 putative PBP binding loops; other site 766760010260 ABC-ATPase subunit interface; other site 766760010261 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 766760010262 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 766760010263 Walker A/P-loop; other site 766760010264 ATP binding site [chemical binding]; other site 766760010265 Q-loop/lid; other site 766760010266 ABC transporter signature motif; other site 766760010267 Walker B; other site 766760010268 D-loop; other site 766760010269 H-loop/switch region; other site 766760010270 NIL domain; Region: NIL; pfam09383 766760010271 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 766760010272 catalytic residues [active] 766760010273 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 766760010274 putative active site [active] 766760010275 putative metal binding site [ion binding]; other site 766760010276 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 766760010277 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 766760010278 lipoyl attachment site [posttranslational modification]; other site 766760010279 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 766760010280 ArsC family; Region: ArsC; pfam03960 766760010281 putative ArsC-like catalytic residues; other site 766760010282 putative TRX-like catalytic residues [active] 766760010283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 766760010284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 766760010285 active site 766760010286 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 766760010287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 766760010288 dimer interface [polypeptide binding]; other site 766760010289 active site 766760010290 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 766760010291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 766760010292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 766760010293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 766760010294 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 766760010295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 766760010296 substrate binding site [chemical binding]; other site 766760010297 oxyanion hole (OAH) forming residues; other site 766760010298 trimer interface [polypeptide binding]; other site 766760010299 YuzL-like protein; Region: YuzL; pfam14115 766760010300 Coat F domain; Region: Coat_F; pfam07875 766760010301 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 766760010302 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 766760010303 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 766760010304 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 766760010305 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 766760010306 Walker A/P-loop; other site 766760010307 ATP binding site [chemical binding]; other site 766760010308 Q-loop/lid; other site 766760010309 ABC transporter signature motif; other site 766760010310 Walker B; other site 766760010311 D-loop; other site 766760010312 H-loop/switch region; other site 766760010313 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 766760010314 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760010315 ABC-ATPase subunit interface; other site 766760010316 dimer interface [polypeptide binding]; other site 766760010317 putative PBP binding regions; other site 766760010318 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 766760010319 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760010320 ABC-ATPase subunit interface; other site 766760010321 dimer interface [polypeptide binding]; other site 766760010322 putative PBP binding regions; other site 766760010323 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760010324 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 766760010325 siderophore binding site; other site 766760010326 YusW-like protein; Region: YusW; pfam14039 766760010327 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 766760010328 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 766760010329 active site 766760010330 Zn binding site [ion binding]; other site 766760010331 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 766760010332 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 766760010333 short chain dehydrogenase; Provisional; Region: PRK06914 766760010334 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 766760010335 NADP binding site [chemical binding]; other site 766760010336 active site 766760010337 steroid binding site; other site 766760010338 Ferritin-like domain; Region: Ferritin; pfam00210 766760010339 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 766760010340 dimerization interface [polypeptide binding]; other site 766760010341 DPS ferroxidase diiron center [ion binding]; other site 766760010342 ion pore; other site 766760010343 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 766760010344 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 766760010345 protein binding site [polypeptide binding]; other site 766760010346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760010347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760010348 active site 766760010349 phosphorylation site [posttranslational modification] 766760010350 intermolecular recognition site; other site 766760010351 dimerization interface [polypeptide binding]; other site 766760010352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760010353 DNA binding site [nucleotide binding] 766760010354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760010355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760010356 dimerization interface [polypeptide binding]; other site 766760010357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760010358 dimer interface [polypeptide binding]; other site 766760010359 phosphorylation site [posttranslational modification] 766760010360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760010361 ATP binding site [chemical binding]; other site 766760010362 Mg2+ binding site [ion binding]; other site 766760010363 G-X-G motif; other site 766760010364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 766760010365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 766760010366 fumarate hydratase; Reviewed; Region: fumC; PRK00485 766760010367 Class II fumarases; Region: Fumarase_classII; cd01362 766760010368 active site 766760010369 tetramer interface [polypeptide binding]; other site 766760010370 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 766760010371 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 766760010372 Spore germination protein; Region: Spore_permease; cl17796 766760010373 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 766760010374 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 766760010375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760010376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760010377 active site 766760010378 phosphorylation site [posttranslational modification] 766760010379 intermolecular recognition site; other site 766760010380 dimerization interface [polypeptide binding]; other site 766760010381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760010382 DNA binding residues [nucleotide binding] 766760010383 dimerization interface [polypeptide binding]; other site 766760010384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760010385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760010386 dimerization interface [polypeptide binding]; other site 766760010387 Histidine kinase; Region: HisKA_3; pfam07730 766760010388 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 766760010389 ATP binding site [chemical binding]; other site 766760010390 Mg2+ binding site [ion binding]; other site 766760010391 G-X-G motif; other site 766760010392 Predicted membrane protein [Function unknown]; Region: COG4758 766760010393 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 766760010394 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 766760010395 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 766760010396 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 766760010397 PspA/IM30 family; Region: PspA_IM30; pfam04012 766760010398 Interleukin 10; Region: IL10; cl02501 766760010399 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 766760010400 putative pectinesterase; Region: PLN02432; cl01911 766760010401 Pectinesterase; Region: Pectinesterase; pfam01095 766760010402 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 766760010403 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 766760010404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760010405 NAD(P) binding site [chemical binding]; other site 766760010406 active site 766760010407 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 766760010408 BNR repeat-like domain; Region: BNR_2; pfam13088 766760010409 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 766760010410 Asp-box motif; other site 766760010411 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 766760010412 Na binding site [ion binding]; other site 766760010413 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 766760010414 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 766760010415 putative active site [active] 766760010416 metal binding site [ion binding]; metal-binding site 766760010417 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 766760010418 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 766760010419 inhibitor site; inhibition site 766760010420 active site 766760010421 dimer interface [polypeptide binding]; other site 766760010422 catalytic residue [active] 766760010423 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 766760010424 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 766760010425 Walker A/P-loop; other site 766760010426 ATP binding site [chemical binding]; other site 766760010427 Q-loop/lid; other site 766760010428 ABC transporter signature motif; other site 766760010429 Walker B; other site 766760010430 D-loop; other site 766760010431 H-loop/switch region; other site 766760010432 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 766760010433 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760010434 ABC-ATPase subunit interface; other site 766760010435 dimer interface [polypeptide binding]; other site 766760010436 putative PBP binding regions; other site 766760010437 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760010438 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 766760010439 putative binding site residues; other site 766760010440 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760010441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760010442 DNA-binding site [nucleotide binding]; DNA binding site 766760010443 FCD domain; Region: FCD; pfam07729 766760010444 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 766760010445 classical (c) SDRs; Region: SDR_c; cd05233 766760010446 NAD(P) binding site [chemical binding]; other site 766760010447 active site 766760010448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 766760010449 MOSC domain; Region: MOSC; pfam03473 766760010450 3-alpha domain; Region: 3-alpha; pfam03475 766760010451 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 766760010452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760010453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760010454 dimerization interface [polypeptide binding]; other site 766760010455 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 766760010456 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 766760010457 galactarate dehydratase; Region: galactar-dH20; TIGR03248 766760010458 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 766760010459 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 766760010460 altronate oxidoreductase; Provisional; Region: PRK03643 766760010461 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 766760010462 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 766760010463 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760010464 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760010465 DNA binding site [nucleotide binding] 766760010466 domain linker motif; other site 766760010467 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 766760010468 dimerization interface [polypeptide binding]; other site 766760010469 ligand binding site [chemical binding]; other site 766760010470 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 766760010471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010472 putative substrate translocation pore; other site 766760010473 Glucuronate isomerase; Region: UxaC; pfam02614 766760010474 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 766760010475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760010476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760010477 dimer interface [polypeptide binding]; other site 766760010478 phosphorylation site [posttranslational modification] 766760010479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760010480 ATP binding site [chemical binding]; other site 766760010481 Mg2+ binding site [ion binding]; other site 766760010482 G-X-G motif; other site 766760010483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760010484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760010485 active site 766760010486 phosphorylation site [posttranslational modification] 766760010487 intermolecular recognition site; other site 766760010488 dimerization interface [polypeptide binding]; other site 766760010489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760010490 DNA binding site [nucleotide binding] 766760010491 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 766760010492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 766760010493 Walker A/P-loop; other site 766760010494 ATP binding site [chemical binding]; other site 766760010495 Q-loop/lid; other site 766760010496 ABC transporter signature motif; other site 766760010497 Walker B; other site 766760010498 D-loop; other site 766760010499 H-loop/switch region; other site 766760010500 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 766760010501 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760010502 ABC-ATPase subunit interface; other site 766760010503 dimer interface [polypeptide binding]; other site 766760010504 putative PBP binding regions; other site 766760010505 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 766760010506 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760010507 ABC-ATPase subunit interface; other site 766760010508 dimer interface [polypeptide binding]; other site 766760010509 putative PBP binding regions; other site 766760010510 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 766760010511 Spore germination protein; Region: Spore_permease; cl17796 766760010512 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 766760010513 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 766760010514 Sulfatase; Region: Sulfatase; pfam00884 766760010515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760010517 putative substrate translocation pore; other site 766760010518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010519 putative substrate translocation pore; other site 766760010520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 766760010521 active site 766760010522 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 766760010523 catalytic tetrad [active] 766760010524 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 766760010525 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 766760010526 nucleotide binding site [chemical binding]; other site 766760010527 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 766760010528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 766760010529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 766760010530 catalytic residue [active] 766760010531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 766760010532 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 766760010533 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 766760010534 Family description; Region: UvrD_C_2; pfam13538 766760010535 Predicted membrane protein [Function unknown]; Region: COG2860 766760010536 UPF0126 domain; Region: UPF0126; pfam03458 766760010537 UPF0126 domain; Region: UPF0126; pfam03458 766760010538 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 766760010539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 766760010540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760010541 Coenzyme A binding pocket [chemical binding]; other site 766760010542 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 766760010543 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 766760010544 Thioredoxin; Region: Thioredoxin_4; pfam13462 766760010545 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 766760010546 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 766760010547 metal-binding site [ion binding] 766760010548 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 766760010549 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 766760010550 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760010551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 766760010552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760010553 dimer interface [polypeptide binding]; other site 766760010554 conserved gate region; other site 766760010555 putative PBP binding loops; other site 766760010556 ABC-ATPase subunit interface; other site 766760010557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760010558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760010559 dimer interface [polypeptide binding]; other site 766760010560 conserved gate region; other site 766760010561 putative PBP binding loops; other site 766760010562 ABC-ATPase subunit interface; other site 766760010563 putative alpha-glucosidase; Provisional; Region: PRK10658 766760010564 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 766760010565 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 766760010566 active site 766760010567 homotrimer interface [polypeptide binding]; other site 766760010568 catalytic site [active] 766760010569 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 766760010570 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 766760010571 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 766760010572 PKC phosphorylation site [posttranslational modification]; other site 766760010573 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 766760010574 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 766760010575 metal binding site [ion binding]; metal-binding site 766760010576 ligand binding site [chemical binding]; other site 766760010577 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 766760010578 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 766760010579 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 766760010580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760010581 dimer interface [polypeptide binding]; other site 766760010582 ABC-ATPase subunit interface; other site 766760010583 putative PBP binding regions; other site 766760010584 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 766760010585 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 766760010586 metal binding site [ion binding]; metal-binding site 766760010587 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 766760010588 dimerization interface [polypeptide binding]; other site 766760010589 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 766760010590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 766760010591 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 766760010592 putative active site [active] 766760010593 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 766760010594 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 766760010595 putative substrate binding site [chemical binding]; other site 766760010596 putative ATP binding site [chemical binding]; other site 766760010597 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 766760010598 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 766760010599 active site 766760010600 P-loop; other site 766760010601 phosphorylation site [posttranslational modification] 766760010602 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 766760010603 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760010604 active site 766760010605 phosphorylation site [posttranslational modification] 766760010606 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 766760010607 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 766760010608 intersubunit interface [polypeptide binding]; other site 766760010609 active site 766760010610 zinc binding site [ion binding]; other site 766760010611 Na+ binding site [ion binding]; other site 766760010612 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 766760010613 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 766760010614 metal-binding site [ion binding] 766760010615 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 766760010616 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 766760010617 metal-binding site [ion binding] 766760010618 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 766760010619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760010620 motif II; other site 766760010621 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 766760010622 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 766760010623 metal-binding site [ion binding] 766760010624 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 766760010625 putative homodimer interface [polypeptide binding]; other site 766760010626 putative homotetramer interface [polypeptide binding]; other site 766760010627 allosteric switch controlling residues; other site 766760010628 putative metal binding site [ion binding]; other site 766760010629 putative homodimer-homodimer interface [polypeptide binding]; other site 766760010630 intracellular protease, PfpI family; Region: PfpI; TIGR01382 766760010631 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 766760010632 conserved cys residue [active] 766760010633 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 766760010634 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 766760010635 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 766760010636 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 766760010637 N- and C-terminal domain interface [polypeptide binding]; other site 766760010638 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 766760010639 active site 766760010640 putative catalytic site [active] 766760010641 metal binding site [ion binding]; metal-binding site 766760010642 ATP binding site [chemical binding]; other site 766760010643 carbohydrate binding site [chemical binding]; other site 766760010644 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 766760010645 L-rhamnose isomerase, Streptomyces subtype; Region: RhaI_grampos; TIGR02635 766760010646 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 766760010647 short chain dehydrogenase; Validated; Region: PRK08324 766760010648 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 766760010649 intersubunit interface [polypeptide binding]; other site 766760010650 active site 766760010651 Zn2+ binding site [ion binding]; other site 766760010652 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 766760010653 putative NAD(P) binding site [chemical binding]; other site 766760010654 active site 766760010655 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 766760010656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010657 putative substrate translocation pore; other site 766760010658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760010660 putative substrate translocation pore; other site 766760010661 Cytochrome P450; Region: p450; cl12078 766760010662 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 766760010663 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 766760010664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760010665 putative DNA binding site [nucleotide binding]; other site 766760010666 dimerization interface [polypeptide binding]; other site 766760010667 putative Zn2+ binding site [ion binding]; other site 766760010668 indole-3-acetamide amidohydrolase; Region: PLN02722 766760010669 Amidase; Region: Amidase; cl11426 766760010670 putative oxidoreductase; Provisional; Region: PRK11579 766760010671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760010672 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 766760010673 azoreductase; Reviewed; Region: PRK00170 766760010674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760010675 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 766760010676 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 766760010677 active site residue [active] 766760010678 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 766760010679 hypothetical protein; Provisional; Region: PRK14082 766760010680 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 766760010681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760010682 DNA binding residues [nucleotide binding] 766760010683 YvrJ protein family; Region: YvrJ; pfam12841 766760010684 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 766760010685 Cupin; Region: Cupin_1; smart00835 766760010686 Cupin; Region: Cupin_1; smart00835 766760010687 Regulatory protein YrvL; Region: YrvL; pfam14184 766760010688 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 766760010689 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 766760010690 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 766760010691 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 766760010692 substrate binding site [chemical binding]; other site 766760010693 active site 766760010694 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 766760010695 metal binding site [ion binding]; metal-binding site 766760010696 ligand binding site [chemical binding]; other site 766760010697 YcxB-like protein; Region: YcxB; pfam14317 766760010698 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760010699 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 766760010700 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 766760010701 SmpB-tmRNA interface; other site 766760010702 ribonuclease R; Region: RNase_R; TIGR02063 766760010703 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 766760010704 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 766760010705 RNB domain; Region: RNB; pfam00773 766760010706 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 766760010707 RNA binding site [nucleotide binding]; other site 766760010708 Esterase/lipase [General function prediction only]; Region: COG1647 766760010709 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 766760010710 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 766760010711 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 766760010712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760010713 salt bridge; other site 766760010714 non-specific DNA binding site [nucleotide binding]; other site 766760010715 sequence-specific DNA binding site [nucleotide binding]; other site 766760010716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760010717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760010718 non-specific DNA binding site [nucleotide binding]; other site 766760010719 salt bridge; other site 766760010720 sequence-specific DNA binding site [nucleotide binding]; other site 766760010721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760010722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760010723 non-specific DNA binding site [nucleotide binding]; other site 766760010724 salt bridge; other site 766760010725 sequence-specific DNA binding site [nucleotide binding]; other site 766760010726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760010727 dimer interface [polypeptide binding]; other site 766760010728 conserved gate region; other site 766760010729 putative PBP binding loops; other site 766760010730 ABC-ATPase subunit interface; other site 766760010731 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 766760010732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760010733 dimer interface [polypeptide binding]; other site 766760010734 conserved gate region; other site 766760010735 ABC-ATPase subunit interface; other site 766760010736 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 766760010737 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 766760010738 Walker A/P-loop; other site 766760010739 ATP binding site [chemical binding]; other site 766760010740 Q-loop/lid; other site 766760010741 ABC transporter signature motif; other site 766760010742 Walker B; other site 766760010743 D-loop; other site 766760010744 H-loop/switch region; other site 766760010745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 766760010746 Predicted transcriptional regulators [Transcription]; Region: COG1510 766760010747 MarR family; Region: MarR_2; pfam12802 766760010748 membrane protein, MarC family; Region: TIGR00427 766760010749 Double zinc ribbon; Region: DZR; pfam12773 766760010750 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 766760010751 Predicted membrane protein [Function unknown]; Region: COG4640 766760010752 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 766760010753 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760010754 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 766760010755 siderophore binding site; other site 766760010756 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 766760010757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760010758 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 766760010759 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 766760010760 conserved cys residue [active] 766760010761 enolase; Provisional; Region: eno; PRK00077 766760010762 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 766760010763 dimer interface [polypeptide binding]; other site 766760010764 metal binding site [ion binding]; metal-binding site 766760010765 substrate binding pocket [chemical binding]; other site 766760010766 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 766760010767 phosphoglyceromutase; Provisional; Region: PRK05434 766760010768 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 766760010769 triosephosphate isomerase; Provisional; Region: PRK14565 766760010770 substrate binding site [chemical binding]; other site 766760010771 dimer interface [polypeptide binding]; other site 766760010772 catalytic triad [active] 766760010773 Phosphoglycerate kinase; Region: PGK; pfam00162 766760010774 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 766760010775 substrate binding site [chemical binding]; other site 766760010776 hinge regions; other site 766760010777 ADP binding site [chemical binding]; other site 766760010778 catalytic site [active] 766760010779 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 766760010780 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 766760010781 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 766760010782 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 766760010783 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 766760010784 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 766760010785 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 766760010786 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 766760010787 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760010788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760010789 Walker A/P-loop; other site 766760010790 ATP binding site [chemical binding]; other site 766760010791 Q-loop/lid; other site 766760010792 ABC transporter signature motif; other site 766760010793 Walker B; other site 766760010794 D-loop; other site 766760010795 H-loop/switch region; other site 766760010796 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 766760010797 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 766760010798 Uncharacterized conserved protein [Function unknown]; Region: COG1556 766760010799 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 766760010800 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 766760010801 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 766760010802 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 766760010803 Cysteine-rich domain; Region: CCG; pfam02754 766760010804 Cysteine-rich domain; Region: CCG; pfam02754 766760010805 Transcriptional regulators [Transcription]; Region: FadR; COG2186 766760010806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760010807 DNA-binding site [nucleotide binding]; DNA binding site 766760010808 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 766760010809 L-lactate permease; Region: Lactate_perm; cl00701 766760010810 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 766760010811 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 766760010812 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 766760010813 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 766760010814 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 766760010815 YvfG protein; Region: YvfG; pfam09628 766760010816 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 766760010817 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 766760010818 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 766760010819 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 766760010820 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 766760010821 inhibitor-cofactor binding pocket; inhibition site 766760010822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760010823 catalytic residue [active] 766760010824 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 766760010825 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 766760010826 putative trimer interface [polypeptide binding]; other site 766760010827 putative CoA binding site [chemical binding]; other site 766760010828 Bacterial sugar transferase; Region: Bac_transf; pfam02397 766760010829 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 766760010830 putative glycosyl transferase; Provisional; Region: PRK10073 766760010831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 766760010832 active site 766760010833 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 766760010834 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 766760010835 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 766760010836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 766760010837 active site 766760010838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760010839 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 766760010840 putative ADP-binding pocket [chemical binding]; other site 766760010841 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 766760010842 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 766760010843 active site 766760010844 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 766760010845 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760010846 putative ADP-binding pocket [chemical binding]; other site 766760010847 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 766760010848 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 766760010849 NAD(P) binding site [chemical binding]; other site 766760010850 homodimer interface [polypeptide binding]; other site 766760010851 substrate binding site [chemical binding]; other site 766760010852 active site 766760010853 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 766760010854 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 766760010855 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 766760010856 Chain length determinant protein; Region: Wzz; cl15801 766760010857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760010858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760010859 non-specific DNA binding site [nucleotide binding]; other site 766760010860 salt bridge; other site 766760010861 sequence-specific DNA binding site [nucleotide binding]; other site 766760010862 Anti-repressor SinI; Region: SinI; pfam08671 766760010863 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 766760010864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760010865 D-galactonate transporter; Region: 2A0114; TIGR00893 766760010866 putative substrate translocation pore; other site 766760010867 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 766760010868 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 766760010869 putative ligand binding site [chemical binding]; other site 766760010870 putative NAD binding site [chemical binding]; other site 766760010871 catalytic site [active] 766760010872 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 766760010873 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 766760010874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 766760010875 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 766760010876 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 766760010877 putative active site [active] 766760010878 metal binding site [ion binding]; metal-binding site 766760010879 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 766760010880 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 766760010881 inhibitor site; inhibition site 766760010882 active site 766760010883 dimer interface [polypeptide binding]; other site 766760010884 catalytic residue [active] 766760010885 Propionate catabolism activator; Region: PrpR_N; pfam06506 766760010886 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 766760010887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 766760010888 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 766760010889 Predicted transcriptional regulators [Transcription]; Region: COG1733 766760010890 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 766760010891 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 766760010892 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 766760010893 putative active site [active] 766760010894 putative FMN binding site [chemical binding]; other site 766760010895 putative substrate binding site [chemical binding]; other site 766760010896 putative catalytic residue [active] 766760010897 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 766760010898 active site 766760010899 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 766760010900 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 766760010901 substrate binding [chemical binding]; other site 766760010902 active site 766760010903 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 766760010904 Clp protease; Region: CLP_protease; pfam00574 766760010905 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 766760010906 oligomer interface [polypeptide binding]; other site 766760010907 active site residues [active] 766760010908 TIGR00730 family protein; Region: TIGR00730 766760010909 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 766760010910 metal binding site [ion binding]; metal-binding site 766760010911 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 766760010912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760010913 Zn2+ binding site [ion binding]; other site 766760010914 Mg2+ binding site [ion binding]; other site 766760010915 putative transporter; Provisional; Region: PRK11660 766760010916 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 766760010917 Sulfate transporter family; Region: Sulfate_transp; pfam00916 766760010918 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 766760010919 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 766760010920 active site clefts [active] 766760010921 zinc binding site [ion binding]; other site 766760010922 dimer interface [polypeptide binding]; other site 766760010923 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 766760010924 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 766760010925 dimerization interface [polypeptide binding]; other site 766760010926 ligand binding site [chemical binding]; other site 766760010927 NADP binding site [chemical binding]; other site 766760010928 catalytic site [active] 766760010929 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 766760010930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760010931 dimerization interface [polypeptide binding]; other site 766760010932 putative DNA binding site [nucleotide binding]; other site 766760010933 putative Zn2+ binding site [ion binding]; other site 766760010934 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 766760010935 active site 766760010936 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 766760010937 RNAase interaction site [polypeptide binding]; other site 766760010938 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 766760010939 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 766760010940 dimerization domain swap beta strand [polypeptide binding]; other site 766760010941 regulatory protein interface [polypeptide binding]; other site 766760010942 active site 766760010943 regulatory phosphorylation site [posttranslational modification]; other site 766760010944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 766760010945 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 766760010946 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 766760010947 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 766760010948 phosphate binding site [ion binding]; other site 766760010949 putative substrate binding pocket [chemical binding]; other site 766760010950 dimer interface [polypeptide binding]; other site 766760010951 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 766760010952 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 766760010953 putative active site [active] 766760010954 nucleotide binding site [chemical binding]; other site 766760010955 nudix motif; other site 766760010956 putative metal binding site [ion binding]; other site 766760010957 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 766760010958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760010959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760010960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760010961 binding surface 766760010962 TPR motif; other site 766760010963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760010964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760010965 Coenzyme A binding pocket [chemical binding]; other site 766760010966 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 766760010967 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 766760010968 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 766760010969 metal binding site [ion binding]; metal-binding site 766760010970 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 766760010971 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 766760010972 substrate binding site [chemical binding]; other site 766760010973 glutamase interaction surface [polypeptide binding]; other site 766760010974 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 766760010975 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 766760010976 catalytic residues [active] 766760010977 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 766760010978 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 766760010979 putative active site [active] 766760010980 oxyanion strand; other site 766760010981 catalytic triad [active] 766760010982 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 766760010983 putative active site pocket [active] 766760010984 4-fold oligomerization interface [polypeptide binding]; other site 766760010985 metal binding residues [ion binding]; metal-binding site 766760010986 3-fold/trimer interface [polypeptide binding]; other site 766760010987 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 766760010988 histidinol dehydrogenase; Region: hisD; TIGR00069 766760010989 NAD binding site [chemical binding]; other site 766760010990 dimerization interface [polypeptide binding]; other site 766760010991 product binding site; other site 766760010992 substrate binding site [chemical binding]; other site 766760010993 zinc binding site [ion binding]; other site 766760010994 catalytic residues [active] 766760010995 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 766760010996 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 766760010997 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 766760010998 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 766760010999 dimer interface [polypeptide binding]; other site 766760011000 motif 1; other site 766760011001 active site 766760011002 motif 2; other site 766760011003 motif 3; other site 766760011004 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 766760011005 putative active site [active] 766760011006 Pectate lyase; Region: Pectate_lyase; pfam03211 766760011007 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 766760011008 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 766760011009 trimer interface [polypeptide binding]; other site 766760011010 active site 766760011011 substrate binding site [chemical binding]; other site 766760011012 CoA binding site [chemical binding]; other site 766760011013 pyrophosphatase PpaX; Provisional; Region: PRK13288 766760011014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760011015 active site 766760011016 motif I; other site 766760011017 motif II; other site 766760011018 Nucleoside recognition; Region: Gate; pfam07670 766760011019 Nucleoside recognition; Region: Gate; pfam07670 766760011020 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 766760011021 HPr kinase/phosphorylase; Provisional; Region: PRK05428 766760011022 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 766760011023 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 766760011024 Hpr binding site; other site 766760011025 active site 766760011026 homohexamer subunit interaction site [polypeptide binding]; other site 766760011027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760011028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760011029 putative Zn2+ binding site [ion binding]; other site 766760011030 putative DNA binding site [nucleotide binding]; other site 766760011031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011032 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760011033 putative substrate translocation pore; other site 766760011034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011035 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 766760011036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 766760011037 putative active site [active] 766760011038 putative metal binding site [ion binding]; other site 766760011039 Predicted membrane protein [Function unknown]; Region: COG1950 766760011040 PspC domain; Region: PspC; pfam04024 766760011041 Uncharacterized conserved protein [Function unknown]; Region: COG3595 766760011042 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 766760011043 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 766760011044 dimer interface [polypeptide binding]; other site 766760011045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760011046 metal binding site [ion binding]; metal-binding site 766760011047 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 766760011048 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 766760011049 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 766760011050 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 766760011051 excinuclease ABC subunit B; Provisional; Region: PRK05298 766760011052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760011053 ATP binding site [chemical binding]; other site 766760011054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760011055 nucleotide binding region [chemical binding]; other site 766760011056 ATP-binding site [chemical binding]; other site 766760011057 Ultra-violet resistance protein B; Region: UvrB; pfam12344 766760011058 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 766760011059 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 766760011060 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 766760011061 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 766760011062 C-terminal peptidase (prc); Region: prc; TIGR00225 766760011063 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 766760011064 protein binding site [polypeptide binding]; other site 766760011065 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 766760011066 Catalytic dyad [active] 766760011067 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 766760011068 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 766760011069 tartrate dehydrogenase; Provisional; Region: PRK08194 766760011070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 766760011071 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 766760011072 Peptidase family M23; Region: Peptidase_M23; pfam01551 766760011073 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 766760011074 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 766760011075 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 766760011076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760011077 Walker A/P-loop; other site 766760011078 ATP binding site [chemical binding]; other site 766760011079 Q-loop/lid; other site 766760011080 ABC transporter signature motif; other site 766760011081 Walker B; other site 766760011082 D-loop; other site 766760011083 H-loop/switch region; other site 766760011084 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 766760011085 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 766760011086 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760011087 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760011088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760011089 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760011090 peptide chain release factor 2; Provisional; Region: PRK06746 766760011091 This domain is found in peptide chain release factors; Region: PCRF; smart00937 766760011092 RF-1 domain; Region: RF-1; pfam00472 766760011093 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 766760011094 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 766760011095 nucleotide binding region [chemical binding]; other site 766760011096 helicase superfamily c-terminal domain; Region: HELICc; smart00490 766760011097 ATP-binding site [chemical binding]; other site 766760011098 SEC-C motif; Region: SEC-C; pfam02810 766760011099 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 766760011100 30S subunit binding site; other site 766760011101 Flagellar protein FliT; Region: FliT; cl05125 766760011102 flagellar protein FliS; Validated; Region: fliS; PRK05685 766760011103 flagellar capping protein; Validated; Region: fliD; PRK07737 766760011104 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 766760011105 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 766760011106 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 766760011107 flagellar protein FlaG; Provisional; Region: PRK07738 766760011108 flagellin; Provisional; Region: PRK12804 766760011109 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 766760011110 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 766760011111 carbon storage regulator; Provisional; Region: PRK01712 766760011112 flagellar assembly protein FliW; Provisional; Region: PRK13285 766760011113 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 766760011114 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 766760011115 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 766760011116 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 766760011117 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 766760011118 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 766760011119 FlgN protein; Region: FlgN; pfam05130 766760011120 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 766760011121 flagellar operon protein TIGR03826; Region: YvyF 766760011122 comF family protein; Region: comF; TIGR00201 766760011123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760011124 active site 766760011125 Late competence development protein ComFB; Region: ComFB; pfam10719 766760011126 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 766760011127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760011128 ATP binding site [chemical binding]; other site 766760011129 putative Mg++ binding site [ion binding]; other site 766760011130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760011131 nucleotide binding region [chemical binding]; other site 766760011132 ATP-binding site [chemical binding]; other site 766760011133 EDD domain protein, DegV family; Region: DegV; TIGR00762 766760011134 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 766760011135 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760011136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760011137 active site 766760011138 phosphorylation site [posttranslational modification] 766760011139 intermolecular recognition site; other site 766760011140 dimerization interface [polypeptide binding]; other site 766760011141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760011142 DNA binding residues [nucleotide binding] 766760011143 dimerization interface [polypeptide binding]; other site 766760011144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760011145 Histidine kinase; Region: HisKA_3; pfam07730 766760011146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760011147 ATP binding site [chemical binding]; other site 766760011148 Mg2+ binding site [ion binding]; other site 766760011149 G-X-G motif; other site 766760011150 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 766760011151 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 766760011152 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 766760011153 Transcriptional regulator [Transcription]; Region: LytR; COG1316 766760011154 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 766760011155 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 766760011156 Mg++ binding site [ion binding]; other site 766760011157 putative catalytic motif [active] 766760011158 substrate binding site [chemical binding]; other site 766760011159 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 766760011160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760011161 putative homodimer interface [polypeptide binding]; other site 766760011162 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 766760011163 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 766760011164 active site 766760011165 O-Antigen ligase; Region: Wzy_C; pfam04932 766760011166 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 766760011167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760011168 NAD(P) binding site [chemical binding]; other site 766760011169 active site 766760011170 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 766760011171 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 766760011172 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 766760011173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760011174 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 766760011175 colanic acid exporter; Provisional; Region: PRK10459 766760011176 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 766760011177 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 766760011178 Bacterial sugar transferase; Region: Bac_transf; pfam02397 766760011179 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760011180 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 766760011181 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760011182 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760011183 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 766760011184 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 766760011185 active site 766760011186 metal binding site [ion binding]; metal-binding site 766760011187 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760011188 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 766760011189 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760011190 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 766760011191 Stage II sporulation protein; Region: SpoIID; pfam08486 766760011192 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 766760011193 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 766760011194 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 766760011195 Homeodomain-like domain; Region: HTH_23; cl17451 766760011196 HTH-like domain; Region: HTH_21; pfam13276 766760011197 Integrase core domain; Region: rve; pfam00665 766760011198 Integrase core domain; Region: rve_3; cl15866 766760011199 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 766760011200 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 766760011201 active site 766760011202 homodimer interface [polypeptide binding]; other site 766760011203 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 766760011204 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 766760011205 active site 766760011206 tetramer interface; other site 766760011207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760011208 D-loop; other site 766760011209 H-loop/switch region; other site 766760011210 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 766760011211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760011212 Walker A/P-loop; other site 766760011213 ATP binding site [chemical binding]; other site 766760011214 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 766760011215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 766760011216 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 766760011217 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 766760011218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 766760011219 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 766760011220 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 766760011221 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 766760011222 Walker A/P-loop; other site 766760011223 ATP binding site [chemical binding]; other site 766760011224 Q-loop/lid; other site 766760011225 ABC transporter signature motif; other site 766760011226 Walker B; other site 766760011227 D-loop; other site 766760011228 H-loop/switch region; other site 766760011229 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 766760011230 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 766760011231 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 766760011232 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 766760011233 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 766760011234 putative ADP-binding pocket [chemical binding]; other site 766760011235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 766760011236 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 766760011237 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 766760011238 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 766760011239 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 766760011240 active site 766760011241 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 766760011242 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 766760011243 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 766760011244 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 766760011245 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 766760011246 Bacterial SH3 domain; Region: SH3_3; pfam08239 766760011247 Lysozyme subfamily 2; Region: LYZ2; smart00047 766760011248 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 766760011249 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 766760011250 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 766760011251 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 766760011252 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 766760011253 Class III ribonucleotide reductase; Region: RNR_III; cd01675 766760011254 effector binding site; other site 766760011255 active site 766760011256 Zn binding site [ion binding]; other site 766760011257 glycine loop; other site 766760011258 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 766760011259 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 766760011260 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 766760011261 active site 766760011262 intersubunit interface [polypeptide binding]; other site 766760011263 catalytic residue [active] 766760011264 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 766760011265 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 766760011266 substrate binding site [chemical binding]; other site 766760011267 ATP binding site [chemical binding]; other site 766760011268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760011269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760011270 DNA binding site [nucleotide binding] 766760011271 domain linker motif; other site 766760011272 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 766760011273 putative dimerization interface [polypeptide binding]; other site 766760011274 putative ligand binding site [chemical binding]; other site 766760011275 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 766760011276 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 766760011277 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 766760011278 NADP binding site [chemical binding]; other site 766760011279 homodimer interface [polypeptide binding]; other site 766760011280 active site 766760011281 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 766760011282 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 766760011283 NAD binding site [chemical binding]; other site 766760011284 catalytic Zn binding site [ion binding]; other site 766760011285 structural Zn binding site [ion binding]; other site 766760011286 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 766760011287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011288 putative substrate translocation pore; other site 766760011289 Transcriptional regulator [Transcription]; Region: LytR; COG1316 766760011290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760011291 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 766760011292 active site 766760011293 motif I; other site 766760011294 motif II; other site 766760011295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760011296 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760011297 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760011298 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760011299 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760011300 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 766760011301 NlpC/P60 family; Region: NLPC_P60; pfam00877 766760011302 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 766760011303 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 766760011304 putative active site [active] 766760011305 putative metal binding site [ion binding]; other site 766760011306 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 766760011307 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 766760011308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 766760011309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760011310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760011311 DNA binding site [nucleotide binding] 766760011312 domain linker motif; other site 766760011313 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 766760011314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 766760011315 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 766760011316 substrate binding site [chemical binding]; other site 766760011317 dimer interface [polypeptide binding]; other site 766760011318 ATP binding site [chemical binding]; other site 766760011319 D-ribose pyranase; Provisional; Region: PRK11797 766760011320 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 766760011321 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 766760011322 Walker A/P-loop; other site 766760011323 ATP binding site [chemical binding]; other site 766760011324 Q-loop/lid; other site 766760011325 ABC transporter signature motif; other site 766760011326 Walker B; other site 766760011327 D-loop; other site 766760011328 H-loop/switch region; other site 766760011329 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 766760011330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 766760011331 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 766760011332 TM-ABC transporter signature motif; other site 766760011333 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 766760011334 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 766760011335 ligand binding site [chemical binding]; other site 766760011336 dimerization interface [polypeptide binding]; other site 766760011337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760011338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760011339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 766760011340 dimerization interface [polypeptide binding]; other site 766760011341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 766760011342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760011343 S-adenosylmethionine binding site [chemical binding]; other site 766760011344 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 766760011345 acetolactate synthase; Reviewed; Region: PRK08617 766760011346 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 766760011347 PYR/PP interface [polypeptide binding]; other site 766760011348 dimer interface [polypeptide binding]; other site 766760011349 TPP binding site [chemical binding]; other site 766760011350 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 766760011351 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 766760011352 TPP-binding site [chemical binding]; other site 766760011353 dimer interface [polypeptide binding]; other site 766760011354 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 766760011355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760011356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 766760011357 dimerization interface [polypeptide binding]; other site 766760011358 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 766760011359 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 766760011360 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 766760011361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 766760011362 putative DNA binding site [nucleotide binding]; other site 766760011363 putative Zn2+ binding site [ion binding]; other site 766760011364 AsnC family; Region: AsnC_trans_reg; pfam01037 766760011365 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 766760011366 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 766760011367 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 766760011368 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 766760011369 Chain length determinant protein; Region: Wzz; cl15801 766760011370 SNF2 Helicase protein; Region: DUF3670; pfam12419 766760011371 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 766760011372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 766760011373 ATP binding site [chemical binding]; other site 766760011374 putative Mg++ binding site [ion binding]; other site 766760011375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760011376 nucleotide binding region [chemical binding]; other site 766760011377 ATP-binding site [chemical binding]; other site 766760011378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 766760011379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 766760011380 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 766760011381 Walker A motif; other site 766760011382 ATP binding site [chemical binding]; other site 766760011383 Walker B motif; other site 766760011384 arginine finger; other site 766760011385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 766760011386 binding surface 766760011387 Tetratricopeptide repeat; Region: TPR_16; pfam13432 766760011388 TPR motif; other site 766760011389 Tetratricopeptide repeat; Region: TPR_16; pfam13432 766760011390 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 766760011391 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 766760011392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760011393 active site 766760011394 motif I; other site 766760011395 motif II; other site 766760011396 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 766760011397 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 766760011398 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 766760011399 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 766760011400 Class I aldolases; Region: Aldolase_Class_I; cl17187 766760011401 catalytic residue [active] 766760011402 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 766760011403 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 766760011404 putative NAD(P) binding site [chemical binding]; other site 766760011405 active site 766760011406 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 766760011407 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 766760011408 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 766760011409 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 766760011410 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 766760011411 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 766760011412 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 766760011413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 766760011414 non-specific DNA interactions [nucleotide binding]; other site 766760011415 DNA binding site [nucleotide binding] 766760011416 sequence specific DNA binding site [nucleotide binding]; other site 766760011417 putative cAMP binding site [chemical binding]; other site 766760011418 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 766760011419 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 766760011420 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 766760011421 dimer interface [polypeptide binding]; other site 766760011422 ssDNA binding site [nucleotide binding]; other site 766760011423 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760011424 YwpF-like protein; Region: YwpF; pfam14183 766760011425 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 766760011426 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 766760011427 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 766760011428 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 766760011429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 766760011430 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 766760011431 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 766760011432 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 766760011433 rod shape-determining protein Mbl; Provisional; Region: PRK13928 766760011434 MreB and similar proteins; Region: MreB_like; cd10225 766760011435 nucleotide binding site [chemical binding]; other site 766760011436 Mg binding site [ion binding]; other site 766760011437 putative protofilament interaction site [polypeptide binding]; other site 766760011438 RodZ interaction site [polypeptide binding]; other site 766760011439 Stage III sporulation protein D; Region: SpoIIID; pfam12116 766760011440 Transcriptional regulators [Transcription]; Region: MarR; COG1846 766760011441 MarR family; Region: MarR; pfam01047 766760011442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760011443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011444 putative substrate translocation pore; other site 766760011445 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 766760011446 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 766760011447 active site 766760011448 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 766760011449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 766760011450 DHHA2 domain; Region: DHHA2; pfam02833 766760011451 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 766760011452 dimanganese center [ion binding]; other site 766760011453 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 766760011454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 766760011455 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 766760011456 putative NAD(P) binding site [chemical binding]; other site 766760011457 putative active site [active] 766760011458 FOG: CBS domain [General function prediction only]; Region: COG0517 766760011459 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 766760011460 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 766760011461 Cl binding site [ion binding]; other site 766760011462 oligomer interface [polypeptide binding]; other site 766760011463 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 766760011464 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 766760011465 Domain of unknown function DUF21; Region: DUF21; pfam01595 766760011466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 766760011467 Transporter associated domain; Region: CorC_HlyC; smart01091 766760011468 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 766760011469 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 766760011470 Nitrogen regulatory protein P-II; Region: P-II; smart00938 766760011471 Clp protease; Region: CLP_protease; pfam00574 766760011472 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 766760011473 oligomer interface [polypeptide binding]; other site 766760011474 active site residues [active] 766760011475 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 766760011476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760011477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760011478 DNA binding residues [nucleotide binding] 766760011479 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 766760011480 Peptidase family M23; Region: Peptidase_M23; pfam01551 766760011481 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 766760011482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760011483 Coenzyme A binding pocket [chemical binding]; other site 766760011484 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 766760011485 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 766760011486 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 766760011487 putative active site [active] 766760011488 catalytic site [active] 766760011489 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 766760011490 putative active site [active] 766760011491 catalytic site [active] 766760011492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760011494 putative substrate translocation pore; other site 766760011495 Condensation domain; Region: Condensation; pfam00668 766760011496 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760011497 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 766760011498 acyl-activating enzyme (AAE) consensus motif; other site 766760011499 AMP binding site [chemical binding]; other site 766760011500 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760011501 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 766760011502 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 766760011503 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 766760011504 acyl-activating enzyme (AAE) consensus motif; other site 766760011505 AMP binding site [chemical binding]; other site 766760011506 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 766760011507 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 766760011508 Isochorismatase family; Region: Isochorismatase; pfam00857 766760011509 catalytic triad [active] 766760011510 conserved cis-peptide bond; other site 766760011511 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 766760011512 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 766760011513 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 766760011514 acyl-activating enzyme (AAE) consensus motif; other site 766760011515 active site 766760011516 AMP binding site [chemical binding]; other site 766760011517 substrate binding site [chemical binding]; other site 766760011518 isochorismate synthase DhbC; Validated; Region: PRK06923 766760011519 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 766760011520 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 766760011521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760011522 NAD(P) binding site [chemical binding]; other site 766760011523 active site 766760011524 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 766760011525 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 766760011526 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760011527 ABC-ATPase subunit interface; other site 766760011528 dimer interface [polypeptide binding]; other site 766760011529 putative PBP binding regions; other site 766760011530 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 766760011531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760011532 ABC-ATPase subunit interface; other site 766760011533 dimer interface [polypeptide binding]; other site 766760011534 putative PBP binding regions; other site 766760011535 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760011536 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 766760011537 intersubunit interface [polypeptide binding]; other site 766760011538 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 766760011539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 766760011540 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 766760011541 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 766760011542 intersubunit interface [polypeptide binding]; other site 766760011543 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 766760011544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760011545 Coenzyme A binding pocket [chemical binding]; other site 766760011546 Predicted transcriptional regulator [Transcription]; Region: COG1959 766760011547 Transcriptional regulator; Region: Rrf2; pfam02082 766760011548 GRAM domain; Region: GRAM; pfam02893 766760011549 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 766760011550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 766760011551 FeS/SAM binding site; other site 766760011552 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 766760011553 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 766760011554 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 766760011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011556 putative substrate translocation pore; other site 766760011557 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 766760011558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 766760011559 molybdopterin cofactor binding site; other site 766760011560 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 766760011561 molybdopterin cofactor binding site; other site 766760011562 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 766760011563 metal ion-dependent adhesion site (MIDAS); other site 766760011564 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 766760011565 metal ion-dependent adhesion site (MIDAS); other site 766760011566 Stage II sporulation protein; Region: SpoIID; pfam08486 766760011567 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 766760011568 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 766760011569 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 766760011570 hinge; other site 766760011571 active site 766760011572 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 766760011573 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 766760011574 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 766760011575 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 766760011576 gamma subunit interface [polypeptide binding]; other site 766760011577 epsilon subunit interface [polypeptide binding]; other site 766760011578 LBP interface [polypeptide binding]; other site 766760011579 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 766760011580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 766760011581 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 766760011582 alpha subunit interaction interface [polypeptide binding]; other site 766760011583 Walker A motif; other site 766760011584 ATP binding site [chemical binding]; other site 766760011585 Walker B motif; other site 766760011586 inhibitor binding site; inhibition site 766760011587 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 766760011588 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 766760011589 core domain interface [polypeptide binding]; other site 766760011590 delta subunit interface [polypeptide binding]; other site 766760011591 epsilon subunit interface [polypeptide binding]; other site 766760011592 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 766760011593 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 766760011594 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 766760011595 beta subunit interaction interface [polypeptide binding]; other site 766760011596 Walker A motif; other site 766760011597 ATP binding site [chemical binding]; other site 766760011598 Walker B motif; other site 766760011599 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 766760011600 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 766760011601 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 766760011602 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 766760011603 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 766760011604 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 766760011605 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 766760011606 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 766760011607 ATP synthase I chain; Region: ATP_synt_I; pfam03899 766760011608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 766760011609 active site 766760011610 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 766760011611 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 766760011612 dimer interface [polypeptide binding]; other site 766760011613 active site 766760011614 glycine-pyridoxal phosphate binding site [chemical binding]; other site 766760011615 folate binding site [chemical binding]; other site 766760011616 hypothetical protein; Provisional; Region: PRK13690 766760011617 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 766760011618 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 766760011619 Low molecular weight phosphatase family; Region: LMWPc; cd00115 766760011620 active site 766760011621 Predicted membrane protein [Function unknown]; Region: COG1971 766760011622 Domain of unknown function DUF; Region: DUF204; pfam02659 766760011623 Domain of unknown function DUF; Region: DUF204; pfam02659 766760011624 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 766760011625 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 766760011626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 766760011627 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 766760011628 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 766760011629 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760011630 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760011631 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 766760011632 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 766760011633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760011634 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 766760011635 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 766760011636 inhibitor-cofactor binding pocket; inhibition site 766760011637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760011638 catalytic residue [active] 766760011639 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760011640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760011641 DNA binding site [nucleotide binding] 766760011642 domain linker motif; other site 766760011643 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 766760011644 putative ligand binding site [chemical binding]; other site 766760011645 putative dimerization interface [polypeptide binding]; other site 766760011646 Integrase core domain; Region: rve_3; cl15866 766760011647 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 766760011648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760011649 S-adenosylmethionine binding site [chemical binding]; other site 766760011650 peptide chain release factor 1; Validated; Region: prfA; PRK00591 766760011651 This domain is found in peptide chain release factors; Region: PCRF; smart00937 766760011652 RF-1 domain; Region: RF-1; pfam00472 766760011653 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 766760011654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760011655 putative metal binding site [ion binding]; other site 766760011656 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 766760011657 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 766760011658 DNA binding residues [nucleotide binding] 766760011659 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 766760011660 malate dehydrogenase; Provisional; Region: PRK13529 766760011661 Malic enzyme, N-terminal domain; Region: malic; pfam00390 766760011662 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 766760011663 NAD(P) binding site [chemical binding]; other site 766760011664 thymidine kinase; Provisional; Region: PRK04296 766760011665 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 766760011666 transcription termination factor Rho; Provisional; Region: rho; PRK09376 766760011667 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 766760011668 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 766760011669 RNA binding site [nucleotide binding]; other site 766760011670 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 766760011671 multimer interface [polypeptide binding]; other site 766760011672 Walker A motif; other site 766760011673 ATP binding site [chemical binding]; other site 766760011674 Walker B motif; other site 766760011675 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 766760011676 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 766760011677 putative active site [active] 766760011678 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 766760011679 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 766760011680 hinge; other site 766760011681 active site 766760011682 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 766760011683 active site 766760011684 intersubunit interactions; other site 766760011685 catalytic residue [active] 766760011686 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 766760011687 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 766760011688 intersubunit interface [polypeptide binding]; other site 766760011689 active site 766760011690 zinc binding site [ion binding]; other site 766760011691 Na+ binding site [ion binding]; other site 766760011692 Response regulator receiver domain; Region: Response_reg; pfam00072 766760011693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760011694 active site 766760011695 phosphorylation site [posttranslational modification] 766760011696 intermolecular recognition site; other site 766760011697 dimerization interface [polypeptide binding]; other site 766760011698 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 766760011699 CTP synthetase; Validated; Region: pyrG; PRK05380 766760011700 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 766760011701 Catalytic site [active] 766760011702 active site 766760011703 UTP binding site [chemical binding]; other site 766760011704 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 766760011705 active site 766760011706 putative oxyanion hole; other site 766760011707 catalytic triad [active] 766760011708 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 766760011709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 766760011710 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 766760011711 FAD binding site [chemical binding]; other site 766760011712 homotetramer interface [polypeptide binding]; other site 766760011713 substrate binding pocket [chemical binding]; other site 766760011714 catalytic base [active] 766760011715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 766760011716 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 766760011717 FAD binding site [chemical binding]; other site 766760011718 homotetramer interface [polypeptide binding]; other site 766760011719 substrate binding pocket [chemical binding]; other site 766760011720 catalytic base [active] 766760011721 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 766760011722 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 766760011723 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 766760011724 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 766760011725 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 766760011726 dimer interface [polypeptide binding]; other site 766760011727 active site 766760011728 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 766760011729 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 766760011730 4Fe-4S binding domain; Region: Fer4; cl02805 766760011731 Cysteine-rich domain; Region: CCG; pfam02754 766760011732 Cysteine-rich domain; Region: CCG; pfam02754 766760011733 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 766760011734 PLD-like domain; Region: PLDc_2; pfam13091 766760011735 putative active site [active] 766760011736 catalytic site [active] 766760011737 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 766760011738 PLD-like domain; Region: PLDc_2; pfam13091 766760011739 putative active site [active] 766760011740 catalytic site [active] 766760011741 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 766760011742 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 766760011743 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 766760011744 active site 766760011745 HIGH motif; other site 766760011746 KMSK motif region; other site 766760011747 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 766760011748 tRNA binding surface [nucleotide binding]; other site 766760011749 anticodon binding site; other site 766760011750 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 766760011751 agmatinase; Region: agmatinase; TIGR01230 766760011752 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 766760011753 putative active site [active] 766760011754 Mn binding site [ion binding]; other site 766760011755 spermidine synthase; Provisional; Region: PRK00811 766760011756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760011757 Transglycosylase; Region: Transgly; pfam00912 766760011758 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 766760011759 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 766760011760 YwhD family; Region: YwhD; pfam08741 766760011761 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 766760011762 Peptidase family M50; Region: Peptidase_M50; pfam02163 766760011763 active site 766760011764 putative substrate binding region [chemical binding]; other site 766760011765 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 766760011766 active site 1 [active] 766760011767 dimer interface [polypeptide binding]; other site 766760011768 hexamer interface [polypeptide binding]; other site 766760011769 active site 2 [active] 766760011770 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 766760011771 active site 766760011772 Uncharacterized conserved protein [Function unknown]; Region: COG3465 766760011773 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 766760011774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 766760011775 Zn2+ binding site [ion binding]; other site 766760011776 Mg2+ binding site [ion binding]; other site 766760011777 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 766760011778 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 766760011779 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 766760011780 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 766760011781 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 766760011782 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 766760011783 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 766760011784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 766760011785 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 766760011786 benzoate transport; Region: 2A0115; TIGR00895 766760011787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011788 putative substrate translocation pore; other site 766760011789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760011790 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 766760011791 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 766760011792 active site 766760011793 metal binding site [ion binding]; metal-binding site 766760011794 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 766760011795 active site 1 [active] 766760011796 dimer interface [polypeptide binding]; other site 766760011797 hexamer interface [polypeptide binding]; other site 766760011798 active site 2 [active] 766760011799 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 766760011800 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 766760011801 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 766760011802 NAD binding site [chemical binding]; other site 766760011803 catalytic residues [active] 766760011804 Transcriptional regulator [Transcription]; Region: IclR; COG1414 766760011805 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 766760011806 Bacterial transcriptional regulator; Region: IclR; pfam01614 766760011807 Amidohydrolase; Region: Amidohydro_2; pfam04909 766760011808 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 766760011809 putative heme peroxidase; Provisional; Region: PRK12276 766760011810 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 766760011811 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 766760011812 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 766760011813 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 766760011814 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 766760011815 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 766760011816 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 766760011817 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 766760011818 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760011819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760011820 Walker A/P-loop; other site 766760011821 ATP binding site [chemical binding]; other site 766760011822 Q-loop/lid; other site 766760011823 ABC transporter signature motif; other site 766760011824 Walker B; other site 766760011825 D-loop; other site 766760011826 H-loop/switch region; other site 766760011827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760011828 Histidine kinase; Region: HisKA_3; pfam07730 766760011829 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 766760011830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760011831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760011832 active site 766760011833 phosphorylation site [posttranslational modification] 766760011834 intermolecular recognition site; other site 766760011835 dimerization interface [polypeptide binding]; other site 766760011836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760011837 DNA binding residues [nucleotide binding] 766760011838 dimerization interface [polypeptide binding]; other site 766760011839 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 766760011840 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 766760011841 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 766760011842 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 766760011843 NAD(P) binding site [chemical binding]; other site 766760011844 catalytic residues [active] 766760011845 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 766760011846 ligand binding site [chemical binding]; other site 766760011847 active site 766760011848 UGI interface [polypeptide binding]; other site 766760011849 catalytic site [active] 766760011850 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 766760011851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 766760011852 active site 766760011853 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 766760011854 dimer interface [polypeptide binding]; other site 766760011855 substrate binding site [chemical binding]; other site 766760011856 ATP binding site [chemical binding]; other site 766760011857 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 766760011858 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 766760011859 substrate binding [chemical binding]; other site 766760011860 active site 766760011861 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 766760011862 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 766760011863 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760011864 active site turn [active] 766760011865 phosphorylation site [posttranslational modification] 766760011866 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760011867 transcriptional antiterminator BglG; Provisional; Region: PRK09772 766760011868 CAT RNA binding domain; Region: CAT_RBD; smart01061 766760011869 PRD domain; Region: PRD; pfam00874 766760011870 PRD domain; Region: PRD; pfam00874 766760011871 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 766760011872 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 766760011873 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 766760011874 putative active site [active] 766760011875 catalytic triad [active] 766760011876 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 766760011877 PA/protease domain interface [polypeptide binding]; other site 766760011878 putative integrin binding motif; other site 766760011879 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 766760011880 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 766760011881 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 766760011882 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 766760011883 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 766760011884 dimer interface [polypeptide binding]; other site 766760011885 FMN binding site [chemical binding]; other site 766760011886 NADPH bind site [chemical binding]; other site 766760011887 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 766760011888 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 766760011889 metal binding site [ion binding]; metal-binding site 766760011890 dimer interface [polypeptide binding]; other site 766760011891 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 766760011892 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 766760011893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 766760011894 Nucleoside recognition; Region: Gate; pfam07670 766760011895 Clostripain family; Region: Peptidase_C11; pfam03415 766760011896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760011897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760011898 Coenzyme A binding pocket [chemical binding]; other site 766760011899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760011900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760011901 Walker A/P-loop; other site 766760011902 ATP binding site [chemical binding]; other site 766760011903 Q-loop/lid; other site 766760011904 ABC transporter signature motif; other site 766760011905 Walker B; other site 766760011906 D-loop; other site 766760011907 H-loop/switch region; other site 766760011908 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760011909 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760011910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760011911 Walker A/P-loop; other site 766760011912 ATP binding site [chemical binding]; other site 766760011913 Q-loop/lid; other site 766760011914 ABC transporter signature motif; other site 766760011915 Walker B; other site 766760011916 D-loop; other site 766760011917 H-loop/switch region; other site 766760011918 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 766760011919 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 766760011920 Ligand Binding Site [chemical binding]; other site 766760011921 Molecular Tunnel; other site 766760011922 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 766760011923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760011924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760011925 active site 766760011926 phosphorylation site [posttranslational modification] 766760011927 intermolecular recognition site; other site 766760011928 dimerization interface [polypeptide binding]; other site 766760011929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760011930 DNA binding residues [nucleotide binding] 766760011931 dimerization interface [polypeptide binding]; other site 766760011932 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 766760011933 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 766760011934 Subunit I/III interface [polypeptide binding]; other site 766760011935 Subunit III/IV interface [polypeptide binding]; other site 766760011936 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 766760011937 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 766760011938 D-pathway; other site 766760011939 Putative ubiquinol binding site [chemical binding]; other site 766760011940 Low-spin heme (heme b) binding site [chemical binding]; other site 766760011941 Putative water exit pathway; other site 766760011942 Binuclear center (heme o3/CuB) [ion binding]; other site 766760011943 K-pathway; other site 766760011944 Putative proton exit pathway; other site 766760011945 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 766760011946 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 766760011947 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 766760011948 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 766760011949 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 766760011950 NAD binding site [chemical binding]; other site 766760011951 homodimer interface [polypeptide binding]; other site 766760011952 active site 766760011953 substrate binding site [chemical binding]; other site 766760011954 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 766760011955 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 766760011956 Protein of unknown function, DUF485; Region: DUF485; pfam04341 766760011957 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 766760011958 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 766760011959 Na binding site [ion binding]; other site 766760011960 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 766760011961 N- and C-terminal domain interface [polypeptide binding]; other site 766760011962 D-xylulose kinase; Region: XylB; TIGR01312 766760011963 active site 766760011964 MgATP binding site [chemical binding]; other site 766760011965 catalytic site [active] 766760011966 metal binding site [ion binding]; metal-binding site 766760011967 xylulose binding site [chemical binding]; other site 766760011968 homodimer interface [polypeptide binding]; other site 766760011969 xylose isomerase; Provisional; Region: PRK05474 766760011970 xylose isomerase; Region: xylose_isom_A; TIGR02630 766760011971 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 766760011972 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 766760011973 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 766760011974 nucleotide binding site [chemical binding]; other site 766760011975 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 766760011976 thiamine phosphate binding site [chemical binding]; other site 766760011977 active site 766760011978 pyrophosphate binding site [ion binding]; other site 766760011979 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 766760011980 substrate binding site [chemical binding]; other site 766760011981 multimerization interface [polypeptide binding]; other site 766760011982 ATP binding site [chemical binding]; other site 766760011983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 766760011984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 766760011985 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 766760011986 putative dimerization interface [polypeptide binding]; other site 766760011987 holin-like protein; Validated; Region: PRK01658 766760011988 LrgB-like family; Region: LrgB; cl00596 766760011989 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 766760011990 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 766760011991 Na binding site [ion binding]; other site 766760011992 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 766760011993 PUA domain; Region: PUA; cl00607 766760011994 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 766760011995 putative RNA binding site [nucleotide binding]; other site 766760011996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760011997 S-adenosylmethionine binding site [chemical binding]; other site 766760011998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760011999 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 766760012000 active site 766760012001 metal binding site [ion binding]; metal-binding site 766760012002 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 766760012003 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 766760012004 putative ligand binding site [chemical binding]; other site 766760012005 putative NAD binding site [chemical binding]; other site 766760012006 catalytic site [active] 766760012007 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 766760012008 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 766760012009 Ligand binding site; other site 766760012010 metal-binding site 766760012011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760012012 Histidine kinase; Region: HisKA_3; pfam07730 766760012013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760012014 ATP binding site [chemical binding]; other site 766760012015 Mg2+ binding site [ion binding]; other site 766760012016 G-X-G motif; other site 766760012017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760012018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760012019 active site 766760012020 phosphorylation site [posttranslational modification] 766760012021 intermolecular recognition site; other site 766760012022 dimerization interface [polypeptide binding]; other site 766760012023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760012024 DNA binding residues [nucleotide binding] 766760012025 dimerization interface [polypeptide binding]; other site 766760012026 MMPL family; Region: MMPL; pfam03176 766760012027 MMPL family; Region: MMPL; pfam03176 766760012028 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 766760012029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012030 D-galactonate transporter; Region: 2A0114; TIGR00893 766760012031 putative substrate translocation pore; other site 766760012032 galactonate dehydratase; Provisional; Region: PRK14017 766760012033 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 766760012034 putative active site pocket [active] 766760012035 putative metal binding site [ion binding]; other site 766760012036 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 766760012037 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 766760012038 active site 766760012039 intersubunit interface [polypeptide binding]; other site 766760012040 catalytic residue [active] 766760012041 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 766760012042 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 766760012043 substrate binding site [chemical binding]; other site 766760012044 ATP binding site [chemical binding]; other site 766760012045 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 766760012046 Transcriptional regulator [Transcription]; Region: IclR; COG1414 766760012047 Bacterial transcriptional regulator; Region: IclR; pfam01614 766760012048 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 766760012049 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 766760012050 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 766760012051 PA/protease domain interface [polypeptide binding]; other site 766760012052 putative integrin binding motif; other site 766760012053 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 766760012054 metal binding site [ion binding]; metal-binding site 766760012055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760012057 putative substrate translocation pore; other site 766760012058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012059 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 766760012060 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 766760012061 synthetase active site [active] 766760012062 NTP binding site [chemical binding]; other site 766760012063 metal binding site [ion binding]; metal-binding site 766760012064 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 766760012065 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 766760012066 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 766760012067 acyl-activating enzyme (AAE) consensus motif; other site 766760012068 AMP binding site [chemical binding]; other site 766760012069 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 766760012070 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 766760012071 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 766760012072 DltD N-terminal region; Region: DltD_N; pfam04915 766760012073 DltD central region; Region: DltD_M; pfam04918 766760012074 DltD C-terminal region; Region: DltD_C; pfam04914 766760012075 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 766760012076 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 766760012077 homodimer interface [polypeptide binding]; other site 766760012078 substrate-cofactor binding pocket; other site 766760012079 catalytic residue [active] 766760012080 H+ Antiporter protein; Region: 2A0121; TIGR00900 766760012081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012082 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 766760012083 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 766760012084 NAD binding site [chemical binding]; other site 766760012085 sugar binding site [chemical binding]; other site 766760012086 divalent metal binding site [ion binding]; other site 766760012087 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760012088 dimer interface [polypeptide binding]; other site 766760012089 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 766760012090 methionine cluster; other site 766760012091 active site 766760012092 phosphorylation site [posttranslational modification] 766760012093 metal binding site [ion binding]; metal-binding site 766760012094 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 766760012095 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 766760012096 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 766760012097 active site 766760012098 P-loop; other site 766760012099 phosphorylation site [posttranslational modification] 766760012100 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 766760012101 HTH domain; Region: HTH_11; pfam08279 766760012102 Mga helix-turn-helix domain; Region: Mga; pfam05043 766760012103 PRD domain; Region: PRD; pfam00874 766760012104 PRD domain; Region: PRD; pfam00874 766760012105 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 766760012106 active site 766760012107 P-loop; other site 766760012108 phosphorylation site [posttranslational modification] 766760012109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 766760012110 active site 766760012111 phosphorylation site [posttranslational modification] 766760012112 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 766760012113 active site 766760012114 DNA binding site [nucleotide binding] 766760012115 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760012116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760012117 DNA-binding site [nucleotide binding]; DNA binding site 766760012118 FCD domain; Region: FCD; pfam07729 766760012119 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 766760012120 dimer interface [polypeptide binding]; other site 766760012121 Citrate synthase; Region: Citrate_synt; pfam00285 766760012122 active site 766760012123 coenzyme A binding site [chemical binding]; other site 766760012124 citrylCoA binding site [chemical binding]; other site 766760012125 oxalacetate/citrate binding site [chemical binding]; other site 766760012126 catalytic triad [active] 766760012127 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 766760012128 2-methylcitrate dehydratase; Region: prpD; TIGR02330 766760012129 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 766760012130 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 766760012131 tetramer interface [polypeptide binding]; other site 766760012132 active site 766760012133 Mg2+/Mn2+ binding site [ion binding]; other site 766760012134 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 766760012135 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 766760012136 Chromate transporter; Region: Chromate_transp; pfam02417 766760012137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760012138 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 766760012139 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 766760012140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760012141 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 766760012142 Walker A/P-loop; other site 766760012143 ATP binding site [chemical binding]; other site 766760012144 Q-loop/lid; other site 766760012145 ABC transporter signature motif; other site 766760012146 Walker B; other site 766760012147 D-loop; other site 766760012148 H-loop/switch region; other site 766760012149 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 766760012150 active site 766760012151 catalytic triad [active] 766760012152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012153 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 766760012154 putative substrate translocation pore; other site 766760012155 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 766760012156 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760012157 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760012158 Walker A/P-loop; other site 766760012159 ATP binding site [chemical binding]; other site 766760012160 Q-loop/lid; other site 766760012161 ABC transporter signature motif; other site 766760012162 Walker B; other site 766760012163 D-loop; other site 766760012164 H-loop/switch region; other site 766760012165 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 766760012166 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 766760012167 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 766760012168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760012169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760012170 DNA binding residues [nucleotide binding] 766760012171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 766760012173 putative substrate translocation pore; other site 766760012174 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 766760012175 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 766760012176 tetramer interface [polypeptide binding]; other site 766760012177 heme binding pocket [chemical binding]; other site 766760012178 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 766760012179 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 766760012180 tetramer interface [polypeptide binding]; other site 766760012181 heme binding pocket [chemical binding]; other site 766760012182 NADPH binding site [chemical binding]; other site 766760012183 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 766760012184 metal binding site 2 [ion binding]; metal-binding site 766760012185 putative DNA binding helix; other site 766760012186 metal binding site 1 [ion binding]; metal-binding site 766760012187 dimer interface [polypeptide binding]; other site 766760012188 structural Zn2+ binding site [ion binding]; other site 766760012189 ferrochelatase; Provisional; Region: PRK12435 766760012190 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 766760012191 C-terminal domain interface [polypeptide binding]; other site 766760012192 active site 766760012193 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 766760012194 active site 766760012195 N-terminal domain interface [polypeptide binding]; other site 766760012196 Amb_all domain; Region: Amb_all; smart00656 766760012197 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 766760012198 putative substrate binding site [chemical binding]; other site 766760012199 putative ATP binding site [chemical binding]; other site 766760012200 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 766760012201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760012202 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 766760012203 Walker A/P-loop; other site 766760012204 ATP binding site [chemical binding]; other site 766760012205 Q-loop/lid; other site 766760012206 ABC transporter signature motif; other site 766760012207 Walker B; other site 766760012208 D-loop; other site 766760012209 H-loop/switch region; other site 766760012210 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 766760012211 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 766760012212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 766760012213 Walker A/P-loop; other site 766760012214 ATP binding site [chemical binding]; other site 766760012215 Q-loop/lid; other site 766760012216 ABC transporter signature motif; other site 766760012217 Walker B; other site 766760012218 D-loop; other site 766760012219 H-loop/switch region; other site 766760012220 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 766760012221 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 766760012222 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 766760012223 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 766760012224 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 766760012225 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 766760012226 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 766760012227 Malic enzyme, N-terminal domain; Region: malic; pfam00390 766760012228 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 766760012229 NAD(P) binding pocket [chemical binding]; other site 766760012230 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 766760012231 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 766760012232 Aspartase; Region: Aspartase; cd01357 766760012233 active sites [active] 766760012234 tetramer interface [polypeptide binding]; other site 766760012235 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 766760012236 active site 766760012237 homodimer interface [polypeptide binding]; other site 766760012238 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 766760012239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 766760012240 non-specific DNA binding site [nucleotide binding]; other site 766760012241 salt bridge; other site 766760012242 sequence-specific DNA binding site [nucleotide binding]; other site 766760012243 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 766760012244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760012245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760012246 active site 766760012247 phosphorylation site [posttranslational modification] 766760012248 intermolecular recognition site; other site 766760012249 dimerization interface [polypeptide binding]; other site 766760012250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760012251 DNA binding site [nucleotide binding] 766760012252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760012253 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 766760012254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760012255 ATP binding site [chemical binding]; other site 766760012256 Mg2+ binding site [ion binding]; other site 766760012257 G-X-G motif; other site 766760012258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760012259 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760012260 Walker A/P-loop; other site 766760012261 ATP binding site [chemical binding]; other site 766760012262 Q-loop/lid; other site 766760012263 ABC transporter signature motif; other site 766760012264 Walker B; other site 766760012265 D-loop; other site 766760012266 H-loop/switch region; other site 766760012267 FtsX-like permease family; Region: FtsX; pfam02687 766760012268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 766760012269 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 766760012270 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 766760012271 putative active site [active] 766760012272 putative metal binding site [ion binding]; other site 766760012273 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 766760012274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760012275 DNA-binding site [nucleotide binding]; DNA binding site 766760012276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760012277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760012278 homodimer interface [polypeptide binding]; other site 766760012279 catalytic residue [active] 766760012280 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 766760012281 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 766760012282 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 766760012283 DXD motif; other site 766760012284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 766760012285 PilZ domain; Region: PilZ; pfam07238 766760012286 PilZ domain; Region: PilZ; pfam07238 766760012287 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 766760012288 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 766760012289 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 766760012290 active site 766760012291 catalytic site [active] 766760012292 Excalibur calcium-binding domain; Region: Excalibur; cl05460 766760012293 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 766760012294 Sulfatase; Region: Sulfatase; pfam00884 766760012295 Uncharacterized conserved protein [Function unknown]; Region: COG1284 766760012296 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760012297 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 766760012298 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 766760012299 Arginine repressor [Transcription]; Region: ArgR; COG1438 766760012300 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 766760012301 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 766760012302 arginine deiminase; Provisional; Region: PRK01388 766760012303 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 766760012304 ornithine carbamoyltransferase; Validated; Region: PRK02102 766760012305 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 766760012306 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 766760012307 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 766760012308 carbamate kinase; Reviewed; Region: PRK12686 766760012309 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 766760012310 putative substrate binding site [chemical binding]; other site 766760012311 nucleotide binding site [chemical binding]; other site 766760012312 nucleotide binding site [chemical binding]; other site 766760012313 homodimer interface [polypeptide binding]; other site 766760012314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 766760012315 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 766760012316 ligand binding site [chemical binding]; other site 766760012317 flexible hinge region; other site 766760012318 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 766760012319 putative switch regulator; other site 766760012320 non-specific DNA interactions [nucleotide binding]; other site 766760012321 DNA binding site [nucleotide binding] 766760012322 sequence specific DNA binding site [nucleotide binding]; other site 766760012323 putative cAMP binding site [chemical binding]; other site 766760012324 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 766760012325 beta-galactosidase; Region: BGL; TIGR03356 766760012326 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 766760012327 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 766760012328 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 766760012329 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 766760012330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760012331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760012332 DNA binding residues [nucleotide binding] 766760012333 peptidase T; Region: peptidase-T; TIGR01882 766760012334 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 766760012335 metal binding site [ion binding]; metal-binding site 766760012336 dimer interface [polypeptide binding]; other site 766760012337 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 766760012338 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 766760012339 substrate binding [chemical binding]; other site 766760012340 active site 766760012341 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 766760012342 galactoside permease; Reviewed; Region: lacY; PRK09528 766760012343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012344 putative substrate translocation pore; other site 766760012345 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760012346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760012347 dimer interface [polypeptide binding]; other site 766760012348 conserved gate region; other site 766760012349 putative PBP binding loops; other site 766760012350 ABC-ATPase subunit interface; other site 766760012351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760012352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760012353 dimer interface [polypeptide binding]; other site 766760012354 conserved gate region; other site 766760012355 putative PBP binding loops; other site 766760012356 ABC-ATPase subunit interface; other site 766760012357 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 766760012358 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760012359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760012360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760012361 DNA binding site [nucleotide binding] 766760012362 domain linker motif; other site 766760012363 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 766760012364 dimerization interface [polypeptide binding]; other site 766760012365 ligand binding site [chemical binding]; other site 766760012366 sodium binding site [ion binding]; other site 766760012367 Chorismate lyase; Region: Chor_lyase; cl01230 766760012368 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 766760012369 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 766760012370 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 766760012371 substrate binding site [chemical binding]; other site 766760012372 THF binding site; other site 766760012373 zinc-binding site [ion binding]; other site 766760012374 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 766760012375 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 766760012376 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 766760012377 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 766760012378 Ligand binding site; other site 766760012379 Putative Catalytic site; other site 766760012380 DXD motif; other site 766760012381 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 766760012382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 766760012383 NAD(P) binding site [chemical binding]; other site 766760012384 active site 766760012385 PGAP1-like protein; Region: PGAP1; pfam07819 766760012386 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 766760012387 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 766760012388 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 766760012389 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 766760012390 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 766760012391 hydroperoxidase II; Provisional; Region: katE; PRK11249 766760012392 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 766760012393 tetramer interface [polypeptide binding]; other site 766760012394 heme binding pocket [chemical binding]; other site 766760012395 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 766760012396 domain interactions; other site 766760012397 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 766760012398 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 766760012399 beta-galactosidase; Region: BGL; TIGR03356 766760012400 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 766760012401 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760012402 active site turn [active] 766760012403 phosphorylation site [posttranslational modification] 766760012404 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760012405 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 766760012406 HPr interaction site; other site 766760012407 glycerol kinase (GK) interaction site [polypeptide binding]; other site 766760012408 active site 766760012409 phosphorylation site [posttranslational modification] 766760012410 transcriptional antiterminator BglG; Provisional; Region: PRK09772 766760012411 CAT RNA binding domain; Region: CAT_RBD; smart01061 766760012412 PRD domain; Region: PRD; pfam00874 766760012413 PRD domain; Region: PRD; pfam00874 766760012414 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 766760012415 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 766760012416 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 766760012417 Walker A/P-loop; other site 766760012418 ATP binding site [chemical binding]; other site 766760012419 Q-loop/lid; other site 766760012420 ABC transporter signature motif; other site 766760012421 Walker B; other site 766760012422 D-loop; other site 766760012423 H-loop/switch region; other site 766760012424 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 766760012425 Walker A/P-loop; other site 766760012426 ATP binding site [chemical binding]; other site 766760012427 Q-loop/lid; other site 766760012428 ABC transporter signature motif; other site 766760012429 Walker B; other site 766760012430 D-loop; other site 766760012431 H-loop/switch region; other site 766760012432 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 766760012433 Putative transcription activator [Transcription]; Region: TenA; COG0819 766760012434 isocitrate lyase; Provisional; Region: PRK15063 766760012435 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 766760012436 tetramer interface [polypeptide binding]; other site 766760012437 active site 766760012438 Mg2+/Mn2+ binding site [ion binding]; other site 766760012439 malate synthase A; Region: malate_syn_A; TIGR01344 766760012440 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 766760012441 active site 766760012442 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 766760012443 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 766760012444 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 766760012445 FtsX-like permease family; Region: FtsX; pfam02687 766760012446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760012447 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760012448 Walker A/P-loop; other site 766760012449 ATP binding site [chemical binding]; other site 766760012450 Q-loop/lid; other site 766760012451 ABC transporter signature motif; other site 766760012452 Walker B; other site 766760012453 D-loop; other site 766760012454 H-loop/switch region; other site 766760012455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760012456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760012457 ATP binding site [chemical binding]; other site 766760012458 Mg2+ binding site [ion binding]; other site 766760012459 G-X-G motif; other site 766760012460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760012461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760012462 active site 766760012463 phosphorylation site [posttranslational modification] 766760012464 intermolecular recognition site; other site 766760012465 dimerization interface [polypeptide binding]; other site 766760012466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760012467 DNA binding site [nucleotide binding] 766760012468 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 766760012469 beta-galactosidase; Region: BGL; TIGR03356 766760012470 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 766760012471 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760012472 active site turn [active] 766760012473 phosphorylation site [posttranslational modification] 766760012474 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760012475 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 766760012476 HPr interaction site; other site 766760012477 glycerol kinase (GK) interaction site [polypeptide binding]; other site 766760012478 active site 766760012479 phosphorylation site [posttranslational modification] 766760012480 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 766760012481 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 766760012482 active site 766760012483 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 766760012484 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 766760012485 substrate binding site [chemical binding]; other site 766760012486 active site 766760012487 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 766760012488 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 766760012489 ATP binding site [chemical binding]; other site 766760012490 Mg++ binding site [ion binding]; other site 766760012491 motif III; other site 766760012492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 766760012493 nucleotide binding region [chemical binding]; other site 766760012494 ATP-binding site [chemical binding]; other site 766760012495 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 766760012496 RNA binding site [nucleotide binding]; other site 766760012497 LXG domain of WXG superfamily; Region: LXG; pfam04740 766760012498 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 766760012499 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 766760012500 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 766760012501 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 766760012502 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 766760012503 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 766760012504 Nucleoside recognition; Region: Gate; pfam07670 766760012505 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 766760012506 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 766760012507 intersubunit interface [polypeptide binding]; other site 766760012508 active site 766760012509 catalytic residue [active] 766760012510 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 766760012511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 766760012512 DNA binding residues [nucleotide binding] 766760012513 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 766760012514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 766760012515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 766760012516 metal binding site [ion binding]; metal-binding site 766760012517 active site 766760012518 I-site; other site 766760012519 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 766760012520 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 766760012521 NodB motif; other site 766760012522 putative active site [active] 766760012523 putative catalytic site [active] 766760012524 putative Zn binding site [ion binding]; other site 766760012525 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 766760012526 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 766760012527 DXD motif; other site 766760012528 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 766760012529 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 766760012530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 766760012531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 766760012532 homodimer interface [polypeptide binding]; other site 766760012533 catalytic residue [active] 766760012534 Prephenate dehydratase; Region: PDT; pfam00800 766760012535 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 766760012536 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 766760012537 EamA-like transporter family; Region: EamA; cl17759 766760012538 EamA-like transporter family; Region: EamA; pfam00892 766760012539 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 766760012540 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 766760012541 intersubunit interface [polypeptide binding]; other site 766760012542 active site 766760012543 zinc binding site [ion binding]; other site 766760012544 Na+ binding site [ion binding]; other site 766760012545 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 766760012546 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 766760012547 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 766760012548 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 766760012549 DNA interaction; other site 766760012550 Metal-binding active site; metal-binding site 766760012551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 766760012552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 766760012553 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 766760012554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012555 putative substrate translocation pore; other site 766760012556 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 766760012557 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 766760012558 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 766760012559 PYR/PP interface [polypeptide binding]; other site 766760012560 dimer interface [polypeptide binding]; other site 766760012561 TPP binding site [chemical binding]; other site 766760012562 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 766760012563 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 766760012564 TPP-binding site; other site 766760012565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 766760012566 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 766760012567 substrate binding site [chemical binding]; other site 766760012568 ATP binding site [chemical binding]; other site 766760012569 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 766760012570 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 766760012571 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 766760012572 tetrameric interface [polypeptide binding]; other site 766760012573 NAD binding site [chemical binding]; other site 766760012574 catalytic residues [active] 766760012575 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 766760012576 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 766760012577 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 766760012578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 766760012579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 766760012580 active site 766760012581 catalytic tetrad [active] 766760012582 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 766760012583 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 766760012584 active site 766760012585 catalytic site [active] 766760012586 metal binding site [ion binding]; metal-binding site 766760012587 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 766760012588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012589 putative substrate translocation pore; other site 766760012590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012591 heat shock protein 90; Provisional; Region: PRK05218 766760012592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760012593 ATP binding site [chemical binding]; other site 766760012594 Mg2+ binding site [ion binding]; other site 766760012595 G-X-G motif; other site 766760012596 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 766760012597 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 766760012598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760012599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760012600 ABC transporter; Region: ABC_tran_2; pfam12848 766760012601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 766760012602 sugar phosphate phosphatase; Provisional; Region: PRK10513 766760012603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760012604 active site 766760012605 motif I; other site 766760012606 motif II; other site 766760012607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 766760012608 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 766760012609 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 766760012610 active site 766760012611 metal binding site [ion binding]; metal-binding site 766760012612 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 766760012613 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760012614 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 766760012615 putative ligand binding residues [chemical binding]; other site 766760012616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 766760012617 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 766760012618 active site 766760012619 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 766760012620 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 766760012621 G1 box; other site 766760012622 GTP/Mg2+ binding site [chemical binding]; other site 766760012623 Switch I region; other site 766760012624 G2 box; other site 766760012625 G3 box; other site 766760012626 Switch II region; other site 766760012627 G4 box; other site 766760012628 G5 box; other site 766760012629 Nucleoside recognition; Region: Gate; pfam07670 766760012630 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 766760012631 Nucleoside recognition; Region: Gate; pfam07670 766760012632 FeoA domain; Region: FeoA; pfam04023 766760012633 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 766760012634 Acyltransferase family; Region: Acyl_transf_3; pfam01757 766760012635 FtsX-like permease family; Region: FtsX; pfam02687 766760012636 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 766760012637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 766760012638 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 766760012639 Walker A/P-loop; other site 766760012640 ATP binding site [chemical binding]; other site 766760012641 Q-loop/lid; other site 766760012642 ABC transporter signature motif; other site 766760012643 Walker B; other site 766760012644 D-loop; other site 766760012645 H-loop/switch region; other site 766760012646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 766760012647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760012648 dimer interface [polypeptide binding]; other site 766760012649 phosphorylation site [posttranslational modification] 766760012650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760012651 ATP binding site [chemical binding]; other site 766760012652 Mg2+ binding site [ion binding]; other site 766760012653 G-X-G motif; other site 766760012654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760012655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760012656 active site 766760012657 phosphorylation site [posttranslational modification] 766760012658 intermolecular recognition site; other site 766760012659 dimerization interface [polypeptide binding]; other site 766760012660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760012661 DNA binding site [nucleotide binding] 766760012662 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 766760012663 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 766760012664 dimerization interface [polypeptide binding]; other site 766760012665 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 766760012666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 766760012667 dimer interface [polypeptide binding]; other site 766760012668 putative CheW interface [polypeptide binding]; other site 766760012669 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 766760012670 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 766760012671 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 766760012672 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 766760012673 hexamer interface [polypeptide binding]; other site 766760012674 ligand binding site [chemical binding]; other site 766760012675 putative active site [active] 766760012676 NAD(P) binding site [chemical binding]; other site 766760012677 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 766760012678 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 766760012679 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 766760012680 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 766760012681 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 766760012682 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 766760012683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760012684 dimer interface [polypeptide binding]; other site 766760012685 conserved gate region; other site 766760012686 putative PBP binding loops; other site 766760012687 ABC-ATPase subunit interface; other site 766760012688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 766760012689 dimer interface [polypeptide binding]; other site 766760012690 conserved gate region; other site 766760012691 ABC-ATPase subunit interface; other site 766760012692 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 766760012693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 766760012694 Transcriptional regulators [Transcription]; Region: PurR; COG1609 766760012695 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 766760012696 DNA binding site [nucleotide binding] 766760012697 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 766760012698 putative dimerization interface [polypeptide binding]; other site 766760012699 putative ligand binding site [chemical binding]; other site 766760012700 galactokinase; Provisional; Region: PRK05322 766760012701 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 766760012702 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 766760012703 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 766760012704 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 766760012705 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 766760012706 NAD binding site [chemical binding]; other site 766760012707 homodimer interface [polypeptide binding]; other site 766760012708 active site 766760012709 substrate binding site [chemical binding]; other site 766760012710 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 766760012711 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 766760012712 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 766760012713 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 766760012714 non-specific DNA interactions [nucleotide binding]; other site 766760012715 DNA binding site [nucleotide binding] 766760012716 sequence specific DNA binding site [nucleotide binding]; other site 766760012717 putative cAMP binding site [chemical binding]; other site 766760012718 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 766760012719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 766760012720 nucleotide binding site [chemical binding]; other site 766760012721 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 766760012722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 766760012723 MarR family; Region: MarR_2; pfam12802 766760012724 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 766760012725 active site residue [active] 766760012726 hypothetical protein; Provisional; Region: PRK02268 766760012727 Transcriptional regulators [Transcription]; Region: GntR; COG1802 766760012728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760012729 DNA-binding site [nucleotide binding]; DNA binding site 766760012730 FCD domain; Region: FCD; pfam07729 766760012731 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 766760012732 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 766760012733 N- and C-terminal domain interface [polypeptide binding]; other site 766760012734 active site 766760012735 catalytic site [active] 766760012736 metal binding site [ion binding]; metal-binding site 766760012737 carbohydrate binding site [chemical binding]; other site 766760012738 ATP binding site [chemical binding]; other site 766760012739 fructuronate transporter; Provisional; Region: PRK10034; cl15264 766760012740 gluconate transporter; Region: gntP; TIGR00791 766760012741 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 766760012742 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 766760012743 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 766760012744 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 766760012745 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 766760012746 putative catalytic cysteine [active] 766760012747 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 766760012748 putative active site [active] 766760012749 metal binding site [ion binding]; metal-binding site 766760012750 peroxiredoxin; Region: AhpC; TIGR03137 766760012751 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 766760012752 dimer interface [polypeptide binding]; other site 766760012753 decamer (pentamer of dimers) interface [polypeptide binding]; other site 766760012754 catalytic triad [active] 766760012755 peroxidatic and resolving cysteines [active] 766760012756 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 766760012757 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 766760012758 catalytic residue [active] 766760012759 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 766760012760 catalytic residues [active] 766760012761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 766760012762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 766760012763 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 766760012764 HTH domain; Region: HTH_11; pfam08279 766760012765 Predicted transcriptional regulator [Transcription]; Region: COG2378 766760012766 WYL domain; Region: WYL; pfam13280 766760012767 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 766760012768 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 766760012769 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 766760012770 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 766760012771 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 766760012772 putative ligand binding residues [chemical binding]; other site 766760012773 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 766760012774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760012775 ABC-ATPase subunit interface; other site 766760012776 dimer interface [polypeptide binding]; other site 766760012777 putative PBP binding regions; other site 766760012778 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 766760012779 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 766760012780 ABC-ATPase subunit interface; other site 766760012781 dimer interface [polypeptide binding]; other site 766760012782 putative PBP binding regions; other site 766760012783 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 766760012784 GIY-YIG motif/motif A; other site 766760012785 putative active site [active] 766760012786 putative metal binding site [ion binding]; other site 766760012787 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 766760012788 Uncharacterized conserved protein [Function unknown]; Region: COG3410 766760012789 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 766760012790 homodimer interface [polypeptide binding]; other site 766760012791 chemical substrate binding site [chemical binding]; other site 766760012792 oligomer interface [polypeptide binding]; other site 766760012793 metal binding site [ion binding]; metal-binding site 766760012794 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 766760012795 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 766760012796 Walker A/P-loop; other site 766760012797 ATP binding site [chemical binding]; other site 766760012798 Q-loop/lid; other site 766760012799 ABC transporter signature motif; other site 766760012800 Walker B; other site 766760012801 D-loop; other site 766760012802 H-loop/switch region; other site 766760012803 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 766760012804 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 766760012805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 766760012806 Histidine kinase; Region: HisKA_3; pfam07730 766760012807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 766760012808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760012809 active site 766760012810 phosphorylation site [posttranslational modification] 766760012811 intermolecular recognition site; other site 766760012812 dimerization interface [polypeptide binding]; other site 766760012813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 766760012814 DNA binding residues [nucleotide binding] 766760012815 dimerization interface [polypeptide binding]; other site 766760012816 AAA domain; Region: AAA_22; pfam13401 766760012817 AAA domain; Region: AAA_30; pfam13604 766760012818 Family description; Region: UvrD_C_2; pfam13538 766760012819 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 766760012820 YyzF-like protein; Region: YyzF; pfam14116 766760012821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 766760012822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 766760012823 Coenzyme A binding pocket [chemical binding]; other site 766760012824 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 766760012825 Uncharacterized conserved protein [Function unknown]; Region: COG1912 766760012826 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 766760012827 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 766760012828 protein binding site [polypeptide binding]; other site 766760012829 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 766760012830 YycH protein; Region: YycI; cl02015 766760012831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 766760012832 YycH protein; Region: YycH; pfam07435 766760012833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 766760012834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 766760012835 dimerization interface [polypeptide binding]; other site 766760012836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 766760012837 putative active site [active] 766760012838 heme pocket [chemical binding]; other site 766760012839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 766760012840 dimer interface [polypeptide binding]; other site 766760012841 phosphorylation site [posttranslational modification] 766760012842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 766760012843 ATP binding site [chemical binding]; other site 766760012844 Mg2+ binding site [ion binding]; other site 766760012845 G-X-G motif; other site 766760012846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 766760012847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 766760012848 active site 766760012849 phosphorylation site [posttranslational modification] 766760012850 intermolecular recognition site; other site 766760012851 dimerization interface [polypeptide binding]; other site 766760012852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 766760012853 DNA binding site [nucleotide binding] 766760012854 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 766760012855 nudix motif; other site 766760012856 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 766760012857 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 766760012858 GDP-binding site [chemical binding]; other site 766760012859 ACT binding site; other site 766760012860 IMP binding site; other site 766760012861 replicative DNA helicase; Provisional; Region: PRK05748 766760012862 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 766760012863 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 766760012864 Walker A motif; other site 766760012865 ATP binding site [chemical binding]; other site 766760012866 Walker B motif; other site 766760012867 DNA binding loops [nucleotide binding] 766760012868 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 766760012869 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 766760012870 YycC-like protein; Region: YycC; pfam14174 766760012871 cyanate transporter; Region: CynX; TIGR00896 766760012872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012873 putative substrate translocation pore; other site 766760012874 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 766760012875 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 766760012876 active site 766760012877 dimer interface [polypeptide binding]; other site 766760012878 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 766760012879 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 766760012880 active site 766760012881 trimer interface [polypeptide binding]; other site 766760012882 allosteric site; other site 766760012883 active site lid [active] 766760012884 hexamer (dimer of trimers) interface [polypeptide binding]; other site 766760012885 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 766760012886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 766760012887 DNA-binding site [nucleotide binding]; DNA binding site 766760012888 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 766760012889 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 766760012890 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 766760012891 putative active site [active] 766760012892 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 766760012893 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 766760012894 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 766760012895 active site turn [active] 766760012896 phosphorylation site [posttranslational modification] 766760012897 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 766760012898 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 766760012899 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 766760012900 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 766760012901 diguanylate cyclase; Region: GGDEF; smart00267 766760012902 DHH family; Region: DHH; pfam01368 766760012903 DHHA1 domain; Region: DHHA1; pfam02272 766760012904 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 766760012905 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 766760012906 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 766760012907 Ligand Binding Site [chemical binding]; other site 766760012908 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 766760012909 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 766760012910 Sulfate transporter family; Region: Sulfate_transp; pfam00916 766760012911 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 766760012912 D-galactonate transporter; Region: 2A0114; TIGR00893 766760012913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 766760012914 putative substrate translocation pore; other site 766760012915 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 766760012916 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 766760012917 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 766760012918 dimer interface [polypeptide binding]; other site 766760012919 ssDNA binding site [nucleotide binding]; other site 766760012920 tetramer (dimer of dimers) interface [polypeptide binding]; other site 766760012921 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 766760012922 GTP-binding protein YchF; Reviewed; Region: PRK09601 766760012923 YchF GTPase; Region: YchF; cd01900 766760012924 G1 box; other site 766760012925 GTP/Mg2+ binding site [chemical binding]; other site 766760012926 Switch I region; other site 766760012927 G2 box; other site 766760012928 Switch II region; other site 766760012929 G3 box; other site 766760012930 G4 box; other site 766760012931 G5 box; other site 766760012932 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 766760012933 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 766760012934 Uncharacterized membrane protein [Function unknown]; Region: COG3949 766760012935 Spore germination protein; Region: Spore_permease; cl17796 766760012936 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 766760012937 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 766760012938 ParB-like nuclease domain; Region: ParB; smart00470 766760012939 KorB domain; Region: KorB; pfam08535 766760012940 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 766760012941 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 766760012942 P-loop; other site 766760012943 Magnesium ion binding site [ion binding]; other site 766760012944 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 766760012945 Magnesium ion binding site [ion binding]; other site 766760012946 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 766760012947 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 766760012948 Uncharacterized conserved protein [Function unknown]; Region: COG2128 766760012949 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 766760012950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 766760012951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 766760012952 DNA binding residues [nucleotide binding] 766760012953 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 766760012954 ParB-like nuclease domain; Region: ParB; smart00470 766760012955 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 766760012956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 766760012957 S-adenosylmethionine binding site [chemical binding]; other site 766760012958 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 766760012959 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 766760012960 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 766760012961 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 766760012962 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 766760012963 trmE is a tRNA modification GTPase; Region: trmE; cd04164 766760012964 G1 box; other site 766760012965 GTP/Mg2+ binding site [chemical binding]; other site 766760012966 Switch I region; other site 766760012967 G2 box; other site 766760012968 Switch II region; other site 766760012969 G3 box; other site 766760012970 G4 box; other site 766760012971 G5 box; other site 766760012972 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 766760012973 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 766760012974 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 766760012975 G-X-X-G motif; other site 766760012976 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 766760012977 RxxxH motif; other site 766760012978 OxaA-like protein precursor; Validated; Region: PRK02944 766760012979 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 766760012980 ribonuclease P; Reviewed; Region: rnpA; PRK00499 766760012981 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399