-- dump date 20140618_222928 -- class Genbank::misc_feature -- table misc_feature_note -- id note 279010000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 279010000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 279010000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000004 Walker A motif; other site 279010000005 ATP binding site [chemical binding]; other site 279010000006 Walker B motif; other site 279010000007 arginine finger; other site 279010000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 279010000009 DnaA box-binding interface [nucleotide binding]; other site 279010000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 279010000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 279010000012 putative DNA binding surface [nucleotide binding]; other site 279010000013 dimer interface [polypeptide binding]; other site 279010000014 beta-clamp/clamp loader binding surface; other site 279010000015 beta-clamp/translesion DNA polymerase binding surface; other site 279010000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 279010000017 recombination protein F; Reviewed; Region: recF; PRK00064 279010000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 279010000019 Walker A/P-loop; other site 279010000020 ATP binding site [chemical binding]; other site 279010000021 Q-loop/lid; other site 279010000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010000023 ABC transporter signature motif; other site 279010000024 Walker B; other site 279010000025 D-loop; other site 279010000026 H-loop/switch region; other site 279010000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 279010000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000029 ATP binding site [chemical binding]; other site 279010000030 Mg2+ binding site [ion binding]; other site 279010000031 G-X-G motif; other site 279010000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 279010000033 anchoring element; other site 279010000034 dimer interface [polypeptide binding]; other site 279010000035 ATP binding site [chemical binding]; other site 279010000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 279010000037 active site 279010000038 putative metal-binding site [ion binding]; other site 279010000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 279010000040 DNA gyrase subunit A; Validated; Region: PRK05560 279010000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 279010000042 CAP-like domain; other site 279010000043 active site 279010000044 primary dimer interface [polypeptide binding]; other site 279010000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000051 YaaC-like Protein; Region: YaaC; pfam14175 279010000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 279010000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 279010000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 279010000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 279010000056 active site 279010000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 279010000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 279010000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 279010000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 279010000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 279010000062 active site 279010000063 multimer interface [polypeptide binding]; other site 279010000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 279010000065 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 279010000066 predicted active site [active] 279010000067 catalytic triad [active] 279010000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 279010000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 279010000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 279010000071 dimer interface [polypeptide binding]; other site 279010000072 active site 279010000073 motif 1; other site 279010000074 motif 2; other site 279010000075 motif 3; other site 279010000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 279010000077 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 279010000078 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 279010000079 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 279010000080 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 279010000081 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 279010000082 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 279010000083 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 279010000084 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 279010000085 Substrate-binding site [chemical binding]; other site 279010000086 Substrate specificity [chemical binding]; other site 279010000087 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 279010000088 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 279010000089 Substrate-binding site [chemical binding]; other site 279010000090 Substrate specificity [chemical binding]; other site 279010000091 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 279010000092 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010000093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010000094 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 279010000095 active site 279010000096 Isochorismatase family; Region: Isochorismatase; pfam00857 279010000097 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 279010000098 catalytic triad [active] 279010000099 conserved cis-peptide bond; other site 279010000100 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 279010000101 nucleoside/Zn binding site; other site 279010000102 dimer interface [polypeptide binding]; other site 279010000103 catalytic motif [active] 279010000104 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 279010000105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000106 Walker A motif; other site 279010000107 ATP binding site [chemical binding]; other site 279010000108 Walker B motif; other site 279010000109 arginine finger; other site 279010000110 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 279010000111 hypothetical protein; Validated; Region: PRK00153 279010000112 recombination protein RecR; Reviewed; Region: recR; PRK00076 279010000113 RecR protein; Region: RecR; pfam02132 279010000114 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 279010000115 putative active site [active] 279010000116 putative metal-binding site [ion binding]; other site 279010000117 tetramer interface [polypeptide binding]; other site 279010000118 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 279010000119 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 279010000120 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 279010000121 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 279010000122 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 279010000123 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 279010000124 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 279010000125 homodimer interface [polypeptide binding]; other site 279010000126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010000127 catalytic residue [active] 279010000128 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 279010000129 thymidylate kinase; Validated; Region: tmk; PRK00698 279010000130 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 279010000131 TMP-binding site; other site 279010000132 ATP-binding site [chemical binding]; other site 279010000133 Protein of unknown function (DUF970); Region: DUF970; pfam06153 279010000134 Protein of unknown function (DUF327); Region: DUF327; pfam03885 279010000135 DNA polymerase III subunit delta'; Validated; Region: PRK08058 279010000136 DNA polymerase III subunit delta'; Validated; Region: PRK08485 279010000137 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 279010000138 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 279010000139 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 279010000140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000141 S-adenosylmethionine binding site [chemical binding]; other site 279010000142 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 279010000143 GIY-YIG motif/motif A; other site 279010000144 putative active site [active] 279010000145 putative metal binding site [ion binding]; other site 279010000146 Predicted methyltransferases [General function prediction only]; Region: COG0313 279010000147 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 279010000148 putative SAM binding site [chemical binding]; other site 279010000149 putative homodimer interface [polypeptide binding]; other site 279010000150 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 279010000151 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 279010000152 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 279010000153 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 279010000154 active site 279010000155 HIGH motif; other site 279010000156 KMSKS motif; other site 279010000157 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 279010000158 tRNA binding surface [nucleotide binding]; other site 279010000159 anticodon binding site; other site 279010000160 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 279010000161 dimer interface [polypeptide binding]; other site 279010000162 putative tRNA-binding site [nucleotide binding]; other site 279010000163 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 279010000164 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 279010000165 active site 279010000166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 279010000167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 279010000168 Domain of unknown function (DUF348); Region: DUF348; pfam03990 279010000169 Domain of unknown function (DUF348); Region: DUF348; pfam03990 279010000170 G5 domain; Region: G5; pfam07501 279010000171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 279010000172 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 279010000173 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 279010000174 putative active site [active] 279010000175 putative metal binding site [ion binding]; other site 279010000176 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 279010000177 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 279010000178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000179 S-adenosylmethionine binding site [chemical binding]; other site 279010000180 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 279010000181 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 279010000182 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010000183 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 279010000184 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279010000185 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279010000186 pur operon repressor; Provisional; Region: PRK09213 279010000187 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 279010000188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010000189 active site 279010000190 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279010000191 homotrimer interaction site [polypeptide binding]; other site 279010000192 putative active site [active] 279010000193 regulatory protein SpoVG; Reviewed; Region: PRK13259 279010000194 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 279010000195 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 279010000196 Substrate binding site; other site 279010000197 Mg++ binding site; other site 279010000198 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 279010000199 active site 279010000200 substrate binding site [chemical binding]; other site 279010000201 CoA binding site [chemical binding]; other site 279010000202 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 279010000203 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 279010000204 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010000205 active site 279010000206 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 279010000207 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 279010000208 5S rRNA interface [nucleotide binding]; other site 279010000209 CTC domain interface [polypeptide binding]; other site 279010000210 L16 interface [polypeptide binding]; other site 279010000211 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 279010000212 putative active site [active] 279010000213 catalytic residue [active] 279010000214 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 279010000215 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 279010000216 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 279010000217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010000218 ATP binding site [chemical binding]; other site 279010000219 putative Mg++ binding site [ion binding]; other site 279010000220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010000221 nucleotide binding region [chemical binding]; other site 279010000222 ATP-binding site [chemical binding]; other site 279010000223 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 279010000224 stage V sporulation protein T; Region: spore_V_T; TIGR02851 279010000225 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 279010000226 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 279010000227 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 279010000228 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 279010000229 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 279010000230 putative SAM binding site [chemical binding]; other site 279010000231 putative homodimer interface [polypeptide binding]; other site 279010000232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 279010000233 homodimer interface [polypeptide binding]; other site 279010000234 metal binding site [ion binding]; metal-binding site 279010000235 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 279010000236 homodimer interface [polypeptide binding]; other site 279010000237 active site 279010000238 putative chemical substrate binding site [chemical binding]; other site 279010000239 metal binding site [ion binding]; metal-binding site 279010000240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010000241 RNA binding surface [nucleotide binding]; other site 279010000242 sporulation protein YabP; Region: spore_yabP; TIGR02892 279010000243 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 279010000244 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 279010000245 Septum formation initiator; Region: DivIC; pfam04977 279010000246 hypothetical protein; Provisional; Region: PRK08582 279010000247 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 279010000248 RNA binding site [nucleotide binding]; other site 279010000249 stage II sporulation protein E; Region: spore_II_E; TIGR02865 279010000250 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 279010000251 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 279010000252 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010000253 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 279010000254 metal ion-dependent adhesion site (MIDAS); other site 279010000255 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 279010000256 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010000257 active site 279010000258 ATP binding site [chemical binding]; other site 279010000259 substrate binding site [chemical binding]; other site 279010000260 activation loop (A-loop); other site 279010000261 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 279010000262 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 279010000263 Ligand Binding Site [chemical binding]; other site 279010000264 TilS substrate binding domain; Region: TilS; pfam09179 279010000265 TilS substrate C-terminal domain; Region: TilS_C; smart00977 279010000266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010000267 active site 279010000268 FtsH Extracellular; Region: FtsH_ext; pfam06480 279010000269 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 279010000270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000271 Walker A motif; other site 279010000272 ATP binding site [chemical binding]; other site 279010000273 Walker B motif; other site 279010000274 arginine finger; other site 279010000275 Peptidase family M41; Region: Peptidase_M41; pfam01434 279010000276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010000277 nucleotide binding site [chemical binding]; other site 279010000278 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 279010000279 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 279010000280 dimerization interface [polypeptide binding]; other site 279010000281 domain crossover interface; other site 279010000282 redox-dependent activation switch; other site 279010000283 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 279010000284 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 279010000285 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279010000286 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279010000287 dimer interface [polypeptide binding]; other site 279010000288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010000289 catalytic residue [active] 279010000290 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 279010000291 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 279010000292 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 279010000293 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 279010000294 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 279010000295 glutamine binding [chemical binding]; other site 279010000296 catalytic triad [active] 279010000297 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 279010000298 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 279010000299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010000300 catalytic residue [active] 279010000301 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 279010000302 dihydropteroate synthase; Region: DHPS; TIGR01496 279010000303 substrate binding pocket [chemical binding]; other site 279010000304 dimer interface [polypeptide binding]; other site 279010000305 inhibitor binding site; inhibition site 279010000306 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 279010000307 homooctamer interface [polypeptide binding]; other site 279010000308 active site 279010000309 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 279010000310 catalytic center binding site [active] 279010000311 ATP binding site [chemical binding]; other site 279010000312 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 279010000313 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 279010000314 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 279010000315 FMN binding site [chemical binding]; other site 279010000316 active site 279010000317 catalytic residues [active] 279010000318 substrate binding site [chemical binding]; other site 279010000319 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 279010000320 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 279010000321 dimer interface [polypeptide binding]; other site 279010000322 putative anticodon binding site; other site 279010000323 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 279010000324 motif 1; other site 279010000325 active site 279010000326 motif 2; other site 279010000327 motif 3; other site 279010000328 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 279010000329 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 279010000330 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 279010000331 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 279010000332 ADP binding site [chemical binding]; other site 279010000333 phosphagen binding site; other site 279010000334 substrate specificity loop; other site 279010000335 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 279010000336 Clp amino terminal domain; Region: Clp_N; pfam02861 279010000337 Clp amino terminal domain; Region: Clp_N; pfam02861 279010000338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000339 Walker A motif; other site 279010000340 ATP binding site [chemical binding]; other site 279010000341 Walker B motif; other site 279010000342 arginine finger; other site 279010000343 UvrB/uvrC motif; Region: UVR; pfam02151 279010000344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000345 Walker A motif; other site 279010000346 ATP binding site [chemical binding]; other site 279010000347 Walker B motif; other site 279010000348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 279010000349 DNA repair protein RadA; Provisional; Region: PRK11823 279010000350 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 279010000351 Walker A motif/ATP binding site; other site 279010000352 ATP binding site [chemical binding]; other site 279010000353 Walker B motif; other site 279010000354 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 279010000355 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 279010000356 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 279010000357 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 279010000358 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 279010000359 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 279010000360 putative active site [active] 279010000361 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 279010000362 substrate binding site; other site 279010000363 dimer interface; other site 279010000364 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 279010000365 homotrimer interaction site [polypeptide binding]; other site 279010000366 zinc binding site [ion binding]; other site 279010000367 CDP-binding sites; other site 279010000368 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 279010000369 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 279010000370 HIGH motif; other site 279010000371 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 279010000372 active site 279010000373 KMSKS motif; other site 279010000374 serine O-acetyltransferase; Region: cysE; TIGR01172 279010000375 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 279010000376 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 279010000377 trimer interface [polypeptide binding]; other site 279010000378 active site 279010000379 substrate binding site [chemical binding]; other site 279010000380 CoA binding site [chemical binding]; other site 279010000381 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 279010000382 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 279010000383 active site 279010000384 HIGH motif; other site 279010000385 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 279010000386 KMSKS motif; other site 279010000387 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 279010000388 tRNA binding surface [nucleotide binding]; other site 279010000389 anticodon binding site; other site 279010000390 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 279010000391 active site 279010000392 metal binding site [ion binding]; metal-binding site 279010000393 dimerization interface [polypeptide binding]; other site 279010000394 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 279010000395 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 279010000396 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 279010000397 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 279010000398 RNA polymerase factor sigma-70; Validated; Region: PRK08295 279010000399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010000400 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 279010000401 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 279010000402 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 279010000403 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 279010000404 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 279010000405 putative homodimer interface [polypeptide binding]; other site 279010000406 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 279010000407 heterodimer interface [polypeptide binding]; other site 279010000408 homodimer interface [polypeptide binding]; other site 279010000409 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 279010000410 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 279010000411 23S rRNA interface [nucleotide binding]; other site 279010000412 L7/L12 interface [polypeptide binding]; other site 279010000413 putative thiostrepton binding site; other site 279010000414 L25 interface [polypeptide binding]; other site 279010000415 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 279010000416 mRNA/rRNA interface [nucleotide binding]; other site 279010000417 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 279010000418 23S rRNA interface [nucleotide binding]; other site 279010000419 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 279010000420 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 279010000421 core dimer interface [polypeptide binding]; other site 279010000422 peripheral dimer interface [polypeptide binding]; other site 279010000423 L10 interface [polypeptide binding]; other site 279010000424 L11 interface [polypeptide binding]; other site 279010000425 putative EF-Tu interaction site [polypeptide binding]; other site 279010000426 putative EF-G interaction site [polypeptide binding]; other site 279010000427 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 279010000428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000429 S-adenosylmethionine binding site [chemical binding]; other site 279010000430 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 279010000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 279010000432 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 279010000433 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 279010000434 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 279010000435 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 279010000436 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 279010000437 RPB10 interaction site [polypeptide binding]; other site 279010000438 RPB1 interaction site [polypeptide binding]; other site 279010000439 RPB11 interaction site [polypeptide binding]; other site 279010000440 RPB3 interaction site [polypeptide binding]; other site 279010000441 RPB12 interaction site [polypeptide binding]; other site 279010000442 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 279010000443 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 279010000444 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 279010000445 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 279010000446 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 279010000447 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 279010000448 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 279010000449 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 279010000450 G-loop; other site 279010000451 DNA binding site [nucleotide binding] 279010000452 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 279010000453 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 279010000454 S17 interaction site [polypeptide binding]; other site 279010000455 S8 interaction site; other site 279010000456 16S rRNA interaction site [nucleotide binding]; other site 279010000457 streptomycin interaction site [chemical binding]; other site 279010000458 23S rRNA interaction site [nucleotide binding]; other site 279010000459 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 279010000460 30S ribosomal protein S7; Validated; Region: PRK05302 279010000461 elongation factor G; Reviewed; Region: PRK00007 279010000462 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 279010000463 G1 box; other site 279010000464 putative GEF interaction site [polypeptide binding]; other site 279010000465 GTP/Mg2+ binding site [chemical binding]; other site 279010000466 Switch I region; other site 279010000467 G2 box; other site 279010000468 G3 box; other site 279010000469 Switch II region; other site 279010000470 G4 box; other site 279010000471 G5 box; other site 279010000472 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 279010000473 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 279010000474 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 279010000475 elongation factor Tu; Reviewed; Region: PRK00049 279010000476 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 279010000477 G1 box; other site 279010000478 GEF interaction site [polypeptide binding]; other site 279010000479 GTP/Mg2+ binding site [chemical binding]; other site 279010000480 Switch I region; other site 279010000481 G2 box; other site 279010000482 G3 box; other site 279010000483 Switch II region; other site 279010000484 G4 box; other site 279010000485 G5 box; other site 279010000486 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 279010000487 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 279010000488 Antibiotic Binding Site [chemical binding]; other site 279010000489 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 279010000490 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 279010000491 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 279010000492 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 279010000493 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 279010000494 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 279010000495 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 279010000496 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 279010000497 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 279010000498 putative translocon binding site; other site 279010000499 protein-rRNA interface [nucleotide binding]; other site 279010000500 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 279010000501 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 279010000502 G-X-X-G motif; other site 279010000503 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 279010000504 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 279010000505 23S rRNA interface [nucleotide binding]; other site 279010000506 5S rRNA interface [nucleotide binding]; other site 279010000507 putative antibiotic binding site [chemical binding]; other site 279010000508 L25 interface [polypeptide binding]; other site 279010000509 L27 interface [polypeptide binding]; other site 279010000510 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 279010000511 23S rRNA interface [nucleotide binding]; other site 279010000512 putative translocon interaction site; other site 279010000513 signal recognition particle (SRP54) interaction site; other site 279010000514 L23 interface [polypeptide binding]; other site 279010000515 trigger factor interaction site; other site 279010000516 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 279010000517 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 279010000518 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 279010000519 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 279010000520 RNA binding site [nucleotide binding]; other site 279010000521 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 279010000522 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 279010000523 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 279010000524 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 279010000525 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 279010000526 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 279010000527 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 279010000528 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 279010000529 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 279010000530 5S rRNA interface [nucleotide binding]; other site 279010000531 L27 interface [polypeptide binding]; other site 279010000532 23S rRNA interface [nucleotide binding]; other site 279010000533 L5 interface [polypeptide binding]; other site 279010000534 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 279010000535 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 279010000536 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 279010000537 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 279010000538 23S rRNA binding site [nucleotide binding]; other site 279010000539 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 279010000540 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 279010000541 SecY translocase; Region: SecY; pfam00344 279010000542 adenylate kinase; Reviewed; Region: adk; PRK00279 279010000543 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 279010000544 AMP-binding site [chemical binding]; other site 279010000545 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 279010000546 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 279010000547 active site 279010000548 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 279010000549 RNA binding site [nucleotide binding]; other site 279010000550 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 279010000551 rRNA binding site [nucleotide binding]; other site 279010000552 predicted 30S ribosome binding site; other site 279010000553 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 279010000554 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 279010000555 30S ribosomal protein S13; Region: bact_S13; TIGR03631 279010000556 30S ribosomal protein S11; Validated; Region: PRK05309 279010000557 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 279010000558 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 279010000559 alphaNTD homodimer interface [polypeptide binding]; other site 279010000560 alphaNTD - beta interaction site [polypeptide binding]; other site 279010000561 alphaNTD - beta' interaction site [polypeptide binding]; other site 279010000562 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 279010000563 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 279010000564 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 279010000565 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279010000566 Walker A/P-loop; other site 279010000567 ATP binding site [chemical binding]; other site 279010000568 Q-loop/lid; other site 279010000569 ABC transporter signature motif; other site 279010000570 Walker B; other site 279010000571 D-loop; other site 279010000572 H-loop/switch region; other site 279010000573 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 279010000574 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279010000575 Walker A/P-loop; other site 279010000576 ATP binding site [chemical binding]; other site 279010000577 Q-loop/lid; other site 279010000578 ABC transporter signature motif; other site 279010000579 Walker B; other site 279010000580 D-loop; other site 279010000581 H-loop/switch region; other site 279010000582 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 279010000583 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 279010000584 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 279010000585 dimerization interface 3.5A [polypeptide binding]; other site 279010000586 active site 279010000587 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 279010000588 23S rRNA interface [nucleotide binding]; other site 279010000589 L3 interface [polypeptide binding]; other site 279010000590 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 279010000591 DinB family; Region: DinB; cl17821 279010000592 DinB superfamily; Region: DinB_2; pfam12867 279010000593 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 279010000594 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010000595 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010000596 active site 279010000597 metal binding site [ion binding]; metal-binding site 279010000598 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 279010000599 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 279010000600 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 279010000601 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279010000602 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 279010000603 Beta-lactamase; Region: Beta-lactamase; pfam00144 279010000604 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279010000605 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 279010000606 Sodium Bile acid symporter family; Region: SBF; cl17470 279010000607 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 279010000608 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 279010000609 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 279010000610 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 279010000611 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 279010000612 putative periplasmic esterase; Provisional; Region: PRK03642 279010000613 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279010000614 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010000615 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 279010000616 active site turn [active] 279010000617 phosphorylation site [posttranslational modification] 279010000618 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010000619 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279010000620 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010000621 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279010000622 putative active site [active] 279010000623 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 279010000624 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 279010000625 putative active site [active] 279010000626 Uncharacterized conserved protein [Function unknown]; Region: COG1683 279010000627 Arginase family; Region: Arginase; cd09989 279010000628 agmatinase; Region: agmatinase; TIGR01230 279010000629 active site 279010000630 Mn binding site [ion binding]; other site 279010000631 oligomer interface [polypeptide binding]; other site 279010000632 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 279010000633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010000634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010000635 DNA binding residues [nucleotide binding] 279010000636 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 279010000637 Putative zinc-finger; Region: zf-HC2; pfam13490 279010000638 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 279010000639 Uncharacterized conserved protein [Function unknown]; Region: COG1624 279010000640 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 279010000641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 279010000642 YbbR-like protein; Region: YbbR; pfam07949 279010000643 YbbR-like protein; Region: YbbR; pfam07949 279010000644 YbbR-like protein; Region: YbbR; pfam07949 279010000645 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 279010000646 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 279010000647 active site 279010000648 substrate binding site [chemical binding]; other site 279010000649 metal binding site [ion binding]; metal-binding site 279010000650 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 279010000651 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 279010000652 glutaminase active site [active] 279010000653 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 279010000654 dimer interface [polypeptide binding]; other site 279010000655 active site 279010000656 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 279010000657 dimer interface [polypeptide binding]; other site 279010000658 active site 279010000659 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 279010000660 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 279010000661 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010000662 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010000663 Walker A/P-loop; other site 279010000664 ATP binding site [chemical binding]; other site 279010000665 Q-loop/lid; other site 279010000666 ABC transporter signature motif; other site 279010000667 Walker B; other site 279010000668 D-loop; other site 279010000669 H-loop/switch region; other site 279010000670 Predicted transcriptional regulators [Transcription]; Region: COG1725 279010000671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010000672 DNA-binding site [nucleotide binding]; DNA binding site 279010000673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010000674 putative Zn2+ binding site [ion binding]; other site 279010000675 putative DNA binding site [nucleotide binding]; other site 279010000676 dimerization interface [polypeptide binding]; other site 279010000677 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010000678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000679 putative substrate translocation pore; other site 279010000680 DinB superfamily; Region: DinB_2; pfam12867 279010000681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010000682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010000683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010000684 Walker A/P-loop; other site 279010000685 ATP binding site [chemical binding]; other site 279010000686 Q-loop/lid; other site 279010000687 ABC transporter signature motif; other site 279010000688 Walker B; other site 279010000689 D-loop; other site 279010000690 H-loop/switch region; other site 279010000691 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 279010000692 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 279010000693 catalytic residues [active] 279010000694 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 279010000695 putative hydrophobic ligand binding site [chemical binding]; other site 279010000696 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 279010000697 Phosphotransferase enzyme family; Region: APH; pfam01636 279010000698 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 279010000699 active site 279010000700 ATP binding site [chemical binding]; other site 279010000701 active site 279010000702 ATP binding site [chemical binding]; other site 279010000703 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 279010000704 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 279010000705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010000706 active site 279010000707 motif I; other site 279010000708 motif II; other site 279010000709 putative transport protein YifK; Provisional; Region: PRK10746 279010000710 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 279010000711 Citrate transporter; Region: CitMHS; pfam03600 279010000712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 279010000713 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 279010000714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000715 active site 279010000716 phosphorylation site [posttranslational modification] 279010000717 intermolecular recognition site; other site 279010000718 dimerization interface [polypeptide binding]; other site 279010000719 Transcriptional regulator; Region: CitT; pfam12431 279010000720 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 279010000721 PAS domain; Region: PAS; smart00091 279010000722 putative active site [active] 279010000723 heme pocket [chemical binding]; other site 279010000724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000725 ATP binding site [chemical binding]; other site 279010000726 Mg2+ binding site [ion binding]; other site 279010000727 G-X-G motif; other site 279010000728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010000729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010000730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010000731 dimerization interface [polypeptide binding]; other site 279010000732 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 279010000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000734 putative transporter; Provisional; Region: PRK10054 279010000735 putative substrate translocation pore; other site 279010000736 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 279010000737 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279010000738 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 279010000739 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 279010000740 active site 279010000741 dimer interface [polypeptide binding]; other site 279010000742 motif 1; other site 279010000743 motif 2; other site 279010000744 motif 3; other site 279010000745 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 279010000746 anticodon binding site; other site 279010000747 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010000748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000749 hypothetical protein; Provisional; Region: PRK05409 279010000750 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010000751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010000752 Transporter associated domain; Region: CorC_HlyC; smart01091 279010000753 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 279010000754 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 279010000755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010000757 putative substrate translocation pore; other site 279010000758 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 279010000759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000760 S-adenosylmethionine binding site [chemical binding]; other site 279010000761 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 279010000762 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 279010000763 NADP binding site [chemical binding]; other site 279010000764 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 279010000765 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 279010000766 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010000767 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010000768 PhoU domain; Region: PhoU; pfam01895 279010000769 PhoU domain; Region: PhoU; pfam01895 279010000770 yiaA/B two helix domain; Region: YiaAB; pfam05360 279010000771 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 279010000772 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 279010000773 EamA-like transporter family; Region: EamA; pfam00892 279010000774 EamA-like transporter family; Region: EamA; pfam00892 279010000775 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010000776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010000777 non-specific DNA binding site [nucleotide binding]; other site 279010000778 salt bridge; other site 279010000779 sequence-specific DNA binding site [nucleotide binding]; other site 279010000780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010000781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010000782 DNA binding residues [nucleotide binding] 279010000783 dimerization interface [polypeptide binding]; other site 279010000784 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010000785 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 279010000786 putative active site [active] 279010000787 metal binding site [ion binding]; metal-binding site 279010000788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010000789 dimerization interface [polypeptide binding]; other site 279010000790 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010000791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010000792 dimer interface [polypeptide binding]; other site 279010000793 putative CheW interface [polypeptide binding]; other site 279010000794 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 279010000795 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 279010000796 putative ligand binding site [chemical binding]; other site 279010000797 SurA N-terminal domain; Region: SurA_N_3; cl07813 279010000798 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 279010000799 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 279010000800 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 279010000801 S-methylmethionine transporter; Provisional; Region: PRK11387 279010000802 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 279010000803 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 279010000804 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 279010000805 putative active site [active] 279010000806 YdjC motif; other site 279010000807 Mg binding site [ion binding]; other site 279010000808 putative homodimer interface [polypeptide binding]; other site 279010000809 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 279010000810 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010000811 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010000812 active site turn [active] 279010000813 phosphorylation site [posttranslational modification] 279010000814 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010000815 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010000816 DNA binding residues [nucleotide binding] 279010000817 dimer interface [polypeptide binding]; other site 279010000818 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 279010000819 Predicted membrane protein [Function unknown]; Region: COG2323 279010000820 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 279010000821 trimer interface [polypeptide binding]; other site 279010000822 active site 279010000823 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 279010000824 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010000825 amino acid carrier protein; Region: agcS; TIGR00835 279010000826 glutaminase; Reviewed; Region: PRK12357 279010000827 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 279010000828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010000829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000830 ATP binding site [chemical binding]; other site 279010000831 Mg2+ binding site [ion binding]; other site 279010000832 G-X-G motif; other site 279010000833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000834 Response regulator receiver domain; Region: Response_reg; pfam00072 279010000835 active site 279010000836 phosphorylation site [posttranslational modification] 279010000837 intermolecular recognition site; other site 279010000838 dimerization interface [polypeptide binding]; other site 279010000839 YcbB domain; Region: YcbB; pfam08664 279010000840 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010000841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010000842 Coenzyme A binding pocket [chemical binding]; other site 279010000843 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 279010000844 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 279010000845 Penicillinase repressor; Region: Pencillinase_R; pfam03965 279010000846 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 279010000847 PhoD-like phosphatase; Region: PhoD; pfam09423 279010000848 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 279010000849 putative active site [active] 279010000850 putative metal binding site [ion binding]; other site 279010000851 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 279010000852 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 279010000853 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 279010000854 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 279010000855 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279010000856 putative active site [active] 279010000857 catalytic residue [active] 279010000858 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 279010000859 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010000860 NAD(P) binding site [chemical binding]; other site 279010000861 catalytic residues [active] 279010000862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000863 D-galactonate transporter; Region: 2A0114; TIGR00893 279010000864 putative substrate translocation pore; other site 279010000865 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 279010000866 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 279010000867 active site 279010000868 tetramer interface [polypeptide binding]; other site 279010000869 Transcriptional regulators [Transcription]; Region: FadR; COG2186 279010000870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010000871 DNA-binding site [nucleotide binding]; DNA binding site 279010000872 FCD domain; Region: FCD; pfam07729 279010000873 galactarate dehydratase; Region: galactar-dH20; TIGR03248 279010000874 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 279010000875 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 279010000876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010000877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010000878 dimer interface [polypeptide binding]; other site 279010000879 phosphorylation site [posttranslational modification] 279010000880 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010000881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000882 ATP binding site [chemical binding]; other site 279010000883 Mg2+ binding site [ion binding]; other site 279010000884 G-X-G motif; other site 279010000885 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010000886 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 279010000887 Walker A/P-loop; other site 279010000888 ATP binding site [chemical binding]; other site 279010000889 Q-loop/lid; other site 279010000890 ABC transporter signature motif; other site 279010000891 Walker B; other site 279010000892 D-loop; other site 279010000893 H-loop/switch region; other site 279010000894 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 279010000895 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 279010000896 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 279010000897 Phosphotransferase enzyme family; Region: APH; pfam01636 279010000898 putative active site [active] 279010000899 putative substrate binding site [chemical binding]; other site 279010000900 ATP binding site [chemical binding]; other site 279010000901 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010000902 MarR family; Region: MarR; pfam01047 279010000903 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 279010000904 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 279010000905 acyl-activating enzyme (AAE) consensus motif; other site 279010000906 AMP binding site [chemical binding]; other site 279010000907 active site 279010000908 CoA binding site [chemical binding]; other site 279010000909 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 279010000910 serpin-like protein; Provisional; Region: PHA02660 279010000911 reactive center loop; other site 279010000912 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 279010000913 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010000914 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010000915 DNA binding residues [nucleotide binding] 279010000916 dimer interface [polypeptide binding]; other site 279010000917 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 279010000918 Predicted transcriptional regulators [Transcription]; Region: COG1695 279010000919 Transcriptional regulator PadR-like family; Region: PadR; cl17335 279010000920 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 279010000921 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 279010000922 dodecamer interface 1 [polypeptide binding]; other site 279010000923 dodecamer interface 2 [polypeptide binding]; other site 279010000924 trimer interface [polypeptide binding]; other site 279010000925 TRAP binding interface [polypeptide binding]; other site 279010000926 Zn binding site [ion binding]; other site 279010000927 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 279010000928 EamA-like transporter family; Region: EamA; pfam00892 279010000929 EamA-like transporter family; Region: EamA; pfam00892 279010000930 RDD family; Region: RDD; pfam06271 279010000931 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 279010000932 SEC-C motif; Region: SEC-C; pfam02810 279010000933 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 279010000934 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 279010000935 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 279010000936 Walker A/P-loop; other site 279010000937 ATP binding site [chemical binding]; other site 279010000938 Q-loop/lid; other site 279010000939 ABC transporter signature motif; other site 279010000940 Walker B; other site 279010000941 D-loop; other site 279010000942 H-loop/switch region; other site 279010000943 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 279010000944 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010000945 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 279010000946 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010000947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010000948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000949 active site 279010000950 phosphorylation site [posttranslational modification] 279010000951 intermolecular recognition site; other site 279010000952 dimerization interface [polypeptide binding]; other site 279010000953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010000954 DNA binding site [nucleotide binding] 279010000955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010000956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010000957 dimer interface [polypeptide binding]; other site 279010000958 phosphorylation site [posttranslational modification] 279010000959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000960 ATP binding site [chemical binding]; other site 279010000961 Mg2+ binding site [ion binding]; other site 279010000962 G-X-G motif; other site 279010000963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010000964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010000965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010000966 dimerization interface [polypeptide binding]; other site 279010000967 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 279010000968 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279010000969 classical (c) SDRs; Region: SDR_c; cd05233 279010000970 NAD(P) binding site [chemical binding]; other site 279010000971 active site 279010000972 hypothetical protein; Provisional; Region: PRK06922 279010000973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000974 S-adenosylmethionine binding site [chemical binding]; other site 279010000975 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 279010000976 Predicted membrane protein [Function unknown]; Region: COG1288 279010000977 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 279010000978 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010000979 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 279010000980 metal binding site [ion binding]; metal-binding site 279010000981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010000982 Coenzyme A binding pocket [chemical binding]; other site 279010000983 amidase; Provisional; Region: PRK06529 279010000984 Amidase; Region: Amidase; pfam01425 279010000985 oligoendopeptidase F; Region: pepF; TIGR00181 279010000986 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 279010000987 active site 279010000988 Zn binding site [ion binding]; other site 279010000989 Beta-lactamase; Region: Beta-lactamase; pfam00144 279010000990 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279010000991 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 279010000992 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 279010000993 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 279010000994 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 279010000995 Cysteine-rich domain; Region: CCG; pfam02754 279010000996 Cysteine-rich domain; Region: CCG; pfam02754 279010000997 FAD binding domain; Region: FAD_binding_4; pfam01565 279010000998 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 279010000999 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010001000 active site 279010001001 P-loop; other site 279010001002 phosphorylation site [posttranslational modification] 279010001003 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 279010001004 methionine cluster; other site 279010001005 active site 279010001006 phosphorylation site [posttranslational modification] 279010001007 metal binding site [ion binding]; metal-binding site 279010001008 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010001009 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 279010001010 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 279010001011 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 279010001012 NAD binding site [chemical binding]; other site 279010001013 sugar binding site [chemical binding]; other site 279010001014 divalent metal binding site [ion binding]; other site 279010001015 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010001016 dimer interface [polypeptide binding]; other site 279010001017 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010001018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001019 DNA-binding site [nucleotide binding]; DNA binding site 279010001020 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 279010001021 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 279010001022 putative active site [active] 279010001023 YdjC motif; other site 279010001024 Mg binding site [ion binding]; other site 279010001025 putative homodimer interface [polypeptide binding]; other site 279010001026 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 279010001027 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 279010001028 active site 279010001029 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010001030 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 279010001031 Interdomain contacts; other site 279010001032 Cytokine receptor motif; other site 279010001033 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 279010001034 aromatic chitin/cellulose binding site residues [chemical binding]; other site 279010001035 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 279010001036 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 279010001037 active site 279010001038 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 279010001039 Chitinase C; Region: ChiC; pfam06483 279010001040 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 279010001041 glucose-1-dehydrogenase; Provisional; Region: PRK08936 279010001042 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 279010001043 NAD binding site [chemical binding]; other site 279010001044 homodimer interface [polypeptide binding]; other site 279010001045 active site 279010001046 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 279010001047 Protein of unknown function; Region: DUF3658; pfam12395 279010001048 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 279010001049 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 279010001050 active site residue [active] 279010001051 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 279010001052 active site residue [active] 279010001053 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 279010001054 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 279010001055 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 279010001056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 279010001057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 279010001058 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010001059 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010001060 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010001061 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010001062 Walker A/P-loop; other site 279010001063 ATP binding site [chemical binding]; other site 279010001064 Q-loop/lid; other site 279010001065 ABC transporter signature motif; other site 279010001066 Walker B; other site 279010001067 D-loop; other site 279010001068 H-loop/switch region; other site 279010001069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010001070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010001071 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 279010001072 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 279010001073 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 279010001074 Predicted transcriptional regulators [Transcription]; Region: COG1695 279010001075 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 279010001076 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 279010001077 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 279010001078 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 279010001079 putative metal binding site [ion binding]; other site 279010001080 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 279010001081 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 279010001082 putative metal binding site [ion binding]; other site 279010001083 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 279010001084 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 279010001085 putative metal binding site [ion binding]; other site 279010001086 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 279010001087 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 279010001088 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 279010001089 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 279010001090 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 279010001091 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 279010001092 CAAX protease self-immunity; Region: Abi; pfam02517 279010001093 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010001094 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010001095 DNA binding residues [nucleotide binding] 279010001096 dimer interface [polypeptide binding]; other site 279010001097 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 279010001098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001099 putative substrate translocation pore; other site 279010001100 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 279010001101 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 279010001102 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010001103 NAD binding site [chemical binding]; other site 279010001104 dimer interface [polypeptide binding]; other site 279010001105 substrate binding site [chemical binding]; other site 279010001106 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 279010001107 L-lactate permease; Region: Lactate_perm; pfam02652 279010001108 LysE type translocator; Region: LysE; pfam01810 279010001109 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279010001110 Spore germination protein; Region: Spore_permease; cl17796 279010001111 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 279010001112 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 279010001113 homodimer interface [polypeptide binding]; other site 279010001114 NAD binding pocket [chemical binding]; other site 279010001115 ATP binding pocket [chemical binding]; other site 279010001116 Mg binding site [ion binding]; other site 279010001117 active-site loop [active] 279010001118 shikimate kinase; Reviewed; Region: aroK; PRK00131 279010001119 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 279010001120 ADP binding site [chemical binding]; other site 279010001121 magnesium binding site [ion binding]; other site 279010001122 putative shikimate binding site; other site 279010001123 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 279010001124 Proline dehydrogenase; Region: Pro_dh; pfam01619 279010001125 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 279010001126 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 279010001127 Glutamate binding site [chemical binding]; other site 279010001128 homodimer interface [polypeptide binding]; other site 279010001129 NAD binding site [chemical binding]; other site 279010001130 catalytic residues [active] 279010001131 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 279010001132 Na binding site [ion binding]; other site 279010001133 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010001134 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 279010001135 Predicted membrane protein [Function unknown]; Region: COG3689 279010001136 Predicted permeases [General function prediction only]; Region: COG0701 279010001137 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 279010001138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010001139 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010001140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010001141 putative Zn2+ binding site [ion binding]; other site 279010001142 putative DNA binding site [nucleotide binding]; other site 279010001143 hypothetical protein; Provisional; Region: PRK09272 279010001144 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 279010001145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001146 dimer interface [polypeptide binding]; other site 279010001147 conserved gate region; other site 279010001148 putative PBP binding loops; other site 279010001149 ABC-ATPase subunit interface; other site 279010001150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 279010001151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010001152 substrate binding pocket [chemical binding]; other site 279010001153 membrane-bound complex binding site; other site 279010001154 hinge residues; other site 279010001155 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 279010001156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010001157 Predicted ATPase [General function prediction only]; Region: COG3910 279010001158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010001159 Walker A/P-loop; other site 279010001160 ATP binding site [chemical binding]; other site 279010001161 Q-loop/lid; other site 279010001162 ABC transporter signature motif; other site 279010001163 Walker B; other site 279010001164 D-loop; other site 279010001165 H-loop/switch region; other site 279010001166 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 279010001167 beta-galactosidase; Region: BGL; TIGR03356 279010001168 Competence protein J (ComJ); Region: ComJ; pfam11033 279010001169 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 279010001170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 279010001171 Catalytic domain of Protein Kinases; Region: PKc; cd00180 279010001172 active site 279010001173 ATP binding site [chemical binding]; other site 279010001174 substrate binding site [chemical binding]; other site 279010001175 activation loop (A-loop); other site 279010001176 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010001177 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 279010001178 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 279010001179 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 279010001180 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 279010001181 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 279010001182 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 279010001183 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 279010001184 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 279010001185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010001186 Walker A/P-loop; other site 279010001187 ATP binding site [chemical binding]; other site 279010001188 Q-loop/lid; other site 279010001189 ABC transporter signature motif; other site 279010001190 Walker B; other site 279010001191 D-loop; other site 279010001192 H-loop/switch region; other site 279010001193 TOBE domain; Region: TOBE_2; pfam08402 279010001194 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 279010001195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001196 dimer interface [polypeptide binding]; other site 279010001197 conserved gate region; other site 279010001198 putative PBP binding loops; other site 279010001199 ABC-ATPase subunit interface; other site 279010001200 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 279010001201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001202 dimer interface [polypeptide binding]; other site 279010001203 conserved gate region; other site 279010001204 putative PBP binding loops; other site 279010001205 ABC-ATPase subunit interface; other site 279010001206 Condensation domain; Region: Condensation; pfam00668 279010001207 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001208 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001209 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 279010001210 acyl-activating enzyme (AAE) consensus motif; other site 279010001211 AMP binding site [chemical binding]; other site 279010001212 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001213 Condensation domain; Region: Condensation; pfam00668 279010001214 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001215 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001216 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 279010001217 acyl-activating enzyme (AAE) consensus motif; other site 279010001218 AMP binding site [chemical binding]; other site 279010001219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001220 Condensation domain; Region: Condensation; pfam00668 279010001221 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001222 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001223 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 279010001224 acyl-activating enzyme (AAE) consensus motif; other site 279010001225 AMP binding site [chemical binding]; other site 279010001226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001227 Condensation domain; Region: Condensation; pfam00668 279010001228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001229 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 279010001230 Condensation domain; Region: Condensation; pfam00668 279010001231 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001232 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 279010001233 acyl-activating enzyme (AAE) consensus motif; other site 279010001234 AMP binding site [chemical binding]; other site 279010001235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001236 Condensation domain; Region: Condensation; pfam00668 279010001237 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001238 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001239 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 279010001240 acyl-activating enzyme (AAE) consensus motif; other site 279010001241 AMP binding site [chemical binding]; other site 279010001242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001243 Condensation domain; Region: Condensation; pfam00668 279010001244 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001245 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001246 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 279010001247 acyl-activating enzyme (AAE) consensus motif; other site 279010001248 AMP binding site [chemical binding]; other site 279010001249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001250 Condensation domain; Region: Condensation; pfam00668 279010001251 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001252 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 279010001253 Condensation domain; Region: Condensation; pfam00668 279010001254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 279010001255 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 279010001256 acyl-activating enzyme (AAE) consensus motif; other site 279010001257 AMP binding site [chemical binding]; other site 279010001258 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010001259 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 279010001260 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 279010001261 EamA-like transporter family; Region: EamA; pfam00892 279010001262 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010001263 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010001264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001265 DNA-binding site [nucleotide binding]; DNA binding site 279010001266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010001267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001268 homodimer interface [polypeptide binding]; other site 279010001269 catalytic residue [active] 279010001270 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 279010001271 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 279010001272 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 279010001273 Putative esterase; Region: Esterase; pfam00756 279010001274 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010001275 Predicted membrane protein [Function unknown]; Region: COG2364 279010001276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010001277 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 279010001278 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010001279 Walker A/P-loop; other site 279010001280 ATP binding site [chemical binding]; other site 279010001281 Q-loop/lid; other site 279010001282 ABC transporter signature motif; other site 279010001283 Walker B; other site 279010001284 D-loop; other site 279010001285 H-loop/switch region; other site 279010001286 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 279010001287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010001288 catalytic residue [active] 279010001289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001290 dimerization interface [polypeptide binding]; other site 279010001291 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010001292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001293 dimer interface [polypeptide binding]; other site 279010001294 putative CheW interface [polypeptide binding]; other site 279010001295 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 279010001296 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 279010001297 Walker A/P-loop; other site 279010001298 ATP binding site [chemical binding]; other site 279010001299 Q-loop/lid; other site 279010001300 ABC transporter signature motif; other site 279010001301 Walker B; other site 279010001302 D-loop; other site 279010001303 H-loop/switch region; other site 279010001304 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 279010001305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001306 dimer interface [polypeptide binding]; other site 279010001307 conserved gate region; other site 279010001308 putative PBP binding loops; other site 279010001309 ABC-ATPase subunit interface; other site 279010001310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 279010001311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010001312 substrate binding pocket [chemical binding]; other site 279010001313 membrane-bound complex binding site; other site 279010001314 hinge residues; other site 279010001315 PAS fold; Region: PAS; pfam00989 279010001316 PAS domain; Region: PAS; smart00091 279010001317 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 279010001318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010001319 Walker A motif; other site 279010001320 ATP binding site [chemical binding]; other site 279010001321 Walker B motif; other site 279010001322 arginine finger; other site 279010001323 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 279010001324 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 279010001325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010001326 inhibitor-cofactor binding pocket; inhibition site 279010001327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001328 catalytic residue [active] 279010001329 S-methylmethionine transporter; Provisional; Region: PRK11387 279010001330 Arginase family; Region: Arginase; cd09989 279010001331 agmatinase; Region: agmatinase; TIGR01230 279010001332 active site 279010001333 Mn binding site [ion binding]; other site 279010001334 oligomer interface [polypeptide binding]; other site 279010001335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010001336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010001337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010001338 dimerization interface [polypeptide binding]; other site 279010001339 aromatic acid decarboxylase; Validated; Region: PRK05920 279010001340 Flavoprotein; Region: Flavoprotein; pfam02441 279010001341 UbiD family decarboxylase; Region: TIGR00148 279010001342 50S ribosomal protein L37Ae; Reviewed; Region: rpl37ae; PRK03976 279010001343 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 279010001344 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010001345 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 279010001346 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 279010001347 ligand binding site [chemical binding]; other site 279010001348 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 279010001349 Cache domain; Region: Cache_1; pfam02743 279010001350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001351 dimerization interface [polypeptide binding]; other site 279010001352 Histidine kinase; Region: His_kinase; pfam06580 279010001353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001354 ATP binding site [chemical binding]; other site 279010001355 Mg2+ binding site [ion binding]; other site 279010001356 G-X-G motif; other site 279010001357 Response regulator receiver domain; Region: Response_reg; pfam00072 279010001358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001359 active site 279010001360 phosphorylation site [posttranslational modification] 279010001361 intermolecular recognition site; other site 279010001362 dimerization interface [polypeptide binding]; other site 279010001363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010001364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010001365 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 279010001366 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 279010001367 putative ligand binding site [chemical binding]; other site 279010001368 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 279010001369 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 279010001370 Walker A/P-loop; other site 279010001371 ATP binding site [chemical binding]; other site 279010001372 Q-loop/lid; other site 279010001373 ABC transporter signature motif; other site 279010001374 Walker B; other site 279010001375 D-loop; other site 279010001376 H-loop/switch region; other site 279010001377 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 279010001378 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 279010001379 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 279010001380 TM-ABC transporter signature motif; other site 279010001381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010001383 putative substrate translocation pore; other site 279010001384 Transcriptional regulators [Transcription]; Region: MarR; COG1846 279010001385 MarR family; Region: MarR; pfam01047 279010001386 MarR family; Region: MarR_2; cl17246 279010001387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010001388 Coenzyme A binding pocket [chemical binding]; other site 279010001389 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 279010001390 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 279010001391 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 279010001392 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 279010001393 Phytase; Region: Phytase; cl17685 279010001394 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 279010001395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001396 putative substrate translocation pore; other site 279010001397 POT family; Region: PTR2; pfam00854 279010001398 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279010001399 Right handed beta helix region; Region: Beta_helix; pfam13229 279010001400 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 279010001401 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010001402 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 279010001403 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 279010001404 Spore germination protein; Region: Spore_permease; pfam03845 279010001405 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010001406 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010001407 DNA binding residues [nucleotide binding] 279010001408 dimer interface [polypeptide binding]; other site 279010001409 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010001410 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279010001411 Walker A/P-loop; other site 279010001412 ATP binding site [chemical binding]; other site 279010001413 Q-loop/lid; other site 279010001414 ABC transporter signature motif; other site 279010001415 Walker B; other site 279010001416 D-loop; other site 279010001417 H-loop/switch region; other site 279010001418 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279010001419 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010001420 FtsX-like permease family; Region: FtsX; pfam02687 279010001421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010001422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001423 active site 279010001424 phosphorylation site [posttranslational modification] 279010001425 intermolecular recognition site; other site 279010001426 dimerization interface [polypeptide binding]; other site 279010001427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010001428 DNA binding site [nucleotide binding] 279010001429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010001430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001431 dimerization interface [polypeptide binding]; other site 279010001432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010001433 dimer interface [polypeptide binding]; other site 279010001434 phosphorylation site [posttranslational modification] 279010001435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001436 ATP binding site [chemical binding]; other site 279010001437 Mg2+ binding site [ion binding]; other site 279010001438 G-X-G motif; other site 279010001439 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 279010001440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001441 dimerization interface [polypeptide binding]; other site 279010001442 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010001443 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001444 dimer interface [polypeptide binding]; other site 279010001445 putative CheW interface [polypeptide binding]; other site 279010001446 aspartate kinase; Reviewed; Region: PRK09034 279010001447 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 279010001448 putative catalytic residues [active] 279010001449 putative nucleotide binding site [chemical binding]; other site 279010001450 putative aspartate binding site [chemical binding]; other site 279010001451 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 279010001452 allosteric regulatory residue; other site 279010001453 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 279010001454 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 279010001455 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010001456 ABC-ATPase subunit interface; other site 279010001457 dimer interface [polypeptide binding]; other site 279010001458 putative PBP binding regions; other site 279010001459 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010001460 ABC-ATPase subunit interface; other site 279010001461 dimer interface [polypeptide binding]; other site 279010001462 putative PBP binding regions; other site 279010001463 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 279010001464 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010001465 Walker A/P-loop; other site 279010001466 ATP binding site [chemical binding]; other site 279010001467 Q-loop/lid; other site 279010001468 ABC transporter signature motif; other site 279010001469 Walker B; other site 279010001470 D-loop; other site 279010001471 H-loop/switch region; other site 279010001472 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 279010001473 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 279010001474 putative ligand binding residues [chemical binding]; other site 279010001475 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010001476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001477 putative substrate translocation pore; other site 279010001478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010001480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010001481 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 279010001482 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 279010001483 tetramer interface [polypeptide binding]; other site 279010001484 active site 279010001485 Mg2+/Mn2+ binding site [ion binding]; other site 279010001486 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 279010001487 dimer interface [polypeptide binding]; other site 279010001488 FMN binding site [chemical binding]; other site 279010001489 NADPH bind site [chemical binding]; other site 279010001490 Uncharacterized conserved protein [Function unknown]; Region: COG1359 279010001491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010001492 dimerization interface [polypeptide binding]; other site 279010001493 putative DNA binding site [nucleotide binding]; other site 279010001494 putative Zn2+ binding site [ion binding]; other site 279010001495 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010001496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001497 DNA-binding site [nucleotide binding]; DNA binding site 279010001498 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010001499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001500 homodimer interface [polypeptide binding]; other site 279010001501 catalytic residue [active] 279010001502 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 279010001503 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010001504 inhibitor-cofactor binding pocket; inhibition site 279010001505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001506 catalytic residue [active] 279010001507 amino acid transporter; Region: 2A0306; TIGR00909 279010001508 succinic semialdehyde dehydrogenase; Region: PLN02278 279010001509 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 279010001510 tetramerization interface [polypeptide binding]; other site 279010001511 NAD(P) binding site [chemical binding]; other site 279010001512 catalytic residues [active] 279010001513 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010001514 EamA-like transporter family; Region: EamA; pfam00892 279010001515 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 279010001516 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 279010001517 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 279010001518 YtkA-like; Region: YtkA; pfam13115 279010001519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010001520 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 279010001521 NosL; Region: NosL; cl01769 279010001522 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 279010001523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010001524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010001525 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 279010001526 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 279010001527 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010001528 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 279010001529 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 279010001530 [4Fe-4S] binding site [ion binding]; other site 279010001531 molybdopterin cofactor binding site; other site 279010001532 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 279010001533 molybdopterin cofactor binding site; other site 279010001534 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 279010001535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010001536 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 279010001537 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 279010001538 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010001539 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 279010001540 [2Fe-2S] cluster binding site [ion binding]; other site 279010001541 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 279010001542 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 279010001543 active site 279010001544 SAM binding site [chemical binding]; other site 279010001545 homodimer interface [polypeptide binding]; other site 279010001546 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010001547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001548 DNA-binding site [nucleotide binding]; DNA binding site 279010001549 FCD domain; Region: FCD; pfam07729 279010001550 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279010001551 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 279010001552 transmembrane helices; other site 279010001553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 279010001554 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 279010001555 dimer interface [polypeptide binding]; other site 279010001556 active site 2 [active] 279010001557 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 279010001558 homodimer interaction site [polypeptide binding]; other site 279010001559 cofactor binding site; other site 279010001560 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010001561 PRD domain; Region: PRD; pfam00874 279010001562 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010001563 active site 279010001564 P-loop; other site 279010001565 phosphorylation site [posttranslational modification] 279010001566 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010001567 active site 279010001568 phosphorylation site [posttranslational modification] 279010001569 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 279010001570 active site 279010001571 P-loop; other site 279010001572 phosphorylation site [posttranslational modification] 279010001573 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 279010001574 transketolase; Reviewed; Region: PRK05899 279010001575 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 279010001576 TPP-binding site [chemical binding]; other site 279010001577 dimer interface [polypeptide binding]; other site 279010001578 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 279010001579 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279010001580 PYR/PP interface [polypeptide binding]; other site 279010001581 dimer interface [polypeptide binding]; other site 279010001582 TPP binding site [chemical binding]; other site 279010001583 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010001584 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 279010001585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010001586 active site 279010001587 motif I; other site 279010001588 motif II; other site 279010001589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010001590 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 279010001591 putative active site [active] 279010001592 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 279010001593 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 279010001594 hypothetical protein; Provisional; Region: PRK05463 279010001595 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 279010001596 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 279010001597 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 279010001598 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 279010001599 Transcriptional regulator [Transcription]; Region: IclR; COG1414 279010001600 Bacterial transcriptional regulator; Region: IclR; pfam01614 279010001601 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 279010001602 active site 279010001603 catalytic triad [active] 279010001604 oxyanion hole [active] 279010001605 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 279010001606 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 279010001607 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 279010001608 active site 279010001609 P-loop; other site 279010001610 phosphorylation site [posttranslational modification] 279010001611 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010001612 active site 279010001613 phosphorylation site [posttranslational modification] 279010001614 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 279010001615 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 279010001616 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 279010001617 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010001618 HTH domain; Region: HTH_11; pfam08279 279010001619 HTH domain; Region: HTH_11; cl17392 279010001620 PRD domain; Region: PRD; pfam00874 279010001621 PRD domain; Region: PRD; pfam00874 279010001622 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010001623 active site 279010001624 P-loop; other site 279010001625 phosphorylation site [posttranslational modification] 279010001626 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 279010001627 short chain dehydrogenase; Provisional; Region: PRK06701 279010001628 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279010001629 NAD binding site [chemical binding]; other site 279010001630 metal binding site [ion binding]; metal-binding site 279010001631 active site 279010001632 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 279010001633 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 279010001634 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 279010001635 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 279010001636 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 279010001637 Transcriptional regulator [Transcription]; Region: LytR; COG1316 279010001638 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 279010001639 Uncharacterized conserved protein [Function unknown]; Region: COG2128 279010001640 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 279010001641 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 279010001642 AsnC family; Region: AsnC_trans_reg; pfam01037 279010001643 DNA topoisomerase III; Provisional; Region: PRK07726 279010001644 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 279010001645 active site 279010001646 putative interdomain interaction site [polypeptide binding]; other site 279010001647 putative metal-binding site [ion binding]; other site 279010001648 putative nucleotide binding site [chemical binding]; other site 279010001649 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 279010001650 domain I; other site 279010001651 DNA binding groove [nucleotide binding] 279010001652 phosphate binding site [ion binding]; other site 279010001653 domain II; other site 279010001654 domain III; other site 279010001655 nucleotide binding site [chemical binding]; other site 279010001656 catalytic site [active] 279010001657 domain IV; other site 279010001658 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 279010001659 Amino acid permease; Region: AA_permease_2; pfam13520 279010001660 pyruvate oxidase; Provisional; Region: PRK08611 279010001661 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 279010001662 PYR/PP interface [polypeptide binding]; other site 279010001663 tetramer interface [polypeptide binding]; other site 279010001664 dimer interface [polypeptide binding]; other site 279010001665 TPP binding site [chemical binding]; other site 279010001666 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279010001667 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 279010001668 TPP-binding site [chemical binding]; other site 279010001669 Chitin binding domain; Region: Chitin_bind_3; pfam03067 279010001670 Transposase; Region: HTH_Tnp_1; cl17663 279010001671 putative transposase OrfB; Reviewed; Region: PHA02517 279010001672 HTH-like domain; Region: HTH_21; pfam13276 279010001673 Integrase core domain; Region: rve; pfam00665 279010001674 Integrase core domain; Region: rve_3; pfam13683 279010001675 Homeodomain-like domain; Region: HTH_23; pfam13384 279010001676 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010001678 manganese transport protein MntH; Reviewed; Region: PRK00701 279010001679 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 279010001680 aspartate ammonia-lyase; Provisional; Region: PRK14515 279010001681 Aspartase; Region: Aspartase; cd01357 279010001682 active sites [active] 279010001683 tetramer interface [polypeptide binding]; other site 279010001684 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 279010001685 glycosyltransferase, MGT family; Region: MGT; TIGR01426 279010001686 active site 279010001687 TDP-binding site; other site 279010001688 acceptor substrate-binding pocket; other site 279010001689 homodimer interface [polypeptide binding]; other site 279010001690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 279010001691 EcsC protein family; Region: EcsC; pfam12787 279010001692 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 279010001693 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 279010001694 General stress protein [General function prediction only]; Region: GsiB; COG3729 279010001695 General stress protein [General function prediction only]; Region: GsiB; COG3729 279010001696 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 279010001697 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010001698 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010001699 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 279010001700 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010001701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010001702 Walker A/P-loop; other site 279010001703 ATP binding site [chemical binding]; other site 279010001704 Q-loop/lid; other site 279010001705 ABC transporter signature motif; other site 279010001706 Walker B; other site 279010001707 D-loop; other site 279010001708 H-loop/switch region; other site 279010001709 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 279010001710 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010001711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010001712 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 279010001713 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 279010001714 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 279010001715 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010001716 catalytic residues [active] 279010001717 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 279010001718 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 279010001719 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 279010001720 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 279010001721 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279010001722 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010001723 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010001724 Esterase/lipase [General function prediction only]; Region: COG1647 279010001725 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 279010001726 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010001727 ATP binding site [chemical binding]; other site 279010001728 Mg++ binding site [ion binding]; other site 279010001729 motif III; other site 279010001730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010001731 nucleotide binding region [chemical binding]; other site 279010001732 ATP-binding site [chemical binding]; other site 279010001733 Uncharacterized conserved protein [Function unknown]; Region: COG3402 279010001734 Predicted membrane protein [Function unknown]; Region: COG3428 279010001735 Bacterial PH domain; Region: DUF304; pfam03703 279010001736 Bacterial PH domain; Region: DUF304; pfam03703 279010001737 Bacterial PH domain; Region: DUF304; pfam03703 279010001738 Rhomboid family; Region: Rhomboid; pfam01694 279010001739 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 279010001740 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 279010001741 alanine racemase; Region: alr; TIGR00492 279010001742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 279010001743 active site 279010001744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010001745 dimer interface [polypeptide binding]; other site 279010001746 substrate binding site [chemical binding]; other site 279010001747 catalytic residues [active] 279010001748 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 279010001749 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 279010001750 Rsbr N terminal; Region: Rsbr_N; pfam08678 279010001751 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 279010001752 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 279010001753 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279010001754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001755 ATP binding site [chemical binding]; other site 279010001756 Mg2+ binding site [ion binding]; other site 279010001757 G-X-G motif; other site 279010001758 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 279010001759 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 279010001760 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 279010001761 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 279010001762 anti sigma factor interaction site; other site 279010001763 regulatory phosphorylation site [posttranslational modification]; other site 279010001764 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279010001765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001766 ATP binding site [chemical binding]; other site 279010001767 Mg2+ binding site [ion binding]; other site 279010001768 G-X-G motif; other site 279010001769 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 279010001770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010001771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010001772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010001773 DNA binding residues [nucleotide binding] 279010001774 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 279010001775 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 279010001776 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 279010001777 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 279010001778 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 279010001779 RNA binding site [nucleotide binding]; other site 279010001780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010001781 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279010001782 MMPL family; Region: MMPL; pfam03176 279010001783 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 279010001784 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 279010001785 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 279010001786 hypothetical protein; Provisional; Region: PRK04351 279010001787 SprT homologues; Region: SprT; cl01182 279010001788 EamA-like transporter family; Region: EamA; pfam00892 279010001789 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010001790 EamA-like transporter family; Region: EamA; pfam00892 279010001791 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010001792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010001793 non-specific DNA binding site [nucleotide binding]; other site 279010001794 salt bridge; other site 279010001795 sequence-specific DNA binding site [nucleotide binding]; other site 279010001796 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 279010001797 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 279010001798 putative di-iron ligands [ion binding]; other site 279010001799 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 279010001800 DNA-binding site [nucleotide binding]; DNA binding site 279010001801 RNA-binding motif; other site 279010001802 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 279010001803 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 279010001804 NADP binding site [chemical binding]; other site 279010001805 dimer interface [polypeptide binding]; other site 279010001806 Predicted membrane protein [Function unknown]; Region: COG2364 279010001807 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010001808 MarR family; Region: MarR; pfam01047 279010001809 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279010001810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010001811 Coenzyme A binding pocket [chemical binding]; other site 279010001812 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 279010001813 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 279010001814 active site 279010001815 Mn binding site [ion binding]; other site 279010001816 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010001817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010001818 dimerization interface [polypeptide binding]; other site 279010001819 putative DNA binding site [nucleotide binding]; other site 279010001820 putative Zn2+ binding site [ion binding]; other site 279010001821 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010001822 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010001823 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010001824 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010001825 LysE type translocator; Region: LysE; cl00565 279010001826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010001827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010001828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010001829 dimerization interface [polypeptide binding]; other site 279010001830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001831 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010001832 putative substrate translocation pore; other site 279010001833 Putative cyclase; Region: Cyclase; pfam04199 279010001834 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279010001835 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 279010001836 Yip1 domain; Region: Yip1; pfam04893 279010001837 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 279010001838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010001839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010001840 DNA binding residues [nucleotide binding] 279010001841 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010001842 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 279010001843 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 279010001844 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 279010001845 catalytic triad [active] 279010001846 catalytic triad [active] 279010001847 oxyanion hole [active] 279010001848 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 279010001849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001850 putative substrate translocation pore; other site 279010001851 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 279010001852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010001853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010001854 dimer interface [polypeptide binding]; other site 279010001855 phosphorylation site [posttranslational modification] 279010001856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001857 ATP binding site [chemical binding]; other site 279010001858 Mg2+ binding site [ion binding]; other site 279010001859 G-X-G motif; other site 279010001860 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 279010001861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001862 active site 279010001863 phosphorylation site [posttranslational modification] 279010001864 intermolecular recognition site; other site 279010001865 dimerization interface [polypeptide binding]; other site 279010001866 Histidine kinase; Region: His_kinase; pfam06580 279010001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001868 ATP binding site [chemical binding]; other site 279010001869 Mg2+ binding site [ion binding]; other site 279010001870 G-X-G motif; other site 279010001871 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 279010001872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001873 active site 279010001874 phosphorylation site [posttranslational modification] 279010001875 intermolecular recognition site; other site 279010001876 dimerization interface [polypeptide binding]; other site 279010001877 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 279010001878 DNA binding site [nucleotide binding] 279010001879 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 279010001880 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001881 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001882 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001883 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001884 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001885 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001886 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001887 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 279010001888 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001889 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001890 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001891 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001892 Cna protein B-type domain; Region: Cna_B; pfam05738 279010001893 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 279010001894 active site 279010001895 catalytic site [active] 279010001896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001897 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279010001898 putative substrate translocation pore; other site 279010001899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001900 thiamine monophosphate kinase; Provisional; Region: PRK05731 279010001901 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 279010001902 ATP binding site [chemical binding]; other site 279010001903 dimerization interface [polypeptide binding]; other site 279010001904 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 279010001905 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 279010001906 Glycoprotease family; Region: Peptidase_M22; pfam00814 279010001907 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 279010001908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010001909 Coenzyme A binding pocket [chemical binding]; other site 279010001910 UGMP family protein; Validated; Region: PRK09604 279010001911 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 279010001912 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010001913 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010001914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010001915 ABC transporter; Region: ABC_tran_2; pfam12848 279010001916 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010001917 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 279010001918 trimer interface [polypeptide binding]; other site 279010001919 dimer interface [polypeptide binding]; other site 279010001920 putative active site [active] 279010001921 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 279010001922 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 279010001923 CoA binding domain; Region: CoA_binding; pfam02629 279010001924 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 279010001925 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 279010001926 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 279010001927 CAAX protease self-immunity; Region: Abi; pfam02517 279010001928 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 279010001929 oligomerisation interface [polypeptide binding]; other site 279010001930 mobile loop; other site 279010001931 roof hairpin; other site 279010001932 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 279010001933 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 279010001934 ring oligomerisation interface [polypeptide binding]; other site 279010001935 ATP/Mg binding site [chemical binding]; other site 279010001936 stacking interactions; other site 279010001937 hinge regions; other site 279010001938 YolD-like protein; Region: YolD; pfam08863 279010001939 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 279010001940 VanW like protein; Region: VanW; pfam04294 279010001941 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 279010001942 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010001943 Coenzyme A binding pocket [chemical binding]; other site 279010001944 Uncharacterized conserved protein [Function unknown]; Region: COG2135 279010001945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010001946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010001947 phosphoenolpyruvate synthase; Validated; Region: PRK06241 279010001948 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279010001949 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 279010001950 Uncharacterized conserved protein [Function unknown]; Region: COG3189 279010001951 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 279010001952 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 279010001953 putative NAD(P) binding site [chemical binding]; other site 279010001954 active site 279010001955 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 279010001956 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 279010001957 substrate binding pocket [chemical binding]; other site 279010001958 catalytic triad [active] 279010001959 D-galactonate transporter; Region: 2A0114; TIGR00893 279010001960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001961 putative substrate translocation pore; other site 279010001962 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 279010001963 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 279010001964 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 279010001965 Repair protein; Region: Repair_PSII; pfam04536 279010001966 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 279010001967 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 279010001968 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279010001969 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 279010001970 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 279010001971 Predicted transcriptional regulators [Transcription]; Region: COG1378 279010001972 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 279010001973 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 279010001974 C-terminal domain interface [polypeptide binding]; other site 279010001975 sugar binding site [chemical binding]; other site 279010001976 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 279010001977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010001978 sequence-specific DNA binding site [nucleotide binding]; other site 279010001979 salt bridge; other site 279010001980 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 279010001981 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 279010001982 cell division protein FtsW; Region: ftsW; TIGR02614 279010001983 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010001984 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 279010001985 dimer interface [polypeptide binding]; other site 279010001986 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010001987 HTH domain; Region: HTH_11; pfam08279 279010001988 WYL domain; Region: WYL; pfam13280 279010001989 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010001990 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 279010001991 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010001992 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279010001993 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 279010001994 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 279010001995 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 279010001996 active site 279010001997 Na/Ca binding site [ion binding]; other site 279010001998 catalytic site [active] 279010001999 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 279010002000 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010002001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010002002 DNA binding site [nucleotide binding] 279010002003 domain linker motif; other site 279010002004 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279010002005 ligand binding site [chemical binding]; other site 279010002006 dimerization interface [polypeptide binding]; other site 279010002007 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 279010002008 homodimer interface [polypeptide binding]; other site 279010002009 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 279010002010 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 279010002011 active site 279010002012 homodimer interface [polypeptide binding]; other site 279010002013 catalytic site [active] 279010002014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010002015 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 279010002016 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 279010002017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002018 dimer interface [polypeptide binding]; other site 279010002019 conserved gate region; other site 279010002020 putative PBP binding loops; other site 279010002021 ABC-ATPase subunit interface; other site 279010002022 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010002023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002024 dimer interface [polypeptide binding]; other site 279010002025 conserved gate region; other site 279010002026 putative PBP binding loops; other site 279010002027 ABC-ATPase subunit interface; other site 279010002028 Predicted integral membrane protein [Function unknown]; Region: COG5521 279010002029 maltose phosphorylase; Provisional; Region: PRK13807 279010002030 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 279010002031 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 279010002032 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 279010002033 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279010002034 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279010002035 Ca binding site [ion binding]; other site 279010002036 active site 279010002037 catalytic site [active] 279010002038 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 279010002039 beta-phosphoglucomutase; Region: bPGM; TIGR01990 279010002040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010002041 motif II; other site 279010002042 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 279010002043 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 279010002044 active site 279010002045 HIGH motif; other site 279010002046 dimer interface [polypeptide binding]; other site 279010002047 KMSKS motif; other site 279010002048 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010002049 RNA binding surface [nucleotide binding]; other site 279010002050 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010002051 MarR family; Region: MarR; pfam01047 279010002052 anti-sigma E factor; Provisional; Region: rseB; PRK09455 279010002053 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 279010002054 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 279010002055 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 279010002056 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279010002057 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 279010002058 Catalytic site [active] 279010002059 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 279010002060 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010002061 NAD(P) binding site [chemical binding]; other site 279010002062 putative active site [active] 279010002063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010002064 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010002065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010002066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 279010002067 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 279010002068 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 279010002069 Multicopper oxidase; Region: Cu-oxidase; pfam00394 279010002070 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 279010002071 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 279010002072 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279010002073 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 279010002074 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 279010002075 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 279010002076 MoxR-like ATPases [General function prediction only]; Region: COG0714 279010002077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010002078 Walker A motif; other site 279010002079 ATP binding site [chemical binding]; other site 279010002080 Walker B motif; other site 279010002081 arginine finger; other site 279010002082 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 279010002083 Protein of unknown function DUF58; Region: DUF58; pfam01882 279010002084 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 279010002085 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 279010002086 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 279010002087 GMP synthase; Reviewed; Region: guaA; PRK00074 279010002088 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 279010002089 AMP/PPi binding site [chemical binding]; other site 279010002090 candidate oxyanion hole; other site 279010002091 catalytic triad [active] 279010002092 potential glutamine specificity residues [chemical binding]; other site 279010002093 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 279010002094 ATP Binding subdomain [chemical binding]; other site 279010002095 Ligand Binding sites [chemical binding]; other site 279010002096 Dimerization subdomain; other site 279010002097 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 279010002098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 279010002099 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010002100 NETI protein; Region: NETI; pfam14044 279010002101 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 279010002102 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 279010002103 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 279010002104 ATP-grasp domain; Region: ATP-grasp; pfam02222 279010002105 adenylosuccinate lyase; Provisional; Region: PRK07492 279010002106 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 279010002107 tetramer interface [polypeptide binding]; other site 279010002108 active site 279010002109 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 279010002110 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 279010002111 ATP binding site [chemical binding]; other site 279010002112 active site 279010002113 substrate binding site [chemical binding]; other site 279010002114 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 279010002115 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 279010002116 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 279010002117 putative active site [active] 279010002118 catalytic triad [active] 279010002119 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 279010002120 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 279010002121 dimerization interface [polypeptide binding]; other site 279010002122 ATP binding site [chemical binding]; other site 279010002123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 279010002124 dimerization interface [polypeptide binding]; other site 279010002125 ATP binding site [chemical binding]; other site 279010002126 amidophosphoribosyltransferase; Provisional; Region: PRK07631 279010002127 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 279010002128 active site 279010002129 tetramer interface [polypeptide binding]; other site 279010002130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010002131 active site 279010002132 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 279010002133 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 279010002134 dimerization interface [polypeptide binding]; other site 279010002135 putative ATP binding site [chemical binding]; other site 279010002136 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 279010002137 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 279010002138 active site 279010002139 substrate binding site [chemical binding]; other site 279010002140 cosubstrate binding site; other site 279010002141 catalytic site [active] 279010002142 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 279010002143 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 279010002144 purine monophosphate binding site [chemical binding]; other site 279010002145 dimer interface [polypeptide binding]; other site 279010002146 putative catalytic residues [active] 279010002147 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 279010002148 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 279010002149 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 279010002150 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 279010002151 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 279010002152 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 279010002153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010002155 Cytochrome P450; Region: p450; cl12078 279010002156 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279010002157 ANTAR domain; Region: ANTAR; cl04297 279010002158 Transposase domain (DUF772); Region: DUF772; pfam05598 279010002159 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279010002160 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 279010002161 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 279010002162 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010002163 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 279010002164 active site 279010002165 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 279010002166 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 279010002167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 279010002168 PcrB family; Region: PcrB; pfam01884 279010002169 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 279010002170 substrate binding site [chemical binding]; other site 279010002171 putative active site [active] 279010002172 dimer interface [polypeptide binding]; other site 279010002173 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 279010002174 Part of AAA domain; Region: AAA_19; pfam13245 279010002175 Family description; Region: UvrD_C_2; pfam13538 279010002176 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 279010002177 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 279010002178 nucleotide binding pocket [chemical binding]; other site 279010002179 K-X-D-G motif; other site 279010002180 catalytic site [active] 279010002181 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 279010002182 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 279010002183 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 279010002184 Dimer interface [polypeptide binding]; other site 279010002185 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 279010002186 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 279010002187 putative dimer interface [polypeptide binding]; other site 279010002188 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 279010002189 putative dimer interface [polypeptide binding]; other site 279010002190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 279010002191 DNA-binding site [nucleotide binding]; DNA binding site 279010002192 PRD domain; Region: PRD; pfam00874 279010002193 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 279010002194 Protein of unknown function; Region: YhfT; pfam10797 279010002195 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 279010002196 active site 279010002197 substrate binding pocket [chemical binding]; other site 279010002198 homodimer interaction site [polypeptide binding]; other site 279010002199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010002200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010002201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010002202 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010002203 catalytic residue [active] 279010002204 putative mutase; Provisional; Region: PRK12383 279010002205 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 279010002206 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 279010002207 dimer interface [polypeptide binding]; other site 279010002208 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 279010002209 active site 279010002210 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010002211 substrate binding site [chemical binding]; other site 279010002212 catalytic residue [active] 279010002213 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 279010002214 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 279010002215 active site 279010002216 trimer interface [polypeptide binding]; other site 279010002217 allosteric site; other site 279010002218 active site lid [active] 279010002219 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010002220 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 279010002221 MgtC family; Region: MgtC; pfam02308 279010002222 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 279010002223 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 279010002224 Na binding site [ion binding]; other site 279010002225 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 279010002226 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 279010002227 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 279010002228 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 279010002229 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 279010002230 GatB domain; Region: GatB_Yqey; pfam02637 279010002231 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 279010002232 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 279010002233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010002235 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 279010002236 Protein export membrane protein; Region: SecD_SecF; cl14618 279010002237 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010002238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010002239 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 279010002240 active site 279010002241 dimerization interface [polypeptide binding]; other site 279010002242 putative lipid kinase; Reviewed; Region: PRK13337 279010002243 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 279010002244 TRAM domain; Region: TRAM; pfam01938 279010002245 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 279010002246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002247 S-adenosylmethionine binding site [chemical binding]; other site 279010002248 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010002249 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 279010002250 HsdM N-terminal domain; Region: HsdM_N; pfam12161 279010002251 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 279010002252 Methyltransferase domain; Region: Methyltransf_26; pfam13659 279010002253 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010002254 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 279010002255 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010002256 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 279010002257 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 279010002258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010002259 ATP binding site [chemical binding]; other site 279010002260 putative Mg++ binding site [ion binding]; other site 279010002261 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 279010002262 active site 279010002263 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 279010002264 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002265 active site turn [active] 279010002266 phosphorylation site [posttranslational modification] 279010002267 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010002268 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 279010002269 HPr interaction site; other site 279010002270 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010002271 active site 279010002272 phosphorylation site [posttranslational modification] 279010002273 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 279010002274 beta-galactosidase; Region: BGL; TIGR03356 279010002275 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010002276 CAT RNA binding domain; Region: CAT_RBD; smart01061 279010002277 PRD domain; Region: PRD; pfam00874 279010002278 PRD domain; Region: PRD; pfam00874 279010002279 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002280 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279010002281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002282 S-adenosylmethionine binding site [chemical binding]; other site 279010002283 hypothetical protein; Provisional; Region: PRK12378 279010002284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010002285 non-specific DNA binding site [nucleotide binding]; other site 279010002286 salt bridge; other site 279010002287 sequence-specific DNA binding site [nucleotide binding]; other site 279010002288 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 279010002289 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010002290 NAD(P) binding site [chemical binding]; other site 279010002291 catalytic residues [active] 279010002292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010002293 dimer interface [polypeptide binding]; other site 279010002294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010002295 putative CheW interface [polypeptide binding]; other site 279010002296 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279010002297 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 279010002298 transmembrane helices; other site 279010002299 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010002300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010002301 Walker A/P-loop; other site 279010002302 ATP binding site [chemical binding]; other site 279010002303 Q-loop/lid; other site 279010002304 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002305 ABC transporter signature motif; other site 279010002306 Walker B; other site 279010002307 D-loop; other site 279010002308 ABC transporter; Region: ABC_tran_2; pfam12848 279010002309 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002310 putative GTP cyclohydrolase; Provisional; Region: PRK13674 279010002311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 279010002312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010002313 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 279010002314 G3 box; other site 279010002315 Switch II region; other site 279010002316 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 279010002317 Nucleoside recognition; Region: Gate; pfam07670 279010002318 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279010002319 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 279010002320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 279010002321 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 279010002322 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 279010002323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010002324 inhibitor-cofactor binding pocket; inhibition site 279010002325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002326 catalytic residue [active] 279010002327 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 279010002328 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 279010002329 substrate-cofactor binding pocket; other site 279010002330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002331 catalytic residue [active] 279010002332 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 279010002333 AAA domain; Region: AAA_26; pfam13500 279010002334 biotin synthase; Validated; Region: PRK06256 279010002335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010002336 FeS/SAM binding site; other site 279010002337 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 279010002338 Cytochrome P450; Region: p450; cl12078 279010002339 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279010002340 Ion transport protein; Region: Ion_trans; pfam00520 279010002341 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010002342 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 279010002343 DNA binding residues [nucleotide binding] 279010002344 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002346 putative substrate translocation pore; other site 279010002347 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010002348 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002349 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002350 ABC transporter; Region: ABC_tran_2; pfam12848 279010002351 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 279010002353 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279010002354 ATP binding site [chemical binding]; other site 279010002355 putative Mg++ binding site [ion binding]; other site 279010002356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010002357 nucleotide binding region [chemical binding]; other site 279010002358 ATP-binding site [chemical binding]; other site 279010002359 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 279010002360 Prostaglandin dehydrogenases; Region: PGDH; cd05288 279010002361 NAD(P) binding site [chemical binding]; other site 279010002362 substrate binding site [chemical binding]; other site 279010002363 dimer interface [polypeptide binding]; other site 279010002364 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 279010002365 Heat induced stress protein YflT; Region: YflT; pfam11181 279010002366 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279010002367 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 279010002368 transmembrane helices; other site 279010002369 VanZ like family; Region: VanZ; pfam04892 279010002370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010002371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010002372 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_5; cd06242 279010002373 putative active site [active] 279010002374 Zn binding site [ion binding]; other site 279010002375 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 279010002376 active site 279010002377 dimer interface [polypeptide binding]; other site 279010002378 Predicted integral membrane protein [Function unknown]; Region: COG5658 279010002379 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 279010002380 SdpI/YhfL protein family; Region: SdpI; pfam13630 279010002381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010002382 dimerization interface [polypeptide binding]; other site 279010002383 putative DNA binding site [nucleotide binding]; other site 279010002384 putative Zn2+ binding site [ion binding]; other site 279010002385 acylphosphatase; Provisional; Region: PRK14420 279010002386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 279010002387 MOSC domain; Region: MOSC; pfam03473 279010002388 3-alpha domain; Region: 3-alpha; pfam03475 279010002389 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 279010002390 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 279010002391 active site 279010002392 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010002393 Sulfatase; Region: Sulfatase; pfam00884 279010002394 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 279010002395 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010002396 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010002397 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 279010002398 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002399 active site turn [active] 279010002400 phosphorylation site [posttranslational modification] 279010002401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010002402 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279010002403 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279010002404 Ca binding site [ion binding]; other site 279010002405 active site 279010002406 catalytic site [active] 279010002407 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 279010002408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010002409 DNA-binding site [nucleotide binding]; DNA binding site 279010002410 UTRA domain; Region: UTRA; pfam07702 279010002411 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 279010002412 putative trimer interface [polypeptide binding]; other site 279010002413 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 279010002414 putative trimer interface [polypeptide binding]; other site 279010002415 putative active site [active] 279010002416 putative substrate binding site [chemical binding]; other site 279010002417 putative CoA binding site [chemical binding]; other site 279010002418 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 279010002419 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010002420 inhibitor-cofactor binding pocket; inhibition site 279010002421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002422 catalytic residue [active] 279010002423 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 279010002424 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 279010002425 putative trimer interface [polypeptide binding]; other site 279010002426 putative CoA binding site [chemical binding]; other site 279010002427 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 279010002428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002429 NAD(P) binding site [chemical binding]; other site 279010002430 active site 279010002431 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010002432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010002433 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010002434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010002435 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010002436 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010002437 active site 279010002438 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 279010002439 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 279010002440 putative metal binding site; other site 279010002441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010002442 binding surface 279010002443 TPR motif; other site 279010002444 TPR repeat; Region: TPR_11; pfam13414 279010002445 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 279010002446 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010002447 inhibitor-cofactor binding pocket; inhibition site 279010002448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002449 catalytic residue [active] 279010002450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010002451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010002452 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 279010002453 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 279010002454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002455 NAD(P) binding site [chemical binding]; other site 279010002456 active site 279010002457 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 279010002458 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 279010002459 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 279010002460 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010002461 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010002462 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279010002463 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 279010002464 FMN binding site [chemical binding]; other site 279010002465 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 279010002466 dimer interface [polypeptide binding]; other site 279010002467 FMN binding site [chemical binding]; other site 279010002468 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 279010002469 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 279010002470 active site 279010002471 metal binding site [ion binding]; metal-binding site 279010002472 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010002473 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 279010002474 active site 279010002475 metal binding site [ion binding]; metal-binding site 279010002476 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010002477 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279010002478 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 279010002479 proposed catalytic triad [active] 279010002480 conserved cys residue [active] 279010002481 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 279010002482 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010002483 amino acid carrier protein; Region: agcS; TIGR00835 279010002484 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 279010002485 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279010002486 active site 279010002487 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 279010002488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010002490 putative substrate translocation pore; other site 279010002491 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 279010002492 calcium/proton exchanger (cax); Region: cax; TIGR00378 279010002493 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 279010002494 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 279010002495 YfkD-like protein; Region: YfkD; pfam14167 279010002496 Radical SAM superfamily; Region: Radical_SAM; pfam04055 279010002497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010002498 FeS/SAM binding site; other site 279010002499 YfkB-like domain; Region: YfkB; pfam08756 279010002500 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 279010002501 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 279010002502 NodB motif; other site 279010002503 active site 279010002504 catalytic site [active] 279010002505 Cd binding site [ion binding]; other site 279010002506 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 279010002507 dimer interface [polypeptide binding]; other site 279010002508 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010002509 active site 279010002510 metal binding site [ion binding]; metal-binding site 279010002511 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 279010002512 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 279010002513 oligomer interface [polypeptide binding]; other site 279010002514 metal binding site [ion binding]; metal-binding site 279010002515 metal binding site [ion binding]; metal-binding site 279010002516 putative Cl binding site [ion binding]; other site 279010002517 aspartate ring; other site 279010002518 basic sphincter; other site 279010002519 hydrophobic gate; other site 279010002520 periplasmic entrance; other site 279010002521 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 279010002522 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279010002523 minor groove reading motif; other site 279010002524 helix-hairpin-helix signature motif; other site 279010002525 substrate binding pocket [chemical binding]; other site 279010002526 active site 279010002527 TRAM domain; Region: TRAM; pfam01938 279010002528 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 279010002529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002530 S-adenosylmethionine binding site [chemical binding]; other site 279010002531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010002533 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 279010002534 glycosyltransferase, MGT family; Region: MGT; TIGR01426 279010002535 active site 279010002536 TDP-binding site; other site 279010002537 acceptor substrate-binding pocket; other site 279010002538 homodimer interface [polypeptide binding]; other site 279010002539 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 279010002540 benzoate transport; Region: 2A0115; TIGR00895 279010002541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002542 putative substrate translocation pore; other site 279010002543 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 279010002544 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002545 active site turn [active] 279010002546 phosphorylation site [posttranslational modification] 279010002547 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010002548 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010002549 CAT RNA binding domain; Region: CAT_RBD; smart01061 279010002550 PRD domain; Region: PRD; pfam00874 279010002551 PRD domain; Region: PRD; pfam00874 279010002552 Carbonic anhydrase; Region: Pro_CA; pfam00484 279010002553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 279010002554 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 279010002555 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 279010002556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279010002557 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 279010002558 DJ-1 family protein; Region: not_thiJ; TIGR01383 279010002559 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 279010002560 conserved cys residue [active] 279010002561 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 279010002562 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279010002563 tetramer interface [polypeptide binding]; other site 279010002564 TPP-binding site [chemical binding]; other site 279010002565 heterodimer interface [polypeptide binding]; other site 279010002566 phosphorylation loop region [posttranslational modification] 279010002567 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279010002568 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279010002569 alpha subunit interface [polypeptide binding]; other site 279010002570 TPP binding site [chemical binding]; other site 279010002571 heterodimer interface [polypeptide binding]; other site 279010002572 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010002573 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279010002574 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010002575 E3 interaction surface; other site 279010002576 lipoyl attachment site [posttranslational modification]; other site 279010002577 e3 binding domain; Region: E3_binding; pfam02817 279010002578 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279010002579 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 279010002580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010002581 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279010002582 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 279010002583 GAF domain; Region: GAF; pfam01590 279010002584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010002585 Walker A motif; other site 279010002586 ATP binding site [chemical binding]; other site 279010002587 Walker B motif; other site 279010002588 arginine finger; other site 279010002589 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 279010002590 hypothetical protein; Provisional; Region: PRK02237 279010002591 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 279010002592 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 279010002593 NAD binding site [chemical binding]; other site 279010002594 sugar binding site [chemical binding]; other site 279010002595 divalent metal binding site [ion binding]; other site 279010002596 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010002597 dimer interface [polypeptide binding]; other site 279010002598 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010002599 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279010002600 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279010002601 putative active site [active] 279010002602 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 279010002603 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 279010002604 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002605 active site turn [active] 279010002606 phosphorylation site [posttranslational modification] 279010002607 Methyltransferase domain; Region: Methyltransf_23; pfam13489 279010002608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002609 S-adenosylmethionine binding site [chemical binding]; other site 279010002610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 279010002611 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 279010002612 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010002613 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279010002614 Predicted membrane protein [Function unknown]; Region: COG2259 279010002615 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 279010002616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 279010002617 putative metal binding site [ion binding]; other site 279010002618 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010002619 active site 279010002620 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 279010002621 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 279010002622 active site 279010002623 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 279010002624 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 279010002625 inhibitor binding site; inhibition site 279010002626 active site 279010002627 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 279010002628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010002629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010002630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010002631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010002632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 279010002633 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 279010002634 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010002635 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 279010002636 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 279010002637 nudix motif; other site 279010002638 Predicted integral membrane protein [Function unknown]; Region: COG0392 279010002639 Uncharacterized conserved protein [Function unknown]; Region: COG2898 279010002640 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 279010002641 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 279010002642 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 279010002643 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 279010002644 putative FMN binding site [chemical binding]; other site 279010002645 YfhD-like protein; Region: YfhD; pfam14151 279010002646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010002647 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 279010002648 TIGR01777 family protein; Region: yfcH 279010002649 putative NAD(P) binding site [chemical binding]; other site 279010002650 putative active site [active] 279010002651 recombination regulator RecX; Provisional; Region: recX; PRK14135 279010002652 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 279010002653 YpzG-like protein; Region: YpzG; pfam14139 279010002654 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 279010002655 WVELL protein; Region: WVELL; pfam14043 279010002656 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 279010002657 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279010002658 Ligand binding site; other site 279010002659 Putative Catalytic site; other site 279010002660 DXD motif; other site 279010002661 Predicted membrane protein [Function unknown]; Region: COG2246 279010002662 GtrA-like protein; Region: GtrA; pfam04138 279010002663 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 279010002664 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 279010002665 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 279010002666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279010002667 minor groove reading motif; other site 279010002668 helix-hairpin-helix signature motif; other site 279010002669 substrate binding pocket [chemical binding]; other site 279010002670 active site 279010002671 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 279010002672 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 279010002673 DNA binding and oxoG recognition site [nucleotide binding] 279010002674 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 279010002675 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 279010002676 putative NAD(P) binding site [chemical binding]; other site 279010002677 active site 279010002678 YgaB-like protein; Region: YgaB; pfam14182 279010002679 hypothetical protein; Provisional; Region: PRK13662 279010002680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010002681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010002682 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 279010002683 Walker A/P-loop; other site 279010002684 ATP binding site [chemical binding]; other site 279010002685 Q-loop/lid; other site 279010002686 ABC transporter signature motif; other site 279010002687 Walker B; other site 279010002688 D-loop; other site 279010002689 H-loop/switch region; other site 279010002690 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010002691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010002692 Walker A/P-loop; other site 279010002693 ATP binding site [chemical binding]; other site 279010002694 Q-loop/lid; other site 279010002695 ABC transporter signature motif; other site 279010002696 Walker B; other site 279010002697 D-loop; other site 279010002698 H-loop/switch region; other site 279010002699 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 279010002700 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010002701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010002702 Walker A/P-loop; other site 279010002703 ATP binding site [chemical binding]; other site 279010002704 Q-loop/lid; other site 279010002705 ABC transporter signature motif; other site 279010002706 Walker B; other site 279010002707 D-loop; other site 279010002708 H-loop/switch region; other site 279010002709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010002710 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279010002711 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 279010002712 peptide binding site [polypeptide binding]; other site 279010002713 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010002714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002715 dimer interface [polypeptide binding]; other site 279010002716 conserved gate region; other site 279010002717 putative PBP binding loops; other site 279010002718 ABC-ATPase subunit interface; other site 279010002719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279010002720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002721 dimer interface [polypeptide binding]; other site 279010002722 conserved gate region; other site 279010002723 putative PBP binding loops; other site 279010002724 ABC-ATPase subunit interface; other site 279010002725 Predicted membrane protein [Function unknown]; Region: COG4129 279010002726 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 279010002727 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 279010002728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010002729 inhibitor-cofactor binding pocket; inhibition site 279010002730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002731 catalytic residue [active] 279010002732 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 279010002733 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 279010002734 catalytic triad [active] 279010002735 ferric uptake regulator; Provisional; Region: fur; PRK09462 279010002736 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010002737 metal binding site 2 [ion binding]; metal-binding site 279010002738 putative DNA binding helix; other site 279010002739 metal binding site 1 [ion binding]; metal-binding site 279010002740 dimer interface [polypeptide binding]; other site 279010002741 structural Zn2+ binding site [ion binding]; other site 279010002742 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 279010002743 prophage region BLi_Pp1 279010002744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002745 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010002746 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010002747 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010002748 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010002749 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 279010002750 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010002751 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010002752 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010002755 binding surface 279010002756 TPR motif; other site 279010002757 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279010002758 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 279010002759 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 279010002760 active site 279010002761 catalytic residue [active] 279010002762 dimer interface [polypeptide binding]; other site 279010002763 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 279010002764 ThiC-associated domain; Region: ThiC-associated; pfam13667 279010002765 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 279010002766 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 279010002767 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 279010002768 Walker A/P-loop; other site 279010002769 ATP binding site [chemical binding]; other site 279010002770 Q-loop/lid; other site 279010002771 ABC transporter signature motif; other site 279010002772 Walker B; other site 279010002773 D-loop; other site 279010002774 H-loop/switch region; other site 279010002775 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 279010002776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010002777 substrate binding pocket [chemical binding]; other site 279010002778 membrane-bound complex binding site; other site 279010002779 hinge residues; other site 279010002780 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 279010002781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002782 dimer interface [polypeptide binding]; other site 279010002783 conserved gate region; other site 279010002784 putative PBP binding loops; other site 279010002785 ABC-ATPase subunit interface; other site 279010002786 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 279010002787 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 279010002788 active site 279010002789 dimer interface [polypeptide binding]; other site 279010002790 non-prolyl cis peptide bond; other site 279010002791 insertion regions; other site 279010002792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010002793 non-specific DNA binding site [nucleotide binding]; other site 279010002794 salt bridge; other site 279010002795 sequence-specific DNA binding site [nucleotide binding]; other site 279010002796 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279010002797 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010002798 Walker A/P-loop; other site 279010002799 ATP binding site [chemical binding]; other site 279010002800 Q-loop/lid; other site 279010002801 ABC transporter signature motif; other site 279010002802 Walker B; other site 279010002803 D-loop; other site 279010002804 H-loop/switch region; other site 279010002805 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 279010002806 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 279010002807 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 279010002808 B3/4 domain; Region: B3_4; pfam03483 279010002809 epoxyqueuosine reductase; Region: TIGR00276 279010002810 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 279010002811 4Fe-4S binding domain; Region: Fer4; pfam00037 279010002812 HEAT repeats; Region: HEAT_2; pfam13646 279010002813 Putative amidase domain; Region: Amidase_6; pfam12671 279010002814 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 279010002815 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 279010002816 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 279010002817 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 279010002818 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 279010002819 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 279010002820 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 279010002821 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 279010002822 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 279010002823 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010002824 carboxyltransferase (CT) interaction site; other site 279010002825 biotinylation site [posttranslational modification]; other site 279010002826 HlyD family secretion protein; Region: HlyD_3; pfam13437 279010002827 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010002828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002829 putative substrate translocation pore; other site 279010002830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002831 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 279010002832 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010002833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010002834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010002835 Walker A/P-loop; other site 279010002836 ATP binding site [chemical binding]; other site 279010002837 Q-loop/lid; other site 279010002838 ABC transporter signature motif; other site 279010002839 Walker B; other site 279010002840 D-loop; other site 279010002841 H-loop/switch region; other site 279010002842 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010002843 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 279010002844 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010002845 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 279010002846 DNA-binding site [nucleotide binding]; DNA binding site 279010002847 RNA-binding motif; other site 279010002848 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 279010002849 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 279010002850 Walker A/P-loop; other site 279010002851 ATP binding site [chemical binding]; other site 279010002852 Q-loop/lid; other site 279010002853 ABC transporter signature motif; other site 279010002854 Walker B; other site 279010002855 D-loop; other site 279010002856 H-loop/switch region; other site 279010002857 NIL domain; Region: NIL; pfam09383 279010002858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002859 dimer interface [polypeptide binding]; other site 279010002860 conserved gate region; other site 279010002861 ABC-ATPase subunit interface; other site 279010002862 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 279010002863 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 279010002864 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 279010002865 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010002866 FOG: WD40 repeat [General function prediction only]; Region: COG2319 279010002867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010002868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010002869 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 279010002870 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010002871 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 279010002872 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 279010002873 PAS domain; Region: PAS_10; pfam13596 279010002874 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010002875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010002876 putative active site [active] 279010002877 heme pocket [chemical binding]; other site 279010002878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010002879 dimer interface [polypeptide binding]; other site 279010002880 phosphorylation site [posttranslational modification] 279010002881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010002882 ATP binding site [chemical binding]; other site 279010002883 Mg2+ binding site [ion binding]; other site 279010002884 G-X-G motif; other site 279010002885 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 279010002886 generic binding surface II; other site 279010002887 generic binding surface I; other site 279010002888 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 279010002889 generic binding surface II; other site 279010002890 generic binding surface I; other site 279010002891 Staphylococcal nuclease homologues; Region: SNc; smart00318 279010002892 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 279010002893 Catalytic site; other site 279010002894 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279010002895 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 279010002896 putative active site [active] 279010002897 putative metal binding site [ion binding]; other site 279010002898 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010002899 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 279010002900 active site 279010002901 catalytic site [active] 279010002902 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 279010002903 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 279010002904 active site 279010002905 FOG: CBS domain [General function prediction only]; Region: COG0517 279010002906 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 279010002907 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 279010002908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010002909 motif II; other site 279010002910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279010002911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010002912 Coenzyme A binding pocket [chemical binding]; other site 279010002913 Predicted amidohydrolase [General function prediction only]; Region: COG0388 279010002914 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 279010002915 putative active site [active] 279010002916 catalytic triad [active] 279010002917 putative dimer interface [polypeptide binding]; other site 279010002918 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010002919 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002921 ABC transporter; Region: ABC_tran_2; pfam12848 279010002922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010002923 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 279010002924 Predicted permeases [General function prediction only]; Region: COG0679 279010002925 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 279010002926 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 279010002927 NAD(P) binding site [chemical binding]; other site 279010002928 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 279010002929 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 279010002930 amphipathic channel; other site 279010002931 Asn-Pro-Ala signature motifs; other site 279010002932 glycerol kinase; Provisional; Region: glpK; PRK00047 279010002933 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 279010002934 N- and C-terminal domain interface [polypeptide binding]; other site 279010002935 active site 279010002936 MgATP binding site [chemical binding]; other site 279010002937 catalytic site [active] 279010002938 metal binding site [ion binding]; metal-binding site 279010002939 glycerol binding site [chemical binding]; other site 279010002940 homotetramer interface [polypeptide binding]; other site 279010002941 homodimer interface [polypeptide binding]; other site 279010002942 FBP binding site [chemical binding]; other site 279010002943 protein IIAGlc interface [polypeptide binding]; other site 279010002944 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 279010002945 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 279010002946 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 279010002947 active site 279010002948 substrate binding site [chemical binding]; other site 279010002949 metal binding site [ion binding]; metal-binding site 279010002950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010002951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010002952 non-specific DNA binding site [nucleotide binding]; other site 279010002953 salt bridge; other site 279010002954 sequence-specific DNA binding site [nucleotide binding]; other site 279010002955 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 279010002956 GAF domain; Region: GAF; pfam01590 279010002957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 279010002958 Histidine kinase; Region: HisKA_3; pfam07730 279010002959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010002960 ATP binding site [chemical binding]; other site 279010002961 Mg2+ binding site [ion binding]; other site 279010002962 G-X-G motif; other site 279010002963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010002964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010002965 active site 279010002966 phosphorylation site [posttranslational modification] 279010002967 intermolecular recognition site; other site 279010002968 dimerization interface [polypeptide binding]; other site 279010002969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010002970 DNA binding residues [nucleotide binding] 279010002971 dimerization interface [polypeptide binding]; other site 279010002972 Predicted flavoprotein [General function prediction only]; Region: COG0431 279010002973 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010002974 YhdB-like protein; Region: YhdB; pfam14148 279010002975 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 279010002976 Transcriptional regulator; Region: Rrf2; cl17282 279010002977 Rrf2 family protein; Region: rrf2_super; TIGR00738 279010002978 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 279010002979 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 279010002980 heme-binding site [chemical binding]; other site 279010002981 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 279010002982 FAD binding pocket [chemical binding]; other site 279010002983 FAD binding motif [chemical binding]; other site 279010002984 phosphate binding motif [ion binding]; other site 279010002985 beta-alpha-beta structure motif; other site 279010002986 NAD binding pocket [chemical binding]; other site 279010002987 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 279010002988 SpoVR like protein; Region: SpoVR; pfam04293 279010002989 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010002990 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010002991 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010002992 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010002993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010002994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010002995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010002996 dimerization interface [polypeptide binding]; other site 279010002997 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 279010002998 dimer interface [polypeptide binding]; other site 279010002999 Citrate synthase; Region: Citrate_synt; pfam00285 279010003000 active site 279010003001 citrylCoA binding site [chemical binding]; other site 279010003002 oxalacetate/citrate binding site [chemical binding]; other site 279010003003 coenzyme A binding site [chemical binding]; other site 279010003004 catalytic triad [active] 279010003005 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 279010003006 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 279010003007 short chain dehydrogenase; Provisional; Region: PRK06701 279010003008 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279010003009 NAD binding site [chemical binding]; other site 279010003010 metal binding site [ion binding]; metal-binding site 279010003011 active site 279010003012 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 279010003013 Na2 binding site [ion binding]; other site 279010003014 putative substrate binding site 1 [chemical binding]; other site 279010003015 Na binding site 1 [ion binding]; other site 279010003016 putative substrate binding site 2 [chemical binding]; other site 279010003017 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 279010003018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010003019 catalytic residue [active] 279010003020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010003021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 279010003023 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010003024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010003025 DNA-binding site [nucleotide binding]; DNA binding site 279010003026 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010003027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003028 homodimer interface [polypeptide binding]; other site 279010003029 catalytic residue [active] 279010003030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010003031 Coenzyme A binding pocket [chemical binding]; other site 279010003032 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 279010003033 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 279010003034 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 279010003035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010003036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010003037 DNA binding residues [nucleotide binding] 279010003038 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 279010003039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 279010003040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 279010003041 putative acyl-acceptor binding pocket; other site 279010003042 Protein of unknown function (DUF805); Region: DUF805; pfam05656 279010003043 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 279010003044 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 279010003045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010003046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010003047 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010003048 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010003049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010003050 Transporter associated domain; Region: CorC_HlyC; smart01091 279010003051 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 279010003052 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010003053 DNA binding residues [nucleotide binding] 279010003054 putative dimer interface [polypeptide binding]; other site 279010003055 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010003056 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010003057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010003058 Transporter associated domain; Region: CorC_HlyC; smart01091 279010003059 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010003060 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010003061 active site 279010003062 metal binding site [ion binding]; metal-binding site 279010003063 camphor resistance protein CrcB; Provisional; Region: PRK14213 279010003064 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 279010003065 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010003066 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279010003067 active site 279010003068 catalytic site [active] 279010003069 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 279010003070 Mechanosensitive ion channel; Region: MS_channel; pfam00924 279010003071 NAD-dependent deacetylase; Provisional; Region: PRK00481 279010003072 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 279010003073 NAD+ binding site [chemical binding]; other site 279010003074 substrate binding site [chemical binding]; other site 279010003075 Zn binding site [ion binding]; other site 279010003076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279010003077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010003078 Coenzyme A binding pocket [chemical binding]; other site 279010003079 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 279010003080 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279010003081 NodB motif; other site 279010003082 active site 279010003083 catalytic site [active] 279010003084 Zn binding site [ion binding]; other site 279010003085 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 279010003086 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 279010003087 homodimer interface [polypeptide binding]; other site 279010003088 substrate-cofactor binding pocket; other site 279010003089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003090 catalytic residue [active] 279010003091 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 279010003092 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 279010003093 active site 279010003094 catalytic residues [active] 279010003095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003096 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 279010003097 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 279010003098 YcaO-like family; Region: YcaO; pfam02624 279010003099 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 279010003100 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 279010003101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 279010003102 Ligand Binding Site [chemical binding]; other site 279010003103 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 279010003104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010003105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010003106 Walker A/P-loop; other site 279010003107 ATP binding site [chemical binding]; other site 279010003108 Q-loop/lid; other site 279010003109 ABC transporter signature motif; other site 279010003110 Walker B; other site 279010003111 D-loop; other site 279010003112 H-loop/switch region; other site 279010003113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010003114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010003115 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 279010003116 Walker A/P-loop; other site 279010003117 ATP binding site [chemical binding]; other site 279010003118 Q-loop/lid; other site 279010003119 ABC transporter signature motif; other site 279010003120 Walker B; other site 279010003121 D-loop; other site 279010003122 H-loop/switch region; other site 279010003123 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 279010003124 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010003125 NAD binding site [chemical binding]; other site 279010003126 substrate binding site [chemical binding]; other site 279010003127 putative active site [active] 279010003128 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010003129 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 279010003130 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 279010003131 Walker A/P-loop; other site 279010003132 ATP binding site [chemical binding]; other site 279010003133 Q-loop/lid; other site 279010003134 ABC transporter signature motif; other site 279010003135 Walker B; other site 279010003136 D-loop; other site 279010003137 H-loop/switch region; other site 279010003138 TOBE domain; Region: TOBE; pfam03459 279010003139 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 279010003140 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 279010003141 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 279010003142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 279010003143 hypothetical protein; Provisional; Region: PRK13676 279010003144 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010003145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010003146 active site 279010003147 motif I; other site 279010003148 motif II; other site 279010003149 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 279010003150 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 279010003151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010003152 FeS/SAM binding site; other site 279010003153 enoyl-CoA hydratase; Provisional; Region: PRK07659 279010003154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010003155 substrate binding site [chemical binding]; other site 279010003156 oxyanion hole (OAH) forming residues; other site 279010003157 trimer interface [polypeptide binding]; other site 279010003158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010003159 TPR motif; other site 279010003160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010003161 binding surface 279010003162 YhzD-like protein; Region: YhzD; pfam14120 279010003163 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 279010003164 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 279010003165 Walker A/P-loop; other site 279010003166 ATP binding site [chemical binding]; other site 279010003167 Q-loop/lid; other site 279010003168 ABC transporter signature motif; other site 279010003169 Walker B; other site 279010003170 D-loop; other site 279010003171 H-loop/switch region; other site 279010003172 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010003173 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 279010003174 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 279010003175 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 279010003176 active site 279010003177 metal binding site [ion binding]; metal-binding site 279010003178 DNA binding site [nucleotide binding] 279010003179 Uncharacterized conserved protein [Function unknown]; Region: COG4717 279010003180 P-loop containing region of AAA domain; Region: AAA_29; cl17516 279010003181 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 279010003182 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 279010003183 generic binding surface II; other site 279010003184 generic binding surface I; other site 279010003185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010003186 Zn2+ binding site [ion binding]; other site 279010003187 Mg2+ binding site [ion binding]; other site 279010003188 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 279010003189 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 279010003190 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 279010003191 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 279010003192 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 279010003193 transcriptional regulator Hpr; Provisional; Region: PRK13777 279010003194 MarR family; Region: MarR; pfam01047 279010003195 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 279010003196 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 279010003197 homodimer interface [polypeptide binding]; other site 279010003198 substrate-cofactor binding pocket; other site 279010003199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003200 catalytic residue [active] 279010003201 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 279010003202 HIT family signature motif; other site 279010003203 catalytic residue [active] 279010003204 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279010003205 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010003206 Walker A/P-loop; other site 279010003207 ATP binding site [chemical binding]; other site 279010003208 Q-loop/lid; other site 279010003209 ABC transporter signature motif; other site 279010003210 Walker B; other site 279010003211 D-loop; other site 279010003212 H-loop/switch region; other site 279010003213 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 279010003214 EcsC protein family; Region: EcsC; pfam12787 279010003215 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010003216 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279010003217 metal binding site [ion binding]; metal-binding site 279010003218 dimer interface [polypeptide binding]; other site 279010003219 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 279010003220 Transglycosylase; Region: Transgly; pfam00912 279010003221 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010003222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010003223 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 279010003224 substrate binding site [chemical binding]; other site 279010003225 active site 279010003226 ferrochelatase; Provisional; Region: PRK12435 279010003227 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 279010003228 C-terminal domain interface [polypeptide binding]; other site 279010003229 active site 279010003230 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 279010003231 active site 279010003232 N-terminal domain interface [polypeptide binding]; other site 279010003233 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 279010003234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279010003235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010003236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010003237 Predicted membrane protein [Function unknown]; Region: COG1511 279010003238 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279010003239 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 279010003240 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 279010003241 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 279010003242 dimer interface [polypeptide binding]; other site 279010003243 active site 279010003244 CoA binding pocket [chemical binding]; other site 279010003245 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279010003246 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 279010003247 putative oligomer interface [polypeptide binding]; other site 279010003248 putative active site [active] 279010003249 metal binding site [ion binding]; metal-binding site 279010003250 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010003251 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010003252 YhfH-like protein; Region: YhfH; pfam14149 279010003253 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 279010003254 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279010003255 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 279010003256 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 279010003257 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 279010003258 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 279010003259 acyl-activating enzyme (AAE) consensus motif; other site 279010003260 putative AMP binding site [chemical binding]; other site 279010003261 putative active site [active] 279010003262 putative CoA binding site [chemical binding]; other site 279010003263 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010003264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003265 non-specific DNA binding site [nucleotide binding]; other site 279010003266 salt bridge; other site 279010003267 sequence-specific DNA binding site [nucleotide binding]; other site 279010003268 Cupin domain; Region: Cupin_2; pfam07883 279010003269 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 279010003270 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 279010003271 Peptidase family M48; Region: Peptidase_M48; pfam01435 279010003272 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010003273 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 279010003274 active site 279010003275 catalytic residues [active] 279010003276 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010003277 EamA-like transporter family; Region: EamA; pfam00892 279010003278 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 279010003279 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279010003280 siderophore binding site; other site 279010003281 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 279010003282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010003283 ABC-ATPase subunit interface; other site 279010003284 dimer interface [polypeptide binding]; other site 279010003285 putative PBP binding regions; other site 279010003286 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010003287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010003288 ABC-ATPase subunit interface; other site 279010003289 dimer interface [polypeptide binding]; other site 279010003290 putative PBP binding regions; other site 279010003291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279010003292 catalytic core [active] 279010003293 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 279010003294 heme-binding site [chemical binding]; other site 279010003295 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010003296 dimer interface [polypeptide binding]; other site 279010003297 putative CheW interface [polypeptide binding]; other site 279010003298 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 279010003299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279010003300 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 279010003301 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 279010003302 [2Fe-2S] cluster binding site [ion binding]; other site 279010003303 short chain dehydrogenase; Provisional; Region: PRK06701 279010003304 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279010003305 NAD binding site [chemical binding]; other site 279010003306 metal binding site [ion binding]; metal-binding site 279010003307 active site 279010003308 A short protein domain of unknown function; Region: IDEAL; smart00914 279010003309 ComK protein; Region: ComK; pfam06338 279010003310 Uncharacterized conserved protein [Function unknown]; Region: COG0398 279010003311 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279010003312 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279010003313 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279010003314 Catalytic site [active] 279010003315 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010003316 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 279010003317 active site 279010003318 catalytic residues [active] 279010003319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010003321 putative substrate translocation pore; other site 279010003322 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 279010003323 DRTGG domain; Region: DRTGG; pfam07085 279010003324 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010003325 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 279010003326 allantoinase; Provisional; Region: PRK08044 279010003327 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 279010003328 active site 279010003329 allantoate amidohydrolase; Region: AllC; TIGR03176 279010003330 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 279010003331 active site 279010003332 metal binding site [ion binding]; metal-binding site 279010003333 dimer interface [polypeptide binding]; other site 279010003334 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 279010003335 Cupin domain; Region: Cupin_2; pfam07883 279010003336 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 279010003337 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 279010003338 membrane protein FdrA; Validated; Region: PRK06091 279010003339 CoA binding domain; Region: CoA_binding; pfam02629 279010003340 CoA-ligase; Region: Ligase_CoA; pfam00549 279010003341 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 279010003342 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 279010003343 carbamate kinase; Reviewed; Region: PRK12686 279010003344 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 279010003345 putative substrate binding site [chemical binding]; other site 279010003346 nucleotide binding site [chemical binding]; other site 279010003347 nucleotide binding site [chemical binding]; other site 279010003348 homodimer interface [polypeptide binding]; other site 279010003349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003350 D-galactonate transporter; Region: 2A0114; TIGR00893 279010003351 putative substrate translocation pore; other site 279010003352 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 279010003353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010003354 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010003355 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 279010003356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010003357 DNA binding site [nucleotide binding] 279010003358 domain linker motif; other site 279010003359 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 279010003360 putative dimerization interface [polypeptide binding]; other site 279010003361 putative ligand binding site [chemical binding]; other site 279010003362 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010003363 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010003364 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010003365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003366 dimer interface [polypeptide binding]; other site 279010003367 conserved gate region; other site 279010003368 putative PBP binding loops; other site 279010003369 ABC-ATPase subunit interface; other site 279010003370 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010003371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003372 dimer interface [polypeptide binding]; other site 279010003373 conserved gate region; other site 279010003374 putative PBP binding loops; other site 279010003375 ABC-ATPase subunit interface; other site 279010003376 alpha-galactosidase; Provisional; Region: PRK15076 279010003377 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 279010003378 NAD binding site [chemical binding]; other site 279010003379 sugar binding site [chemical binding]; other site 279010003380 divalent metal binding site [ion binding]; other site 279010003381 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010003382 dimer interface [polypeptide binding]; other site 279010003383 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 279010003384 Putative ammonia monooxygenase; Region: AmoA; pfam05145 279010003385 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 279010003386 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 279010003387 CotJB protein; Region: CotJB; pfam12652 279010003388 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 279010003389 dimanganese center [ion binding]; other site 279010003390 AMP-binding domain protein; Validated; Region: PRK08315 279010003391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 279010003392 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 279010003393 acyl-activating enzyme (AAE) consensus motif; other site 279010003394 putative AMP binding site [chemical binding]; other site 279010003395 putative active site [active] 279010003396 putative CoA binding site [chemical binding]; other site 279010003397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 279010003398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010003399 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 279010003400 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010003401 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 279010003402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010003403 dimerization interface [polypeptide binding]; other site 279010003404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010003405 dimer interface [polypeptide binding]; other site 279010003406 phosphorylation site [posttranslational modification] 279010003407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010003408 ATP binding site [chemical binding]; other site 279010003409 Mg2+ binding site [ion binding]; other site 279010003410 G-X-G motif; other site 279010003411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010003412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010003413 active site 279010003414 phosphorylation site [posttranslational modification] 279010003415 intermolecular recognition site; other site 279010003416 dimerization interface [polypeptide binding]; other site 279010003417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010003418 DNA binding site [nucleotide binding] 279010003419 Uncharacterized conserved protein [Function unknown]; Region: COG1633 279010003420 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 279010003421 dinuclear metal binding motif [ion binding]; other site 279010003422 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 279010003423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 279010003424 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 279010003425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003426 dimer interface [polypeptide binding]; other site 279010003427 conserved gate region; other site 279010003428 putative PBP binding loops; other site 279010003429 ABC-ATPase subunit interface; other site 279010003430 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 279010003431 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 279010003432 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 279010003433 Part of AAA domain; Region: AAA_19; pfam13245 279010003434 Family description; Region: UvrD_C_2; pfam13538 279010003435 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 279010003436 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 279010003437 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010003438 active site 279010003439 metal binding site [ion binding]; metal-binding site 279010003440 DNA binding site [nucleotide binding] 279010003441 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 279010003442 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 279010003443 AAA domain; Region: AAA_23; pfam13476 279010003444 Walker A/P-loop; other site 279010003445 ATP binding site [chemical binding]; other site 279010003446 Q-loop/lid; other site 279010003447 ABC transporter signature motif; other site 279010003448 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 279010003449 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 279010003450 ABC transporter signature motif; other site 279010003451 Walker B; other site 279010003452 D-loop; other site 279010003453 H-loop/switch region; other site 279010003454 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010003455 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 279010003456 Spore germination protein GerPC; Region: GerPC; pfam10737 279010003457 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 279010003458 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010003459 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 279010003460 CotH protein; Region: CotH; pfam08757 279010003461 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 279010003462 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 279010003463 GTPase RsgA; Reviewed; Region: PRK01889 279010003464 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279010003465 RNA binding site [nucleotide binding]; other site 279010003466 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 279010003467 GTPase/Zn-binding domain interface [polypeptide binding]; other site 279010003468 GTP/Mg2+ binding site [chemical binding]; other site 279010003469 G4 box; other site 279010003470 G5 box; other site 279010003471 G1 box; other site 279010003472 Switch I region; other site 279010003473 G2 box; other site 279010003474 G3 box; other site 279010003475 Switch II region; other site 279010003476 hypothetical protein; Provisional; Region: PRK13673 279010003477 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 279010003478 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 279010003479 active site 279010003480 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 279010003481 dimer interface [polypeptide binding]; other site 279010003482 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 279010003483 Ligand Binding Site [chemical binding]; other site 279010003484 Molecular Tunnel; other site 279010003485 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 279010003486 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 279010003487 Nitrogen regulatory protein P-II; Region: P-II; smart00938 279010003488 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 279010003489 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 279010003490 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 279010003491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010003493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003494 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010003495 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010003496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010003497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010003498 DNA binding site [nucleotide binding] 279010003499 domain linker motif; other site 279010003500 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279010003501 dimerization interface [polypeptide binding]; other site 279010003502 ligand binding site [chemical binding]; other site 279010003503 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010003504 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010003505 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 279010003506 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010003507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010003508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003509 homodimer interface [polypeptide binding]; other site 279010003510 catalytic residue [active] 279010003511 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 279010003512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010003513 inhibitor-cofactor binding pocket; inhibition site 279010003514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003515 catalytic residue [active] 279010003516 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 279010003517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003518 catalytic residue [active] 279010003519 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 279010003520 IucA / IucC family; Region: IucA_IucC; pfam04183 279010003521 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279010003522 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 279010003523 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 279010003524 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 279010003525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010003526 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 279010003527 IucA / IucC family; Region: IucA_IucC; pfam04183 279010003528 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279010003529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010003530 Coenzyme A binding pocket [chemical binding]; other site 279010003531 short chain dehydrogenase; Provisional; Region: PRK08303 279010003532 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs; Region: DHRS1-like_SDR_c; cd09763 279010003533 NAD(P) binding site [chemical binding]; other site 279010003534 putative dimer interface [polypeptide binding]; other site 279010003535 active site 279010003536 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010003537 HTH domain; Region: HTH_11; pfam08279 279010003538 WYL domain; Region: WYL; pfam13280 279010003539 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 279010003540 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 279010003541 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 279010003542 substrate binding pocket [chemical binding]; other site 279010003543 dimer interface [polypeptide binding]; other site 279010003544 inhibitor binding site; inhibition site 279010003545 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 279010003546 B12 binding site [chemical binding]; other site 279010003547 cobalt ligand [ion binding]; other site 279010003548 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 279010003549 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 279010003550 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 279010003551 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 279010003552 FAD binding site [chemical binding]; other site 279010003553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 279010003554 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 279010003555 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 279010003556 S1 domain; Region: S1_2; pfam13509 279010003557 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 279010003558 RNA binding site [nucleotide binding]; other site 279010003559 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010003560 EDD domain protein, DegV family; Region: DegV; TIGR00762 279010003561 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 279010003562 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010003563 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010003564 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010003565 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010003566 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 279010003567 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 279010003568 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 279010003569 active site 279010003570 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 279010003571 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010003572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010003573 motif II; other site 279010003574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010003575 esterase; Provisional; Region: PRK10566 279010003576 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 279010003577 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 279010003578 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 279010003579 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 279010003580 heterotetramer interface [polypeptide binding]; other site 279010003581 active site pocket [active] 279010003582 cleavage site 279010003583 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 279010003584 nucleotide binding site [chemical binding]; other site 279010003585 N-acetyl-L-glutamate binding site [chemical binding]; other site 279010003586 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 279010003587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010003588 inhibitor-cofactor binding pocket; inhibition site 279010003589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003590 catalytic residue [active] 279010003591 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 279010003592 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 279010003593 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 279010003594 catalytic site [active] 279010003595 subunit interface [polypeptide binding]; other site 279010003596 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 279010003597 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010003598 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279010003599 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 279010003600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010003601 ATP-grasp domain; Region: ATP-grasp_4; cl17255 279010003602 ornithine carbamoyltransferase; Provisional; Region: PRK00779 279010003603 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279010003604 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 279010003605 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 279010003606 YjzC-like protein; Region: YjzC; pfam14168 279010003607 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 279010003608 LytB protein; Region: LYTB; cl00507 279010003609 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 279010003610 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 279010003611 putative ligand binding site [chemical binding]; other site 279010003612 ComZ; Region: ComZ; pfam10815 279010003613 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 279010003614 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 279010003615 dimer interface [polypeptide binding]; other site 279010003616 active site 279010003617 CoA binding pocket [chemical binding]; other site 279010003618 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 279010003619 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 279010003620 dimer interface [polypeptide binding]; other site 279010003621 active site 279010003622 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 279010003623 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010003625 Walker A/P-loop; other site 279010003626 ATP binding site [chemical binding]; other site 279010003627 Q-loop/lid; other site 279010003628 ABC transporter signature motif; other site 279010003629 Walker B; other site 279010003630 D-loop; other site 279010003631 H-loop/switch region; other site 279010003632 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 279010003633 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 279010003634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010003635 Walker A/P-loop; other site 279010003636 ATP binding site [chemical binding]; other site 279010003637 Q-loop/lid; other site 279010003638 ABC transporter signature motif; other site 279010003639 Walker B; other site 279010003640 D-loop; other site 279010003641 H-loop/switch region; other site 279010003642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003643 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279010003644 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 279010003645 peptide binding site [polypeptide binding]; other site 279010003646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010003647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003648 dimer interface [polypeptide binding]; other site 279010003649 conserved gate region; other site 279010003650 putative PBP binding loops; other site 279010003651 ABC-ATPase subunit interface; other site 279010003652 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 279010003653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003654 dimer interface [polypeptide binding]; other site 279010003655 conserved gate region; other site 279010003656 putative PBP binding loops; other site 279010003657 ABC-ATPase subunit interface; other site 279010003658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003659 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010003660 putative substrate translocation pore; other site 279010003661 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 279010003662 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 279010003663 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 279010003664 active site 279010003665 HIGH motif; other site 279010003666 dimer interface [polypeptide binding]; other site 279010003667 KMSKS motif; other site 279010003668 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 279010003669 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 279010003670 peptide binding site [polypeptide binding]; other site 279010003671 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010003672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003673 dimer interface [polypeptide binding]; other site 279010003674 conserved gate region; other site 279010003675 putative PBP binding loops; other site 279010003676 ABC-ATPase subunit interface; other site 279010003677 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279010003678 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 279010003679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003680 dimer interface [polypeptide binding]; other site 279010003681 conserved gate region; other site 279010003682 putative PBP binding loops; other site 279010003683 ABC-ATPase subunit interface; other site 279010003684 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010003686 Walker A/P-loop; other site 279010003687 ATP binding site [chemical binding]; other site 279010003688 Q-loop/lid; other site 279010003689 ABC transporter signature motif; other site 279010003690 Walker B; other site 279010003691 D-loop; other site 279010003692 H-loop/switch region; other site 279010003693 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003694 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010003696 Walker A/P-loop; other site 279010003697 ATP binding site [chemical binding]; other site 279010003698 Q-loop/lid; other site 279010003699 ABC transporter signature motif; other site 279010003700 Walker B; other site 279010003701 D-loop; other site 279010003702 H-loop/switch region; other site 279010003703 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 279010003704 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 279010003705 ArsC family; Region: ArsC; pfam03960 279010003706 putative catalytic residues [active] 279010003707 thiol/disulfide switch; other site 279010003708 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 279010003709 adaptor protein; Provisional; Region: PRK02315 279010003710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 279010003711 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 279010003712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 279010003713 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 279010003714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010003715 active site 279010003716 phosphorylation site [posttranslational modification] 279010003717 intermolecular recognition site; other site 279010003718 dimerization interface [polypeptide binding]; other site 279010003719 Transcriptional regulator; Region: CitT; pfam12431 279010003720 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 279010003721 PAS domain; Region: PAS; smart00091 279010003722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010003723 ATP binding site [chemical binding]; other site 279010003724 Mg2+ binding site [ion binding]; other site 279010003725 G-X-G motif; other site 279010003726 Competence protein CoiA-like family; Region: CoiA; cl11541 279010003727 oligoendopeptidase F; Region: pepF; TIGR00181 279010003728 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 279010003729 active site 279010003730 Zn binding site [ion binding]; other site 279010003731 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 279010003732 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 279010003733 catalytic residues [active] 279010003734 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 279010003735 apolar tunnel; other site 279010003736 heme binding site [chemical binding]; other site 279010003737 dimerization interface [polypeptide binding]; other site 279010003738 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 279010003739 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279010003740 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010003741 catalytic residue [active] 279010003742 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 279010003743 putative active site [active] 279010003744 putative metal binding residues [ion binding]; other site 279010003745 signature motif; other site 279010003746 putative triphosphate binding site [ion binding]; other site 279010003747 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279010003748 synthetase active site [active] 279010003749 NTP binding site [chemical binding]; other site 279010003750 metal binding site [ion binding]; metal-binding site 279010003751 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 279010003752 ATP-NAD kinase; Region: NAD_kinase; pfam01513 279010003753 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 279010003754 Ubiquitin-like proteins; Region: UBQ; cl00155 279010003755 hydrophobic patch; other site 279010003756 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 279010003757 active site 279010003758 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 279010003759 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 279010003760 active site 279010003761 metal binding site [ion binding]; metal-binding site 279010003762 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 279010003763 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 279010003764 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279010003765 TrkA-N domain; Region: TrkA_N; pfam02254 279010003766 TrkA-C domain; Region: TrkA_C; pfam02080 279010003767 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 279010003768 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 279010003769 thiamine phosphate binding site [chemical binding]; other site 279010003770 active site 279010003771 pyrophosphate binding site [ion binding]; other site 279010003772 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 279010003773 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 279010003774 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 279010003775 thiS-thiF/thiG interaction site; other site 279010003776 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 279010003777 ThiS interaction site; other site 279010003778 putative active site [active] 279010003779 tetramer interface [polypeptide binding]; other site 279010003780 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 279010003781 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 279010003782 ATP binding site [chemical binding]; other site 279010003783 substrate interface [chemical binding]; other site 279010003784 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 279010003785 dimer interface [polypeptide binding]; other site 279010003786 substrate binding site [chemical binding]; other site 279010003787 ATP binding site [chemical binding]; other site 279010003788 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 279010003789 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 279010003790 NAD binding site [chemical binding]; other site 279010003791 homotetramer interface [polypeptide binding]; other site 279010003792 homodimer interface [polypeptide binding]; other site 279010003793 substrate binding site [chemical binding]; other site 279010003794 active site 279010003795 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 279010003796 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 279010003797 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 279010003798 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 279010003799 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 279010003800 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 279010003801 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 279010003802 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 279010003803 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 279010003804 Part of AAA domain; Region: AAA_19; pfam13245 279010003805 Family description; Region: UvrD_C_2; pfam13538 279010003806 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 279010003807 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279010003808 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010003809 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 279010003810 NAD binding site [chemical binding]; other site 279010003811 homodimer interface [polypeptide binding]; other site 279010003812 active site 279010003813 substrate binding site [chemical binding]; other site 279010003814 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 279010003815 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 279010003816 active site 279010003817 tetramer interface; other site 279010003818 Predicted membrane protein [Function unknown]; Region: COG2246 279010003819 GtrA-like protein; Region: GtrA; pfam04138 279010003820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010003821 Coenzyme A binding pocket [chemical binding]; other site 279010003822 hypothetical protein; Provisional; Region: PRK13679 279010003823 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279010003824 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 279010003825 Putative esterase; Region: Esterase; pfam00756 279010003826 DinB superfamily; Region: DinB_2; pfam12867 279010003827 DinB family; Region: DinB; cl17821 279010003828 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010003829 HTH domain; Region: HTH_11; pfam08279 279010003830 WYL domain; Region: WYL; pfam13280 279010003831 cystathionine gamma-synthase; Reviewed; Region: PRK08247 279010003832 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279010003833 homodimer interface [polypeptide binding]; other site 279010003834 substrate-cofactor binding pocket; other site 279010003835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003836 catalytic residue [active] 279010003837 cystathionine beta-lyase; Provisional; Region: PRK08064 279010003838 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279010003839 homodimer interface [polypeptide binding]; other site 279010003840 substrate-cofactor binding pocket; other site 279010003841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003842 catalytic residue [active] 279010003843 Predicted integral membrane protein [Function unknown]; Region: COG5505 279010003844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010003845 MarR family; Region: MarR_2; pfam12802 279010003846 Beta-lactamase; Region: Beta-lactamase; pfam00144 279010003847 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279010003848 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 279010003849 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 279010003850 substrate binding site [chemical binding]; other site 279010003851 active site 279010003852 maltose O-acetyltransferase; Provisional; Region: PRK10092 279010003853 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 279010003854 active site 279010003855 substrate binding site [chemical binding]; other site 279010003856 trimer interface [polypeptide binding]; other site 279010003857 CoA binding site [chemical binding]; other site 279010003858 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 279010003859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010003860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010003861 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 279010003862 putative dimerization interface [polypeptide binding]; other site 279010003863 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 279010003864 Flavodoxin; Region: Flavodoxin_1; pfam00258 279010003865 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 279010003866 FAD binding pocket [chemical binding]; other site 279010003867 FAD binding motif [chemical binding]; other site 279010003868 catalytic residues [active] 279010003869 NAD binding pocket [chemical binding]; other site 279010003870 phosphate binding motif [ion binding]; other site 279010003871 beta-alpha-beta structure motif; other site 279010003872 sulfite reductase subunit beta; Provisional; Region: PRK13504 279010003873 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010003874 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010003875 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 279010003876 EamA-like transporter family; Region: EamA; pfam00892 279010003877 EamA-like transporter family; Region: EamA; pfam00892 279010003878 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 279010003879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010003880 putative metal binding site [ion binding]; other site 279010003881 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010003882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010003883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 279010003884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010003886 putative substrate translocation pore; other site 279010003887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010003889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010003890 Regulatory protein YrvL; Region: YrvL; pfam14184 279010003891 Protein of unknown function, DUF600; Region: DUF600; pfam04634 279010003892 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010003893 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 279010003894 Protein of unknown function (DUF867); Region: DUF867; pfam05908 279010003895 Domain of unknown function (DUF955); Region: DUF955; pfam06114 279010003896 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010003897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003898 non-specific DNA binding site [nucleotide binding]; other site 279010003899 salt bridge; other site 279010003900 sequence-specific DNA binding site [nucleotide binding]; other site 279010003901 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010003902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003903 non-specific DNA binding site [nucleotide binding]; other site 279010003904 salt bridge; other site 279010003905 sequence-specific DNA binding site [nucleotide binding]; other site 279010003906 Transcriptional regulator; Region: Rrf2; cl17282 279010003907 hypothetical protein; Provisional; Region: PRK06921 279010003908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010003909 Walker A motif; other site 279010003910 ATP binding site [chemical binding]; other site 279010003911 Walker B motif; other site 279010003912 positive control sigma-like factor; Validated; Region: PRK06930 279010003913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010003914 DNA binding residues [nucleotide binding] 279010003915 Phage terminase small subunit; Region: Phage_terminase; pfam10668 279010003916 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 279010003917 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 279010003918 Terminase-like family; Region: Terminase_6; pfam03237 279010003919 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 279010003920 Phage capsid family; Region: Phage_capsid; pfam05065 279010003921 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 279010003922 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 279010003923 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 279010003924 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 279010003925 Phage XkdN-like protein; Region: XkdN; pfam08890 279010003926 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 279010003927 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279010003928 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010003929 catalytic residue [active] 279010003930 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 279010003931 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010003932 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 279010003933 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 279010003934 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 279010003935 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 279010003936 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 279010003937 CRISPR-associated protein Cas4/Csa1, subtype I-A/APERN; Region: cas_AF1879; TIGR01896 279010003938 Haemolysin XhlA; Region: XhlA; pfam10779 279010003939 holin, SPP1 family; Region: holin_SPP1; TIGR01592 279010003940 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279010003941 amidase catalytic site [active] 279010003942 Zn binding residues [ion binding]; other site 279010003943 substrate binding site [chemical binding]; other site 279010003944 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 279010003945 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010003946 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010003947 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010003948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010003949 DNA-binding site [nucleotide binding]; DNA binding site 279010003950 FCD domain; Region: FCD; pfam07729 279010003951 putative oxidoreductase; Provisional; Region: PRK10083 279010003952 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 279010003953 putative NAD(P) binding site [chemical binding]; other site 279010003954 catalytic Zn binding site [ion binding]; other site 279010003955 structural Zn binding site [ion binding]; other site 279010003956 mannonate dehydratase; Provisional; Region: PRK03906 279010003957 mannonate dehydratase; Region: uxuA; TIGR00695 279010003958 D-mannonate oxidoreductase; Provisional; Region: PRK08277 279010003959 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 279010003960 putative NAD(P) binding site [chemical binding]; other site 279010003961 active site 279010003962 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 279010003963 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 279010003964 putative NAD(P) binding site [chemical binding]; other site 279010003965 catalytic Zn binding site [ion binding]; other site 279010003966 structural Zn binding site [ion binding]; other site 279010003967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003968 D-galactonate transporter; Region: 2A0114; TIGR00893 279010003969 putative substrate translocation pore; other site 279010003970 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 279010003971 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 279010003972 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 279010003973 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 279010003974 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 279010003975 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 279010003976 Predicted integral membrane protein [Function unknown]; Region: COG5578 279010003977 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 279010003978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010003979 dimerization interface [polypeptide binding]; other site 279010003980 Histidine kinase; Region: His_kinase; pfam06580 279010003981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010003982 ATP binding site [chemical binding]; other site 279010003983 Mg2+ binding site [ion binding]; other site 279010003984 G-X-G motif; other site 279010003985 Response regulator receiver domain; Region: Response_reg; pfam00072 279010003986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010003987 active site 279010003988 phosphorylation site [posttranslational modification] 279010003989 intermolecular recognition site; other site 279010003990 dimerization interface [polypeptide binding]; other site 279010003991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010003992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003993 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010003994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010003995 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010003996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003997 dimer interface [polypeptide binding]; other site 279010003998 conserved gate region; other site 279010003999 putative PBP binding loops; other site 279010004000 ABC-ATPase subunit interface; other site 279010004001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010004002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010004003 dimer interface [polypeptide binding]; other site 279010004004 conserved gate region; other site 279010004005 putative PBP binding loops; other site 279010004006 ABC-ATPase subunit interface; other site 279010004007 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 279010004008 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 279010004009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010004010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010004011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010004012 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010004013 active site 279010004014 catalytic triad [active] 279010004015 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 279010004016 Predicted integral membrane protein [Function unknown]; Region: COG5578 279010004017 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 279010004018 metal binding site [ion binding]; metal-binding site 279010004019 active site 279010004020 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010004021 active site 279010004022 catalytic triad [active] 279010004023 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 279010004024 metal binding site [ion binding]; metal-binding site 279010004025 active site 279010004026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010004027 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010004028 active site 279010004029 catalytic tetrad [active] 279010004030 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010004031 active site 279010004032 catalytic triad [active] 279010004033 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 279010004034 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 279010004035 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 279010004036 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 279010004037 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010004038 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010004039 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010004040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010004041 dimer interface [polypeptide binding]; other site 279010004042 conserved gate region; other site 279010004043 ABC-ATPase subunit interface; other site 279010004044 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010004045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010004046 dimer interface [polypeptide binding]; other site 279010004047 conserved gate region; other site 279010004048 putative PBP binding loops; other site 279010004049 ABC-ATPase subunit interface; other site 279010004050 amino acid transporter; Region: 2A0306; TIGR00909 279010004051 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 279010004052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010004053 Zn binding site [ion binding]; other site 279010004054 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 279010004055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010004056 Zn binding site [ion binding]; other site 279010004057 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 279010004058 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279010004059 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010004060 protein binding site [polypeptide binding]; other site 279010004061 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 279010004062 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 279010004063 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 279010004064 SxDxEG motif; other site 279010004065 active site 279010004066 metal binding site [ion binding]; metal-binding site 279010004067 homopentamer interface [polypeptide binding]; other site 279010004068 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010004069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010004070 dimer interface [polypeptide binding]; other site 279010004071 conserved gate region; other site 279010004072 putative PBP binding loops; other site 279010004073 ABC-ATPase subunit interface; other site 279010004074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279010004075 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 279010004076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010004077 putative PBP binding loops; other site 279010004078 dimer interface [polypeptide binding]; other site 279010004079 ABC-ATPase subunit interface; other site 279010004080 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010004081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010004082 Walker A/P-loop; other site 279010004083 ATP binding site [chemical binding]; other site 279010004084 Q-loop/lid; other site 279010004085 ABC transporter signature motif; other site 279010004086 Walker B; other site 279010004087 D-loop; other site 279010004088 H-loop/switch region; other site 279010004089 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 279010004090 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 279010004091 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 279010004092 peptide binding site [polypeptide binding]; other site 279010004093 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 279010004094 dimer interface [polypeptide binding]; other site 279010004095 catalytic triad [active] 279010004096 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 279010004097 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 279010004098 active site 279010004099 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010004100 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010004101 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 279010004102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010004103 Walker A/P-loop; other site 279010004104 ATP binding site [chemical binding]; other site 279010004105 Q-loop/lid; other site 279010004106 ABC transporter signature motif; other site 279010004107 Walker B; other site 279010004108 D-loop; other site 279010004109 H-loop/switch region; other site 279010004110 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 279010004111 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 279010004112 Amidinotransferase; Region: Amidinotransf; pfam02274 279010004113 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 279010004114 Predicted membrane protein [Function unknown]; Region: COG2323 279010004115 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 279010004116 Amb_all domain; Region: Amb_all; smart00656 279010004117 Predicted transcriptional regulators [Transcription]; Region: COG1695 279010004118 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 279010004119 hypothetical protein; Validated; Region: PRK07668 279010004120 DinB superfamily; Region: DinB_2; pfam12867 279010004121 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279010004122 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279010004123 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 279010004124 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 279010004125 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 279010004126 putative active site [active] 279010004127 putative substrate binding site [chemical binding]; other site 279010004128 putative cosubstrate binding site; other site 279010004129 catalytic site [active] 279010004130 gamma-glutamyl kinase; Provisional; Region: PRK05429 279010004131 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 279010004132 nucleotide binding site [chemical binding]; other site 279010004133 homotetrameric interface [polypeptide binding]; other site 279010004134 putative phosphate binding site [ion binding]; other site 279010004135 putative allosteric binding site; other site 279010004136 PUA domain; Region: PUA; pfam01472 279010004137 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 279010004138 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 279010004139 putative catalytic cysteine [active] 279010004140 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 279010004141 Transcriptional regulators [Transcription]; Region: MarR; COG1846 279010004142 MarR family; Region: MarR; pfam01047 279010004143 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 279010004144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 279010004145 nucleoside/Zn binding site; other site 279010004146 dimer interface [polypeptide binding]; other site 279010004147 catalytic motif [active] 279010004148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279010004149 catalytic core [active] 279010004150 Proteins of 100 residues with WXG; Region: WXG100; cl02005 279010004151 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 279010004152 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 279010004153 THF binding site; other site 279010004154 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 279010004155 substrate binding site [chemical binding]; other site 279010004156 THF binding site; other site 279010004157 zinc-binding site [ion binding]; other site 279010004158 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 279010004159 active site 279010004160 catalytic residues [active] 279010004161 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 279010004162 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 279010004163 MgtE intracellular N domain; Region: MgtE_N; smart00924 279010004164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 279010004165 Divalent cation transporter; Region: MgtE; pfam01769 279010004166 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279010004167 Int/Topo IB signature motif; other site 279010004168 Domain of unknown function (DUF955); Region: DUF955; pfam06114 279010004169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004170 non-specific DNA binding site [nucleotide binding]; other site 279010004171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010004172 sequence-specific DNA binding site [nucleotide binding]; other site 279010004173 salt bridge; other site 279010004174 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010004175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004176 non-specific DNA binding site [nucleotide binding]; other site 279010004177 salt bridge; other site 279010004178 sequence-specific DNA binding site [nucleotide binding]; other site 279010004179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004180 non-specific DNA binding site [nucleotide binding]; other site 279010004181 salt bridge; other site 279010004182 sequence-specific DNA binding site [nucleotide binding]; other site 279010004183 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 279010004184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004185 non-specific DNA binding site [nucleotide binding]; other site 279010004186 salt bridge; other site 279010004187 sequence-specific DNA binding site [nucleotide binding]; other site 279010004188 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 279010004189 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 279010004190 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 279010004191 hypothetical protein; Provisional; Region: PRK06921 279010004192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010004193 Walker A motif; other site 279010004194 ATP binding site [chemical binding]; other site 279010004195 Walker B motif; other site 279010004196 arginine finger; other site 279010004197 A short protein domain of unknown function; Region: IDEAL; smart00914 279010004198 YopX protein; Region: YopX; pfam09643 279010004199 YopX protein; Region: YopX; pfam09643 279010004200 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 279010004201 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279010004202 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279010004203 dimer interface [polypeptide binding]; other site 279010004204 ssDNA binding site [nucleotide binding]; other site 279010004205 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279010004206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 279010004207 Uncharacterized conserved protein [Function unknown]; Region: COG5484 279010004208 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 279010004209 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 279010004210 Terminase-like family; Region: Terminase_6; pfam03237 279010004211 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 279010004212 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 279010004213 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 279010004214 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 279010004215 Phage capsid family; Region: Phage_capsid; pfam05065 279010004216 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 279010004217 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 279010004218 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 279010004219 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 279010004220 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 279010004221 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010004222 Interdomain contacts; other site 279010004223 Cytokine receptor motif; other site 279010004224 Phage protein; Region: DUF3647; pfam12363 279010004225 Phage-related protein [Function unknown]; Region: COG5412 279010004226 membrane protein P6; Region: PHA01399 279010004227 Phage-related protein [Function unknown]; Region: COG4722 279010004228 Phage tail protein; Region: Sipho_tail; pfam05709 279010004229 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 279010004230 Haemolysin XhlA; Region: XhlA; pfam10779 279010004231 holin, SPP1 family; Region: holin_SPP1; TIGR01592 279010004232 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 279010004233 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 279010004234 active site 279010004235 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010004236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010004237 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 279010004238 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 279010004239 Uncharacterized conserved protein [Function unknown]; Region: COG1633 279010004240 dinuclear metal binding motif [ion binding]; other site 279010004241 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 279010004242 diiron binding motif [ion binding]; other site 279010004243 Predicted membrane protein [Function unknown]; Region: COG2323 279010004244 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 279010004245 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010004246 DNA binding residues [nucleotide binding] 279010004247 putative dimer interface [polypeptide binding]; other site 279010004248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010004249 MarR family; Region: MarR; pfam01047 279010004250 MarR family; Region: MarR_2; cl17246 279010004251 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 279010004252 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 279010004253 active site 279010004254 DNA binding site [nucleotide binding] 279010004255 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 279010004256 nucleotide binding site [chemical binding]; other site 279010004257 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 279010004258 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 279010004259 putative DNA binding site [nucleotide binding]; other site 279010004260 putative homodimer interface [polypeptide binding]; other site 279010004261 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 279010004262 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 279010004263 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 279010004264 PAS domain S-box; Region: sensory_box; TIGR00229 279010004265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 279010004266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010004267 metal binding site [ion binding]; metal-binding site 279010004268 active site 279010004269 I-site; other site 279010004270 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 279010004271 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279010004272 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 279010004273 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 279010004274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004275 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 279010004276 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010004277 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 279010004278 heat shock protein HtpX; Provisional; Region: PRK05457 279010004279 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 279010004280 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279010004281 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 279010004282 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010004283 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010004285 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 279010004286 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279010004287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004288 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 279010004289 putative active site [active] 279010004290 heme pocket [chemical binding]; other site 279010004291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004292 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 279010004293 putative active site [active] 279010004294 heme pocket [chemical binding]; other site 279010004295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004296 putative active site [active] 279010004297 heme pocket [chemical binding]; other site 279010004298 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010004299 PAS domain; Region: PAS; smart00091 279010004300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004301 dimer interface [polypeptide binding]; other site 279010004302 phosphorylation site [posttranslational modification] 279010004303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004304 ATP binding site [chemical binding]; other site 279010004305 Mg2+ binding site [ion binding]; other site 279010004306 G-X-G motif; other site 279010004307 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 279010004308 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 279010004309 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 279010004310 DNA binding site [nucleotide binding] 279010004311 active site 279010004312 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 279010004313 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 279010004314 Phosphotransferase enzyme family; Region: APH; pfam01636 279010004315 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 279010004316 substrate binding site [chemical binding]; other site 279010004317 Predicted amidohydrolase [General function prediction only]; Region: COG0388 279010004318 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 279010004319 putative active site [active] 279010004320 catalytic triad [active] 279010004321 putative dimer interface [polypeptide binding]; other site 279010004322 transaminase; Reviewed; Region: PRK08068 279010004323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010004324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010004325 homodimer interface [polypeptide binding]; other site 279010004326 catalytic residue [active] 279010004327 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 279010004328 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 279010004329 dimer interface [polypeptide binding]; other site 279010004330 active site 279010004331 catalytic residue [active] 279010004332 metal binding site [ion binding]; metal-binding site 279010004333 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 279010004334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004335 motif II; other site 279010004336 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 279010004337 intersubunit interface [polypeptide binding]; other site 279010004338 active site 279010004339 Zn2+ binding site [ion binding]; other site 279010004340 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 279010004341 Cupin domain; Region: Cupin_2; pfam07883 279010004342 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 279010004343 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010004344 active site 279010004345 metal binding site [ion binding]; metal-binding site 279010004346 Uncharacterized conserved protein [Function unknown]; Region: COG3339 279010004347 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 279010004348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004349 dimer interface [polypeptide binding]; other site 279010004350 phosphorylation site [posttranslational modification] 279010004351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004352 ATP binding site [chemical binding]; other site 279010004353 Mg2+ binding site [ion binding]; other site 279010004354 G-X-G motif; other site 279010004355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010004356 MarR family; Region: MarR; pfam01047 279010004357 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 279010004358 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 279010004359 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 279010004360 ligand binding site [chemical binding]; other site 279010004361 flagellar motor protein MotA; Validated; Region: PRK08124 279010004362 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 279010004363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010004364 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010004365 Walker A motif; other site 279010004366 ATP binding site [chemical binding]; other site 279010004367 Walker B motif; other site 279010004368 arginine finger; other site 279010004369 UvrB/uvrC motif; Region: UVR; pfam02151 279010004370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010004371 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010004372 Walker A motif; other site 279010004373 ATP binding site [chemical binding]; other site 279010004374 Walker B motif; other site 279010004375 arginine finger; other site 279010004376 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 279010004377 Uncharacterized membrane protein [Function unknown]; Region: COG3949 279010004378 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 279010004379 Ligand Binding Site [chemical binding]; other site 279010004380 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 279010004381 active site 279010004382 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 279010004383 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 279010004384 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 279010004385 putative phage Bli_Pp4 279010004386 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 279010004387 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010004388 active site 279010004389 DNA binding site [nucleotide binding] 279010004390 Int/Topo IB signature motif; other site 279010004391 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 279010004392 DNA binding site [nucleotide binding] 279010004393 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010004394 DNA binding site [nucleotide binding] 279010004395 active site 279010004396 Int/Topo IB signature motif; other site 279010004397 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 279010004398 nucleophilic elbow; other site 279010004399 catalytic triad; other site 279010004400 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 279010004401 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 279010004402 active site 279010004403 DNA binding site [nucleotide binding] 279010004404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004405 non-specific DNA binding site [nucleotide binding]; other site 279010004406 salt bridge; other site 279010004407 sequence-specific DNA binding site [nucleotide binding]; other site 279010004408 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 279010004409 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 279010004410 active site 279010004411 Phage terminase, small subunit; Region: Terminase_4; pfam05119 279010004412 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 279010004413 Phage-related protein [Function unknown]; Region: COG4695 279010004414 Phage portal protein; Region: Phage_portal; pfam04860 279010004415 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 279010004416 oligomer interface [polypeptide binding]; other site 279010004417 Clp protease; Region: CLP_protease; pfam00574 279010004418 active site residues [active] 279010004419 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 279010004420 Phage capsid family; Region: Phage_capsid; pfam05065 279010004421 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010004422 Interdomain contacts; other site 279010004423 Cytokine receptor motif; other site 279010004424 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 279010004425 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 279010004426 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 279010004427 oligomerization interface [polypeptide binding]; other site 279010004428 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 279010004429 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 279010004430 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010004431 Interdomain contacts; other site 279010004432 Cytokine receptor motif; other site 279010004433 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 279010004434 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 279010004435 Phage-related protein [Function unknown]; Region: COG5412 279010004436 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279010004437 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010004438 catalytic residue [active] 279010004439 Phage tail protein; Region: Sipho_tail; pfam05709 279010004440 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 279010004441 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279010004442 Right handed beta helix region; Region: Beta_helix; pfam13229 279010004443 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 279010004444 XkdW protein; Region: XkdW; pfam09636 279010004445 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 279010004446 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010004447 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279010004448 active site 279010004449 catalytic site [active] 279010004450 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 279010004451 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 279010004452 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279010004453 amidase catalytic site [active] 279010004454 Zn binding residues [ion binding]; other site 279010004455 substrate binding site [chemical binding]; other site 279010004456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010004457 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 279010004458 Phage holin; Region: Phage_holin_5; pfam06946 279010004459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004460 non-specific DNA binding site [nucleotide binding]; other site 279010004461 salt bridge; other site 279010004462 sequence-specific DNA binding site [nucleotide binding]; other site 279010004463 Helix-turn-helix domain; Region: HTH_36; pfam13730 279010004464 YolD-like protein; Region: YolD; pfam08863 279010004465 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 279010004466 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279010004467 Int/Topo IB signature motif; other site 279010004468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 279010004469 binding surface 279010004470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010004471 TPR motif; other site 279010004472 Protein of unknown function (DUF817); Region: DUF817; pfam05675 279010004473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010004474 salt bridge; other site 279010004475 non-specific DNA binding site [nucleotide binding]; other site 279010004476 sequence-specific DNA binding site [nucleotide binding]; other site 279010004477 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 279010004478 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 279010004479 nucleophilic elbow; other site 279010004480 catalytic triad; other site 279010004481 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 279010004482 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 279010004483 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 279010004484 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 279010004485 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 279010004486 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010004487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279010004488 catalytic residues [active] 279010004489 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 279010004490 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004492 motif II; other site 279010004493 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 279010004494 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 279010004495 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 279010004496 active site 279010004497 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 279010004498 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010004499 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010004500 DNA binding site [nucleotide binding] 279010004501 domain linker motif; other site 279010004502 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 279010004503 putative dimerization interface [polypeptide binding]; other site 279010004504 putative ligand binding site [chemical binding]; other site 279010004505 CAT RNA binding domain; Region: CAT_RBD; smart01061 279010004506 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010004507 PRD domain; Region: PRD; pfam00874 279010004508 PRD domain; Region: PRD; pfam00874 279010004509 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010004510 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 279010004511 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010004512 active site turn [active] 279010004513 phosphorylation site [posttranslational modification] 279010004514 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 279010004515 HPr interaction site; other site 279010004516 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010004517 active site 279010004518 phosphorylation site [posttranslational modification] 279010004519 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279010004520 dimerization domain swap beta strand [polypeptide binding]; other site 279010004521 regulatory protein interface [polypeptide binding]; other site 279010004522 active site 279010004523 regulatory phosphorylation site [posttranslational modification]; other site 279010004524 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 279010004525 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 279010004526 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 279010004527 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 279010004528 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 279010004529 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 279010004530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010004531 FeS/SAM binding site; other site 279010004532 putative acetyltransferase; Provisional; Region: PRK03624 279010004533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010004534 Coenzyme A binding pocket [chemical binding]; other site 279010004535 Cache domain; Region: Cache_1; pfam02743 279010004536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010004537 dimerization interface [polypeptide binding]; other site 279010004538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010004539 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010004540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010004541 dimer interface [polypeptide binding]; other site 279010004542 putative CheW interface [polypeptide binding]; other site 279010004543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010004544 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 279010004545 putative NAD(P) binding site [chemical binding]; other site 279010004546 putative active site [active] 279010004547 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 279010004548 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 279010004549 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 279010004550 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 279010004551 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004552 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004553 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010004554 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010004555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004556 PAS fold; Region: PAS_3; pfam08447 279010004557 putative active site [active] 279010004558 heme pocket [chemical binding]; other site 279010004559 PAS fold; Region: PAS; pfam00989 279010004560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004561 putative active site [active] 279010004562 heme pocket [chemical binding]; other site 279010004563 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010004564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004565 putative active site [active] 279010004566 heme pocket [chemical binding]; other site 279010004567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004568 dimer interface [polypeptide binding]; other site 279010004569 phosphorylation site [posttranslational modification] 279010004570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004571 ATP binding site [chemical binding]; other site 279010004572 Mg2+ binding site [ion binding]; other site 279010004573 G-X-G motif; other site 279010004574 aminotransferase A; Validated; Region: PRK07683 279010004575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010004576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010004577 homodimer interface [polypeptide binding]; other site 279010004578 catalytic residue [active] 279010004579 RDD family; Region: RDD; pfam06271 279010004580 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 279010004581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010004582 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 279010004583 putative CheA interaction surface; other site 279010004584 Response regulator receiver domain; Region: Response_reg; pfam00072 279010004585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010004586 active site 279010004587 phosphorylation site [posttranslational modification] 279010004588 intermolecular recognition site; other site 279010004589 dimerization interface [polypeptide binding]; other site 279010004590 YkyB-like protein; Region: YkyB; pfam14177 279010004591 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010004592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010004593 putative substrate translocation pore; other site 279010004594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 279010004595 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010004596 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 279010004597 phosphodiesterase YaeI; Provisional; Region: PRK11340 279010004598 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 279010004599 putative active site [active] 279010004600 putative metal binding site [ion binding]; other site 279010004601 short chain dehydrogenase; Provisional; Region: PRK07677 279010004602 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 279010004603 NAD(P) binding site [chemical binding]; other site 279010004604 substrate binding site [chemical binding]; other site 279010004605 homotetramer interface [polypeptide binding]; other site 279010004606 active site 279010004607 homodimer interface [polypeptide binding]; other site 279010004608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 279010004609 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 279010004610 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 279010004611 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 279010004612 Protein of unknown function (DUF458); Region: DUF458; pfam04308 279010004613 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 279010004614 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 279010004615 FOG: CBS domain [General function prediction only]; Region: COG0517 279010004616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010004617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010004618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010004619 dimerization interface [polypeptide binding]; other site 279010004620 flavodoxin; Provisional; Region: PRK06703 279010004621 BNR repeat-like domain; Region: BNR_2; pfam13088 279010004622 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 279010004623 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 279010004624 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 279010004625 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 279010004626 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 279010004627 active site 279010004628 trimer interface [polypeptide binding]; other site 279010004629 substrate binding site [chemical binding]; other site 279010004630 CoA binding site [chemical binding]; other site 279010004631 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010004632 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 279010004633 metal binding site [ion binding]; metal-binding site 279010004634 putative dimer interface [polypeptide binding]; other site 279010004635 hypothetical protein; Provisional; Region: PRK03094 279010004636 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 279010004637 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 279010004638 dimer interface [polypeptide binding]; other site 279010004639 decamer (pentamer of dimers) interface [polypeptide binding]; other site 279010004640 catalytic triad [active] 279010004641 peroxidatic and resolving cysteines [active] 279010004642 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010004643 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279010004644 catalytic residues [active] 279010004645 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010004646 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 279010004647 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 279010004648 GTP binding site; other site 279010004649 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 279010004650 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 279010004651 ATP binding site [chemical binding]; other site 279010004652 substrate interface [chemical binding]; other site 279010004653 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 279010004654 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 279010004655 dimer interface [polypeptide binding]; other site 279010004656 putative functional site; other site 279010004657 putative MPT binding site; other site 279010004658 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 279010004659 Walker A motif; other site 279010004660 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 279010004661 MoaE homodimer interface [polypeptide binding]; other site 279010004662 MoaD interaction [polypeptide binding]; other site 279010004663 active site residues [active] 279010004664 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 279010004665 MoaE interaction surface [polypeptide binding]; other site 279010004666 MoeB interaction surface [polypeptide binding]; other site 279010004667 thiocarboxylated glycine; other site 279010004668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010004669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010004670 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 279010004671 Walker A/P-loop; other site 279010004672 ATP binding site [chemical binding]; other site 279010004673 Q-loop/lid; other site 279010004674 ABC transporter signature motif; other site 279010004675 Walker B; other site 279010004676 D-loop; other site 279010004677 H-loop/switch region; other site 279010004678 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010004679 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010004680 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 279010004681 Walker A/P-loop; other site 279010004682 ATP binding site [chemical binding]; other site 279010004683 Q-loop/lid; other site 279010004684 ABC transporter signature motif; other site 279010004685 Walker B; other site 279010004686 D-loop; other site 279010004687 H-loop/switch region; other site 279010004688 Yip1 domain; Region: Yip1; pfam04893 279010004689 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 279010004690 HlyD family secretion protein; Region: HlyD_3; pfam13437 279010004691 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010004692 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279010004693 Walker A/P-loop; other site 279010004694 ATP binding site [chemical binding]; other site 279010004695 Q-loop/lid; other site 279010004696 ABC transporter signature motif; other site 279010004697 Walker B; other site 279010004698 D-loop; other site 279010004699 H-loop/switch region; other site 279010004700 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279010004701 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010004702 FtsX-like permease family; Region: FtsX; pfam02687 279010004703 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010004704 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 279010004705 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 279010004706 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 279010004707 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 279010004708 putative substrate binding site [chemical binding]; other site 279010004709 putative ATP binding site [chemical binding]; other site 279010004710 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 279010004711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010004712 active site 279010004713 phosphorylation site [posttranslational modification] 279010004714 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279010004715 active site 279010004716 P-loop; other site 279010004717 phosphorylation site [posttranslational modification] 279010004718 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 279010004719 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279010004720 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279010004721 Catalytic site [active] 279010004722 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 279010004723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010004724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010004725 ABC transporter; Region: ABC_tran_2; pfam12848 279010004726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010004727 SnoaL-like domain; Region: SnoaL_3; pfam13474 279010004728 SnoaL-like domain; Region: SnoaL_2; pfam12680 279010004729 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 279010004730 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 279010004731 rod-share determining protein MreBH; Provisional; Region: PRK13929 279010004732 MreB and similar proteins; Region: MreB_like; cd10225 279010004733 nucleotide binding site [chemical binding]; other site 279010004734 Mg binding site [ion binding]; other site 279010004735 putative protofilament interaction site [polypeptide binding]; other site 279010004736 RodZ interaction site [polypeptide binding]; other site 279010004737 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 279010004738 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 279010004739 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 279010004740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004741 putative active site [active] 279010004742 heme pocket [chemical binding]; other site 279010004743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004744 dimer interface [polypeptide binding]; other site 279010004745 phosphorylation site [posttranslational modification] 279010004746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004747 ATP binding site [chemical binding]; other site 279010004748 Mg2+ binding site [ion binding]; other site 279010004749 G-X-G motif; other site 279010004750 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279010004751 TrkA-N domain; Region: TrkA_N; pfam02254 279010004752 TrkA-C domain; Region: TrkA_C; pfam02080 279010004753 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 279010004754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010004755 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 279010004756 active site 279010004757 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 279010004758 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 279010004759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 279010004760 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 279010004761 hypothetical protein; Provisional; Region: PRK13667 279010004762 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 279010004763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004764 active site 279010004765 motif I; other site 279010004766 motif II; other site 279010004767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004768 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 279010004769 active site 279010004770 catalytic residues [active] 279010004771 metal binding site [ion binding]; metal-binding site 279010004772 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 279010004773 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 279010004774 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279010004775 TPP-binding site [chemical binding]; other site 279010004776 tetramer interface [polypeptide binding]; other site 279010004777 heterodimer interface [polypeptide binding]; other site 279010004778 phosphorylation loop region [posttranslational modification] 279010004779 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279010004780 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279010004781 alpha subunit interface [polypeptide binding]; other site 279010004782 TPP binding site [chemical binding]; other site 279010004783 heterodimer interface [polypeptide binding]; other site 279010004784 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010004785 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279010004786 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010004787 E3 interaction surface; other site 279010004788 lipoyl attachment site [posttranslational modification]; other site 279010004789 e3 binding domain; Region: E3_binding; pfam02817 279010004790 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279010004791 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 279010004792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279010004793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010004794 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279010004795 Transposase; Region: HTH_Tnp_1; cl17663 279010004796 putative transposase OrfB; Reviewed; Region: PHA02517 279010004797 HTH-like domain; Region: HTH_21; pfam13276 279010004798 Integrase core domain; Region: rve; pfam00665 279010004799 Integrase core domain; Region: rve_3; pfam13683 279010004800 Homeodomain-like domain; Region: HTH_23; pfam13384 279010004801 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 279010004802 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 279010004803 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 279010004804 homodimer interface [polypeptide binding]; other site 279010004805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010004806 catalytic residue [active] 279010004807 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 279010004808 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 279010004809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 279010004810 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 279010004811 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 279010004812 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 279010004813 active site 279010004814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010004815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010004816 Coenzyme A binding pocket [chemical binding]; other site 279010004817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004818 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 279010004819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010004820 DNA binding residues [nucleotide binding] 279010004821 Putative zinc-finger; Region: zf-HC2; pfam13490 279010004822 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 279010004823 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 279010004824 G1 box; other site 279010004825 putative GEF interaction site [polypeptide binding]; other site 279010004826 GTP/Mg2+ binding site [chemical binding]; other site 279010004827 Switch I region; other site 279010004828 G2 box; other site 279010004829 G3 box; other site 279010004830 Switch II region; other site 279010004831 G4 box; other site 279010004832 G5 box; other site 279010004833 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 279010004834 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 279010004835 YlaH-like protein; Region: YlaH; pfam14036 279010004836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010004837 MarR family; Region: MarR; pfam01047 279010004838 hypothetical protein; Provisional; Region: PRK08244 279010004839 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 279010004840 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 279010004841 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 279010004842 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010004843 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 279010004844 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 279010004845 putative active site [active] 279010004846 PhoH-like protein; Region: PhoH; pfam02562 279010004847 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 279010004848 glutaminase A; Region: Gln_ase; TIGR03814 279010004849 hypothetical protein; Provisional; Region: PRK13666 279010004850 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 279010004851 pyruvate carboxylase; Reviewed; Region: PRK12999 279010004852 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010004853 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279010004854 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 279010004855 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 279010004856 active site 279010004857 catalytic residues [active] 279010004858 metal binding site [ion binding]; metal-binding site 279010004859 homodimer binding site [polypeptide binding]; other site 279010004860 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010004861 carboxyltransferase (CT) interaction site; other site 279010004862 biotinylation site [posttranslational modification]; other site 279010004863 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 279010004864 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 279010004865 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 279010004866 UbiA prenyltransferase family; Region: UbiA; pfam01040 279010004867 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 279010004868 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 279010004869 Cytochrome c; Region: Cytochrom_C; pfam00034 279010004870 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 279010004871 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 279010004872 D-pathway; other site 279010004873 Putative ubiquinol binding site [chemical binding]; other site 279010004874 Low-spin heme (heme b) binding site [chemical binding]; other site 279010004875 Putative water exit pathway; other site 279010004876 Binuclear center (heme o3/CuB) [ion binding]; other site 279010004877 K-pathway; other site 279010004878 Putative proton exit pathway; other site 279010004879 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 279010004880 Subunit I/III interface [polypeptide binding]; other site 279010004881 Subunit III/IV interface [polypeptide binding]; other site 279010004882 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 279010004883 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 279010004884 YugN-like family; Region: YugN; pfam08868 279010004885 FOG: CBS domain [General function prediction only]; Region: COG0517 279010004886 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 279010004887 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 279010004888 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 279010004889 Putative coat protein; Region: YlbD_coat; pfam14071 279010004890 YlbE-like protein; Region: YlbE; pfam14003 279010004891 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 279010004892 hypothetical protein; Provisional; Region: PRK02886 279010004893 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 279010004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010004895 S-adenosylmethionine binding site [chemical binding]; other site 279010004896 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 279010004897 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 279010004898 active site 279010004899 (T/H)XGH motif; other site 279010004900 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 279010004901 Nucleoside recognition; Region: Gate; pfam07670 279010004902 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 279010004903 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 279010004904 protein binding site [polypeptide binding]; other site 279010004905 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 279010004906 hypothetical protein; Provisional; Region: PRK13670 279010004907 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 279010004908 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 279010004909 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 279010004910 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 279010004911 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 279010004912 hypothetical protein; Provisional; Region: PRK13688 279010004913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010004914 Coenzyme A binding pocket [chemical binding]; other site 279010004915 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 279010004916 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 279010004917 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 279010004918 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 279010004919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 279010004920 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 279010004921 mraZ protein; Region: TIGR00242 279010004922 MraZ protein; Region: MraZ; pfam02381 279010004923 MraZ protein; Region: MraZ; pfam02381 279010004924 MraW methylase family; Region: Methyltransf_5; pfam01795 279010004925 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 279010004926 Cell division protein FtsL; Region: FtsL; cl11433 279010004927 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010004928 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010004930 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 279010004931 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 279010004932 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 279010004933 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010004935 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 279010004936 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 279010004937 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279010004938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010004939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010004940 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 279010004941 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 279010004942 Mg++ binding site [ion binding]; other site 279010004943 putative catalytic motif [active] 279010004944 putative substrate binding site [chemical binding]; other site 279010004945 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 279010004946 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010004947 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010004948 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010004949 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 279010004950 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 279010004951 active site 279010004952 homodimer interface [polypeptide binding]; other site 279010004953 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 279010004954 FAD binding domain; Region: FAD_binding_4; pfam01565 279010004955 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 279010004956 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 279010004957 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 279010004958 Cell division protein FtsQ; Region: FtsQ; pfam03799 279010004959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 279010004960 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 279010004961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 279010004962 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 279010004963 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 279010004964 cell division protein FtsA; Region: ftsA; TIGR01174 279010004965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010004966 nucleotide binding site [chemical binding]; other site 279010004967 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 279010004968 Cell division protein FtsA; Region: FtsA; pfam14450 279010004969 cell division protein FtsZ; Validated; Region: PRK09330 279010004970 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 279010004971 nucleotide binding site [chemical binding]; other site 279010004972 SulA interaction site; other site 279010004973 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010004974 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 279010004975 active site 279010004976 catalytic triad [active] 279010004977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 279010004978 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 279010004979 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 279010004980 Cna protein B-type domain; Region: Cna_B_2; pfam13715 279010004981 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 279010004982 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 279010004983 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 279010004984 sporulation sigma factor SigE; Reviewed; Region: PRK08301 279010004985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010004987 DNA binding residues [nucleotide binding] 279010004988 sporulation sigma factor SigG; Reviewed; Region: PRK08215 279010004989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004990 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010004991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010004992 DNA binding residues [nucleotide binding] 279010004993 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010004994 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279010004995 Walker A/P-loop; other site 279010004996 ATP binding site [chemical binding]; other site 279010004997 Q-loop/lid; other site 279010004998 ABC transporter signature motif; other site 279010004999 Walker B; other site 279010005000 D-loop; other site 279010005001 H-loop/switch region; other site 279010005002 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 279010005003 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 279010005004 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 279010005005 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 279010005006 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010005007 catalytic residue [active] 279010005008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 279010005009 YGGT family; Region: YGGT; pfam02325 279010005010 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 279010005011 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010005012 RNA binding surface [nucleotide binding]; other site 279010005013 DivIVA protein; Region: DivIVA; pfam05103 279010005014 DivIVA domain; Region: DivI1A_domain; TIGR03544 279010005015 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 279010005016 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 279010005017 HIGH motif; other site 279010005018 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279010005019 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 279010005020 active site 279010005021 KMSKS motif; other site 279010005022 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 279010005023 tRNA binding surface [nucleotide binding]; other site 279010005024 anticodon binding site; other site 279010005025 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 279010005026 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 279010005027 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 279010005028 lipoprotein signal peptidase; Provisional; Region: PRK14787 279010005029 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 279010005030 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010005031 RNA binding surface [nucleotide binding]; other site 279010005032 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 279010005033 active site 279010005034 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 279010005035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010005036 active site 279010005037 uracil transporter; Provisional; Region: PRK10720 279010005038 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 279010005039 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279010005040 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 279010005041 dihydroorotase; Validated; Region: pyrC; PRK09357 279010005042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010005043 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 279010005044 active site 279010005045 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 279010005046 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 279010005047 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 279010005048 catalytic site [active] 279010005049 subunit interface [polypeptide binding]; other site 279010005050 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 279010005051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010005052 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279010005053 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 279010005054 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010005055 ATP-grasp domain; Region: ATP-grasp_4; cl17255 279010005056 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 279010005057 IMP binding site; other site 279010005058 dimer interface [polypeptide binding]; other site 279010005059 interdomain contacts; other site 279010005060 partial ornithine binding site; other site 279010005061 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 279010005062 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 279010005063 FAD binding pocket [chemical binding]; other site 279010005064 FAD binding motif [chemical binding]; other site 279010005065 phosphate binding motif [ion binding]; other site 279010005066 beta-alpha-beta structure motif; other site 279010005067 NAD binding pocket [chemical binding]; other site 279010005068 Iron coordination center [ion binding]; other site 279010005069 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 279010005070 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 279010005071 heterodimer interface [polypeptide binding]; other site 279010005072 active site 279010005073 FMN binding site [chemical binding]; other site 279010005074 homodimer interface [polypeptide binding]; other site 279010005075 substrate binding site [chemical binding]; other site 279010005076 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 279010005077 active site 279010005078 dimer interface [polypeptide binding]; other site 279010005079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010005080 active site 279010005081 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 279010005082 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 279010005083 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 279010005084 Active Sites [active] 279010005085 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 279010005086 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 279010005087 ATP-sulfurylase; Region: ATPS; cd00517 279010005088 active site 279010005089 HXXH motif; other site 279010005090 flexible loop; other site 279010005091 AAA domain; Region: AAA_33; pfam13671 279010005092 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 279010005093 ligand-binding site [chemical binding]; other site 279010005094 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 279010005095 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 279010005096 active site 279010005097 SAM binding site [chemical binding]; other site 279010005098 homodimer interface [polypeptide binding]; other site 279010005099 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 279010005100 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 279010005101 putative active site [active] 279010005102 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 279010005103 putative active site [active] 279010005104 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 279010005105 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 279010005106 Domain of unknown function (DUF814); Region: DUF814; pfam05670 279010005107 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 279010005108 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 279010005109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010005110 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 279010005111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010005112 motif II; other site 279010005113 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 279010005114 hypothetical protein; Provisional; Region: PRK11820 279010005115 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 279010005116 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 279010005117 hypothetical protein; Provisional; Region: PRK04323 279010005118 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 279010005119 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 279010005120 catalytic site [active] 279010005121 G-X2-G-X-G-K; other site 279010005122 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 279010005123 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 279010005124 Flavoprotein; Region: Flavoprotein; pfam02441 279010005125 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 279010005126 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 279010005127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010005128 ATP binding site [chemical binding]; other site 279010005129 putative Mg++ binding site [ion binding]; other site 279010005130 helicase superfamily c-terminal domain; Region: HELICc; smart00490 279010005131 nucleotide binding region [chemical binding]; other site 279010005132 ATP-binding site [chemical binding]; other site 279010005133 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 279010005134 active site 279010005135 catalytic residues [active] 279010005136 metal binding site [ion binding]; metal-binding site 279010005137 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 279010005138 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 279010005139 putative active site [active] 279010005140 substrate binding site [chemical binding]; other site 279010005141 putative cosubstrate binding site; other site 279010005142 catalytic site [active] 279010005143 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 279010005144 substrate binding site [chemical binding]; other site 279010005145 16S rRNA methyltransferase B; Provisional; Region: PRK14902 279010005146 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 279010005147 putative RNA binding site [nucleotide binding]; other site 279010005148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010005149 S-adenosylmethionine binding site [chemical binding]; other site 279010005150 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 279010005151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010005152 FeS/SAM binding site; other site 279010005153 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 279010005154 Protein phosphatase 2C; Region: PP2C; pfam00481 279010005155 active site 279010005156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010005157 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 279010005158 active site 279010005159 ATP binding site [chemical binding]; other site 279010005160 substrate binding site [chemical binding]; other site 279010005161 activation loop (A-loop); other site 279010005162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 279010005163 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279010005164 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279010005165 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279010005166 GTPase RsgA; Reviewed; Region: PRK00098 279010005167 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 279010005168 RNA binding site [nucleotide binding]; other site 279010005169 homodimer interface [polypeptide binding]; other site 279010005170 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 279010005171 GTPase/Zn-binding domain interface [polypeptide binding]; other site 279010005172 GTP/Mg2+ binding site [chemical binding]; other site 279010005173 G4 box; other site 279010005174 G5 box; other site 279010005175 G1 box; other site 279010005176 Switch I region; other site 279010005177 G2 box; other site 279010005178 G3 box; other site 279010005179 Switch II region; other site 279010005180 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 279010005181 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 279010005182 substrate binding site [chemical binding]; other site 279010005183 hexamer interface [polypeptide binding]; other site 279010005184 metal binding site [ion binding]; metal-binding site 279010005185 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 279010005186 Thiamine pyrophosphokinase; Region: TPK; cd07995 279010005187 active site 279010005188 dimerization interface [polypeptide binding]; other site 279010005189 thiamine binding site [chemical binding]; other site 279010005190 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 279010005191 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 279010005192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 279010005193 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 279010005194 DAK2 domain; Region: Dak2; pfam02734 279010005195 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 279010005196 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 279010005197 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 279010005198 putative L-serine binding site [chemical binding]; other site 279010005199 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 279010005200 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 279010005201 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 279010005202 Y-family of DNA polymerases; Region: PolY; cl12025 279010005203 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 279010005204 generic binding surface II; other site 279010005205 ssDNA binding site; other site 279010005206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010005207 ATP binding site [chemical binding]; other site 279010005208 putative Mg++ binding site [ion binding]; other site 279010005209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010005210 nucleotide binding region [chemical binding]; other site 279010005211 ATP-binding site [chemical binding]; other site 279010005212 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 279010005213 HTH domain; Region: HTH_11; cl17392 279010005214 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 279010005215 putative phosphate acyltransferase; Provisional; Region: PRK05331 279010005216 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 279010005217 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 279010005218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 279010005219 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 279010005220 NAD(P) binding site [chemical binding]; other site 279010005221 homotetramer interface [polypeptide binding]; other site 279010005222 homodimer interface [polypeptide binding]; other site 279010005223 active site 279010005224 acyl carrier protein; Provisional; Region: acpP; PRK00982 279010005225 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 279010005226 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 279010005227 dimerization interface [polypeptide binding]; other site 279010005228 active site 279010005229 metal binding site [ion binding]; metal-binding site 279010005230 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 279010005231 dsRNA binding site [nucleotide binding]; other site 279010005232 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010005233 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 279010005234 Walker A/P-loop; other site 279010005235 ATP binding site [chemical binding]; other site 279010005236 Q-loop/lid; other site 279010005237 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 279010005238 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 279010005239 Q-loop/lid; other site 279010005240 ABC transporter signature motif; other site 279010005241 Walker B; other site 279010005242 D-loop; other site 279010005243 H-loop/switch region; other site 279010005244 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 279010005245 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 279010005246 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 279010005247 P loop; other site 279010005248 GTP binding site [chemical binding]; other site 279010005249 putative DNA-binding protein; Validated; Region: PRK00118 279010005250 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 279010005251 signal recognition particle protein; Provisional; Region: PRK10867 279010005252 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 279010005253 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 279010005254 P loop; other site 279010005255 GTP binding site [chemical binding]; other site 279010005256 Signal peptide binding domain; Region: SRP_SPB; pfam02978 279010005257 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 279010005258 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 279010005259 KH domain; Region: KH_4; pfam13083 279010005260 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 279010005261 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 279010005262 RimM N-terminal domain; Region: RimM; pfam01782 279010005263 PRC-barrel domain; Region: PRC; pfam05239 279010005264 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 279010005265 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 279010005266 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 279010005267 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 279010005268 GTP/Mg2+ binding site [chemical binding]; other site 279010005269 G4 box; other site 279010005270 G5 box; other site 279010005271 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 279010005272 G1 box; other site 279010005273 G1 box; other site 279010005274 GTP/Mg2+ binding site [chemical binding]; other site 279010005275 Switch I region; other site 279010005276 G2 box; other site 279010005277 G2 box; other site 279010005278 G3 box; other site 279010005279 G3 box; other site 279010005280 Switch II region; other site 279010005281 Switch II region; other site 279010005282 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 279010005283 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010005284 active site 279010005285 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 279010005286 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 279010005287 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 279010005288 CoA-ligase; Region: Ligase_CoA; pfam00549 279010005289 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 279010005290 CoA binding domain; Region: CoA_binding; pfam02629 279010005291 CoA-ligase; Region: Ligase_CoA; pfam00549 279010005292 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 279010005293 DNA protecting protein DprA; Region: dprA; TIGR00732 279010005294 DNA topoisomerase I; Validated; Region: PRK05582 279010005295 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 279010005296 active site 279010005297 interdomain interaction site; other site 279010005298 putative metal-binding site [ion binding]; other site 279010005299 nucleotide binding site [chemical binding]; other site 279010005300 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 279010005301 domain I; other site 279010005302 DNA binding groove [nucleotide binding] 279010005303 phosphate binding site [ion binding]; other site 279010005304 domain II; other site 279010005305 domain III; other site 279010005306 nucleotide binding site [chemical binding]; other site 279010005307 catalytic site [active] 279010005308 domain IV; other site 279010005309 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 279010005310 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 279010005311 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 279010005312 Glucose inhibited division protein A; Region: GIDA; pfam01134 279010005313 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 279010005314 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 279010005315 active site 279010005316 Int/Topo IB signature motif; other site 279010005317 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 279010005318 active site 279010005319 HslU subunit interaction site [polypeptide binding]; other site 279010005320 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 279010005321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010005322 Walker A motif; other site 279010005323 ATP binding site [chemical binding]; other site 279010005324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 279010005325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 279010005326 transcriptional repressor CodY; Validated; Region: PRK04158 279010005327 CodY GAF-like domain; Region: CodY; pfam06018 279010005328 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 279010005329 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 279010005330 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 279010005331 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 279010005332 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 279010005333 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 279010005334 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 279010005335 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 279010005336 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 279010005337 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 279010005338 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 279010005339 MgtE intracellular N domain; Region: MgtE_N; cl15244 279010005340 FliG C-terminal domain; Region: FliG_C; pfam01706 279010005341 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 279010005342 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 279010005343 Flagellar assembly protein FliH; Region: FliH; pfam02108 279010005344 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 279010005345 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 279010005346 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 279010005347 Walker A motif/ATP binding site; other site 279010005348 Walker B motif; other site 279010005349 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 279010005350 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 279010005351 Uncharacterized conserved protein [Function unknown]; Region: COG3334 279010005352 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 279010005353 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 279010005354 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 279010005355 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 279010005356 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 279010005357 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 279010005358 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 279010005359 Flagellar protein (FlbD); Region: FlbD; pfam06289 279010005360 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 279010005361 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 279010005362 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 279010005363 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 279010005364 flagellar motor switch protein; Validated; Region: PRK08119 279010005365 CheC-like family; Region: CheC; pfam04509 279010005366 CheC-like family; Region: CheC; pfam04509 279010005367 flagellar motor switch protein FliN; Region: fliN; TIGR02480 279010005368 Response regulator receiver domain; Region: Response_reg; pfam00072 279010005369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010005370 active site 279010005371 phosphorylation site [posttranslational modification] 279010005372 intermolecular recognition site; other site 279010005373 dimerization interface [polypeptide binding]; other site 279010005374 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 279010005375 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 279010005376 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 279010005377 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 279010005378 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 279010005379 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 279010005380 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 279010005381 FHIPEP family; Region: FHIPEP; pfam00771 279010005382 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 279010005383 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 279010005384 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 279010005385 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 279010005386 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 279010005387 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 279010005388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010005389 active site 279010005390 phosphorylation site [posttranslational modification] 279010005391 intermolecular recognition site; other site 279010005392 dimerization interface [polypeptide binding]; other site 279010005393 CheB methylesterase; Region: CheB_methylest; pfam01339 279010005394 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 279010005395 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 279010005396 putative binding surface; other site 279010005397 active site 279010005398 P2 response regulator binding domain; Region: P2; pfam07194 279010005399 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 279010005400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010005401 ATP binding site [chemical binding]; other site 279010005402 Mg2+ binding site [ion binding]; other site 279010005403 G-X-G motif; other site 279010005404 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 279010005405 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 279010005406 putative CheA interaction surface; other site 279010005407 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 279010005408 CheC-like family; Region: CheC; pfam04509 279010005409 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 279010005410 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 279010005411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010005412 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010005413 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010005414 DNA binding residues [nucleotide binding] 279010005415 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 279010005416 rRNA interaction site [nucleotide binding]; other site 279010005417 S8 interaction site; other site 279010005418 putative laminin-1 binding site; other site 279010005419 elongation factor Ts; Provisional; Region: tsf; PRK09377 279010005420 UBA/TS-N domain; Region: UBA; pfam00627 279010005421 Elongation factor TS; Region: EF_TS; pfam00889 279010005422 Elongation factor TS; Region: EF_TS; pfam00889 279010005423 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 279010005424 putative nucleotide binding site [chemical binding]; other site 279010005425 uridine monophosphate binding site [chemical binding]; other site 279010005426 homohexameric interface [polypeptide binding]; other site 279010005427 ribosome recycling factor; Reviewed; Region: frr; PRK00083 279010005428 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 279010005429 hinge region; other site 279010005430 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 279010005431 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 279010005432 catalytic residue [active] 279010005433 putative FPP diphosphate binding site; other site 279010005434 putative FPP binding hydrophobic cleft; other site 279010005435 dimer interface [polypeptide binding]; other site 279010005436 putative IPP diphosphate binding site; other site 279010005437 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 279010005438 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 279010005439 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 279010005440 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 279010005441 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 279010005442 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 279010005443 RIP metalloprotease RseP; Region: TIGR00054 279010005444 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 279010005445 active site 279010005446 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 279010005447 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 279010005448 protein binding site [polypeptide binding]; other site 279010005449 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 279010005450 putative substrate binding region [chemical binding]; other site 279010005451 prolyl-tRNA synthetase; Provisional; Region: PRK09194 279010005452 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 279010005453 dimer interface [polypeptide binding]; other site 279010005454 motif 1; other site 279010005455 active site 279010005456 motif 2; other site 279010005457 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 279010005458 putative deacylase active site [active] 279010005459 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 279010005460 active site 279010005461 motif 3; other site 279010005462 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 279010005463 anticodon binding site; other site 279010005464 DNA polymerase III PolC; Validated; Region: polC; PRK00448 279010005465 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 279010005466 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 279010005467 generic binding surface II; other site 279010005468 generic binding surface I; other site 279010005469 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 279010005470 active site 279010005471 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 279010005472 active site 279010005473 catalytic site [active] 279010005474 substrate binding site [chemical binding]; other site 279010005475 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 279010005476 endoglucanase; Region: PLN02420 279010005477 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 279010005478 Cellulose binding domain; Region: CBM_3; smart01067 279010005479 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 279010005480 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 279010005481 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 279010005482 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 279010005483 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 279010005484 ribosome maturation protein RimP; Reviewed; Region: PRK00092 279010005485 Sm and related proteins; Region: Sm_like; cl00259 279010005486 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 279010005487 putative oligomer interface [polypeptide binding]; other site 279010005488 putative RNA binding site [nucleotide binding]; other site 279010005489 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 279010005490 NusA N-terminal domain; Region: NusA_N; pfam08529 279010005491 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 279010005492 RNA binding site [nucleotide binding]; other site 279010005493 homodimer interface [polypeptide binding]; other site 279010005494 NusA-like KH domain; Region: KH_5; pfam13184 279010005495 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 279010005496 G-X-X-G motif; other site 279010005497 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 279010005498 putative RNA binding cleft [nucleotide binding]; other site 279010005499 hypothetical protein; Provisional; Region: PRK07714 279010005500 translation initiation factor IF-2; Validated; Region: infB; PRK05306 279010005501 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 279010005502 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 279010005503 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 279010005504 G1 box; other site 279010005505 putative GEF interaction site [polypeptide binding]; other site 279010005506 GTP/Mg2+ binding site [chemical binding]; other site 279010005507 Switch I region; other site 279010005508 G2 box; other site 279010005509 G3 box; other site 279010005510 Switch II region; other site 279010005511 G4 box; other site 279010005512 G5 box; other site 279010005513 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 279010005514 Translation-initiation factor 2; Region: IF-2; pfam11987 279010005515 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 279010005516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 279010005517 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 279010005518 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 279010005519 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 279010005520 RNA binding site [nucleotide binding]; other site 279010005521 active site 279010005522 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 279010005523 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 279010005524 active site 279010005525 Riboflavin kinase; Region: Flavokinase; smart00904 279010005526 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 279010005527 16S/18S rRNA binding site [nucleotide binding]; other site 279010005528 S13e-L30e interaction site [polypeptide binding]; other site 279010005529 25S rRNA binding site [nucleotide binding]; other site 279010005530 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 279010005531 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 279010005532 RNase E interface [polypeptide binding]; other site 279010005533 trimer interface [polypeptide binding]; other site 279010005534 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 279010005535 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 279010005536 RNase E interface [polypeptide binding]; other site 279010005537 trimer interface [polypeptide binding]; other site 279010005538 active site 279010005539 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 279010005540 putative nucleic acid binding region [nucleotide binding]; other site 279010005541 G-X-X-G motif; other site 279010005542 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 279010005543 RNA binding site [nucleotide binding]; other site 279010005544 domain interface; other site 279010005545 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 279010005546 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 279010005547 NodB motif; other site 279010005548 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279010005549 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279010005550 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279010005551 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 279010005552 dipicolinic acid synthetase, A subunit; Region: spore_dpaA; TIGR02853 279010005553 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 279010005554 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 279010005555 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 279010005556 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 279010005557 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 279010005558 aspartate kinase I; Reviewed; Region: PRK08210 279010005559 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 279010005560 nucleotide binding site [chemical binding]; other site 279010005561 substrate binding site [chemical binding]; other site 279010005562 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 279010005563 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 279010005564 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 279010005565 dihydrodipicolinate synthase; Region: dapA; TIGR00674 279010005566 dimer interface [polypeptide binding]; other site 279010005567 active site 279010005568 catalytic residue [active] 279010005569 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 279010005570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010005571 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 279010005572 Clp protease; Region: CLP_protease; pfam00574 279010005573 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 279010005574 active site 279010005575 YlzJ-like protein; Region: YlzJ; pfam14035 279010005576 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 279010005577 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 279010005578 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 279010005579 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010005580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005581 DNA-binding site [nucleotide binding]; DNA binding site 279010005582 UTRA domain; Region: UTRA; pfam07702 279010005583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010005585 putative substrate translocation pore; other site 279010005586 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279010005587 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279010005588 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279010005589 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279010005590 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279010005591 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279010005592 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279010005593 classical (c) SDRs; Region: SDR_c; cd05233 279010005594 NAD(P) binding site [chemical binding]; other site 279010005595 active site 279010005596 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 279010005597 ACT domain; Region: ACT; pfam01842 279010005598 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 279010005599 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 279010005600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010005601 non-specific DNA binding site [nucleotide binding]; other site 279010005602 salt bridge; other site 279010005603 sequence-specific DNA binding site [nucleotide binding]; other site 279010005604 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 279010005605 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 279010005606 competence damage-inducible protein A; Provisional; Region: PRK00549 279010005607 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 279010005608 putative MPT binding site; other site 279010005609 Competence-damaged protein; Region: CinA; pfam02464 279010005610 recombinase A; Provisional; Region: recA; PRK09354 279010005611 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 279010005612 hexamer interface [polypeptide binding]; other site 279010005613 Walker A motif; other site 279010005614 ATP binding site [chemical binding]; other site 279010005615 Walker B motif; other site 279010005616 phosphodiesterase; Provisional; Region: PRK12704 279010005617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010005618 Zn2+ binding site [ion binding]; other site 279010005619 Mg2+ binding site [ion binding]; other site 279010005620 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 279010005621 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010005622 putative active site [active] 279010005623 metal binding site [ion binding]; metal-binding site 279010005624 homodimer binding site [polypeptide binding]; other site 279010005625 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 279010005626 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 279010005627 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 279010005628 active site 279010005629 dimer interface [polypeptide binding]; other site 279010005630 Threonine dehydrogenase; Region: TDH; cd05281 279010005631 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 279010005632 structural Zn binding site [ion binding]; other site 279010005633 catalytic Zn binding site [ion binding]; other site 279010005634 tetramer interface [polypeptide binding]; other site 279010005635 NADP binding site [chemical binding]; other site 279010005636 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 279010005637 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 279010005638 substrate-cofactor binding pocket; other site 279010005639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010005640 catalytic residue [active] 279010005641 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 279010005642 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 279010005643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010005644 FeS/SAM binding site; other site 279010005645 TRAM domain; Region: TRAM; cl01282 279010005646 Predicted membrane protein [Function unknown]; Region: COG4550 279010005647 Outer spore coat protein E (CotE); Region: CotE; pfam10628 279010005648 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 279010005649 MutS domain I; Region: MutS_I; pfam01624 279010005650 MutS domain II; Region: MutS_II; pfam05188 279010005651 MutS domain III; Region: MutS_III; pfam05192 279010005652 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 279010005653 Walker A/P-loop; other site 279010005654 ATP binding site [chemical binding]; other site 279010005655 Q-loop/lid; other site 279010005656 ABC transporter signature motif; other site 279010005657 Walker B; other site 279010005658 D-loop; other site 279010005659 H-loop/switch region; other site 279010005660 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 279010005661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010005662 ATP binding site [chemical binding]; other site 279010005663 Mg2+ binding site [ion binding]; other site 279010005664 G-X-G motif; other site 279010005665 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 279010005666 ATP binding site [chemical binding]; other site 279010005667 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 279010005668 Uncharacterized conserved protein [Function unknown]; Region: COG1359 279010005669 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010005670 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279010005671 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 279010005672 P-loop, Walker A motif; other site 279010005673 Base recognition motif; other site 279010005674 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 279010005675 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 279010005676 dimer interface [polypeptide binding]; other site 279010005677 [2Fe-2S] cluster binding site [ion binding]; other site 279010005678 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279010005679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010005680 Coenzyme A binding pocket [chemical binding]; other site 279010005681 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 279010005682 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 279010005683 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 279010005684 TrkA-C domain; Region: TrkA_C; pfam02080 279010005685 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 279010005686 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 279010005687 TAP-like protein; Region: Abhydrolase_4; pfam08386 279010005688 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 279010005689 Uncharacterized conserved protein [Function unknown]; Region: COG0398 279010005690 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279010005691 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279010005692 Beta-lactamase; Region: Beta-lactamase; pfam00144 279010005693 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 279010005694 glycosyltransferase, MGT family; Region: MGT; TIGR01426 279010005695 active site 279010005696 TDP-binding site; other site 279010005697 acceptor substrate-binding pocket; other site 279010005698 homodimer interface [polypeptide binding]; other site 279010005699 amino acid transporter; Region: 2A0306; TIGR00909 279010005700 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 279010005701 Coat F domain; Region: Coat_F; cl17715 279010005702 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 279010005703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010005704 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010005705 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 279010005706 active site 279010005707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010005709 SnoaL-like domain; Region: SnoaL_3; pfam13474 279010005710 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 279010005711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005712 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010005713 NAD(P) binding site [chemical binding]; other site 279010005714 active site 279010005715 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 279010005716 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010005717 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279010005718 YmaF family; Region: YmaF; pfam12788 279010005719 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 279010005720 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 279010005721 bacterial Hfq-like; Region: Hfq; cd01716 279010005722 hexamer interface [polypeptide binding]; other site 279010005723 Sm1 motif; other site 279010005724 RNA binding site [nucleotide binding]; other site 279010005725 Sm2 motif; other site 279010005726 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 279010005727 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 279010005728 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 279010005729 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 279010005730 Class I ribonucleotide reductase; Region: RNR_I; cd01679 279010005731 active site 279010005732 dimer interface [polypeptide binding]; other site 279010005733 catalytic residues [active] 279010005734 effector binding site; other site 279010005735 R2 peptide binding site; other site 279010005736 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 279010005737 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 279010005738 dimer interface [polypeptide binding]; other site 279010005739 putative radical transfer pathway; other site 279010005740 diiron center [ion binding]; other site 279010005741 tyrosyl radical; other site 279010005742 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 279010005743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010005744 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 279010005745 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 279010005746 trimerization site [polypeptide binding]; other site 279010005747 active site 279010005748 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010005749 metal binding site 2 [ion binding]; metal-binding site 279010005750 putative DNA binding helix; other site 279010005751 metal binding site 1 [ion binding]; metal-binding site 279010005752 dimer interface [polypeptide binding]; other site 279010005753 structural Zn2+ binding site [ion binding]; other site 279010005754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010005755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005756 DNA-binding site [nucleotide binding]; DNA binding site 279010005757 FCD domain; Region: FCD; pfam07729 279010005758 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 279010005759 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010005760 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010005761 active site 279010005762 metal binding site [ion binding]; metal-binding site 279010005763 Sporulation related domain; Region: SPOR; pfam05036 279010005764 Protein of unknown function, DUF606; Region: DUF606; pfam04657 279010005765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 279010005766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010005768 OsmC-like protein; Region: OsmC; pfam02566 279010005769 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 279010005770 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 279010005771 Na binding site [ion binding]; other site 279010005772 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 279010005773 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 279010005774 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 279010005775 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 279010005776 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 279010005777 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 279010005778 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 279010005779 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 279010005780 stage V sporulation protein K; Region: spore_V_K; TIGR02881 279010005781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010005782 Walker A motif; other site 279010005783 ATP binding site [chemical binding]; other site 279010005784 Walker B motif; other site 279010005785 arginine finger; other site 279010005786 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 279010005787 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 279010005788 HflX GTPase family; Region: HflX; cd01878 279010005789 G1 box; other site 279010005790 GTP/Mg2+ binding site [chemical binding]; other site 279010005791 Switch I region; other site 279010005792 G2 box; other site 279010005793 G3 box; other site 279010005794 Switch II region; other site 279010005795 G4 box; other site 279010005796 G5 box; other site 279010005797 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 279010005798 Aluminium resistance protein; Region: Alum_res; pfam06838 279010005799 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 279010005800 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010005801 DNA binding residues [nucleotide binding] 279010005802 glutamine synthetase, type I; Region: GlnA; TIGR00653 279010005803 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 279010005804 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 279010005805 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 279010005806 nucleotide binding site/active site [active] 279010005807 HIT family signature motif; other site 279010005808 catalytic residue [active] 279010005809 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010005810 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 279010005811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010005812 S-adenosylmethionine binding site [chemical binding]; other site 279010005813 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279010005814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010005815 Coenzyme A binding pocket [chemical binding]; other site 279010005816 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 279010005817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010005819 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279010005820 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279010005821 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 279010005822 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010005823 Coenzyme A binding pocket [chemical binding]; other site 279010005824 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 279010005825 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279010005826 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010005827 catalytic residues [active] 279010005828 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 279010005829 dimanganese center [ion binding]; other site 279010005830 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 279010005831 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 279010005832 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010005833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010005834 Coenzyme A binding pocket [chemical binding]; other site 279010005835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010005836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010005838 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 279010005839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010005840 MarR family; Region: MarR; pfam01047 279010005841 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 279010005842 dimer interface [polypeptide binding]; other site 279010005843 FMN binding site [chemical binding]; other site 279010005844 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 279010005845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010005846 Zn binding site [ion binding]; other site 279010005847 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 279010005848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010005849 Zn binding site [ion binding]; other site 279010005850 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 279010005851 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 279010005852 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010005853 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 279010005854 thymidylate synthase; Reviewed; Region: thyA; PRK01827 279010005855 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 279010005856 dimerization interface [polypeptide binding]; other site 279010005857 active site 279010005858 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 279010005859 LexA repressor; Validated; Region: PRK00215 279010005860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010005861 putative DNA binding site [nucleotide binding]; other site 279010005862 putative Zn2+ binding site [ion binding]; other site 279010005863 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 279010005864 Catalytic site [active] 279010005865 cell division suppressor protein YneA; Provisional; Region: PRK14125 279010005866 LysM domain; Region: LysM; pfam01476 279010005867 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279010005868 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279010005869 catalytic residues [active] 279010005870 catalytic nucleophile [active] 279010005871 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 279010005872 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 279010005873 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 279010005874 TPP-binding site [chemical binding]; other site 279010005875 dimer interface [polypeptide binding]; other site 279010005876 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279010005877 PYR/PP interface [polypeptide binding]; other site 279010005878 dimer interface [polypeptide binding]; other site 279010005879 TPP binding site [chemical binding]; other site 279010005880 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010005881 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 279010005882 hypothetical protein; Provisional; Region: PRK01844 279010005883 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 279010005884 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 279010005885 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 279010005886 Response regulator receiver domain; Region: Response_reg; pfam00072 279010005887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010005888 active site 279010005889 phosphorylation site [posttranslational modification] 279010005890 intermolecular recognition site; other site 279010005891 dimerization interface [polypeptide binding]; other site 279010005892 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 279010005893 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 279010005894 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 279010005895 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 279010005896 putative dimer interface [polypeptide binding]; other site 279010005897 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 279010005898 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 279010005899 aconitate hydratase; Validated; Region: PRK09277 279010005900 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 279010005901 substrate binding site [chemical binding]; other site 279010005902 ligand binding site [chemical binding]; other site 279010005903 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 279010005904 substrate binding site [chemical binding]; other site 279010005905 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010005906 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279010005907 catalytic residues [active] 279010005908 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 279010005909 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 279010005910 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279010005911 active site 279010005912 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 279010005913 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 279010005914 Uncharacterized conserved protein [Function unknown]; Region: COG1434 279010005915 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 279010005916 putative active site [active] 279010005917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 279010005918 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 279010005919 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 279010005920 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 279010005921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010005922 ATP binding site [chemical binding]; other site 279010005923 Mg2+ binding site [ion binding]; other site 279010005924 G-X-G motif; other site 279010005925 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 279010005926 anchoring element; other site 279010005927 dimer interface [polypeptide binding]; other site 279010005928 ATP binding site [chemical binding]; other site 279010005929 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 279010005930 active site 279010005931 putative metal-binding site [ion binding]; other site 279010005932 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 279010005933 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 279010005934 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 279010005935 CAP-like domain; other site 279010005936 active site 279010005937 primary dimer interface [polypeptide binding]; other site 279010005938 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010005939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010005940 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010005941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005942 DNA-binding site [nucleotide binding]; DNA binding site 279010005943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010005944 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 279010005945 putative dimerization interface [polypeptide binding]; other site 279010005946 putative ligand binding site [chemical binding]; other site 279010005947 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 279010005948 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 279010005949 putative N- and C-terminal domain interface [polypeptide binding]; other site 279010005950 putative active site [active] 279010005951 MgATP binding site [chemical binding]; other site 279010005952 catalytic site [active] 279010005953 metal binding site [ion binding]; metal-binding site 279010005954 putative carbohydrate binding site [chemical binding]; other site 279010005955 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 279010005956 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 279010005957 intersubunit interface [polypeptide binding]; other site 279010005958 active site 279010005959 Zn2+ binding site [ion binding]; other site 279010005960 L-arabinose isomerase; Provisional; Region: PRK02929 279010005961 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 279010005962 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010005963 trimer interface [polypeptide binding]; other site 279010005964 substrate binding site [chemical binding]; other site 279010005965 Mn binding site [ion binding]; other site 279010005966 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279010005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005968 putative substrate translocation pore; other site 279010005969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005970 acetoin reductase; Validated; Region: PRK08643 279010005971 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 279010005972 NAD binding site [chemical binding]; other site 279010005973 homotetramer interface [polypeptide binding]; other site 279010005974 homodimer interface [polypeptide binding]; other site 279010005975 active site 279010005976 substrate binding site [chemical binding]; other site 279010005977 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010005978 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 279010005979 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 279010005980 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 279010005981 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 279010005982 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 279010005983 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 279010005984 [4Fe-4S] binding site [ion binding]; other site 279010005985 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010005986 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010005987 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010005988 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 279010005989 molybdopterin cofactor binding site; other site 279010005990 Uncharacterized conserved protein [Function unknown]; Region: COG2461 279010005991 Family of unknown function (DUF438); Region: DUF438; pfam04282 279010005992 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 279010005993 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 279010005994 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 279010005995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010005996 FeS/SAM binding site; other site 279010005997 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 279010005998 YwiC-like protein; Region: YwiC; pfam14256 279010005999 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279010006000 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 279010006001 ligand binding site [chemical binding]; other site 279010006002 flexible hinge region; other site 279010006003 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 279010006004 putative switch regulator; other site 279010006005 non-specific DNA interactions [nucleotide binding]; other site 279010006006 DNA binding site [nucleotide binding] 279010006007 sequence specific DNA binding site [nucleotide binding]; other site 279010006008 putative cAMP binding site [chemical binding]; other site 279010006009 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 279010006010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006011 putative substrate translocation pore; other site 279010006012 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 279010006013 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 279010006014 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279010006015 ligand binding site [chemical binding]; other site 279010006016 flexible hinge region; other site 279010006017 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 279010006018 putative switch regulator; other site 279010006019 non-specific DNA interactions [nucleotide binding]; other site 279010006020 DNA binding site [nucleotide binding] 279010006021 sequence specific DNA binding site [nucleotide binding]; other site 279010006022 putative cAMP binding site [chemical binding]; other site 279010006023 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 279010006024 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 279010006025 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 279010006026 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 279010006027 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 279010006028 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 279010006029 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 279010006030 Cellulose binding domain; Region: CBM_3; pfam00942 279010006031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010006032 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010006033 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 279010006034 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 279010006035 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279010006036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010006037 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 279010006038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006039 S-adenosylmethionine binding site [chemical binding]; other site 279010006040 Rrf2 family protein; Region: rrf2_super; TIGR00738 279010006041 Transcriptional regulator; Region: Rrf2; pfam02082 279010006042 Right handed beta helix region; Region: Beta_helix; pfam13229 279010006043 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 279010006044 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 279010006045 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 279010006046 putative NAD(P) binding site [chemical binding]; other site 279010006047 putative substrate binding site [chemical binding]; other site 279010006048 catalytic Zn binding site [ion binding]; other site 279010006049 structural Zn binding site [ion binding]; other site 279010006050 dimer interface [polypeptide binding]; other site 279010006051 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 279010006052 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010006053 DNA binding residues [nucleotide binding] 279010006054 putative dimer interface [polypeptide binding]; other site 279010006055 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279010006056 dimerization domain swap beta strand [polypeptide binding]; other site 279010006057 regulatory protein interface [polypeptide binding]; other site 279010006058 active site 279010006059 regulatory phosphorylation site [posttranslational modification]; other site 279010006060 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 279010006061 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 279010006062 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 279010006063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010006064 substrate binding site [chemical binding]; other site 279010006065 oxyanion hole (OAH) forming residues; other site 279010006066 trimer interface [polypeptide binding]; other site 279010006067 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 279010006068 enoyl-CoA hydratase; Provisional; Region: PRK07658 279010006069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010006070 substrate binding site [chemical binding]; other site 279010006071 oxyanion hole (OAH) forming residues; other site 279010006072 trimer interface [polypeptide binding]; other site 279010006073 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 279010006074 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 279010006075 tetrameric interface [polypeptide binding]; other site 279010006076 NAD binding site [chemical binding]; other site 279010006077 catalytic residues [active] 279010006078 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 279010006079 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 279010006080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 279010006081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010006082 active site 279010006083 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 279010006084 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 279010006085 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 279010006086 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279010006087 active site 279010006088 P-loop; other site 279010006089 phosphorylation site [posttranslational modification] 279010006090 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 279010006091 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010006092 active site 279010006093 phosphorylation site [posttranslational modification] 279010006094 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 279010006095 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010006096 HTH domain; Region: HTH_11; pfam08279 279010006097 Mga helix-turn-helix domain; Region: Mga; pfam05043 279010006098 PRD domain; Region: PRD; pfam00874 279010006099 PRD domain; Region: PRD; pfam00874 279010006100 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010006101 active site 279010006102 P-loop; other site 279010006103 phosphorylation site [posttranslational modification] 279010006104 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010006105 active site 279010006106 phosphorylation site [posttranslational modification] 279010006107 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 279010006108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010006109 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010006110 Walker A/P-loop; other site 279010006111 ATP binding site [chemical binding]; other site 279010006112 Q-loop/lid; other site 279010006113 ABC transporter signature motif; other site 279010006114 Walker B; other site 279010006115 D-loop; other site 279010006116 H-loop/switch region; other site 279010006117 Predicted transcriptional regulators [Transcription]; Region: COG1725 279010006118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010006119 DNA-binding site [nucleotide binding]; DNA binding site 279010006120 D-mannonate oxidoreductase; Provisional; Region: PRK08277 279010006121 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 279010006122 putative NAD(P) binding site [chemical binding]; other site 279010006123 active site 279010006124 mannonate dehydratase; Provisional; Region: PRK03906 279010006125 mannonate dehydratase; Region: uxuA; TIGR00695 279010006126 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 279010006127 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 279010006128 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 279010006129 putative active site [active] 279010006130 putative catalytic site [active] 279010006131 DctM-like transporters; Region: DctM; pfam06808 279010006132 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 279010006133 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 279010006134 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 279010006135 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 279010006136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010006137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010006138 DNA binding site [nucleotide binding] 279010006139 domain linker motif; other site 279010006140 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 279010006141 putative dimerization interface [polypeptide binding]; other site 279010006142 putative ligand binding site [chemical binding]; other site 279010006143 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 279010006144 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279010006145 active site 279010006146 arsenical pump membrane protein; Provisional; Region: PRK15445 279010006147 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 279010006148 transmembrane helices; other site 279010006149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010006150 putative DNA binding site [nucleotide binding]; other site 279010006151 dimerization interface [polypeptide binding]; other site 279010006152 putative Zn2+ binding site [ion binding]; other site 279010006153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 279010006154 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 279010006155 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 279010006156 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 279010006157 putative catalytic site [active] 279010006158 putative metal binding site [ion binding]; other site 279010006159 putative phosphate binding site [ion binding]; other site 279010006160 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 279010006161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 279010006162 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 279010006163 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 279010006164 DHH family; Region: DHH; pfam01368 279010006165 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 279010006166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010006167 FeS/SAM binding site; other site 279010006168 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 279010006169 Pyruvate formate lyase 1; Region: PFL1; cd01678 279010006170 coenzyme A binding site [chemical binding]; other site 279010006171 active site 279010006172 catalytic residues [active] 279010006173 glycine loop; other site 279010006174 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010006175 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 279010006176 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279010006177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010006178 Uncharacterized conserved protein [Function unknown]; Region: COG2427 279010006179 Helix-turn-helix domain; Region: HTH_17; cl17695 279010006180 acetyl-CoA synthetase; Provisional; Region: PRK00174 279010006181 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 279010006182 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 279010006183 acyl-activating enzyme (AAE) consensus motif; other site 279010006184 putative AMP binding site [chemical binding]; other site 279010006185 putative active site [active] 279010006186 putative CoA binding site [chemical binding]; other site 279010006187 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 279010006188 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 279010006189 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 279010006190 enoyl-CoA hydratase; Provisional; Region: PRK07657 279010006191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010006192 substrate binding site [chemical binding]; other site 279010006193 oxyanion hole (OAH) forming residues; other site 279010006194 trimer interface [polypeptide binding]; other site 279010006195 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 279010006196 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 279010006197 active site 279010006198 catalytic residues [active] 279010006199 metal binding site [ion binding]; metal-binding site 279010006200 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010006201 carboxyltransferase (CT) interaction site; other site 279010006202 biotinylation site [posttranslational modification]; other site 279010006203 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 279010006204 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010006205 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279010006206 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 279010006207 AMP-binding domain protein; Validated; Region: PRK08315 279010006208 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 279010006209 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 279010006210 acyl-activating enzyme (AAE) consensus motif; other site 279010006211 putative AMP binding site [chemical binding]; other site 279010006212 putative active site [active] 279010006213 putative CoA binding site [chemical binding]; other site 279010006214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010006215 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 279010006216 FAD binding site [chemical binding]; other site 279010006217 homotetramer interface [polypeptide binding]; other site 279010006218 substrate binding pocket [chemical binding]; other site 279010006219 catalytic base [active] 279010006220 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 279010006221 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010006222 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279010006223 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 279010006224 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 279010006225 putative catalytic cysteine [active] 279010006226 gamma-glutamyl kinase; Provisional; Region: PRK13402 279010006227 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 279010006228 nucleotide binding site [chemical binding]; other site 279010006229 homotetrameric interface [polypeptide binding]; other site 279010006230 putative phosphate binding site [ion binding]; other site 279010006231 putative allosteric binding site; other site 279010006232 PUA domain; Region: PUA; pfam01472 279010006233 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 279010006234 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 279010006235 Predicted membrane protein [Function unknown]; Region: COG2323 279010006236 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 279010006237 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 279010006238 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 279010006239 Active Sites [active] 279010006240 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 279010006241 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010006242 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010006243 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 279010006244 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 279010006245 active site pocket [active] 279010006246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010006248 putative substrate translocation pore; other site 279010006249 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279010006250 Ligand binding site; other site 279010006251 Putative Catalytic site; other site 279010006252 DXD motif; other site 279010006253 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 279010006254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279010006255 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 279010006256 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 279010006257 active site 279010006258 dimer interface [polypeptide binding]; other site 279010006259 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 279010006260 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 279010006261 active site 279010006262 FMN binding site [chemical binding]; other site 279010006263 substrate binding site [chemical binding]; other site 279010006264 3Fe-4S cluster binding site [ion binding]; other site 279010006265 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 279010006266 domain interface; other site 279010006267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010006268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010006269 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 279010006270 putative dimerization interface [polypeptide binding]; other site 279010006271 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 279010006272 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 279010006273 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 279010006274 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006275 MarR family; Region: MarR_2; pfam12802 279010006276 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010006277 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010006278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010006279 Walker A/P-loop; other site 279010006280 ATP binding site [chemical binding]; other site 279010006281 Q-loop/lid; other site 279010006282 ABC transporter signature motif; other site 279010006283 Walker B; other site 279010006284 D-loop; other site 279010006285 H-loop/switch region; other site 279010006286 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010006287 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010006288 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 279010006289 Walker A/P-loop; other site 279010006290 ATP binding site [chemical binding]; other site 279010006291 Q-loop/lid; other site 279010006292 ABC transporter signature motif; other site 279010006293 Walker B; other site 279010006294 D-loop; other site 279010006295 H-loop/switch region; other site 279010006296 Cytochrome P450; Region: p450; cl12078 279010006297 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279010006298 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 279010006299 classical (c) SDRs; Region: SDR_c; cd05233 279010006300 NAD(P) binding site [chemical binding]; other site 279010006301 active site 279010006302 phosphoenolpyruvate synthase; Validated; Region: PRK06241 279010006303 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279010006304 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 279010006305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010006307 putative substrate translocation pore; other site 279010006308 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 279010006309 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 279010006310 putative [4Fe-4S] binding site [ion binding]; other site 279010006311 putative molybdopterin cofactor binding site [chemical binding]; other site 279010006312 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 279010006313 putative molybdopterin cofactor binding site; other site 279010006314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006315 MarR family; Region: MarR; pfam01047 279010006316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006317 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010006318 Spore germination protein; Region: Spore_permease; pfam03845 279010006319 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 279010006320 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 279010006321 Spore germination protein; Region: Spore_permease; pfam03845 279010006322 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 279010006323 Spore germination protein; Region: Spore_permease; pfam03845 279010006324 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010006325 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010006326 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010006327 ABC transporter; Region: ABC_tran_2; pfam12848 279010006328 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010006329 Tar ligand binding domain homologue; Region: TarH; pfam02203 279010006330 Cache domain; Region: Cache_1; pfam02743 279010006331 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 279010006332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010006333 dimerization interface [polypeptide binding]; other site 279010006334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010006335 dimer interface [polypeptide binding]; other site 279010006336 putative CheW interface [polypeptide binding]; other site 279010006337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010006338 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 279010006339 dimer interface [polypeptide binding]; other site 279010006340 putative tRNA-binding site [nucleotide binding]; other site 279010006341 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 279010006342 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 279010006343 active site 279010006344 catalytic triad [active] 279010006345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010006346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010006347 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 279010006348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010006350 dimerization interface [polypeptide binding]; other site 279010006351 putative Zn2+ binding site [ion binding]; other site 279010006352 putative DNA binding site [nucleotide binding]; other site 279010006353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 279010006354 DinB superfamily; Region: DinB_2; pfam12867 279010006355 DinB family; Region: DinB; cl17821 279010006356 YndJ-like protein; Region: YndJ; pfam14158 279010006357 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 279010006358 DoxX-like family; Region: DoxX_3; pfam13781 279010006359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010006360 WHG domain; Region: WHG; pfam13305 279010006361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010006362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 279010006363 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 279010006364 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010006365 HTH domain; Region: HTH_11; pfam08279 279010006366 WYL domain; Region: WYL; pfam13280 279010006367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010006368 dimerization interface [polypeptide binding]; other site 279010006369 putative DNA binding site [nucleotide binding]; other site 279010006370 putative Zn2+ binding site [ion binding]; other site 279010006371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010006372 amino acid transporter; Region: 2A0306; TIGR00909 279010006373 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279010006374 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010006375 catalytic residue [active] 279010006376 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 279010006377 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 279010006378 NAD(P) binding site [chemical binding]; other site 279010006379 homodimer interface [polypeptide binding]; other site 279010006380 substrate binding site [chemical binding]; other site 279010006381 active site 279010006382 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 279010006383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010006384 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 279010006385 Predicted membrane protein [Function unknown]; Region: COG2322 279010006386 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010006387 putative transporter; Provisional; Region: PRK10484 279010006388 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 279010006389 Na binding site [ion binding]; other site 279010006390 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010006391 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010006392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 279010006393 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 279010006394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010006395 ATP binding site [chemical binding]; other site 279010006396 putative Mg++ binding site [ion binding]; other site 279010006397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010006398 nucleotide binding region [chemical binding]; other site 279010006399 ATP-binding site [chemical binding]; other site 279010006400 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 279010006401 HRDC domain; Region: HRDC; pfam00570 279010006402 Putative motility protein; Region: YjfB_motility; pfam14070 279010006403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 279010006404 Nuclease-related domain; Region: NERD; pfam08378 279010006405 Uncharacterized conserved protein [Function unknown]; Region: COG2427 279010006406 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 279010006407 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 279010006408 catalytic loop [active] 279010006409 iron binding site [ion binding]; other site 279010006410 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 279010006411 4Fe-4S binding domain; Region: Fer4_6; pfam12837 279010006412 4Fe-4S binding domain; Region: Fer4; pfam00037 279010006413 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 279010006414 [4Fe-4S] binding site [ion binding]; other site 279010006415 molybdopterin cofactor binding site; other site 279010006416 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 279010006417 molybdopterin cofactor binding site; other site 279010006418 Flagellar protein YcgR; Region: YcgR_2; pfam12945 279010006419 PilZ domain; Region: PilZ; pfam07238 279010006420 Mu-like prophage protein [General function prediction only]; Region: COG3941 279010006421 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 279010006422 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 279010006423 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 279010006424 hypothetical protein; Provisional; Region: PRK08204 279010006425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010006426 active site 279010006427 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 279010006428 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279010006429 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010006430 TAP-like protein; Region: Abhydrolase_4; pfam08386 279010006431 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 279010006432 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 279010006433 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 279010006434 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 279010006435 nudix motif; other site 279010006436 phosphoenolpyruvate synthase; Validated; Region: PRK06241 279010006437 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279010006438 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 279010006439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010006440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010006441 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279010006442 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 279010006443 DinB family; Region: DinB; cl17821 279010006444 DinB superfamily; Region: DinB_2; pfam12867 279010006445 azoreductase; Provisional; Region: PRK13556 279010006446 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 279010006447 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 279010006448 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 279010006449 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010006450 NAD(P) binding site [chemical binding]; other site 279010006451 catalytic residues [active] 279010006452 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010006453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006454 putative substrate translocation pore; other site 279010006455 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010006456 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010006457 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 279010006458 active site 279010006459 catalytic motif [active] 279010006460 Zn binding site [ion binding]; other site 279010006461 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 279010006462 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 279010006463 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 279010006464 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 279010006465 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 279010006466 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 279010006467 Na2 binding site [ion binding]; other site 279010006468 putative substrate binding site 1 [chemical binding]; other site 279010006469 Na binding site 1 [ion binding]; other site 279010006470 putative substrate binding site 2 [chemical binding]; other site 279010006471 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 279010006472 Sodium Bile acid symporter family; Region: SBF; pfam01758 279010006473 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 279010006474 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010006475 E3 interaction surface; other site 279010006476 lipoyl attachment site [posttranslational modification]; other site 279010006477 e3 binding domain; Region: E3_binding; pfam02817 279010006478 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279010006479 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 279010006480 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 279010006481 TPP-binding site [chemical binding]; other site 279010006482 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 279010006483 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 279010006484 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 279010006485 metal ion-dependent adhesion site (MIDAS); other site 279010006486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010006487 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010006488 Walker A motif; other site 279010006489 ATP binding site [chemical binding]; other site 279010006490 Walker B motif; other site 279010006491 arginine finger; other site 279010006492 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 279010006493 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 279010006494 E-class dimer interface [polypeptide binding]; other site 279010006495 P-class dimer interface [polypeptide binding]; other site 279010006496 active site 279010006497 Cu2+ binding site [ion binding]; other site 279010006498 Zn2+ binding site [ion binding]; other site 279010006499 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010006500 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010006501 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010006502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010006503 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010006504 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010006505 multidrug efflux protein; Reviewed; Region: PRK01766 279010006506 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 279010006507 cation binding site [ion binding]; other site 279010006508 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 279010006509 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 279010006510 Predicted permeases [General function prediction only]; Region: RarD; COG2962 279010006511 EamA-like transporter family; Region: EamA; pfam00892 279010006512 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 279010006513 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 279010006514 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 279010006515 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279010006516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006517 NAD(P) binding site [chemical binding]; other site 279010006518 active site 279010006519 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010006520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010006521 dimerization interface [polypeptide binding]; other site 279010006522 putative DNA binding site [nucleotide binding]; other site 279010006523 putative Zn2+ binding site [ion binding]; other site 279010006524 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 279010006525 dimer interface [polypeptide binding]; other site 279010006526 FMN binding site [chemical binding]; other site 279010006527 Predicted esterase [General function prediction only]; Region: COG0400 279010006528 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 279010006529 nucleophilic elbow; other site 279010006530 catalytic triad; other site 279010006531 TAP-like protein; Region: Abhydrolase_4; pfam08386 279010006532 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 279010006533 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 279010006534 Na binding site [ion binding]; other site 279010006535 Homeodomain-like domain; Region: HTH_23; pfam13384 279010006536 Transposase; Region: HTH_Tnp_1; cl17663 279010006537 putative transposase OrfB; Reviewed; Region: PHA02517 279010006538 HTH-like domain; Region: HTH_21; pfam13276 279010006539 Integrase core domain; Region: rve; pfam00665 279010006540 Integrase core domain; Region: rve_3; pfam13683 279010006541 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 279010006542 C-terminal peptidase (prc); Region: prc; TIGR00225 279010006543 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 279010006544 protein binding site [polypeptide binding]; other site 279010006545 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 279010006546 Catalytic dyad [active] 279010006547 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010006548 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279010006549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006550 S-adenosylmethionine binding site [chemical binding]; other site 279010006551 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 279010006552 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 279010006553 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 279010006554 Predicted permeases [General function prediction only]; Region: COG0701 279010006555 TIGR03943 family protein; Region: TIGR03943 279010006556 YodL-like; Region: YodL; pfam14191 279010006557 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 279010006558 active site 279010006559 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279010006560 YozD-like protein; Region: YozD; pfam14162 279010006561 hypothetical protein; Provisional; Region: PRK13672 279010006562 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 279010006563 toxin interface [polypeptide binding]; other site 279010006564 Zn binding site [ion binding]; other site 279010006565 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 279010006566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010006567 FeS/SAM binding site; other site 279010006568 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 279010006569 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 279010006570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006571 Coenzyme A binding pocket [chemical binding]; other site 279010006572 acetylornithine deacetylase; Validated; Region: PRK06915 279010006573 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 279010006574 metal binding site [ion binding]; metal-binding site 279010006575 dimer interface [polypeptide binding]; other site 279010006576 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 279010006577 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 279010006578 hypothetical protein; Provisional; Region: PRK06917 279010006579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010006580 inhibitor-cofactor binding pocket; inhibition site 279010006581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006582 catalytic residue [active] 279010006583 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010006584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006585 putative substrate translocation pore; other site 279010006586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006587 Coenzyme A binding pocket [chemical binding]; other site 279010006588 methionine sulfoxide reductase B; Provisional; Region: PRK00222 279010006589 SelR domain; Region: SelR; pfam01641 279010006590 methionine sulfoxide reductase A; Provisional; Region: PRK14054 279010006591 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006592 MarR family; Region: MarR; pfam01047 279010006593 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 279010006594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 279010006595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010006596 metal binding site [ion binding]; metal-binding site 279010006597 active site 279010006598 I-site; other site 279010006599 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 279010006600 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 279010006601 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 279010006602 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 279010006603 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 279010006604 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 279010006605 active site 279010006606 catalytic triad [active] 279010006607 oxyanion hole [active] 279010006608 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 279010006609 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 279010006610 Cu(I) binding site [ion binding]; other site 279010006611 EDD domain protein, DegV family; Region: DegV; TIGR00762 279010006612 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 279010006613 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 279010006614 threonine dehydratase; Validated; Region: PRK08639 279010006615 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 279010006616 tetramer interface [polypeptide binding]; other site 279010006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006618 catalytic residue [active] 279010006619 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 279010006620 putative Ile/Val binding site [chemical binding]; other site 279010006621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010006622 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010006623 Walker A motif; other site 279010006624 ATP binding site [chemical binding]; other site 279010006625 Walker B motif; other site 279010006626 arginine finger; other site 279010006627 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 279010006628 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 279010006629 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 279010006630 putative acyl-acceptor binding pocket; other site 279010006631 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 279010006632 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 279010006633 folate binding site [chemical binding]; other site 279010006634 NADP+ binding site [chemical binding]; other site 279010006635 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 279010006636 tetramer interfaces [polypeptide binding]; other site 279010006637 binuclear metal-binding site [ion binding]; other site 279010006638 YpjP-like protein; Region: YpjP; pfam14005 279010006639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006640 S-adenosylmethionine binding site [chemical binding]; other site 279010006641 Disulphide isomerase; Region: Disulph_isomer; pfam06491 279010006642 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 279010006643 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 279010006644 Virulence factor; Region: Virulence_fact; pfam13769 279010006645 HEAT repeats; Region: HEAT_2; pfam13646 279010006646 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 279010006647 HEAT repeats; Region: HEAT_2; pfam13646 279010006648 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 279010006649 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 279010006650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010006651 Zn2+ binding site [ion binding]; other site 279010006652 Mg2+ binding site [ion binding]; other site 279010006653 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 279010006654 catalytic residues [active] 279010006655 dimer interface [polypeptide binding]; other site 279010006656 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 279010006657 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 279010006658 Potassium binding sites [ion binding]; other site 279010006659 Cesium cation binding sites [ion binding]; other site 279010006660 homoserine O-succinyltransferase; Provisional; Region: PRK05368 279010006661 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 279010006662 proposed active site lysine [active] 279010006663 conserved cys residue [active] 279010006664 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 279010006665 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 279010006666 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010006667 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 279010006668 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 279010006669 DNA-binding site [nucleotide binding]; DNA binding site 279010006670 RNA-binding motif; other site 279010006671 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 279010006672 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 279010006673 hypothetical protein; Validated; Region: PRK07708 279010006674 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 279010006675 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010006676 active site 279010006677 conserved hypothetical integral membrane protein; Region: TIGR00697 279010006678 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 279010006679 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010006680 active site 279010006681 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 279010006682 5'-3' exonuclease; Region: 53EXOc; smart00475 279010006683 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 279010006684 active site 279010006685 metal binding site 1 [ion binding]; metal-binding site 279010006686 putative 5' ssDNA interaction site; other site 279010006687 metal binding site 3; metal-binding site 279010006688 metal binding site 2 [ion binding]; metal-binding site 279010006689 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 279010006690 putative DNA binding site [nucleotide binding]; other site 279010006691 putative metal binding site [ion binding]; other site 279010006692 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 279010006693 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 279010006694 Dynamin family; Region: Dynamin_N; pfam00350 279010006695 G1 box; other site 279010006696 GTP/Mg2+ binding site [chemical binding]; other site 279010006697 G2 box; other site 279010006698 Switch I region; other site 279010006699 G3 box; other site 279010006700 Switch II region; other site 279010006701 G4 box; other site 279010006702 G5 box; other site 279010006703 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 279010006704 G2 box; other site 279010006705 Switch I region; other site 279010006706 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 279010006707 G2 box; other site 279010006708 G3 box; other site 279010006709 Switch II region; other site 279010006710 GTP/Mg2+ binding site [chemical binding]; other site 279010006711 G4 box; other site 279010006712 G5 box; other site 279010006713 Phospholipid methyltransferase; Region: PEMT; cl17370 279010006714 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 279010006715 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 279010006716 malonyl-CoA binding site [chemical binding]; other site 279010006717 dimer interface [polypeptide binding]; other site 279010006718 active site 279010006719 product binding site; other site 279010006720 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010006721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006722 Coenzyme A binding pocket [chemical binding]; other site 279010006723 xanthine permease; Region: pbuX; TIGR03173 279010006724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010006725 active site 279010006726 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 279010006727 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 279010006728 active site 279010006729 Zn binding site [ion binding]; other site 279010006730 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 279010006731 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 279010006732 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 279010006733 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 279010006734 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 279010006735 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 279010006736 cell division protein GpsB; Provisional; Region: PRK14127 279010006737 DivIVA domain; Region: DivI1A_domain; TIGR03544 279010006738 hypothetical protein; Provisional; Region: PRK13660 279010006739 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 279010006740 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 279010006741 RNase_H superfamily; Region: RNase_H_2; pfam13482 279010006742 active site 279010006743 substrate binding site [chemical binding]; other site 279010006744 catalytic site [active] 279010006745 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 279010006746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010006747 ATP binding site [chemical binding]; other site 279010006748 putative Mg++ binding site [ion binding]; other site 279010006749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010006750 nucleotide binding region [chemical binding]; other site 279010006751 ATP-binding site [chemical binding]; other site 279010006752 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 279010006753 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 279010006754 HPr interaction site; other site 279010006755 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010006756 active site 279010006757 phosphorylation site [posttranslational modification] 279010006758 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 279010006759 YppG-like protein; Region: YppG; pfam14179 279010006760 YppF-like protein; Region: YppF; pfam14178 279010006761 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 279010006762 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 279010006763 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 279010006764 Transglycosylase; Region: Transgly; pfam00912 279010006765 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010006766 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010006767 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010006768 Interdomain contacts; other site 279010006769 Cytokine receptor motif; other site 279010006770 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 279010006771 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279010006772 minor groove reading motif; other site 279010006773 helix-hairpin-helix signature motif; other site 279010006774 substrate binding pocket [chemical binding]; other site 279010006775 active site 279010006776 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 279010006777 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 279010006778 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 279010006779 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 279010006780 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 279010006781 putative dimer interface [polypeptide binding]; other site 279010006782 putative anticodon binding site; other site 279010006783 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 279010006784 homodimer interface [polypeptide binding]; other site 279010006785 motif 1; other site 279010006786 motif 2; other site 279010006787 active site 279010006788 motif 3; other site 279010006789 aspartate aminotransferase; Provisional; Region: PRK05764 279010006790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010006791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006792 homodimer interface [polypeptide binding]; other site 279010006793 catalytic residue [active] 279010006794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 279010006795 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 279010006796 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 279010006797 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 279010006798 active site 279010006799 catalytic site [active] 279010006800 substrate binding site [chemical binding]; other site 279010006801 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 279010006802 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 279010006803 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 279010006804 tetramerization interface [polypeptide binding]; other site 279010006805 active site 279010006806 pantoate--beta-alanine ligase; Region: panC; TIGR00018 279010006807 Pantoate-beta-alanine ligase; Region: PanC; cd00560 279010006808 active site 279010006809 ATP-binding site [chemical binding]; other site 279010006810 pantoate-binding site; other site 279010006811 HXXH motif; other site 279010006812 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 279010006813 oligomerization interface [polypeptide binding]; other site 279010006814 active site 279010006815 metal binding site [ion binding]; metal-binding site 279010006816 Biotin operon repressor [Transcription]; Region: BirA; COG1654 279010006817 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 279010006818 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 279010006819 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 279010006820 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 279010006821 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 279010006822 active site 279010006823 NTP binding site [chemical binding]; other site 279010006824 metal binding triad [ion binding]; metal-binding site 279010006825 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 279010006826 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 279010006827 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 279010006828 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 279010006829 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 279010006830 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 279010006831 active site 279010006832 dimer interfaces [polypeptide binding]; other site 279010006833 catalytic residues [active] 279010006834 dihydrodipicolinate reductase; Provisional; Region: PRK00048 279010006835 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 279010006836 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 279010006837 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 279010006838 homodimer interface [polypeptide binding]; other site 279010006839 metal binding site [ion binding]; metal-binding site 279010006840 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010006841 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010006842 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010006843 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010006844 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 279010006845 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 279010006846 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 279010006847 Qo binding site; other site 279010006848 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 279010006849 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 279010006850 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 279010006851 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 279010006852 interchain domain interface [polypeptide binding]; other site 279010006853 intrachain domain interface; other site 279010006854 heme bH binding site [chemical binding]; other site 279010006855 Qi binding site; other site 279010006856 heme bL binding site [chemical binding]; other site 279010006857 Qo binding site; other site 279010006858 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 279010006859 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 279010006860 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 279010006861 iron-sulfur cluster [ion binding]; other site 279010006862 [2Fe-2S] cluster binding site [ion binding]; other site 279010006863 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 279010006864 hypothetical protein; Provisional; Region: PRK03636 279010006865 UPF0302 domain; Region: UPF0302; pfam08864 279010006866 IDEAL domain; Region: IDEAL; pfam08858 279010006867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006868 TPR motif; other site 279010006869 binding surface 279010006870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006871 binding surface 279010006872 TPR motif; other site 279010006873 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010006874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006875 binding surface 279010006876 TPR motif; other site 279010006877 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 279010006878 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 279010006879 hinge; other site 279010006880 active site 279010006881 prephenate dehydrogenase; Validated; Region: PRK06545 279010006882 prephenate dehydrogenase; Validated; Region: PRK08507 279010006883 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 279010006884 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 279010006885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010006886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006887 homodimer interface [polypeptide binding]; other site 279010006888 catalytic residue [active] 279010006889 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 279010006890 substrate binding site [chemical binding]; other site 279010006891 active site 279010006892 catalytic residues [active] 279010006893 heterodimer interface [polypeptide binding]; other site 279010006894 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 279010006895 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 279010006896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006897 catalytic residue [active] 279010006898 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 279010006899 active site 279010006900 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 279010006901 active site 279010006902 ribulose/triose binding site [chemical binding]; other site 279010006903 phosphate binding site [ion binding]; other site 279010006904 substrate (anthranilate) binding pocket [chemical binding]; other site 279010006905 product (indole) binding pocket [chemical binding]; other site 279010006906 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 279010006907 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279010006908 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010006909 anthranilate synthase component I; Provisional; Region: PRK13569 279010006910 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 279010006911 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 279010006912 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 279010006913 homotrimer interaction site [polypeptide binding]; other site 279010006914 active site 279010006915 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 279010006916 active site 279010006917 dimer interface [polypeptide binding]; other site 279010006918 metal binding site [ion binding]; metal-binding site 279010006919 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 279010006920 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 279010006921 Tetramer interface [polypeptide binding]; other site 279010006922 active site 279010006923 FMN-binding site [chemical binding]; other site 279010006924 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 279010006925 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 279010006926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006927 S-adenosylmethionine binding site [chemical binding]; other site 279010006928 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 279010006929 active site 279010006930 multimer interface [polypeptide binding]; other site 279010006931 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 279010006932 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 279010006933 substrate binding pocket [chemical binding]; other site 279010006934 chain length determination region; other site 279010006935 substrate-Mg2+ binding site; other site 279010006936 catalytic residues [active] 279010006937 aspartate-rich region 1; other site 279010006938 active site lid residues [active] 279010006939 aspartate-rich region 2; other site 279010006940 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 279010006941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006942 S-adenosylmethionine binding site [chemical binding]; other site 279010006943 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 279010006944 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 279010006945 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 279010006946 homodecamer interface [polypeptide binding]; other site 279010006947 GTP cyclohydrolase I; Provisional; Region: PLN03044 279010006948 active site 279010006949 putative catalytic site residues [active] 279010006950 zinc binding site [ion binding]; other site 279010006951 GTP-CH-I/GFRP interaction surface; other site 279010006952 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 279010006953 IHF dimer interface [polypeptide binding]; other site 279010006954 IHF - DNA interface [nucleotide binding]; other site 279010006955 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 279010006956 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 279010006957 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 279010006958 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 279010006959 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 279010006960 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 279010006961 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 279010006962 GTP-binding protein Der; Reviewed; Region: PRK00093 279010006963 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 279010006964 G1 box; other site 279010006965 GTP/Mg2+ binding site [chemical binding]; other site 279010006966 Switch I region; other site 279010006967 G2 box; other site 279010006968 Switch II region; other site 279010006969 G3 box; other site 279010006970 G4 box; other site 279010006971 G5 box; other site 279010006972 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 279010006973 G1 box; other site 279010006974 GTP/Mg2+ binding site [chemical binding]; other site 279010006975 Switch I region; other site 279010006976 G2 box; other site 279010006977 G3 box; other site 279010006978 Switch II region; other site 279010006979 G4 box; other site 279010006980 G5 box; other site 279010006981 YIEGIA protein; Region: YIEGIA; pfam14045 279010006982 YpzI-like protein; Region: YpzI; pfam14140 279010006983 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 279010006984 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 279010006985 homotetramer interface [polypeptide binding]; other site 279010006986 FMN binding site [chemical binding]; other site 279010006987 homodimer contacts [polypeptide binding]; other site 279010006988 putative active site [active] 279010006989 putative substrate binding site [chemical binding]; other site 279010006990 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 279010006991 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 279010006992 RNA binding site [nucleotide binding]; other site 279010006993 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 279010006994 RNA binding site [nucleotide binding]; other site 279010006995 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 279010006996 RNA binding site [nucleotide binding]; other site 279010006997 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 279010006998 RNA binding site [nucleotide binding]; other site 279010006999 cytidylate kinase; Provisional; Region: cmk; PRK00023 279010007000 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 279010007001 CMP-binding site; other site 279010007002 The sites determining sugar specificity; other site 279010007003 germination protein YpeB; Region: spore_YpeB; TIGR02889 279010007004 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010007005 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 279010007006 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 279010007007 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 279010007008 active site 279010007009 homotetramer interface [polypeptide binding]; other site 279010007010 homodimer interface [polypeptide binding]; other site 279010007011 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 279010007012 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 279010007013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010007014 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 279010007015 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279010007016 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 279010007017 NAD(P) binding site [chemical binding]; other site 279010007018 adaptor protein; Provisional; Region: PRK02899 279010007019 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 279010007020 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010007021 putative active site [active] 279010007022 putative metal binding site [ion binding]; other site 279010007023 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 279010007024 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010007025 CAAX protease self-immunity; Region: Abi; pfam02517 279010007026 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 279010007027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010007028 ATP binding site [chemical binding]; other site 279010007029 putative Mg++ binding site [ion binding]; other site 279010007030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010007031 nucleotide binding region [chemical binding]; other site 279010007032 ATP-binding site [chemical binding]; other site 279010007033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 279010007034 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 279010007035 Predicted membrane protein [Function unknown]; Region: COG3601 279010007036 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 279010007037 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 279010007038 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 279010007039 ligand binding site [chemical binding]; other site 279010007040 NAD binding site [chemical binding]; other site 279010007041 dimerization interface [polypeptide binding]; other site 279010007042 catalytic site [active] 279010007043 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 279010007044 putative L-serine binding site [chemical binding]; other site 279010007045 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279010007046 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010007047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010007048 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 279010007049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010007050 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 279010007051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010007052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010007053 DNA binding residues [nucleotide binding] 279010007054 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279010007055 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279010007056 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 279010007057 NodB motif; other site 279010007058 active site 279010007059 catalytic site [active] 279010007060 Zn binding site [ion binding]; other site 279010007061 FOG: WD40 repeat [General function prediction only]; Region: COG2319 279010007062 Rogdi leucine zipper containing protein; Region: Rogdi_lz; pfam10259 279010007063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010007064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010007065 dimerization interface [polypeptide binding]; other site 279010007066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010007067 dimer interface [polypeptide binding]; other site 279010007068 phosphorylation site [posttranslational modification] 279010007069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010007070 ATP binding site [chemical binding]; other site 279010007071 Mg2+ binding site [ion binding]; other site 279010007072 G-X-G motif; other site 279010007073 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010007074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010007075 active site 279010007076 phosphorylation site [posttranslational modification] 279010007077 intermolecular recognition site; other site 279010007078 dimerization interface [polypeptide binding]; other site 279010007079 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010007080 DNA binding site [nucleotide binding] 279010007081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 279010007082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010007083 dimerization interface [polypeptide binding]; other site 279010007084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010007085 putative active site [active] 279010007086 heme pocket [chemical binding]; other site 279010007087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010007088 dimer interface [polypeptide binding]; other site 279010007089 phosphorylation site [posttranslational modification] 279010007090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010007091 ATP binding site [chemical binding]; other site 279010007092 Mg2+ binding site [ion binding]; other site 279010007093 G-X-G motif; other site 279010007094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010007095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010007096 active site 279010007097 phosphorylation site [posttranslational modification] 279010007098 intermolecular recognition site; other site 279010007099 dimerization interface [polypeptide binding]; other site 279010007100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010007101 DNA binding site [nucleotide binding] 279010007102 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 279010007103 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 279010007104 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 279010007105 ResB-like family; Region: ResB; pfam05140 279010007106 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010007107 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279010007108 catalytic residues [active] 279010007109 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 279010007110 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010007111 RNA binding surface [nucleotide binding]; other site 279010007112 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 279010007113 active site 279010007114 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 279010007115 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 279010007116 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 279010007117 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 279010007118 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 279010007119 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 279010007120 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 279010007121 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 279010007122 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 279010007123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010007124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010007125 Coenzyme A binding pocket [chemical binding]; other site 279010007126 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 279010007127 homopentamer interface [polypeptide binding]; other site 279010007128 active site 279010007129 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 279010007130 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 279010007131 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 279010007132 dimerization interface [polypeptide binding]; other site 279010007133 active site 279010007134 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 279010007135 Lumazine binding domain; Region: Lum_binding; pfam00677 279010007136 Lumazine binding domain; Region: Lum_binding; pfam00677 279010007137 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 279010007138 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 279010007139 catalytic motif [active] 279010007140 Zn binding site [ion binding]; other site 279010007141 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 279010007142 AAA domain; Region: AAA_33; pfam13671 279010007143 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010007144 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 279010007145 active site 279010007146 metal binding site [ion binding]; metal-binding site 279010007147 RNA ligase; Region: RNA_lig_T4_1; pfam09511 279010007148 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 279010007149 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 279010007150 putative dimer interface [polypeptide binding]; other site 279010007151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010007152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010007153 TPR motif; other site 279010007154 binding surface 279010007155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010007156 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 279010007157 active site 279010007158 Predicted secreted protein [Function unknown]; Region: COG4086 279010007159 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 279010007160 Homeodomain-like domain; Region: HTH_23; pfam13384 279010007161 Transposase; Region: HTH_Tnp_1; cl17663 279010007162 putative transposase OrfB; Reviewed; Region: PHA02517 279010007163 HTH-like domain; Region: HTH_21; pfam13276 279010007164 Integrase core domain; Region: rve; pfam00665 279010007165 Integrase core domain; Region: rve_3; pfam13683 279010007166 Protein of unknown function (DUF867); Region: DUF867; pfam05908 279010007167 diaminopimelate decarboxylase; Region: lysA; TIGR01048 279010007168 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 279010007169 active site 279010007170 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010007171 substrate binding site [chemical binding]; other site 279010007172 catalytic residues [active] 279010007173 dimer interface [polypeptide binding]; other site 279010007174 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010007175 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 279010007176 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 279010007177 stage V sporulation protein AD; Validated; Region: PRK08304 279010007178 stage V sporulation protein AD; Provisional; Region: PRK12404 279010007179 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 279010007180 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 279010007181 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 279010007182 sporulation sigma factor SigF; Validated; Region: PRK05572 279010007183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010007184 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010007185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010007186 DNA binding residues [nucleotide binding] 279010007187 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279010007188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010007189 ATP binding site [chemical binding]; other site 279010007190 Mg2+ binding site [ion binding]; other site 279010007191 G-X-G motif; other site 279010007192 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 279010007193 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 279010007194 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 279010007195 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 279010007196 purine nucleoside phosphorylase; Provisional; Region: PRK08202 279010007197 phosphopentomutase; Provisional; Region: PRK05362 279010007198 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 279010007199 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 279010007200 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 279010007201 active site 279010007202 Int/Topo IB signature motif; other site 279010007203 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 279010007204 ferric uptake regulator; Provisional; Region: fur; PRK09462 279010007205 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010007206 metal binding site 2 [ion binding]; metal-binding site 279010007207 putative DNA binding helix; other site 279010007208 metal binding site 1 [ion binding]; metal-binding site 279010007209 dimer interface [polypeptide binding]; other site 279010007210 structural Zn2+ binding site [ion binding]; other site 279010007211 stage II sporulation protein M; Region: spo_II_M; TIGR02831 279010007212 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 279010007213 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010007214 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010007215 active site 279010007216 P-loop; other site 279010007217 phosphorylation site [posttranslational modification] 279010007218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010007219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010007220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010007221 Coenzyme A binding pocket [chemical binding]; other site 279010007222 TIGR00375 family protein; Region: TIGR00375 279010007223 PHP-associated; Region: PHP_C; pfam13263 279010007224 Transcription elongation factor Spt4; Region: Spt4; cl12033 279010007225 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 279010007226 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 279010007227 dimer interface [polypeptide binding]; other site 279010007228 ADP-ribose binding site [chemical binding]; other site 279010007229 active site 279010007230 nudix motif; other site 279010007231 metal binding site [ion binding]; metal-binding site 279010007232 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 279010007233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010007234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010007235 DoxX-like family; Region: DoxX_2; pfam13564 279010007236 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010007237 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010007238 active site 279010007239 catalytic tetrad [active] 279010007240 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279010007241 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 279010007242 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010007243 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 279010007244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 279010007245 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 279010007246 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279010007247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010007248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010007249 Coenzyme A binding pocket [chemical binding]; other site 279010007250 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 279010007251 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 279010007252 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 279010007253 Lipase (class 2); Region: Lipase_2; pfam01674 279010007254 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 279010007255 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279010007256 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010007257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007258 dimer interface [polypeptide binding]; other site 279010007259 conserved gate region; other site 279010007260 putative PBP binding loops; other site 279010007261 ABC-ATPase subunit interface; other site 279010007262 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 279010007263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007264 dimer interface [polypeptide binding]; other site 279010007265 conserved gate region; other site 279010007266 putative PBP binding loops; other site 279010007267 ABC-ATPase subunit interface; other site 279010007268 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 279010007269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010007270 Walker A/P-loop; other site 279010007271 ATP binding site [chemical binding]; other site 279010007272 Q-loop/lid; other site 279010007273 ABC transporter signature motif; other site 279010007274 Walker B; other site 279010007275 D-loop; other site 279010007276 H-loop/switch region; other site 279010007277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010007278 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 279010007279 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010007280 Walker A/P-loop; other site 279010007281 ATP binding site [chemical binding]; other site 279010007282 Q-loop/lid; other site 279010007283 ABC transporter signature motif; other site 279010007284 Walker B; other site 279010007285 D-loop; other site 279010007286 H-loop/switch region; other site 279010007287 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 279010007288 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 279010007289 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 279010007290 YolD-like protein; Region: YolD; pfam08863 279010007291 DNA polymerase IV; Reviewed; Region: PRK03103 279010007292 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 279010007293 active site 279010007294 DNA binding site [nucleotide binding] 279010007295 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 279010007296 YqzH-like protein; Region: YqzH; pfam14164 279010007297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010007299 putative substrate translocation pore; other site 279010007300 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 279010007301 putative dimer interface [polypeptide binding]; other site 279010007302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010007303 ligand binding site [chemical binding]; other site 279010007304 Zn binding site [ion binding]; other site 279010007305 pantothenate kinase; Provisional; Region: PRK05439 279010007306 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 279010007307 ATP-binding site [chemical binding]; other site 279010007308 CoA-binding site [chemical binding]; other site 279010007309 Mg2+-binding site [ion binding]; other site 279010007310 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279010007311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010007312 Walker A/P-loop; other site 279010007313 ATP binding site [chemical binding]; other site 279010007314 Q-loop/lid; other site 279010007315 ABC transporter signature motif; other site 279010007316 Walker B; other site 279010007317 D-loop; other site 279010007318 H-loop/switch region; other site 279010007319 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 279010007320 Protein of unknown function (DUF867); Region: DUF867; pfam05908 279010007321 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 279010007322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007323 NAD(P) binding site [chemical binding]; other site 279010007324 active site 279010007325 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 279010007326 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 279010007327 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 279010007328 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 279010007329 putative metal binding site [ion binding]; other site 279010007330 putative dimer interface [polypeptide binding]; other site 279010007331 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 279010007332 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 279010007333 active site 279010007334 FMN binding site [chemical binding]; other site 279010007335 substrate binding site [chemical binding]; other site 279010007336 homotetramer interface [polypeptide binding]; other site 279010007337 catalytic residue [active] 279010007338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010007339 Serine hydrolase; Region: Ser_hydrolase; cl17834 279010007340 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 279010007341 ribonuclease Z; Region: RNase_Z; TIGR02651 279010007342 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 279010007343 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 279010007344 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 279010007345 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 279010007346 DctM-like transporters; Region: DctM; pfam06808 279010007347 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 279010007348 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 279010007349 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 279010007350 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010007351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010007352 DNA-binding site [nucleotide binding]; DNA binding site 279010007353 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 279010007354 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 279010007355 beta-galactosidase; Region: BGL; TIGR03356 279010007356 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 279010007357 active site 279010007358 methionine cluster; other site 279010007359 phosphorylation site [posttranslational modification] 279010007360 metal binding site [ion binding]; metal-binding site 279010007361 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010007362 active site 279010007363 P-loop; other site 279010007364 phosphorylation site [posttranslational modification] 279010007365 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 279010007366 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 279010007367 dimer interface [polypeptide binding]; other site 279010007368 active site 279010007369 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 279010007370 glucose-1-dehydrogenase; Provisional; Region: PRK08936 279010007371 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 279010007372 NAD binding site [chemical binding]; other site 279010007373 homodimer interface [polypeptide binding]; other site 279010007374 active site 279010007375 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 279010007376 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 279010007377 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 279010007378 DNA polymerase IV; Validated; Region: PRK01810 279010007379 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 279010007380 active site 279010007381 DNA binding site [nucleotide binding] 279010007382 OxaA-like protein precursor; Validated; Region: PRK01622 279010007383 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 279010007384 peptidase T-like protein; Region: PepT-like; TIGR01883 279010007385 metal binding site [ion binding]; metal-binding site 279010007386 putative dimer interface [polypeptide binding]; other site 279010007387 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 279010007388 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 279010007389 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 279010007390 Predicted membrane protein [Function unknown]; Region: COG4129 279010007391 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 279010007392 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 279010007393 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 279010007394 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 279010007395 Walker A/P-loop; other site 279010007396 ATP binding site [chemical binding]; other site 279010007397 Q-loop/lid; other site 279010007398 ABC transporter signature motif; other site 279010007399 Walker B; other site 279010007400 D-loop; other site 279010007401 H-loop/switch region; other site 279010007402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007403 dimer interface [polypeptide binding]; other site 279010007404 conserved gate region; other site 279010007405 putative PBP binding loops; other site 279010007406 ABC-ATPase subunit interface; other site 279010007407 Disulphide isomerase; Region: Disulph_isomer; pfam06491 279010007408 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 279010007409 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 279010007410 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279010007411 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010007412 E3 interaction surface; other site 279010007413 lipoyl attachment site [posttranslational modification]; other site 279010007414 e3 binding domain; Region: E3_binding; pfam02817 279010007415 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279010007416 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279010007417 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279010007418 alpha subunit interface [polypeptide binding]; other site 279010007419 TPP binding site [chemical binding]; other site 279010007420 heterodimer interface [polypeptide binding]; other site 279010007421 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010007422 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 279010007423 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279010007424 tetramer interface [polypeptide binding]; other site 279010007425 TPP-binding site [chemical binding]; other site 279010007426 heterodimer interface [polypeptide binding]; other site 279010007427 phosphorylation loop region [posttranslational modification] 279010007428 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 279010007429 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 279010007430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010007431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279010007432 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010007433 nucleotide binding site [chemical binding]; other site 279010007434 Acetokinase family; Region: Acetate_kinase; cl17229 279010007435 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 279010007436 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279010007437 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 279010007438 NAD binding site [chemical binding]; other site 279010007439 Phe binding site; other site 279010007440 phosphate butyryltransferase; Validated; Region: PRK07742 279010007441 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 279010007442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010007443 putative active site [active] 279010007444 heme pocket [chemical binding]; other site 279010007445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010007446 putative active site [active] 279010007447 heme pocket [chemical binding]; other site 279010007448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010007449 Walker A motif; other site 279010007450 ATP binding site [chemical binding]; other site 279010007451 Walker B motif; other site 279010007452 arginine finger; other site 279010007453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 279010007454 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 279010007455 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010007456 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 279010007457 active site 279010007458 catalytic site [active] 279010007459 metal binding site [ion binding]; metal-binding site 279010007460 dimer interface [polypeptide binding]; other site 279010007461 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010007462 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010007463 active site 279010007464 metal binding site [ion binding]; metal-binding site 279010007465 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 279010007466 active site 279010007467 substrate binding site [chemical binding]; other site 279010007468 trimer interface [polypeptide binding]; other site 279010007469 CoA binding site [chemical binding]; other site 279010007470 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 279010007471 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 279010007472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010007473 active site 279010007474 phosphorylation site [posttranslational modification] 279010007475 intermolecular recognition site; other site 279010007476 dimerization interface [polypeptide binding]; other site 279010007477 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 279010007478 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 279010007479 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 279010007480 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 279010007481 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 279010007482 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 279010007483 Walker A/P-loop; other site 279010007484 ATP binding site [chemical binding]; other site 279010007485 Q-loop/lid; other site 279010007486 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 279010007487 ABC transporter signature motif; other site 279010007488 Walker B; other site 279010007489 D-loop; other site 279010007490 H-loop/switch region; other site 279010007491 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 279010007492 arginine repressor; Provisional; Region: PRK04280 279010007493 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 279010007494 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 279010007495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010007496 RNA binding surface [nucleotide binding]; other site 279010007497 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 279010007498 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 279010007499 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 279010007500 TPP-binding site; other site 279010007501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279010007502 PYR/PP interface [polypeptide binding]; other site 279010007503 dimer interface [polypeptide binding]; other site 279010007504 TPP binding site [chemical binding]; other site 279010007505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010007506 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 279010007507 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 279010007508 substrate binding pocket [chemical binding]; other site 279010007509 chain length determination region; other site 279010007510 substrate-Mg2+ binding site; other site 279010007511 catalytic residues [active] 279010007512 aspartate-rich region 1; other site 279010007513 active site lid residues [active] 279010007514 aspartate-rich region 2; other site 279010007515 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 279010007516 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 279010007517 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 279010007518 generic binding surface II; other site 279010007519 generic binding surface I; other site 279010007520 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 279010007521 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 279010007522 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 279010007523 homodimer interface [polypeptide binding]; other site 279010007524 NADP binding site [chemical binding]; other site 279010007525 substrate binding site [chemical binding]; other site 279010007526 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 279010007527 putative RNA binding site [nucleotide binding]; other site 279010007528 Asp23 family; Region: Asp23; pfam03780 279010007529 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 279010007530 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010007531 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279010007532 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 279010007533 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 279010007534 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010007535 carboxyltransferase (CT) interaction site; other site 279010007536 biotinylation site [posttranslational modification]; other site 279010007537 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 279010007538 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 279010007539 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 279010007540 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 279010007541 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 279010007542 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 279010007543 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 279010007544 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 279010007545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 279010007546 Walker A/P-loop; other site 279010007547 ATP binding site [chemical binding]; other site 279010007548 Q-loop/lid; other site 279010007549 ABC transporter signature motif; other site 279010007550 Walker B; other site 279010007551 H-loop/switch region; other site 279010007552 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 279010007553 elongation factor P; Validated; Region: PRK00529 279010007554 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 279010007555 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 279010007556 RNA binding site [nucleotide binding]; other site 279010007557 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 279010007558 RNA binding site [nucleotide binding]; other site 279010007559 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 279010007560 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 279010007561 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 279010007562 active site 279010007563 Dehydroquinase class II; Region: DHquinase_II; pfam01220 279010007564 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 279010007565 trimer interface [polypeptide binding]; other site 279010007566 active site 279010007567 dimer interface [polypeptide binding]; other site 279010007568 Conserved membrane protein YqhR; Region: YqhR; pfam11085 279010007569 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 279010007570 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 279010007571 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 279010007572 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 279010007573 active site 279010007574 nucleophile elbow; other site 279010007575 manganese transport transcriptional regulator; Provisional; Region: PRK03902 279010007576 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 279010007577 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 279010007578 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279010007579 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010007580 active site residue [active] 279010007581 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 279010007582 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 279010007583 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 279010007584 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 279010007585 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 279010007586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007587 dimer interface [polypeptide binding]; other site 279010007588 conserved gate region; other site 279010007589 putative PBP binding loops; other site 279010007590 ABC-ATPase subunit interface; other site 279010007591 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 279010007592 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 279010007593 Walker A/P-loop; other site 279010007594 ATP binding site [chemical binding]; other site 279010007595 Q-loop/lid; other site 279010007596 ABC transporter signature motif; other site 279010007597 Walker B; other site 279010007598 D-loop; other site 279010007599 H-loop/switch region; other site 279010007600 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 279010007601 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 279010007602 tetramer interface [polypeptide binding]; other site 279010007603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007604 catalytic residue [active] 279010007605 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 279010007606 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 279010007607 tetramer interface [polypeptide binding]; other site 279010007608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007609 catalytic residue [active] 279010007610 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 279010007611 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 279010007612 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 279010007613 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279010007614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010007615 ATP binding site [chemical binding]; other site 279010007616 putative Mg++ binding site [ion binding]; other site 279010007617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010007618 nucleotide binding region [chemical binding]; other site 279010007619 ATP-binding site [chemical binding]; other site 279010007620 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 279010007621 Anti-repressor SinI; Region: SinI; pfam08671 279010007622 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010007623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010007624 non-specific DNA binding site [nucleotide binding]; other site 279010007625 salt bridge; other site 279010007626 sequence-specific DNA binding site [nucleotide binding]; other site 279010007627 Anti-repressor SinI; Region: SinI; pfam08671 279010007628 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 279010007629 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279010007630 Catalytic site [active] 279010007631 YqxM protein; Region: YqxM_for_SipW; TIGR04087 279010007632 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 279010007633 YqzE-like protein; Region: YqzE; pfam14038 279010007634 ComG operon protein 7; Region: ComGG; pfam14173 279010007635 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 279010007636 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 279010007637 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 279010007638 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 279010007639 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 279010007640 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 279010007641 Type II/IV secretion system protein; Region: T2SE; pfam00437 279010007642 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 279010007643 Walker A motif; other site 279010007644 ATP binding site [chemical binding]; other site 279010007645 Walker B motif; other site 279010007646 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 279010007647 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 279010007648 ArsC family; Region: ArsC; pfam03960 279010007649 putative catalytic residues [active] 279010007650 thiol/disulfide switch; other site 279010007651 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 279010007652 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010007653 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 279010007654 Domain of unknown function DUF77; Region: DUF77; pfam01910 279010007655 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 279010007656 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 279010007657 putative active site [active] 279010007658 Zn binding site [ion binding]; other site 279010007659 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010007660 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 279010007661 putative ligand binding residues [chemical binding]; other site 279010007662 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010007663 Sulfatase; Region: Sulfatase; pfam00884 279010007664 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 279010007665 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010007666 nucleotide binding site [chemical binding]; other site 279010007667 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 279010007668 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010007669 Rhomboid family; Region: Rhomboid; pfam01694 279010007670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010007671 binding surface 279010007672 TPR motif; other site 279010007673 Tetratricopeptide repeat; Region: TPR_16; pfam13432 279010007674 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 279010007675 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 279010007676 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 279010007677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010007678 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 279010007679 YceG-like family; Region: YceG; pfam02618 279010007680 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 279010007681 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 279010007682 Walker A/P-loop; other site 279010007683 ATP binding site [chemical binding]; other site 279010007684 Q-loop/lid; other site 279010007685 ABC transporter signature motif; other site 279010007686 Walker B; other site 279010007687 D-loop; other site 279010007688 H-loop/switch region; other site 279010007689 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 279010007690 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 279010007691 Walker A/P-loop; other site 279010007692 ATP binding site [chemical binding]; other site 279010007693 Q-loop/lid; other site 279010007694 ABC transporter signature motif; other site 279010007695 Walker B; other site 279010007696 D-loop; other site 279010007697 H-loop/switch region; other site 279010007698 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 279010007699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007700 dimer interface [polypeptide binding]; other site 279010007701 conserved gate region; other site 279010007702 ABC-ATPase subunit interface; other site 279010007703 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 279010007704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007705 dimer interface [polypeptide binding]; other site 279010007706 conserved gate region; other site 279010007707 putative PBP binding loops; other site 279010007708 ABC-ATPase subunit interface; other site 279010007709 PBP superfamily domain; Region: PBP_like_2; cl17296 279010007710 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 279010007711 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010007712 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010007713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007715 putative substrate translocation pore; other site 279010007716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010007717 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 279010007718 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 279010007719 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 279010007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 279010007721 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 279010007722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 279010007723 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 279010007724 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 279010007725 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 279010007726 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 279010007727 Uncharacterized conserved protein [Function unknown]; Region: COG5663 279010007728 ferric uptake regulator; Provisional; Region: fur; PRK09462 279010007729 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010007730 metal binding site 2 [ion binding]; metal-binding site 279010007731 putative DNA binding helix; other site 279010007732 metal binding site 1 [ion binding]; metal-binding site 279010007733 dimer interface [polypeptide binding]; other site 279010007734 structural Zn2+ binding site [ion binding]; other site 279010007735 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 279010007736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010007737 ABC-ATPase subunit interface; other site 279010007738 dimer interface [polypeptide binding]; other site 279010007739 putative PBP binding regions; other site 279010007740 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279010007741 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 279010007742 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010007743 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010007744 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010007745 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 279010007746 endonuclease IV; Provisional; Region: PRK01060 279010007747 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 279010007748 AP (apurinic/apyrimidinic) site pocket; other site 279010007749 DNA interaction; other site 279010007750 Metal-binding active site; metal-binding site 279010007751 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010007752 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279010007753 ATP binding site [chemical binding]; other site 279010007754 Mg++ binding site [ion binding]; other site 279010007755 motif III; other site 279010007756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010007757 nucleotide binding region [chemical binding]; other site 279010007758 ATP-binding site [chemical binding]; other site 279010007759 YqfQ-like protein; Region: YqfQ; pfam14181 279010007760 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 279010007761 LytB protein; Region: LYTB; pfam02401 279010007762 Uncharacterized conserved protein [Function unknown]; Region: COG0327 279010007763 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 279010007764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 279010007765 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 279010007766 Uncharacterized conserved protein [Function unknown]; Region: COG0327 279010007767 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 279010007768 Family of unknown function (DUF633); Region: DUF633; pfam04816 279010007769 Uncharacterized conserved protein [Function unknown]; Region: COG5444 279010007770 Immunity protein Imm6; Region: Imm6; pfam14434 279010007771 Immunity protein Imm6; Region: Imm6; pfam14434 279010007772 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010007773 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010007774 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 279010007775 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 279010007776 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 279010007777 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 279010007778 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 279010007779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010007780 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010007781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010007782 DNA binding residues [nucleotide binding] 279010007783 DNA primase; Validated; Region: dnaG; PRK05667 279010007784 CHC2 zinc finger; Region: zf-CHC2; pfam01807 279010007785 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 279010007786 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 279010007787 active site 279010007788 metal binding site [ion binding]; metal-binding site 279010007789 interdomain interaction site; other site 279010007790 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 279010007791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 279010007792 PEP synthetase regulatory protein; Provisional; Region: PRK05339 279010007793 HTH domain; Region: HTH_11; pfam08279 279010007794 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 279010007795 FOG: CBS domain [General function prediction only]; Region: COG0517 279010007796 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 279010007797 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 279010007798 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 279010007799 dimer interface [polypeptide binding]; other site 279010007800 motif 1; other site 279010007801 active site 279010007802 motif 2; other site 279010007803 motif 3; other site 279010007804 Recombination protein O N terminal; Region: RecO_N; pfam11967 279010007805 DNA repair protein RecO; Region: reco; TIGR00613 279010007806 Recombination protein O C terminal; Region: RecO_C; pfam02565 279010007807 GTPase Era; Reviewed; Region: era; PRK00089 279010007808 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 279010007809 G1 box; other site 279010007810 GTP/Mg2+ binding site [chemical binding]; other site 279010007811 Switch I region; other site 279010007812 G2 box; other site 279010007813 Switch II region; other site 279010007814 G3 box; other site 279010007815 G4 box; other site 279010007816 G5 box; other site 279010007817 KH domain; Region: KH_2; pfam07650 279010007818 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 279010007819 active site 279010007820 catalytic motif [active] 279010007821 Zn binding site [ion binding]; other site 279010007822 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 279010007823 metal-binding heat shock protein; Provisional; Region: PRK00016 279010007824 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 279010007825 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 279010007826 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010007827 Zn2+ binding site [ion binding]; other site 279010007828 Mg2+ binding site [ion binding]; other site 279010007829 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 279010007830 PhoH-like protein; Region: PhoH; pfam02562 279010007831 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 279010007832 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 279010007833 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 279010007834 hypothetical protein; Provisional; Region: PRK13665 279010007835 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 279010007836 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 279010007837 dimer interface [polypeptide binding]; other site 279010007838 active site residues [active] 279010007839 Yqey-like protein; Region: YqeY; pfam09424 279010007840 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 279010007841 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 279010007842 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010007843 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010007844 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 279010007845 intersubunit interface [polypeptide binding]; other site 279010007846 active site 279010007847 catalytic residue [active] 279010007848 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 279010007849 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 279010007850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010007851 FeS/SAM binding site; other site 279010007852 TRAM domain; Region: TRAM; cl01282 279010007853 RNA methyltransferase, RsmE family; Region: TIGR00046 279010007854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 279010007855 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 279010007856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007857 S-adenosylmethionine binding site [chemical binding]; other site 279010007858 chaperone protein DnaJ; Provisional; Region: PRK14280 279010007859 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 279010007860 HSP70 interaction site [polypeptide binding]; other site 279010007861 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 279010007862 substrate binding site [polypeptide binding]; other site 279010007863 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 279010007864 Zn binding sites [ion binding]; other site 279010007865 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 279010007866 dimer interface [polypeptide binding]; other site 279010007867 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 279010007868 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 279010007869 nucleotide binding site [chemical binding]; other site 279010007870 NEF interaction site [polypeptide binding]; other site 279010007871 SBD interface [polypeptide binding]; other site 279010007872 heat shock protein GrpE; Provisional; Region: PRK14140 279010007873 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 279010007874 dimer interface [polypeptide binding]; other site 279010007875 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 279010007876 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 279010007877 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 279010007878 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 279010007879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010007880 FeS/SAM binding site; other site 279010007881 HemN C-terminal domain; Region: HemN_C; pfam06969 279010007882 GTP-binding protein LepA; Provisional; Region: PRK05433 279010007883 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 279010007884 G1 box; other site 279010007885 putative GEF interaction site [polypeptide binding]; other site 279010007886 GTP/Mg2+ binding site [chemical binding]; other site 279010007887 Switch I region; other site 279010007888 G2 box; other site 279010007889 G3 box; other site 279010007890 Switch II region; other site 279010007891 G4 box; other site 279010007892 G5 box; other site 279010007893 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 279010007894 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 279010007895 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 279010007896 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 279010007897 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 279010007898 stage II sporulation protein P; Region: spore_II_P; TIGR02867 279010007899 germination protease; Provisional; Region: PRK02858 279010007900 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 279010007901 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 279010007902 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 279010007903 YqzM-like protein; Region: YqzM; pfam14141 279010007904 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 279010007905 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 279010007906 Competence protein; Region: Competence; pfam03772 279010007907 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010007908 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 279010007909 catalytic motif [active] 279010007910 Zn binding site [ion binding]; other site 279010007911 SLBB domain; Region: SLBB; pfam10531 279010007912 comEA protein; Region: comE; TIGR01259 279010007913 Helix-hairpin-helix motif; Region: HHH; pfam00633 279010007914 late competence protein ComER; Validated; Region: PRK07680 279010007915 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 279010007916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007917 S-adenosylmethionine binding site [chemical binding]; other site 279010007918 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 279010007919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010007920 Zn2+ binding site [ion binding]; other site 279010007921 Mg2+ binding site [ion binding]; other site 279010007922 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 279010007923 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 279010007924 active site 279010007925 (T/H)XGH motif; other site 279010007926 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 279010007927 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 279010007928 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 279010007929 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 279010007930 shikimate binding site; other site 279010007931 NAD(P) binding site [chemical binding]; other site 279010007932 GTPase YqeH; Provisional; Region: PRK13796 279010007933 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 279010007934 GTP/Mg2+ binding site [chemical binding]; other site 279010007935 G4 box; other site 279010007936 G5 box; other site 279010007937 G1 box; other site 279010007938 Switch I region; other site 279010007939 G2 box; other site 279010007940 G3 box; other site 279010007941 Switch II region; other site 279010007942 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 279010007943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010007944 active site 279010007945 motif I; other site 279010007946 motif II; other site 279010007947 Sporulation inhibitor A; Region: Sda; pfam08970 279010007948 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 279010007949 active site 279010007950 catalytic triad [active] 279010007951 oxyanion hole [active] 279010007952 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 279010007953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010007954 Uncharacterized conserved protein [Function unknown]; Region: COG5609 279010007955 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 279010007956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 279010007957 catalytic loop [active] 279010007958 iron binding site [ion binding]; other site 279010007959 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 279010007960 4Fe-4S binding domain; Region: Fer4; pfam00037 279010007961 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 279010007962 [4Fe-4S] binding site [ion binding]; other site 279010007963 molybdopterin cofactor binding site; other site 279010007964 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 279010007965 molybdopterin cofactor binding site; other site 279010007966 Uncharacterized conserved protein [Function unknown]; Region: COG2427 279010007967 sporulation sigma factor SigK; Reviewed; Region: PRK05803 279010007968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010007969 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010007970 DNA binding residues [nucleotide binding] 279010007971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007972 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279010007973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010007974 Coenzyme A binding pocket [chemical binding]; other site 279010007975 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 279010007976 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 279010007977 DHHA1 domain; Region: DHHA1; pfam02272 279010007978 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 279010007979 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 279010007980 dimer interface [polypeptide binding]; other site 279010007981 active site 279010007982 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010007983 substrate binding site [chemical binding]; other site 279010007984 catalytic residue [active] 279010007985 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279010007986 homotrimer interaction site [polypeptide binding]; other site 279010007987 putative active site [active] 279010007988 threonine synthase; Validated; Region: PRK06260 279010007989 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 279010007990 homodimer interface [polypeptide binding]; other site 279010007991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007992 catalytic residue [active] 279010007993 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279010007994 homotrimer interaction site [polypeptide binding]; other site 279010007995 putative active site [active] 279010007996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 279010007997 YheO-like PAS domain; Region: PAS_6; pfam08348 279010007998 HTH domain; Region: HTH_22; pfam13309 279010007999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010008000 DNA binding residues [nucleotide binding] 279010008001 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 279010008002 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010008003 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 279010008004 DNA binding residues [nucleotide binding] 279010008005 drug binding residues [chemical binding]; other site 279010008006 dimer interface [polypeptide binding]; other site 279010008007 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010008008 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010008009 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010008010 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010008011 active site residue [active] 279010008012 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 279010008013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010008014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010008015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010008016 active site 279010008017 phosphorylation site [posttranslational modification] 279010008018 intermolecular recognition site; other site 279010008019 dimerization interface [polypeptide binding]; other site 279010008020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010008021 DNA binding residues [nucleotide binding] 279010008022 dimerization interface [polypeptide binding]; other site 279010008023 PAS domain S-box; Region: sensory_box; TIGR00229 279010008024 PAS domain; Region: PAS_8; pfam13188 279010008025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 279010008026 Histidine kinase; Region: HisKA_3; pfam07730 279010008027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010008028 ATP binding site [chemical binding]; other site 279010008029 Mg2+ binding site [ion binding]; other site 279010008030 G-X-G motif; other site 279010008031 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010008032 catalytic residues [active] 279010008033 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279010008034 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 279010008035 CPxP motif; other site 279010008036 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 279010008037 active site residue [active] 279010008038 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010008039 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 279010008040 CPxP motif; other site 279010008041 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010008042 active site residue [active] 279010008043 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 279010008044 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 279010008045 putative homodimer interface [polypeptide binding]; other site 279010008046 putative homotetramer interface [polypeptide binding]; other site 279010008047 putative metal binding site [ion binding]; other site 279010008048 putative homodimer-homodimer interface [polypeptide binding]; other site 279010008049 putative allosteric switch controlling residues; other site 279010008050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010008051 S-adenosylmethionine binding site [chemical binding]; other site 279010008052 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 279010008053 A new structural DNA glycosylase; Region: AlkD_like; cd06561 279010008054 active site 279010008055 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010008056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 279010008057 Domain of unknown function (DUF303); Region: DUF303; pfam03629 279010008058 Haemolytic domain; Region: Haemolytic; pfam01809 279010008059 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 279010008060 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 279010008061 tetramer interface [polypeptide binding]; other site 279010008062 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010008063 active site 279010008064 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 279010008065 active site 279010008066 dimer interface [polypeptide binding]; other site 279010008067 magnesium binding site [ion binding]; other site 279010008068 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010008069 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279010008070 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 279010008071 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 279010008072 putative di-iron ligands [ion binding]; other site 279010008073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010008074 Histidine kinase; Region: HisKA_3; pfam07730 279010008075 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 279010008076 ATP binding site [chemical binding]; other site 279010008077 Mg2+ binding site [ion binding]; other site 279010008078 G-X-G motif; other site 279010008079 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010008080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010008081 active site 279010008082 phosphorylation site [posttranslational modification] 279010008083 intermolecular recognition site; other site 279010008084 dimerization interface [polypeptide binding]; other site 279010008085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010008086 DNA binding residues [nucleotide binding] 279010008087 dimerization interface [polypeptide binding]; other site 279010008088 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279010008089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010008090 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279010008091 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 279010008092 substrate binding site [chemical binding]; other site 279010008093 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 279010008094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008095 dimer interface [polypeptide binding]; other site 279010008096 conserved gate region; other site 279010008097 putative PBP binding loops; other site 279010008098 ABC-ATPase subunit interface; other site 279010008099 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 279010008100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008101 dimer interface [polypeptide binding]; other site 279010008102 conserved gate region; other site 279010008103 putative PBP binding loops; other site 279010008104 ABC-ATPase subunit interface; other site 279010008105 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010008106 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 279010008107 Walker A/P-loop; other site 279010008108 ATP binding site [chemical binding]; other site 279010008109 Q-loop/lid; other site 279010008110 ABC transporter signature motif; other site 279010008111 Walker B; other site 279010008112 D-loop; other site 279010008113 H-loop/switch region; other site 279010008114 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010008115 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 279010008116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279010008117 Walker A/P-loop; other site 279010008118 ATP binding site [chemical binding]; other site 279010008119 Q-loop/lid; other site 279010008120 ABC transporter signature motif; other site 279010008121 Walker B; other site 279010008122 D-loop; other site 279010008123 H-loop/switch region; other site 279010008124 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010008125 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 279010008126 DNA binding residues [nucleotide binding] 279010008127 drug binding residues [chemical binding]; other site 279010008128 dimer interface [polypeptide binding]; other site 279010008129 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010008130 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 279010008131 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 279010008132 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 279010008133 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 279010008134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010008135 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 279010008136 classical (c) SDRs; Region: SDR_c; cd05233 279010008137 NAD(P) binding site [chemical binding]; other site 279010008138 active site 279010008139 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 279010008140 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279010008141 active site 279010008142 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 279010008143 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 279010008144 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010008145 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279010008146 Cytochrome P450; Region: p450; cl12078 279010008147 hypothetical protein; Provisional; Region: PRK10621 279010008148 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279010008149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010008150 classical (c) SDRs; Region: SDR_c; cd05233 279010008151 NAD(P) binding site [chemical binding]; other site 279010008152 active site 279010008153 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 279010008154 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010008155 substrate binding [chemical binding]; other site 279010008156 active site 279010008157 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010008158 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 279010008159 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 279010008160 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 279010008161 active site 279010008162 phosphorylation site [posttranslational modification] 279010008163 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 279010008164 active pocket/dimerization site; other site 279010008165 active site 279010008166 phosphorylation site [posttranslational modification] 279010008167 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 279010008168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008169 ATP binding site [chemical binding]; other site 279010008170 Walker A motif; other site 279010008171 Walker B motif; other site 279010008172 arginine finger; other site 279010008173 Transcriptional antiterminator [Transcription]; Region: COG3933 279010008174 PRD domain; Region: PRD; pfam00874 279010008175 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 279010008176 active pocket/dimerization site; other site 279010008177 active site 279010008178 phosphorylation site [posttranslational modification] 279010008179 PRD domain; Region: PRD; pfam00874 279010008180 YrhK-like protein; Region: YrhK; pfam14145 279010008181 Chloramphenicol acetyltransferase; Region: CAT; cl02008 279010008182 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 279010008183 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 279010008184 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 279010008185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010008186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010008187 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 279010008188 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 279010008189 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 279010008190 DNA binding site [nucleotide binding] 279010008191 active site 279010008192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010008193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010008194 active site 279010008195 catalytic tetrad [active] 279010008196 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010008197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010008198 putative substrate translocation pore; other site 279010008199 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010008200 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279010008201 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 279010008202 active site pocket [active] 279010008203 oxyanion hole [active] 279010008204 catalytic triad [active] 279010008205 active site nucleophile [active] 279010008206 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 279010008207 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 279010008208 active site 279010008209 Cupin domain; Region: Cupin_2; cl17218 279010008210 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010008211 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010008212 intersubunit interface [polypeptide binding]; other site 279010008213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010008214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010008215 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 279010008216 putative dimerization interface [polypeptide binding]; other site 279010008217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010008218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010008219 putative substrate translocation pore; other site 279010008220 YoqO-like protein; Region: YoqO; pfam14037 279010008221 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279010008222 Cytochrome P450; Region: p450; pfam00067 279010008223 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 279010008224 Flavodoxin; Region: Flavodoxin_1; pfam00258 279010008225 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 279010008226 FAD binding pocket [chemical binding]; other site 279010008227 FAD binding motif [chemical binding]; other site 279010008228 catalytic residues [active] 279010008229 NAD binding pocket [chemical binding]; other site 279010008230 phosphate binding motif [ion binding]; other site 279010008231 beta-alpha-beta structure motif; other site 279010008232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010008233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010008234 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 279010008235 active site 279010008236 catalytic triad [active] 279010008237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010008238 S-adenosylmethionine binding site [chemical binding]; other site 279010008239 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 279010008240 YrhC-like protein; Region: YrhC; pfam14143 279010008241 cystathionine beta-lyase; Provisional; Region: PRK07671 279010008242 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279010008243 homodimer interface [polypeptide binding]; other site 279010008244 substrate-cofactor binding pocket; other site 279010008245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008246 catalytic residue [active] 279010008247 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279010008248 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279010008249 dimer interface [polypeptide binding]; other site 279010008250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008251 catalytic residue [active] 279010008252 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 279010008253 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 279010008254 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279010008255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010008256 S-adenosylmethionine binding site [chemical binding]; other site 279010008257 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 279010008258 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 279010008259 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010008260 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010008261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279010008262 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 279010008263 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 279010008264 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 279010008265 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 279010008266 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 279010008267 ATP-binding site [chemical binding]; other site 279010008268 Sugar specificity; other site 279010008269 Pyrimidine base specificity; other site 279010008270 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 279010008271 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 279010008272 Peptidase family U32; Region: Peptidase_U32; pfam01136 279010008273 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 279010008274 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 279010008275 Peptidase family U32; Region: Peptidase_U32; pfam01136 279010008276 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 279010008277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010008278 S-adenosylmethionine binding site [chemical binding]; other site 279010008279 YceG-like family; Region: YceG; pfam02618 279010008280 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 279010008281 dimerization interface [polypeptide binding]; other site 279010008282 hypothetical protein; Provisional; Region: PRK13678 279010008283 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 279010008284 hypothetical protein; Provisional; Region: PRK05473 279010008285 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 279010008286 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 279010008287 motif 1; other site 279010008288 active site 279010008289 motif 2; other site 279010008290 motif 3; other site 279010008291 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 279010008292 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 279010008293 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010008294 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 279010008295 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 279010008296 AAA domain; Region: AAA_30; pfam13604 279010008297 Family description; Region: UvrD_C_2; pfam13538 279010008298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010008299 binding surface 279010008300 TPR repeat; Region: TPR_11; pfam13414 279010008301 TPR motif; other site 279010008302 TPR repeat; Region: TPR_11; pfam13414 279010008303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010008304 binding surface 279010008305 TPR motif; other site 279010008306 TPR repeat; Region: TPR_11; pfam13414 279010008307 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 279010008308 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 279010008309 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 279010008310 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 279010008311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010008312 catalytic residue [active] 279010008313 Predicted transcriptional regulator [Transcription]; Region: COG1959 279010008314 Transcriptional regulator; Region: Rrf2; pfam02082 279010008315 recombination factor protein RarA; Reviewed; Region: PRK13342 279010008316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008317 Walker A motif; other site 279010008318 ATP binding site [chemical binding]; other site 279010008319 Walker B motif; other site 279010008320 arginine finger; other site 279010008321 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 279010008322 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 279010008323 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 279010008324 putative ATP binding site [chemical binding]; other site 279010008325 putative substrate interface [chemical binding]; other site 279010008326 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 279010008327 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 279010008328 dimer interface [polypeptide binding]; other site 279010008329 anticodon binding site; other site 279010008330 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 279010008331 homodimer interface [polypeptide binding]; other site 279010008332 motif 1; other site 279010008333 active site 279010008334 motif 2; other site 279010008335 GAD domain; Region: GAD; pfam02938 279010008336 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 279010008337 motif 3; other site 279010008338 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 279010008339 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 279010008340 dimer interface [polypeptide binding]; other site 279010008341 motif 1; other site 279010008342 active site 279010008343 motif 2; other site 279010008344 motif 3; other site 279010008345 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 279010008346 anticodon binding site; other site 279010008347 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 279010008348 Bacterial SH3 domain; Region: SH3_3; pfam08239 279010008349 Bacterial SH3 domain; Region: SH3_3; pfam08239 279010008350 Bacterial SH3 domain; Region: SH3_3; pfam08239 279010008351 Bacterial SH3 domain homologues; Region: SH3b; smart00287 279010008352 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010008353 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010008354 active site 279010008355 metal binding site [ion binding]; metal-binding site 279010008356 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 279010008357 putative active site [active] 279010008358 dimerization interface [polypeptide binding]; other site 279010008359 putative tRNAtyr binding site [nucleotide binding]; other site 279010008360 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 279010008361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010008362 Zn2+ binding site [ion binding]; other site 279010008363 Mg2+ binding site [ion binding]; other site 279010008364 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279010008365 synthetase active site [active] 279010008366 NTP binding site [chemical binding]; other site 279010008367 metal binding site [ion binding]; metal-binding site 279010008368 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 279010008369 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 279010008370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010008371 active site 279010008372 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 279010008373 DHH family; Region: DHH; pfam01368 279010008374 DHHA1 domain; Region: DHHA1; pfam02272 279010008375 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 279010008376 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 279010008377 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 279010008378 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 279010008379 Protein export membrane protein; Region: SecD_SecF; pfam02355 279010008380 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 279010008381 stage V sporulation protein B; Region: spore_V_B; TIGR02900 279010008382 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 279010008383 Predicted membrane protein [Function unknown]; Region: COG2323 279010008384 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 279010008385 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 279010008386 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 279010008387 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 279010008388 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 279010008389 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 279010008390 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 279010008391 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 279010008392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008393 Walker A motif; other site 279010008394 ATP binding site [chemical binding]; other site 279010008395 Walker B motif; other site 279010008396 arginine finger; other site 279010008397 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 279010008398 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 279010008399 RuvA N terminal domain; Region: RuvA_N; pfam01330 279010008400 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 279010008401 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 279010008402 BofC C-terminal domain; Region: BofC_C; pfam08955 279010008403 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010008404 active site 279010008405 ATP binding site [chemical binding]; other site 279010008406 substrate binding site [chemical binding]; other site 279010008407 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 279010008408 DinB family; Region: DinB; cl17821 279010008409 DinB superfamily; Region: DinB_2; pfam12867 279010008410 Protein of unknown function (DUF867); Region: DUF867; pfam05908 279010008411 hypothetical protein; Validated; Region: PRK00110 279010008412 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010008413 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 279010008414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010008415 quinolinate synthetase; Provisional; Region: PRK09375 279010008416 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 279010008417 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 279010008418 dimerization interface [polypeptide binding]; other site 279010008419 active site 279010008420 L-aspartate oxidase; Provisional; Region: PRK08071 279010008421 L-aspartate oxidase; Provisional; Region: PRK06175 279010008422 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 279010008423 cysteine desulfurase; Provisional; Region: PRK02948 279010008424 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 279010008425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010008426 catalytic residue [active] 279010008427 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 279010008428 HTH domain; Region: HTH_11; pfam08279 279010008429 3H domain; Region: 3H; pfam02829 279010008430 prephenate dehydratase; Provisional; Region: PRK11898 279010008431 Prephenate dehydratase; Region: PDT; pfam00800 279010008432 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 279010008433 putative L-Phe binding site [chemical binding]; other site 279010008434 hypothetical protein; Provisional; Region: PRK04435 279010008435 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 279010008436 GTPase CgtA; Reviewed; Region: obgE; PRK12297 279010008437 GTP1/OBG; Region: GTP1_OBG; pfam01018 279010008438 Obg GTPase; Region: Obg; cd01898 279010008439 G1 box; other site 279010008440 GTP/Mg2+ binding site [chemical binding]; other site 279010008441 Switch I region; other site 279010008442 G2 box; other site 279010008443 G3 box; other site 279010008444 Switch II region; other site 279010008445 G4 box; other site 279010008446 G5 box; other site 279010008447 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 279010008448 sensory histidine kinase DcuS; Provisional; Region: PRK11086 279010008449 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 279010008450 hypothetical protein; Provisional; Region: PRK14553 279010008451 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 279010008452 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 279010008453 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 279010008454 Peptidase family M50; Region: Peptidase_M50; pfam02163 279010008455 active site 279010008456 putative substrate binding region [chemical binding]; other site 279010008457 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279010008458 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010008459 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 279010008460 putative hydrophobic ligand binding site [chemical binding]; other site 279010008461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010008462 dimerization interface [polypeptide binding]; other site 279010008463 putative DNA binding site [nucleotide binding]; other site 279010008464 putative Zn2+ binding site [ion binding]; other site 279010008465 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 279010008466 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 279010008467 Switch I; other site 279010008468 Switch II; other site 279010008469 septum formation inhibitor; Reviewed; Region: minC; PRK00513 279010008470 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 279010008471 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 279010008472 rod shape-determining protein MreC; Provisional; Region: PRK13922 279010008473 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 279010008474 rod shape-determining protein MreC; Region: MreC; pfam04085 279010008475 rod shape-determining protein MreB; Provisional; Region: PRK13927 279010008476 MreB and similar proteins; Region: MreB_like; cd10225 279010008477 nucleotide binding site [chemical binding]; other site 279010008478 Mg binding site [ion binding]; other site 279010008479 putative protofilament interaction site [polypeptide binding]; other site 279010008480 RodZ interaction site [polypeptide binding]; other site 279010008481 hypothetical protein; Reviewed; Region: PRK00024 279010008482 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 279010008483 MPN+ (JAMM) motif; other site 279010008484 Zinc-binding site [ion binding]; other site 279010008485 Maf-like protein; Region: Maf; pfam02545 279010008486 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 279010008487 active site 279010008488 dimer interface [polypeptide binding]; other site 279010008489 Sporulation related domain; Region: SPOR; pfam05036 279010008490 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 279010008491 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 279010008492 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 279010008493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010008494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010008495 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 279010008496 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 279010008497 active site 279010008498 HIGH motif; other site 279010008499 nucleotide binding site [chemical binding]; other site 279010008500 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279010008501 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 279010008502 active site 279010008503 KMSKS motif; other site 279010008504 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 279010008505 tRNA binding surface [nucleotide binding]; other site 279010008506 anticodon binding site; other site 279010008507 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 279010008508 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 279010008509 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 279010008510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279010008511 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 279010008512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010008513 inhibitor-cofactor binding pocket; inhibition site 279010008514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008515 catalytic residue [active] 279010008516 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 279010008517 dimer interface [polypeptide binding]; other site 279010008518 active site 279010008519 Schiff base residues; other site 279010008520 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 279010008521 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 279010008522 active site 279010008523 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 279010008524 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 279010008525 domain interfaces; other site 279010008526 active site 279010008527 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 279010008528 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 279010008529 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 279010008530 tRNA; other site 279010008531 putative tRNA binding site [nucleotide binding]; other site 279010008532 putative NADP binding site [chemical binding]; other site 279010008533 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 279010008534 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 279010008535 G1 box; other site 279010008536 GTP/Mg2+ binding site [chemical binding]; other site 279010008537 Switch I region; other site 279010008538 G2 box; other site 279010008539 G3 box; other site 279010008540 Switch II region; other site 279010008541 G4 box; other site 279010008542 G5 box; other site 279010008543 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 279010008544 Found in ATP-dependent protease La (LON); Region: LON; smart00464 279010008545 Found in ATP-dependent protease La (LON); Region: LON; smart00464 279010008546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008547 Walker A motif; other site 279010008548 ATP binding site [chemical binding]; other site 279010008549 Walker B motif; other site 279010008550 arginine finger; other site 279010008551 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 279010008552 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 279010008553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008554 Walker A motif; other site 279010008555 ATP binding site [chemical binding]; other site 279010008556 Walker B motif; other site 279010008557 arginine finger; other site 279010008558 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 279010008559 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 279010008560 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 279010008561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008562 Walker A motif; other site 279010008563 ATP binding site [chemical binding]; other site 279010008564 Walker B motif; other site 279010008565 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 279010008566 trigger factor; Provisional; Region: tig; PRK01490 279010008567 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 279010008568 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 279010008569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010008570 binding surface 279010008571 Tetratricopeptide repeat; Region: TPR_16; pfam13432 279010008572 TPR motif; other site 279010008573 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 279010008574 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 279010008575 substrate binding site [chemical binding]; other site 279010008576 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 279010008577 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 279010008578 substrate binding site [chemical binding]; other site 279010008579 ligand binding site [chemical binding]; other site 279010008580 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 279010008581 tartrate dehydrogenase; Region: TTC; TIGR02089 279010008582 2-isopropylmalate synthase; Validated; Region: PRK00915 279010008583 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 279010008584 active site 279010008585 catalytic residues [active] 279010008586 metal binding site [ion binding]; metal-binding site 279010008587 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 279010008588 ketol-acid reductoisomerase; Provisional; Region: PRK05479 279010008589 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 279010008590 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 279010008591 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 279010008592 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 279010008593 putative valine binding site [chemical binding]; other site 279010008594 dimer interface [polypeptide binding]; other site 279010008595 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 279010008596 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 279010008597 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279010008598 PYR/PP interface [polypeptide binding]; other site 279010008599 dimer interface [polypeptide binding]; other site 279010008600 TPP binding site [chemical binding]; other site 279010008601 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279010008602 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 279010008603 TPP-binding site [chemical binding]; other site 279010008604 dimer interface [polypeptide binding]; other site 279010008605 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 279010008606 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 279010008607 homodimer interface [polypeptide binding]; other site 279010008608 substrate-cofactor binding pocket; other site 279010008609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008610 catalytic residue [active] 279010008611 glutamate dehydrogenase; Provisional; Region: PRK09414 279010008612 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279010008613 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 279010008614 NAD(P) binding site [chemical binding]; other site 279010008615 'prophage region BLi_Pp5, putative skin element proteins' 279010008616 Phage-related protein [Function unknown]; Region: COG4695; cl01923 279010008617 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 279010008618 Terminase-like family; Region: Terminase_6; pfam03237 279010008619 Uncharacterized conserved protein [Function unknown]; Region: COG5484 279010008620 Phage terminase small subunit; Region: Phage_terminase; pfam10668 279010008621 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 279010008622 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 279010008623 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 279010008624 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 279010008625 cofactor binding site; other site 279010008626 DNA binding site [nucleotide binding] 279010008627 substrate interaction site [chemical binding]; other site 279010008628 Protein of unknown function, DUF600; Region: DUF600; pfam04634 279010008629 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010008630 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 279010008631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 279010008632 binding surface 279010008633 TPR motif; other site 279010008634 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010008635 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 279010008636 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 279010008637 active site 279010008638 metal binding site [ion binding]; metal-binding site 279010008639 homotetramer interface [polypeptide binding]; other site 279010008640 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 279010008641 active site 279010008642 dimerization interface [polypeptide binding]; other site 279010008643 ribonuclease PH; Reviewed; Region: rph; PRK00173 279010008644 Ribonuclease PH; Region: RNase_PH_bact; cd11362 279010008645 hexamer interface [polypeptide binding]; other site 279010008646 active site 279010008647 Sporulation and spore germination; Region: Germane; pfam10646 279010008648 Spore germination protein [General function prediction only]; Region: COG5401 279010008649 Sporulation and spore germination; Region: Germane; pfam10646 279010008650 glutamate racemase; Provisional; Region: PRK00865 279010008651 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010008652 MarR family; Region: MarR; pfam01047 279010008653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010008654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010008655 DNA binding residues [nucleotide binding] 279010008656 dimerization interface [polypeptide binding]; other site 279010008657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008658 short chain dehydrogenase; Provisional; Region: PRK05693 279010008659 NAD(P) binding site [chemical binding]; other site 279010008660 active site 279010008661 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279010008662 active site 279010008663 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 279010008664 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 279010008665 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 279010008666 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 279010008667 L-aspartate oxidase; Provisional; Region: PRK06175 279010008668 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 279010008669 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 279010008670 putative Iron-sulfur protein interface [polypeptide binding]; other site 279010008671 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 279010008672 proximal heme binding site [chemical binding]; other site 279010008673 distal heme binding site [chemical binding]; other site 279010008674 putative dimer interface [polypeptide binding]; other site 279010008675 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 279010008676 aspartate kinase; Reviewed; Region: PRK06635 279010008677 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 279010008678 putative nucleotide binding site [chemical binding]; other site 279010008679 putative catalytic residues [active] 279010008680 putative Mg ion binding site [ion binding]; other site 279010008681 putative aspartate binding site [chemical binding]; other site 279010008682 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 279010008683 putative allosteric regulatory site; other site 279010008684 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 279010008685 putative allosteric regulatory residue; other site 279010008686 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 279010008687 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 279010008688 GIY-YIG motif/motif A; other site 279010008689 active site 279010008690 catalytic site [active] 279010008691 putative DNA binding site [nucleotide binding]; other site 279010008692 metal binding site [ion binding]; metal-binding site 279010008693 UvrB/uvrC motif; Region: UVR; pfam02151 279010008694 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 279010008695 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010008696 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279010008697 catalytic residues [active] 279010008698 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 279010008699 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 279010008700 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 279010008701 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 279010008702 Ligand binding site [chemical binding]; other site 279010008703 Electron transfer flavoprotein domain; Region: ETF; pfam01012 279010008704 enoyl-CoA hydratase; Provisional; Region: PRK07658 279010008705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010008706 substrate binding site [chemical binding]; other site 279010008707 oxyanion hole (OAH) forming residues; other site 279010008708 trimer interface [polypeptide binding]; other site 279010008709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010008710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010008711 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 279010008712 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 279010008713 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 279010008714 acyl-activating enzyme (AAE) consensus motif; other site 279010008715 putative AMP binding site [chemical binding]; other site 279010008716 putative active site [active] 279010008717 putative CoA binding site [chemical binding]; other site 279010008718 Predicted membrane protein [Function unknown]; Region: COG3766 279010008719 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 279010008720 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 279010008721 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 279010008722 MutS domain III; Region: MutS_III; pfam05192 279010008723 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 279010008724 Walker A/P-loop; other site 279010008725 ATP binding site [chemical binding]; other site 279010008726 Q-loop/lid; other site 279010008727 ABC transporter signature motif; other site 279010008728 Walker B; other site 279010008729 D-loop; other site 279010008730 H-loop/switch region; other site 279010008731 Smr domain; Region: Smr; pfam01713 279010008732 hypothetical protein; Provisional; Region: PRK08609 279010008733 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 279010008734 active site 279010008735 primer binding site [nucleotide binding]; other site 279010008736 NTP binding site [chemical binding]; other site 279010008737 metal binding triad [ion binding]; metal-binding site 279010008738 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 279010008739 active site 279010008740 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 279010008741 Colicin V production protein; Region: Colicin_V; pfam02674 279010008742 cell division protein ZapA; Provisional; Region: PRK14126 279010008743 ribonuclease HIII; Provisional; Region: PRK00996 279010008744 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 279010008745 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 279010008746 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010008747 active site 279010008748 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279010008749 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010008750 Walker A/P-loop; other site 279010008751 ATP binding site [chemical binding]; other site 279010008752 Q-loop/lid; other site 279010008753 ABC transporter signature motif; other site 279010008754 Walker B; other site 279010008755 D-loop; other site 279010008756 H-loop/switch region; other site 279010008757 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 279010008758 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 279010008759 putative tRNA-binding site [nucleotide binding]; other site 279010008760 B3/4 domain; Region: B3_4; pfam03483 279010008761 tRNA synthetase B5 domain; Region: B5; smart00874 279010008762 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 279010008763 dimer interface [polypeptide binding]; other site 279010008764 motif 1; other site 279010008765 motif 3; other site 279010008766 motif 2; other site 279010008767 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 279010008768 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 279010008769 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 279010008770 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 279010008771 dimer interface [polypeptide binding]; other site 279010008772 motif 1; other site 279010008773 active site 279010008774 motif 2; other site 279010008775 motif 3; other site 279010008776 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 279010008777 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 279010008778 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 279010008779 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 279010008780 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 279010008781 Carbon starvation protein CstA; Region: CstA; pfam02554 279010008782 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 279010008783 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 279010008784 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 279010008785 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010008786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008787 dimer interface [polypeptide binding]; other site 279010008788 conserved gate region; other site 279010008789 putative PBP binding loops; other site 279010008790 ABC-ATPase subunit interface; other site 279010008791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008792 dimer interface [polypeptide binding]; other site 279010008793 conserved gate region; other site 279010008794 putative PBP binding loops; other site 279010008795 ABC-ATPase subunit interface; other site 279010008796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010008797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010008798 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 279010008799 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010008800 active site 279010008801 metal binding site [ion binding]; metal-binding site 279010008802 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 279010008803 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 279010008804 intersubunit interface [polypeptide binding]; other site 279010008805 active site 279010008806 Zn2+ binding site [ion binding]; other site 279010008807 ribulokinase; Provisional; Region: PRK04123 279010008808 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 279010008809 active site 279010008810 MgATP binding site [chemical binding]; other site 279010008811 N- and C-terminal domain interface [polypeptide binding]; other site 279010008812 carbohydrate binding site [chemical binding]; other site 279010008813 homodimer interface [polypeptide binding]; other site 279010008814 L-arabinose isomerase; Provisional; Region: PRK02929 279010008815 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 279010008816 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010008817 trimer interface [polypeptide binding]; other site 279010008818 putative substrate binding site [chemical binding]; other site 279010008819 putative metal binding site [ion binding]; other site 279010008820 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 279010008821 substrate binding site [chemical binding]; other site 279010008822 active site 279010008823 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279010008824 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 279010008825 oligomer interface [polypeptide binding]; other site 279010008826 active site 279010008827 metal binding site [ion binding]; metal-binding site 279010008828 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 279010008829 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 279010008830 23S rRNA binding site [nucleotide binding]; other site 279010008831 L21 binding site [polypeptide binding]; other site 279010008832 L13 binding site [polypeptide binding]; other site 279010008833 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 279010008834 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 279010008835 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 279010008836 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 279010008837 antiholin-like protein LrgB; Provisional; Region: PRK04288 279010008838 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 279010008839 PhoD-like phosphatase; Region: PhoD; pfam09423 279010008840 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 279010008841 putative active site [active] 279010008842 putative metal binding site [ion binding]; other site 279010008843 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 279010008844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010008845 active site 279010008846 phosphorylation site [posttranslational modification] 279010008847 intermolecular recognition site; other site 279010008848 dimerization interface [polypeptide binding]; other site 279010008849 LytTr DNA-binding domain; Region: LytTR; smart00850 279010008850 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 279010008851 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 279010008852 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 279010008853 Histidine kinase; Region: His_kinase; pfam06580 279010008854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010008855 ATP binding site [chemical binding]; other site 279010008856 Mg2+ binding site [ion binding]; other site 279010008857 G-X-G motif; other site 279010008858 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 279010008859 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 279010008860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010008861 motif II; other site 279010008862 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 279010008863 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279010008864 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 279010008865 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 279010008866 active site 279010008867 dimer interface [polypeptide binding]; other site 279010008868 motif 1; other site 279010008869 motif 2; other site 279010008870 motif 3; other site 279010008871 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 279010008872 anticodon binding site; other site 279010008873 YtxC-like family; Region: YtxC; pfam08812 279010008874 Uncharacterized conserved protein [Function unknown]; Region: COG0398 279010008875 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279010008876 primosomal protein DnaI; Reviewed; Region: PRK08939 279010008877 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 279010008878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008879 Walker A motif; other site 279010008880 ATP binding site [chemical binding]; other site 279010008881 Walker B motif; other site 279010008882 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 279010008883 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 279010008884 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 279010008885 ATP cone domain; Region: ATP-cone; pfam03477 279010008886 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 279010008887 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 279010008888 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 279010008889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 279010008890 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 279010008891 putative sugar binding sites [chemical binding]; other site 279010008892 Q-X-W motif; other site 279010008893 Pectate lyase; Region: Pec_lyase_C; cl01593 279010008894 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 279010008895 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 279010008896 CoA-binding site [chemical binding]; other site 279010008897 ATP-binding [chemical binding]; other site 279010008898 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 279010008899 Domain of unknown function DUF; Region: DUF204; pfam02659 279010008900 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 279010008901 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 279010008902 DNA binding site [nucleotide binding] 279010008903 catalytic residue [active] 279010008904 H2TH interface [polypeptide binding]; other site 279010008905 putative catalytic residues [active] 279010008906 turnover-facilitating residue; other site 279010008907 intercalation triad [nucleotide binding]; other site 279010008908 8OG recognition residue [nucleotide binding]; other site 279010008909 putative reading head residues; other site 279010008910 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 279010008911 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 279010008912 DNA polymerase I; Provisional; Region: PRK05755 279010008913 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 279010008914 active site 279010008915 metal binding site 1 [ion binding]; metal-binding site 279010008916 putative 5' ssDNA interaction site; other site 279010008917 metal binding site 3; metal-binding site 279010008918 metal binding site 2 [ion binding]; metal-binding site 279010008919 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 279010008920 putative DNA binding site [nucleotide binding]; other site 279010008921 putative metal binding site [ion binding]; other site 279010008922 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 279010008923 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 279010008924 active site 279010008925 DNA binding site [nucleotide binding] 279010008926 catalytic site [active] 279010008927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 279010008928 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010008929 PAS domain; Region: PAS; smart00091 279010008930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010008931 dimer interface [polypeptide binding]; other site 279010008932 phosphorylation site [posttranslational modification] 279010008933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010008934 ATP binding site [chemical binding]; other site 279010008935 Mg2+ binding site [ion binding]; other site 279010008936 G-X-G motif; other site 279010008937 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010008938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010008939 active site 279010008940 phosphorylation site [posttranslational modification] 279010008941 intermolecular recognition site; other site 279010008942 dimerization interface [polypeptide binding]; other site 279010008943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010008944 DNA binding site [nucleotide binding] 279010008945 malate dehydrogenase; Reviewed; Region: PRK06223 279010008946 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 279010008947 NAD(P) binding site [chemical binding]; other site 279010008948 dimer interface [polypeptide binding]; other site 279010008949 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010008950 substrate binding site [chemical binding]; other site 279010008951 isocitrate dehydrogenase; Reviewed; Region: PRK07006 279010008952 isocitrate dehydrogenase; Validated; Region: PRK07362 279010008953 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 279010008954 dimer interface [polypeptide binding]; other site 279010008955 Citrate synthase; Region: Citrate_synt; pfam00285 279010008956 active site 279010008957 citrylCoA binding site [chemical binding]; other site 279010008958 oxalacetate/citrate binding site [chemical binding]; other site 279010008959 coenzyme A binding site [chemical binding]; other site 279010008960 catalytic triad [active] 279010008961 Protein of unknown function (DUF441); Region: DUF441; pfam04284 279010008962 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 279010008963 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010008964 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 279010008965 pyruvate kinase; Provisional; Region: PRK06354 279010008966 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 279010008967 domain interfaces; other site 279010008968 active site 279010008969 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 279010008970 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 279010008971 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 279010008972 active site 279010008973 ADP/pyrophosphate binding site [chemical binding]; other site 279010008974 dimerization interface [polypeptide binding]; other site 279010008975 allosteric effector site; other site 279010008976 fructose-1,6-bisphosphate binding site; other site 279010008977 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 279010008978 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 279010008979 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 279010008980 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 279010008981 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 279010008982 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 279010008983 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010008984 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 279010008985 putative NAD(P) binding site [chemical binding]; other site 279010008986 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 279010008987 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 279010008988 active site 279010008989 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 279010008990 generic binding surface I; other site 279010008991 generic binding surface II; other site 279010008992 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 279010008993 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 279010008994 DHH family; Region: DHH; pfam01368 279010008995 DHHA1 domain; Region: DHHA1; pfam02272 279010008996 YtpI-like protein; Region: YtpI; pfam14007 279010008997 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 279010008998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010008999 DNA-binding site [nucleotide binding]; DNA binding site 279010009000 DRTGG domain; Region: DRTGG; pfam07085 279010009001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 279010009002 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 279010009003 active site 2 [active] 279010009004 active site 1 [active] 279010009005 Predicted transcriptional regulators [Transcription]; Region: COG1695 279010009006 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 279010009007 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 279010009008 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 279010009009 metal-dependent hydrolase; Provisional; Region: PRK00685 279010009010 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 279010009011 classical (c) SDRs; Region: SDR_c; cd05233 279010009012 NAD(P) binding site [chemical binding]; other site 279010009013 active site 279010009014 argininosuccinate lyase; Provisional; Region: PRK00855 279010009015 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 279010009016 active sites [active] 279010009017 tetramer interface [polypeptide binding]; other site 279010009018 argininosuccinate synthase; Provisional; Region: PRK13820 279010009019 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 279010009020 ANP binding site [chemical binding]; other site 279010009021 Substrate Binding Site II [chemical binding]; other site 279010009022 Substrate Binding Site I [chemical binding]; other site 279010009023 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 279010009024 MPT binding site; other site 279010009025 trimer interface [polypeptide binding]; other site 279010009026 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 279010009027 propionate/acetate kinase; Provisional; Region: PRK12379 279010009028 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 279010009029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010009030 S-adenosylmethionine binding site [chemical binding]; other site 279010009031 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 279010009032 dimer interface [polypeptide binding]; other site 279010009033 catalytic triad [active] 279010009034 peroxidatic and resolving cysteines [active] 279010009035 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 279010009036 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 279010009037 RDD family; Region: RDD; pfam06271 279010009038 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 279010009039 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 279010009040 tandem repeat interface [polypeptide binding]; other site 279010009041 oligomer interface [polypeptide binding]; other site 279010009042 active site residues [active] 279010009043 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 279010009044 ATP-NAD kinase; Region: NAD_kinase; pfam01513 279010009045 HlyD family secretion protein; Region: HlyD_3; pfam13437 279010009046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009047 putative substrate translocation pore; other site 279010009048 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010009049 MarR family; Region: MarR; pfam01047 279010009050 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 279010009051 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 279010009052 active site 279010009053 acyl-activating enzyme (AAE) consensus motif; other site 279010009054 putative CoA binding site [chemical binding]; other site 279010009055 AMP binding site [chemical binding]; other site 279010009056 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010009057 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 279010009058 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 279010009059 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 279010009060 Ligand Binding Site [chemical binding]; other site 279010009061 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 279010009062 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 279010009063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010009064 catalytic residue [active] 279010009065 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 279010009066 Homeodomain-like domain; Region: HTH_23; pfam13384 279010009067 Transposase; Region: HTH_Tnp_1; cl17663 279010009068 putative transposase OrfB; Reviewed; Region: PHA02517 279010009069 HTH-like domain; Region: HTH_21; pfam13276 279010009070 Integrase core domain; Region: rve; pfam00665 279010009071 Integrase core domain; Region: rve_3; pfam13683 279010009072 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 279010009073 histidinol-phosphatase; Reviewed; Region: PRK08123 279010009074 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 279010009075 active site 279010009076 dimer interface [polypeptide binding]; other site 279010009077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010009078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010009079 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 279010009080 GAF domain; Region: GAF_2; pfam13185 279010009081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 279010009082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010009083 metal binding site [ion binding]; metal-binding site 279010009084 active site 279010009085 I-site; other site 279010009086 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 279010009087 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 279010009088 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010009089 RNA binding surface [nucleotide binding]; other site 279010009090 Protein of unknown function (DUF805); Region: DUF805; pfam05656 279010009091 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 279010009092 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 279010009093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010009094 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 279010009095 putative DNA binding site [nucleotide binding]; other site 279010009096 putative Zn2+ binding site [ion binding]; other site 279010009097 AsnC family; Region: AsnC_trans_reg; pfam01037 279010009098 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 279010009099 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 279010009100 active site 279010009101 HIGH motif; other site 279010009102 dimer interface [polypeptide binding]; other site 279010009103 KMSKS motif; other site 279010009104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010009105 RNA binding surface [nucleotide binding]; other site 279010009106 acetyl-CoA synthetase; Provisional; Region: PRK04319 279010009107 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 279010009108 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 279010009109 active site 279010009110 acyl-activating enzyme (AAE) consensus motif; other site 279010009111 putative CoA binding site [chemical binding]; other site 279010009112 AMP binding site [chemical binding]; other site 279010009113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010009114 FOG: CBS domain [General function prediction only]; Region: COG0517 279010009115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 279010009116 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 279010009117 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 279010009118 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 279010009119 active site 279010009120 Zn binding site [ion binding]; other site 279010009121 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 279010009122 flagellar motor protein MotS; Reviewed; Region: PRK06925 279010009123 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 279010009124 ligand binding site [chemical binding]; other site 279010009125 flagellar motor protein MotP; Reviewed; Region: PRK06926 279010009126 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 279010009127 catabolite control protein A; Region: ccpA; TIGR01481 279010009128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010009129 DNA binding site [nucleotide binding] 279010009130 domain linker motif; other site 279010009131 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 279010009132 dimerization interface [polypeptide binding]; other site 279010009133 effector binding site; other site 279010009134 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 279010009135 Chorismate mutase type II; Region: CM_2; cl00693 279010009136 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 279010009137 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010009138 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 279010009139 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 279010009140 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 279010009141 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 279010009142 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279010009143 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010009144 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010009145 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 279010009146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010009147 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 279010009148 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 279010009149 putative tRNA-binding site [nucleotide binding]; other site 279010009150 hypothetical protein; Provisional; Region: PRK13668 279010009151 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010009152 catalytic residues [active] 279010009153 YtoQ family protein; Region: YtoQ_fam; TIGR03646 279010009154 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279010009155 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 279010009156 oligomer interface [polypeptide binding]; other site 279010009157 active site 279010009158 metal binding site [ion binding]; metal-binding site 279010009159 Predicted small secreted protein [Function unknown]; Region: COG5584 279010009160 malate dehydrogenase; Provisional; Region: PRK13529 279010009161 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010009162 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 279010009163 NAD(P) binding site [chemical binding]; other site 279010009164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279010009165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010009166 S-adenosylmethionine binding site [chemical binding]; other site 279010009167 YtzH-like protein; Region: YtzH; pfam14165 279010009168 Phosphotransferase enzyme family; Region: APH; pfam01636 279010009169 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 279010009170 active site 279010009171 substrate binding site [chemical binding]; other site 279010009172 ATP binding site [chemical binding]; other site 279010009173 pullulanase, type I; Region: pulA_typeI; TIGR02104 279010009174 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 279010009175 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 279010009176 Ca binding site [ion binding]; other site 279010009177 active site 279010009178 catalytic site [active] 279010009179 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 279010009180 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 279010009181 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 279010009182 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279010009183 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279010009184 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279010009185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279010009186 dimer interface [polypeptide binding]; other site 279010009187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009188 catalytic residue [active] 279010009189 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 279010009190 dipeptidase PepV; Reviewed; Region: PRK07318 279010009191 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 279010009192 active site 279010009193 metal binding site [ion binding]; metal-binding site 279010009194 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 279010009195 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 279010009196 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 279010009197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010009198 RNA binding surface [nucleotide binding]; other site 279010009199 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 279010009200 active site 279010009201 uracil binding [chemical binding]; other site 279010009202 stage V sporulation protein B; Region: spore_V_B; TIGR02900 279010009203 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 279010009204 HI0933-like protein; Region: HI0933_like; pfam03486 279010009205 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 279010009206 BCCT family transporter; Region: BCCT; pfam02028 279010009207 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 279010009208 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010009209 active site residue [active] 279010009210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010009211 TPR motif; other site 279010009212 binding surface 279010009213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009214 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009215 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009216 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 279010009217 Predicted integral membrane protein [Function unknown]; Region: COG5578 279010009218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010009219 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010009220 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 279010009221 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 279010009222 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010009223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009224 ABC-ATPase subunit interface; other site 279010009225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010009226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010009227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010009228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010009229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010009230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010009231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009232 dimer interface [polypeptide binding]; other site 279010009233 conserved gate region; other site 279010009234 putative PBP binding loops; other site 279010009235 ABC-ATPase subunit interface; other site 279010009236 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 279010009237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009238 NAD(P) binding site [chemical binding]; other site 279010009239 active site 279010009240 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 279010009241 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279010009242 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010009243 putative transporter; Provisional; Region: PRK11021 279010009244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010009245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010009246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010009247 dimerization interface [polypeptide binding]; other site 279010009248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010009249 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010009250 active site 279010009251 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 279010009252 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 279010009253 HIGH motif; other site 279010009254 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279010009255 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 279010009256 active site 279010009257 KMSKS motif; other site 279010009258 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 279010009259 tRNA binding surface [nucleotide binding]; other site 279010009260 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 279010009261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010009263 putative substrate translocation pore; other site 279010009264 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 279010009265 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 279010009266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 279010009267 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279010009268 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010009269 FtsX-like permease family; Region: FtsX; pfam02687 279010009270 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010009271 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279010009272 Walker A/P-loop; other site 279010009273 ATP binding site [chemical binding]; other site 279010009274 Q-loop/lid; other site 279010009275 ABC transporter signature motif; other site 279010009276 Walker B; other site 279010009277 D-loop; other site 279010009278 H-loop/switch region; other site 279010009279 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010009280 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010009281 Walker A/P-loop; other site 279010009282 ATP binding site [chemical binding]; other site 279010009283 Q-loop/lid; other site 279010009284 ABC transporter signature motif; other site 279010009285 Walker B; other site 279010009286 D-loop; other site 279010009287 H-loop/switch region; other site 279010009288 Predicted transcriptional regulators [Transcription]; Region: COG1725 279010009289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010009290 DNA-binding site [nucleotide binding]; DNA binding site 279010009291 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 279010009292 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 279010009293 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 279010009294 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010009295 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010009296 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 279010009297 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279010009298 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010009299 Serine hydrolase; Region: Ser_hydrolase; cl17834 279010009300 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 279010009301 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 279010009302 trimer interface [polypeptide binding]; other site 279010009303 putative metal binding site [ion binding]; other site 279010009304 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279010009305 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 279010009306 active site 279010009307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010009308 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 279010009309 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 279010009310 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 279010009311 active site 279010009312 dimer interface [polypeptide binding]; other site 279010009313 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 279010009314 Ligand Binding Site [chemical binding]; other site 279010009315 Molecular Tunnel; other site 279010009316 S-adenosylmethionine synthetase; Validated; Region: PRK05250 279010009317 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 279010009318 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 279010009319 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 279010009320 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 279010009321 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 279010009322 active site 279010009323 substrate-binding site [chemical binding]; other site 279010009324 metal-binding site [ion binding] 279010009325 ATP binding site [chemical binding]; other site 279010009326 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010009327 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 279010009328 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 279010009329 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 279010009330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010009331 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 279010009332 NMT1-like family; Region: NMT1_2; pfam13379 279010009333 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 279010009334 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 279010009335 Walker A/P-loop; other site 279010009336 ATP binding site [chemical binding]; other site 279010009337 Q-loop/lid; other site 279010009338 ABC transporter signature motif; other site 279010009339 Walker B; other site 279010009340 D-loop; other site 279010009341 H-loop/switch region; other site 279010009342 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 279010009343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009344 dimer interface [polypeptide binding]; other site 279010009345 conserved gate region; other site 279010009346 putative PBP binding loops; other site 279010009347 ABC-ATPase subunit interface; other site 279010009348 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 279010009349 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 279010009350 nudix motif; other site 279010009351 Holin family; Region: Phage_holin_4; cl01989 279010009352 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 279010009353 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 279010009354 dimerization interface [polypeptide binding]; other site 279010009355 DPS ferroxidase diiron center [ion binding]; other site 279010009356 ion pore; other site 279010009357 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 279010009358 YtkA-like; Region: YtkA; pfam13115 279010009359 S-ribosylhomocysteinase; Provisional; Region: PRK02260 279010009360 Haemolytic domain; Region: Haemolytic; pfam01809 279010009361 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 279010009362 active site clefts [active] 279010009363 zinc binding site [ion binding]; other site 279010009364 dimer interface [polypeptide binding]; other site 279010009365 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279010009366 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 279010009367 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 279010009368 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 279010009369 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010009370 intersubunit interface [polypeptide binding]; other site 279010009371 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 279010009372 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 279010009373 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 279010009374 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 279010009375 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 279010009376 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 279010009377 active site 279010009378 octamer interface [polypeptide binding]; other site 279010009379 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 279010009380 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 279010009381 acyl-activating enzyme (AAE) consensus motif; other site 279010009382 putative AMP binding site [chemical binding]; other site 279010009383 putative active site [active] 279010009384 putative CoA binding site [chemical binding]; other site 279010009385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010009386 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 279010009387 substrate binding site [chemical binding]; other site 279010009388 oxyanion hole (OAH) forming residues; other site 279010009389 trimer interface [polypeptide binding]; other site 279010009390 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 279010009391 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 279010009392 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 279010009393 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 279010009394 dimer interface [polypeptide binding]; other site 279010009395 tetramer interface [polypeptide binding]; other site 279010009396 PYR/PP interface [polypeptide binding]; other site 279010009397 TPP binding site [chemical binding]; other site 279010009398 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 279010009399 TPP-binding site; other site 279010009400 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 279010009401 isochorismate synthases; Region: isochor_syn; TIGR00543 279010009402 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 279010009403 UbiA prenyltransferase family; Region: UbiA; pfam01040 279010009404 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 279010009405 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 279010009406 homodimer interface [polypeptide binding]; other site 279010009407 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 279010009408 active site pocket [active] 279010009409 glycogen synthase; Provisional; Region: glgA; PRK00654 279010009410 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 279010009411 ADP-binding pocket [chemical binding]; other site 279010009412 homodimer interface [polypeptide binding]; other site 279010009413 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 279010009414 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 279010009415 ligand binding site; other site 279010009416 oligomer interface; other site 279010009417 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 279010009418 dimer interface [polypeptide binding]; other site 279010009419 N-terminal domain interface [polypeptide binding]; other site 279010009420 sulfate 1 binding site; other site 279010009421 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 279010009422 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 279010009423 ligand binding site; other site 279010009424 oligomer interface; other site 279010009425 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 279010009426 dimer interface [polypeptide binding]; other site 279010009427 N-terminal domain interface [polypeptide binding]; other site 279010009428 sulfate 1 binding site; other site 279010009429 glycogen branching enzyme; Provisional; Region: PRK12313 279010009430 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 279010009431 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 279010009432 active site 279010009433 catalytic site [active] 279010009434 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 279010009435 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010009436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010009437 DNA-binding site [nucleotide binding]; DNA binding site 279010009438 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 279010009439 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 279010009440 putative dimerization interface [polypeptide binding]; other site 279010009441 putative ligand binding site [chemical binding]; other site 279010009442 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 279010009443 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 279010009444 active site 279010009445 catalytic site [active] 279010009446 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009447 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 279010009448 putative substrate binding pocket [chemical binding]; other site 279010009449 AC domain interface; other site 279010009450 catalytic triad [active] 279010009451 AB domain interface; other site 279010009452 interchain disulfide; other site 279010009453 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279010009454 TrkA-N domain; Region: TrkA_N; pfam02254 279010009455 TrkA-C domain; Region: TrkA_C; pfam02080 279010009456 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 279010009457 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279010009458 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010009459 EamA-like transporter family; Region: EamA; pfam00892 279010009460 DinB superfamily; Region: DinB_2; pfam12867 279010009461 metal-dependent hydrolase; Provisional; Region: PRK13291 279010009462 MOSC domain; Region: MOSC; pfam03473 279010009463 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 279010009464 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 279010009465 active site 279010009466 NAD binding site [chemical binding]; other site 279010009467 metal binding site [ion binding]; metal-binding site 279010009468 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 279010009469 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 279010009470 tetramerization interface [polypeptide binding]; other site 279010009471 NAD(P) binding site [chemical binding]; other site 279010009472 catalytic residues [active] 279010009473 Predicted transcriptional regulators [Transcription]; Region: COG1510 279010009474 MarR family; Region: MarR_2; pfam12802 279010009475 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 279010009476 Na binding site [ion binding]; other site 279010009477 putative glycosylation site [posttranslational modification]; other site 279010009478 putative glycosylation site [posttranslational modification]; other site 279010009479 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 279010009480 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 279010009481 alanine racemase; Region: alr; TIGR00492 279010009482 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 279010009483 active site 279010009484 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010009485 dimer interface [polypeptide binding]; other site 279010009486 substrate binding site [chemical binding]; other site 279010009487 catalytic residues [active] 279010009488 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 279010009489 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 279010009490 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 279010009491 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 279010009492 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 279010009493 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 279010009494 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010009495 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 279010009496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010009497 putative active site [active] 279010009498 putative metal binding site [ion binding]; other site 279010009499 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 279010009500 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010009501 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 279010009502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010009503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010009504 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279010009505 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 279010009506 proposed catalytic triad [active] 279010009507 conserved cys residue [active] 279010009508 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010009509 Cache domain; Region: Cache_1; pfam02743 279010009510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009511 dimerization interface [polypeptide binding]; other site 279010009512 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010009513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009514 dimer interface [polypeptide binding]; other site 279010009515 putative CheW interface [polypeptide binding]; other site 279010009516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009517 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010009518 Cache domain; Region: Cache_1; pfam02743 279010009519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009520 dimerization interface [polypeptide binding]; other site 279010009521 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010009522 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009523 dimer interface [polypeptide binding]; other site 279010009524 putative CheW interface [polypeptide binding]; other site 279010009525 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010009526 Cache domain; Region: Cache_1; pfam02743 279010009527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009528 dimerization interface [polypeptide binding]; other site 279010009529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010009530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009531 dimer interface [polypeptide binding]; other site 279010009532 putative CheW interface [polypeptide binding]; other site 279010009533 transglutaminase; Provisional; Region: tgl; PRK03187 279010009534 Nitronate monooxygenase; Region: NMO; pfam03060 279010009535 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 279010009536 FMN binding site [chemical binding]; other site 279010009537 substrate binding site [chemical binding]; other site 279010009538 putative catalytic residue [active] 279010009539 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 279010009540 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279010009541 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279010009542 Ca binding site [ion binding]; other site 279010009543 active site 279010009544 catalytic site [active] 279010009545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010009546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010009547 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 279010009548 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010009549 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010009550 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010009551 Transporter associated domain; Region: CorC_HlyC; smart01091 279010009552 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 279010009553 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 279010009554 Ion channel; Region: Ion_trans_2; pfam07885 279010009555 TrkA-N domain; Region: TrkA_N; pfam02254 279010009556 Calcium-activated BK potassium channel alpha subunit; Region: BK_channel_a; pfam03493 279010009557 YugN-like family; Region: YugN; pfam08868 279010009558 Predicted membrane protein [Function unknown]; Region: COG2323 279010009559 TspO/MBR family; Region: TspO_MBR; pfam03073 279010009560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010009561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010009562 Coenzyme A binding pocket [chemical binding]; other site 279010009563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010009564 H-loop/switch region; other site 279010009565 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 279010009566 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 279010009567 active site 279010009568 dimer interface [polypeptide binding]; other site 279010009569 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 279010009570 dimer interface [polypeptide binding]; other site 279010009571 active site 279010009572 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 279010009573 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 279010009574 dimer interface [polypeptide binding]; other site 279010009575 active site 279010009576 metal binding site [ion binding]; metal-binding site 279010009577 Uncharacterized conserved protein [Function unknown]; Region: COG2155 279010009578 general stress protein 13; Validated; Region: PRK08059 279010009579 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 279010009580 RNA binding site [nucleotide binding]; other site 279010009581 hypothetical protein; Validated; Region: PRK07682 279010009582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010009583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009584 homodimer interface [polypeptide binding]; other site 279010009585 catalytic residue [active] 279010009586 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 279010009587 AsnC family; Region: AsnC_trans_reg; pfam01037 279010009588 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 279010009589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010009590 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 279010009591 nucleophilic elbow; other site 279010009592 catalytic site [active] 279010009593 catalytic triad; other site 279010009594 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 279010009595 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 279010009596 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010009597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009598 homodimer interface [polypeptide binding]; other site 279010009599 catalytic residue [active] 279010009600 Kinase associated protein B; Region: KapB; pfam08810 279010009601 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 279010009602 active site 279010009603 catalytic site [active] 279010009604 substrate binding site [chemical binding]; other site 279010009605 drug efflux system protein MdtG; Provisional; Region: PRK09874 279010009606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009607 putative substrate translocation pore; other site 279010009608 Transglycosylase; Region: Transgly; pfam00912 279010009609 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010009610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 279010009611 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 279010009612 sensory histidine kinase DcuS; Provisional; Region: PRK11086 279010009613 PAS domain; Region: PAS; smart00091 279010009614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010009615 ATP binding site [chemical binding]; other site 279010009616 Mg2+ binding site [ion binding]; other site 279010009617 G-X-G motif; other site 279010009618 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 279010009619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009620 active site 279010009621 phosphorylation site [posttranslational modification] 279010009622 intermolecular recognition site; other site 279010009623 dimerization interface [polypeptide binding]; other site 279010009624 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 279010009625 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 279010009626 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 279010009627 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279010009628 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 279010009629 Transposase; Region: HTH_Tnp_1; cl17663 279010009630 putative transposase OrfB; Reviewed; Region: PHA02517 279010009631 HTH-like domain; Region: HTH_21; pfam13276 279010009632 Integrase core domain; Region: rve; pfam00665 279010009633 Integrase core domain; Region: rve_3; pfam13683 279010009634 Homeodomain-like domain; Region: HTH_23; pfam13384 279010009635 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 279010009636 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 279010009637 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279010009638 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 279010009639 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 279010009640 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 279010009641 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 279010009642 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279010009643 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 279010009644 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 279010009645 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 279010009646 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 279010009647 CoenzymeA binding site [chemical binding]; other site 279010009648 subunit interaction site [polypeptide binding]; other site 279010009649 PHB binding site; other site 279010009650 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010009651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009652 active site 279010009653 phosphorylation site [posttranslational modification] 279010009654 intermolecular recognition site; other site 279010009655 dimerization interface [polypeptide binding]; other site 279010009656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010009657 DNA binding residues [nucleotide binding] 279010009658 dimerization interface [polypeptide binding]; other site 279010009659 Transposase; Region: HTH_Tnp_1; cl17663 279010009660 putative transposase OrfB; Reviewed; Region: PHA02517 279010009661 HTH-like domain; Region: HTH_21; pfam13276 279010009662 Integrase core domain; Region: rve; pfam00665 279010009663 Integrase core domain; Region: rve_3; pfam13683 279010009664 Homeodomain-like domain; Region: HTH_23; pfam13384 279010009665 Bacillus competence pheromone ComX; Region: ComX; pfam05952 279010009666 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 279010009667 substrate binding pocket [chemical binding]; other site 279010009668 aspartate-rich region 2; other site 279010009669 substrate-Mg2+ binding site; other site 279010009670 DegQ (SacQ) family; Region: DegQ; pfam08181 279010009671 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 279010009672 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 279010009673 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 279010009674 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 279010009675 active site 279010009676 Isochorismatase family; Region: Isochorismatase; pfam00857 279010009677 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 279010009678 catalytic triad [active] 279010009679 conserved cis-peptide bond; other site 279010009680 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 279010009681 YueH-like protein; Region: YueH; pfam14166 279010009682 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010009683 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 279010009684 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010009685 Rrf2 family protein; Region: rrf2_super; TIGR00738 279010009686 Transcriptional regulator; Region: Rrf2; pfam02082 279010009687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010009688 PGAP1-like protein; Region: PGAP1; pfam07819 279010009689 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 279010009690 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010009691 Zn2+ binding site [ion binding]; other site 279010009692 Mg2+ binding site [ion binding]; other site 279010009693 short chain dehydrogenase; Provisional; Region: PRK06924 279010009694 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 279010009695 NADP binding site [chemical binding]; other site 279010009696 homodimer interface [polypeptide binding]; other site 279010009697 active site 279010009698 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 279010009699 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279010009700 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 279010009701 Predicted membrane protein [Function unknown]; Region: COG1511 279010009702 Haemolysin XhlA; Region: XhlA; pfam10779 279010009703 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 279010009704 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 279010009705 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 279010009706 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 279010009707 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 279010009708 Domain of unknown function DUF87; Region: DUF87; pfam01935 279010009709 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 279010009710 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 279010009711 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 279010009712 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 279010009713 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010009714 amino acid carrier protein; Region: agcS; TIGR00835 279010009715 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010009716 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 279010009717 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 279010009718 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 279010009719 hexamer interface [polypeptide binding]; other site 279010009720 ligand binding site [chemical binding]; other site 279010009721 putative active site [active] 279010009722 NAD(P) binding site [chemical binding]; other site 279010009723 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 279010009724 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 279010009725 Moco binding site; other site 279010009726 metal coordination site [ion binding]; other site 279010009727 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 279010009728 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 279010009729 Predicted permease [General function prediction only]; Region: COG2056 279010009730 multifunctional aminopeptidase A; Provisional; Region: PRK00913 279010009731 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 279010009732 interface (dimer of trimers) [polypeptide binding]; other site 279010009733 Substrate-binding/catalytic site; other site 279010009734 Zn-binding sites [ion binding]; other site 279010009735 Divergent PAP2 family; Region: DUF212; pfam02681 279010009736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 279010009737 Putative membrane protein; Region: YuiB; pfam14068 279010009738 chaperone protein DnaJ; Provisional; Region: PRK14291 279010009739 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279010009740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010009741 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279010009742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010009743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010009744 Cold-inducible protein YdjO; Region: YdjO; pfam14169 279010009745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279010009746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010009747 Coenzyme A binding pocket [chemical binding]; other site 279010009748 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 279010009749 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 279010009750 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 279010009751 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 279010009752 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 279010009753 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279010009754 Nucleoside recognition; Region: Gate; pfam07670 279010009755 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279010009756 hypothetical protein; Provisional; Region: PRK13669 279010009757 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279010009758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010009759 Uncharacterized conserved protein [Function unknown]; Region: COG5646 279010009760 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009761 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 279010009762 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 279010009763 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 279010009764 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 279010009765 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 279010009766 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 279010009767 structural tetrad; other site 279010009768 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279010009769 homoserine kinase; Provisional; Region: PRK01212 279010009770 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279010009771 threonine synthase; Reviewed; Region: PRK06721 279010009772 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 279010009773 homodimer interface [polypeptide binding]; other site 279010009774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009775 catalytic residue [active] 279010009776 homoserine dehydrogenase; Provisional; Region: PRK06349 279010009777 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 279010009778 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 279010009779 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 279010009780 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 279010009781 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 279010009782 dimerization interface [polypeptide binding]; other site 279010009783 ligand binding site [chemical binding]; other site 279010009784 NADP binding site [chemical binding]; other site 279010009785 catalytic site [active] 279010009786 spore coat protein YutH; Region: spore_yutH; TIGR02905 279010009787 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 279010009788 tetramer interfaces [polypeptide binding]; other site 279010009789 binuclear metal-binding site [ion binding]; other site 279010009790 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 279010009791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010009792 active site 279010009793 motif I; other site 279010009794 motif II; other site 279010009795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010009796 Uncharacterized conserved protein [Function unknown]; Region: COG2445 279010009797 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 279010009798 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010009799 lipoyl synthase; Provisional; Region: PRK05481 279010009800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010009801 FeS/SAM binding site; other site 279010009802 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279010009803 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010009804 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 279010009805 Na2 binding site [ion binding]; other site 279010009806 putative substrate binding site 1 [chemical binding]; other site 279010009807 Na binding site 1 [ion binding]; other site 279010009808 putative substrate binding site 2 [chemical binding]; other site 279010009809 sporulation protein YunB; Region: spo_yunB; TIGR02832 279010009810 Uncharacterized conserved protein [Function unknown]; Region: COG3377 279010009811 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279010009812 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 279010009813 active site 279010009814 metal binding site [ion binding]; metal-binding site 279010009815 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010009816 Predicted permeases [General function prediction only]; Region: COG0730 279010009817 Uncharacterized conserved protein [Function unknown]; Region: COG1801 279010009818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010009819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010009820 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 279010009821 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 279010009822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010009823 catalytic residue [active] 279010009824 allantoate amidohydrolase; Reviewed; Region: PRK12893 279010009825 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 279010009826 active site 279010009827 metal binding site [ion binding]; metal-binding site 279010009828 dimer interface [polypeptide binding]; other site 279010009829 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 279010009830 DRTGG domain; Region: DRTGG; pfam07085 279010009831 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010009832 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 279010009833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010009835 putative substrate translocation pore; other site 279010009836 Predicted membrane protein [Function unknown]; Region: COG1288 279010009837 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 279010009838 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279010009839 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010009840 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010009841 Endonuclease I; Region: Endonuclease_1; pfam04231 279010009842 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 279010009843 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 279010009844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279010009845 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 279010009846 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 279010009847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009848 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 279010009849 FeS assembly protein SufB; Region: sufB; TIGR01980 279010009850 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 279010009851 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 279010009852 trimerization site [polypeptide binding]; other site 279010009853 active site 279010009854 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 279010009855 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 279010009856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010009857 catalytic residue [active] 279010009858 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 279010009859 FeS assembly protein SufD; Region: sufD; TIGR01981 279010009860 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 279010009861 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 279010009862 Walker A/P-loop; other site 279010009863 ATP binding site [chemical binding]; other site 279010009864 Q-loop/lid; other site 279010009865 ABC transporter signature motif; other site 279010009866 Walker B; other site 279010009867 D-loop; other site 279010009868 H-loop/switch region; other site 279010009869 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 279010009870 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 279010009871 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 279010009872 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 279010009873 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 279010009874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009875 dimer interface [polypeptide binding]; other site 279010009876 conserved gate region; other site 279010009877 putative PBP binding loops; other site 279010009878 ABC-ATPase subunit interface; other site 279010009879 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 279010009880 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 279010009881 Walker A/P-loop; other site 279010009882 ATP binding site [chemical binding]; other site 279010009883 Q-loop/lid; other site 279010009884 ABC transporter signature motif; other site 279010009885 Walker B; other site 279010009886 D-loop; other site 279010009887 H-loop/switch region; other site 279010009888 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 279010009889 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010009890 catalytic residues [active] 279010009891 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 279010009892 putative active site [active] 279010009893 putative metal binding site [ion binding]; other site 279010009894 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 279010009895 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 279010009896 lipoyl attachment site [posttranslational modification]; other site 279010009897 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 279010009898 ArsC family; Region: ArsC; pfam03960 279010009899 putative ArsC-like catalytic residues; other site 279010009900 putative TRX-like catalytic residues [active] 279010009901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 279010009902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010009903 active site 279010009904 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 279010009905 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 279010009906 dimer interface [polypeptide binding]; other site 279010009907 active site 279010009908 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 279010009909 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 279010009910 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 279010009911 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 279010009912 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 279010009913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010009914 substrate binding site [chemical binding]; other site 279010009915 oxyanion hole (OAH) forming residues; other site 279010009916 trimer interface [polypeptide binding]; other site 279010009917 YuzL-like protein; Region: YuzL; pfam14115 279010009918 Coat F domain; Region: Coat_F; pfam07875 279010009919 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 279010009920 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 279010009921 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279010009922 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 279010009923 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010009924 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010009925 Walker A/P-loop; other site 279010009926 ATP binding site [chemical binding]; other site 279010009927 Q-loop/lid; other site 279010009928 ABC transporter signature motif; other site 279010009929 Walker B; other site 279010009930 D-loop; other site 279010009931 H-loop/switch region; other site 279010009932 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010009933 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009934 ABC-ATPase subunit interface; other site 279010009935 dimer interface [polypeptide binding]; other site 279010009936 putative PBP binding regions; other site 279010009937 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010009938 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009939 ABC-ATPase subunit interface; other site 279010009940 dimer interface [polypeptide binding]; other site 279010009941 putative PBP binding regions; other site 279010009942 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010009943 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279010009944 siderophore binding site; other site 279010009945 YusW-like protein; Region: YusW; pfam14039 279010009946 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 279010009947 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 279010009948 active site 279010009949 Zn binding site [ion binding]; other site 279010009950 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 279010009951 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 279010009952 short chain dehydrogenase; Provisional; Region: PRK06914 279010009953 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 279010009954 NADP binding site [chemical binding]; other site 279010009955 active site 279010009956 steroid binding site; other site 279010009957 Ferritin-like domain; Region: Ferritin; pfam00210 279010009958 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 279010009959 dimerization interface [polypeptide binding]; other site 279010009960 DPS ferroxidase diiron center [ion binding]; other site 279010009961 ion pore; other site 279010009962 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279010009963 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010009964 protein binding site [polypeptide binding]; other site 279010009965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010009966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009967 active site 279010009968 phosphorylation site [posttranslational modification] 279010009969 intermolecular recognition site; other site 279010009970 dimerization interface [polypeptide binding]; other site 279010009971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010009972 DNA binding site [nucleotide binding] 279010009973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010009974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009975 dimerization interface [polypeptide binding]; other site 279010009976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010009977 dimer interface [polypeptide binding]; other site 279010009978 phosphorylation site [posttranslational modification] 279010009979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010009980 ATP binding site [chemical binding]; other site 279010009981 Mg2+ binding site [ion binding]; other site 279010009982 G-X-G motif; other site 279010009983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010009984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279010009985 fumarate hydratase; Reviewed; Region: fumC; PRK00485 279010009986 Class II fumarases; Region: Fumarase_classII; cd01362 279010009987 active site 279010009988 tetramer interface [polypeptide binding]; other site 279010009989 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 279010009990 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010009991 Spore germination protein; Region: Spore_permease; cl17796 279010009992 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 279010009993 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 279010009994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010009995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009996 active site 279010009997 phosphorylation site [posttranslational modification] 279010009998 intermolecular recognition site; other site 279010009999 dimerization interface [polypeptide binding]; other site 279010010000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010010001 DNA binding residues [nucleotide binding] 279010010002 dimerization interface [polypeptide binding]; other site 279010010003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010010004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010010005 dimerization interface [polypeptide binding]; other site 279010010006 Histidine kinase; Region: HisKA_3; pfam07730 279010010007 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 279010010008 ATP binding site [chemical binding]; other site 279010010009 Mg2+ binding site [ion binding]; other site 279010010010 G-X-G motif; other site 279010010011 Predicted membrane protein [Function unknown]; Region: COG4758 279010010012 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 279010010013 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 279010010014 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279010010015 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279010010016 PspA/IM30 family; Region: PspA_IM30; pfam04012 279010010017 Interleukin 10; Region: IL10; cl02501 279010010018 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 279010010019 putative pectinesterase; Region: PLN02432; cl01911 279010010020 Pectinesterase; Region: Pectinesterase; pfam01095 279010010021 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 279010010022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010010023 classical (c) SDRs; Region: SDR_c; cd05233 279010010024 NAD(P) binding site [chemical binding]; other site 279010010025 active site 279010010026 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 279010010027 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 279010010028 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 279010010029 putative active site [active] 279010010030 metal binding site [ion binding]; metal-binding site 279010010031 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279010010032 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 279010010033 inhibitor site; inhibition site 279010010034 active site 279010010035 dimer interface [polypeptide binding]; other site 279010010036 catalytic residue [active] 279010010037 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010010038 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010010039 Walker A/P-loop; other site 279010010040 ATP binding site [chemical binding]; other site 279010010041 Q-loop/lid; other site 279010010042 ABC transporter signature motif; other site 279010010043 Walker B; other site 279010010044 D-loop; other site 279010010045 H-loop/switch region; other site 279010010046 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 279010010047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010010048 ABC-ATPase subunit interface; other site 279010010049 dimer interface [polypeptide binding]; other site 279010010050 putative PBP binding regions; other site 279010010051 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279010010052 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 279010010053 putative binding site residues; other site 279010010054 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010010055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010010056 DNA-binding site [nucleotide binding]; DNA binding site 279010010057 FCD domain; Region: FCD; pfam07729 279010010058 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010010059 classical (c) SDRs; Region: SDR_c; cd05233 279010010060 NAD(P) binding site [chemical binding]; other site 279010010061 active site 279010010062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 279010010063 MOSC domain; Region: MOSC; pfam03473 279010010064 3-alpha domain; Region: 3-alpha; pfam03475 279010010065 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 279010010066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010010067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010010068 dimerization interface [polypeptide binding]; other site 279010010069 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 279010010070 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 279010010071 galactarate dehydratase; Region: galactar-dH20; TIGR03248 279010010072 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 279010010073 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 279010010074 altronate oxidoreductase; Provisional; Region: PRK03643 279010010075 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 279010010076 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 279010010077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010010078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010010079 DNA binding site [nucleotide binding] 279010010080 domain linker motif; other site 279010010081 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279010010082 dimerization interface [polypeptide binding]; other site 279010010083 ligand binding site [chemical binding]; other site 279010010084 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 279010010085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010086 putative substrate translocation pore; other site 279010010087 Glucuronate isomerase; Region: UxaC; pfam02614 279010010088 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 279010010089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010010090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010010091 dimer interface [polypeptide binding]; other site 279010010092 phosphorylation site [posttranslational modification] 279010010093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010010094 ATP binding site [chemical binding]; other site 279010010095 Mg2+ binding site [ion binding]; other site 279010010096 G-X-G motif; other site 279010010097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010010098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010010099 active site 279010010100 phosphorylation site [posttranslational modification] 279010010101 intermolecular recognition site; other site 279010010102 dimerization interface [polypeptide binding]; other site 279010010103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010010104 DNA binding site [nucleotide binding] 279010010105 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010010106 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010010107 Walker A/P-loop; other site 279010010108 ATP binding site [chemical binding]; other site 279010010109 Q-loop/lid; other site 279010010110 ABC transporter signature motif; other site 279010010111 Walker B; other site 279010010112 D-loop; other site 279010010113 H-loop/switch region; other site 279010010114 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 279010010115 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010010116 ABC-ATPase subunit interface; other site 279010010117 dimer interface [polypeptide binding]; other site 279010010118 putative PBP binding regions; other site 279010010119 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010010120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010010121 ABC-ATPase subunit interface; other site 279010010122 dimer interface [polypeptide binding]; other site 279010010123 putative PBP binding regions; other site 279010010124 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 279010010125 Spore germination protein; Region: Spore_permease; cl17796 279010010126 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 279010010127 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 279010010128 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010010129 Sulfatase; Region: Sulfatase; pfam00884 279010010130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010010132 putative substrate translocation pore; other site 279010010133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010134 putative substrate translocation pore; other site 279010010135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010010136 active site 279010010137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010010138 catalytic tetrad [active] 279010010139 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279010010140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010010141 nucleotide binding site [chemical binding]; other site 279010010142 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 279010010143 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010010144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010010145 catalytic residue [active] 279010010146 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 279010010147 Family description; Region: UvrD_C_2; pfam13538 279010010148 Predicted membrane protein [Function unknown]; Region: COG2860 279010010149 UPF0126 domain; Region: UPF0126; pfam03458 279010010150 UPF0126 domain; Region: UPF0126; pfam03458 279010010151 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 279010010152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279010010153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010010154 Coenzyme A binding pocket [chemical binding]; other site 279010010155 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 279010010156 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 279010010157 Thioredoxin; Region: Thioredoxin_4; pfam13462 279010010158 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279010010159 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010010160 metal-binding site [ion binding] 279010010161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010010162 Soluble P-type ATPase [General function prediction only]; Region: COG4087 279010010163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010010164 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 279010010165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010010166 dimer interface [polypeptide binding]; other site 279010010167 conserved gate region; other site 279010010168 putative PBP binding loops; other site 279010010169 ABC-ATPase subunit interface; other site 279010010170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010010171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010010172 dimer interface [polypeptide binding]; other site 279010010173 conserved gate region; other site 279010010174 putative PBP binding loops; other site 279010010175 ABC-ATPase subunit interface; other site 279010010176 putative alpha-glucosidase; Provisional; Region: PRK10658 279010010177 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 279010010178 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 279010010179 active site 279010010180 homotrimer interface [polypeptide binding]; other site 279010010181 catalytic site [active] 279010010182 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 279010010183 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 279010010184 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 279010010185 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 279010010186 PKC phosphorylation site [posttranslational modification]; other site 279010010187 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 279010010188 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 279010010189 metal binding site [ion binding]; metal-binding site 279010010190 ligand binding site [chemical binding]; other site 279010010191 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279010010192 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 279010010193 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 279010010194 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010010195 dimer interface [polypeptide binding]; other site 279010010196 ABC-ATPase subunit interface; other site 279010010197 putative PBP binding regions; other site 279010010198 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 279010010199 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 279010010200 metal binding site [ion binding]; metal-binding site 279010010201 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 279010010202 dimerization interface [polypeptide binding]; other site 279010010203 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010010204 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279010010205 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279010010206 putative active site [active] 279010010207 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 279010010208 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 279010010209 putative substrate binding site [chemical binding]; other site 279010010210 putative ATP binding site [chemical binding]; other site 279010010211 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 279010010212 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279010010213 active site 279010010214 P-loop; other site 279010010215 phosphorylation site [posttranslational modification] 279010010216 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 279010010217 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010010218 active site 279010010219 phosphorylation site [posttranslational modification] 279010010220 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279010010221 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 279010010222 intersubunit interface [polypeptide binding]; other site 279010010223 active site 279010010224 zinc binding site [ion binding]; other site 279010010225 Na+ binding site [ion binding]; other site 279010010226 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279010010227 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010010228 metal-binding site [ion binding] 279010010229 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279010010230 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010010231 metal-binding site [ion binding] 279010010232 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010010233 Soluble P-type ATPase [General function prediction only]; Region: COG4087 279010010234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279010010235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010010236 metal-binding site [ion binding] 279010010237 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 279010010238 putative homodimer interface [polypeptide binding]; other site 279010010239 putative homotetramer interface [polypeptide binding]; other site 279010010240 allosteric switch controlling residues; other site 279010010241 putative metal binding site [ion binding]; other site 279010010242 putative homodimer-homodimer interface [polypeptide binding]; other site 279010010243 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279010010244 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 279010010245 conserved cys residue [active] 279010010246 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010010247 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 279010010248 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 279010010249 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 279010010250 N- and C-terminal domain interface [polypeptide binding]; other site 279010010251 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 279010010252 active site 279010010253 putative catalytic site [active] 279010010254 metal binding site [ion binding]; metal-binding site 279010010255 ATP binding site [chemical binding]; other site 279010010256 carbohydrate binding site [chemical binding]; other site 279010010257 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 279010010258 L-rhamnose isomerase, Streptomyces subtype; Region: RhaI_grampos; TIGR02635 279010010259 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 279010010260 short chain dehydrogenase; Validated; Region: PRK08324 279010010261 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 279010010262 intersubunit interface [polypeptide binding]; other site 279010010263 active site 279010010264 Zn2+ binding site [ion binding]; other site 279010010265 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 279010010266 putative NAD(P) binding site [chemical binding]; other site 279010010267 active site 279010010268 MFS transport protein AraJ; Provisional; Region: PRK10091 279010010269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010270 putative substrate translocation pore; other site 279010010271 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010010272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010273 putative substrate translocation pore; other site 279010010274 Cytochrome P450; Region: p450; cl12078 279010010275 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279010010276 SnoaL-like domain; Region: SnoaL_2; pfam12680 279010010277 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010010278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010010279 putative DNA binding site [nucleotide binding]; other site 279010010280 dimerization interface [polypeptide binding]; other site 279010010281 putative Zn2+ binding site [ion binding]; other site 279010010282 putative oxidoreductase; Provisional; Region: PRK11579 279010010283 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010010284 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 279010010285 azoreductase; Reviewed; Region: PRK00170 279010010286 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010010287 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 279010010288 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 279010010289 active site residue [active] 279010010290 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 279010010291 hypothetical protein; Provisional; Region: PRK14082 279010010292 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279010010293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010010294 DNA binding residues [nucleotide binding] 279010010295 YvrJ protein family; Region: YvrJ; pfam12841 279010010296 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 279010010297 Cupin; Region: Cupin_1; smart00835 279010010298 Cupin; Region: Cupin_1; smart00835 279010010299 Regulatory protein YrvL; Region: YrvL; pfam14184 279010010300 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 279010010301 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010010302 prophage region BLi_Pp6 279010010303 Transposase; Region: HTH_Tnp_1; cl17663 279010010304 putative transposase OrfB; Reviewed; Region: PHA02517 279010010305 HTH-like domain; Region: HTH_21; pfam13276 279010010306 Integrase core domain; Region: rve; pfam00665 279010010307 Integrase core domain; Region: rve_3; pfam13683 279010010308 Homeodomain-like domain; Region: HTH_23; pfam13384 279010010309 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 279010010310 Helix-turn-helix domain; Region: HTH_17; pfam12728 279010010311 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010010312 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010010313 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279010010314 amidase catalytic site [active] 279010010315 Zn binding residues [ion binding]; other site 279010010316 substrate binding site [chemical binding]; other site 279010010317 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 279010010318 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010010319 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010010320 holin, SPP1 family; Region: holin_SPP1; TIGR01592 279010010321 Haemolysin XhlA; Region: XhlA; pfam10779 279010010322 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 279010010323 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279010010324 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 279010010325 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 279010010326 Phage tail protein; Region: Sipho_tail; pfam05709 279010010327 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 279010010328 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279010010329 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010010330 catalytic residue [active] 279010010331 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 279010010332 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 279010010333 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 279010010334 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 279010010335 oligomerization interface [polypeptide binding]; other site 279010010336 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 279010010337 Phage capsid family; Region: Phage_capsid; pfam05065 279010010338 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 279010010339 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 279010010340 oligomer interface [polypeptide binding]; other site 279010010341 active site residues [active] 279010010342 Phage portal protein; Region: Phage_portal; pfam04860 279010010343 Phage-related protein [Function unknown]; Region: COG4695 279010010344 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 279010010345 Phage terminase, small subunit; Region: Terminase_4; pfam05119 279010010346 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 279010010347 HNH endonuclease; Region: HNH; pfam01844 279010010348 active site 279010010349 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 279010010350 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 279010010351 ERCC4 domain; Region: ERCC4; pfam02732 279010010352 Uncharacterized conserved protein [Function unknown]; Region: COG4983 279010010353 D5 N terminal like; Region: D5_N; pfam08706 279010010354 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 279010010355 Protein of unknown function (DUF669); Region: DUF669; pfam05037 279010010356 AAA domain; Region: AAA_25; pfam13481 279010010357 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 279010010358 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 279010010359 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 279010010360 ORF6N domain; Region: ORF6N; pfam10543 279010010361 Predicted transcriptional regulator [Transcription]; Region: COG2932 279010010362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010010363 non-specific DNA binding site [nucleotide binding]; other site 279010010364 salt bridge; other site 279010010365 sequence-specific DNA binding site [nucleotide binding]; other site 279010010366 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 279010010367 Catalytic site [active] 279010010368 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010010369 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 279010010370 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279010010371 Int/Topo IB signature motif; other site 279010010372 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 279010010373 SmpB-tmRNA interface; other site 279010010374 ribonuclease R; Region: RNase_R; TIGR02063 279010010375 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 279010010376 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 279010010377 RNB domain; Region: RNB; pfam00773 279010010378 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 279010010379 RNA binding site [nucleotide binding]; other site 279010010380 Esterase/lipase [General function prediction only]; Region: COG1647 279010010381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279010010382 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 279010010383 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 279010010384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010010385 salt bridge; other site 279010010386 non-specific DNA binding site [nucleotide binding]; other site 279010010387 sequence-specific DNA binding site [nucleotide binding]; other site 279010010388 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010010389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010010390 non-specific DNA binding site [nucleotide binding]; other site 279010010391 salt bridge; other site 279010010392 sequence-specific DNA binding site [nucleotide binding]; other site 279010010393 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010010394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010010395 non-specific DNA binding site [nucleotide binding]; other site 279010010396 salt bridge; other site 279010010397 sequence-specific DNA binding site [nucleotide binding]; other site 279010010398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010010399 dimer interface [polypeptide binding]; other site 279010010400 conserved gate region; other site 279010010401 putative PBP binding loops; other site 279010010402 ABC-ATPase subunit interface; other site 279010010403 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 279010010404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010010405 dimer interface [polypeptide binding]; other site 279010010406 conserved gate region; other site 279010010407 ABC-ATPase subunit interface; other site 279010010408 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 279010010409 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 279010010410 Walker A/P-loop; other site 279010010411 ATP binding site [chemical binding]; other site 279010010412 Q-loop/lid; other site 279010010413 ABC transporter signature motif; other site 279010010414 Walker B; other site 279010010415 D-loop; other site 279010010416 H-loop/switch region; other site 279010010417 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 279010010418 Predicted transcriptional regulators [Transcription]; Region: COG1510 279010010419 MarR family; Region: MarR_2; pfam12802 279010010420 MarC family integral membrane protein; Region: MarC; cl00919 279010010421 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279010010422 Double zinc ribbon; Region: DZR; pfam12773 279010010423 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010010424 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279010010425 siderophore binding site; other site 279010010426 enolase; Provisional; Region: eno; PRK00077 279010010427 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 279010010428 dimer interface [polypeptide binding]; other site 279010010429 metal binding site [ion binding]; metal-binding site 279010010430 substrate binding pocket [chemical binding]; other site 279010010431 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 279010010432 phosphoglyceromutase; Provisional; Region: PRK05434 279010010433 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 279010010434 triosephosphate isomerase; Provisional; Region: PRK14565 279010010435 substrate binding site [chemical binding]; other site 279010010436 dimer interface [polypeptide binding]; other site 279010010437 catalytic triad [active] 279010010438 Phosphoglycerate kinase; Region: PGK; pfam00162 279010010439 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 279010010440 substrate binding site [chemical binding]; other site 279010010441 hinge regions; other site 279010010442 ADP binding site [chemical binding]; other site 279010010443 catalytic site [active] 279010010444 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 279010010445 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 279010010446 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 279010010447 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279010010448 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279010010449 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 279010010450 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 279010010451 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 279010010452 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010010453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010010454 Walker A/P-loop; other site 279010010455 ATP binding site [chemical binding]; other site 279010010456 Q-loop/lid; other site 279010010457 ABC transporter signature motif; other site 279010010458 Walker B; other site 279010010459 D-loop; other site 279010010460 H-loop/switch region; other site 279010010461 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010010462 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 279010010463 Uncharacterized conserved protein [Function unknown]; Region: COG1556 279010010464 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 279010010465 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 279010010466 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 279010010467 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 279010010468 Cysteine-rich domain; Region: CCG; pfam02754 279010010469 Cysteine-rich domain; Region: CCG; pfam02754 279010010470 Transcriptional regulators [Transcription]; Region: FadR; COG2186 279010010471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010010472 DNA-binding site [nucleotide binding]; DNA binding site 279010010473 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 279010010474 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 279010010475 L-lactate permease; Region: Lactate_perm; pfam02652 279010010476 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 279010010477 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 279010010478 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 279010010479 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 279010010480 YvfG protein; Region: YvfG; pfam09628 279010010481 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 279010010482 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 279010010483 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 279010010484 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 279010010485 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010010486 inhibitor-cofactor binding pocket; inhibition site 279010010487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010010488 catalytic residue [active] 279010010489 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 279010010490 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 279010010491 putative trimer interface [polypeptide binding]; other site 279010010492 putative CoA binding site [chemical binding]; other site 279010010493 Bacterial sugar transferase; Region: Bac_transf; pfam02397 279010010494 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 279010010495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010010496 active site 279010010497 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 279010010498 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 279010010499 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010010500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010010501 active site 279010010502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010503 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 279010010504 putative ADP-binding pocket [chemical binding]; other site 279010010505 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010010506 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 279010010507 active site 279010010508 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 279010010509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010510 putative ADP-binding pocket [chemical binding]; other site 279010010511 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 279010010512 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 279010010513 NAD(P) binding site [chemical binding]; other site 279010010514 homodimer interface [polypeptide binding]; other site 279010010515 substrate binding site [chemical binding]; other site 279010010516 active site 279010010517 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 279010010518 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 279010010519 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 279010010520 Chain length determinant protein; Region: Wzz; cl15801 279010010521 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010010522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010010523 non-specific DNA binding site [nucleotide binding]; other site 279010010524 salt bridge; other site 279010010525 sequence-specific DNA binding site [nucleotide binding]; other site 279010010526 Anti-repressor SinI; Region: SinI; pfam08671 279010010527 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 279010010528 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279010010529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010530 D-galactonate transporter; Region: 2A0114; TIGR00893 279010010531 putative substrate translocation pore; other site 279010010532 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 279010010533 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 279010010534 putative ligand binding site [chemical binding]; other site 279010010535 putative NAD binding site [chemical binding]; other site 279010010536 catalytic site [active] 279010010537 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 279010010538 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 279010010539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 279010010540 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 279010010541 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 279010010542 putative active site [active] 279010010543 metal binding site [ion binding]; metal-binding site 279010010544 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279010010545 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 279010010546 inhibitor site; inhibition site 279010010547 active site 279010010548 dimer interface [polypeptide binding]; other site 279010010549 catalytic residue [active] 279010010550 Propionate catabolism activator; Region: PrpR_N; pfam06506 279010010551 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 279010010552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 279010010553 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 279010010554 Predicted transcriptional regulators [Transcription]; Region: COG1733 279010010555 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279010010556 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 279010010557 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 279010010558 putative active site [active] 279010010559 putative FMN binding site [chemical binding]; other site 279010010560 putative substrate binding site [chemical binding]; other site 279010010561 putative catalytic residue [active] 279010010562 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 279010010563 active site 279010010564 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 279010010565 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010010566 substrate binding [chemical binding]; other site 279010010567 active site 279010010568 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010010569 TM2 domain; Region: TM2; pfam05154 279010010570 Clp protease; Region: CLP_protease; pfam00574 279010010571 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 279010010572 oligomer interface [polypeptide binding]; other site 279010010573 active site residues [active] 279010010574 TIGR00730 family protein; Region: TIGR00730 279010010575 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 279010010576 metal binding site [ion binding]; metal-binding site 279010010577 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 279010010578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010010579 Zn2+ binding site [ion binding]; other site 279010010580 Mg2+ binding site [ion binding]; other site 279010010581 putative transporter; Provisional; Region: PRK11660 279010010582 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 279010010583 Sulfate transporter family; Region: Sulfate_transp; pfam00916 279010010584 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 279010010585 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 279010010586 active site clefts [active] 279010010587 zinc binding site [ion binding]; other site 279010010588 dimer interface [polypeptide binding]; other site 279010010589 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 279010010590 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 279010010591 dimerization interface [polypeptide binding]; other site 279010010592 ligand binding site [chemical binding]; other site 279010010593 NADP binding site [chemical binding]; other site 279010010594 catalytic site [active] 279010010595 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 279010010596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010010597 dimerization interface [polypeptide binding]; other site 279010010598 putative DNA binding site [nucleotide binding]; other site 279010010599 putative Zn2+ binding site [ion binding]; other site 279010010600 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 279010010601 active site 279010010602 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 279010010603 RNAase interaction site [polypeptide binding]; other site 279010010604 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 279010010605 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279010010606 dimerization domain swap beta strand [polypeptide binding]; other site 279010010607 regulatory protein interface [polypeptide binding]; other site 279010010608 active site 279010010609 regulatory phosphorylation site [posttranslational modification]; other site 279010010610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 279010010611 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 279010010612 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 279010010613 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 279010010614 phosphate binding site [ion binding]; other site 279010010615 putative substrate binding pocket [chemical binding]; other site 279010010616 dimer interface [polypeptide binding]; other site 279010010617 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 279010010618 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 279010010619 putative active site [active] 279010010620 nucleotide binding site [chemical binding]; other site 279010010621 nudix motif; other site 279010010622 putative metal binding site [ion binding]; other site 279010010623 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 279010010624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010010625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010010626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010010627 binding surface 279010010628 TPR motif; other site 279010010629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010010630 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279010010631 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 279010010632 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 279010010633 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 279010010634 metal binding site [ion binding]; metal-binding site 279010010635 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 279010010636 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 279010010637 substrate binding site [chemical binding]; other site 279010010638 glutamase interaction surface [polypeptide binding]; other site 279010010639 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 279010010640 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 279010010641 catalytic residues [active] 279010010642 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 279010010643 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 279010010644 putative active site [active] 279010010645 oxyanion strand; other site 279010010646 catalytic triad [active] 279010010647 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 279010010648 putative active site pocket [active] 279010010649 4-fold oligomerization interface [polypeptide binding]; other site 279010010650 metal binding residues [ion binding]; metal-binding site 279010010651 3-fold/trimer interface [polypeptide binding]; other site 279010010652 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 279010010653 histidinol dehydrogenase; Region: hisD; TIGR00069 279010010654 NAD binding site [chemical binding]; other site 279010010655 dimerization interface [polypeptide binding]; other site 279010010656 product binding site; other site 279010010657 substrate binding site [chemical binding]; other site 279010010658 zinc binding site [ion binding]; other site 279010010659 catalytic residues [active] 279010010660 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 279010010661 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 279010010662 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 279010010663 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 279010010664 dimer interface [polypeptide binding]; other site 279010010665 motif 1; other site 279010010666 active site 279010010667 motif 2; other site 279010010668 motif 3; other site 279010010669 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 279010010670 putative active site [active] 279010010671 Pectate lyase; Region: Pectate_lyase; pfam03211 279010010672 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 279010010673 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 279010010674 trimer interface [polypeptide binding]; other site 279010010675 active site 279010010676 substrate binding site [chemical binding]; other site 279010010677 CoA binding site [chemical binding]; other site 279010010678 pyrophosphatase PpaX; Provisional; Region: PRK13288 279010010679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010680 active site 279010010681 motif I; other site 279010010682 motif II; other site 279010010683 Nucleoside recognition; Region: Gate; pfam07670 279010010684 Nucleoside recognition; Region: Gate; pfam07670 279010010685 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 279010010686 HPr kinase/phosphorylase; Provisional; Region: PRK05428 279010010687 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 279010010688 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 279010010689 Hpr binding site; other site 279010010690 active site 279010010691 homohexamer subunit interaction site [polypeptide binding]; other site 279010010692 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010010693 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010010694 putative Zn2+ binding site [ion binding]; other site 279010010695 putative DNA binding site [nucleotide binding]; other site 279010010696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010010698 putative substrate translocation pore; other site 279010010699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010700 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 279010010701 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010010702 putative active site [active] 279010010703 putative metal binding site [ion binding]; other site 279010010704 Predicted membrane protein [Function unknown]; Region: COG1950 279010010705 PspC domain; Region: PspC; pfam04024 279010010706 Uncharacterized conserved protein [Function unknown]; Region: COG3595 279010010707 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279010010708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010010709 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010010710 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 279010010711 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 279010010712 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 279010010713 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 279010010714 excinuclease ABC subunit B; Provisional; Region: PRK05298 279010010715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010010716 ATP binding site [chemical binding]; other site 279010010717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010010718 nucleotide binding region [chemical binding]; other site 279010010719 ATP-binding site [chemical binding]; other site 279010010720 Ultra-violet resistance protein B; Region: UvrB; pfam12344 279010010721 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 279010010722 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010010723 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 279010010724 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 279010010725 C-terminal peptidase (prc); Region: prc; TIGR00225 279010010726 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 279010010727 protein binding site [polypeptide binding]; other site 279010010728 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 279010010729 Catalytic dyad [active] 279010010730 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279010010731 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 279010010732 tartrate dehydrogenase; Provisional; Region: PRK08194 279010010733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 279010010734 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279010010735 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010010736 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 279010010737 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 279010010738 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 279010010739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010010740 Walker A/P-loop; other site 279010010741 ATP binding site [chemical binding]; other site 279010010742 Q-loop/lid; other site 279010010743 ABC transporter signature motif; other site 279010010744 Walker B; other site 279010010745 D-loop; other site 279010010746 H-loop/switch region; other site 279010010747 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 279010010748 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 279010010749 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010010750 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010010751 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010010752 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010010753 peptide chain release factor 2; Provisional; Region: PRK06746 279010010754 This domain is found in peptide chain release factors; Region: PCRF; smart00937 279010010755 RF-1 domain; Region: RF-1; pfam00472 279010010756 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 279010010757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 279010010758 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 279010010759 nucleotide binding region [chemical binding]; other site 279010010760 helicase superfamily c-terminal domain; Region: HELICc; smart00490 279010010761 ATP-binding site [chemical binding]; other site 279010010762 SEC-C motif; Region: SEC-C; pfam02810 279010010763 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 279010010764 30S subunit binding site; other site 279010010765 Flagellar protein FliT; Region: FliT; cl05125 279010010766 flagellar protein FliS; Validated; Region: fliS; PRK05685 279010010767 flagellar capping protein; Validated; Region: fliD; PRK07737 279010010768 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 279010010769 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 279010010770 flagellar protein FlaG; Provisional; Region: PRK07738 279010010771 flagellin; Provisional; Region: PRK12804 279010010772 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 279010010773 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 279010010774 carbon storage regulator; Provisional; Region: PRK01712 279010010775 flagellar assembly protein FliW; Provisional; Region: PRK13285 279010010776 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 279010010777 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 279010010778 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 279010010779 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 279010010780 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 279010010781 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 279010010782 FlgN protein; Region: FlgN; pfam05130 279010010783 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 279010010784 flagellar operon protein TIGR03826; Region: YvyF 279010010785 comF family protein; Region: comF; TIGR00201 279010010786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010010787 active site 279010010788 Late competence development protein ComFB; Region: ComFB; pfam10719 279010010789 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 279010010790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010010791 ATP binding site [chemical binding]; other site 279010010792 putative Mg++ binding site [ion binding]; other site 279010010793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010010794 nucleotide binding region [chemical binding]; other site 279010010795 ATP-binding site [chemical binding]; other site 279010010796 EDD domain protein, DegV family; Region: DegV; TIGR00762 279010010797 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 279010010798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010010799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010010800 active site 279010010801 phosphorylation site [posttranslational modification] 279010010802 intermolecular recognition site; other site 279010010803 dimerization interface [polypeptide binding]; other site 279010010804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010010805 DNA binding residues [nucleotide binding] 279010010806 dimerization interface [polypeptide binding]; other site 279010010807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010010808 Histidine kinase; Region: HisKA_3; pfam07730 279010010809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010010810 ATP binding site [chemical binding]; other site 279010010811 Mg2+ binding site [ion binding]; other site 279010010812 G-X-G motif; other site 279010010813 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 279010010814 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 279010010815 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 279010010816 Transcriptional regulator [Transcription]; Region: LytR; COG1316 279010010817 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 279010010818 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 279010010819 Mg++ binding site [ion binding]; other site 279010010820 putative catalytic motif [active] 279010010821 substrate binding site [chemical binding]; other site 279010010822 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 279010010823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010824 putative homodimer interface [polypeptide binding]; other site 279010010825 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010010826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 279010010827 active site 279010010828 O-Antigen ligase; Region: Wzy_C; pfam04932 279010010829 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 279010010830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010831 NAD(P) binding site [chemical binding]; other site 279010010832 active site 279010010833 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 279010010834 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 279010010835 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 279010010836 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010837 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 279010010838 colanic acid exporter; Provisional; Region: PRK10459 279010010839 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 279010010840 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 279010010841 Bacterial sugar transferase; Region: Bac_transf; pfam02397 279010010842 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010843 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 279010010844 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010845 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010846 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010010847 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010010848 active site 279010010849 metal binding site [ion binding]; metal-binding site 279010010850 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010851 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 279010010852 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010853 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010854 Stage II sporulation protein; Region: SpoIID; pfam08486 279010010855 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 279010010856 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 279010010857 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 279010010858 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 279010010859 active site 279010010860 homodimer interface [polypeptide binding]; other site 279010010861 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 279010010862 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 279010010863 active site 279010010864 tetramer interface; other site 279010010865 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 279010010866 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 279010010867 Walker A/P-loop; other site 279010010868 ATP binding site [chemical binding]; other site 279010010869 Q-loop/lid; other site 279010010870 ABC transporter signature motif; other site 279010010871 Walker B; other site 279010010872 D-loop; other site 279010010873 H-loop/switch region; other site 279010010874 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 279010010875 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 279010010876 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279010010877 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279010010878 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010010879 SH3-like domain; Region: SH3_8; pfam13457 279010010880 SH3-like domain; Region: SH3_8; pfam13457 279010010881 SH3-like domain; Region: SH3_8; pfam13457 279010010882 SH3-like domain; Region: SH3_8; pfam13457 279010010883 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 279010010884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010885 putative ADP-binding pocket [chemical binding]; other site 279010010886 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279010010887 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279010010888 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 279010010889 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 279010010890 active site 279010010891 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 279010010892 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 279010010893 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279010010894 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279010010895 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 279010010896 Bacterial SH3 domain; Region: SH3_3; pfam08239 279010010897 Lysozyme subfamily 2; Region: LYZ2; smart00047 279010010898 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 279010010899 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 279010010900 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 279010010901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010010902 FeS/SAM binding site; other site 279010010903 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 279010010904 Class III ribonucleotide reductase; Region: RNR_III; cd01675 279010010905 effector binding site; other site 279010010906 active site 279010010907 Zn binding site [ion binding]; other site 279010010908 glycine loop; other site 279010010909 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 279010010910 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 279010010911 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 279010010912 active site 279010010913 intersubunit interface [polypeptide binding]; other site 279010010914 catalytic residue [active] 279010010915 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010010916 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279010010917 substrate binding site [chemical binding]; other site 279010010918 ATP binding site [chemical binding]; other site 279010010919 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010010920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010010921 DNA binding site [nucleotide binding] 279010010922 domain linker motif; other site 279010010923 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 279010010924 putative dimerization interface [polypeptide binding]; other site 279010010925 putative ligand binding site [chemical binding]; other site 279010010926 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 279010010927 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 279010010928 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 279010010929 NADP binding site [chemical binding]; other site 279010010930 homodimer interface [polypeptide binding]; other site 279010010931 active site 279010010932 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 279010010933 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 279010010934 NAD binding site [chemical binding]; other site 279010010935 catalytic Zn binding site [ion binding]; other site 279010010936 structural Zn binding site [ion binding]; other site 279010010937 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279010010938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010939 putative substrate translocation pore; other site 279010010940 Transcriptional regulator [Transcription]; Region: LytR; COG1316 279010010941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010942 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010010943 active site 279010010944 motif I; other site 279010010945 motif II; other site 279010010946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010947 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010010948 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010010949 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010010950 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010010951 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 279010010952 NlpC/P60 family; Region: NLPC_P60; pfam00877 279010010953 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 279010010954 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 279010010955 putative active site [active] 279010010956 putative metal binding site [ion binding]; other site 279010010957 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 279010010958 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 279010010959 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010010960 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010010961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010010962 DNA binding site [nucleotide binding] 279010010963 domain linker motif; other site 279010010964 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 279010010965 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010010966 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 279010010967 substrate binding site [chemical binding]; other site 279010010968 dimer interface [polypeptide binding]; other site 279010010969 ATP binding site [chemical binding]; other site 279010010970 D-ribose pyranase; Provisional; Region: PRK11797 279010010971 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 279010010972 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 279010010973 Walker A/P-loop; other site 279010010974 ATP binding site [chemical binding]; other site 279010010975 Q-loop/lid; other site 279010010976 ABC transporter signature motif; other site 279010010977 Walker B; other site 279010010978 D-loop; other site 279010010979 H-loop/switch region; other site 279010010980 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 279010010981 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 279010010982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 279010010983 TM-ABC transporter signature motif; other site 279010010984 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 279010010985 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 279010010986 ligand binding site [chemical binding]; other site 279010010987 dimerization interface [polypeptide binding]; other site 279010010988 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 279010010989 acetolactate synthase; Reviewed; Region: PRK08617 279010010990 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279010010991 PYR/PP interface [polypeptide binding]; other site 279010010992 dimer interface [polypeptide binding]; other site 279010010993 TPP binding site [chemical binding]; other site 279010010994 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279010010995 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 279010010996 TPP-binding site [chemical binding]; other site 279010010997 dimer interface [polypeptide binding]; other site 279010010998 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 279010010999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279010011000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010011001 dimerization interface [polypeptide binding]; other site 279010011002 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 279010011003 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 279010011004 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 279010011005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010011006 putative DNA binding site [nucleotide binding]; other site 279010011007 putative Zn2+ binding site [ion binding]; other site 279010011008 AsnC family; Region: AsnC_trans_reg; pfam01037 279010011009 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 279010011010 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 279010011011 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 279010011012 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 279010011013 Chain length determinant protein; Region: Wzz; cl15801 279010011014 SNF2 Helicase protein; Region: DUF3670; pfam12419 279010011015 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 279010011016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010011017 ATP binding site [chemical binding]; other site 279010011018 putative Mg++ binding site [ion binding]; other site 279010011019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010011020 nucleotide binding region [chemical binding]; other site 279010011021 ATP-binding site [chemical binding]; other site 279010011022 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010011023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010011024 active site 279010011025 motif I; other site 279010011026 motif II; other site 279010011027 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 279010011028 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010011029 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 279010011030 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 279010011031 Class I aldolases; Region: Aldolase_Class_I; cl17187 279010011032 catalytic residue [active] 279010011033 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 279010011034 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 279010011035 putative NAD(P) binding site [chemical binding]; other site 279010011036 active site 279010011037 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 279010011038 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 279010011039 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 279010011040 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 279010011041 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 279010011042 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 279010011043 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279010011044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010011045 dimerization interface [polypeptide binding]; other site 279010011046 putative DNA binding site [nucleotide binding]; other site 279010011047 putative Zn2+ binding site [ion binding]; other site 279010011048 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279010011049 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279010011050 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279010011051 dimer interface [polypeptide binding]; other site 279010011052 ssDNA binding site [nucleotide binding]; other site 279010011053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010011054 YwpF-like protein; Region: YwpF; pfam14183 279010011055 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 279010011056 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 279010011057 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 279010011058 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 279010011059 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 279010011060 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 279010011061 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 279010011062 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 279010011063 rod shape-determining protein Mbl; Provisional; Region: PRK13928 279010011064 MreB and similar proteins; Region: MreB_like; cd10225 279010011065 nucleotide binding site [chemical binding]; other site 279010011066 Mg binding site [ion binding]; other site 279010011067 putative protofilament interaction site [polypeptide binding]; other site 279010011068 RodZ interaction site [polypeptide binding]; other site 279010011069 Stage III sporulation protein D; Region: SpoIIID; pfam12116 279010011070 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010011071 MarR family; Region: MarR; pfam01047 279010011072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010011073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011074 putative substrate translocation pore; other site 279010011075 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 279010011076 active site 279010011077 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279010011078 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 279010011079 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 279010011080 DHHA2 domain; Region: DHHA2; pfam02833 279010011081 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 279010011082 dimanganese center [ion binding]; other site 279010011083 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 279010011084 FOG: CBS domain [General function prediction only]; Region: COG0517 279010011085 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 279010011086 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 279010011087 Cl binding site [ion binding]; other site 279010011088 oligomer interface [polypeptide binding]; other site 279010011089 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 279010011090 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010011091 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010011092 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010011093 Transporter associated domain; Region: CorC_HlyC; smart01091 279010011094 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 279010011095 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 279010011096 Nitrogen regulatory protein P-II; Region: P-II; smart00938 279010011097 Clp protease; Region: CLP_protease; pfam00574 279010011098 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 279010011099 oligomer interface [polypeptide binding]; other site 279010011100 active site residues [active] 279010011101 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279010011102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010011103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010011104 DNA binding residues [nucleotide binding] 279010011105 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279010011106 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010011107 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279010011108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010011109 Coenzyme A binding pocket [chemical binding]; other site 279010011110 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 279010011111 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 279010011112 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 279010011113 putative active site [active] 279010011114 catalytic site [active] 279010011115 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 279010011116 putative active site [active] 279010011117 catalytic site [active] 279010011118 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010011119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011120 putative substrate translocation pore; other site 279010011121 MbtH-like protein; Region: MbtH; cl01279 279010011122 Condensation domain; Region: Condensation; pfam00668 279010011123 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 279010011124 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 279010011125 acyl-activating enzyme (AAE) consensus motif; other site 279010011126 AMP binding site [chemical binding]; other site 279010011127 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010011128 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 279010011129 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010011130 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 279010011131 acyl-activating enzyme (AAE) consensus motif; other site 279010011132 AMP binding site [chemical binding]; other site 279010011133 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 279010011134 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 279010011135 Isochorismatase family; Region: Isochorismatase; pfam00857 279010011136 catalytic triad [active] 279010011137 conserved cis-peptide bond; other site 279010011138 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 279010011139 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 279010011140 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 279010011141 acyl-activating enzyme (AAE) consensus motif; other site 279010011142 active site 279010011143 AMP binding site [chemical binding]; other site 279010011144 substrate binding site [chemical binding]; other site 279010011145 isochorismate synthase DhbC; Validated; Region: PRK06923 279010011146 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 279010011147 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 279010011148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011149 NAD(P) binding site [chemical binding]; other site 279010011150 active site 279010011151 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 279010011152 Putative esterase; Region: Esterase; pfam00756 279010011153 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010011154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010011155 dimer interface [polypeptide binding]; other site 279010011156 putative PBP binding regions; other site 279010011157 ABC-ATPase subunit interface; other site 279010011158 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010011159 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010011160 ABC-ATPase subunit interface; other site 279010011161 dimer interface [polypeptide binding]; other site 279010011162 putative PBP binding regions; other site 279010011163 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010011164 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010011165 intersubunit interface [polypeptide binding]; other site 279010011166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010011167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010011168 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010011169 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279010011170 intersubunit interface [polypeptide binding]; other site 279010011171 Transposase; Region: HTH_Tnp_1; cl17663 279010011172 putative transposase OrfB; Reviewed; Region: PHA02517 279010011173 HTH-like domain; Region: HTH_21; pfam13276 279010011174 Integrase core domain; Region: rve; pfam00665 279010011175 Integrase core domain; Region: rve_3; pfam13683 279010011176 Homeodomain-like domain; Region: HTH_23; pfam13384 279010011177 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 279010011178 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010011179 NAD binding site [chemical binding]; other site 279010011180 substrate binding site [chemical binding]; other site 279010011181 putative active site [active] 279010011182 Predicted transcriptional regulator [Transcription]; Region: COG1959 279010011183 Transcriptional regulator; Region: Rrf2; pfam02082 279010011184 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; Region: GRAM; smart00568 279010011185 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 279010011186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010011187 FeS/SAM binding site; other site 279010011188 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 279010011189 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 279010011190 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 279010011191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011192 putative substrate translocation pore; other site 279010011193 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 279010011194 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010011195 molybdopterin cofactor binding site; other site 279010011196 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 279010011197 molybdopterin cofactor binding site; other site 279010011198 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010011199 metal ion-dependent adhesion site (MIDAS); other site 279010011200 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010011201 metal ion-dependent adhesion site (MIDAS); other site 279010011202 Stage II sporulation protein; Region: SpoIID; pfam08486 279010011203 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 279010011204 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 279010011205 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 279010011206 hinge; other site 279010011207 active site 279010011208 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 279010011209 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 279010011210 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 279010011211 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 279010011212 gamma subunit interface [polypeptide binding]; other site 279010011213 epsilon subunit interface [polypeptide binding]; other site 279010011214 LBP interface [polypeptide binding]; other site 279010011215 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 279010011216 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 279010011217 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 279010011218 alpha subunit interaction interface [polypeptide binding]; other site 279010011219 Walker A motif; other site 279010011220 ATP binding site [chemical binding]; other site 279010011221 Walker B motif; other site 279010011222 inhibitor binding site; inhibition site 279010011223 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 279010011224 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 279010011225 core domain interface [polypeptide binding]; other site 279010011226 delta subunit interface [polypeptide binding]; other site 279010011227 epsilon subunit interface [polypeptide binding]; other site 279010011228 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 279010011229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 279010011230 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 279010011231 beta subunit interaction interface [polypeptide binding]; other site 279010011232 Walker A motif; other site 279010011233 ATP binding site [chemical binding]; other site 279010011234 Walker B motif; other site 279010011235 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 279010011236 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 279010011237 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 279010011238 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 279010011239 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 279010011240 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 279010011241 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 279010011242 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 279010011243 ATP synthase I chain; Region: ATP_synt_I; pfam03899 279010011244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010011245 active site 279010011246 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 279010011247 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 279010011248 dimer interface [polypeptide binding]; other site 279010011249 active site 279010011250 glycine-pyridoxal phosphate binding site [chemical binding]; other site 279010011251 folate binding site [chemical binding]; other site 279010011252 hypothetical protein; Provisional; Region: PRK13690 279010011253 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 279010011254 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 279010011255 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279010011256 active site 279010011257 Predicted membrane protein [Function unknown]; Region: COG1971 279010011258 Domain of unknown function DUF; Region: DUF204; pfam02659 279010011259 Domain of unknown function DUF; Region: DUF204; pfam02659 279010011260 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 279010011261 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 279010011262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279010011263 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 279010011264 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 279010011265 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010011266 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010011267 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 279010011268 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 279010011269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010011270 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 279010011271 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010011272 inhibitor-cofactor binding pocket; inhibition site 279010011273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010011274 catalytic residue [active] 279010011275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010011276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010011277 DNA binding site [nucleotide binding] 279010011278 domain linker motif; other site 279010011279 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 279010011280 putative ligand binding site [chemical binding]; other site 279010011281 putative dimerization interface [polypeptide binding]; other site 279010011282 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 279010011283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010011284 S-adenosylmethionine binding site [chemical binding]; other site 279010011285 peptide chain release factor 1; Validated; Region: prfA; PRK00591 279010011286 This domain is found in peptide chain release factors; Region: PCRF; smart00937 279010011287 RF-1 domain; Region: RF-1; pfam00472 279010011288 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 279010011289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010011290 putative metal binding site [ion binding]; other site 279010011291 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 279010011292 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 279010011293 DNA binding residues [nucleotide binding] 279010011294 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 279010011295 malate dehydrogenase; Provisional; Region: PRK13529 279010011296 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010011297 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 279010011298 NAD(P) binding site [chemical binding]; other site 279010011299 thymidine kinase; Provisional; Region: PRK04296 279010011300 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 279010011301 transcription termination factor Rho; Provisional; Region: rho; PRK09376 279010011302 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 279010011303 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 279010011304 RNA binding site [nucleotide binding]; other site 279010011305 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 279010011306 multimer interface [polypeptide binding]; other site 279010011307 Walker A motif; other site 279010011308 ATP binding site [chemical binding]; other site 279010011309 Walker B motif; other site 279010011310 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 279010011311 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 279010011312 putative active site [active] 279010011313 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 279010011314 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 279010011315 hinge; other site 279010011316 active site 279010011317 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 279010011318 active site 279010011319 intersubunit interactions; other site 279010011320 catalytic residue [active] 279010011321 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 279010011322 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279010011323 intersubunit interface [polypeptide binding]; other site 279010011324 active site 279010011325 zinc binding site [ion binding]; other site 279010011326 Na+ binding site [ion binding]; other site 279010011327 Response regulator receiver domain; Region: Response_reg; pfam00072 279010011328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011329 active site 279010011330 phosphorylation site [posttranslational modification] 279010011331 intermolecular recognition site; other site 279010011332 dimerization interface [polypeptide binding]; other site 279010011333 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 279010011334 CTP synthetase; Validated; Region: pyrG; PRK05380 279010011335 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 279010011336 Catalytic site [active] 279010011337 active site 279010011338 UTP binding site [chemical binding]; other site 279010011339 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 279010011340 active site 279010011341 putative oxyanion hole; other site 279010011342 catalytic triad [active] 279010011343 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 279010011344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010011345 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 279010011346 FAD binding site [chemical binding]; other site 279010011347 homotetramer interface [polypeptide binding]; other site 279010011348 substrate binding pocket [chemical binding]; other site 279010011349 catalytic base [active] 279010011350 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010011351 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 279010011352 FAD binding site [chemical binding]; other site 279010011353 homotetramer interface [polypeptide binding]; other site 279010011354 substrate binding pocket [chemical binding]; other site 279010011355 catalytic base [active] 279010011356 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 279010011357 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 279010011358 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 279010011359 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 279010011360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 279010011361 dimer interface [polypeptide binding]; other site 279010011362 active site 279010011363 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 279010011364 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 279010011365 4Fe-4S binding domain; Region: Fer4; cl02805 279010011366 Cysteine-rich domain; Region: CCG; pfam02754 279010011367 Cysteine-rich domain; Region: CCG; pfam02754 279010011368 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 279010011369 PLD-like domain; Region: PLDc_2; pfam13091 279010011370 putative active site [active] 279010011371 catalytic site [active] 279010011372 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 279010011373 PLD-like domain; Region: PLDc_2; pfam13091 279010011374 putative active site [active] 279010011375 catalytic site [active] 279010011376 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 279010011377 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 279010011378 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 279010011379 active site 279010011380 HIGH motif; other site 279010011381 KMSK motif region; other site 279010011382 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 279010011383 tRNA binding surface [nucleotide binding]; other site 279010011384 anticodon binding site; other site 279010011385 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 279010011386 agmatinase; Region: agmatinase; TIGR01230 279010011387 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 279010011388 putative active site [active] 279010011389 Mn binding site [ion binding]; other site 279010011390 spermidine synthase; Provisional; Region: PRK00811 279010011391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010011392 Transglycosylase; Region: Transgly; pfam00912 279010011393 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010011394 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 279010011395 YwhD family; Region: YwhD; pfam08741 279010011396 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 279010011397 Peptidase family M50; Region: Peptidase_M50; pfam02163 279010011398 active site 279010011399 putative substrate binding region [chemical binding]; other site 279010011400 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 279010011401 active site 1 [active] 279010011402 dimer interface [polypeptide binding]; other site 279010011403 hexamer interface [polypeptide binding]; other site 279010011404 active site 2 [active] 279010011405 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 279010011406 active site 279010011407 Uncharacterized conserved protein [Function unknown]; Region: COG3465 279010011408 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 279010011409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010011410 Zn2+ binding site [ion binding]; other site 279010011411 Mg2+ binding site [ion binding]; other site 279010011412 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 279010011413 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 279010011414 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 279010011415 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 279010011416 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279010011417 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 279010011418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279010011419 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 279010011420 benzoate transport; Region: 2A0115; TIGR00895 279010011421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011422 putative substrate translocation pore; other site 279010011423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011424 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 279010011425 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 279010011426 active site 279010011427 metal binding site [ion binding]; metal-binding site 279010011428 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 279010011429 active site 1 [active] 279010011430 dimer interface [polypeptide binding]; other site 279010011431 hexamer interface [polypeptide binding]; other site 279010011432 active site 2 [active] 279010011433 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 279010011434 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 279010011435 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 279010011436 NAD binding site [chemical binding]; other site 279010011437 catalytic residues [active] 279010011438 Transcriptional regulator [Transcription]; Region: IclR; COG1414 279010011439 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 279010011440 Bacterial transcriptional regulator; Region: IclR; pfam01614 279010011441 Amidohydrolase; Region: Amidohydro_2; pfam04909 279010011442 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 279010011443 putative heme peroxidase; Provisional; Region: PRK12276 279010011444 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279010011445 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 279010011446 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 279010011447 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279010011448 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 279010011449 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 279010011450 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 279010011451 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 279010011452 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010011453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010011454 Walker A/P-loop; other site 279010011455 ATP binding site [chemical binding]; other site 279010011456 Q-loop/lid; other site 279010011457 ABC transporter signature motif; other site 279010011458 Walker B; other site 279010011459 D-loop; other site 279010011460 H-loop/switch region; other site 279010011461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010011462 Histidine kinase; Region: HisKA_3; pfam07730 279010011463 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 279010011464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010011465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011466 active site 279010011467 phosphorylation site [posttranslational modification] 279010011468 intermolecular recognition site; other site 279010011469 dimerization interface [polypeptide binding]; other site 279010011470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010011471 DNA binding residues [nucleotide binding] 279010011472 dimerization interface [polypeptide binding]; other site 279010011473 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 279010011474 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 279010011475 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 279010011476 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 279010011477 NAD(P) binding site [chemical binding]; other site 279010011478 catalytic residues [active] 279010011479 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 279010011480 ligand binding site [chemical binding]; other site 279010011481 active site 279010011482 UGI interface [polypeptide binding]; other site 279010011483 catalytic site [active] 279010011484 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 279010011485 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010011486 active site 279010011487 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 279010011488 dimer interface [polypeptide binding]; other site 279010011489 substrate binding site [chemical binding]; other site 279010011490 ATP binding site [chemical binding]; other site 279010011491 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 279010011492 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010011493 substrate binding [chemical binding]; other site 279010011494 active site 279010011495 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010011496 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 279010011497 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010011498 active site turn [active] 279010011499 phosphorylation site [posttranslational modification] 279010011500 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010011501 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010011502 CAT RNA binding domain; Region: CAT_RBD; smart01061 279010011503 PRD domain; Region: PRD; pfam00874 279010011504 PRD domain; Region: PRD; pfam00874 279010011505 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010011506 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 279010011507 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 279010011508 putative active site [active] 279010011509 catalytic triad [active] 279010011510 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 279010011511 PA/protease domain interface [polypeptide binding]; other site 279010011512 putative integrin binding motif; other site 279010011513 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 279010011514 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 279010011515 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 279010011516 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279010011517 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 279010011518 dimer interface [polypeptide binding]; other site 279010011519 FMN binding site [chemical binding]; other site 279010011520 NADPH bind site [chemical binding]; other site 279010011521 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010011522 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279010011523 metal binding site [ion binding]; metal-binding site 279010011524 dimer interface [polypeptide binding]; other site 279010011525 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 279010011526 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 279010011527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 279010011528 Nucleoside recognition; Region: Gate; pfam07670 279010011529 Clostripain family; Region: Peptidase_C11; pfam03415 279010011530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010011531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010011532 Coenzyme A binding pocket [chemical binding]; other site 279010011533 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010011534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010011535 Walker A/P-loop; other site 279010011536 ATP binding site [chemical binding]; other site 279010011537 Q-loop/lid; other site 279010011538 ABC transporter signature motif; other site 279010011539 Walker B; other site 279010011540 D-loop; other site 279010011541 H-loop/switch region; other site 279010011542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010011543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010011544 Walker A/P-loop; other site 279010011545 ATP binding site [chemical binding]; other site 279010011546 Q-loop/lid; other site 279010011547 ABC transporter signature motif; other site 279010011548 Walker B; other site 279010011549 D-loop; other site 279010011550 H-loop/switch region; other site 279010011551 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 279010011552 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 279010011553 Ligand Binding Site [chemical binding]; other site 279010011554 Molecular Tunnel; other site 279010011555 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 279010011556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010011557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011558 active site 279010011559 phosphorylation site [posttranslational modification] 279010011560 intermolecular recognition site; other site 279010011561 dimerization interface [polypeptide binding]; other site 279010011562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010011563 DNA binding residues [nucleotide binding] 279010011564 dimerization interface [polypeptide binding]; other site 279010011565 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 279010011566 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 279010011567 Subunit I/III interface [polypeptide binding]; other site 279010011568 Subunit III/IV interface [polypeptide binding]; other site 279010011569 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 279010011570 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 279010011571 D-pathway; other site 279010011572 Putative ubiquinol binding site [chemical binding]; other site 279010011573 Low-spin heme (heme b) binding site [chemical binding]; other site 279010011574 Putative water exit pathway; other site 279010011575 Binuclear center (heme o3/CuB) [ion binding]; other site 279010011576 K-pathway; other site 279010011577 Putative proton exit pathway; other site 279010011578 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 279010011579 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 279010011580 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 279010011581 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010011582 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 279010011583 NAD binding site [chemical binding]; other site 279010011584 homodimer interface [polypeptide binding]; other site 279010011585 active site 279010011586 substrate binding site [chemical binding]; other site 279010011587 Anti-repressor SinI; Region: SinI; pfam08671 279010011588 Protein of unknown function, DUF485; Region: DUF485; pfam04341 279010011589 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 279010011590 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 279010011591 Na binding site [ion binding]; other site 279010011592 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 279010011593 N- and C-terminal domain interface [polypeptide binding]; other site 279010011594 D-xylulose kinase; Region: XylB; TIGR01312 279010011595 active site 279010011596 MgATP binding site [chemical binding]; other site 279010011597 catalytic site [active] 279010011598 metal binding site [ion binding]; metal-binding site 279010011599 xylulose binding site [chemical binding]; other site 279010011600 homodimer interface [polypeptide binding]; other site 279010011601 xylose isomerase; Provisional; Region: PRK05474 279010011602 xylose isomerase; Region: xylose_isom_A; TIGR02630 279010011603 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 279010011604 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279010011605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010011606 nucleotide binding site [chemical binding]; other site 279010011607 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 279010011608 thiamine phosphate binding site [chemical binding]; other site 279010011609 active site 279010011610 pyrophosphate binding site [ion binding]; other site 279010011611 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 279010011612 substrate binding site [chemical binding]; other site 279010011613 multimerization interface [polypeptide binding]; other site 279010011614 ATP binding site [chemical binding]; other site 279010011615 holin-like protein; Validated; Region: PRK01658 279010011616 TIGR00659 family protein; Region: TIGR00659 279010011617 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 279010011618 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 279010011619 Na binding site [ion binding]; other site 279010011620 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 279010011621 PUA domain; Region: PUA; cl00607 279010011622 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 279010011623 putative RNA binding site [nucleotide binding]; other site 279010011624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010011625 S-adenosylmethionine binding site [chemical binding]; other site 279010011626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010011627 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 279010011628 active site 279010011629 metal binding site [ion binding]; metal-binding site 279010011630 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 279010011631 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 279010011632 Ligand binding site; other site 279010011633 metal-binding site 279010011634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010011635 Histidine kinase; Region: HisKA_3; pfam07730 279010011636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011637 ATP binding site [chemical binding]; other site 279010011638 Mg2+ binding site [ion binding]; other site 279010011639 G-X-G motif; other site 279010011640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010011641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011642 active site 279010011643 phosphorylation site [posttranslational modification] 279010011644 intermolecular recognition site; other site 279010011645 dimerization interface [polypeptide binding]; other site 279010011646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010011647 DNA binding residues [nucleotide binding] 279010011648 dimerization interface [polypeptide binding]; other site 279010011649 MMPL family; Region: MMPL; pfam03176 279010011650 MMPL family; Region: MMPL; pfam03176 279010011651 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 279010011652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011653 D-galactonate transporter; Region: 2A0114; TIGR00893 279010011654 putative substrate translocation pore; other site 279010011655 galactonate dehydratase; Provisional; Region: PRK14017 279010011656 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 279010011657 putative active site pocket [active] 279010011658 putative metal binding site [ion binding]; other site 279010011659 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 279010011660 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 279010011661 active site 279010011662 intersubunit interface [polypeptide binding]; other site 279010011663 catalytic residue [active] 279010011664 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010011665 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279010011666 substrate binding site [chemical binding]; other site 279010011667 ATP binding site [chemical binding]; other site 279010011668 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 279010011669 Transcriptional regulator [Transcription]; Region: IclR; COG1414 279010011670 Bacterial transcriptional regulator; Region: IclR; pfam01614 279010011671 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 279010011672 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 279010011673 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 279010011674 putative integrin binding motif; other site 279010011675 PA/protease domain interface [polypeptide binding]; other site 279010011676 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 279010011677 metal binding site [ion binding]; metal-binding site 279010011678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010011680 putative substrate translocation pore; other site 279010011681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011682 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279010011683 synthetase active site [active] 279010011684 NTP binding site [chemical binding]; other site 279010011685 metal binding site [ion binding]; metal-binding site 279010011686 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 279010011687 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 279010011688 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 279010011689 acyl-activating enzyme (AAE) consensus motif; other site 279010011690 AMP binding site [chemical binding]; other site 279010011691 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 279010011692 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 279010011693 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 279010011694 DltD N-terminal region; Region: DltD_N; pfam04915 279010011695 DltD central region; Region: DltD_M; pfam04918 279010011696 DltD C-terminal region; Region: DltD_C; pfam04914 279010011697 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 279010011698 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 279010011699 homodimer interface [polypeptide binding]; other site 279010011700 substrate-cofactor binding pocket; other site 279010011701 catalytic residue [active] 279010011702 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010011703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011704 putative substrate translocation pore; other site 279010011705 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 279010011706 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 279010011707 NAD binding site [chemical binding]; other site 279010011708 sugar binding site [chemical binding]; other site 279010011709 divalent metal binding site [ion binding]; other site 279010011710 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010011711 dimer interface [polypeptide binding]; other site 279010011712 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 279010011713 methionine cluster; other site 279010011714 active site 279010011715 phosphorylation site [posttranslational modification] 279010011716 metal binding site [ion binding]; metal-binding site 279010011717 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010011718 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 279010011719 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010011720 active site 279010011721 P-loop; other site 279010011722 phosphorylation site [posttranslational modification] 279010011723 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010011724 HTH domain; Region: HTH_11; pfam08279 279010011725 Mga helix-turn-helix domain; Region: Mga; pfam05043 279010011726 PRD domain; Region: PRD; pfam00874 279010011727 PRD domain; Region: PRD; pfam00874 279010011728 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010011729 active site 279010011730 P-loop; other site 279010011731 phosphorylation site [posttranslational modification] 279010011732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010011733 active site 279010011734 phosphorylation site [posttranslational modification] 279010011735 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 279010011736 active site 279010011737 DNA binding site [nucleotide binding] 279010011738 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010011739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010011740 DNA-binding site [nucleotide binding]; DNA binding site 279010011741 FCD domain; Region: FCD; pfam07729 279010011742 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 279010011743 dimer interface [polypeptide binding]; other site 279010011744 Citrate synthase; Region: Citrate_synt; pfam00285 279010011745 active site 279010011746 coenzyme A binding site [chemical binding]; other site 279010011747 citrylCoA binding site [chemical binding]; other site 279010011748 oxalacetate/citrate binding site [chemical binding]; other site 279010011749 catalytic triad [active] 279010011750 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 279010011751 2-methylcitrate dehydratase; Region: prpD; TIGR02330 279010011752 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 279010011753 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 279010011754 tetramer interface [polypeptide binding]; other site 279010011755 active site 279010011756 Mg2+/Mn2+ binding site [ion binding]; other site 279010011757 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 279010011758 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 279010011759 Chromate transporter; Region: Chromate_transp; pfam02417 279010011760 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010011761 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 279010011762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010011763 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010011764 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 279010011765 Walker A/P-loop; other site 279010011766 ATP binding site [chemical binding]; other site 279010011767 Q-loop/lid; other site 279010011768 ABC transporter signature motif; other site 279010011769 Walker B; other site 279010011770 D-loop; other site 279010011771 H-loop/switch region; other site 279010011772 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010011773 active site 279010011774 catalytic triad [active] 279010011775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011776 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 279010011777 putative substrate translocation pore; other site 279010011778 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 279010011779 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010011780 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010011781 Walker A/P-loop; other site 279010011782 ATP binding site [chemical binding]; other site 279010011783 Q-loop/lid; other site 279010011784 ABC transporter signature motif; other site 279010011785 Walker B; other site 279010011786 D-loop; other site 279010011787 H-loop/switch region; other site 279010011788 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010011789 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 279010011790 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 279010011791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010011792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010011793 DNA binding residues [nucleotide binding] 279010011794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010011796 putative substrate translocation pore; other site 279010011797 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 279010011798 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 279010011799 tetramer interface [polypeptide binding]; other site 279010011800 heme binding pocket [chemical binding]; other site 279010011801 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 279010011802 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 279010011803 tetramer interface [polypeptide binding]; other site 279010011804 heme binding pocket [chemical binding]; other site 279010011805 NADPH binding site [chemical binding]; other site 279010011806 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010011807 metal binding site 2 [ion binding]; metal-binding site 279010011808 putative DNA binding helix; other site 279010011809 metal binding site 1 [ion binding]; metal-binding site 279010011810 dimer interface [polypeptide binding]; other site 279010011811 structural Zn2+ binding site [ion binding]; other site 279010011812 ferrochelatase; Provisional; Region: PRK12435 279010011813 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 279010011814 C-terminal domain interface [polypeptide binding]; other site 279010011815 active site 279010011816 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 279010011817 active site 279010011818 N-terminal domain interface [polypeptide binding]; other site 279010011819 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 279010011820 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010011821 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010011822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010011823 Walker A/P-loop; other site 279010011824 ATP binding site [chemical binding]; other site 279010011825 Q-loop/lid; other site 279010011826 ABC transporter signature motif; other site 279010011827 Walker B; other site 279010011828 D-loop; other site 279010011829 H-loop/switch region; other site 279010011830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 279010011831 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010011832 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010011833 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279010011834 Walker A/P-loop; other site 279010011835 ATP binding site [chemical binding]; other site 279010011836 Q-loop/lid; other site 279010011837 ABC transporter signature motif; other site 279010011838 Walker B; other site 279010011839 D-loop; other site 279010011840 H-loop/switch region; other site 279010011841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010011842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010011843 salt bridge; other site 279010011844 non-specific DNA binding site [nucleotide binding]; other site 279010011845 sequence-specific DNA binding site [nucleotide binding]; other site 279010011846 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 279010011847 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 279010011848 active site 279010011849 catalytic residues [active] 279010011850 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 279010011851 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 279010011852 putative active site [active] 279010011853 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010011854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010011855 Walker A/P-loop; other site 279010011856 ATP binding site [chemical binding]; other site 279010011857 Q-loop/lid; other site 279010011858 ABC transporter signature motif; other site 279010011859 Walker B; other site 279010011860 D-loop; other site 279010011861 H-loop/switch region; other site 279010011862 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 279010011863 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 279010011864 active site 279010011865 zinc binding site [ion binding]; other site 279010011866 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 279010011867 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 279010011868 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 279010011869 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 279010011870 active site 279010011871 zinc binding site [ion binding]; other site 279010011872 Amb_all domain; Region: Amb_all; smart00656 279010011873 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 279010011874 putative substrate binding site [chemical binding]; other site 279010011875 putative ATP binding site [chemical binding]; other site 279010011876 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 279010011877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010011878 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 279010011879 Walker A/P-loop; other site 279010011880 ATP binding site [chemical binding]; other site 279010011881 Q-loop/lid; other site 279010011882 ABC transporter signature motif; other site 279010011883 Walker B; other site 279010011884 D-loop; other site 279010011885 H-loop/switch region; other site 279010011886 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 279010011887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279010011888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010011889 Walker A/P-loop; other site 279010011890 ATP binding site [chemical binding]; other site 279010011891 Q-loop/lid; other site 279010011892 ABC transporter signature motif; other site 279010011893 Walker B; other site 279010011894 D-loop; other site 279010011895 H-loop/switch region; other site 279010011896 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 279010011897 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 279010011898 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 279010011899 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 279010011900 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 279010011901 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 279010011902 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 279010011903 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010011904 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 279010011905 NAD(P) binding pocket [chemical binding]; other site 279010011906 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 279010011907 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 279010011908 Aspartase; Region: Aspartase; cd01357 279010011909 active sites [active] 279010011910 tetramer interface [polypeptide binding]; other site 279010011911 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 279010011912 active site 279010011913 homodimer interface [polypeptide binding]; other site 279010011914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010011915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010011916 non-specific DNA binding site [nucleotide binding]; other site 279010011917 salt bridge; other site 279010011918 sequence-specific DNA binding site [nucleotide binding]; other site 279010011919 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 279010011920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010011921 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 279010011922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011923 ATP binding site [chemical binding]; other site 279010011924 Mg2+ binding site [ion binding]; other site 279010011925 G-X-G motif; other site 279010011926 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010011927 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279010011928 Walker A/P-loop; other site 279010011929 ATP binding site [chemical binding]; other site 279010011930 Q-loop/lid; other site 279010011931 ABC transporter signature motif; other site 279010011932 Walker B; other site 279010011933 D-loop; other site 279010011934 H-loop/switch region; other site 279010011935 FtsX-like permease family; Region: FtsX; pfam02687 279010011936 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010011937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 279010011938 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279010011939 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 279010011940 putative active site [active] 279010011941 putative metal binding site [ion binding]; other site 279010011942 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 279010011943 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 279010011944 DXD motif; other site 279010011945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 279010011946 PilZ domain; Region: PilZ; pfam07238 279010011947 PilZ domain; Region: PilZ; pfam07238 279010011948 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 279010011949 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279010011950 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010011951 active site 279010011952 catalytic site [active] 279010011953 Excalibur calcium-binding domain; Region: Excalibur; cl05460 279010011954 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010011955 Sulfatase; Region: Sulfatase; pfam00884 279010011956 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010011957 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010011958 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010011959 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279010011960 Arginine repressor [Transcription]; Region: ArgR; COG1438 279010011961 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 279010011962 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 279010011963 arginine deiminase; Provisional; Region: PRK01388 279010011964 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 279010011965 ornithine carbamoyltransferase; Validated; Region: PRK02102 279010011966 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279010011967 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 279010011968 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 279010011969 carbamate kinase; Reviewed; Region: PRK12686 279010011970 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 279010011971 putative substrate binding site [chemical binding]; other site 279010011972 nucleotide binding site [chemical binding]; other site 279010011973 nucleotide binding site [chemical binding]; other site 279010011974 homodimer interface [polypeptide binding]; other site 279010011975 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 279010011976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279010011977 ligand binding site [chemical binding]; other site 279010011978 flexible hinge region; other site 279010011979 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 279010011980 putative switch regulator; other site 279010011981 non-specific DNA interactions [nucleotide binding]; other site 279010011982 DNA binding site [nucleotide binding] 279010011983 sequence specific DNA binding site [nucleotide binding]; other site 279010011984 putative cAMP binding site [chemical binding]; other site 279010011985 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 279010011986 beta-galactosidase; Region: BGL; TIGR03356 279010011987 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 279010011988 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010011989 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 279010011990 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 279010011991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010011992 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010011993 DNA binding residues [nucleotide binding] 279010011994 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 279010011995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010011996 FeS/SAM binding site; other site 279010011997 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 279010011998 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 279010011999 hypothetical protein; Provisional; Region: PHA02943 279010012000 Ycf46; Provisional; Region: ycf46; CHL00195 279010012001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010012002 Walker A motif; other site 279010012003 ATP binding site [chemical binding]; other site 279010012004 Walker B motif; other site 279010012005 arginine finger; other site 279010012006 peptidase T; Region: peptidase-T; TIGR01882 279010012007 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 279010012008 metal binding site [ion binding]; metal-binding site 279010012009 dimer interface [polypeptide binding]; other site 279010012010 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 279010012011 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010012012 substrate binding [chemical binding]; other site 279010012013 active site 279010012014 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010012015 galactoside permease; Reviewed; Region: lacY; PRK09528 279010012016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012017 putative substrate translocation pore; other site 279010012018 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010012019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010012020 dimer interface [polypeptide binding]; other site 279010012021 conserved gate region; other site 279010012022 putative PBP binding loops; other site 279010012023 ABC-ATPase subunit interface; other site 279010012024 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010012025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 279010012026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010012027 putative PBP binding loops; other site 279010012028 dimer interface [polypeptide binding]; other site 279010012029 ABC-ATPase subunit interface; other site 279010012030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010012031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010012032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010012033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010012034 DNA binding site [nucleotide binding] 279010012035 domain linker motif; other site 279010012036 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 279010012037 dimerization interface [polypeptide binding]; other site 279010012038 ligand binding site [chemical binding]; other site 279010012039 sodium binding site [ion binding]; other site 279010012040 Chorismate lyase; Region: Chor_lyase; cl01230 279010012041 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010012042 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 279010012043 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 279010012044 substrate binding site [chemical binding]; other site 279010012045 THF binding site; other site 279010012046 zinc-binding site [ion binding]; other site 279010012047 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 279010012048 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 279010012049 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 279010012050 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279010012051 Ligand binding site; other site 279010012052 Putative Catalytic site; other site 279010012053 DXD motif; other site 279010012054 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010012055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010012056 NAD(P) binding site [chemical binding]; other site 279010012057 active site 279010012058 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 279010012059 PGAP1-like protein; Region: PGAP1; pfam07819 279010012060 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 279010012061 nucleoside transporter; Region: nupC; TIGR00804 279010012062 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279010012063 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279010012064 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010012065 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 279010012066 beta-galactosidase; Region: BGL; TIGR03356 279010012067 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 279010012068 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010012069 active site turn [active] 279010012070 phosphorylation site [posttranslational modification] 279010012071 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010012072 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 279010012073 HPr interaction site; other site 279010012074 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010012075 active site 279010012076 phosphorylation site [posttranslational modification] 279010012077 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010012078 CAT RNA binding domain; Region: CAT_RBD; smart01061 279010012079 PRD domain; Region: PRD; pfam00874 279010012080 PRD domain; Region: PRD; pfam00874 279010012081 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 279010012082 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 279010012083 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279010012084 Walker A/P-loop; other site 279010012085 ATP binding site [chemical binding]; other site 279010012086 Q-loop/lid; other site 279010012087 ABC transporter signature motif; other site 279010012088 Walker B; other site 279010012089 D-loop; other site 279010012090 H-loop/switch region; other site 279010012091 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279010012092 Walker A/P-loop; other site 279010012093 ATP binding site [chemical binding]; other site 279010012094 Q-loop/lid; other site 279010012095 ABC transporter signature motif; other site 279010012096 Walker B; other site 279010012097 D-loop; other site 279010012098 H-loop/switch region; other site 279010012099 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 279010012100 Putative transcription activator [Transcription]; Region: TenA; COG0819 279010012101 isocitrate lyase; Provisional; Region: PRK15063 279010012102 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 279010012103 tetramer interface [polypeptide binding]; other site 279010012104 active site 279010012105 Mg2+/Mn2+ binding site [ion binding]; other site 279010012106 malate synthase A; Region: malate_syn_A; TIGR01344 279010012107 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 279010012108 active site 279010012109 YhfH-like protein; Region: YhfH; pfam14149 279010012110 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 279010012111 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 279010012112 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 279010012113 FtsX-like permease family; Region: FtsX; pfam02687 279010012114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010012115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279010012116 Walker A/P-loop; other site 279010012117 ATP binding site [chemical binding]; other site 279010012118 Q-loop/lid; other site 279010012119 ABC transporter signature motif; other site 279010012120 Walker B; other site 279010012121 D-loop; other site 279010012122 H-loop/switch region; other site 279010012123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010012124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010012125 ATP binding site [chemical binding]; other site 279010012126 Mg2+ binding site [ion binding]; other site 279010012127 G-X-G motif; other site 279010012128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010012129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010012130 active site 279010012131 phosphorylation site [posttranslational modification] 279010012132 intermolecular recognition site; other site 279010012133 dimerization interface [polypeptide binding]; other site 279010012134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010012135 DNA binding site [nucleotide binding] 279010012136 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 279010012137 beta-galactosidase; Region: BGL; TIGR03356 279010012138 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 279010012139 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010012140 active site turn [active] 279010012141 phosphorylation site [posttranslational modification] 279010012142 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010012143 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 279010012144 HPr interaction site; other site 279010012145 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010012146 active site 279010012147 phosphorylation site [posttranslational modification] 279010012148 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 279010012149 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 279010012150 active site 279010012151 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 279010012152 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 279010012153 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 279010012154 substrate binding site [chemical binding]; other site 279010012155 active site 279010012156 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 279010012157 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010012158 ATP binding site [chemical binding]; other site 279010012159 Mg++ binding site [ion binding]; other site 279010012160 motif III; other site 279010012161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010012162 nucleotide binding region [chemical binding]; other site 279010012163 ATP-binding site [chemical binding]; other site 279010012164 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 279010012165 RNA binding site [nucleotide binding]; other site 279010012166 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010012167 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 279010012168 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279010012169 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010012170 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 279010012171 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 279010012172 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279010012173 Nucleoside recognition; Region: Gate; pfam07670 279010012174 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279010012175 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 279010012176 intersubunit interface [polypeptide binding]; other site 279010012177 active site 279010012178 catalytic residue [active] 279010012179 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279010012180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 279010012181 DNA binding residues [nucleotide binding] 279010012182 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279010012183 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 279010012184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 279010012185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010012186 metal binding site [ion binding]; metal-binding site 279010012187 active site 279010012188 I-site; other site 279010012189 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 279010012190 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 279010012191 NodB motif; other site 279010012192 putative active site [active] 279010012193 putative catalytic site [active] 279010012194 putative Zn binding site [ion binding]; other site 279010012195 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 279010012196 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 279010012197 DXD motif; other site 279010012198 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 279010012199 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 279010012200 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 279010012201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010012202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010012203 homodimer interface [polypeptide binding]; other site 279010012204 catalytic residue [active] 279010012205 Prephenate dehydratase; Region: PDT; pfam00800 279010012206 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 279010012207 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 279010012208 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 279010012209 EamA-like transporter family; Region: EamA; pfam00892 279010012210 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279010012211 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 279010012212 intersubunit interface [polypeptide binding]; other site 279010012213 active site 279010012214 zinc binding site [ion binding]; other site 279010012215 Na+ binding site [ion binding]; other site 279010012216 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 279010012217 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 279010012218 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 279010012219 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 279010012220 DNA interaction; other site 279010012221 Metal-binding active site; metal-binding site 279010012222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010012223 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279010012224 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 279010012225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012226 putative substrate translocation pore; other site 279010012227 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 279010012228 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 279010012229 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279010012230 PYR/PP interface [polypeptide binding]; other site 279010012231 dimer interface [polypeptide binding]; other site 279010012232 TPP binding site [chemical binding]; other site 279010012233 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279010012234 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 279010012235 TPP-binding site; other site 279010012236 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010012237 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279010012238 substrate binding site [chemical binding]; other site 279010012239 ATP binding site [chemical binding]; other site 279010012240 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 279010012241 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 279010012242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010012243 tetrameric interface [polypeptide binding]; other site 279010012244 NAD binding site [chemical binding]; other site 279010012245 catalytic residues [active] 279010012246 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010012247 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 279010012248 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 279010012249 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010012250 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010012251 active site 279010012252 catalytic tetrad [active] 279010012253 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010012254 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 279010012255 active site 279010012256 catalytic site [active] 279010012257 metal binding site [ion binding]; metal-binding site 279010012258 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 279010012259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012260 putative substrate translocation pore; other site 279010012261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012262 heat shock protein 90; Provisional; Region: PRK05218 279010012263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010012264 ATP binding site [chemical binding]; other site 279010012265 Mg2+ binding site [ion binding]; other site 279010012266 G-X-G motif; other site 279010012267 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010012268 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010012269 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010012270 ABC transporter; Region: ABC_tran_2; pfam12848 279010012271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279010012272 sugar phosphate phosphatase; Provisional; Region: PRK10513 279010012273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010012274 active site 279010012275 motif I; other site 279010012276 motif II; other site 279010012277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010012278 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010012279 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 279010012280 active site 279010012281 metal binding site [ion binding]; metal-binding site 279010012282 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 279010012283 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010012284 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 279010012285 putative ligand binding residues [chemical binding]; other site 279010012286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010012287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 279010012288 active site 279010012289 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 279010012290 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 279010012291 G1 box; other site 279010012292 GTP/Mg2+ binding site [chemical binding]; other site 279010012293 Switch I region; other site 279010012294 G2 box; other site 279010012295 G3 box; other site 279010012296 Switch II region; other site 279010012297 G4 box; other site 279010012298 G5 box; other site 279010012299 Nucleoside recognition; Region: Gate; pfam07670 279010012300 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 279010012301 Nucleoside recognition; Region: Gate; pfam07670 279010012302 FeoA domain; Region: FeoA; pfam04023 279010012303 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 279010012304 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279010012305 FtsX-like permease family; Region: FtsX; pfam02687 279010012306 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010012307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010012308 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279010012309 Walker A/P-loop; other site 279010012310 ATP binding site [chemical binding]; other site 279010012311 Q-loop/lid; other site 279010012312 ABC transporter signature motif; other site 279010012313 Walker B; other site 279010012314 D-loop; other site 279010012315 H-loop/switch region; other site 279010012316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010012317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010012318 dimer interface [polypeptide binding]; other site 279010012319 phosphorylation site [posttranslational modification] 279010012320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010012321 ATP binding site [chemical binding]; other site 279010012322 Mg2+ binding site [ion binding]; other site 279010012323 G-X-G motif; other site 279010012324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010012325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010012326 active site 279010012327 phosphorylation site [posttranslational modification] 279010012328 intermolecular recognition site; other site 279010012329 dimerization interface [polypeptide binding]; other site 279010012330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010012331 DNA binding site [nucleotide binding] 279010012332 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 279010012333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010012334 dimerization interface [polypeptide binding]; other site 279010012335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010012336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010012337 dimer interface [polypeptide binding]; other site 279010012338 putative CheW interface [polypeptide binding]; other site 279010012339 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010012340 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010012341 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 279010012342 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 279010012343 hexamer interface [polypeptide binding]; other site 279010012344 ligand binding site [chemical binding]; other site 279010012345 putative active site [active] 279010012346 NAD(P) binding site [chemical binding]; other site 279010012347 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 279010012348 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 279010012349 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 279010012350 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 279010012351 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 279010012352 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010012353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010012354 dimer interface [polypeptide binding]; other site 279010012355 conserved gate region; other site 279010012356 putative PBP binding loops; other site 279010012357 ABC-ATPase subunit interface; other site 279010012358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010012359 dimer interface [polypeptide binding]; other site 279010012360 conserved gate region; other site 279010012361 ABC-ATPase subunit interface; other site 279010012362 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 279010012363 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 279010012364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010012365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010012366 DNA binding site [nucleotide binding] 279010012367 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 279010012368 putative dimerization interface [polypeptide binding]; other site 279010012369 putative ligand binding site [chemical binding]; other site 279010012370 galactokinase; Provisional; Region: PRK05322 279010012371 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 279010012372 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279010012373 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279010012374 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010012375 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 279010012376 NAD binding site [chemical binding]; other site 279010012377 homodimer interface [polypeptide binding]; other site 279010012378 active site 279010012379 substrate binding site [chemical binding]; other site 279010012380 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 279010012381 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 279010012382 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 279010012383 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 279010012384 non-specific DNA interactions [nucleotide binding]; other site 279010012385 DNA binding site [nucleotide binding] 279010012386 sequence specific DNA binding site [nucleotide binding]; other site 279010012387 putative cAMP binding site [chemical binding]; other site 279010012388 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279010012389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279010012390 nucleotide binding site [chemical binding]; other site 279010012391 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010012392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010012393 DNA-binding site [nucleotide binding]; DNA binding site 279010012394 FCD domain; Region: FCD; pfam07729 279010012395 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 279010012396 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 279010012397 N- and C-terminal domain interface [polypeptide binding]; other site 279010012398 active site 279010012399 catalytic site [active] 279010012400 metal binding site [ion binding]; metal-binding site 279010012401 carbohydrate binding site [chemical binding]; other site 279010012402 ATP binding site [chemical binding]; other site 279010012403 fructuronate transporter; Provisional; Region: PRK10034; cl15264 279010012404 gluconate transporter; Region: gntP; TIGR00791 279010012405 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 279010012406 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 279010012407 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 279010012408 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 279010012409 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 279010012410 putative catalytic cysteine [active] 279010012411 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 279010012412 putative active site [active] 279010012413 metal binding site [ion binding]; metal-binding site 279010012414 peroxiredoxin; Region: AhpC; TIGR03137 279010012415 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 279010012416 dimer interface [polypeptide binding]; other site 279010012417 decamer (pentamer of dimers) interface [polypeptide binding]; other site 279010012418 catalytic triad [active] 279010012419 peroxidatic and resolving cysteines [active] 279010012420 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 279010012421 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 279010012422 catalytic residue [active] 279010012423 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 279010012424 catalytic residues [active] 279010012425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279010012426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010012427 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010012428 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279010012429 Walker A/P-loop; other site 279010012430 ATP binding site [chemical binding]; other site 279010012431 Q-loop/lid; other site 279010012432 ABC transporter signature motif; other site 279010012433 Walker B; other site 279010012434 D-loop; other site 279010012435 H-loop/switch region; other site 279010012436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010012437 Histidine kinase; Region: HisKA_3; pfam07730 279010012438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010012439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010012440 active site 279010012441 phosphorylation site [posttranslational modification] 279010012442 intermolecular recognition site; other site 279010012443 dimerization interface [polypeptide binding]; other site 279010012444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010012445 DNA binding residues [nucleotide binding] 279010012446 dimerization interface [polypeptide binding]; other site 279010012447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279010012448 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 279010012449 Walker A/P-loop; other site 279010012450 ATP binding site [chemical binding]; other site 279010012451 Q-loop/lid; other site 279010012452 ABC transporter signature motif; other site 279010012453 Walker B; other site 279010012454 D-loop; other site 279010012455 H-loop/switch region; other site 279010012456 prophage region BLi_Pp7 279010012457 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 279010012458 DNA binding site [nucleotide binding] 279010012459 Int/Topo IB signature motif; other site 279010012460 active site 279010012461 catalytic residues [active] 279010012462 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 279010012463 active site 279010012464 NTP binding site [chemical binding]; other site 279010012465 metal binding triad [ion binding]; metal-binding site 279010012466 Protein of unknown function DUF45; Region: DUF45; pfam01863 279010012467 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 279010012468 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 279010012469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010012470 ATP binding site [chemical binding]; other site 279010012471 putative Mg++ binding site [ion binding]; other site 279010012472 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 279010012473 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010012474 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 279010012475 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010012476 Virulence protein [General function prediction only]; Region: COG3943 279010012477 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 279010012478 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 279010012479 HsdM N-terminal domain; Region: HsdM_N; pfam12161 279010012480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 279010012481 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279010012482 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279010012483 catalytic nucleophile [active] 279010012484 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279010012485 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 279010012486 Recombinase; Region: Recombinase; pfam07508 279010012487 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 279010012488 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279010012489 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279010012490 catalytic residues [active] 279010012491 catalytic nucleophile [active] 279010012492 Recombinase; Region: Recombinase; pfam07508 279010012493 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 279010012494 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 279010012495 YyzF-like protein; Region: YyzF; pfam14116 279010012496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010012497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010012498 Coenzyme A binding pocket [chemical binding]; other site 279010012499 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 279010012500 Uncharacterized conserved protein [Function unknown]; Region: COG1912 279010012501 serine endoprotease; Provisional; Region: PRK10898 279010012502 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279010012503 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010012504 protein binding site [polypeptide binding]; other site 279010012505 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 279010012506 YycH protein; Region: YycI; cl02015 279010012507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 279010012508 YycH protein; Region: YycH; pfam07435 279010012509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 279010012510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010012511 dimerization interface [polypeptide binding]; other site 279010012512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010012513 putative active site [active] 279010012514 heme pocket [chemical binding]; other site 279010012515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010012516 dimer interface [polypeptide binding]; other site 279010012517 phosphorylation site [posttranslational modification] 279010012518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010012519 ATP binding site [chemical binding]; other site 279010012520 Mg2+ binding site [ion binding]; other site 279010012521 G-X-G motif; other site 279010012522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010012523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010012524 active site 279010012525 phosphorylation site [posttranslational modification] 279010012526 intermolecular recognition site; other site 279010012527 dimerization interface [polypeptide binding]; other site 279010012528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010012529 DNA binding site [nucleotide binding] 279010012530 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 279010012531 nudix motif; other site 279010012532 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 279010012533 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 279010012534 GDP-binding site [chemical binding]; other site 279010012535 ACT binding site; other site 279010012536 IMP binding site; other site 279010012537 replicative DNA helicase; Provisional; Region: PRK05748 279010012538 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 279010012539 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 279010012540 Walker A motif; other site 279010012541 ATP binding site [chemical binding]; other site 279010012542 Walker B motif; other site 279010012543 DNA binding loops [nucleotide binding] 279010012544 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 279010012545 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 279010012546 YycC-like protein; Region: YycC; pfam14174 279010012547 cyanate transporter; Region: CynX; TIGR00896 279010012548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012549 putative substrate translocation pore; other site 279010012550 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 279010012551 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 279010012552 active site 279010012553 dimer interface [polypeptide binding]; other site 279010012554 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 279010012555 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 279010012556 active site 279010012557 trimer interface [polypeptide binding]; other site 279010012558 allosteric site; other site 279010012559 active site lid [active] 279010012560 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010012561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010012562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010012563 DNA-binding site [nucleotide binding]; DNA binding site 279010012564 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 279010012565 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 279010012566 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 279010012567 putative active site [active] 279010012568 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 279010012569 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279010012570 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010012571 active site turn [active] 279010012572 phosphorylation site [posttranslational modification] 279010012573 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 279010012574 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 279010012575 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 279010012576 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 279010012577 diguanylate cyclase; Region: GGDEF; smart00267 279010012578 DHH family; Region: DHH; pfam01368 279010012579 DHHA1 domain; Region: DHHA1; pfam02272 279010012580 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 279010012581 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 279010012582 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 279010012583 Ligand Binding Site [chemical binding]; other site 279010012584 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 279010012585 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 279010012586 Sulfate transporter family; Region: Sulfate_transp; pfam00916 279010012587 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 279010012588 D-galactonate transporter; Region: 2A0114; TIGR00893 279010012589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012590 putative substrate translocation pore; other site 279010012591 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 279010012592 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279010012593 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279010012594 dimer interface [polypeptide binding]; other site 279010012595 ssDNA binding site [nucleotide binding]; other site 279010012596 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010012597 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 279010012598 GTP-binding protein YchF; Reviewed; Region: PRK09601 279010012599 YchF GTPase; Region: YchF; cd01900 279010012600 G1 box; other site 279010012601 GTP/Mg2+ binding site [chemical binding]; other site 279010012602 Switch I region; other site 279010012603 G2 box; other site 279010012604 Switch II region; other site 279010012605 G3 box; other site 279010012606 G4 box; other site 279010012607 G5 box; other site 279010012608 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 279010012609 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 279010012610 Uncharacterized membrane protein [Function unknown]; Region: COG3949 279010012611 Spore germination protein; Region: Spore_permease; cl17796 279010012612 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 279010012613 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 279010012614 ParB-like nuclease domain; Region: ParB; smart00470 279010012615 KorB domain; Region: KorB; pfam08535 279010012616 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 279010012617 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 279010012618 P-loop; other site 279010012619 Magnesium ion binding site [ion binding]; other site 279010012620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 279010012621 Magnesium ion binding site [ion binding]; other site 279010012622 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 279010012623 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 279010012624 Uncharacterized conserved protein [Function unknown]; Region: COG2128 279010012625 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 279010012626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010012627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010012628 DNA binding residues [nucleotide binding] 279010012629 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 279010012630 ParB-like nuclease domain; Region: ParB; smart00470 279010012631 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 279010012632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010012633 S-adenosylmethionine binding site [chemical binding]; other site 279010012634 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 279010012635 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 279010012636 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 279010012637 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 279010012638 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 279010012639 trmE is a tRNA modification GTPase; Region: trmE; cd04164 279010012640 G1 box; other site 279010012641 GTP/Mg2+ binding site [chemical binding]; other site 279010012642 Switch I region; other site 279010012643 G2 box; other site 279010012644 Switch II region; other site 279010012645 G3 box; other site 279010012646 G4 box; other site 279010012647 G5 box; other site 279010012648 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 279010012649 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 279010012650 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 279010012651 G-X-X-G motif; other site 279010012652 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 279010012653 RxxxH motif; other site 279010012654 OxaA-like protein precursor; Validated; Region: PRK02944 279010012655 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 279010012656 ribonuclease P; Reviewed; Region: rnpA; PRK00499 279010012657 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399