-- dump date 20140618_223015 -- class Genbank::misc_feature -- table misc_feature_note -- id note 592022000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 592022000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 592022000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022000004 Walker A motif; other site 592022000005 ATP binding site [chemical binding]; other site 592022000006 Walker B motif; other site 592022000007 arginine finger; other site 592022000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 592022000009 DnaA box-binding interface [nucleotide binding]; other site 592022000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 592022000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 592022000012 putative DNA binding surface [nucleotide binding]; other site 592022000013 dimer interface [polypeptide binding]; other site 592022000014 beta-clamp/clamp loader binding surface; other site 592022000015 beta-clamp/translesion DNA polymerase binding surface; other site 592022000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 592022000017 recombination protein F; Reviewed; Region: recF; PRK00064 592022000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 592022000019 Walker A/P-loop; other site 592022000020 ATP binding site [chemical binding]; other site 592022000021 Q-loop/lid; other site 592022000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022000023 ABC transporter signature motif; other site 592022000024 Walker B; other site 592022000025 D-loop; other site 592022000026 H-loop/switch region; other site 592022000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 592022000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022000029 Mg2+ binding site [ion binding]; other site 592022000030 G-X-G motif; other site 592022000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 592022000032 anchoring element; other site 592022000033 dimer interface [polypeptide binding]; other site 592022000034 ATP binding site [chemical binding]; other site 592022000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 592022000036 active site 592022000037 putative metal-binding site [ion binding]; other site 592022000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592022000039 DNA gyrase subunit A; Validated; Region: PRK05560 592022000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 592022000041 CAP-like domain; other site 592022000042 active site 592022000043 primary dimer interface [polypeptide binding]; other site 592022000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022000050 YaaC-like Protein; Region: YaaC; pfam14175 592022000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 592022000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592022000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 592022000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 592022000055 active site 592022000056 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592022000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 592022000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 592022000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 592022000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 592022000061 active site 592022000062 multimer interface [polypeptide binding]; other site 592022000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 592022000064 predicted active site [active] 592022000065 catalytic triad [active] 592022000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 592022000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 592022000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 592022000069 dimer interface [polypeptide binding]; other site 592022000070 active site 592022000071 motif 1; other site 592022000072 motif 2; other site 592022000073 motif 3; other site 592022000074 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 592022000075 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 592022000076 Substrate-binding site [chemical binding]; other site 592022000077 Substrate specificity [chemical binding]; other site 592022000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 592022000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 592022000080 Substrate-binding site [chemical binding]; other site 592022000081 Substrate specificity [chemical binding]; other site 592022000082 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 592022000083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022000084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022000085 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 592022000086 active site 592022000087 Isochorismatase family; Region: Isochorismatase; pfam00857 592022000088 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592022000089 catalytic triad [active] 592022000090 conserved cis-peptide bond; other site 592022000091 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 592022000092 nucleoside/Zn binding site; other site 592022000093 dimer interface [polypeptide binding]; other site 592022000094 catalytic motif [active] 592022000095 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 592022000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022000097 Walker A motif; other site 592022000098 ATP binding site [chemical binding]; other site 592022000099 Walker B motif; other site 592022000100 arginine finger; other site 592022000101 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 592022000102 hypothetical protein; Validated; Region: PRK00153 592022000103 recombination protein RecR; Reviewed; Region: recR; PRK00076 592022000104 RecR protein; Region: RecR; pfam02132 592022000105 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 592022000106 putative active site [active] 592022000107 putative metal-binding site [ion binding]; other site 592022000108 tetramer interface [polypeptide binding]; other site 592022000109 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 592022000110 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 592022000111 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 592022000112 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 592022000113 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 592022000114 homodimer interface [polypeptide binding]; other site 592022000115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022000116 catalytic residue [active] 592022000117 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 592022000118 thymidylate kinase; Validated; Region: tmk; PRK00698 592022000119 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 592022000120 TMP-binding site; other site 592022000121 ATP-binding site [chemical binding]; other site 592022000122 Protein of unknown function (DUF970); Region: DUF970; pfam06153 592022000123 DNA polymerase III subunit delta'; Validated; Region: PRK08058 592022000124 DNA polymerase III subunit delta'; Validated; Region: PRK08485 592022000125 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 592022000126 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 592022000127 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 592022000128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022000129 S-adenosylmethionine binding site [chemical binding]; other site 592022000130 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 592022000131 GIY-YIG motif/motif A; other site 592022000132 putative active site [active] 592022000133 putative metal binding site [ion binding]; other site 592022000134 Predicted methyltransferases [General function prediction only]; Region: COG0313 592022000135 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 592022000136 putative SAM binding site [chemical binding]; other site 592022000137 putative homodimer interface [polypeptide binding]; other site 592022000138 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 592022000139 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 592022000140 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 592022000141 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 592022000142 active site 592022000143 HIGH motif; other site 592022000144 KMSKS motif; other site 592022000145 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 592022000146 tRNA binding surface [nucleotide binding]; other site 592022000147 anticodon binding site; other site 592022000148 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 592022000149 dimer interface [polypeptide binding]; other site 592022000150 putative tRNA-binding site [nucleotide binding]; other site 592022000151 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 592022000152 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592022000153 active site 592022000154 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 592022000155 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 592022000156 putative active site [active] 592022000157 putative metal binding site [ion binding]; other site 592022000158 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 592022000159 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 592022000160 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 592022000161 YabG peptidase U57; Region: Peptidase_U57; pfam05582 592022000162 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 592022000163 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022000164 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 592022000165 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592022000166 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 592022000167 pur operon repressor; Provisional; Region: PRK09213 592022000168 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 592022000169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022000170 active site 592022000171 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592022000172 homotrimer interaction site [polypeptide binding]; other site 592022000173 putative active site [active] 592022000174 regulatory protein SpoVG; Reviewed; Region: PRK13259 592022000175 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 592022000176 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 592022000177 Substrate binding site; other site 592022000178 Mg++ binding site; other site 592022000179 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 592022000180 active site 592022000181 substrate binding site [chemical binding]; other site 592022000182 CoA binding site [chemical binding]; other site 592022000183 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 592022000184 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 592022000185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022000186 active site 592022000187 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 592022000188 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 592022000189 5S rRNA interface [nucleotide binding]; other site 592022000190 CTC domain interface [polypeptide binding]; other site 592022000191 L16 interface [polypeptide binding]; other site 592022000192 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 592022000193 putative active site [active] 592022000194 catalytic residue [active] 592022000195 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 592022000196 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 592022000197 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 592022000198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022000199 ATP binding site [chemical binding]; other site 592022000200 putative Mg++ binding site [ion binding]; other site 592022000201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022000202 nucleotide binding region [chemical binding]; other site 592022000203 ATP-binding site [chemical binding]; other site 592022000204 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 592022000205 stage V sporulation protein T; Region: spore_V_T; TIGR02851 592022000206 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 592022000207 GAF domain; Region: GAF; cl17456 592022000208 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 592022000209 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 592022000210 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 592022000211 putative SAM binding site [chemical binding]; other site 592022000212 putative homodimer interface [polypeptide binding]; other site 592022000213 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 592022000214 homodimer interface [polypeptide binding]; other site 592022000215 metal binding site [ion binding]; metal-binding site 592022000216 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 592022000217 homodimer interface [polypeptide binding]; other site 592022000218 active site 592022000219 putative chemical substrate binding site [chemical binding]; other site 592022000220 metal binding site [ion binding]; metal-binding site 592022000221 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022000222 RNA binding surface [nucleotide binding]; other site 592022000223 sporulation protein YabP; Region: spore_yabP; TIGR02892 592022000224 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 592022000225 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 592022000226 Septum formation initiator; Region: DivIC; cl17659 592022000227 hypothetical protein; Provisional; Region: PRK08582 592022000228 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 592022000229 RNA binding site [nucleotide binding]; other site 592022000230 stage II sporulation protein E; Region: spore_II_E; TIGR02865 592022000231 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 592022000232 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 592022000233 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 592022000234 metal ion-dependent adhesion site (MIDAS); other site 592022000235 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 592022000236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 592022000237 active site 592022000238 ATP binding site [chemical binding]; other site 592022000239 substrate binding site [chemical binding]; other site 592022000240 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 592022000241 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 592022000242 Ligand Binding Site [chemical binding]; other site 592022000243 TilS substrate C-terminal domain; Region: TilS_C; smart00977 592022000244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022000245 active site 592022000246 FtsH Extracellular; Region: FtsH_ext; pfam06480 592022000247 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 592022000248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022000249 Walker A motif; other site 592022000250 ATP binding site [chemical binding]; other site 592022000251 Walker B motif; other site 592022000252 arginine finger; other site 592022000253 Peptidase family M41; Region: Peptidase_M41; pfam01434 592022000254 pantothenate kinase; Reviewed; Region: PRK13318 592022000255 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 592022000256 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 592022000257 dimerization interface [polypeptide binding]; other site 592022000258 domain crossover interface; other site 592022000259 redox-dependent activation switch; other site 592022000260 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592022000261 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592022000262 dimer interface [polypeptide binding]; other site 592022000263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022000264 catalytic residue [active] 592022000265 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 592022000266 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592022000267 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592022000268 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 592022000269 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 592022000270 glutamine binding [chemical binding]; other site 592022000271 catalytic triad [active] 592022000272 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592022000273 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 592022000274 homodimer interface [polypeptide binding]; other site 592022000275 substrate-cofactor binding pocket; other site 592022000276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022000277 catalytic residue [active] 592022000278 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 592022000279 homooctamer interface [polypeptide binding]; other site 592022000280 active site 592022000281 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 592022000282 catalytic center binding site [active] 592022000283 ATP binding site [chemical binding]; other site 592022000284 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 592022000285 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 592022000286 dimer interface [polypeptide binding]; other site 592022000287 putative anticodon binding site; other site 592022000288 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 592022000289 motif 1; other site 592022000290 active site 592022000291 motif 2; other site 592022000292 motif 3; other site 592022000293 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 592022000294 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 592022000295 UvrB/uvrC motif; Region: UVR; pfam02151 592022000296 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 592022000297 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 592022000298 ADP binding site [chemical binding]; other site 592022000299 phosphagen binding site; other site 592022000300 substrate specificity loop; other site 592022000301 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 592022000302 Clp amino terminal domain; Region: Clp_N; pfam02861 592022000303 Clp amino terminal domain; Region: Clp_N; pfam02861 592022000304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022000305 Walker A motif; other site 592022000306 ATP binding site [chemical binding]; other site 592022000307 Walker B motif; other site 592022000308 arginine finger; other site 592022000309 UvrB/uvrC motif; Region: UVR; pfam02151 592022000310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022000311 Walker A motif; other site 592022000312 ATP binding site [chemical binding]; other site 592022000313 Walker B motif; other site 592022000314 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592022000315 DNA repair protein RadA; Provisional; Region: PRK11823 592022000316 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 592022000317 Walker A motif/ATP binding site; other site 592022000318 ATP binding site [chemical binding]; other site 592022000319 Walker B motif; other site 592022000320 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 592022000321 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 592022000322 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 592022000323 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 592022000324 Helix-hairpin-helix motif; Region: HHH; pfam00633 592022000325 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 592022000326 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 592022000327 putative active site [active] 592022000328 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 592022000329 substrate binding site; other site 592022000330 dimer interface; other site 592022000331 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 592022000332 homotrimer interaction site [polypeptide binding]; other site 592022000333 zinc binding site [ion binding]; other site 592022000334 CDP-binding sites; other site 592022000335 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 592022000336 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592022000337 active site 592022000338 HIGH motif; other site 592022000339 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592022000340 active site 592022000341 KMSKS motif; other site 592022000342 serine O-acetyltransferase; Region: cysE; TIGR01172 592022000343 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 592022000344 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 592022000345 trimer interface [polypeptide binding]; other site 592022000346 active site 592022000347 substrate binding site [chemical binding]; other site 592022000348 CoA binding site [chemical binding]; other site 592022000349 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 592022000350 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592022000351 active site 592022000352 HIGH motif; other site 592022000353 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592022000354 KMSKS motif; other site 592022000355 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 592022000356 tRNA binding surface [nucleotide binding]; other site 592022000357 anticodon binding site; other site 592022000358 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 592022000359 active site 592022000360 metal binding site [ion binding]; metal-binding site 592022000361 dimerization interface [polypeptide binding]; other site 592022000362 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 592022000363 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 592022000364 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592022000365 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 592022000366 RNA polymerase factor sigma-70; Validated; Region: PRK08295 592022000367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022000368 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 592022000369 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 592022000370 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 592022000371 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 592022000372 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 592022000373 putative homodimer interface [polypeptide binding]; other site 592022000374 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 592022000375 heterodimer interface [polypeptide binding]; other site 592022000376 homodimer interface [polypeptide binding]; other site 592022000377 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 592022000378 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 592022000379 23S rRNA interface [nucleotide binding]; other site 592022000380 L7/L12 interface [polypeptide binding]; other site 592022000381 putative thiostrepton binding site; other site 592022000382 L25 interface [polypeptide binding]; other site 592022000383 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 592022000384 mRNA/rRNA interface [nucleotide binding]; other site 592022000385 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 592022000386 23S rRNA interface [nucleotide binding]; other site 592022000387 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 592022000388 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 592022000389 peripheral dimer interface [polypeptide binding]; other site 592022000390 core dimer interface [polypeptide binding]; other site 592022000391 L10 interface [polypeptide binding]; other site 592022000392 L11 interface [polypeptide binding]; other site 592022000393 putative EF-Tu interaction site [polypeptide binding]; other site 592022000394 putative EF-G interaction site [polypeptide binding]; other site 592022000395 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 592022000396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022000397 S-adenosylmethionine binding site [chemical binding]; other site 592022000398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 592022000399 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 592022000400 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 592022000401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592022000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592022000403 RPB10 interaction site [polypeptide binding]; other site 592022000404 RPB1 interaction site [polypeptide binding]; other site 592022000405 RPB11 interaction site [polypeptide binding]; other site 592022000406 RPB3 interaction site [polypeptide binding]; other site 592022000407 RPB12 interaction site [polypeptide binding]; other site 592022000408 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 592022000409 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 592022000410 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 592022000411 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 592022000412 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 592022000413 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 592022000414 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 592022000415 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 592022000416 G-loop; other site 592022000417 DNA binding site [nucleotide binding] 592022000418 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 592022000419 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 592022000420 S17 interaction site [polypeptide binding]; other site 592022000421 S8 interaction site; other site 592022000422 16S rRNA interaction site [nucleotide binding]; other site 592022000423 streptomycin interaction site [chemical binding]; other site 592022000424 23S rRNA interaction site [nucleotide binding]; other site 592022000425 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 592022000426 30S ribosomal protein S7; Validated; Region: PRK05302 592022000427 elongation factor G; Reviewed; Region: PRK00007 592022000428 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 592022000429 G1 box; other site 592022000430 putative GEF interaction site [polypeptide binding]; other site 592022000431 GTP/Mg2+ binding site [chemical binding]; other site 592022000432 Switch I region; other site 592022000433 G2 box; other site 592022000434 G3 box; other site 592022000435 Switch II region; other site 592022000436 G4 box; other site 592022000437 G5 box; other site 592022000438 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 592022000439 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 592022000440 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 592022000441 elongation factor Tu; Reviewed; Region: PRK00049 592022000442 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 592022000443 G1 box; other site 592022000444 GEF interaction site [polypeptide binding]; other site 592022000445 GTP/Mg2+ binding site [chemical binding]; other site 592022000446 Switch I region; other site 592022000447 G2 box; other site 592022000448 G3 box; other site 592022000449 Switch II region; other site 592022000450 G4 box; other site 592022000451 G5 box; other site 592022000452 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 592022000453 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 592022000454 Antibiotic Binding Site [chemical binding]; other site 592022000455 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 592022000456 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 592022000457 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 592022000458 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 592022000459 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 592022000460 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 592022000461 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 592022000462 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 592022000463 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 592022000464 putative translocon binding site; other site 592022000465 protein-rRNA interface [nucleotide binding]; other site 592022000466 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 592022000467 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 592022000468 G-X-X-G motif; other site 592022000469 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 592022000470 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 592022000471 23S rRNA interface [nucleotide binding]; other site 592022000472 5S rRNA interface [nucleotide binding]; other site 592022000473 putative antibiotic binding site [chemical binding]; other site 592022000474 L25 interface [polypeptide binding]; other site 592022000475 L27 interface [polypeptide binding]; other site 592022000476 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 592022000477 23S rRNA interface [nucleotide binding]; other site 592022000478 putative translocon interaction site; other site 592022000479 signal recognition particle (SRP54) interaction site; other site 592022000480 L23 interface [polypeptide binding]; other site 592022000481 trigger factor interaction site; other site 592022000482 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 592022000483 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 592022000484 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 592022000485 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 592022000486 RNA binding site [nucleotide binding]; other site 592022000487 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 592022000488 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 592022000489 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 592022000490 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 592022000491 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 592022000492 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 592022000493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592022000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592022000495 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 592022000496 23S rRNA interface [nucleotide binding]; other site 592022000497 5S rRNA interface [nucleotide binding]; other site 592022000498 L27 interface [polypeptide binding]; other site 592022000499 L5 interface [polypeptide binding]; other site 592022000500 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 592022000501 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 592022000502 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 592022000503 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 592022000504 23S rRNA binding site [nucleotide binding]; other site 592022000505 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 592022000506 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 592022000507 SecY translocase; Region: SecY; pfam00344 592022000508 adenylate kinase; Reviewed; Region: adk; PRK00279 592022000509 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 592022000510 AMP-binding site [chemical binding]; other site 592022000511 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 592022000512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592022000513 active site 592022000514 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 592022000515 rRNA binding site [nucleotide binding]; other site 592022000516 predicted 30S ribosome binding site; other site 592022000517 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 592022000518 30S ribosomal protein S13; Region: bact_S13; TIGR03631 592022000519 30S ribosomal protein S11; Validated; Region: PRK05309 592022000520 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 592022000521 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 592022000522 alphaNTD homodimer interface [polypeptide binding]; other site 592022000523 alphaNTD - beta interaction site [polypeptide binding]; other site 592022000524 alphaNTD - beta' interaction site [polypeptide binding]; other site 592022000525 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 592022000526 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 592022000527 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 592022000528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 592022000529 Walker A/P-loop; other site 592022000530 ATP binding site [chemical binding]; other site 592022000531 Q-loop/lid; other site 592022000532 ABC transporter signature motif; other site 592022000533 Walker B; other site 592022000534 D-loop; other site 592022000535 H-loop/switch region; other site 592022000536 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 592022000537 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 592022000538 Walker A/P-loop; other site 592022000539 ATP binding site [chemical binding]; other site 592022000540 Q-loop/lid; other site 592022000541 ABC transporter signature motif; other site 592022000542 Walker B; other site 592022000543 D-loop; other site 592022000544 H-loop/switch region; other site 592022000545 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 592022000546 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 592022000547 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 592022000548 dimerization interface 3.5A [polypeptide binding]; other site 592022000549 active site 592022000550 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 592022000551 23S rRNA interface [nucleotide binding]; other site 592022000552 L3 interface [polypeptide binding]; other site 592022000553 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 592022000554 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 592022000555 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022000556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022000557 active site 592022000558 metal binding site [ion binding]; metal-binding site 592022000559 antiporter inner membrane protein; Provisional; Region: PRK11670 592022000560 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 592022000561 Walker A motif; other site 592022000562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022000563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022000564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592022000565 dimerization interface [polypeptide binding]; other site 592022000566 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 592022000567 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022000568 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 592022000569 Arginase family; Region: Arginase; cd09989 592022000570 agmatinase; Region: agmatinase; TIGR01230 592022000571 active site 592022000572 Mn binding site [ion binding]; other site 592022000573 oligomer interface [polypeptide binding]; other site 592022000574 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 592022000575 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 592022000576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022000577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022000578 DNA binding residues [nucleotide binding] 592022000579 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 592022000580 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 592022000581 Uncharacterized conserved protein [Function unknown]; Region: COG1624 592022000582 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 592022000583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 592022000584 YbbR-like protein; Region: YbbR; pfam07949 592022000585 YbbR-like protein; Region: YbbR; pfam07949 592022000586 YbbR-like protein; Region: YbbR; pfam07949 592022000587 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 592022000588 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 592022000589 active site 592022000590 substrate binding site [chemical binding]; other site 592022000591 metal binding site [ion binding]; metal-binding site 592022000592 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 592022000593 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 592022000594 glutaminase active site [active] 592022000595 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 592022000596 dimer interface [polypeptide binding]; other site 592022000597 active site 592022000598 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 592022000599 dimer interface [polypeptide binding]; other site 592022000600 active site 592022000601 hypothetical protein; Provisional; Region: PRK12378 592022000602 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022000603 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022000604 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022000605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 592022000606 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 592022000607 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 592022000608 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 592022000609 active site 592022000610 P-loop; other site 592022000611 phosphorylation site [posttranslational modification] 592022000612 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592022000613 active site 592022000614 phosphorylation site [posttranslational modification] 592022000615 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 592022000616 HTH domain; Region: HTH_11; pfam08279 592022000617 PRD domain; Region: PRD; pfam00874 592022000618 PRD domain; Region: PRD; pfam00874 592022000619 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 592022000620 active site 592022000621 P-loop; other site 592022000622 phosphorylation site [posttranslational modification] 592022000623 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 592022000624 active site 592022000625 phosphorylation site [posttranslational modification] 592022000626 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 592022000627 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 592022000628 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 592022000629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022000630 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022000631 active site 592022000632 metal binding site [ion binding]; metal-binding site 592022000633 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592022000634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 592022000635 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 592022000636 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 592022000637 Sulfatase; Region: Sulfatase; pfam00884 592022000638 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 592022000639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022000640 non-specific DNA binding site [nucleotide binding]; other site 592022000641 salt bridge; other site 592022000642 sequence-specific DNA binding site [nucleotide binding]; other site 592022000643 Cupin domain; Region: Cupin_2; pfam07883 592022000644 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592022000645 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 592022000646 Walker A/P-loop; other site 592022000647 ATP binding site [chemical binding]; other site 592022000648 Q-loop/lid; other site 592022000649 ABC transporter signature motif; other site 592022000650 Walker B; other site 592022000651 D-loop; other site 592022000652 H-loop/switch region; other site 592022000653 TOBE domain; Region: TOBE_2; pfam08402 592022000654 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592022000655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022000656 dimer interface [polypeptide binding]; other site 592022000657 conserved gate region; other site 592022000658 putative PBP binding loops; other site 592022000659 ABC-ATPase subunit interface; other site 592022000660 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592022000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022000662 dimer interface [polypeptide binding]; other site 592022000663 conserved gate region; other site 592022000664 putative PBP binding loops; other site 592022000665 ABC-ATPase subunit interface; other site 592022000666 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592022000667 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 592022000668 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 592022000669 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592022000670 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022000671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022000672 active site 592022000673 phosphorylation site [posttranslational modification] 592022000674 intermolecular recognition site; other site 592022000675 dimerization interface [polypeptide binding]; other site 592022000676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022000677 DNA binding site [nucleotide binding] 592022000678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022000679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022000680 dimer interface [polypeptide binding]; other site 592022000681 phosphorylation site [posttranslational modification] 592022000682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022000683 ATP binding site [chemical binding]; other site 592022000684 Mg2+ binding site [ion binding]; other site 592022000685 G-X-G motif; other site 592022000686 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 592022000687 ApbE family; Region: ApbE; pfam02424 592022000688 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 592022000689 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 592022000690 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 592022000691 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 592022000692 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592022000693 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022000694 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592022000695 helicase 45; Provisional; Region: PTZ00424 592022000696 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592022000697 ATP binding site [chemical binding]; other site 592022000698 Mg++ binding site [ion binding]; other site 592022000699 motif III; other site 592022000700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022000701 nucleotide binding region [chemical binding]; other site 592022000702 ATP-binding site [chemical binding]; other site 592022000703 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 592022000704 Rhomboid family; Region: Rhomboid; pfam01694 592022000705 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 592022000706 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 592022000707 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 592022000708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 592022000709 active site 592022000710 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592022000711 dimer interface [polypeptide binding]; other site 592022000712 substrate binding site [chemical binding]; other site 592022000713 catalytic residues [active] 592022000714 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 592022000715 PemK-like protein; Region: PemK; pfam02452 592022000716 Rsbr N terminal; Region: Rsbr_N; pfam08678 592022000717 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022000718 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022000719 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 592022000720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022000721 ATP binding site [chemical binding]; other site 592022000722 Mg2+ binding site [ion binding]; other site 592022000723 G-X-G motif; other site 592022000724 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 592022000725 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 592022000726 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 592022000727 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 592022000728 anti sigma factor interaction site; other site 592022000729 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592022000730 regulatory phosphorylation site [posttranslational modification]; other site 592022000731 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 592022000732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022000733 ATP binding site [chemical binding]; other site 592022000734 Mg2+ binding site [ion binding]; other site 592022000735 G-X-G motif; other site 592022000736 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 592022000737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022000738 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592022000739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022000740 DNA binding residues [nucleotide binding] 592022000741 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 592022000742 active site 592022000743 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 592022000744 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 592022000745 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 592022000746 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 592022000747 RNA binding site [nucleotide binding]; other site 592022000748 SprT homologues; Region: SprT; cl01182 592022000749 hypothetical protein; Provisional; Region: PRK04351 592022000750 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 592022000751 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 592022000752 Glycoprotease family; Region: Peptidase_M22; pfam00814 592022000753 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 592022000754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022000755 Coenzyme A binding pocket [chemical binding]; other site 592022000756 UGMP family protein; Validated; Region: PRK09604 592022000757 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 592022000758 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592022000759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022000760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022000761 ABC transporter; Region: ABC_tran_2; pfam12848 592022000762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022000763 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 592022000764 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 592022000765 CoA binding domain; Region: CoA_binding; pfam02629 592022000766 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 592022000767 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 592022000768 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 592022000769 CAAX protease self-immunity; Region: Abi; pfam02517 592022000770 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 592022000771 oligomerisation interface [polypeptide binding]; other site 592022000772 mobile loop; other site 592022000773 roof hairpin; other site 592022000774 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 592022000775 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 592022000776 ring oligomerisation interface [polypeptide binding]; other site 592022000777 ATP/Mg binding site [chemical binding]; other site 592022000778 stacking interactions; other site 592022000779 hinge regions; other site 592022000780 MoxR-like ATPases [General function prediction only]; Region: COG0714 592022000781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022000782 Walker A motif; other site 592022000783 ATP binding site [chemical binding]; other site 592022000784 Walker B motif; other site 592022000785 arginine finger; other site 592022000786 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 592022000787 Protein of unknown function DUF58; Region: DUF58; pfam01882 592022000788 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 592022000789 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 592022000790 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 592022000791 GMP synthase; Reviewed; Region: guaA; PRK00074 592022000792 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 592022000793 AMP/PPi binding site [chemical binding]; other site 592022000794 candidate oxyanion hole; other site 592022000795 catalytic triad [active] 592022000796 potential glutamine specificity residues [chemical binding]; other site 592022000797 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 592022000798 ATP Binding subdomain [chemical binding]; other site 592022000799 Ligand Binding sites [chemical binding]; other site 592022000800 Dimerization subdomain; other site 592022000801 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592022000802 NETI protein; Region: NETI; pfam14044 592022000803 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 592022000804 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 592022000805 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 592022000806 NAD binding site [chemical binding]; other site 592022000807 ATP-grasp domain; Region: ATP-grasp; pfam02222 592022000808 adenylosuccinate lyase; Provisional; Region: PRK07492 592022000809 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 592022000810 tetramer interface [polypeptide binding]; other site 592022000811 active site 592022000812 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 592022000813 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 592022000814 ATP binding site [chemical binding]; other site 592022000815 active site 592022000816 substrate binding site [chemical binding]; other site 592022000817 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 592022000818 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 592022000819 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 592022000820 putative active site [active] 592022000821 catalytic triad [active] 592022000822 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 592022000823 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 592022000824 dimerization interface [polypeptide binding]; other site 592022000825 ATP binding site [chemical binding]; other site 592022000826 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 592022000827 dimerization interface [polypeptide binding]; other site 592022000828 ATP binding site [chemical binding]; other site 592022000829 amidophosphoribosyltransferase; Provisional; Region: PRK07631 592022000830 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 592022000831 active site 592022000832 tetramer interface [polypeptide binding]; other site 592022000833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022000834 active site 592022000835 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 592022000836 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 592022000837 dimerization interface [polypeptide binding]; other site 592022000838 putative ATP binding site [chemical binding]; other site 592022000839 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 592022000840 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 592022000841 active site 592022000842 substrate binding site [chemical binding]; other site 592022000843 cosubstrate binding site; other site 592022000844 catalytic site [active] 592022000845 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 592022000846 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 592022000847 purine monophosphate binding site [chemical binding]; other site 592022000848 dimer interface [polypeptide binding]; other site 592022000849 putative catalytic residues [active] 592022000850 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 592022000851 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 592022000852 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 592022000853 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 592022000854 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 592022000855 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 592022000856 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 592022000857 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 592022000858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592022000859 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592022000860 active site 592022000861 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 592022000862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 592022000863 glycyl-tRNA synthetase; Provisional; Region: PRK04173 592022000864 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592022000865 motif 1; other site 592022000866 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 592022000867 active site 592022000868 motif 2; other site 592022000869 motif 3; other site 592022000870 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 592022000871 anticodon binding site; other site 592022000872 PcrB family; Region: PcrB; pfam01884 592022000873 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 592022000874 substrate binding site [chemical binding]; other site 592022000875 putative active site [active] 592022000876 dimer interface [polypeptide binding]; other site 592022000877 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 592022000878 Part of AAA domain; Region: AAA_19; pfam13245 592022000879 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 592022000880 Family description; Region: UvrD_C_2; pfam13538 592022000881 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 592022000882 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 592022000883 nucleotide binding pocket [chemical binding]; other site 592022000884 K-X-D-G motif; other site 592022000885 catalytic site [active] 592022000886 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 592022000887 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 592022000888 Dimer interface [polypeptide binding]; other site 592022000889 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 592022000890 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 592022000891 putative dimer interface [polypeptide binding]; other site 592022000892 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 592022000893 putative dimer interface [polypeptide binding]; other site 592022000894 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 592022000895 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 592022000896 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 592022000897 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 592022000898 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 592022000899 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 592022000900 GatB domain; Region: GatB_Yqey; pfam02637 592022000901 putative lipid kinase; Reviewed; Region: PRK13337 592022000902 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 592022000903 TRAM domain; Region: TRAM; pfam01938 592022000904 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 592022000905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022000906 S-adenosylmethionine binding site [chemical binding]; other site 592022000907 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 592022000908 catalytic triad [active] 592022000909 putative active site [active] 592022000910 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 592022000911 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022000912 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022000913 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022000914 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022000915 tetratricopeptide (TPR) repeat family protein, frameshift 592022000916 DNA binding domain, excisionase family; Region: excise; TIGR01764 592022000917 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592022000918 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 592022000919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022000920 dimerization interface [polypeptide binding]; other site 592022000921 PAS fold; Region: PAS; pfam00989 592022000922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022000923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022000924 dimer interface [polypeptide binding]; other site 592022000925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022000926 ATP binding site [chemical binding]; other site 592022000927 Mg2+ binding site [ion binding]; other site 592022000928 G-X-G motif; other site 592022000929 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592022000930 active site 592022000931 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 592022000932 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 592022000933 Nitronate monooxygenase; Region: NMO; pfam03060 592022000934 FMN binding site [chemical binding]; other site 592022000935 substrate binding site [chemical binding]; other site 592022000936 putative catalytic residue [active] 592022000937 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 592022000938 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022000939 DNA binding residues [nucleotide binding] 592022000940 drug binding residues [chemical binding]; other site 592022000941 dimer interface [polypeptide binding]; other site 592022000942 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 592022000943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022000944 putative substrate translocation pore; other site 592022000945 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 592022000946 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592022000947 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592022000948 Walker A/P-loop; other site 592022000949 ATP binding site [chemical binding]; other site 592022000950 Q-loop/lid; other site 592022000951 ABC transporter signature motif; other site 592022000952 Walker B; other site 592022000953 D-loop; other site 592022000954 H-loop/switch region; other site 592022000955 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592022000956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022000957 substrate binding pocket [chemical binding]; other site 592022000958 membrane-bound complex binding site; other site 592022000959 hinge residues; other site 592022000960 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592022000961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022000962 dimer interface [polypeptide binding]; other site 592022000963 conserved gate region; other site 592022000964 putative PBP binding loops; other site 592022000965 ABC-ATPase subunit interface; other site 592022000966 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592022000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022000968 dimer interface [polypeptide binding]; other site 592022000969 conserved gate region; other site 592022000970 putative PBP binding loops; other site 592022000971 ABC-ATPase subunit interface; other site 592022000972 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 592022000973 Protein of unknown function (DUF445); Region: DUF445; pfam04286 592022000974 Predicted membrane protein [Function unknown]; Region: COG3212 592022000975 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022000976 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022000977 Predicted membrane protein [Function unknown]; Region: COG3212 592022000978 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022000979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022000980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022000981 dimerization interface [polypeptide binding]; other site 592022000982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022000983 dimer interface [polypeptide binding]; other site 592022000984 phosphorylation site [posttranslational modification] 592022000985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022000986 ATP binding site [chemical binding]; other site 592022000987 Mg2+ binding site [ion binding]; other site 592022000988 G-X-G motif; other site 592022000989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022000991 active site 592022000992 phosphorylation site [posttranslational modification] 592022000993 intermolecular recognition site; other site 592022000994 dimerization interface [polypeptide binding]; other site 592022000995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022000996 DNA binding site [nucleotide binding] 592022000997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022000998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022000999 dimer interface [polypeptide binding]; other site 592022001000 phosphorylation site [posttranslational modification] 592022001001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022001002 ATP binding site [chemical binding]; other site 592022001003 Mg2+ binding site [ion binding]; other site 592022001004 G-X-G motif; other site 592022001005 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022001006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022001007 active site 592022001008 phosphorylation site [posttranslational modification] 592022001009 intermolecular recognition site; other site 592022001010 dimerization interface [polypeptide binding]; other site 592022001011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022001012 DNA binding site [nucleotide binding] 592022001013 Predicted membrane protein [Function unknown]; Region: COG2311 592022001014 Protein of unknown function (DUF418); Region: DUF418; cl12135 592022001015 Protein of unknown function (DUF418); Region: DUF418; pfam04235 592022001016 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022001017 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022001018 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592022001019 Walker A/P-loop; other site 592022001020 ATP binding site [chemical binding]; other site 592022001021 Q-loop/lid; other site 592022001022 ABC transporter signature motif; other site 592022001023 Walker B; other site 592022001024 D-loop; other site 592022001025 H-loop/switch region; other site 592022001026 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 592022001027 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592022001028 active site 592022001029 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 592022001030 High-affinity nickel-transport protein; Region: NicO; cl00964 592022001031 glutamate carboxypeptidase; Reviewed; Region: PRK06133 592022001032 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 592022001033 metal binding site [ion binding]; metal-binding site 592022001034 dimer interface [polypeptide binding]; other site 592022001035 Predicted membrane protein [Function unknown]; Region: COG2259 592022001036 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 592022001037 intracellular protease, PfpI family; Region: PfpI; TIGR01382 592022001038 proposed catalytic triad [active] 592022001039 conserved cys residue [active] 592022001040 DinB family; Region: DinB; cl17821 592022001041 DinB superfamily; Region: DinB_2; pfam12867 592022001042 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 592022001043 active site flap/lid [active] 592022001044 nucleophilic elbow; other site 592022001045 catalytic triad [active] 592022001046 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 592022001047 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 592022001048 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 592022001049 Predicted membrane protein [Function unknown]; Region: COG4129 592022001050 Occludin homology domain; Region: Occludin_ELL; pfam07303 592022001051 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 592022001052 amidohydrolase; Region: amidohydrolases; TIGR01891 592022001053 metal binding site [ion binding]; metal-binding site 592022001054 Uncharacterized conserved protein [Function unknown]; Region: COG1633 592022001055 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 592022001056 dinuclear metal binding motif [ion binding]; other site 592022001057 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 592022001058 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 592022001059 oligomer interface [polypeptide binding]; other site 592022001060 metal binding site [ion binding]; metal-binding site 592022001061 metal binding site [ion binding]; metal-binding site 592022001062 putative Cl binding site [ion binding]; other site 592022001063 aspartate ring; other site 592022001064 basic sphincter; other site 592022001065 hydrophobic gate; other site 592022001066 periplasmic entrance; other site 592022001067 sensory histidine kinase DcuS; Provisional; Region: PRK11086 592022001068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022001069 putative active site [active] 592022001070 heme pocket [chemical binding]; other site 592022001071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022001072 ATP binding site [chemical binding]; other site 592022001073 Mg2+ binding site [ion binding]; other site 592022001074 G-X-G motif; other site 592022001075 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 592022001076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022001077 active site 592022001078 phosphorylation site [posttranslational modification] 592022001079 intermolecular recognition site; other site 592022001080 dimerization interface [polypeptide binding]; other site 592022001081 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 592022001082 DNA-binding site [nucleotide binding]; DNA binding site 592022001083 B12 binding domain; Region: B12-binding_2; pfam02607 592022001084 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 592022001085 B12 binding site [chemical binding]; other site 592022001086 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022001087 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022001088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022001089 putative active site [active] 592022001090 heme pocket [chemical binding]; other site 592022001091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022001092 dimer interface [polypeptide binding]; other site 592022001093 phosphorylation site [posttranslational modification] 592022001094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022001095 ATP binding site [chemical binding]; other site 592022001096 Mg2+ binding site [ion binding]; other site 592022001097 G-X-G motif; other site 592022001098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 592022001099 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592022001100 ATP binding site [chemical binding]; other site 592022001101 putative Mg++ binding site [ion binding]; other site 592022001102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022001103 nucleotide binding region [chemical binding]; other site 592022001104 ATP-binding site [chemical binding]; other site 592022001105 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 592022001106 SseB protein; Region: SseB; cl06279 592022001107 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 592022001108 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 592022001109 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 592022001110 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 592022001111 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 592022001112 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 592022001113 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 592022001114 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 592022001115 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 592022001116 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022001117 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 592022001118 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592022001119 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 592022001120 Endonuclease I; Region: Endonuclease_1; pfam04231 592022001121 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 592022001122 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 592022001123 starch-binding site 2 [chemical binding]; other site 592022001124 starch-binding site 1 [chemical binding]; other site 592022001125 methionine sulfoxide reductase A; Provisional; Region: PRK14054 592022001126 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 592022001127 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592022001128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022001129 Walker A/P-loop; other site 592022001130 ATP binding site [chemical binding]; other site 592022001131 Q-loop/lid; other site 592022001132 ABC transporter signature motif; other site 592022001133 Walker B; other site 592022001134 D-loop; other site 592022001135 H-loop/switch region; other site 592022001136 ABC transporter; Region: ABC_tran_2; pfam12848 592022001137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022001138 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592022001139 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 592022001140 NAD binding site [chemical binding]; other site 592022001141 ligand binding site [chemical binding]; other site 592022001142 catalytic site [active] 592022001143 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 592022001144 active site 592022001145 dimer interface [polypeptide binding]; other site 592022001146 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 592022001147 Predicted transcriptional regulator [Transcription]; Region: COG1959 592022001148 Transcriptional regulator; Region: Rrf2; cl17282 592022001149 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 592022001150 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 592022001151 heme-binding site [chemical binding]; other site 592022001152 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 592022001153 FAD binding pocket [chemical binding]; other site 592022001154 FAD binding motif [chemical binding]; other site 592022001155 phosphate binding motif [ion binding]; other site 592022001156 beta-alpha-beta structure motif; other site 592022001157 NAD binding pocket [chemical binding]; other site 592022001158 Heme binding pocket [chemical binding]; other site 592022001159 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 592022001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022001161 intracellular protease, PfpI family; Region: PfpI; TIGR01382 592022001162 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 592022001163 proposed catalytic triad [active] 592022001164 conserved cys residue [active] 592022001165 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 592022001166 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 592022001167 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 592022001168 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592022001169 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 592022001170 active site 592022001171 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 592022001172 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 592022001173 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 592022001174 Low molecular weight phosphatase family; Region: LMWPc; cd00115 592022001175 active site 592022001176 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 592022001177 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 592022001178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592022001179 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592022001180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022001181 dimerization interface [polypeptide binding]; other site 592022001182 putative DNA binding site [nucleotide binding]; other site 592022001183 putative Zn2+ binding site [ion binding]; other site 592022001184 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 592022001185 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 592022001186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022001187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022001188 putative substrate translocation pore; other site 592022001189 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 592022001190 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 592022001191 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 592022001192 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 592022001193 calcium/proton exchanger (cax); Region: cax; TIGR00378 592022001194 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592022001195 YfkD-like protein; Region: YfkD; pfam14167 592022001196 Radical SAM superfamily; Region: Radical_SAM; pfam04055 592022001197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022001198 FeS/SAM binding site; other site 592022001199 YfkB-like domain; Region: YfkB; pfam08756 592022001200 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 592022001201 Fumarase C-terminus; Region: Fumerase_C; pfam05683 592022001202 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 592022001203 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 592022001204 NodB motif; other site 592022001205 active site 592022001206 catalytic site [active] 592022001207 Cd binding site [ion binding]; other site 592022001208 TRAM domain; Region: TRAM; pfam01938 592022001209 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 592022001210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022001211 S-adenosylmethionine binding site [chemical binding]; other site 592022001212 putative FAD-dependent oxidoreductase, frameshift 592022001213 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 592022001214 Cache domain; Region: Cache_1; pfam02743 592022001215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 592022001216 HAMP domain; Region: HAMP; pfam00672 592022001217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022001218 putative active site [active] 592022001219 heme pocket [chemical binding]; other site 592022001220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022001221 phosphorylation site [posttranslational modification] 592022001222 dimer interface [polypeptide binding]; other site 592022001223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022001224 ATP binding site [chemical binding]; other site 592022001225 Mg2+ binding site [ion binding]; other site 592022001226 G-X-G motif; other site 592022001227 YfhE-like protein; Region: YfhE; pfam14152 592022001228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022001229 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 592022001230 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 592022001231 active site 592022001232 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 592022001233 TIGR01777 family protein; Region: yfcH 592022001234 putative NAD(P) binding site [chemical binding]; other site 592022001235 putative active site [active] 592022001236 recombination regulator RecX; Provisional; Region: recX; PRK14135 592022001237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022001238 short chain dehydrogenase; Provisional; Region: PRK06924 592022001239 NAD(P) binding site [chemical binding]; other site 592022001240 active site 592022001241 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 592022001242 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 592022001243 WVELL protein; Region: WVELL; pfam14043 592022001244 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 592022001245 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 592022001246 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592022001247 minor groove reading motif; other site 592022001248 helix-hairpin-helix signature motif; other site 592022001249 substrate binding pocket [chemical binding]; other site 592022001250 active site 592022001251 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 592022001252 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 592022001253 DNA binding and oxoG recognition site [nucleotide binding] 592022001254 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 592022001255 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 592022001256 putative NAD(P) binding site [chemical binding]; other site 592022001257 active site 592022001258 YgaB-like protein; Region: YgaB; pfam14182 592022001259 hypothetical protein; Provisional; Region: PRK13662 592022001260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592022001261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022001262 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 592022001263 Walker A/P-loop; other site 592022001264 ATP binding site [chemical binding]; other site 592022001265 Q-loop/lid; other site 592022001266 ABC transporter signature motif; other site 592022001267 Walker B; other site 592022001268 D-loop; other site 592022001269 H-loop/switch region; other site 592022001270 Predicted membrane protein [Function unknown]; Region: COG4129 592022001271 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 592022001272 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 592022001273 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022001274 inhibitor-cofactor binding pocket; inhibition site 592022001275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022001276 catalytic residue [active] 592022001277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022001278 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 592022001279 Walker A/P-loop; other site 592022001280 ATP binding site [chemical binding]; other site 592022001281 Q-loop/lid; other site 592022001282 ABC transporter signature motif; other site 592022001283 Walker B; other site 592022001284 D-loop; other site 592022001285 H-loop/switch region; other site 592022001286 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 592022001287 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 592022001288 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 592022001289 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 592022001290 Ion channel; Region: Ion_trans_2; pfam07885 592022001291 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592022001292 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 592022001293 catalytic triad [active] 592022001294 ferric uptake regulator; Provisional; Region: fur; PRK09462 592022001295 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592022001296 metal binding site 2 [ion binding]; metal-binding site 592022001297 putative DNA binding helix; other site 592022001298 metal binding site 1 [ion binding]; metal-binding site 592022001299 dimer interface [polypeptide binding]; other site 592022001300 structural Zn2+ binding site [ion binding]; other site 592022001301 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 592022001302 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 592022001303 B3/4 domain; Region: B3_4; pfam03483 592022001304 epoxyqueuosine reductase; Region: TIGR00276 592022001305 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 592022001306 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 592022001307 Putative amidase domain; Region: Amidase_6; pfam12671 592022001308 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 592022001309 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 592022001310 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 592022001311 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 592022001312 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022001313 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022001314 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022001315 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 592022001316 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 592022001317 VanZ like family; Region: VanZ; pfam04892 592022001318 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 592022001319 ThiC-associated domain; Region: ThiC-associated; pfam13667 592022001320 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 592022001321 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 592022001322 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022001323 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022001324 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 592022001325 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592022001326 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022001327 EcsC protein family; Region: EcsC; pfam12787 592022001328 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022001329 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 592022001330 Melibiase; Region: Melibiase; pfam02065 592022001331 biotin synthase; Validated; Region: PRK06256 592022001332 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022001333 FeS/SAM binding site; other site 592022001334 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 592022001335 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 592022001336 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592022001337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022001338 Walker A/P-loop; other site 592022001339 ATP binding site [chemical binding]; other site 592022001340 Q-loop/lid; other site 592022001341 ABC transporter signature motif; other site 592022001342 Walker B; other site 592022001343 D-loop; other site 592022001344 H-loop/switch region; other site 592022001345 TOBE domain; Region: TOBE_2; pfam08402 592022001346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022001347 dimer interface [polypeptide binding]; other site 592022001348 conserved gate region; other site 592022001349 putative PBP binding loops; other site 592022001350 ABC-ATPase subunit interface; other site 592022001351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592022001352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022001353 dimer interface [polypeptide binding]; other site 592022001354 conserved gate region; other site 592022001355 putative PBP binding loops; other site 592022001356 ABC-ATPase subunit interface; other site 592022001357 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022001358 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592022001359 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 592022001360 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 592022001361 active site 592022001362 catalytic site [active] 592022001363 metal binding site [ion binding]; metal-binding site 592022001364 dimer interface [polypeptide binding]; other site 592022001365 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 592022001366 Predicted integral membrane protein [Function unknown]; Region: COG5505 592022001367 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592022001368 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 592022001369 active site 592022001370 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022001371 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022001372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022001373 Coenzyme A binding pocket [chemical binding]; other site 592022001374 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 592022001375 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022001376 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 592022001377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022001378 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022001379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 592022001380 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 592022001381 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 592022001382 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022001383 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022001384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022001385 Coenzyme A binding pocket [chemical binding]; other site 592022001386 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 592022001387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022001388 Coenzyme A binding pocket [chemical binding]; other site 592022001389 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 592022001390 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 592022001391 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 592022001392 putative active site [active] 592022001393 catalytic site [active] 592022001394 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 592022001395 putative active site [active] 592022001396 catalytic site [active] 592022001397 Heat induced stress protein YflT; Region: YflT; pfam11181 592022001398 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022001399 Predicted peptidase [General function prediction only]; Region: COG4099 592022001400 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022001401 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022001402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022001403 DNA binding site [nucleotide binding] 592022001404 domain linker motif; other site 592022001405 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592022001406 dimerization interface [polypeptide binding]; other site 592022001407 ligand binding site [chemical binding]; other site 592022001408 polyol permease family; Region: 2A0118; TIGR00897 592022001409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022001410 putative substrate translocation pore; other site 592022001411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022001412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022001413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022001414 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022001415 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592022001416 substrate binding site [chemical binding]; other site 592022001417 ATP binding site [chemical binding]; other site 592022001418 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 592022001419 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 592022001420 tetrameric interface [polypeptide binding]; other site 592022001421 NAD binding site [chemical binding]; other site 592022001422 catalytic residues [active] 592022001423 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 592022001424 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592022001425 PYR/PP interface [polypeptide binding]; other site 592022001426 dimer interface [polypeptide binding]; other site 592022001427 TPP binding site [chemical binding]; other site 592022001428 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022001429 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 592022001430 TPP-binding site; other site 592022001431 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022001432 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022001433 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022001434 DNA binding site [nucleotide binding] 592022001435 domain linker motif; other site 592022001436 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592022001437 dimerization interface [polypeptide binding]; other site 592022001438 ligand binding site [chemical binding]; other site 592022001439 KduI/IolB family; Region: KduI; pfam04962 592022001440 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022001441 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022001442 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022001443 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022001444 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 592022001445 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 592022001446 AsnC family; Region: AsnC_trans_reg; pfam01037 592022001447 QueT transporter; Region: QueT; pfam06177 592022001448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022001449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022001450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022001451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022001452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022001453 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 592022001454 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022001455 RNA binding surface [nucleotide binding]; other site 592022001456 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 592022001457 probable active site [active] 592022001458 TIGR01177 family protein; Region: TIGR01177 592022001459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022001460 S-adenosylmethionine binding site [chemical binding]; other site 592022001461 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 592022001462 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592022001463 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 592022001464 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 592022001465 nucleotide binding site [chemical binding]; other site 592022001466 SulA interaction site; other site 592022001467 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592022001468 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 592022001469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022001470 Coenzyme A binding pocket [chemical binding]; other site 592022001471 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 592022001472 Citrate transporter; Region: CitMHS; pfam03600 592022001473 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 592022001474 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592022001475 active site 592022001476 SET domain; Region: SET; pfam00856 592022001477 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592022001478 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592022001479 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 592022001480 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592022001481 NAD(P) binding site [chemical binding]; other site 592022001482 L-lactate permease; Region: Lactate_perm; cl00701 592022001483 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 592022001484 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 592022001485 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 592022001486 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022001487 NAD binding site [chemical binding]; other site 592022001488 dimer interface [polypeptide binding]; other site 592022001489 substrate binding site [chemical binding]; other site 592022001490 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 592022001491 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 592022001492 Cache domain; Region: Cache_1; pfam02743 592022001493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022001494 dimerization interface [polypeptide binding]; other site 592022001495 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592022001496 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592022001497 dimer interface [polypeptide binding]; other site 592022001498 putative CheW interface [polypeptide binding]; other site 592022001499 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592022001500 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592022001501 active site 592022001502 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 592022001503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 592022001504 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592022001505 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022001506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022001507 Coenzyme A binding pocket [chemical binding]; other site 592022001508 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592022001509 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 592022001510 putative active site [active] 592022001511 catalytic triad [active] 592022001512 putative dimer interface [polypeptide binding]; other site 592022001513 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 592022001514 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 592022001515 amphipathic channel; other site 592022001516 Asn-Pro-Ala signature motifs; other site 592022001517 glycerol kinase; Provisional; Region: glpK; PRK00047 592022001518 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 592022001519 N- and C-terminal domain interface [polypeptide binding]; other site 592022001520 active site 592022001521 MgATP binding site [chemical binding]; other site 592022001522 catalytic site [active] 592022001523 metal binding site [ion binding]; metal-binding site 592022001524 glycerol binding site [chemical binding]; other site 592022001525 homotetramer interface [polypeptide binding]; other site 592022001526 homodimer interface [polypeptide binding]; other site 592022001527 FBP binding site [chemical binding]; other site 592022001528 protein IIAGlc interface [polypeptide binding]; other site 592022001529 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 592022001530 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592022001531 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 592022001532 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 592022001533 active site 592022001534 substrate binding site [chemical binding]; other site 592022001535 metal binding site [ion binding]; metal-binding site 592022001536 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 592022001537 YhdB-like protein; Region: YhdB; pfam14148 592022001538 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 592022001539 SpoVR like protein; Region: SpoVR; pfam04293 592022001540 Predicted transcriptional regulator [Transcription]; Region: COG1959 592022001541 Transcriptional regulator; Region: Rrf2; pfam02082 592022001542 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 592022001543 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 592022001544 putative NADP binding site [chemical binding]; other site 592022001545 putative dimer interface [polypeptide binding]; other site 592022001546 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 592022001547 active site 592022001548 dimerization interface [polypeptide binding]; other site 592022001549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592022001550 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592022001551 Walker A/P-loop; other site 592022001552 ATP binding site [chemical binding]; other site 592022001553 Q-loop/lid; other site 592022001554 ABC transporter signature motif; other site 592022001555 Walker B; other site 592022001556 D-loop; other site 592022001557 H-loop/switch region; other site 592022001558 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592022001559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022001560 dimer interface [polypeptide binding]; other site 592022001561 conserved gate region; other site 592022001562 putative PBP binding loops; other site 592022001563 ABC-ATPase subunit interface; other site 592022001564 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592022001565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022001566 substrate binding pocket [chemical binding]; other site 592022001567 membrane-bound complex binding site; other site 592022001568 hinge residues; other site 592022001569 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 592022001570 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 592022001571 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 592022001572 thiamine phosphate binding site [chemical binding]; other site 592022001573 active site 592022001574 pyrophosphate binding site [ion binding]; other site 592022001575 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 592022001576 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592022001577 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 592022001578 thiS-thiF/thiG interaction site; other site 592022001579 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 592022001580 ThiS interaction site; other site 592022001581 putative active site [active] 592022001582 tetramer interface [polypeptide binding]; other site 592022001583 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 592022001584 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 592022001585 ATP binding site [chemical binding]; other site 592022001586 substrate interface [chemical binding]; other site 592022001587 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 592022001588 dimer interface [polypeptide binding]; other site 592022001589 substrate binding site [chemical binding]; other site 592022001590 ATP binding site [chemical binding]; other site 592022001591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592022001592 catalytic core [active] 592022001593 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 592022001594 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 592022001595 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 592022001596 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592022001597 NAD binding site [chemical binding]; other site 592022001598 substrate binding site [chemical binding]; other site 592022001599 putative active site [active] 592022001600 Domain of unknown function DUF21; Region: DUF21; pfam01595 592022001601 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592022001602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592022001603 Transporter associated domain; Region: CorC_HlyC; smart01091 592022001604 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022001605 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 592022001606 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592022001607 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592022001608 Walker A/P-loop; other site 592022001609 ATP binding site [chemical binding]; other site 592022001610 Q-loop/lid; other site 592022001611 ABC transporter signature motif; other site 592022001612 Walker B; other site 592022001613 D-loop; other site 592022001614 H-loop/switch region; other site 592022001615 TOBE domain; Region: TOBE; pfam03459 592022001616 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022001617 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 592022001618 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 592022001619 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 592022001620 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 592022001621 hypothetical protein; Provisional; Region: PRK13676 592022001622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022001623 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022001624 active site 592022001625 motif I; other site 592022001626 motif II; other site 592022001627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 592022001628 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592022001629 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 592022001630 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 592022001631 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 592022001632 dimer interface [polypeptide binding]; other site 592022001633 acyl-activating enzyme (AAE) consensus motif; other site 592022001634 putative active site [active] 592022001635 AMP binding site [chemical binding]; other site 592022001636 putative CoA binding site [chemical binding]; other site 592022001637 enoyl-CoA hydratase; Provisional; Region: PRK07659 592022001638 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022001639 substrate binding site [chemical binding]; other site 592022001640 oxyanion hole (OAH) forming residues; other site 592022001641 trimer interface [polypeptide binding]; other site 592022001642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 592022001643 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592022001644 IHF dimer interface [polypeptide binding]; other site 592022001645 IHF - DNA interface [nucleotide binding]; other site 592022001646 YhzD-like protein; Region: YhzD; pfam14120 592022001647 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 592022001648 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 592022001649 Walker A/P-loop; other site 592022001650 ATP binding site [chemical binding]; other site 592022001651 Q-loop/lid; other site 592022001652 ABC transporter signature motif; other site 592022001653 Walker B; other site 592022001654 D-loop; other site 592022001655 H-loop/switch region; other site 592022001656 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 592022001657 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 592022001658 ABC-2 type transporter; Region: ABC2_membrane; cl17235 592022001659 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 592022001660 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 592022001661 generic binding surface II; other site 592022001662 generic binding surface I; other site 592022001663 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022001664 Zn2+ binding site [ion binding]; other site 592022001665 Mg2+ binding site [ion binding]; other site 592022001666 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 592022001667 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 592022001668 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592022001669 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 592022001670 transcriptional regulator Hpr; Provisional; Region: PRK13777 592022001671 MarR family; Region: MarR; pfam01047 592022001672 YtxH-like protein; Region: YtxH; cl02079 592022001673 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 592022001674 homodimer interface [polypeptide binding]; other site 592022001675 substrate-cofactor binding pocket; other site 592022001676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022001677 catalytic residue [active] 592022001678 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022001679 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592022001680 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 592022001681 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 592022001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022001683 Coenzyme A binding pocket [chemical binding]; other site 592022001684 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 592022001685 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 592022001686 catalytic triad [active] 592022001687 catalytic triad [active] 592022001688 oxyanion hole [active] 592022001689 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 592022001690 HIT family signature motif; other site 592022001691 catalytic residue [active] 592022001692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592022001693 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 592022001694 Walker A/P-loop; other site 592022001695 ATP binding site [chemical binding]; other site 592022001696 Q-loop/lid; other site 592022001697 ABC transporter signature motif; other site 592022001698 Walker B; other site 592022001699 D-loop; other site 592022001700 H-loop/switch region; other site 592022001701 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 592022001702 EcsC protein family; Region: EcsC; pfam12787 592022001703 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592022001704 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 592022001705 metal binding site [ion binding]; metal-binding site 592022001706 dimer interface [polypeptide binding]; other site 592022001707 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 592022001708 active site 592022001709 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592022001710 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 592022001711 Transglycosylase; Region: Transgly; pfam00912 592022001712 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 592022001713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022001714 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 592022001715 substrate binding site [chemical binding]; other site 592022001716 active site 592022001717 ferrochelatase; Provisional; Region: PRK12435 592022001718 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 592022001719 C-terminal domain interface [polypeptide binding]; other site 592022001720 active site 592022001721 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 592022001722 active site 592022001723 N-terminal domain interface [polypeptide binding]; other site 592022001724 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 592022001725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022001726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022001727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022001728 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022001729 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 592022001730 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022001731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022001732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022001733 PBP superfamily domain; Region: PBP_like_2; cl17296 592022001734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592022001735 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 592022001736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022001737 dimerization interface [polypeptide binding]; other site 592022001738 Histidine kinase; Region: His_kinase; pfam06580 592022001739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022001740 ATP binding site [chemical binding]; other site 592022001741 Mg2+ binding site [ion binding]; other site 592022001742 G-X-G motif; other site 592022001743 Response regulator receiver domain; Region: Response_reg; pfam00072 592022001744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022001745 active site 592022001746 phosphorylation site [posttranslational modification] 592022001747 intermolecular recognition site; other site 592022001748 dimerization interface [polypeptide binding]; other site 592022001749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022001750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022001751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022001752 YhfH-like protein; Region: YhfH; pfam14149 592022001753 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 592022001754 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 592022001755 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 592022001756 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 592022001757 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 592022001758 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 592022001759 acyl-activating enzyme (AAE) consensus motif; other site 592022001760 putative AMP binding site [chemical binding]; other site 592022001761 putative active site [active] 592022001762 putative CoA binding site [chemical binding]; other site 592022001763 enoyl-CoA hydratase; Provisional; Region: PRK07657 592022001764 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022001765 substrate binding site [chemical binding]; other site 592022001766 oxyanion hole (OAH) forming residues; other site 592022001767 trimer interface [polypeptide binding]; other site 592022001768 Peptidase family M48; Region: Peptidase_M48; pfam01435 592022001769 isocitrate lyase; Provisional; Region: PRK15063 592022001770 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 592022001771 tetramer interface [polypeptide binding]; other site 592022001772 active site 592022001773 Mg2+/Mn2+ binding site [ion binding]; other site 592022001774 IDEAL domain; Region: IDEAL; pfam08858 592022001775 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 592022001776 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592022001777 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022001778 Uncharacterized conserved protein [Function unknown]; Region: COG0398 592022001779 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022001780 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022001781 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 592022001782 NAD(P) binding site [chemical binding]; other site 592022001783 homotetramer interface [polypeptide binding]; other site 592022001784 homodimer interface [polypeptide binding]; other site 592022001785 active site 592022001786 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 592022001787 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 592022001788 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 592022001789 Part of AAA domain; Region: AAA_19; pfam13245 592022001790 Family description; Region: UvrD_C_2; pfam13538 592022001791 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 592022001792 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 592022001793 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 592022001794 active site 592022001795 metal binding site [ion binding]; metal-binding site 592022001796 DNA binding site [nucleotide binding] 592022001797 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 592022001798 exonuclease SbcC; Region: sbcc; TIGR00618 592022001799 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 592022001800 Walker A/P-loop; other site 592022001801 ATP binding site [chemical binding]; other site 592022001802 Q-loop/lid; other site 592022001803 ABC transporter signature motif; other site 592022001804 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 592022001805 ABC transporter signature motif; other site 592022001806 Walker B; other site 592022001807 D-loop; other site 592022001808 H-loop/switch region; other site 592022001809 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592022001810 active site 592022001811 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022001812 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 592022001813 Spore germination protein GerPC; Region: GerPC; pfam10737 592022001814 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 592022001815 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022001816 Predicted membrane protein [Function unknown]; Region: COG2311 592022001817 Protein of unknown function (DUF418); Region: DUF418; cl12135 592022001818 Protein of unknown function (DUF418); Region: DUF418; pfam04235 592022001819 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 592022001820 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 592022001821 active site 592022001822 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 592022001823 dimer interface [polypeptide binding]; other site 592022001824 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 592022001825 Ligand Binding Site [chemical binding]; other site 592022001826 Molecular Tunnel; other site 592022001827 phytoene desaturase; Region: crtI_fam; TIGR02734 592022001828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022001829 phytoene desaturase; Region: crtI_fam; TIGR02734 592022001830 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 592022001831 active site lid residues [active] 592022001832 substrate binding pocket [chemical binding]; other site 592022001833 catalytic residues [active] 592022001834 substrate-Mg2+ binding site; other site 592022001835 aspartate-rich region 1; other site 592022001836 aspartate-rich region 2; other site 592022001837 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 592022001838 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 592022001839 active site 592022001840 catalytic site [active] 592022001841 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 592022001842 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022001843 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022001844 DNA binding site [nucleotide binding] 592022001845 domain linker motif; other site 592022001846 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 592022001847 putative dimerization interface [polypeptide binding]; other site 592022001848 putative ligand binding site [chemical binding]; other site 592022001849 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 592022001850 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 592022001851 Glutamate binding site [chemical binding]; other site 592022001852 homodimer interface [polypeptide binding]; other site 592022001853 NAD binding site [chemical binding]; other site 592022001854 catalytic residues [active] 592022001855 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 592022001856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022001857 inhibitor-cofactor binding pocket; inhibition site 592022001858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022001859 catalytic residue [active] 592022001860 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 592022001861 putative metal binding site [ion binding]; other site 592022001862 putative dimer interface [polypeptide binding]; other site 592022001863 S-methylmethionine transporter; Provisional; Region: PRK11387 592022001864 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 592022001865 PAS domain; Region: PAS_9; pfam13426 592022001866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022001867 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592022001868 Walker A motif; other site 592022001869 ATP binding site [chemical binding]; other site 592022001870 Walker B motif; other site 592022001871 arginine finger; other site 592022001872 short chain dehydrogenase; Provisional; Region: PRK06701 592022001873 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 592022001874 NAD binding site [chemical binding]; other site 592022001875 metal binding site [ion binding]; metal-binding site 592022001876 active site 592022001877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 592022001878 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 592022001879 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 592022001880 S1 domain; Region: S1_2; pfam13509 592022001881 EDD domain protein, DegV family; Region: DegV; TIGR00762 592022001882 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 592022001883 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022001884 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022001885 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022001886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022001887 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022001888 active site 592022001889 motif I; other site 592022001890 motif II; other site 592022001891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022001892 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 592022001893 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592022001894 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 592022001895 ligand binding site [chemical binding]; other site 592022001896 flexible hinge region; other site 592022001897 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592022001898 putative switch regulator; other site 592022001899 non-specific DNA interactions [nucleotide binding]; other site 592022001900 DNA binding site [nucleotide binding] 592022001901 sequence specific DNA binding site [nucleotide binding]; other site 592022001902 putative cAMP binding site [chemical binding]; other site 592022001903 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 592022001904 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592022001905 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 592022001906 heterotetramer interface [polypeptide binding]; other site 592022001907 active site pocket [active] 592022001908 cleavage site 592022001909 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 592022001910 nucleotide binding site [chemical binding]; other site 592022001911 N-acetyl-L-glutamate binding site [chemical binding]; other site 592022001912 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 592022001913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022001914 inhibitor-cofactor binding pocket; inhibition site 592022001915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022001916 catalytic residue [active] 592022001917 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 592022001918 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 592022001919 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 592022001920 catalytic site [active] 592022001921 subunit interface [polypeptide binding]; other site 592022001922 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 592022001923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022001924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592022001925 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 592022001926 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022001927 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592022001928 ornithine carbamoyltransferase; Provisional; Region: PRK00779 592022001929 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592022001930 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592022001931 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 592022001932 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592022001933 NAD(P) binding site [chemical binding]; other site 592022001934 putative active site [active] 592022001935 YjzC-like protein; Region: YjzC; pfam14168 592022001936 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 592022001937 Clp amino terminal domain; Region: Clp_N; pfam02861 592022001938 Clp amino terminal domain; Region: Clp_N; pfam02861 592022001939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022001940 Walker A motif; other site 592022001941 ATP binding site [chemical binding]; other site 592022001942 Walker B motif; other site 592022001943 arginine finger; other site 592022001944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022001945 Walker A motif; other site 592022001946 ATP binding site [chemical binding]; other site 592022001947 Walker B motif; other site 592022001948 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 592022001949 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592022001950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022001951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022001952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022001953 galactokinase; Provisional; Region: PRK05322 592022001954 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 592022001955 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592022001956 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 592022001957 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 592022001958 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 592022001959 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 592022001960 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592022001961 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022001962 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 592022001963 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592022001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022001965 NAD(P) binding site [chemical binding]; other site 592022001966 active site 592022001967 ComZ; Region: ComZ; pfam10815 592022001968 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 592022001969 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592022001970 dimer interface [polypeptide binding]; other site 592022001971 active site 592022001972 CoA binding pocket [chemical binding]; other site 592022001973 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 592022001974 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592022001975 dimer interface [polypeptide binding]; other site 592022001976 active site 592022001977 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 592022001978 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592022001979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022001980 Walker A/P-loop; other site 592022001981 ATP binding site [chemical binding]; other site 592022001982 Q-loop/lid; other site 592022001983 ABC transporter signature motif; other site 592022001984 Walker B; other site 592022001985 D-loop; other site 592022001986 H-loop/switch region; other site 592022001987 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592022001988 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 592022001989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022001990 Walker A/P-loop; other site 592022001991 ATP binding site [chemical binding]; other site 592022001992 Q-loop/lid; other site 592022001993 ABC transporter signature motif; other site 592022001994 Walker B; other site 592022001995 D-loop; other site 592022001996 H-loop/switch region; other site 592022001997 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592022001998 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592022001999 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 592022002000 peptide binding site [polypeptide binding]; other site 592022002001 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592022002002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002003 dimer interface [polypeptide binding]; other site 592022002004 conserved gate region; other site 592022002005 ABC-ATPase subunit interface; other site 592022002006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592022002007 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592022002008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002009 dimer interface [polypeptide binding]; other site 592022002010 conserved gate region; other site 592022002011 putative PBP binding loops; other site 592022002012 ABC-ATPase subunit interface; other site 592022002013 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 592022002014 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 592022002015 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 592022002016 active site 592022002017 HIGH motif; other site 592022002018 dimer interface [polypeptide binding]; other site 592022002019 KMSKS motif; other site 592022002020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 592022002021 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 592022002022 peptide binding site [polypeptide binding]; other site 592022002023 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592022002024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002025 dimer interface [polypeptide binding]; other site 592022002026 conserved gate region; other site 592022002027 putative PBP binding loops; other site 592022002028 ABC-ATPase subunit interface; other site 592022002029 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 592022002030 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592022002031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002032 dimer interface [polypeptide binding]; other site 592022002033 conserved gate region; other site 592022002034 putative PBP binding loops; other site 592022002035 ABC-ATPase subunit interface; other site 592022002036 oligopeptide ABC transporter, ATP-binding protein OppD, frameshift 592022002037 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 592022002038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022002039 Walker A/P-loop; other site 592022002040 ATP binding site [chemical binding]; other site 592022002041 Q-loop/lid; other site 592022002042 ABC transporter signature motif; other site 592022002043 Walker B; other site 592022002044 D-loop; other site 592022002045 H-loop/switch region; other site 592022002046 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592022002047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022002048 Coenzyme A binding pocket [chemical binding]; other site 592022002049 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 592022002050 putrescine transporter; Provisional; Region: potE; PRK10655 592022002051 Spore germination protein; Region: Spore_permease; cl17796 592022002052 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 592022002053 ArsC family; Region: ArsC; pfam03960 592022002054 putative catalytic residues [active] 592022002055 thiol/disulfide switch; other site 592022002056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022002057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022002058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592022002059 dimerization interface [polypeptide binding]; other site 592022002060 Malonate transporter MadL subunit; Region: MadL; cl04273 592022002061 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 592022002062 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 592022002063 adaptor protein; Provisional; Region: PRK02315 592022002064 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 592022002065 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 592022002066 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 592022002067 putative active site [active] 592022002068 catalytic site [active] 592022002069 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 592022002070 putative active site [active] 592022002071 catalytic site [active] 592022002072 Competence protein CoiA-like family; Region: CoiA; cl11541 592022002073 oligoendopeptidase F; Region: pepF; TIGR00181 592022002074 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 592022002075 active site 592022002076 Zn binding site [ion binding]; other site 592022002077 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 592022002078 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 592022002079 catalytic residues [active] 592022002080 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 592022002081 apolar tunnel; other site 592022002082 heme binding site [chemical binding]; other site 592022002083 dimerization interface [polypeptide binding]; other site 592022002084 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 592022002085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592022002086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592022002087 catalytic residue [active] 592022002088 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 592022002089 putative active site [active] 592022002090 putative metal binding residues [ion binding]; other site 592022002091 signature motif; other site 592022002092 putative triphosphate binding site [ion binding]; other site 592022002093 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 592022002094 synthetase active site [active] 592022002095 NTP binding site [chemical binding]; other site 592022002096 metal binding site [ion binding]; metal-binding site 592022002097 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 592022002098 ATP-NAD kinase; Region: NAD_kinase; pfam01513 592022002099 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592022002100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022002101 RNA binding surface [nucleotide binding]; other site 592022002102 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592022002103 active site 592022002104 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 592022002105 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 592022002106 active site 592022002107 metal binding site [ion binding]; metal-binding site 592022002108 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 592022002109 MgtE intracellular N domain; Region: MgtE_N; pfam03448 592022002110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 592022002111 Divalent cation transporter; Region: MgtE; pfam01769 592022002112 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 592022002113 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 592022002114 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 592022002115 TrkA-N domain; Region: TrkA_N; pfam02254 592022002116 TrkA-C domain; Region: TrkA_C; pfam02080 592022002117 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 592022002118 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 592022002119 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 592022002120 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 592022002121 Peptidase family M48; Region: Peptidase_M48; cl12018 592022002122 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 592022002123 Part of AAA domain; Region: AAA_19; pfam13245 592022002124 Family description; Region: UvrD_C_2; pfam13538 592022002125 Predicted membrane protein [Function unknown]; Region: COG2323 592022002126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022002127 Coenzyme A binding pocket [chemical binding]; other site 592022002128 hypothetical protein; Provisional; Region: PRK13679 592022002129 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 592022002130 Putative esterase; Region: Esterase; pfam00756 592022002131 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592022002132 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 592022002133 tetramer interfaces [polypeptide binding]; other site 592022002134 binuclear metal-binding site [ion binding]; other site 592022002135 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022002136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022002137 Coenzyme A binding pocket [chemical binding]; other site 592022002138 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022002139 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592022002140 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592022002141 putative active site [active] 592022002142 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 592022002143 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022002144 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 592022002145 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 592022002146 N- and C-terminal domain interface [polypeptide binding]; other site 592022002147 active site 592022002148 catalytic site [active] 592022002149 metal binding site [ion binding]; metal-binding site 592022002150 carbohydrate binding site [chemical binding]; other site 592022002151 ATP binding site [chemical binding]; other site 592022002152 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 592022002153 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 592022002154 Na binding site [ion binding]; other site 592022002155 putative substrate binding site [chemical binding]; other site 592022002156 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022002157 GntP family permease; Region: GntP_permease; pfam02447 592022002158 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 592022002159 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022002160 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 592022002161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022002162 putative DNA binding site [nucleotide binding]; other site 592022002163 putative Zn2+ binding site [ion binding]; other site 592022002164 AsnC family; Region: AsnC_trans_reg; pfam01037 592022002165 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 592022002166 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 592022002167 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592022002168 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 592022002169 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592022002170 ATP binding site [chemical binding]; other site 592022002171 Mg++ binding site [ion binding]; other site 592022002172 motif III; other site 592022002173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022002174 nucleotide binding region [chemical binding]; other site 592022002175 ATP-binding site [chemical binding]; other site 592022002176 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 592022002177 RNA binding site [nucleotide binding]; other site 592022002178 Class I aldolases; Region: Aldolase_Class_I; cd00945 592022002179 catalytic residue [active] 592022002180 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 592022002181 Heat induced stress protein YflT; Region: YflT; pfam11181 592022002182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022002183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022002184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022002185 WHG domain; Region: WHG; pfam13305 592022002186 HTH domain; Region: HTH_11; pfam08279 592022002187 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 592022002188 Mga helix-turn-helix domain; Region: Mga; pfam05043 592022002189 PRD domain; Region: PRD; pfam00874 592022002190 PRD domain; Region: PRD; pfam00874 592022002191 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 592022002192 active site 592022002193 P-loop; other site 592022002194 phosphorylation site [posttranslational modification] 592022002195 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592022002196 active site 592022002197 phosphorylation site [posttranslational modification] 592022002198 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 592022002199 active site 592022002200 P-loop; other site 592022002201 phosphorylation site [posttranslational modification] 592022002202 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 592022002203 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 592022002204 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 592022002205 methionine cluster; other site 592022002206 active site 592022002207 phosphorylation site [posttranslational modification] 592022002208 metal binding site [ion binding]; metal-binding site 592022002209 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 592022002210 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 592022002211 NAD binding site [chemical binding]; other site 592022002212 sugar binding site [chemical binding]; other site 592022002213 divalent metal binding site [ion binding]; other site 592022002214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022002215 dimer interface [polypeptide binding]; other site 592022002216 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 592022002217 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 592022002218 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592022002219 Histidine kinase; Region: His_kinase; pfam06580 592022002220 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 592022002221 ATP binding site [chemical binding]; other site 592022002222 Mg2+ binding site [ion binding]; other site 592022002223 G-X-G motif; other site 592022002224 two-component response regulator; Provisional; Region: PRK14084 592022002225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002226 active site 592022002227 phosphorylation site [posttranslational modification] 592022002228 intermolecular recognition site; other site 592022002229 dimerization interface [polypeptide binding]; other site 592022002230 LytTr DNA-binding domain; Region: LytTR; pfam04397 592022002231 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 592022002232 antiholin-like protein LrgB; Provisional; Region: PRK04288 592022002233 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 592022002234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022002235 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592022002236 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592022002237 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 592022002238 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 592022002239 [4Fe-4S] binding site [ion binding]; other site 592022002240 molybdopterin cofactor binding site; other site 592022002241 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 592022002242 molybdopterin cofactor binding site; other site 592022002243 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 592022002244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022002245 putative substrate translocation pore; other site 592022002246 spermidine synthase; Provisional; Region: PRK00811 592022002247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022002248 S-adenosylmethionine binding site [chemical binding]; other site 592022002249 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 592022002250 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 592022002251 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 592022002252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022002253 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 592022002254 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 592022002255 tetramer interface [polypeptide binding]; other site 592022002256 active site 592022002257 Mg2+/Mn2+ binding site [ion binding]; other site 592022002258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592022002259 active site 592022002260 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 592022002261 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 592022002262 PYR/PP interface [polypeptide binding]; other site 592022002263 dimer interface [polypeptide binding]; other site 592022002264 TPP binding site [chemical binding]; other site 592022002265 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 592022002266 TPP-binding site; other site 592022002267 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 592022002268 active site 592022002269 metal-binding site 592022002270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592022002271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022002272 catalytic residue [active] 592022002273 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 592022002274 nudix motif; other site 592022002275 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 592022002276 acetolactate synthase; Reviewed; Region: PRK08617 592022002277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592022002278 PYR/PP interface [polypeptide binding]; other site 592022002279 dimer interface [polypeptide binding]; other site 592022002280 TPP binding site [chemical binding]; other site 592022002281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022002282 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 592022002283 TPP-binding site [chemical binding]; other site 592022002284 dimer interface [polypeptide binding]; other site 592022002285 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 592022002286 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022002287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022002288 dimerization interface [polypeptide binding]; other site 592022002289 putative DNA binding site [nucleotide binding]; other site 592022002290 putative Zn2+ binding site [ion binding]; other site 592022002291 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592022002292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022002293 putative substrate translocation pore; other site 592022002294 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 592022002295 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592022002296 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592022002297 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 592022002298 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 592022002299 Coenzyme A transferase; Region: CoA_trans; cl17247 592022002300 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 592022002301 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 592022002302 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 592022002303 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 592022002304 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 592022002305 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 592022002306 Response regulator receiver domain; Region: Response_reg; pfam00072 592022002307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002308 active site 592022002309 phosphorylation site [posttranslational modification] 592022002310 intermolecular recognition site; other site 592022002311 dimerization interface [polypeptide binding]; other site 592022002312 YcbB domain; Region: YcbB; pfam08664 592022002313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022002314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022002315 ATP binding site [chemical binding]; other site 592022002316 Mg2+ binding site [ion binding]; other site 592022002317 G-X-G motif; other site 592022002318 glutaminase; Reviewed; Region: PRK12357 592022002319 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 592022002320 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 592022002321 amino acid carrier protein; Region: agcS; TIGR00835 592022002322 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592022002323 Na binding site [ion binding]; other site 592022002324 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 592022002325 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 592022002326 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022002327 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 592022002328 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592022002329 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 592022002330 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 592022002331 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592022002332 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 592022002333 iron-sulfur cluster [ion binding]; other site 592022002334 [2Fe-2S] cluster binding site [ion binding]; other site 592022002335 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592022002336 hydrophobic ligand binding site; other site 592022002337 TIGR00245 family protein; Region: TIGR00245 592022002338 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 592022002339 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 592022002340 Walker A/P-loop; other site 592022002341 ATP binding site [chemical binding]; other site 592022002342 Q-loop/lid; other site 592022002343 ABC transporter signature motif; other site 592022002344 Walker B; other site 592022002345 D-loop; other site 592022002346 H-loop/switch region; other site 592022002347 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 592022002348 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592022002349 homodimer interface [polypeptide binding]; other site 592022002350 substrate-cofactor binding pocket; other site 592022002351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022002352 catalytic residue [active] 592022002353 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592022002354 HlyD family secretion protein; Region: HlyD_3; pfam13437 592022002355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592022002356 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592022002357 Walker A/P-loop; other site 592022002358 ATP binding site [chemical binding]; other site 592022002359 Q-loop/lid; other site 592022002360 ABC transporter signature motif; other site 592022002361 Walker B; other site 592022002362 D-loop; other site 592022002363 H-loop/switch region; other site 592022002364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592022002365 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592022002366 FtsX-like permease family; Region: FtsX; pfam02687 592022002367 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 592022002368 active site 592022002369 catalytic residues [active] 592022002370 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 592022002371 dihydropteroate synthase; Region: DHPS; TIGR01496 592022002372 substrate binding pocket [chemical binding]; other site 592022002373 dimer interface [polypeptide binding]; other site 592022002374 inhibitor binding site; inhibition site 592022002375 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 592022002376 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 592022002377 nucleoside transporter; Region: nupC; TIGR00804 592022002378 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592022002379 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592022002380 S-methylmethionine transporter; Provisional; Region: PRK11387 592022002381 BioY family; Region: BioY; pfam02632 592022002382 AAA domain; Region: AAA_26; pfam13500 592022002383 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 592022002384 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 592022002385 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022002386 inhibitor-cofactor binding pocket; inhibition site 592022002387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022002388 catalytic residue [active] 592022002389 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 592022002390 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 592022002391 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022002392 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 592022002393 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 592022002394 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 592022002395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022002396 putative active site [active] 592022002397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022002398 ATP binding site [chemical binding]; other site 592022002399 Mg2+ binding site [ion binding]; other site 592022002400 G-X-G motif; other site 592022002401 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 592022002402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002403 active site 592022002404 phosphorylation site [posttranslational modification] 592022002405 intermolecular recognition site; other site 592022002406 dimerization interface [polypeptide binding]; other site 592022002407 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 592022002408 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 592022002409 glucose-1-dehydrogenase; Provisional; Region: PRK08936 592022002410 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 592022002411 NAD binding site [chemical binding]; other site 592022002412 homodimer interface [polypeptide binding]; other site 592022002413 active site 592022002414 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 592022002415 ApbE family; Region: ApbE; pfam02424 592022002416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022002417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022002418 non-specific DNA binding site [nucleotide binding]; other site 592022002419 salt bridge; other site 592022002420 sequence-specific DNA binding site [nucleotide binding]; other site 592022002421 YolD-like protein; Region: YolD; pfam08863 592022002422 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 592022002423 Sulfatase; Region: Sulfatase; pfam00884 592022002424 YolD-like protein; Region: YolD; pfam08863 592022002425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022002426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022002427 Coenzyme A binding pocket [chemical binding]; other site 592022002428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 592022002429 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 592022002430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022002431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022002432 homodimer interface [polypeptide binding]; other site 592022002433 catalytic residue [active] 592022002434 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 592022002435 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 592022002436 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592022002437 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 592022002438 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 592022002439 Citrate transporter; Region: CitMHS; pfam03600 592022002440 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 592022002441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022002442 putative active site [active] 592022002443 heme pocket [chemical binding]; other site 592022002444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022002445 ATP binding site [chemical binding]; other site 592022002446 Mg2+ binding site [ion binding]; other site 592022002447 G-X-G motif; other site 592022002448 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 592022002449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002450 active site 592022002451 phosphorylation site [posttranslational modification] 592022002452 intermolecular recognition site; other site 592022002453 dimerization interface [polypeptide binding]; other site 592022002454 Transcriptional regulator; Region: CitT; pfam12431 592022002455 HTH domain; Region: HTH_11; cl17392 592022002456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 592022002457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022002458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022002459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022002460 dimerization interface [polypeptide binding]; other site 592022002461 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 592022002462 Putative ammonia monooxygenase; Region: AmoA; pfam05145 592022002463 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 592022002464 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592022002465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022002466 S-adenosylmethionine binding site [chemical binding]; other site 592022002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002468 dimer interface [polypeptide binding]; other site 592022002469 conserved gate region; other site 592022002470 putative PBP binding loops; other site 592022002471 ABC-ATPase subunit interface; other site 592022002472 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 592022002473 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 592022002474 Walker A/P-loop; other site 592022002475 ATP binding site [chemical binding]; other site 592022002476 Q-loop/lid; other site 592022002477 ABC transporter signature motif; other site 592022002478 Walker B; other site 592022002479 D-loop; other site 592022002480 H-loop/switch region; other site 592022002481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 592022002482 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 592022002483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 592022002484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022002485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022002486 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 592022002487 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022002488 tetramerization interface [polypeptide binding]; other site 592022002489 NAD(P) binding site [chemical binding]; other site 592022002490 catalytic residues [active] 592022002491 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 592022002492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022002493 inhibitor-cofactor binding pocket; inhibition site 592022002494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022002495 catalytic residue [active] 592022002496 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 592022002497 agmatinase; Region: agmatinase; TIGR01230 592022002498 oligomer interface [polypeptide binding]; other site 592022002499 putative active site [active] 592022002500 Mn binding site [ion binding]; other site 592022002501 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022002502 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 592022002503 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592022002504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022002505 motif II; other site 592022002506 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592022002507 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592022002508 active site 592022002509 non-prolyl cis peptide bond; other site 592022002510 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592022002511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592022002512 active site 592022002513 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 592022002514 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592022002515 active site 592022002516 dimer interface [polypeptide binding]; other site 592022002517 non-prolyl cis peptide bond; other site 592022002518 insertion regions; other site 592022002519 V-type ATP synthase subunit H; Validated; Region: PRK08404 592022002520 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592022002521 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 592022002522 Flavin binding site [chemical binding]; other site 592022002523 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 592022002524 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 592022002525 siderophore binding site; other site 592022002526 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592022002527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022002528 ABC-ATPase subunit interface; other site 592022002529 dimer interface [polypeptide binding]; other site 592022002530 putative PBP binding regions; other site 592022002531 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592022002532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022002533 ABC-ATPase subunit interface; other site 592022002534 dimer interface [polypeptide binding]; other site 592022002535 putative PBP binding regions; other site 592022002536 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022002537 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022002538 endonuclease VIII; Provisional; Region: PRK10445 592022002539 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 592022002540 DNA binding site [nucleotide binding] 592022002541 catalytic residue [active] 592022002542 putative catalytic residues [active] 592022002543 H2TH interface [polypeptide binding]; other site 592022002544 intercalation triad [nucleotide binding]; other site 592022002545 substrate specificity determining residue; other site 592022002546 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 592022002547 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 592022002548 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 592022002549 dimer interaction site [polypeptide binding]; other site 592022002550 substrate-binding tunnel; other site 592022002551 active site 592022002552 catalytic site [active] 592022002553 substrate binding site [chemical binding]; other site 592022002554 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 592022002555 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 592022002556 putative active site [active] 592022002557 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022002558 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592022002559 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592022002560 putative active site [active] 592022002561 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 592022002562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022002563 active site turn [active] 592022002564 phosphorylation site [posttranslational modification] 592022002565 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022002566 Uncharacterized conserved protein [Function unknown]; Region: COG3589 592022002567 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 592022002568 acetylornithine deacetylase; Validated; Region: PRK08596 592022002569 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592022002570 metal binding site [ion binding]; metal-binding site 592022002571 Putative transcription activator [Transcription]; Region: TenA; COG0819 592022002572 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592022002573 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592022002574 Walker A/P-loop; other site 592022002575 ATP binding site [chemical binding]; other site 592022002576 Q-loop/lid; other site 592022002577 ABC transporter signature motif; other site 592022002578 Walker B; other site 592022002579 D-loop; other site 592022002580 H-loop/switch region; other site 592022002581 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592022002582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002583 dimer interface [polypeptide binding]; other site 592022002584 conserved gate region; other site 592022002585 putative PBP binding loops; other site 592022002586 ABC-ATPase subunit interface; other site 592022002587 NMT1/THI5 like; Region: NMT1; pfam09084 592022002588 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 592022002589 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 592022002590 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022002591 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 592022002592 tetramer interface [polypeptide binding]; other site 592022002593 active site 592022002594 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 592022002595 active site 592022002596 dimer interface [polypeptide binding]; other site 592022002597 magnesium binding site [ion binding]; other site 592022002598 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022002599 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592022002600 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 592022002601 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 592022002602 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 592022002603 G1 box; other site 592022002604 GTP/Mg2+ binding site [chemical binding]; other site 592022002605 Switch I region; other site 592022002606 G2 box; other site 592022002607 G3 box; other site 592022002608 Switch II region; other site 592022002609 G4 box; other site 592022002610 G5 box; other site 592022002611 Nucleoside recognition; Region: Gate; pfam07670 592022002612 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 592022002613 Nucleoside recognition; Region: Gate; pfam07670 592022002614 FeoA domain; Region: FeoA; pfam04023 592022002615 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022002616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022002617 Coenzyme A binding pocket [chemical binding]; other site 592022002618 Predicted membrane protein [Function unknown]; Region: COG1511 592022002619 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022002620 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 592022002621 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 592022002622 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 592022002623 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 592022002624 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592022002625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022002626 S-adenosylmethionine binding site [chemical binding]; other site 592022002627 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 592022002628 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 592022002629 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 592022002630 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 592022002631 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022002632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022002633 dimerization interface [polypeptide binding]; other site 592022002634 putative DNA binding site [nucleotide binding]; other site 592022002635 putative Zn2+ binding site [ion binding]; other site 592022002636 alcohol dehydrogenase, frameshift 592022002637 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592022002638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022002639 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 592022002640 Walker A/P-loop; other site 592022002641 ATP binding site [chemical binding]; other site 592022002642 Q-loop/lid; other site 592022002643 ABC transporter signature motif; other site 592022002644 Walker B; other site 592022002645 D-loop; other site 592022002646 H-loop/switch region; other site 592022002647 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592022002648 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022002649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022002650 Walker A/P-loop; other site 592022002651 ATP binding site [chemical binding]; other site 592022002652 Q-loop/lid; other site 592022002653 ABC transporter signature motif; other site 592022002654 Walker B; other site 592022002655 D-loop; other site 592022002656 H-loop/switch region; other site 592022002657 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 592022002658 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 592022002659 Na binding site [ion binding]; other site 592022002660 Protein of unknown function, DUF485; Region: DUF485; pfam04341 592022002661 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592022002662 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592022002663 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 592022002664 Bacterial transcriptional regulator; Region: IclR; pfam01614 592022002665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022002666 active site 592022002667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022002668 catalytic tetrad [active] 592022002669 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 592022002670 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 592022002671 putative NAD(P) binding site [chemical binding]; other site 592022002672 active site 592022002673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022002674 MarR family; Region: MarR_2; pfam12802 592022002675 MarR family; Region: MarR_2; cl17246 592022002676 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592022002677 carboxyltransferase (CT) interaction site; other site 592022002678 biotinylation site [posttranslational modification]; other site 592022002679 HlyD family secretion protein; Region: HlyD_3; pfam13437 592022002680 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022002681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022002682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022002683 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022002684 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022002685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022002686 MarR family; Region: MarR; pfam01047 592022002687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022002688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022002689 DNA binding site [nucleotide binding] 592022002690 domain linker motif; other site 592022002691 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592022002692 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022002693 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 592022002694 substrate binding site [chemical binding]; other site 592022002695 dimer interface [polypeptide binding]; other site 592022002696 ATP binding site [chemical binding]; other site 592022002697 D-ribose pyranase; Provisional; Region: PRK11797 592022002698 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592022002699 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592022002700 Walker A/P-loop; other site 592022002701 ATP binding site [chemical binding]; other site 592022002702 Q-loop/lid; other site 592022002703 ABC transporter signature motif; other site 592022002704 Walker B; other site 592022002705 D-loop; other site 592022002706 H-loop/switch region; other site 592022002707 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592022002708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592022002709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592022002710 TM-ABC transporter signature motif; other site 592022002711 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 592022002712 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592022002713 ligand binding site [chemical binding]; other site 592022002714 dimerization interface [polypeptide binding]; other site 592022002715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 592022002716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 592022002717 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 592022002718 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022002719 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592022002720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002721 dimer interface [polypeptide binding]; other site 592022002722 putative PBP binding loops; other site 592022002723 ABC-ATPase subunit interface; other site 592022002724 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592022002725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022002726 dimer interface [polypeptide binding]; other site 592022002727 conserved gate region; other site 592022002728 putative PBP binding loops; other site 592022002729 ABC-ATPase subunit interface; other site 592022002730 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592022002731 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002733 Response regulator receiver domain; Region: Response_reg; pfam00072 592022002734 active site 592022002735 phosphorylation site [posttranslational modification] 592022002736 intermolecular recognition site; other site 592022002737 dimerization interface [polypeptide binding]; other site 592022002738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022002739 metal binding site [ion binding]; metal-binding site 592022002740 active site 592022002741 I-site; other site 592022002742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002743 Response regulator receiver domain; Region: Response_reg; pfam00072 592022002744 active site 592022002745 phosphorylation site [posttranslational modification] 592022002746 intermolecular recognition site; other site 592022002747 dimerization interface [polypeptide binding]; other site 592022002748 HEAT repeats; Region: HEAT_2; pfam13646 592022002749 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 592022002750 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 592022002751 DXD motif; other site 592022002752 Response regulator receiver domain; Region: Response_reg; pfam00072 592022002753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002754 active site 592022002755 phosphorylation site [posttranslational modification] 592022002756 intermolecular recognition site; other site 592022002757 dimerization interface [polypeptide binding]; other site 592022002758 HAMP domain; Region: HAMP; pfam00672 592022002759 dimerization interface [polypeptide binding]; other site 592022002760 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592022002761 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592022002762 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022002763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022002764 dimer interface [polypeptide binding]; other site 592022002765 phosphorylation site [posttranslational modification] 592022002766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022002767 ATP binding site [chemical binding]; other site 592022002768 Mg2+ binding site [ion binding]; other site 592022002769 G-X-G motif; other site 592022002770 Response regulator receiver domain; Region: Response_reg; pfam00072 592022002771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022002772 active site 592022002773 phosphorylation site [posttranslational modification] 592022002774 intermolecular recognition site; other site 592022002775 dimerization interface [polypeptide binding]; other site 592022002776 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 592022002777 PGAP1-like protein; Region: PGAP1; pfam07819 592022002778 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 592022002779 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592022002780 catalytic core [active] 592022002781 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 592022002782 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022002783 inhibitor-cofactor binding pocket; inhibition site 592022002784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022002785 catalytic residue [active] 592022002786 YKOF-related Family; Region: Ykof; pfam07615 592022002787 YKOF-related Family; Region: Ykof; pfam07615 592022002788 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 592022002789 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 592022002790 active site 592022002791 putative substrate binding pocket [chemical binding]; other site 592022002792 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592022002793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022002794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022002795 DNA binding site [nucleotide binding] 592022002796 domain linker motif; other site 592022002797 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 592022002798 putative dimerization interface [polypeptide binding]; other site 592022002799 putative ligand binding site [chemical binding]; other site 592022002800 shikimate kinase; Reviewed; Region: aroK; PRK00131 592022002801 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 592022002802 ADP binding site [chemical binding]; other site 592022002803 magnesium binding site [ion binding]; other site 592022002804 putative shikimate binding site; other site 592022002805 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022002806 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 592022002807 NAD(P) binding site [chemical binding]; other site 592022002808 catalytic residues [active] 592022002809 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 592022002810 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592022002811 PYR/PP interface [polypeptide binding]; other site 592022002812 dimer interface [polypeptide binding]; other site 592022002813 TPP binding site [chemical binding]; other site 592022002814 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022002815 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 592022002816 TPP-binding site [chemical binding]; other site 592022002817 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 592022002818 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 592022002819 active site 592022002820 catalytic residue [active] 592022002821 dimer interface [polypeptide binding]; other site 592022002822 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 592022002823 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 592022002824 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022002825 active site turn [active] 592022002826 phosphorylation site [posttranslational modification] 592022002827 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022002828 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 592022002829 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 592022002830 Ca binding site [ion binding]; other site 592022002831 active site 592022002832 catalytic site [active] 592022002833 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 592022002834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022002835 DNA-binding site [nucleotide binding]; DNA binding site 592022002836 UTRA domain; Region: UTRA; pfam07702 592022002837 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 592022002838 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 592022002839 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 592022002840 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 592022002841 putative active site [active] 592022002842 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 592022002843 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 592022002844 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 592022002845 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 592022002846 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 592022002847 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 592022002848 putative FMN binding site [chemical binding]; other site 592022002849 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592022002850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022002851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022002852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022002853 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 592022002854 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592022002855 putative NAD(P) binding site [chemical binding]; other site 592022002856 substrate binding site [chemical binding]; other site 592022002857 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022002858 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 592022002859 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592022002860 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592022002861 shikimate binding site; other site 592022002862 NAD(P) binding site [chemical binding]; other site 592022002863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022002864 D-galactonate transporter; Region: 2A0114; TIGR00893 592022002865 putative substrate translocation pore; other site 592022002866 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 592022002867 CoA-transferase family III; Region: CoA_transf_3; pfam02515 592022002868 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 592022002869 active site 592022002870 catalytic residues [active] 592022002871 metal binding site [ion binding]; metal-binding site 592022002872 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 592022002873 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022002874 NAD(P) binding site [chemical binding]; other site 592022002875 catalytic residues [active] 592022002876 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022002877 allophanate hydrolase; Provisional; Region: PRK08186 592022002878 Amidase; Region: Amidase; cl11426 592022002879 urea carboxylase; Region: urea_carbox; TIGR02712 592022002880 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022002881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592022002882 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 592022002883 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 592022002884 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 592022002885 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592022002886 carboxyltransferase (CT) interaction site; other site 592022002887 biotinylation site [posttranslational modification]; other site 592022002888 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 592022002889 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 592022002890 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 592022002891 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 592022002892 amino acid transporter; Region: 2A0306; TIGR00909 592022002893 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 592022002894 cytosine deaminase; Provisional; Region: PRK05985 592022002895 active site 592022002896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022002897 DNA-binding site [nucleotide binding]; DNA binding site 592022002898 RNA-binding motif; other site 592022002899 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 592022002900 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592022002901 NAD binding site [chemical binding]; other site 592022002902 substrate binding site [chemical binding]; other site 592022002903 putative active site [active] 592022002904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022002905 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022002906 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592022002907 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 592022002908 dimer interface [polypeptide binding]; other site 592022002909 decamer (pentamer of dimers) interface [polypeptide binding]; other site 592022002910 catalytic triad [active] 592022002911 peroxidatic and resolving cysteines [active] 592022002912 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592022002913 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592022002914 catalytic residues [active] 592022002915 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592022002916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022002917 DNA binding residues [nucleotide binding] 592022002918 YvrJ protein family; Region: YvrJ; pfam12841 592022002919 hypothetical protein; Provisional; Region: PRK14082 592022002920 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 592022002921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592022002922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022002923 metal binding site [ion binding]; metal-binding site 592022002924 active site 592022002925 I-site; other site 592022002926 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 592022002927 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 592022002928 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 592022002929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022002930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022002931 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 592022002932 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022002933 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 592022002934 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 592022002935 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 592022002936 putative active site [active] 592022002937 putative metal binding site [ion binding]; other site 592022002938 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 592022002939 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592022002940 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 592022002941 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592022002942 Staygreen protein; Region: Staygreen; pfam12638 592022002943 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 592022002944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022002945 active site 592022002946 motif I; other site 592022002947 motif II; other site 592022002948 CsbD-like; Region: CsbD; pfam05532 592022002949 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 592022002950 nudix motif; other site 592022002951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 592022002952 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 592022002953 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022002954 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592022002955 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592022002956 putative active site [active] 592022002957 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 592022002958 active site 592022002959 P-loop; other site 592022002960 phosphorylation site [posttranslational modification] 592022002961 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 592022002962 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 592022002963 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 592022002964 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 592022002965 NAD binding site [chemical binding]; other site 592022002966 sugar binding site [chemical binding]; other site 592022002967 divalent metal binding site [ion binding]; other site 592022002968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022002969 dimer interface [polypeptide binding]; other site 592022002970 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 592022002971 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 592022002972 methionine cluster; other site 592022002973 active site 592022002974 phosphorylation site [posttranslational modification] 592022002975 metal binding site [ion binding]; metal-binding site 592022002976 Uncharacterized conserved protein [Function unknown]; Region: COG3589 592022002977 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 592022002978 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 592022002979 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 592022002980 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 592022002981 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 592022002982 putative active site [active] 592022002983 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 592022002984 HTH domain; Region: HTH_11; pfam08279 592022002985 PRD domain; Region: PRD; pfam00874 592022002986 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 592022002987 active site 592022002988 P-loop; other site 592022002989 phosphorylation site [posttranslational modification] 592022002990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592022002991 active site 592022002992 phosphorylation site [posttranslational modification] 592022002993 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 592022002994 active site 592022002995 P-loop; other site 592022002996 phosphorylation site [posttranslational modification] 592022002997 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 592022002998 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592022002999 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 592022003000 active site 592022003001 catalytic triad [active] 592022003002 dimer interface [polypeptide binding]; other site 592022003003 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 592022003004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022003005 active site 592022003006 dimer interface [polypeptide binding]; other site 592022003007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 592022003008 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592022003009 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 592022003010 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022003011 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022003012 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592022003013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022003014 S-adenosylmethionine binding site [chemical binding]; other site 592022003015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022003016 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 592022003017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022003018 dimerization interface [polypeptide binding]; other site 592022003019 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 592022003020 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022003021 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022003022 active site 592022003023 catalytic tetrad [active] 592022003024 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 592022003025 Amidase; Region: Amidase; cl11426 592022003026 indole-3-acetamide amidohydrolase; Region: PLN02722 592022003027 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592022003028 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592022003029 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 592022003030 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 592022003031 NAD binding site [chemical binding]; other site 592022003032 homodimer interface [polypeptide binding]; other site 592022003033 active site 592022003034 substrate binding site [chemical binding]; other site 592022003035 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 592022003036 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022003037 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592022003038 PAS fold; Region: PAS_4; pfam08448 592022003039 PAS domain S-box; Region: sensory_box; TIGR00229 592022003040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003041 putative active site [active] 592022003042 heme pocket [chemical binding]; other site 592022003043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003044 PAS domain; Region: PAS_9; pfam13426 592022003045 putative active site [active] 592022003046 heme pocket [chemical binding]; other site 592022003047 PAS domain; Region: PAS_9; pfam13426 592022003048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003049 putative active site [active] 592022003050 heme pocket [chemical binding]; other site 592022003051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592022003052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022003053 metal binding site [ion binding]; metal-binding site 592022003054 active site 592022003055 I-site; other site 592022003056 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022003057 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592022003058 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 592022003059 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 592022003060 glucose-1-dehydrogenase; Provisional; Region: PRK08936 592022003061 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 592022003062 NAD binding site [chemical binding]; other site 592022003063 homodimer interface [polypeptide binding]; other site 592022003064 active site 592022003065 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 592022003066 Sodium Bile acid symporter family; Region: SBF; pfam01758 592022003067 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 592022003068 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592022003069 Na binding site [ion binding]; other site 592022003070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592022003071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022003072 ATP binding site [chemical binding]; other site 592022003073 Mg2+ binding site [ion binding]; other site 592022003074 G-X-G motif; other site 592022003075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022003076 Response regulator receiver domain; Region: Response_reg; pfam00072 592022003077 active site 592022003078 phosphorylation site [posttranslational modification] 592022003079 intermolecular recognition site; other site 592022003080 dimerization interface [polypeptide binding]; other site 592022003081 YcbB domain; Region: YcbB; pfam08664 592022003082 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022003083 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022003084 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022003085 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022003086 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022003087 active site 592022003088 metal binding site [ion binding]; metal-binding site 592022003089 Stage II sporulation protein; Region: SpoIID; pfam08486 592022003090 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 592022003091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022003092 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022003093 active site 592022003094 catalytic tetrad [active] 592022003095 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 592022003096 IDEAL domain; Region: IDEAL; cl07452 592022003097 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 592022003098 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 592022003099 transmembrane helices; other site 592022003100 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 592022003101 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 592022003102 active site 592022003103 octamer interface [polypeptide binding]; other site 592022003104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022003105 Coenzyme A binding pocket [chemical binding]; other site 592022003106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022003107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592022003108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592022003109 putative active site [active] 592022003110 PAS domain; Region: PAS_9; pfam13426 592022003111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 592022003112 putative active site [active] 592022003113 heme pocket [chemical binding]; other site 592022003114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022003115 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592022003116 Walker A motif; other site 592022003117 ATP binding site [chemical binding]; other site 592022003118 Walker B motif; other site 592022003119 arginine finger; other site 592022003120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 592022003121 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 592022003122 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022003123 inhibitor-cofactor binding pocket; inhibition site 592022003124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022003125 catalytic residue [active] 592022003126 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 592022003127 Na binding site [ion binding]; other site 592022003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022003129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022003130 putative substrate translocation pore; other site 592022003131 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592022003132 Protein export membrane protein; Region: SecD_SecF; cl14618 592022003133 Protein export membrane protein; Region: SecD_SecF; cl14618 592022003134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022003135 dimerization interface [polypeptide binding]; other site 592022003136 putative DNA binding site [nucleotide binding]; other site 592022003137 putative Zn2+ binding site [ion binding]; other site 592022003138 Predicted integral membrane protein [Function unknown]; Region: COG5658 592022003139 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 592022003140 SdpI/YhfL protein family; Region: SdpI; pfam13630 592022003141 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022003142 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022003143 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022003144 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 592022003145 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 592022003146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022003147 dimerization interface [polypeptide binding]; other site 592022003148 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592022003149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022003150 metal binding site [ion binding]; metal-binding site 592022003151 active site 592022003152 I-site; other site 592022003153 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592022003154 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 592022003155 GTP cyclohydrolase I; Provisional; Region: PLN03044 592022003156 active site 592022003157 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592022003158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022003159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022003160 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 592022003161 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022003162 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 592022003163 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 592022003164 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 592022003165 putative active site [active] 592022003166 putative metal binding site [ion binding]; other site 592022003167 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 592022003168 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592022003169 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022003170 flagellin; Provisional; Region: PRK12804 592022003171 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592022003172 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 592022003173 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 592022003174 putative substrate binding pocket [chemical binding]; other site 592022003175 AC domain interface; other site 592022003176 catalytic triad [active] 592022003177 AB domain interface; other site 592022003178 interchain disulfide; other site 592022003179 Predicted membrane protein [Function unknown]; Region: COG3817 592022003180 Protein of unknown function (DUF979); Region: DUF979; pfam06166 592022003181 Protein of unknown function (DUF969); Region: DUF969; pfam06149 592022003182 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 592022003183 Predicted membrane protein [Function unknown]; Region: COG4640 592022003184 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 592022003185 HPP family; Region: HPP; pfam04982 592022003186 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 592022003187 histidinol-phosphatase; Provisional; Region: PRK05588 592022003188 active site 592022003189 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 592022003190 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 592022003191 active site 592022003192 substrate binding site [chemical binding]; other site 592022003193 metal binding site [ion binding]; metal-binding site 592022003194 Predicted integral membrane protein [Function unknown]; Region: COG5652 592022003195 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022003196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022003197 non-specific DNA binding site [nucleotide binding]; other site 592022003198 salt bridge; other site 592022003199 sequence-specific DNA binding site [nucleotide binding]; other site 592022003200 Anti-repressor SinI; Region: SinI; pfam08671 592022003201 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 592022003202 active site 592022003203 dimer interface [polypeptide binding]; other site 592022003204 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 592022003205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022003206 ABC transporter signature motif; other site 592022003207 Walker B; other site 592022003208 D-loop; other site 592022003209 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 592022003210 trimer interface [polypeptide binding]; other site 592022003211 active site 592022003212 substrate binding site [chemical binding]; other site 592022003213 CoA binding site [chemical binding]; other site 592022003214 HTH-like domain; Region: HTH_21; pfam13276 592022003215 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 592022003216 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592022003217 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 592022003218 active site 592022003219 tetramer interface; other site 592022003220 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592022003221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022003222 active site 592022003223 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 592022003224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022003225 active site 592022003226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592022003227 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592022003228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592022003229 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 592022003230 putative ADP-binding pocket [chemical binding]; other site 592022003231 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 592022003232 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 592022003233 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 592022003234 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592022003235 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 592022003236 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 592022003237 Chain length determinant protein; Region: Wzz; cl15801 592022003238 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 592022003239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592022003240 Magnesium ion binding site [ion binding]; other site 592022003241 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 592022003242 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592022003243 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 592022003244 active site 592022003245 tetramer interface; other site 592022003246 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 592022003247 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 592022003248 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 592022003249 pyruvate oxidase; Provisional; Region: PRK08611 592022003250 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 592022003251 PYR/PP interface [polypeptide binding]; other site 592022003252 dimer interface [polypeptide binding]; other site 592022003253 tetramer interface [polypeptide binding]; other site 592022003254 TPP binding site [chemical binding]; other site 592022003255 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022003256 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 592022003257 TPP-binding site [chemical binding]; other site 592022003258 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 592022003259 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 592022003260 active site 592022003261 FMN binding site [chemical binding]; other site 592022003262 substrate binding site [chemical binding]; other site 592022003263 3Fe-4S cluster binding site [ion binding]; other site 592022003264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022003265 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 592022003266 DNA-binding site [nucleotide binding]; DNA binding site 592022003267 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592022003268 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 592022003269 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022003270 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 592022003271 GntP family permease; Region: GntP_permease; pfam02447 592022003272 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022003273 ComK protein; Region: ComK; cl11560 592022003274 RNA polymerase factor sigma-70; Validated; Region: PRK06759 592022003275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022003276 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 592022003277 DNA binding residues [nucleotide binding] 592022003278 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 592022003279 active site 592022003280 oxyanion hole [active] 592022003281 catalytic triad [active] 592022003282 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 592022003283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022003284 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592022003285 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592022003286 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592022003287 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 592022003288 [2Fe-2S] cluster binding site [ion binding]; other site 592022003289 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 592022003290 active site 592022003291 SAM binding site [chemical binding]; other site 592022003292 homodimer interface [polypeptide binding]; other site 592022003293 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 592022003294 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022003295 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 592022003296 putative substrate binding site [chemical binding]; other site 592022003297 putative ATP binding site [chemical binding]; other site 592022003298 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 592022003299 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592022003300 active site 592022003301 metal binding site [ion binding]; metal-binding site 592022003302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022003303 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 592022003304 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 592022003305 GIY-YIG motif/motif A; other site 592022003306 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 592022003307 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 592022003308 Cupin; Region: Cupin_1; smart00835 592022003309 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 592022003310 PilZ domain; Region: PilZ; pfam07238 592022003311 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 592022003312 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 592022003313 oligomer interface [polypeptide binding]; other site 592022003314 metal binding site [ion binding]; metal-binding site 592022003315 metal binding site [ion binding]; metal-binding site 592022003316 putative Cl binding site [ion binding]; other site 592022003317 aspartate ring; other site 592022003318 basic sphincter; other site 592022003319 hydrophobic gate; other site 592022003320 periplasmic entrance; other site 592022003321 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 592022003322 active site 592022003323 catalytic triad [active] 592022003324 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 592022003325 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022003326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022003327 Coenzyme A binding pocket [chemical binding]; other site 592022003328 hypothetical protein; Provisional; Region: PRK02947 592022003329 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592022003330 putative active site [active] 592022003331 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 592022003332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022003333 DNA-binding site [nucleotide binding]; DNA binding site 592022003334 UTRA domain; Region: UTRA; pfam07702 592022003335 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 592022003336 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 592022003337 active site 592022003338 trimer interface [polypeptide binding]; other site 592022003339 allosteric site; other site 592022003340 active site lid [active] 592022003341 hexamer (dimer of trimers) interface [polypeptide binding]; other site 592022003342 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 592022003343 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 592022003344 active site 592022003345 dimer interface [polypeptide binding]; other site 592022003346 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 592022003347 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022003348 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022003349 active site turn [active] 592022003350 phosphorylation site [posttranslational modification] 592022003351 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 592022003352 HPr interaction site; other site 592022003353 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592022003354 active site 592022003355 phosphorylation site [posttranslational modification] 592022003356 Protein of unknown function (DUF554); Region: DUF554; pfam04474 592022003357 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022003358 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022003359 active site 592022003360 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022003361 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022003362 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 592022003363 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 592022003364 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 592022003365 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592022003366 Walker A/P-loop; other site 592022003367 ATP binding site [chemical binding]; other site 592022003368 Q-loop/lid; other site 592022003369 ABC transporter signature motif; other site 592022003370 Walker B; other site 592022003371 D-loop; other site 592022003372 H-loop/switch region; other site 592022003373 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592022003374 Domain of unknown function DUF21; Region: DUF21; pfam01595 592022003375 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592022003376 Transporter associated domain; Region: CorC_HlyC; smart01091 592022003377 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592022003378 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022003379 DNA binding residues [nucleotide binding] 592022003380 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 592022003381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022003382 putative metal binding site [ion binding]; other site 592022003383 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 592022003384 putative active site pocket [active] 592022003385 dimerization interface [polypeptide binding]; other site 592022003386 putative catalytic residue [active] 592022003387 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 592022003388 putative active site pocket [active] 592022003389 dimerization interface [polypeptide binding]; other site 592022003390 putative catalytic residue [active] 592022003391 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 592022003392 active site 592022003393 catalytic residues [active] 592022003394 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 592022003395 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 592022003396 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 592022003397 Catalytic site [active] 592022003398 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592022003399 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 592022003400 YmaF family; Region: YmaF; pfam12788 592022003401 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 592022003402 Protein of unknown function DUF45; Region: DUF45; cl00636 592022003403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022003404 Coenzyme A binding pocket [chemical binding]; other site 592022003405 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592022003406 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 592022003407 metal binding site [ion binding]; metal-binding site 592022003408 dimer interface [polypeptide binding]; other site 592022003409 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 592022003410 putative metal binding site [ion binding]; other site 592022003411 putative dimer interface [polypeptide binding]; other site 592022003412 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 592022003413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022003414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022003415 Coenzyme A binding pocket [chemical binding]; other site 592022003416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022003417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022003418 putative substrate translocation pore; other site 592022003419 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592022003420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022003421 ATP binding site [chemical binding]; other site 592022003422 Mg2+ binding site [ion binding]; other site 592022003423 G-X-G motif; other site 592022003424 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592022003425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022003426 active site 592022003427 phosphorylation site [posttranslational modification] 592022003428 intermolecular recognition site; other site 592022003429 dimerization interface [polypeptide binding]; other site 592022003430 LytTr DNA-binding domain; Region: LytTR; smart00850 592022003431 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 592022003432 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 592022003433 Walker A/P-loop; other site 592022003434 ATP binding site [chemical binding]; other site 592022003435 Q-loop/lid; other site 592022003436 ABC transporter signature motif; other site 592022003437 Walker B; other site 592022003438 D-loop; other site 592022003439 H-loop/switch region; other site 592022003440 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 592022003441 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022003442 Phosphotransferase enzyme family; Region: APH; pfam01636 592022003443 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 592022003444 active site 592022003445 substrate binding site [chemical binding]; other site 592022003446 ATP binding site [chemical binding]; other site 592022003447 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 592022003448 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 592022003449 DNA binding residues [nucleotide binding] 592022003450 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022003451 MarR family; Region: MarR; pfam01047 592022003452 methionine sulfoxide reductase A; Provisional; Region: PRK14054 592022003453 methionine sulfoxide reductase B; Provisional; Region: PRK00222 592022003454 SelR domain; Region: SelR; pfam01641 592022003455 Spore germination protein; Region: Spore_permease; cl17796 592022003456 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 592022003457 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 592022003458 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 592022003459 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 592022003460 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 592022003461 dimer interface [polypeptide binding]; other site 592022003462 active site 592022003463 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 592022003464 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592022003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022003466 active site 592022003467 phosphorylation site [posttranslational modification] 592022003468 intermolecular recognition site; other site 592022003469 dimerization interface [polypeptide binding]; other site 592022003470 LytTr DNA-binding domain; Region: LytTR; smart00850 592022003471 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 592022003472 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 592022003473 PAS domain S-box; Region: sensory_box; TIGR00229 592022003474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003475 putative active site [active] 592022003476 heme pocket [chemical binding]; other site 592022003477 PAS domain; Region: PAS_9; pfam13426 592022003478 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022003479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003480 putative active site [active] 592022003481 heme pocket [chemical binding]; other site 592022003482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022003483 dimer interface [polypeptide binding]; other site 592022003484 phosphorylation site [posttranslational modification] 592022003485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022003486 ATP binding site [chemical binding]; other site 592022003487 Mg2+ binding site [ion binding]; other site 592022003488 G-X-G motif; other site 592022003489 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592022003490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022003491 active site 592022003492 phosphorylation site [posttranslational modification] 592022003493 intermolecular recognition site; other site 592022003494 dimerization interface [polypeptide binding]; other site 592022003495 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 592022003496 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 592022003497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022003498 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022003499 polyhydroxyalkanoic acid inclusion protein PhaP; Region: phaP_Bmeg; TIGR02131 592022003500 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 592022003501 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022003502 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 592022003503 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 592022003504 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 592022003505 NAD(P) binding site [chemical binding]; other site 592022003506 homotetramer interface [polypeptide binding]; other site 592022003507 homodimer interface [polypeptide binding]; other site 592022003508 active site 592022003509 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 592022003510 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 592022003511 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 592022003512 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 592022003513 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 592022003514 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 592022003515 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 592022003516 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 592022003517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022003518 FeS/SAM binding site; other site 592022003519 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 592022003520 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592022003521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022003522 DNA-binding site [nucleotide binding]; DNA binding site 592022003523 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592022003524 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 592022003525 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 592022003526 active site 592022003527 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 592022003528 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 592022003529 homodimer interface [polypeptide binding]; other site 592022003530 NAD binding pocket [chemical binding]; other site 592022003531 ATP binding pocket [chemical binding]; other site 592022003532 Mg binding site [ion binding]; other site 592022003533 active-site loop [active] 592022003534 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592022003535 Cysteine-rich domain; Region: CCG; pfam02754 592022003536 Cysteine-rich domain; Region: CCG; pfam02754 592022003537 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 592022003538 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 592022003539 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 592022003540 Uncharacterized conserved protein [Function unknown]; Region: COG1556 592022003541 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 592022003542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003543 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 592022003544 putative active site [active] 592022003545 heme pocket [chemical binding]; other site 592022003546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003547 putative active site [active] 592022003548 heme pocket [chemical binding]; other site 592022003549 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022003550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003551 putative active site [active] 592022003552 heme pocket [chemical binding]; other site 592022003553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022003554 dimer interface [polypeptide binding]; other site 592022003555 phosphorylation site [posttranslational modification] 592022003556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022003557 ATP binding site [chemical binding]; other site 592022003558 Mg2+ binding site [ion binding]; other site 592022003559 G-X-G motif; other site 592022003560 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 592022003561 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592022003562 DNA binding site [nucleotide binding] 592022003563 active site 592022003564 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 592022003565 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 592022003566 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 592022003567 Phosphotransferase enzyme family; Region: APH; pfam01636 592022003568 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592022003569 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 592022003570 putative active site [active] 592022003571 catalytic triad [active] 592022003572 putative dimer interface [polypeptide binding]; other site 592022003573 transaminase; Reviewed; Region: PRK08068 592022003574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022003575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022003576 homodimer interface [polypeptide binding]; other site 592022003577 catalytic residue [active] 592022003578 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 592022003579 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 592022003580 dimer interface [polypeptide binding]; other site 592022003581 active site 592022003582 catalytic residue [active] 592022003583 metal binding site [ion binding]; metal-binding site 592022003584 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 592022003585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022003586 active site 592022003587 motif I; other site 592022003588 motif II; other site 592022003589 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 592022003590 intersubunit interface [polypeptide binding]; other site 592022003591 active site 592022003592 Zn2+ binding site [ion binding]; other site 592022003593 ARD/ARD' family; Region: ARD; pfam03079 592022003594 Cupin domain; Region: Cupin_2; pfam07883 592022003595 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 592022003596 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592022003597 putative ligand binding site [chemical binding]; other site 592022003598 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592022003599 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592022003600 Walker A/P-loop; other site 592022003601 ATP binding site [chemical binding]; other site 592022003602 Q-loop/lid; other site 592022003603 ABC transporter signature motif; other site 592022003604 Walker B; other site 592022003605 D-loop; other site 592022003606 H-loop/switch region; other site 592022003607 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592022003608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592022003609 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592022003610 TM-ABC transporter signature motif; other site 592022003611 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 592022003612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022003613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022003614 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592022003615 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 592022003616 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 592022003617 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 592022003618 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 592022003619 nucleotide binding site/active site [active] 592022003620 HIT family signature motif; other site 592022003621 catalytic residue [active] 592022003622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022003623 MarR family; Region: MarR; pfam01047 592022003624 MarR family; Region: MarR_2; cl17246 592022003625 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 592022003626 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 592022003627 active site 592022003628 Zn binding site [ion binding]; other site 592022003629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022003630 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 592022003631 putative active site [active] 592022003632 heme pocket [chemical binding]; other site 592022003633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022003634 dimer interface [polypeptide binding]; other site 592022003635 phosphorylation site [posttranslational modification] 592022003636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022003637 ATP binding site [chemical binding]; other site 592022003638 Mg2+ binding site [ion binding]; other site 592022003639 G-X-G motif; other site 592022003640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022003641 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592022003642 Walker A motif; other site 592022003643 ATP binding site [chemical binding]; other site 592022003644 Walker B motif; other site 592022003645 arginine finger; other site 592022003646 UvrB/uvrC motif; Region: UVR; pfam02151 592022003647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022003648 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592022003649 Walker A motif; other site 592022003650 ATP binding site [chemical binding]; other site 592022003651 Walker B motif; other site 592022003652 arginine finger; other site 592022003653 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 592022003654 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 592022003655 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 592022003656 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022003657 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 592022003658 classical (c) SDRs; Region: SDR_c; cd05233 592022003659 NAD(P) binding site [chemical binding]; other site 592022003660 active site 592022003661 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 592022003662 Ligand Binding Site [chemical binding]; other site 592022003663 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 592022003664 active site 592022003665 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 592022003666 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 592022003667 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 592022003668 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 592022003669 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 592022003670 NAD binding site [chemical binding]; other site 592022003671 active site 592022003672 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 592022003673 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 592022003674 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 592022003675 active site 592022003676 nucleophile elbow; other site 592022003677 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022003678 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022003679 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 592022003680 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592022003681 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 592022003682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022003683 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022003684 active site 592022003685 motif I; other site 592022003686 motif II; other site 592022003687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022003688 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 592022003689 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 592022003690 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 592022003691 substrate binding pocket [chemical binding]; other site 592022003692 dimer interface [polypeptide binding]; other site 592022003693 inhibitor binding site; inhibition site 592022003694 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 592022003695 B12 binding site [chemical binding]; other site 592022003696 cobalt ligand [ion binding]; other site 592022003697 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 592022003698 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 592022003699 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 592022003700 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 592022003701 FAD binding site [chemical binding]; other site 592022003702 Uncharacterized membrane protein [Function unknown]; Region: COG3949 592022003703 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 592022003704 Lumazine binding domain; Region: Lum_binding; pfam00677 592022003705 Lumazine binding domain; Region: Lum_binding; pfam00677 592022003706 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 592022003707 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 592022003708 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 592022003709 dimerization interface [polypeptide binding]; other site 592022003710 active site 592022003711 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 592022003712 homopentamer interface [polypeptide binding]; other site 592022003713 active site 592022003714 transcriptional antiterminator BglG; Provisional; Region: PRK09772 592022003715 CAT RNA binding domain; Region: CAT_RBD; pfam03123 592022003716 PRD domain; Region: PRD; pfam00874 592022003717 PRD domain; Region: PRD; pfam00874 592022003718 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022003719 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 592022003720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022003721 active site turn [active] 592022003722 phosphorylation site [posttranslational modification] 592022003723 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 592022003724 HPr interaction site; other site 592022003725 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592022003726 active site 592022003727 phosphorylation site [posttranslational modification] 592022003728 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592022003729 dimerization domain swap beta strand [polypeptide binding]; other site 592022003730 regulatory protein interface [polypeptide binding]; other site 592022003731 active site 592022003732 regulatory phosphorylation site [posttranslational modification]; other site 592022003733 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 592022003734 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 592022003735 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592022003736 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 592022003737 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 592022003738 LrgA family; Region: LrgA; pfam03788 592022003739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022003740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022003741 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 592022003742 putative dimerization interface [polypeptide binding]; other site 592022003743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022003744 Coenzyme A binding pocket [chemical binding]; other site 592022003745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022003746 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 592022003747 putative NAD(P) binding site [chemical binding]; other site 592022003748 putative active site [active] 592022003749 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 592022003750 dimer interface [polypeptide binding]; other site 592022003751 FMN binding site [chemical binding]; other site 592022003752 aminotransferase A; Validated; Region: PRK07683 592022003753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022003754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022003755 homodimer interface [polypeptide binding]; other site 592022003756 catalytic residue [active] 592022003757 IDEAL domain; Region: IDEAL; pfam08858 592022003758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022003759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022003760 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 592022003761 putative CheA interaction surface; other site 592022003762 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592022003763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022003764 active site 592022003765 phosphorylation site [posttranslational modification] 592022003766 intermolecular recognition site; other site 592022003767 dimerization interface [polypeptide binding]; other site 592022003768 YkyB-like protein; Region: YkyB; pfam14177 592022003769 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022003770 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592022003771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 592022003772 exopolyphosphatase; Region: exo_poly_only; TIGR03706 592022003773 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 592022003774 polyphosphate kinase; Provisional; Region: PRK05443 592022003775 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 592022003776 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 592022003777 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 592022003778 putative domain interface [polypeptide binding]; other site 592022003779 putative active site [active] 592022003780 catalytic site [active] 592022003781 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 592022003782 putative domain interface [polypeptide binding]; other site 592022003783 putative active site [active] 592022003784 catalytic site [active] 592022003785 phosphodiesterase YaeI; Provisional; Region: PRK11340 592022003786 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 592022003787 putative active site [active] 592022003788 putative metal binding site [ion binding]; other site 592022003789 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 592022003790 short chain dehydrogenase; Provisional; Region: PRK07677 592022003791 NAD(P) binding site [chemical binding]; other site 592022003792 substrate binding site [chemical binding]; other site 592022003793 homotetramer interface [polypeptide binding]; other site 592022003794 active site 592022003795 homodimer interface [polypeptide binding]; other site 592022003796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592022003797 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 592022003798 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 592022003799 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 592022003800 catalytic residues [active] 592022003801 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 592022003802 FOG: CBS domain [General function prediction only]; Region: COG0517 592022003803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 592022003804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022003805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022003806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022003807 dimerization interface [polypeptide binding]; other site 592022003808 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 592022003809 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 592022003810 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 592022003811 active site 592022003812 trimer interface [polypeptide binding]; other site 592022003813 substrate binding site [chemical binding]; other site 592022003814 CoA binding site [chemical binding]; other site 592022003815 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592022003816 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 592022003817 metal binding site [ion binding]; metal-binding site 592022003818 putative dimer interface [polypeptide binding]; other site 592022003819 hypothetical protein; Provisional; Region: PRK03094 592022003820 mechanosensitive channel MscS; Provisional; Region: PRK10334 592022003821 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592022003822 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592022003823 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 592022003824 dimer interface [polypeptide binding]; other site 592022003825 decamer (pentamer of dimers) interface [polypeptide binding]; other site 592022003826 catalytic triad [active] 592022003827 peroxidatic and resolving cysteines [active] 592022003828 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592022003829 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592022003830 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022003831 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 592022003832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592022003833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022003834 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 592022003835 Walker A/P-loop; other site 592022003836 ATP binding site [chemical binding]; other site 592022003837 Q-loop/lid; other site 592022003838 ABC transporter signature motif; other site 592022003839 Walker B; other site 592022003840 D-loop; other site 592022003841 H-loop/switch region; other site 592022003842 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592022003843 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022003844 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 592022003845 Walker A/P-loop; other site 592022003846 ATP binding site [chemical binding]; other site 592022003847 Q-loop/lid; other site 592022003848 ABC transporter signature motif; other site 592022003849 Walker B; other site 592022003850 D-loop; other site 592022003851 H-loop/switch region; other site 592022003852 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 592022003853 TrkA-N domain; Region: TrkA_N; pfam02254 592022003854 TrkA-C domain; Region: TrkA_C; pfam02080 592022003855 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 592022003856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022003857 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 592022003858 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 592022003859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022003860 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022003861 active site 592022003862 motif I; other site 592022003863 motif II; other site 592022003864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022003865 motif II; other site 592022003866 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 592022003867 active site 592022003868 catalytic residues [active] 592022003869 metal binding site [ion binding]; metal-binding site 592022003870 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 592022003871 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 592022003872 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592022003873 TPP-binding site [chemical binding]; other site 592022003874 tetramer interface [polypeptide binding]; other site 592022003875 heterodimer interface [polypeptide binding]; other site 592022003876 phosphorylation loop region [posttranslational modification] 592022003877 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592022003878 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 592022003879 alpha subunit interface [polypeptide binding]; other site 592022003880 TPP binding site [chemical binding]; other site 592022003881 heterodimer interface [polypeptide binding]; other site 592022003882 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592022003883 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 592022003884 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592022003885 E3 interaction surface; other site 592022003886 lipoyl attachment site [posttranslational modification]; other site 592022003887 e3 binding domain; Region: E3_binding; pfam02817 592022003888 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592022003889 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 592022003890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022003891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022003892 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592022003893 BCCT family transporter; Region: BCCT; pfam02028 592022003894 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 592022003895 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 592022003896 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 592022003897 homodimer interface [polypeptide binding]; other site 592022003898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022003899 catalytic residue [active] 592022003900 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 592022003901 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 592022003902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 592022003903 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 592022003904 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 592022003905 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 592022003906 active site 592022003907 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 592022003908 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 592022003909 G1 box; other site 592022003910 putative GEF interaction site [polypeptide binding]; other site 592022003911 GTP/Mg2+ binding site [chemical binding]; other site 592022003912 Switch I region; other site 592022003913 G2 box; other site 592022003914 G3 box; other site 592022003915 Switch II region; other site 592022003916 G4 box; other site 592022003917 G5 box; other site 592022003918 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 592022003919 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 592022003920 YlaH-like protein; Region: YlaH; pfam14036 592022003921 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 592022003922 hypothetical protein; Provisional; Region: PRK06733 592022003923 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 592022003924 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 592022003925 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 592022003926 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 592022003927 putative active site [active] 592022003928 PhoH-like protein; Region: PhoH; pfam02562 592022003929 hypothetical protein; Provisional; Region: PRK13666 592022003930 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 592022003931 pyruvate carboxylase; Reviewed; Region: PRK12999 592022003932 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022003933 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592022003934 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592022003935 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 592022003936 active site 592022003937 catalytic residues [active] 592022003938 metal binding site [ion binding]; metal-binding site 592022003939 homodimer binding site [polypeptide binding]; other site 592022003940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592022003941 carboxyltransferase (CT) interaction site; other site 592022003942 biotinylation site [posttranslational modification]; other site 592022003943 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 592022003944 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 592022003945 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 592022003946 UbiA prenyltransferase family; Region: UbiA; pfam01040 592022003947 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 592022003948 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 592022003949 Cytochrome c; Region: Cytochrom_C; pfam00034 592022003950 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 592022003951 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 592022003952 D-pathway; other site 592022003953 Putative ubiquinol binding site [chemical binding]; other site 592022003954 Low-spin heme (heme b) binding site [chemical binding]; other site 592022003955 Putative water exit pathway; other site 592022003956 Binuclear center (heme o3/CuB) [ion binding]; other site 592022003957 K-pathway; other site 592022003958 Putative proton exit pathway; other site 592022003959 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 592022003960 Subunit I/III interface [polypeptide binding]; other site 592022003961 Subunit III/IV interface [polypeptide binding]; other site 592022003962 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 592022003963 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 592022003964 YugN-like family; Region: YugN; pfam08868 592022003965 FOG: CBS domain [General function prediction only]; Region: COG0517 592022003966 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 592022003967 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 592022003968 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 592022003969 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 592022003970 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 592022003971 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022003972 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022003973 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022003974 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 592022003975 homodimer interface [polypeptide binding]; other site 592022003976 metal binding site [ion binding]; metal-binding site 592022003977 dihydrodipicolinate reductase; Provisional; Region: PRK00048 592022003978 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 592022003979 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 592022003980 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 592022003981 active site 592022003982 dimer interfaces [polypeptide binding]; other site 592022003983 catalytic residues [active] 592022003984 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 592022003985 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 592022003986 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 592022003987 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 592022003988 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 592022003989 active site 592022003990 NTP binding site [chemical binding]; other site 592022003991 metal binding triad [ion binding]; metal-binding site 592022003992 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 592022003993 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 592022003994 Biotin operon repressor [Transcription]; Region: BirA; COG1654 592022003995 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 592022003996 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 592022003997 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 592022003998 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 592022003999 oligomerization interface [polypeptide binding]; other site 592022004000 active site 592022004001 metal binding site [ion binding]; metal-binding site 592022004002 pantoate--beta-alanine ligase; Region: panC; TIGR00018 592022004003 Pantoate-beta-alanine ligase; Region: PanC; cd00560 592022004004 active site 592022004005 ATP-binding site [chemical binding]; other site 592022004006 pantoate-binding site; other site 592022004007 HXXH motif; other site 592022004008 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 592022004009 tetramerization interface [polypeptide binding]; other site 592022004010 active site 592022004011 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 592022004012 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592022004013 active site 592022004014 catalytic site [active] 592022004015 substrate binding site [chemical binding]; other site 592022004016 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 592022004017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022004018 putative Mg++ binding site [ion binding]; other site 592022004019 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 592022004020 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 592022004021 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 592022004022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 592022004023 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022004024 aspartate aminotransferase; Provisional; Region: PRK05764 592022004025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022004026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022004027 homodimer interface [polypeptide binding]; other site 592022004028 catalytic residue [active] 592022004029 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 592022004030 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 592022004031 putative dimer interface [polypeptide binding]; other site 592022004032 putative anticodon binding site; other site 592022004033 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 592022004034 homodimer interface [polypeptide binding]; other site 592022004035 motif 1; other site 592022004036 motif 2; other site 592022004037 active site 592022004038 motif 3; other site 592022004039 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 592022004040 MarR family; Region: MarR_2; cl17246 592022004041 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 592022004042 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 592022004043 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592022004044 minor groove reading motif; other site 592022004045 helix-hairpin-helix signature motif; other site 592022004046 substrate binding pocket [chemical binding]; other site 592022004047 active site 592022004048 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 592022004049 Transglycosylase; Region: Transgly; pfam00912 592022004050 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 592022004051 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022004052 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 592022004053 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 592022004054 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 592022004055 YppF-like protein; Region: YppF; pfam14178 592022004056 YppG-like protein; Region: YppG; pfam14179 592022004057 CotH protein; Region: CotH; pfam08757 592022004058 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 592022004059 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592022004060 homodimer interface [polypeptide binding]; other site 592022004061 substrate-cofactor binding pocket; other site 592022004062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022004063 catalytic residue [active] 592022004064 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 592022004065 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592022004066 homodimer interface [polypeptide binding]; other site 592022004067 substrate-cofactor binding pocket; other site 592022004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022004069 catalytic residue [active] 592022004070 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 592022004071 sodium/proline symporter, frameshift 592022004072 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 592022004073 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 592022004074 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022004075 DNA-binding site [nucleotide binding]; DNA binding site 592022004076 RNA-binding motif; other site 592022004077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592022004078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022004079 metal binding site [ion binding]; metal-binding site 592022004080 active site 592022004081 I-site; other site 592022004082 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 592022004083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022004084 ATP binding site [chemical binding]; other site 592022004085 putative Mg++ binding site [ion binding]; other site 592022004086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022004087 nucleotide binding region [chemical binding]; other site 592022004088 ATP-binding site [chemical binding]; other site 592022004089 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 592022004090 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 592022004091 RNase_H superfamily; Region: RNase_H_2; pfam13482 592022004092 active site 592022004093 substrate binding site [chemical binding]; other site 592022004094 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 592022004095 hypothetical protein; Provisional; Region: PRK13660 592022004096 cell division protein GpsB; Provisional; Region: PRK14127 592022004097 DivIVA domain; Region: DivI1A_domain; TIGR03544 592022004098 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 592022004099 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 592022004100 Predicted membrane protein [Function unknown]; Region: COG4758 592022004101 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 592022004102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592022004103 Histidine kinase; Region: HisKA_3; pfam07730 592022004104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022004105 ATP binding site [chemical binding]; other site 592022004106 Mg2+ binding site [ion binding]; other site 592022004107 G-X-G motif; other site 592022004108 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022004109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022004110 active site 592022004111 phosphorylation site [posttranslational modification] 592022004112 intermolecular recognition site; other site 592022004113 dimerization interface [polypeptide binding]; other site 592022004114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022004115 DNA binding residues [nucleotide binding] 592022004116 dimerization interface [polypeptide binding]; other site 592022004117 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 592022004118 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 592022004119 Ca binding site [ion binding]; other site 592022004120 active site 592022004121 catalytic site [active] 592022004122 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 592022004123 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 592022004124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592022004125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592022004126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004127 dimer interface [polypeptide binding]; other site 592022004128 conserved gate region; other site 592022004129 ABC-ATPase subunit interface; other site 592022004130 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 592022004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004132 dimer interface [polypeptide binding]; other site 592022004133 conserved gate region; other site 592022004134 putative PBP binding loops; other site 592022004135 ABC-ATPase subunit interface; other site 592022004136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022004137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592022004138 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592022004139 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592022004140 Walker A/P-loop; other site 592022004141 ATP binding site [chemical binding]; other site 592022004142 Q-loop/lid; other site 592022004143 ABC transporter signature motif; other site 592022004144 Walker B; other site 592022004145 D-loop; other site 592022004146 H-loop/switch region; other site 592022004147 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 592022004148 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 592022004149 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 592022004150 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 592022004151 active site 592022004152 Zn binding site [ion binding]; other site 592022004153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022004154 active site 592022004155 xanthine permease; Region: pbuX; TIGR03173 592022004156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022004157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022004158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022004159 dimerization interface [polypeptide binding]; other site 592022004160 succinic semialdehyde dehydrogenase; Region: PLN02278 592022004161 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 592022004162 tetramerization interface [polypeptide binding]; other site 592022004163 NAD(P) binding site [chemical binding]; other site 592022004164 catalytic residues [active] 592022004165 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022004166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022004167 Coenzyme A binding pocket [chemical binding]; other site 592022004168 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 592022004169 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 592022004170 malonyl-CoA binding site [chemical binding]; other site 592022004171 dimer interface [polypeptide binding]; other site 592022004172 active site 592022004173 product binding site; other site 592022004174 Phospholipid methyltransferase; Region: PEMT; cl17370 592022004175 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 592022004176 Dynamin family; Region: Dynamin_N; pfam00350 592022004177 G1 box; other site 592022004178 GTP/Mg2+ binding site [chemical binding]; other site 592022004179 G2 box; other site 592022004180 Switch I region; other site 592022004181 G3 box; other site 592022004182 Switch II region; other site 592022004183 G4 box; other site 592022004184 G5 box; other site 592022004185 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 592022004186 Dynamin family; Region: Dynamin_N; pfam00350 592022004187 G1 box; other site 592022004188 GTP/Mg2+ binding site [chemical binding]; other site 592022004189 G2 box; other site 592022004190 Switch I region; other site 592022004191 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 592022004192 G3 box; other site 592022004193 Switch II region; other site 592022004194 GTP/Mg2+ binding site [chemical binding]; other site 592022004195 G4 box; other site 592022004196 G5 box; other site 592022004197 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 592022004198 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 592022004199 Divergent PAP2 family; Region: DUF212; pfam02681 592022004200 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 592022004201 RNA/DNA hybrid binding site [nucleotide binding]; other site 592022004202 active site 592022004203 hypothetical protein; Validated; Region: PRK07708 592022004204 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 592022004205 RNA/DNA hybrid binding site [nucleotide binding]; other site 592022004206 active site 592022004207 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 592022004208 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 592022004209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022004210 DNA-binding site [nucleotide binding]; DNA binding site 592022004211 RNA-binding motif; other site 592022004212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022004214 putative substrate translocation pore; other site 592022004215 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 592022004216 putative active site [active] 592022004217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022004218 TPR motif; other site 592022004219 binding surface 592022004220 TPR repeat; Region: TPR_11; pfam13414 592022004221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022004222 binding surface 592022004223 TPR motif; other site 592022004224 TPR repeat; Region: TPR_11; pfam13414 592022004225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022004226 binding surface 592022004227 TPR motif; other site 592022004228 TPR repeat; Region: TPR_11; pfam13414 592022004229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592022004230 TPR motif; other site 592022004231 binding surface 592022004232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592022004233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022004234 binding surface 592022004235 TPR motif; other site 592022004236 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592022004237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022004238 TPR motif; other site 592022004239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022004240 TPR motif; other site 592022004241 binding surface 592022004242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592022004243 binding surface 592022004244 TPR motif; other site 592022004245 putative uracil/xanthine transporter; Provisional; Region: PRK11412 592022004246 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 592022004247 SxDxEG motif; other site 592022004248 active site 592022004249 metal binding site [ion binding]; metal-binding site 592022004250 homopentamer interface [polypeptide binding]; other site 592022004251 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592022004252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004253 dimer interface [polypeptide binding]; other site 592022004254 conserved gate region; other site 592022004255 putative PBP binding loops; other site 592022004256 ABC-ATPase subunit interface; other site 592022004257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592022004258 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592022004259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004260 dimer interface [polypeptide binding]; other site 592022004261 conserved gate region; other site 592022004262 putative PBP binding loops; other site 592022004263 ABC-ATPase subunit interface; other site 592022004264 dipeptide ABC transporter, ATP-binding protein DppD, frameshift 592022004265 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 592022004266 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 592022004267 peptide binding site [polypeptide binding]; other site 592022004268 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 592022004269 dimer interface [polypeptide binding]; other site 592022004270 catalytic triad [active] 592022004271 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022004272 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022004273 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 592022004274 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022004275 Walker A/P-loop; other site 592022004276 ATP binding site [chemical binding]; other site 592022004277 Q-loop/lid; other site 592022004278 ABC transporter signature motif; other site 592022004279 Walker B; other site 592022004280 D-loop; other site 592022004281 H-loop/switch region; other site 592022004282 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592022004283 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 592022004284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022004285 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022004286 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 592022004287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004288 PAS domain S-box; Region: sensory_box; TIGR00229 592022004289 PAS domain S-box; Region: sensory_box; TIGR00229 592022004290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022004291 putative active site [active] 592022004292 heme pocket [chemical binding]; other site 592022004293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592022004294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022004295 metal binding site [ion binding]; metal-binding site 592022004296 active site 592022004297 I-site; other site 592022004298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592022004299 Uncharacterized conserved protein [Function unknown]; Region: COG0398 592022004300 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022004301 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 592022004302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022004303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022004304 active site 592022004305 phosphorylation site [posttranslational modification] 592022004306 intermolecular recognition site; other site 592022004307 dimerization interface [polypeptide binding]; other site 592022004308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022004309 DNA binding residues [nucleotide binding] 592022004310 dimerization interface [polypeptide binding]; other site 592022004311 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592022004312 Histidine kinase; Region: HisKA_3; pfam07730 592022004313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022004314 ATP binding site [chemical binding]; other site 592022004315 Mg2+ binding site [ion binding]; other site 592022004316 G-X-G motif; other site 592022004317 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 592022004318 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 592022004319 putative di-iron ligands [ion binding]; other site 592022004320 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 592022004321 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 592022004322 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 592022004323 putative active site [active] 592022004324 catalytic site [active] 592022004325 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 592022004326 putative active site [active] 592022004327 catalytic site [active] 592022004328 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 592022004329 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 592022004330 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022004331 Bacterial SH3 domain; Region: SH3_3; cl17532 592022004332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022004333 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 592022004334 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022004335 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 592022004336 active site 592022004337 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 592022004338 glycosyltransferase, MGT family; Region: MGT; TIGR01426 592022004339 active site 592022004340 TDP-binding site; other site 592022004341 acceptor substrate-binding pocket; other site 592022004342 homodimer interface [polypeptide binding]; other site 592022004343 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592022004344 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 592022004345 active site 592022004346 tetramer interface; other site 592022004347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004348 sugar efflux transporter; Region: 2A0120; TIGR00899 592022004349 putative substrate translocation pore; other site 592022004350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022004352 putative substrate translocation pore; other site 592022004353 Protein of unknown function, DUF393; Region: DUF393; pfam04134 592022004354 short chain dehydrogenase; Provisional; Region: PRK06197 592022004355 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 592022004356 putative NAD(P) binding site [chemical binding]; other site 592022004357 active site 592022004358 dihydroorotase; Provisional; Region: PRK09237 592022004359 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 592022004360 active site 592022004361 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592022004362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022004363 catalytic residue [active] 592022004364 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 592022004365 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592022004366 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022004367 substrate binding site [chemical binding]; other site 592022004368 ATP binding site [chemical binding]; other site 592022004369 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 592022004370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022004371 DNA-binding site [nucleotide binding]; DNA binding site 592022004372 UTRA domain; Region: UTRA; pfam07702 592022004373 GntP family permease; Region: GntP_permease; pfam02447 592022004374 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022004375 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 592022004376 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 592022004377 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022004378 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022004379 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 592022004380 dimer interface [polypeptide binding]; other site 592022004381 Alkaline phosphatase homologues; Region: alkPPc; smart00098 592022004382 active site 592022004383 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 592022004384 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 592022004385 catalytic residues [active] 592022004386 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 592022004387 active site 592022004388 catalytic residues [active] 592022004389 Endonuclease I; Region: Endonuclease_1; cl01003 592022004390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022004391 MarR family; Region: MarR_2; pfam12802 592022004392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592022004393 E3 interaction surface; other site 592022004394 lipoyl attachment site [posttranslational modification]; other site 592022004395 HlyD family secretion protein; Region: HlyD_3; pfam13437 592022004396 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022004397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004398 putative substrate translocation pore; other site 592022004399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004400 MarR family; Region: MarR_2; cl17246 592022004401 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022004402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022004403 non-specific DNA binding site [nucleotide binding]; other site 592022004404 salt bridge; other site 592022004405 sequence-specific DNA binding site [nucleotide binding]; other site 592022004406 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 592022004407 YfhD-like protein; Region: YfhD; pfam14151 592022004408 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592022004409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022004410 ABC-ATPase subunit interface; other site 592022004411 dimer interface [polypeptide binding]; other site 592022004412 putative PBP binding regions; other site 592022004413 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592022004414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022004415 ABC-ATPase subunit interface; other site 592022004416 dimer interface [polypeptide binding]; other site 592022004417 putative PBP binding regions; other site 592022004418 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 592022004419 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592022004420 putative ligand binding residues [chemical binding]; other site 592022004421 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 592022004422 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592022004423 Walker A/P-loop; other site 592022004424 ATP binding site [chemical binding]; other site 592022004425 Q-loop/lid; other site 592022004426 ABC transporter signature motif; other site 592022004427 Walker B; other site 592022004428 D-loop; other site 592022004429 H-loop/switch region; other site 592022004430 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592022004431 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022004432 methionine gamma-lyase; Provisional; Region: PRK06767 592022004433 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592022004434 homodimer interface [polypeptide binding]; other site 592022004435 substrate-cofactor binding pocket; other site 592022004436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022004437 catalytic residue [active] 592022004438 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 592022004439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004440 putative substrate translocation pore; other site 592022004441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022004442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022004443 active site 592022004444 catalytic tetrad [active] 592022004445 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 592022004446 active site 2 [active] 592022004447 active site 1 [active] 592022004448 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 592022004449 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 592022004450 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 592022004451 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022004452 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592022004453 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 592022004454 active site 592022004455 dimer interface [polypeptide binding]; other site 592022004456 magnesium binding site [ion binding]; other site 592022004457 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592022004458 hydroxyglutarate oxidase; Provisional; Region: PRK11728 592022004459 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 592022004460 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 592022004461 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 592022004462 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 592022004463 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592022004464 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 592022004465 [2Fe-2S] cluster binding site [ion binding]; other site 592022004466 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 592022004467 putative alpha subunit interface [polypeptide binding]; other site 592022004468 putative active site [active] 592022004469 putative substrate binding site [chemical binding]; other site 592022004470 Fe binding site [ion binding]; other site 592022004471 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 592022004472 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 592022004473 Walker A/P-loop; other site 592022004474 ATP binding site [chemical binding]; other site 592022004475 Q-loop/lid; other site 592022004476 ABC transporter signature motif; other site 592022004477 Walker B; other site 592022004478 D-loop; other site 592022004479 H-loop/switch region; other site 592022004480 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 592022004481 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 592022004482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004483 dimer interface [polypeptide binding]; other site 592022004484 conserved gate region; other site 592022004485 ABC-ATPase subunit interface; other site 592022004486 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 592022004487 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 592022004488 pyruvate kinase; Validated; Region: PRK06739 592022004489 active site 592022004490 domain interfaces; other site 592022004491 CHASE3 domain; Region: CHASE3; pfam05227 592022004492 HAMP domain; Region: HAMP; pfam00672 592022004493 dimerization interface [polypeptide binding]; other site 592022004494 GAF domain; Region: GAF_2; pfam13185 592022004495 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592022004496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022004497 dimer interface [polypeptide binding]; other site 592022004498 phosphorylation site [posttranslational modification] 592022004499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022004500 ATP binding site [chemical binding]; other site 592022004501 Mg2+ binding site [ion binding]; other site 592022004502 G-X-G motif; other site 592022004503 Response regulator receiver domain; Region: Response_reg; pfam00072 592022004504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022004505 active site 592022004506 phosphorylation site [posttranslational modification] 592022004507 intermolecular recognition site; other site 592022004508 dimerization interface [polypeptide binding]; other site 592022004509 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 592022004510 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 592022004511 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 592022004512 Response regulator receiver domain; Region: Response_reg; pfam00072 592022004513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022004514 active site 592022004515 phosphorylation site [posttranslational modification] 592022004516 intermolecular recognition site; other site 592022004517 dimerization interface [polypeptide binding]; other site 592022004518 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 592022004519 LysE type translocator; Region: LysE; pfam01810 592022004520 amino acid transporter; Region: 2A0306; TIGR00909 592022004521 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 592022004522 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592022004523 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592022004524 ligand binding site [chemical binding]; other site 592022004525 flexible hinge region; other site 592022004526 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592022004527 putative switch regulator; other site 592022004528 non-specific DNA interactions [nucleotide binding]; other site 592022004529 DNA binding site [nucleotide binding] 592022004530 sequence specific DNA binding site [nucleotide binding]; other site 592022004531 putative cAMP binding site [chemical binding]; other site 592022004532 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 592022004533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022004534 active site 592022004535 motif I; other site 592022004536 motif II; other site 592022004537 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 592022004538 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 592022004539 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 592022004540 active site 592022004541 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 592022004542 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592022004543 substrate binding [chemical binding]; other site 592022004544 active site 592022004545 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 592022004546 Ferritin-like domain; Region: Ferritin; pfam00210 592022004547 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 592022004548 dinuclear metal binding motif [ion binding]; other site 592022004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004550 putative substrate translocation pore; other site 592022004551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022004552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004553 putative substrate translocation pore; other site 592022004554 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592022004555 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 592022004556 substrate-cofactor binding pocket; other site 592022004557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022004558 catalytic residue [active] 592022004559 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592022004560 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 592022004561 NAD binding site [chemical binding]; other site 592022004562 homodimer interface [polypeptide binding]; other site 592022004563 active site 592022004564 putative substrate binding site [chemical binding]; other site 592022004565 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 592022004566 hexamer interface [polypeptide binding]; other site 592022004567 RNA binding site [nucleotide binding]; other site 592022004568 Histidine-zinc binding site [chemical binding]; other site 592022004569 benzoate transport; Region: 2A0115; TIGR00895 592022004570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004571 putative substrate translocation pore; other site 592022004572 ThiJ/PfpI family protein, frameshift 592022004573 Uncharacterized conserved protein [Function unknown]; Region: COG1359 592022004574 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 592022004575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022004576 NAD binding site [chemical binding]; other site 592022004577 catalytic residues [active] 592022004578 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022004579 LysE type translocator; Region: LysE; pfam01810 592022004580 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 592022004581 Spore germination protein; Region: Spore_permease; cl17796 592022004582 YpzG-like protein; Region: YpzG; pfam14139 592022004583 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 592022004584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022004585 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 592022004586 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 592022004587 putative transport protein YifK; Provisional; Region: PRK10746 592022004588 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022004589 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022004590 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022004591 DNA binding site [nucleotide binding] 592022004592 domain linker motif; other site 592022004593 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 592022004594 dimerization interface [polypeptide binding]; other site 592022004595 ligand binding site [chemical binding]; other site 592022004596 sodium binding site [ion binding]; other site 592022004597 galactoside permease; Reviewed; Region: lacY; PRK09528 592022004598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004599 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 592022004600 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592022004601 substrate binding [chemical binding]; other site 592022004602 active site 592022004603 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 592022004604 Uncharacterized conserved protein [Function unknown]; Region: COG0397 592022004605 hypothetical protein; Validated; Region: PRK00029 592022004606 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 592022004607 active site 592022004608 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 592022004609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022004610 Walker A motif; other site 592022004611 ATP binding site [chemical binding]; other site 592022004612 Walker B motif; other site 592022004613 arginine finger; other site 592022004614 Transcriptional antiterminator [Transcription]; Region: COG3933 592022004615 PRD domain; Region: PRD; pfam00874 592022004616 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 592022004617 active pocket/dimerization site; other site 592022004618 active site 592022004619 phosphorylation site [posttranslational modification] 592022004620 PRD domain; Region: PRD; pfam00874 592022004621 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 592022004622 active pocket/dimerization site; other site 592022004623 active site 592022004624 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 592022004625 active site 592022004626 phosphorylation site [posttranslational modification] 592022004627 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 592022004628 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 592022004629 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 592022004630 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592022004631 substrate binding [chemical binding]; other site 592022004632 active site 592022004633 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 592022004634 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 592022004635 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592022004636 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 592022004637 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 592022004638 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592022004639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004640 dimer interface [polypeptide binding]; other site 592022004641 conserved gate region; other site 592022004642 putative PBP binding loops; other site 592022004643 ABC-ATPase subunit interface; other site 592022004644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004645 dimer interface [polypeptide binding]; other site 592022004646 conserved gate region; other site 592022004647 putative PBP binding loops; other site 592022004648 ABC-ATPase subunit interface; other site 592022004649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592022004650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022004651 substrate binding pocket [chemical binding]; other site 592022004652 membrane-bound complex binding site; other site 592022004653 hinge residues; other site 592022004654 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592022004655 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592022004656 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592022004657 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 592022004658 Walker A/P-loop; other site 592022004659 ATP binding site [chemical binding]; other site 592022004660 Q-loop/lid; other site 592022004661 ABC transporter signature motif; other site 592022004662 Walker B; other site 592022004663 D-loop; other site 592022004664 H-loop/switch region; other site 592022004665 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 592022004666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004667 ABC-ATPase subunit interface; other site 592022004668 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022004669 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592022004670 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592022004671 active site 592022004672 non-prolyl cis peptide bond; other site 592022004673 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 592022004674 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592022004675 Flavin binding site [chemical binding]; other site 592022004676 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592022004677 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592022004678 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592022004679 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 592022004680 Walker A/P-loop; other site 592022004681 ATP binding site [chemical binding]; other site 592022004682 Q-loop/lid; other site 592022004683 ABC transporter signature motif; other site 592022004684 Walker B; other site 592022004685 D-loop; other site 592022004686 H-loop/switch region; other site 592022004687 NIL domain; Region: NIL; pfam09383 592022004688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004689 dimer interface [polypeptide binding]; other site 592022004690 conserved gate region; other site 592022004691 ABC-ATPase subunit interface; other site 592022004692 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592022004693 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592022004694 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592022004695 active site 592022004696 non-prolyl cis peptide bond; other site 592022004697 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592022004698 active site 592022004699 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 592022004700 putative deacylase active site [active] 592022004701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022004702 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022004703 active site 592022004704 catalytic tetrad [active] 592022004705 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 592022004706 active sites [active] 592022004707 tetramer interface [polypeptide binding]; other site 592022004708 urocanate hydratase; Provisional; Region: PRK05414 592022004709 imidazolonepropionase; Validated; Region: PRK09356 592022004710 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 592022004711 active site 592022004712 Agmatinase-like family; Region: Agmatinase-like; cd09990 592022004713 active site 592022004714 oligomer interface [polypeptide binding]; other site 592022004715 Mn binding site [ion binding]; other site 592022004716 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 592022004717 active site 592022004718 tetramer interface [polypeptide binding]; other site 592022004719 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 592022004720 tartrate dehydrogenase; Region: TTC; TIGR02089 592022004721 Predicted membrane protein [Function unknown]; Region: COG1288 592022004722 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 592022004723 isoaspartyl dipeptidase; Provisional; Region: PRK10657 592022004724 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592022004725 active site 592022004726 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 592022004727 proposed catalytic triad [active] 592022004728 active site nucleophile [active] 592022004729 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 592022004730 proposed catalytic triad [active] 592022004731 active site nucleophile [active] 592022004732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 592022004733 putative active site [active] 592022004734 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 592022004735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022004736 Walker A motif; other site 592022004737 ATP binding site [chemical binding]; other site 592022004738 Walker B motif; other site 592022004739 arginine finger; other site 592022004740 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 592022004741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004742 putative substrate translocation pore; other site 592022004743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022004744 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592022004745 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 592022004746 acetyltransferase, GNAT family, frameshift 592022004747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022004748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022004749 Coenzyme A binding pocket [chemical binding]; other site 592022004750 methyltransferase, frameshift 592022004751 Predicted membrane protein [Function unknown]; Region: COG2364 592022004752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022004753 MarR family; Region: MarR; pfam01047 592022004754 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022004755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022004756 Coenzyme A binding pocket [chemical binding]; other site 592022004757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022004758 putative DNA binding site [nucleotide binding]; other site 592022004759 dimerization interface [polypeptide binding]; other site 592022004760 putative Zn2+ binding site [ion binding]; other site 592022004761 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 592022004762 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 592022004763 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592022004764 potential catalytic triad [active] 592022004765 conserved cys residue [active] 592022004766 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 592022004767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022004768 motif II; other site 592022004769 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 592022004770 nudix motif; other site 592022004771 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 592022004772 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 592022004773 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022004774 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022004775 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022004776 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022004777 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 592022004778 Uncharacterized conserved protein [Function unknown]; Region: COG1434 592022004779 putative active site [active] 592022004780 DinB family; Region: DinB; cl17821 592022004781 DinB superfamily; Region: DinB_2; pfam12867 592022004782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022004783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022004784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022004785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022004786 dimerization interface [polypeptide binding]; other site 592022004787 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022004788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592022004789 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022004790 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 592022004791 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 592022004792 classical (c) SDRs; Region: SDR_c; cd05233 592022004793 NAD(P) binding site [chemical binding]; other site 592022004794 active site 592022004795 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 592022004796 active site 592022004797 ATP binding site [chemical binding]; other site 592022004798 Phosphotransferase enzyme family; Region: APH; pfam01636 592022004799 substrate binding site [chemical binding]; other site 592022004800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022004801 HAMP domain; Region: HAMP; pfam00672 592022004802 dimerization interface [polypeptide binding]; other site 592022004803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022004804 dimer interface [polypeptide binding]; other site 592022004805 phosphorylation site [posttranslational modification] 592022004806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022004807 ATP binding site [chemical binding]; other site 592022004808 Mg2+ binding site [ion binding]; other site 592022004809 G-X-G motif; other site 592022004810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022004811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022004812 active site 592022004813 phosphorylation site [posttranslational modification] 592022004814 intermolecular recognition site; other site 592022004815 dimerization interface [polypeptide binding]; other site 592022004816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022004817 DNA binding site [nucleotide binding] 592022004818 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592022004819 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022004820 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 592022004821 active site 592022004822 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 592022004823 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 592022004824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592022004825 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 592022004826 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022004827 NodB motif; other site 592022004828 putative active site [active] 592022004829 putative catalytic site [active] 592022004830 putative Zn binding site [ion binding]; other site 592022004831 Spore germination protein; Region: Spore_permease; cl17796 592022004832 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 592022004833 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 592022004834 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 592022004835 calcium/proton exchanger (cax); Region: cax; TIGR00378 592022004836 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592022004837 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592022004838 FOG: CBS domain [General function prediction only]; Region: COG0517 592022004839 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 592022004840 PAS fold; Region: PAS; pfam00989 592022004841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022004842 putative active site [active] 592022004843 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592022004844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022004845 Walker A motif; other site 592022004846 ATP binding site [chemical binding]; other site 592022004847 Walker B motif; other site 592022004848 arginine finger; other site 592022004849 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592022004850 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592022004851 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 592022004852 putative active site [active] 592022004853 metal binding site [ion binding]; metal-binding site 592022004854 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 592022004855 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 592022004856 tetrameric interface [polypeptide binding]; other site 592022004857 NAD binding site [chemical binding]; other site 592022004858 catalytic residues [active] 592022004859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022004860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022004861 DNA binding site [nucleotide binding] 592022004862 domain linker motif; other site 592022004863 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 592022004864 putative dimerization interface [polypeptide binding]; other site 592022004865 putative ligand binding site [chemical binding]; other site 592022004866 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 592022004867 histidinol dehydrogenase; Region: hisD; TIGR00069 592022004868 NAD binding site [chemical binding]; other site 592022004869 dimerization interface [polypeptide binding]; other site 592022004870 product binding site; other site 592022004871 substrate binding site [chemical binding]; other site 592022004872 zinc binding site [ion binding]; other site 592022004873 catalytic residues [active] 592022004874 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 592022004875 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022004876 classical (c) SDRs; Region: SDR_c; cd05233 592022004877 NAD(P) binding site [chemical binding]; other site 592022004878 active site 592022004879 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 592022004880 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592022004881 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592022004882 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592022004883 EamA-like transporter family; Region: EamA; pfam00892 592022004884 EamA-like transporter family; Region: EamA; pfam00892 592022004885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022004886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022004887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022004888 dimerization interface [polypeptide binding]; other site 592022004889 MMPL family; Region: MMPL; pfam03176 592022004890 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 592022004891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022004892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022004893 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 592022004894 Coat F domain; Region: Coat_F; cl17715 592022004895 Heat induced stress protein YflT; Region: YflT; pfam11181 592022004896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022004897 PAS domain; Region: PAS_9; pfam13426 592022004898 putative active site [active] 592022004899 heme pocket [chemical binding]; other site 592022004900 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022004901 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 592022004902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022004903 putative DNA binding site [nucleotide binding]; other site 592022004904 putative Zn2+ binding site [ion binding]; other site 592022004905 AsnC family; Region: AsnC_trans_reg; pfam01037 592022004906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 592022004907 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 592022004908 DinB family; Region: DinB; cl17821 592022004909 DinB superfamily; Region: DinB_2; pfam12867 592022004910 Bacterial SH3 domain; Region: SH3_3; cl17532 592022004911 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 592022004912 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 592022004913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022004914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022004915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592022004916 dimerization interface [polypeptide binding]; other site 592022004917 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022004918 DNA-binding site [nucleotide binding]; DNA binding site 592022004919 RNA-binding motif; other site 592022004920 acetolactate synthase; Reviewed; Region: PRK08322 592022004921 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592022004922 PYR/PP interface [polypeptide binding]; other site 592022004923 dimer interface [polypeptide binding]; other site 592022004924 TPP binding site [chemical binding]; other site 592022004925 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022004926 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 592022004927 TPP-binding site [chemical binding]; other site 592022004928 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 592022004929 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 592022004930 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 592022004931 Small acid-soluble spore protein H family; Region: SspH; pfam08141 592022004932 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 592022004933 dihydrodipicolinate synthase; Region: dapA; TIGR00674 592022004934 dimer interface [polypeptide binding]; other site 592022004935 active site 592022004936 catalytic residue [active] 592022004937 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592022004938 EamA-like transporter family; Region: EamA; pfam00892 592022004939 FOG: CBS domain [General function prediction only]; Region: COG0517 592022004940 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 592022004941 Predicted membrane protein [Function unknown]; Region: COG2323 592022004942 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 592022004943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004944 putative substrate translocation pore; other site 592022004945 glutamate dehydrogenase; Provisional; Region: PRK09414 592022004946 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592022004947 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 592022004948 NAD(P) binding site [chemical binding]; other site 592022004949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022004950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022004951 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 592022004952 putative dimerization interface [polypeptide binding]; other site 592022004953 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592022004954 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 592022004955 substrate binding site [chemical binding]; other site 592022004956 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 592022004957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004958 dimer interface [polypeptide binding]; other site 592022004959 conserved gate region; other site 592022004960 putative PBP binding loops; other site 592022004961 ABC-ATPase subunit interface; other site 592022004962 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592022004963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022004964 dimer interface [polypeptide binding]; other site 592022004965 conserved gate region; other site 592022004966 putative PBP binding loops; other site 592022004967 ABC-ATPase subunit interface; other site 592022004968 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022004969 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 592022004970 Walker A/P-loop; other site 592022004971 ATP binding site [chemical binding]; other site 592022004972 Q-loop/lid; other site 592022004973 ABC transporter signature motif; other site 592022004974 Walker B; other site 592022004975 D-loop; other site 592022004976 H-loop/switch region; other site 592022004977 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592022004978 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 592022004979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022004980 Walker A/P-loop; other site 592022004981 ATP binding site [chemical binding]; other site 592022004982 Q-loop/lid; other site 592022004983 ABC transporter signature motif; other site 592022004984 Walker B; other site 592022004985 D-loop; other site 592022004986 H-loop/switch region; other site 592022004987 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 592022004988 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 592022004989 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 592022004990 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 592022004991 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 592022004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 592022004993 transcriptional regulator, GntR family, frameshift 592022004994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022004995 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022004996 putative substrate translocation pore; other site 592022004997 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 592022004998 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022004999 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022005000 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 592022005001 active site 592022005002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 592022005003 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592022005004 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 592022005005 active site 592022005006 catalytic residues [active] 592022005007 metal binding site [ion binding]; metal-binding site 592022005008 Predicted membrane protein [Function unknown]; Region: COG2855 592022005009 Beta-lactamase; Region: Beta-lactamase; cl17358 592022005010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592022005011 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592022005012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022005013 S-adenosylmethionine binding site [chemical binding]; other site 592022005014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 592022005015 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022005016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022005017 dimerization interface [polypeptide binding]; other site 592022005018 putative Zn2+ binding site [ion binding]; other site 592022005019 putative DNA binding site [nucleotide binding]; other site 592022005020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022005021 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592022005022 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 592022005023 putative active site [active] 592022005024 catalytic triad [active] 592022005025 putative dimer interface [polypeptide binding]; other site 592022005026 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022005027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022005028 Coenzyme A binding pocket [chemical binding]; other site 592022005029 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 592022005030 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 592022005031 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 592022005032 hexamer interface [polypeptide binding]; other site 592022005033 Walker A motif; other site 592022005034 ATP binding site [chemical binding]; other site 592022005035 Walker B motif; other site 592022005036 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 592022005037 Low molecular weight phosphatase family; Region: LMWPc; cd00115 592022005038 active site 592022005039 arsenical pump membrane protein, frameshift 592022005040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 592022005041 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022005042 DNA-binding site [nucleotide binding]; DNA binding site 592022005043 RNA-binding motif; other site 592022005044 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 592022005045 ZIP Zinc transporter; Region: Zip; pfam02535 592022005046 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 592022005047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 592022005048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022005050 putative substrate translocation pore; other site 592022005051 MarR family; Region: MarR; pfam01047 592022005052 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 592022005053 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 592022005054 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 592022005055 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 592022005056 Spore germination protein; Region: Spore_permease; pfam03845 592022005057 Spore germination protein; Region: Spore_permease; pfam03845 592022005058 Spore germination protein; Region: Spore_permease; pfam03845 592022005059 putative spore germination protein, frameshift 592022005060 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022005061 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 592022005062 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 592022005063 DNA binding residues [nucleotide binding] 592022005064 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 592022005065 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 592022005066 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 592022005067 TrkA-N domain; Region: TrkA_N; pfam02254 592022005068 Amino acid permease; Region: AA_permease_2; pfam13520 592022005069 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 592022005070 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005071 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 592022005072 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 592022005073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022005074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022005075 dimerization interface [polypeptide binding]; other site 592022005076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022005077 dimer interface [polypeptide binding]; other site 592022005078 phosphorylation site [posttranslational modification] 592022005079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022005080 ATP binding site [chemical binding]; other site 592022005081 Mg2+ binding site [ion binding]; other site 592022005082 G-X-G motif; other site 592022005083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022005085 active site 592022005086 phosphorylation site [posttranslational modification] 592022005087 intermolecular recognition site; other site 592022005088 dimerization interface [polypeptide binding]; other site 592022005089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022005090 DNA binding site [nucleotide binding] 592022005091 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592022005092 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592022005093 Protein export membrane protein; Region: SecD_SecF; cl14618 592022005094 Protein export membrane protein; Region: SecD_SecF; cl14618 592022005095 S-methylmethionine transporter; Provisional; Region: PRK11387 592022005096 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 592022005097 hexamer interface [polypeptide binding]; other site 592022005098 RNA binding site [nucleotide binding]; other site 592022005099 Histidine-zinc binding site [chemical binding]; other site 592022005100 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 592022005101 active sites [active] 592022005102 tetramer interface [polypeptide binding]; other site 592022005103 urocanate hydratase; Provisional; Region: PRK05414 592022005104 imidazolonepropionase; Validated; Region: PRK09356 592022005105 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 592022005106 active site 592022005107 Agmatinase-like family; Region: Agmatinase-like; cd09990 592022005108 active site 592022005109 oligomer interface [polypeptide binding]; other site 592022005110 Mn binding site [ion binding]; other site 592022005111 D-galactonate transporter; Region: 2A0114; TIGR00893 592022005112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005113 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 592022005114 active site 592022005115 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 592022005116 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 592022005117 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022005118 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022005119 aspartate ammonia-lyase; Provisional; Region: PRK14515 592022005120 Aspartase; Region: Aspartase; cd01357 592022005121 active sites [active] 592022005122 tetramer interface [polypeptide binding]; other site 592022005123 Coat F domain; Region: Coat_F; cl17715 592022005124 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005125 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 592022005126 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022005127 potential frameshift: common BLAST hit: gi|261419734|ref|YP_003253416.1| protein of unknown function DUF159 592022005128 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 592022005129 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 592022005130 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005131 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 592022005132 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005133 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005134 glucose-1-dehydrogenase; Provisional; Region: PRK08936 592022005135 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 592022005136 NAD binding site [chemical binding]; other site 592022005137 homodimer interface [polypeptide binding]; other site 592022005138 active site 592022005139 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 592022005140 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 592022005141 Ca binding site [ion binding]; other site 592022005142 active site 592022005143 catalytic site [active] 592022005144 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022005145 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 592022005146 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005147 FOG: CBS domain [General function prediction only]; Region: COG0517 592022005148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 592022005149 Domain of unknown function DUF77; Region: DUF77; pfam01910 592022005150 Heat induced stress protein YflT; Region: YflT; pfam11181 592022005151 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022005152 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022005153 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022005154 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022005155 Copper resistance protein D; Region: CopD; pfam05425 592022005156 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 592022005157 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 592022005158 Predicted permeases [General function prediction only]; Region: COG0701 592022005159 TIGR03943 family protein; Region: TIGR03943 592022005160 Predicted permeases [General function prediction only]; Region: COG0701 592022005161 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592022005162 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592022005163 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592022005164 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022005165 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022005166 C4-type Zn-finger protein [General function prediction only]; Region: COG1779 592022005167 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 592022005168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022005169 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 592022005170 phosphoenolpyruvate synthase; Validated; Region: PRK06241 592022005171 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 592022005172 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592022005173 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 592022005174 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 592022005175 catalytic triad [active] 592022005176 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592022005177 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592022005178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592022005179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022005180 dimer interface [polypeptide binding]; other site 592022005181 conserved gate region; other site 592022005182 putative PBP binding loops; other site 592022005183 ABC-ATPase subunit interface; other site 592022005184 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592022005185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022005186 dimer interface [polypeptide binding]; other site 592022005187 conserved gate region; other site 592022005188 putative PBP binding loops; other site 592022005189 ABC-ATPase subunit interface; other site 592022005190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592022005191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022005192 Walker A/P-loop; other site 592022005193 ATP binding site [chemical binding]; other site 592022005194 Q-loop/lid; other site 592022005195 ABC transporter signature motif; other site 592022005196 Walker B; other site 592022005197 D-loop; other site 592022005198 H-loop/switch region; other site 592022005199 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592022005200 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 592022005201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022005202 Walker A/P-loop; other site 592022005203 ATP binding site [chemical binding]; other site 592022005204 Q-loop/lid; other site 592022005205 ABC transporter signature motif; other site 592022005206 Walker B; other site 592022005207 D-loop; other site 592022005208 H-loop/switch region; other site 592022005209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592022005210 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 592022005211 putative deacylase active site [active] 592022005212 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 592022005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005214 putative substrate translocation pore; other site 592022005215 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 592022005216 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022005217 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 592022005218 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 592022005219 tetrameric interface [polypeptide binding]; other site 592022005220 activator binding site; other site 592022005221 NADP binding site [chemical binding]; other site 592022005222 substrate binding site [chemical binding]; other site 592022005223 catalytic residues [active] 592022005224 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 592022005225 active site 592022005226 intersubunit interactions; other site 592022005227 catalytic residue [active] 592022005228 metal-dependent hydrolase; Provisional; Region: PRK13291 592022005229 DinB superfamily; Region: DinB_2; pfam12867 592022005230 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 592022005231 active site 592022005232 catalytic residues [active] 592022005233 FOG: CBS domain [General function prediction only]; Region: COG0517 592022005234 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 592022005235 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592022005236 Cytochrome P450; Region: p450; cl12078 592022005237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022005238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022005239 Transcriptional regulators [Transcription]; Region: MarR; COG1846 592022005240 MarR family; Region: MarR_2; pfam12802 592022005241 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592022005242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592022005243 nucleotide binding site [chemical binding]; other site 592022005244 xylose isomerase; Provisional; Region: PRK05474 592022005245 xylose isomerase; Region: xylose_isom_A; TIGR02630 592022005246 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 592022005247 N- and C-terminal domain interface [polypeptide binding]; other site 592022005248 D-xylulose kinase; Region: XylB; TIGR01312 592022005249 active site 592022005250 MgATP binding site [chemical binding]; other site 592022005251 catalytic site [active] 592022005252 metal binding site [ion binding]; metal-binding site 592022005253 xylulose binding site [chemical binding]; other site 592022005254 homodimer interface [polypeptide binding]; other site 592022005255 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 592022005256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005257 putative substrate translocation pore; other site 592022005258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005259 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 592022005260 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 592022005261 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 592022005262 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 592022005263 D-pathway; other site 592022005264 Putative ubiquinol binding site [chemical binding]; other site 592022005265 Low-spin heme (heme b) binding site [chemical binding]; other site 592022005266 Putative water exit pathway; other site 592022005267 Binuclear center (heme o3/CuB) [ion binding]; other site 592022005268 K-pathway; other site 592022005269 Putative proton exit pathway; other site 592022005270 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 592022005271 Subunit I/III interface [polypeptide binding]; other site 592022005272 Subunit III/IV interface [polypeptide binding]; other site 592022005273 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 592022005274 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592022005275 Ligand Binding Site [chemical binding]; other site 592022005276 oxidoreductase; Provisional; Region: PRK07985 592022005277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022005278 NAD(P) binding site [chemical binding]; other site 592022005279 active site 592022005280 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 592022005281 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 592022005282 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 592022005283 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 592022005284 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592022005285 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 592022005286 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 592022005287 transmembrane helices; other site 592022005288 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 592022005289 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592022005290 tetramer interface [polypeptide binding]; other site 592022005291 TPP-binding site [chemical binding]; other site 592022005292 heterodimer interface [polypeptide binding]; other site 592022005293 phosphorylation loop region [posttranslational modification] 592022005294 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592022005295 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 592022005296 alpha subunit interface [polypeptide binding]; other site 592022005297 TPP binding site [chemical binding]; other site 592022005298 heterodimer interface [polypeptide binding]; other site 592022005299 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592022005300 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 592022005301 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592022005302 E3 interaction surface; other site 592022005303 lipoyl attachment site [posttranslational modification]; other site 592022005304 e3 binding domain; Region: E3_binding; pfam02817 592022005305 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592022005306 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 592022005307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022005308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022005309 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592022005310 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 592022005311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022005312 Walker A motif; other site 592022005313 ATP binding site [chemical binding]; other site 592022005314 Walker B motif; other site 592022005315 arginine finger; other site 592022005316 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592022005317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592022005318 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 592022005319 putative NAD(P) binding site [chemical binding]; other site 592022005320 catalytic Zn binding site [ion binding]; other site 592022005321 cystathionine gamma-synthase; Provisional; Region: PRK08249 592022005322 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592022005323 homodimer interface [polypeptide binding]; other site 592022005324 substrate-cofactor binding pocket; other site 592022005325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022005326 catalytic residue [active] 592022005327 transcriptional regulator Hpr; Provisional; Region: PRK13777 592022005328 MarR family; Region: MarR; pfam01047 592022005329 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022005330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022005331 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022005332 active site 592022005333 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592022005334 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592022005335 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 592022005336 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 592022005337 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 592022005338 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 592022005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005340 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 592022005341 putative substrate translocation pore; other site 592022005342 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 592022005343 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 592022005344 CoA-transferase family III; Region: CoA_transf_3; pfam02515 592022005345 IDEAL domain; Region: IDEAL; pfam08858 592022005346 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592022005347 Ligand Binding Site [chemical binding]; other site 592022005348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022005349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022005350 dimerization interface [polypeptide binding]; other site 592022005351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022005352 dimer interface [polypeptide binding]; other site 592022005353 phosphorylation site [posttranslational modification] 592022005354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022005355 ATP binding site [chemical binding]; other site 592022005356 Mg2+ binding site [ion binding]; other site 592022005357 G-X-G motif; other site 592022005358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022005359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022005360 active site 592022005361 phosphorylation site [posttranslational modification] 592022005362 intermolecular recognition site; other site 592022005363 dimerization interface [polypeptide binding]; other site 592022005364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022005365 DNA binding site [nucleotide binding] 592022005366 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 592022005367 putative homodimer interface [polypeptide binding]; other site 592022005368 putative homotetramer interface [polypeptide binding]; other site 592022005369 allosteric switch controlling residues; other site 592022005370 putative metal binding site [ion binding]; other site 592022005371 putative homodimer-homodimer interface [polypeptide binding]; other site 592022005372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592022005373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592022005374 metal-binding site [ion binding] 592022005375 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592022005376 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592022005377 metal-binding site [ion binding] 592022005378 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592022005379 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592022005380 metal-binding site [ion binding] 592022005381 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592022005382 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592022005383 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 592022005384 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 592022005385 D-galactonate transporter; Region: 2A0114; TIGR00893 592022005386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005387 putative substrate translocation pore; other site 592022005388 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 592022005389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592022005390 catalytic loop [active] 592022005391 iron binding site [ion binding]; other site 592022005392 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022005393 YibE/F-like protein; Region: YibE_F; pfam07907 592022005394 YibE/F-like protein; Region: YibE_F; pfam07907 592022005395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022005396 dimerization interface [polypeptide binding]; other site 592022005397 putative DNA binding site [nucleotide binding]; other site 592022005398 putative Zn2+ binding site [ion binding]; other site 592022005399 arsenical pump membrane protein; Provisional; Region: PRK15445 592022005400 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 592022005401 transmembrane helices; other site 592022005402 DNA topoisomerase III; Provisional; Region: PRK07726 592022005403 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 592022005404 active site 592022005405 putative interdomain interaction site [polypeptide binding]; other site 592022005406 putative metal-binding site [ion binding]; other site 592022005407 putative nucleotide binding site [chemical binding]; other site 592022005408 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592022005409 domain I; other site 592022005410 DNA binding groove [nucleotide binding] 592022005411 phosphate binding site [ion binding]; other site 592022005412 domain II; other site 592022005413 domain III; other site 592022005414 nucleotide binding site [chemical binding]; other site 592022005415 catalytic site [active] 592022005416 domain IV; other site 592022005417 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 592022005418 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 592022005419 CoenzymeA binding site [chemical binding]; other site 592022005420 subunit interaction site [polypeptide binding]; other site 592022005421 PHB binding site; other site 592022005422 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 592022005423 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 592022005424 nudix motif; other site 592022005425 Predicted membrane protein [Function unknown]; Region: COG2323 592022005426 Tannase and feruloyl esterase; Region: Tannase; pfam07519 592022005427 Predicted permeases [General function prediction only]; Region: COG0679 592022005428 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 592022005429 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 592022005430 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 592022005431 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592022005432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022005433 DNA-binding site [nucleotide binding]; DNA binding site 592022005434 FCD domain; Region: FCD; pfam07729 592022005435 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 592022005436 tartrate dehydrogenase; Provisional; Region: PRK08194 592022005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022005439 putative substrate translocation pore; other site 592022005440 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592022005441 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022005442 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 592022005443 dimerization interface [polypeptide binding]; other site 592022005444 active site 592022005445 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 592022005446 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 592022005447 catalytic motif [active] 592022005448 Zn binding site [ion binding]; other site 592022005449 RibD C-terminal domain; Region: RibD_C; cl17279 592022005450 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022005451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022005452 non-specific DNA binding site [nucleotide binding]; other site 592022005453 salt bridge; other site 592022005454 sequence-specific DNA binding site [nucleotide binding]; other site 592022005455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022005456 binding surface 592022005457 TPR motif; other site 592022005458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592022005459 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 592022005460 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592022005461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022005462 S-adenosylmethionine binding site [chemical binding]; other site 592022005463 Mor transcription activator family; Region: Mor; cl02360 592022005464 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 592022005465 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 592022005466 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 592022005467 active site residue [active] 592022005468 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 592022005469 active site residue [active] 592022005470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022005471 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022005472 active site 592022005473 motif I; other site 592022005474 motif II; other site 592022005475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022005476 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 592022005477 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022005478 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022005479 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 592022005480 NodB motif; other site 592022005481 active site 592022005482 catalytic site [active] 592022005483 metal binding site [ion binding]; metal-binding site 592022005484 Homoserine O-succinyltransferase; Region: HTS; pfam04204 592022005485 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 592022005486 proposed active site lysine [active] 592022005487 conserved cys residue [active] 592022005488 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 592022005489 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 592022005490 Potassium binding sites [ion binding]; other site 592022005491 Cesium cation binding sites [ion binding]; other site 592022005492 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 592022005493 catalytic residues [active] 592022005494 dimer interface [polypeptide binding]; other site 592022005495 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 592022005496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 592022005497 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592022005498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022005499 Walker A/P-loop; other site 592022005500 ATP binding site [chemical binding]; other site 592022005501 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022005502 ABC transporter signature motif; other site 592022005503 Walker B; other site 592022005504 D-loop; other site 592022005505 ABC transporter; Region: ABC_tran_2; pfam12848 592022005506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022005507 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 592022005508 Virulence factor; Region: Virulence_fact; pfam13769 592022005509 HEAT repeats; Region: HEAT_2; pfam13646 592022005510 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 592022005511 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 592022005512 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 592022005513 NodB motif; other site 592022005514 active site 592022005515 catalytic site [active] 592022005516 Zn binding site [ion binding]; other site 592022005517 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 592022005518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022005519 YpjP-like protein; Region: YpjP; pfam14005 592022005520 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592022005521 catalytic residues [active] 592022005522 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 592022005523 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 592022005524 putative binding site residues; other site 592022005525 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 592022005526 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 592022005527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022005528 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 592022005529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022005530 homodimer interface [polypeptide binding]; other site 592022005531 catalytic residue [active] 592022005532 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 592022005533 cobalamin synthase; Reviewed; Region: cobS; PRK00235 592022005534 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592022005535 catalytic core [active] 592022005536 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 592022005537 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 592022005538 Predicted permeases [General function prediction only]; Region: RarD; COG2962 592022005539 EamA-like transporter family; Region: EamA; pfam00892 592022005540 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 592022005541 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022005542 DNA binding residues [nucleotide binding] 592022005543 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 592022005544 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 592022005545 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 592022005546 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 592022005547 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592022005548 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592022005549 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 592022005550 GIY-YIG motif/motif A; other site 592022005551 active site 592022005552 catalytic site [active] 592022005553 metal binding site [ion binding]; metal-binding site 592022005554 5'-3' exonuclease; Region: 53EXOc; smart00475 592022005555 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 592022005556 active site 592022005557 metal binding site 1 [ion binding]; metal-binding site 592022005558 putative 5' ssDNA interaction site; other site 592022005559 metal binding site 3; metal-binding site 592022005560 metal binding site 2 [ion binding]; metal-binding site 592022005561 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 592022005562 putative DNA binding site [nucleotide binding]; other site 592022005563 putative metal binding site [ion binding]; other site 592022005564 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 592022005565 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 592022005566 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 592022005567 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 592022005568 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 592022005569 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 592022005570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022005571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022005572 DNA binding residues [nucleotide binding] 592022005573 Putative zinc-finger; Region: zf-HC2; pfam13490 592022005574 Anti-sigma-K factor rskA; Region: RskA; pfam10099 592022005575 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592022005576 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 592022005577 putative dimer interface [polypeptide binding]; other site 592022005578 Replication terminator protein; Region: RTP; pfam02334 592022005579 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 592022005580 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 592022005581 multidrug efflux protein; Reviewed; Region: PRK01766 592022005582 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 592022005583 cation binding site [ion binding]; other site 592022005584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022005585 classical (c) SDRs; Region: SDR_c; cd05233 592022005586 NAD(P) binding site [chemical binding]; other site 592022005587 active site 592022005588 phytoene desaturase; Region: crtI_fam; TIGR02734 592022005589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022005590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022005591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022005592 active site 592022005593 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 592022005594 Sulfatase; Region: Sulfatase; pfam00884 592022005595 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 592022005596 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 592022005597 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022005598 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 592022005599 NodB motif; other site 592022005600 active site 592022005601 catalytic site [active] 592022005602 metal binding site [ion binding]; metal-binding site 592022005603 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 592022005604 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 592022005605 TrkA-C domain; Region: TrkA_C; pfam02080 592022005606 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592022005607 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 592022005608 PA/protease domain interface [polypeptide binding]; other site 592022005609 putative integrin binding motif; other site 592022005610 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 592022005611 Peptidase family M28; Region: Peptidase_M28; pfam04389 592022005612 metal binding site [ion binding]; metal-binding site 592022005613 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022005614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022005615 dimer interface [polypeptide binding]; other site 592022005616 phosphorylation site [posttranslational modification] 592022005617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022005618 ATP binding site [chemical binding]; other site 592022005619 Mg2+ binding site [ion binding]; other site 592022005620 G-X-G motif; other site 592022005621 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 592022005622 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022005623 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 592022005624 carbohydrate binding site [chemical binding]; other site 592022005625 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 592022005626 carbohydrate binding site [chemical binding]; other site 592022005627 pullulanase, type I; Region: pulA_typeI; TIGR02104 592022005628 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 592022005629 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 592022005630 Ca binding site [ion binding]; other site 592022005631 active site 592022005632 catalytic site [active] 592022005633 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 592022005634 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022005635 NAD(P) binding site [chemical binding]; other site 592022005636 catalytic residues [active] 592022005637 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592022005638 Cytochrome P450; Region: p450; cl12078 592022005639 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 592022005640 active site 592022005641 ATP binding site [chemical binding]; other site 592022005642 substrate binding site [chemical binding]; other site 592022005643 flagellar motor protein MotA; Validated; Region: PRK08124 592022005644 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 592022005645 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 592022005646 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 592022005647 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 592022005648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592022005649 ligand binding site [chemical binding]; other site 592022005650 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 592022005651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022005652 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 592022005653 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 592022005654 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 592022005655 SelR domain; Region: SelR; pfam01641 592022005656 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 592022005657 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592022005658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022005659 DNA-binding site [nucleotide binding]; DNA binding site 592022005660 FCD domain; Region: FCD; pfam07729 592022005661 S-methylmethionine transporter; Provisional; Region: PRK11387 592022005662 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 592022005663 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 592022005664 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592022005665 SurA N-terminal domain; Region: SurA_N; pfam09312 592022005666 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592022005667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022005668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022005669 active site 592022005670 phosphorylation site [posttranslational modification] 592022005671 intermolecular recognition site; other site 592022005672 dimerization interface [polypeptide binding]; other site 592022005673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022005674 DNA binding site [nucleotide binding] 592022005675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022005676 dimer interface [polypeptide binding]; other site 592022005677 phosphorylation site [posttranslational modification] 592022005678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 592022005679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022005680 ATP binding site [chemical binding]; other site 592022005681 Mg2+ binding site [ion binding]; other site 592022005682 G-X-G motif; other site 592022005683 allantoinase; Provisional; Region: PRK06189 592022005684 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 592022005685 active site 592022005686 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 592022005687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005688 putative substrate translocation pore; other site 592022005689 POT family; Region: PTR2; pfam00854 592022005690 malate dehydrogenase; Provisional; Region: PRK13529 592022005691 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592022005692 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 592022005693 NAD(P) binding site [chemical binding]; other site 592022005694 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 592022005695 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022005696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022005697 motif II; other site 592022005698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022005699 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 592022005700 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 592022005701 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 592022005702 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022005703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 592022005704 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 592022005705 catalytic residues [active] 592022005706 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592022005707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022005708 substrate binding pocket [chemical binding]; other site 592022005709 membrane-bound complex binding site; other site 592022005710 hinge residues; other site 592022005711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022005712 dimer interface [polypeptide binding]; other site 592022005713 conserved gate region; other site 592022005714 putative PBP binding loops; other site 592022005715 ABC-ATPase subunit interface; other site 592022005716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022005717 dimer interface [polypeptide binding]; other site 592022005718 conserved gate region; other site 592022005719 putative PBP binding loops; other site 592022005720 ABC-ATPase subunit interface; other site 592022005721 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592022005722 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592022005723 Walker A/P-loop; other site 592022005724 ATP binding site [chemical binding]; other site 592022005725 Q-loop/lid; other site 592022005726 ABC transporter signature motif; other site 592022005727 Walker B; other site 592022005728 D-loop; other site 592022005729 H-loop/switch region; other site 592022005730 Riboflavin kinase; Region: Flavokinase; pfam01687 592022005731 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592022005732 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592022005733 active site 592022005734 non-prolyl cis peptide bond; other site 592022005735 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022005736 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022005737 active site 592022005738 metal binding site [ion binding]; metal-binding site 592022005739 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 592022005740 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 592022005741 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 592022005742 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 592022005743 amidase catalytic site [active] 592022005744 Zn binding residues [ion binding]; other site 592022005745 substrate binding site [chemical binding]; other site 592022005746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022005747 Coenzyme A binding pocket [chemical binding]; other site 592022005748 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022005749 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 592022005750 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592022005751 Cytochrome P450; Region: p450; cl12078 592022005752 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 592022005753 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 592022005754 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 592022005755 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592022005756 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 592022005757 NAD(P) binding pocket [chemical binding]; other site 592022005758 Uncharacterized conserved protein [Function unknown]; Region: COG3402 592022005759 Predicted membrane protein [Function unknown]; Region: COG3428 592022005760 Bacterial PH domain; Region: DUF304; pfam03703 592022005761 Bacterial PH domain; Region: DUF304; pfam03703 592022005762 Bacterial PH domain; Region: DUF304; cl01348 592022005763 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 592022005764 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 592022005765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022005766 catalytic residue [active] 592022005767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022005768 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 592022005769 putative substrate binding site [chemical binding]; other site 592022005770 putative ATP binding site [chemical binding]; other site 592022005771 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 592022005772 UbiA prenyltransferase family; Region: UbiA; pfam01040 592022005773 Protein of unknown function (DUF867); Region: DUF867; pfam05908 592022005774 Methyltransferase domain; Region: Methyltransf_32; pfam13679 592022005775 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592022005776 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022005777 DNA binding residues [nucleotide binding] 592022005778 Small acid-soluble spore protein H family; Region: SspH; pfam08141 592022005779 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 592022005780 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 592022005781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022005782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022005783 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 592022005784 putative dimerization interface [polypeptide binding]; other site 592022005785 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 592022005786 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 592022005787 active site 592022005788 dimer interface [polypeptide binding]; other site 592022005789 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 592022005790 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 592022005791 active site 592022005792 FMN binding site [chemical binding]; other site 592022005793 substrate binding site [chemical binding]; other site 592022005794 3Fe-4S cluster binding site [ion binding]; other site 592022005795 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 592022005796 domain interface; other site 592022005797 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 592022005798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022005799 Staygreen protein; Region: Staygreen; pfam12638 592022005800 Tannase and feruloyl esterase; Region: Tannase; pfam07519 592022005801 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 592022005802 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 592022005803 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 592022005804 homodimer interface [polypeptide binding]; other site 592022005805 NADP binding site [chemical binding]; other site 592022005806 substrate binding site [chemical binding]; other site 592022005807 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 592022005808 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 592022005809 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 592022005810 PLD-like domain; Region: PLDc_2; pfam13091 592022005811 putative active site [active] 592022005812 catalytic site [active] 592022005813 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 592022005814 putative active site [active] 592022005815 catalytic site [active] 592022005816 Predicted acetyltransferase [General function prediction only]; Region: COG3981 592022005817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022005818 Coenzyme A binding pocket [chemical binding]; other site 592022005819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022005820 MarR family; Region: MarR; pfam01047 592022005821 LrgA family; Region: LrgA; cl00608 592022005822 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 592022005823 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022005824 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022005825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022005826 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 592022005827 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 592022005828 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 592022005829 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 592022005830 Ligand binding site; other site 592022005831 Putative Catalytic site; other site 592022005832 DXD motif; other site 592022005833 Predicted membrane protein [Function unknown]; Region: COG2246 592022005834 GtrA-like protein; Region: GtrA; pfam04138 592022005835 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592022005836 active site 592022005837 tetramer interface; other site 592022005838 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022005839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022005840 active site 592022005841 phosphorylation site [posttranslational modification] 592022005842 intermolecular recognition site; other site 592022005843 dimerization interface [polypeptide binding]; other site 592022005844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022005845 DNA binding site [nucleotide binding] 592022005846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022005847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022005848 dimerization interface [polypeptide binding]; other site 592022005849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022005850 dimer interface [polypeptide binding]; other site 592022005851 phosphorylation site [posttranslational modification] 592022005852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022005853 ATP binding site [chemical binding]; other site 592022005854 Mg2+ binding site [ion binding]; other site 592022005855 G-X-G motif; other site 592022005856 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 592022005857 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 592022005858 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592022005859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022005860 substrate binding pocket [chemical binding]; other site 592022005861 membrane-bound complex binding site; other site 592022005862 hinge residues; other site 592022005863 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592022005864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022005865 dimer interface [polypeptide binding]; other site 592022005866 conserved gate region; other site 592022005867 putative PBP binding loops; other site 592022005868 ABC-ATPase subunit interface; other site 592022005869 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592022005870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022005871 dimer interface [polypeptide binding]; other site 592022005872 conserved gate region; other site 592022005873 putative PBP binding loops; other site 592022005874 ABC-ATPase subunit interface; other site 592022005875 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 592022005876 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 592022005877 Walker A/P-loop; other site 592022005878 ATP binding site [chemical binding]; other site 592022005879 Q-loop/lid; other site 592022005880 ABC transporter signature motif; other site 592022005881 Walker B; other site 592022005882 D-loop; other site 592022005883 H-loop/switch region; other site 592022005884 TOBE-like domain; Region: TOBE_3; pfam12857 592022005885 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 592022005886 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592022005887 dimer interface [polypeptide binding]; other site 592022005888 active site 592022005889 CoA binding pocket [chemical binding]; other site 592022005890 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022005891 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022005892 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022005893 YolD-like protein; Region: YolD; pfam08863 592022005894 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592022005895 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592022005896 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592022005897 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 592022005898 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 592022005899 putative substrate binding site [chemical binding]; other site 592022005900 putative ATP binding site [chemical binding]; other site 592022005901 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 592022005902 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592022005903 active site 592022005904 phosphorylation site [posttranslational modification] 592022005905 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 592022005906 active site 592022005907 P-loop; other site 592022005908 phosphorylation site [posttranslational modification] 592022005909 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 592022005910 aspartate kinase; Reviewed; Region: PRK09034 592022005911 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 592022005912 putative catalytic residues [active] 592022005913 putative nucleotide binding site [chemical binding]; other site 592022005914 putative aspartate binding site [chemical binding]; other site 592022005915 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 592022005916 allosteric regulatory residue; other site 592022005917 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 592022005918 YusW-like protein; Region: YusW; pfam14039 592022005919 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 592022005920 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 592022005921 E-class dimer interface [polypeptide binding]; other site 592022005922 P-class dimer interface [polypeptide binding]; other site 592022005923 active site 592022005924 Cu2+ binding site [ion binding]; other site 592022005925 Zn2+ binding site [ion binding]; other site 592022005926 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 592022005927 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022005928 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592022005929 DNA binding residues [nucleotide binding] 592022005930 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 592022005931 classical (c) SDRs; Region: SDR_c; cd05233 592022005932 NAD(P) binding site [chemical binding]; other site 592022005933 active site 592022005934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022005935 dimerization interface [polypeptide binding]; other site 592022005936 putative DNA binding site [nucleotide binding]; other site 592022005937 putative Zn2+ binding site [ion binding]; other site 592022005938 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 592022005939 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 592022005940 NAD(P) binding site [chemical binding]; other site 592022005941 catalytic residues [active] 592022005942 Putative transcription activator [Transcription]; Region: TenA; COG0819 592022005943 TspO/MBR family; Region: TspO_MBR; cl01379 592022005944 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 592022005945 Na2 binding site [ion binding]; other site 592022005946 putative substrate binding site 1 [chemical binding]; other site 592022005947 Na binding site 1 [ion binding]; other site 592022005948 putative substrate binding site 2 [chemical binding]; other site 592022005949 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022005950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022005951 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022005952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022005953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022005954 DNA binding site [nucleotide binding] 592022005955 domain linker motif; other site 592022005956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592022005957 dimerization interface [polypeptide binding]; other site 592022005958 ligand binding site [chemical binding]; other site 592022005959 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 592022005960 conserved cys residue [active] 592022005961 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022005962 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022005963 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022005964 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022005965 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022005966 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022005967 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022005968 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592022005969 DNA interaction; other site 592022005970 Metal-binding active site; metal-binding site 592022005971 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592022005972 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 592022005973 active site 592022005974 DNA binding site [nucleotide binding] 592022005975 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 592022005976 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592022005977 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022005978 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592022005979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022005980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022005981 Coenzyme A binding pocket [chemical binding]; other site 592022005982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022005983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022005984 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 592022005985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022005986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022005987 putative substrate translocation pore; other site 592022005988 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 592022005989 substrate binding site [chemical binding]; other site 592022005990 multimerization interface [polypeptide binding]; other site 592022005991 ATP binding site [chemical binding]; other site 592022005992 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 592022005993 thiamine phosphate binding site [chemical binding]; other site 592022005994 active site 592022005995 pyrophosphate binding site [ion binding]; other site 592022005996 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 592022005997 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 592022005998 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022005999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022006000 non-specific DNA binding site [nucleotide binding]; other site 592022006001 salt bridge; other site 592022006002 sequence-specific DNA binding site [nucleotide binding]; other site 592022006003 Putative zinc-finger; Region: zf-HC2; pfam13490 592022006004 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 592022006005 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 592022006006 RNA polymerase sigma factor; Provisional; Region: PRK12541 592022006007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022006008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022006009 DNA binding residues [nucleotide binding] 592022006010 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 592022006011 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 592022006012 MoxR-like ATPases [General function prediction only]; Region: COG0714 592022006013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022006014 Walker A motif; other site 592022006015 Walker A motif; other site 592022006016 ATP binding site [chemical binding]; other site 592022006017 Walker B motif; other site 592022006018 arginine finger; other site 592022006019 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 592022006020 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 592022006021 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 592022006022 metal ion-dependent adhesion site (MIDAS); other site 592022006023 EamA-like transporter family; Region: EamA; pfam00892 592022006024 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022006025 EamA-like transporter family; Region: EamA; pfam00892 592022006026 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 592022006027 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 592022006028 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 592022006029 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 592022006030 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 592022006031 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592022006032 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022006033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022006034 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 592022006035 active site 592022006036 putative substrate binding region [chemical binding]; other site 592022006037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022006038 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022006039 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 592022006040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022006041 Walker A/P-loop; other site 592022006042 ATP binding site [chemical binding]; other site 592022006043 Q-loop/lid; other site 592022006044 ABC transporter signature motif; other site 592022006045 Walker B; other site 592022006046 D-loop; other site 592022006047 H-loop/switch region; other site 592022006048 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022006049 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022006050 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 592022006051 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 592022006052 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 592022006053 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 592022006054 active site 592022006055 putative carbohydrate kinase; Provisional; Region: PRK10565 592022006056 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 592022006057 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 592022006058 putative substrate binding site [chemical binding]; other site 592022006059 putative ATP binding site [chemical binding]; other site 592022006060 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 592022006061 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592022006062 hypothetical protein; Provisional; Region: PRK10621 592022006063 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592022006064 Predicted transcriptional regulators [Transcription]; Region: COG1378 592022006065 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 592022006066 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 592022006067 C-terminal domain interface [polypeptide binding]; other site 592022006068 sugar binding site [chemical binding]; other site 592022006069 azoreductase; Reviewed; Region: PRK00170 592022006070 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022006071 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 592022006072 classical (c) SDRs; Region: SDR_c; cd05233 592022006073 NAD(P) binding site [chemical binding]; other site 592022006074 active site 592022006075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592022006076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022006077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022006078 active site 592022006079 phosphorylation site [posttranslational modification] 592022006080 intermolecular recognition site; other site 592022006081 dimerization interface [polypeptide binding]; other site 592022006082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022006083 DNA binding site [nucleotide binding] 592022006084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022006085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022006086 dimerization interface [polypeptide binding]; other site 592022006087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022006088 dimer interface [polypeptide binding]; other site 592022006089 phosphorylation site [posttranslational modification] 592022006090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006091 ATP binding site [chemical binding]; other site 592022006092 Mg2+ binding site [ion binding]; other site 592022006093 G-X-G motif; other site 592022006094 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022006095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022006096 DNA-binding site [nucleotide binding]; DNA binding site 592022006097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022006098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022006099 homodimer interface [polypeptide binding]; other site 592022006100 catalytic residue [active] 592022006101 Lysine efflux permease [General function prediction only]; Region: COG1279 592022006102 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 592022006103 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592022006104 active site 592022006105 metal binding site [ion binding]; metal-binding site 592022006106 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022006107 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 592022006108 Anti-repressor SinI; Region: SinI; pfam08671 592022006109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022006110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022006111 non-specific DNA binding site [nucleotide binding]; other site 592022006112 salt bridge; other site 592022006113 sequence-specific DNA binding site [nucleotide binding]; other site 592022006114 Anti-repressor SinI; Region: SinI; pfam08671 592022006115 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 592022006116 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592022006117 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 592022006118 nudix motif; other site 592022006119 Isochorismatase family; Region: Isochorismatase; pfam00857 592022006120 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592022006121 catalytic triad [active] 592022006122 conserved cis-peptide bond; other site 592022006123 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 592022006124 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 592022006125 active site 592022006126 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 592022006127 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 592022006128 active site 592022006129 (T/H)XGH motif; other site 592022006130 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 592022006131 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 592022006132 homodimer interface [polypeptide binding]; other site 592022006133 NAD binding pocket [chemical binding]; other site 592022006134 ATP binding pocket [chemical binding]; other site 592022006135 Mg binding site [ion binding]; other site 592022006136 active-site loop [active] 592022006137 hypothetical protein; Provisional; Region: PRK08582 592022006138 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 592022006139 RNA binding site [nucleotide binding]; other site 592022006140 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 592022006141 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 592022006142 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 592022006143 putative active site [active] 592022006144 catalytic triad [active] 592022006145 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 592022006146 PA/protease domain interface [polypeptide binding]; other site 592022006147 putative integrin binding motif; other site 592022006148 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 592022006149 catalytic residues [active] 592022006150 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 592022006151 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 592022006152 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 592022006153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022006154 NAD(P) binding site [chemical binding]; other site 592022006155 active site 592022006156 Acylphosphatase; Region: Acylphosphatase; pfam00708 592022006157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022006159 putative substrate translocation pore; other site 592022006160 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 592022006161 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592022006162 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592022006163 Cupin domain; Region: Cupin_2; cl17218 592022006164 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022006165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022006166 EamA-like transporter family; Region: EamA; pfam00892 592022006167 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022006168 EamA-like transporter family; Region: EamA; pfam00892 592022006169 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 592022006170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022006171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022006172 ABC transporter; Region: ABC_tran_2; pfam12848 592022006173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022006174 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 592022006175 Spore germination protein; Region: Spore_permease; pfam03845 592022006176 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022006177 spore germination protein B3, frameshift 592022006178 YtoQ family protein; Region: YtoQ_fam; TIGR03646 592022006179 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022006180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022006181 Walker A/P-loop; other site 592022006182 ATP binding site [chemical binding]; other site 592022006183 Q-loop/lid; other site 592022006184 ABC transporter signature motif; other site 592022006185 Walker B; other site 592022006186 D-loop; other site 592022006187 H-loop/switch region; other site 592022006188 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022006189 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592022006190 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 592022006191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022006192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022006193 DNA binding site [nucleotide binding] 592022006194 domain linker motif; other site 592022006195 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 592022006196 putative dimerization interface [polypeptide binding]; other site 592022006197 putative ligand binding site [chemical binding]; other site 592022006198 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 592022006199 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 592022006200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022006201 FeS/SAM binding site; other site 592022006202 potential frameshift: common BLAST hit: gi|251800152|ref|YP_003014883.1| membrane protein-like protein 592022006203 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 592022006204 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 592022006205 DNA topoisomerase III; Provisional; Region: PRK07726 592022006206 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 592022006207 active site 592022006208 putative interdomain interaction site [polypeptide binding]; other site 592022006209 putative metal-binding site [ion binding]; other site 592022006210 putative nucleotide binding site [chemical binding]; other site 592022006211 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592022006212 domain I; other site 592022006213 DNA binding groove [nucleotide binding] 592022006214 phosphate binding site [ion binding]; other site 592022006215 domain II; other site 592022006216 domain III; other site 592022006217 nucleotide binding site [chemical binding]; other site 592022006218 catalytic site [active] 592022006219 domain IV; other site 592022006220 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 592022006221 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 592022006222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022006223 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592022006224 spore germination protein, frameshift 592022006225 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 592022006226 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592022006227 NAD binding site [chemical binding]; other site 592022006228 catalytic Zn binding site [ion binding]; other site 592022006229 structural Zn binding site [ion binding]; other site 592022006230 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 592022006231 putative active site [active] 592022006232 catalytic site [active] 592022006233 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 592022006234 PLD-like domain; Region: PLDc_2; pfam13091 592022006235 putative active site [active] 592022006236 catalytic site [active] 592022006237 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 592022006238 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022006239 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022006240 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 592022006241 VanW like protein; Region: VanW; pfam04294 592022006242 Predicted membrane protein [Function unknown]; Region: COG1289 592022006243 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592022006244 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022006245 Heat induced stress protein YflT; Region: YflT; pfam11181 592022006246 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 592022006247 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 592022006248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022006249 ATP binding site [chemical binding]; other site 592022006250 putative Mg++ binding site [ion binding]; other site 592022006251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022006252 nucleotide binding region [chemical binding]; other site 592022006253 ATP-binding site [chemical binding]; other site 592022006254 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 592022006255 HRDC domain; Region: HRDC; pfam00570 592022006256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022006257 PAS domain; Region: PAS_9; pfam13426 592022006258 putative active site [active] 592022006259 heme pocket [chemical binding]; other site 592022006260 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 592022006261 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592022006262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022006263 Walker A motif; other site 592022006264 ATP binding site [chemical binding]; other site 592022006265 Walker B motif; other site 592022006266 arginine finger; other site 592022006267 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 592022006268 agmatinase; Region: agmatinase; TIGR01230 592022006269 oligomer interface [polypeptide binding]; other site 592022006270 putative active site [active] 592022006271 Mn binding site [ion binding]; other site 592022006272 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022006273 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 592022006274 NAD(P) binding site [chemical binding]; other site 592022006275 catalytic residues [active] 592022006276 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 592022006277 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 592022006278 Na binding site [ion binding]; other site 592022006279 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592022006280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022006281 ATP binding site [chemical binding]; other site 592022006282 putative Mg++ binding site [ion binding]; other site 592022006283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022006284 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 592022006285 nucleotide binding region [chemical binding]; other site 592022006286 ATP-binding site [chemical binding]; other site 592022006287 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 592022006288 UbiA prenyltransferase family; Region: UbiA; pfam01040 592022006289 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 592022006290 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 592022006291 Predicted membrane protein [Function unknown]; Region: COG1511 592022006292 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022006293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006294 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 592022006295 pentamer interface [polypeptide binding]; other site 592022006296 dodecaamer interface [polypeptide binding]; other site 592022006297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006298 putative substrate translocation pore; other site 592022006299 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592022006300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022006301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022006302 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 592022006303 putative dimerization interface [polypeptide binding]; other site 592022006304 Predicted transcriptional regulators [Transcription]; Region: COG1725 592022006305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022006306 DNA-binding site [nucleotide binding]; DNA binding site 592022006307 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022006308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592022006309 Walker A/P-loop; other site 592022006310 ATP binding site [chemical binding]; other site 592022006311 Q-loop/lid; other site 592022006312 ABC transporter signature motif; other site 592022006313 Walker B; other site 592022006314 D-loop; other site 592022006315 H-loop/switch region; other site 592022006316 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592022006317 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022006318 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592022006319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022006320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022006321 DNA binding residues [nucleotide binding] 592022006322 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592022006323 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022006324 DNA polymerase IV; Validated; Region: PRK01810 592022006325 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 592022006326 active site 592022006327 DNA binding site [nucleotide binding] 592022006328 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 592022006329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022006330 MarR family; Region: MarR; pfam01047 592022006331 Cold-inducible protein YdjO; Region: YdjO; pfam14169 592022006332 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592022006333 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 592022006334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006335 Coenzyme A binding pocket [chemical binding]; other site 592022006336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022006337 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022006338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022006339 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022006340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022006341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 592022006342 AAA domain; Region: AAA_11; pfam13086 592022006343 Part of AAA domain; Region: AAA_19; pfam13245 592022006344 AAA domain; Region: AAA_30; pfam13604 592022006345 AAA domain; Region: AAA_12; pfam13087 592022006346 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 592022006347 B12 binding domain; Region: B12-binding_2; pfam02607 592022006348 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 592022006349 B12 binding site [chemical binding]; other site 592022006350 CheB methylesterase; Region: CheB_methylest; pfam01339 592022006351 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 592022006352 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 592022006353 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 592022006354 Protein of unknown function (DUF904); Region: DUF904; pfam06005 592022006355 PAS domain; Region: PAS_10; pfam13596 592022006356 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022006357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022006358 putative active site [active] 592022006359 heme pocket [chemical binding]; other site 592022006360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022006361 dimer interface [polypeptide binding]; other site 592022006362 phosphorylation site [posttranslational modification] 592022006363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006364 ATP binding site [chemical binding]; other site 592022006365 Mg2+ binding site [ion binding]; other site 592022006366 G-X-G motif; other site 592022006367 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 592022006368 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 592022006369 gamma-glutamyl kinase; Provisional; Region: PRK13402 592022006370 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 592022006371 nucleotide binding site [chemical binding]; other site 592022006372 homotetrameric interface [polypeptide binding]; other site 592022006373 putative phosphate binding site [ion binding]; other site 592022006374 putative allosteric binding site; other site 592022006375 PUA domain; Region: PUA; pfam01472 592022006376 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 592022006377 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 592022006378 putative catalytic cysteine [active] 592022006379 Cold-inducible protein YdjO; Region: YdjO; pfam14169 592022006380 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022006381 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 592022006382 dimer interface [polypeptide binding]; other site 592022006383 putative metal binding site [ion binding]; other site 592022006384 hypothetical protein; Validated; Region: PRK06201 592022006385 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 592022006386 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 592022006387 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 592022006388 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 592022006389 Amidinotransferase; Region: Amidinotransf; pfam02274 592022006390 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022006391 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 592022006392 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 592022006393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 592022006394 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 592022006395 substrate binding pocket [chemical binding]; other site 592022006396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592022006397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022006398 non-specific DNA binding site [nucleotide binding]; other site 592022006399 salt bridge; other site 592022006400 sequence-specific DNA binding site [nucleotide binding]; other site 592022006401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592022006402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022006403 binding surface 592022006404 TPR motif; other site 592022006405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592022006406 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 592022006407 oligomeric interface; other site 592022006408 putative active site [active] 592022006409 homodimer interface [polypeptide binding]; other site 592022006410 maltose O-acetyltransferase; Provisional; Region: PRK10092 592022006411 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 592022006412 active site 592022006413 substrate binding site [chemical binding]; other site 592022006414 trimer interface [polypeptide binding]; other site 592022006415 CoA binding site [chemical binding]; other site 592022006416 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 592022006417 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022006418 Zn binding site [ion binding]; other site 592022006419 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 592022006420 Zn binding site [ion binding]; other site 592022006421 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 592022006422 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022006423 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 592022006424 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592022006425 Na binding site [ion binding]; other site 592022006426 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 592022006427 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592022006428 active site 592022006429 catalytic site [active] 592022006430 substrate binding site [chemical binding]; other site 592022006431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 592022006432 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 592022006433 fumarate hydratase; Reviewed; Region: fumC; PRK00485 592022006434 Class II fumarases; Region: Fumarase_classII; cd01362 592022006435 active site 592022006436 tetramer interface [polypeptide binding]; other site 592022006437 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 592022006438 active site 592022006439 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 592022006440 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 592022006441 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022006442 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 592022006443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022006444 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 592022006445 putative active site [active] 592022006446 heme pocket [chemical binding]; other site 592022006447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022006448 putative active site [active] 592022006449 heme pocket [chemical binding]; other site 592022006450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022006451 dimer interface [polypeptide binding]; other site 592022006452 phosphorylation site [posttranslational modification] 592022006453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006454 ATP binding site [chemical binding]; other site 592022006455 Mg2+ binding site [ion binding]; other site 592022006456 G-X-G motif; other site 592022006457 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 592022006458 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 592022006459 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022006460 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 592022006461 active site 592022006462 Zn binding site [ion binding]; other site 592022006463 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 592022006464 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592022006465 active site 592022006466 metal binding site [ion binding]; metal-binding site 592022006467 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 592022006468 active site 592022006469 intersubunit interactions; other site 592022006470 catalytic residue [active] 592022006471 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 592022006472 dimer interface [polypeptide binding]; other site 592022006473 FMN binding site [chemical binding]; other site 592022006474 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 592022006475 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 592022006476 classical (c) SDRs; Region: SDR_c; cd05233 592022006477 NAD(P) binding site [chemical binding]; other site 592022006478 active site 592022006479 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 592022006480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006481 ATP binding site [chemical binding]; other site 592022006482 Mg2+ binding site [ion binding]; other site 592022006483 G-X-G motif; other site 592022006484 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 592022006485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022006486 active site 592022006487 phosphorylation site [posttranslational modification] 592022006488 intermolecular recognition site; other site 592022006489 dimerization interface [polypeptide binding]; other site 592022006490 Transcriptional regulator; Region: CitT; pfam12431 592022006491 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 592022006492 Citrate transporter; Region: CitMHS; pfam03600 592022006493 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592022006494 Citrate transporter; Region: CitMHS; pfam03600 592022006495 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022006496 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 592022006497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022006498 NAD(P) binding site [chemical binding]; other site 592022006499 active site 592022006500 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 592022006501 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 592022006502 metal binding site [ion binding]; metal-binding site 592022006503 dimer interface [polypeptide binding]; other site 592022006504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006505 Coenzyme A binding pocket [chemical binding]; other site 592022006506 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022006507 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592022006508 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 592022006509 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 592022006510 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 592022006511 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 592022006512 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 592022006513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022006514 S-adenosylmethionine binding site [chemical binding]; other site 592022006515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022006516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022006517 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 592022006518 putative dimerization interface [polypeptide binding]; other site 592022006519 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 592022006520 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022006521 diaminopimelate decarboxylase; Region: lysA; TIGR01048 592022006522 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 592022006523 active site 592022006524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592022006525 substrate binding site [chemical binding]; other site 592022006526 catalytic residues [active] 592022006527 dimer interface [polypeptide binding]; other site 592022006528 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592022006529 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592022006530 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 592022006531 PAS domain S-box; Region: sensory_box; TIGR00229 592022006532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022006533 putative active site [active] 592022006534 heme pocket [chemical binding]; other site 592022006535 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022006536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022006537 putative active site [active] 592022006538 heme pocket [chemical binding]; other site 592022006539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022006540 dimer interface [polypeptide binding]; other site 592022006541 phosphorylation site [posttranslational modification] 592022006542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006543 ATP binding site [chemical binding]; other site 592022006544 Mg2+ binding site [ion binding]; other site 592022006545 G-X-G motif; other site 592022006546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022006547 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 592022006548 FAD binding site [chemical binding]; other site 592022006549 substrate binding site [chemical binding]; other site 592022006550 catalytic base [active] 592022006551 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 592022006552 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 592022006553 NADP binding site [chemical binding]; other site 592022006554 homodimer interface [polypeptide binding]; other site 592022006555 active site 592022006556 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 592022006557 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 592022006558 acyl-activating enzyme (AAE) consensus motif; other site 592022006559 putative AMP binding site [chemical binding]; other site 592022006560 putative active site [active] 592022006561 putative CoA binding site [chemical binding]; other site 592022006562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022006563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022006564 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 592022006565 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592022006566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592022006567 enoyl-CoA hydratase; Provisional; Region: PRK06688 592022006568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022006569 substrate binding site [chemical binding]; other site 592022006570 oxyanion hole (OAH) forming residues; other site 592022006571 trimer interface [polypeptide binding]; other site 592022006572 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592022006573 active site 592022006574 Phosphotransferase enzyme family; Region: APH; pfam01636 592022006575 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 592022006576 putative active site [active] 592022006577 putative substrate binding site [chemical binding]; other site 592022006578 ATP binding site [chemical binding]; other site 592022006579 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 592022006580 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 592022006581 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592022006582 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022006583 active site 592022006584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592022006585 classical (c) SDRs; Region: SDR_c; cd05233 592022006586 NAD(P) binding site [chemical binding]; other site 592022006587 active site 592022006588 enoyl-CoA hydratase; Provisional; Region: PRK06688 592022006589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022006590 substrate binding site [chemical binding]; other site 592022006591 oxyanion hole (OAH) forming residues; other site 592022006592 trimer interface [polypeptide binding]; other site 592022006593 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592022006594 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 592022006595 NADP binding site [chemical binding]; other site 592022006596 dimer interface [polypeptide binding]; other site 592022006597 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 592022006598 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 592022006599 active site 592022006600 multimer interface [polypeptide binding]; other site 592022006601 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 592022006602 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 592022006603 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 592022006604 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 592022006605 putative acyltransferase; Provisional; Region: PRK05790 592022006606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592022006607 dimer interface [polypeptide binding]; other site 592022006608 active site 592022006609 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 592022006610 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022006611 inhibitor-cofactor binding pocket; inhibition site 592022006612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022006613 catalytic residue [active] 592022006614 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 592022006615 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022006616 inhibitor-cofactor binding pocket; inhibition site 592022006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022006618 catalytic residue [active] 592022006619 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 592022006620 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022006621 NAD(P) binding site [chemical binding]; other site 592022006622 catalytic residues [active] 592022006623 Uncharacterized conserved protein [Function unknown]; Region: COG5476 592022006624 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 592022006625 MlrC C-terminus; Region: MlrC_C; pfam07171 592022006626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006627 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022006628 Coenzyme A binding pocket [chemical binding]; other site 592022006629 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 592022006630 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022006631 FeS/SAM binding site; other site 592022006632 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 592022006633 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 592022006634 toxin interface [polypeptide binding]; other site 592022006635 Zn binding site [ion binding]; other site 592022006636 lysine transporter; Provisional; Region: PRK10836 592022006637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022006638 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022006639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006640 Coenzyme A binding pocket [chemical binding]; other site 592022006641 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 592022006642 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 592022006643 dimer interface [polypeptide binding]; other site 592022006644 active site 592022006645 metal binding site [ion binding]; metal-binding site 592022006646 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 592022006647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006648 putative substrate translocation pore; other site 592022006649 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592022006650 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 592022006651 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 592022006652 Prephenate dehydratase; Region: PDT; pfam00800 592022006653 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 592022006654 EamA-like transporter family; Region: EamA; pfam00892 592022006655 EamA-like transporter family; Region: EamA; pfam00892 592022006656 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 592022006657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022006658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022006659 homodimer interface [polypeptide binding]; other site 592022006660 catalytic residue [active] 592022006661 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 592022006662 dimer interface [polypeptide binding]; other site 592022006663 [2Fe-2S] cluster binding site [ion binding]; other site 592022006664 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 592022006665 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022006666 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 592022006667 Sulfatase; Region: Sulfatase; pfam00884 592022006668 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 592022006669 active site 592022006670 dimer interface [polypeptide binding]; other site 592022006671 motif 1; other site 592022006672 motif 2; other site 592022006673 motif 3; other site 592022006674 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 592022006675 anticodon binding site; other site 592022006676 amino acid transporter; Region: 2A0306; TIGR00909 592022006677 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 592022006678 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592022006679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006680 putative substrate translocation pore; other site 592022006681 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022006682 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 592022006683 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 592022006684 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 592022006685 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592022006686 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592022006687 Walker A/P-loop; other site 592022006688 ATP binding site [chemical binding]; other site 592022006689 Q-loop/lid; other site 592022006690 ABC transporter signature motif; other site 592022006691 Walker B; other site 592022006692 D-loop; other site 592022006693 H-loop/switch region; other site 592022006694 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 592022006695 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 592022006696 putative active site [active] 592022006697 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 592022006698 dimer interface [polypeptide binding]; other site 592022006699 active site 592022006700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022006701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592022006702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022006703 dimer interface [polypeptide binding]; other site 592022006704 conserved gate region; other site 592022006705 putative PBP binding loops; other site 592022006706 ABC-ATPase subunit interface; other site 592022006707 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592022006708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022006709 dimer interface [polypeptide binding]; other site 592022006710 conserved gate region; other site 592022006711 putative PBP binding loops; other site 592022006712 ABC-ATPase subunit interface; other site 592022006713 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 592022006714 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022006715 substrate binding site [chemical binding]; other site 592022006716 ATP binding site [chemical binding]; other site 592022006717 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 592022006718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022006719 DNA-binding site [nucleotide binding]; DNA binding site 592022006720 UTRA domain; Region: UTRA; pfam07702 592022006721 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022006722 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 592022006723 putative hydrophobic ligand binding site [chemical binding]; other site 592022006724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022006725 dimerization interface [polypeptide binding]; other site 592022006726 putative DNA binding site [nucleotide binding]; other site 592022006727 putative Zn2+ binding site [ion binding]; other site 592022006728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 592022006729 putative hydrolase; Provisional; Region: PRK02113 592022006730 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022006731 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022006732 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 592022006733 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 592022006734 active site residue [active] 592022006735 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 592022006736 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 592022006737 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 592022006738 apolar tunnel; other site 592022006739 heme binding site [chemical binding]; other site 592022006740 dimerization interface [polypeptide binding]; other site 592022006741 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 592022006742 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 592022006743 Protein of unknown function (DUF817); Region: DUF817; pfam05675 592022006744 heat shock protein 90; Provisional; Region: PRK05218 592022006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006746 ATP binding site [chemical binding]; other site 592022006747 Mg2+ binding site [ion binding]; other site 592022006748 G-X-G motif; other site 592022006749 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 592022006750 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 592022006751 putative ligand binding site [chemical binding]; other site 592022006752 putative NAD binding site [chemical binding]; other site 592022006753 putative catalytic site [active] 592022006754 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 592022006755 L-serine binding site [chemical binding]; other site 592022006756 ACT domain interface; other site 592022006757 phage integrase, frameshift 592022006758 Excalibur calcium-binding domain; Region: Excalibur; smart00894 592022006759 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 592022006760 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 592022006761 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 592022006762 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 592022006763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022006764 Zn2+ binding site [ion binding]; other site 592022006765 Mg2+ binding site [ion binding]; other site 592022006766 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 592022006767 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 592022006768 active site 592022006769 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 592022006770 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022006771 EamA-like transporter family; Region: EamA; pfam00892 592022006772 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022006773 EamA-like transporter family; Region: EamA; pfam00892 592022006774 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022006775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022006776 DNA-binding site [nucleotide binding]; DNA binding site 592022006777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022006778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022006779 homodimer interface [polypeptide binding]; other site 592022006780 catalytic residue [active] 592022006781 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 592022006782 ChaB; Region: ChaB; pfam06150 592022006783 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 592022006784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022006785 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 592022006786 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592022006787 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 592022006788 NAD(P) binding site [chemical binding]; other site 592022006789 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 592022006790 putative FMN binding site [chemical binding]; other site 592022006791 DNA polymerase III PolC; Validated; Region: polC; PRK00448 592022006792 transglutaminase; Provisional; Region: tgl; PRK03187 592022006793 DinB superfamily; Region: DinB_2; pfam12867 592022006794 Domain of unknown function (DUF378); Region: DUF378; cl00943 592022006795 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 592022006796 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592022006797 cobalamin binding residues [chemical binding]; other site 592022006798 putative BtuC binding residues; other site 592022006799 dimer interface [polypeptide binding]; other site 592022006800 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 592022006801 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 592022006802 putative active site [active] 592022006803 putative CoA binding site [chemical binding]; other site 592022006804 nudix motif; other site 592022006805 metal binding site [ion binding]; metal-binding site 592022006806 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 592022006807 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592022006808 NAD(P) binding site [chemical binding]; other site 592022006809 putative active site [active] 592022006810 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 592022006811 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592022006812 acyl-activating enzyme (AAE) consensus motif; other site 592022006813 AMP binding site [chemical binding]; other site 592022006814 active site 592022006815 CoA binding site [chemical binding]; other site 592022006816 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022006817 MarR family; Region: MarR; pfam01047 592022006818 VanW like protein; Region: VanW; pfam04294 592022006819 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 592022006820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592022006821 acyl-activating enzyme (AAE) consensus motif; other site 592022006822 AMP binding site [chemical binding]; other site 592022006823 active site 592022006824 CoA binding site [chemical binding]; other site 592022006825 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 592022006826 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 592022006827 active site 592022006828 catalytic site [active] 592022006829 substrate binding site [chemical binding]; other site 592022006830 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592022006831 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 592022006832 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 592022006833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022006834 catalytic residue [active] 592022006835 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 592022006836 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 592022006837 G1 box; other site 592022006838 putative GEF interaction site [polypeptide binding]; other site 592022006839 GTP/Mg2+ binding site [chemical binding]; other site 592022006840 Switch I region; other site 592022006841 G2 box; other site 592022006842 G3 box; other site 592022006843 Switch II region; other site 592022006844 G4 box; other site 592022006845 G5 box; other site 592022006846 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 592022006847 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 592022006848 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 592022006849 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 592022006850 Uncharacterized conserved protein [Function unknown]; Region: COG5609 592022006851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022006852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006853 putative substrate translocation pore; other site 592022006854 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 592022006855 FAD binding domain; Region: FAD_binding_4; pfam01565 592022006856 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 592022006857 Cache domain; Region: Cache_1; pfam02743 592022006858 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 592022006859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022006860 dimerization interface [polypeptide binding]; other site 592022006861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592022006862 dimer interface [polypeptide binding]; other site 592022006863 putative CheW interface [polypeptide binding]; other site 592022006864 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 592022006865 active site 592022006866 metal binding site [ion binding]; metal-binding site 592022006867 homotetramer interface [polypeptide binding]; other site 592022006868 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 592022006869 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592022006870 putative active site [active] 592022006871 putative metal binding site [ion binding]; other site 592022006872 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 592022006873 active site 592022006874 SUMO-1 interface [polypeptide binding]; other site 592022006875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 592022006876 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022006877 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022006878 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 592022006879 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 592022006880 active site 592022006881 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592022006882 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 592022006883 Bacterial transcriptional regulator; Region: IclR; pfam01614 592022006884 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 592022006885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022006886 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592022006887 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592022006888 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 592022006889 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592022006890 carboxyltransferase (CT) interaction site; other site 592022006891 biotinylation site [posttranslational modification]; other site 592022006892 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 592022006893 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 592022006894 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 592022006895 hypothetical protein; Provisional; Region: PRK05463 592022006896 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 592022006897 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 592022006898 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 592022006899 putative active site [active] 592022006900 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 592022006901 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 592022006902 Ca binding site [ion binding]; other site 592022006903 active site 592022006904 catalytic site [active] 592022006905 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 592022006906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022006907 dimerization interface [polypeptide binding]; other site 592022006908 putative DNA binding site [nucleotide binding]; other site 592022006909 putative Zn2+ binding site [ion binding]; other site 592022006910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006911 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022006912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006913 Coenzyme A binding pocket [chemical binding]; other site 592022006914 Isochorismatase family; Region: Isochorismatase; pfam00857 592022006915 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 592022006916 catalytic triad [active] 592022006917 conserved cis-peptide bond; other site 592022006918 DinB family; Region: DinB; cl17821 592022006919 DinB superfamily; Region: DinB_2; pfam12867 592022006920 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022006921 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 592022006922 dimer interface [polypeptide binding]; other site 592022006923 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 592022006924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022006925 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 592022006926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006927 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022006928 Coenzyme A binding pocket [chemical binding]; other site 592022006929 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 592022006930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592022006931 acyl-activating enzyme (AAE) consensus motif; other site 592022006932 AMP binding site [chemical binding]; other site 592022006933 active site 592022006934 CoA binding site [chemical binding]; other site 592022006935 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 592022006936 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 592022006937 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592022006938 dimer interface [polypeptide binding]; other site 592022006939 active site 592022006940 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592022006941 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 592022006942 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 592022006943 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 592022006944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022006945 ATP binding site [chemical binding]; other site 592022006946 putative Mg++ binding site [ion binding]; other site 592022006947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022006948 nucleotide binding region [chemical binding]; other site 592022006949 ATP-binding site [chemical binding]; other site 592022006950 H+ Antiporter protein; Region: 2A0121; TIGR00900 592022006951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022006952 putative substrate translocation pore; other site 592022006953 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022006954 Predicted flavoprotein [General function prediction only]; Region: COG0431 592022006955 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022006956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022006957 active site 592022006958 phosphorylation site [posttranslational modification] 592022006959 intermolecular recognition site; other site 592022006960 dimerization interface [polypeptide binding]; other site 592022006961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022006962 DNA binding residues [nucleotide binding] 592022006963 dimerization interface [polypeptide binding]; other site 592022006964 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592022006965 GAF domain; Region: GAF; pfam01590 592022006966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022006967 Histidine kinase; Region: HisKA_3; pfam07730 592022006968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022006969 ATP binding site [chemical binding]; other site 592022006970 Mg2+ binding site [ion binding]; other site 592022006971 G-X-G motif; other site 592022006972 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022006973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022006974 non-specific DNA binding site [nucleotide binding]; other site 592022006975 salt bridge; other site 592022006976 sequence-specific DNA binding site [nucleotide binding]; other site 592022006977 Cupin domain; Region: Cupin_2; pfam07883 592022006978 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 592022006979 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 592022006980 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 592022006981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 592022006982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022006983 Coenzyme A binding pocket [chemical binding]; other site 592022006984 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 592022006985 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 592022006986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022006987 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 592022006988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 592022006989 DHHA2 domain; Region: DHHA2; pfam02833 592022006990 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 592022006991 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 592022006992 homodimer interface [polypeptide binding]; other site 592022006993 substrate-cofactor binding pocket; other site 592022006994 catalytic residue [active] 592022006995 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592022006996 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 592022006997 putative acyl-acceptor binding pocket; other site 592022006998 xanthine permease; Region: pbuX; TIGR03173 592022006999 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 592022007000 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 592022007001 active site 592022007002 homotetramer interface [polypeptide binding]; other site 592022007003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022007004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007005 Coenzyme A binding pocket [chemical binding]; other site 592022007006 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 592022007007 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 592022007008 manganese transport protein MntH; Reviewed; Region: PRK00701 592022007009 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 592022007010 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 592022007011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022007012 motif II; other site 592022007013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022007014 MarR family; Region: MarR; pfam01047 592022007015 MarR family; Region: MarR_2; cl17246 592022007016 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 592022007017 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 592022007018 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 592022007019 active site 592022007020 catalytic residues [active] 592022007021 DNA binding site [nucleotide binding] 592022007022 Int/Topo IB signature motif; other site 592022007023 ethanolamine permease, frameshift 592022007024 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 592022007025 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 592022007026 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 592022007027 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 592022007028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 592022007029 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 592022007030 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 592022007031 lysine transporter; Provisional; Region: PRK10836 592022007032 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 592022007033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007034 Coenzyme A binding pocket [chemical binding]; other site 592022007035 Isochorismatase family; Region: Isochorismatase; pfam00857 592022007036 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 592022007037 catalytic triad [active] 592022007038 conserved cis-peptide bond; other site 592022007039 Cupin domain; Region: Cupin_2; cl17218 592022007040 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 592022007041 LysE type translocator; Region: LysE; cl00565 592022007042 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022007043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022007044 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 592022007045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 592022007046 CAP-like domain; other site 592022007047 active site 592022007048 primary dimer interface [polypeptide binding]; other site 592022007049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022007050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022007051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592022007052 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 592022007053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022007054 ATP binding site [chemical binding]; other site 592022007055 Mg2+ binding site [ion binding]; other site 592022007056 G-X-G motif; other site 592022007057 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 592022007058 anchoring element; other site 592022007059 dimer interface [polypeptide binding]; other site 592022007060 ATP binding site [chemical binding]; other site 592022007061 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 592022007062 active site 592022007063 putative metal-binding site [ion binding]; other site 592022007064 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592022007065 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 592022007066 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 592022007067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 592022007068 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592022007069 active site 592022007070 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 592022007071 putative active site [active] 592022007072 putative catalytic site [active] 592022007073 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 592022007074 PLD-like domain; Region: PLDc_2; pfam13091 592022007075 putative active site [active] 592022007076 putative catalytic site [active] 592022007077 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 592022007078 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 592022007079 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592022007080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592022007081 catalytic residues [active] 592022007082 aconitate hydratase; Validated; Region: PRK09277 592022007083 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 592022007084 substrate binding site [chemical binding]; other site 592022007085 ligand binding site [chemical binding]; other site 592022007086 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 592022007087 substrate binding site [chemical binding]; other site 592022007088 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 592022007089 Small acid-soluble spore protein P family; Region: SspP; cl12105 592022007090 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592022007091 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 592022007092 putative dimer interface [polypeptide binding]; other site 592022007093 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 592022007094 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 592022007095 DNA binding site [nucleotide binding] 592022007096 heterodimer interface [polypeptide binding]; other site 592022007097 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 592022007098 Protein of unknown function (DUF524); Region: DUF524; pfam04411 592022007099 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 592022007100 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 592022007101 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592022007102 catalytic loop [active] 592022007103 iron binding site [ion binding]; other site 592022007104 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 592022007105 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 592022007106 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 592022007107 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 592022007108 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 592022007109 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 592022007110 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 592022007111 metal-binding site 592022007112 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 592022007113 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 592022007114 XdhC Rossmann domain; Region: XdhC_C; pfam13478 592022007115 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592022007116 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 592022007117 putative dimer interface [polypeptide binding]; other site 592022007118 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022007119 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592022007120 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 592022007121 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 592022007122 hypothetical protein; Provisional; Region: PRK09272 592022007123 MarR family; Region: MarR_2; cl17246 592022007124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022007125 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 592022007126 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 592022007127 Predicted transcriptional regulators [Transcription]; Region: COG1378 592022007128 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 592022007129 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 592022007130 C-terminal domain interface [polypeptide binding]; other site 592022007131 sugar binding site [chemical binding]; other site 592022007132 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592022007133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007134 putative substrate translocation pore; other site 592022007135 Uncharacterized conserved protein [Function unknown]; Region: COG1683 592022007136 Asp23 family; Region: Asp23; pfam03780 592022007137 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 592022007138 Domain of unknown function (DUF202); Region: DUF202; pfam02656 592022007139 drug efflux system protein MdtG; Provisional; Region: PRK09874 592022007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007141 putative substrate translocation pore; other site 592022007142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022007144 putative substrate translocation pore; other site 592022007145 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592022007146 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022007147 DNA binding residues [nucleotide binding] 592022007148 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 592022007149 active site clefts [active] 592022007150 zinc binding site [ion binding]; other site 592022007151 dimer interface [polypeptide binding]; other site 592022007152 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592022007153 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592022007154 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592022007155 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 592022007156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022007157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022007158 active site 592022007159 phosphorylation site [posttranslational modification] 592022007160 intermolecular recognition site; other site 592022007161 dimerization interface [polypeptide binding]; other site 592022007162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022007163 DNA binding site [nucleotide binding] 592022007164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022007165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022007166 dimerization interface [polypeptide binding]; other site 592022007167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022007168 dimer interface [polypeptide binding]; other site 592022007169 phosphorylation site [posttranslational modification] 592022007170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022007171 ATP binding site [chemical binding]; other site 592022007172 Mg2+ binding site [ion binding]; other site 592022007173 G-X-G motif; other site 592022007174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022007175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007176 Coenzyme A binding pocket [chemical binding]; other site 592022007177 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 592022007178 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022007179 RQC domain; Region: RQC; pfam09382 592022007180 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 592022007181 stage II sporulation protein P; Region: spore_II_P; TIGR02867 592022007182 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 592022007183 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 592022007184 putative FMN binding site [chemical binding]; other site 592022007185 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 592022007186 active site 592022007187 SAM binding site [chemical binding]; other site 592022007188 homodimer interface [polypeptide binding]; other site 592022007189 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 592022007190 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 592022007191 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 592022007192 catalytic triad [active] 592022007193 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 592022007194 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 592022007195 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 592022007196 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 592022007197 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 592022007198 active site 592022007199 SAM binding site [chemical binding]; other site 592022007200 homodimer interface [polypeptide binding]; other site 592022007201 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 592022007202 active site 592022007203 SAM binding site [chemical binding]; other site 592022007204 homodimer interface [polypeptide binding]; other site 592022007205 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 592022007206 putative homodimer interface [polypeptide binding]; other site 592022007207 active site 592022007208 SAM binding site [chemical binding]; other site 592022007209 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 592022007210 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 592022007211 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 592022007212 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 592022007213 Precorrin-8X methylmutase; Region: CbiC; pfam02570 592022007214 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 592022007215 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 592022007216 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 592022007217 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 592022007218 putative active site [active] 592022007219 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 592022007220 putative active site [active] 592022007221 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 592022007222 active site 592022007223 SAM binding site [chemical binding]; other site 592022007224 homodimer interface [polypeptide binding]; other site 592022007225 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 592022007226 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 592022007227 dimer interface [polypeptide binding]; other site 592022007228 [2Fe-2S] cluster binding site [ion binding]; other site 592022007229 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 592022007230 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 592022007231 putative oligomer interface [polypeptide binding]; other site 592022007232 putative active site [active] 592022007233 metal binding site [ion binding]; metal-binding site 592022007234 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022007235 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022007236 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 592022007237 A short protein domain of unknown function; Region: IDEAL; smart00914 592022007238 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 592022007239 Uncharacterized conserved protein [Function unknown]; Region: COG2427 592022007240 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 592022007241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022007242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022007243 Membrane transport protein; Region: Mem_trans; cl09117 592022007244 malate dehydrogenase; Provisional; Region: PRK13529 592022007245 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592022007246 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 592022007247 NAD(P) binding site [chemical binding]; other site 592022007248 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592022007249 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 592022007250 putative metal binding site [ion binding]; other site 592022007251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007252 D-galactonate transporter; Region: 2A0114; TIGR00893 592022007253 putative substrate translocation pore; other site 592022007254 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592022007255 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592022007256 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 592022007257 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022007258 UbiD family decarboxylase; Region: TIGR00148 592022007259 aromatic acid decarboxylase; Validated; Region: PRK05920 592022007260 Flavoprotein; Region: Flavoprotein; pfam02441 592022007261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022007262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022007263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022007264 dimerization interface [polypeptide binding]; other site 592022007265 Membrane transport protein; Region: Mem_trans; cl09117 592022007266 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 592022007267 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 592022007268 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 592022007269 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592022007270 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 592022007271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592022007272 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592022007273 Cysteine-rich domain; Region: CCG; pfam02754 592022007274 Cysteine-rich domain; Region: CCG; pfam02754 592022007275 FAD binding domain; Region: FAD_binding_4; pfam01565 592022007276 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 592022007277 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 592022007278 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 592022007279 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022007280 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 592022007281 intracellular protease, PfpI family; Region: PfpI; TIGR01382 592022007282 conserved cys residue [active] 592022007283 IDEAL domain; Region: IDEAL; cl07452 592022007284 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 592022007285 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022007286 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592022007287 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 592022007288 active site 592022007289 NAD binding site [chemical binding]; other site 592022007290 metal binding site [ion binding]; metal-binding site 592022007291 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 592022007292 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 592022007293 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 592022007294 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 592022007295 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 592022007296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022007297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022007298 Walker A/P-loop; other site 592022007299 ATP binding site [chemical binding]; other site 592022007300 Q-loop/lid; other site 592022007301 ABC transporter signature motif; other site 592022007302 Walker B; other site 592022007303 D-loop; other site 592022007304 H-loop/switch region; other site 592022007305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592022007306 Histidine kinase; Region: HisKA_3; pfam07730 592022007307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022007308 ATP binding site [chemical binding]; other site 592022007309 Mg2+ binding site [ion binding]; other site 592022007310 G-X-G motif; other site 592022007311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022007312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022007313 active site 592022007314 phosphorylation site [posttranslational modification] 592022007315 intermolecular recognition site; other site 592022007316 dimerization interface [polypeptide binding]; other site 592022007317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022007318 DNA binding residues [nucleotide binding] 592022007319 dimerization interface [polypeptide binding]; other site 592022007320 N-carbamyl-L-cysteine amidohydrolase, frameshift 592022007321 Predicted integral membrane protein [Function unknown]; Region: COG5542 592022007322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007323 Coenzyme A binding pocket [chemical binding]; other site 592022007324 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 592022007325 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 592022007326 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 592022007327 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 592022007328 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592022007329 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022007330 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 592022007331 Active_site [active] 592022007332 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 592022007333 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 592022007334 active site 592022007335 catalytic site [active] 592022007336 metal binding site [ion binding]; metal-binding site 592022007337 dimer interface [polypeptide binding]; other site 592022007338 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592022007339 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 592022007340 active site 592022007341 catalytic triad [active] 592022007342 dimer interface [polypeptide binding]; other site 592022007343 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592022007344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022007345 Walker A motif; other site 592022007346 ATP binding site [chemical binding]; other site 592022007347 Walker B motif; other site 592022007348 arginine finger; other site 592022007349 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592022007350 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 592022007351 active site 592022007352 catalytic triad [active] 592022007353 dimer interface [polypeptide binding]; other site 592022007354 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022007355 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 592022007356 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 592022007357 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 592022007358 Immunity protein Imm6; Region: Imm6; pfam14434 592022007359 Protein of unknown function, DUF600; Region: DUF600; cl04640 592022007360 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 592022007361 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 592022007362 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 592022007363 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 592022007364 LXG domain of WXG superfamily; Region: LXG; pfam04740 592022007365 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 592022007366 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 592022007367 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 592022007368 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 592022007369 HlyD family secretion protein; Region: HlyD_3; pfam13437 592022007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007371 putative substrate translocation pore; other site 592022007372 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022007373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022007374 MarR family; Region: MarR; pfam01047 592022007375 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 592022007376 active site 592022007377 putative catalytic site [active] 592022007378 DNA binding site [nucleotide binding] 592022007379 putative phosphate binding site [ion binding]; other site 592022007380 metal binding site A [ion binding]; metal-binding site 592022007381 AP binding site [nucleotide binding]; other site 592022007382 metal binding site B [ion binding]; metal-binding site 592022007383 Erythromycin esterase; Region: Erythro_esteras; pfam05139 592022007384 hypothetical protein; Provisional; Region: PRK02487 592022007385 putative oxidoreductase; Provisional; Region: PRK11579 592022007386 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022007387 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022007388 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592022007389 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 592022007390 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592022007391 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 592022007392 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 592022007393 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 592022007394 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 592022007395 putative metal binding site [ion binding]; other site 592022007396 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 592022007397 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 592022007398 putative metal binding site [ion binding]; other site 592022007399 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 592022007400 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 592022007401 putative metal binding site [ion binding]; other site 592022007402 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 592022007403 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 592022007404 active site 592022007405 metal binding site [ion binding]; metal-binding site 592022007406 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 592022007407 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 592022007408 putative active site [active] 592022007409 putative metal binding site [ion binding]; other site 592022007410 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 592022007411 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 592022007412 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592022007413 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022007414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022007415 Walker A/P-loop; other site 592022007416 ATP binding site [chemical binding]; other site 592022007417 Q-loop/lid; other site 592022007418 ABC transporter signature motif; other site 592022007419 Walker B; other site 592022007420 D-loop; other site 592022007421 H-loop/switch region; other site 592022007422 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592022007423 active site 592022007424 catalytic triad [active] 592022007425 oxyanion hole [active] 592022007426 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592022007427 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022007428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022007429 DNA-binding site [nucleotide binding]; DNA binding site 592022007430 RNA-binding motif; other site 592022007431 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022007432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022007433 DNA-binding site [nucleotide binding]; DNA binding site 592022007434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022007435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022007436 homodimer interface [polypeptide binding]; other site 592022007437 catalytic residue [active] 592022007438 pyruvate oxidase; Provisional; Region: PRK08611 592022007439 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 592022007440 PYR/PP interface [polypeptide binding]; other site 592022007441 dimer interface [polypeptide binding]; other site 592022007442 tetramer interface [polypeptide binding]; other site 592022007443 TPP binding site [chemical binding]; other site 592022007444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022007445 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 592022007446 TPP-binding site [chemical binding]; other site 592022007447 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022007448 DNA-binding site [nucleotide binding]; DNA binding site 592022007449 RNA-binding motif; other site 592022007450 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022007451 classical (c) SDRs; Region: SDR_c; cd05233 592022007452 NAD(P) binding site [chemical binding]; other site 592022007453 active site 592022007454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 592022007455 classical (c) SDRs; Region: SDR_c; cd05233 592022007456 NAD(P) binding site [chemical binding]; other site 592022007457 active site 592022007458 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592022007459 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 592022007460 NADP binding site [chemical binding]; other site 592022007461 dimer interface [polypeptide binding]; other site 592022007462 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 592022007463 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 592022007464 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 592022007465 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592022007466 LytTr DNA-binding domain; Region: LytTR; pfam04397 592022007467 Predicted membrane protein [Function unknown]; Region: COG2323 592022007468 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022007469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007470 putative substrate translocation pore; other site 592022007471 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022007472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 592022007473 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 592022007474 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 592022007475 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 592022007476 Cupin; Region: Cupin_1; smart00835 592022007477 peptidase E, frameshift 592022007478 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 592022007479 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 592022007480 HIGH motif; other site 592022007481 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 592022007482 active site 592022007483 KMSKS motif; other site 592022007484 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 592022007485 tRNA binding surface [nucleotide binding]; other site 592022007486 anticodon binding site; other site 592022007487 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592022007488 FAD binding domain; Region: FAD_binding_4; pfam01565 592022007489 Berberine and berberine like; Region: BBE; pfam08031 592022007490 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 592022007491 active site 592022007492 nucleophile elbow; other site 592022007493 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592022007494 active site 592022007495 HIGH motif; other site 592022007496 nucleotide binding site [chemical binding]; other site 592022007497 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 592022007498 GIY-YIG motif/motif A; other site 592022007499 putative active site [active] 592022007500 putative metal binding site [ion binding]; other site 592022007501 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 592022007502 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 592022007503 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592022007504 active site 592022007505 putative transposase or phage integrase, frameshift 592022007506 Phosphotransferase enzyme family; Region: APH; pfam01636 592022007507 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 592022007508 active site 592022007509 substrate binding site [chemical binding]; other site 592022007510 ATP binding site [chemical binding]; other site 592022007511 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 592022007512 malate:quinone oxidoreductase; Validated; Region: PRK05257 592022007513 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 592022007514 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 592022007515 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 592022007516 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 592022007517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592022007518 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022007519 ABC transporter; Region: ABC_tran_2; pfam12848 592022007520 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592022007521 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 592022007522 alpha-galactosidase; Provisional; Region: PRK15076 592022007523 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 592022007524 NAD binding site [chemical binding]; other site 592022007525 sugar binding site [chemical binding]; other site 592022007526 divalent metal binding site [ion binding]; other site 592022007527 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022007528 dimer interface [polypeptide binding]; other site 592022007529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592022007530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022007531 dimer interface [polypeptide binding]; other site 592022007532 conserved gate region; other site 592022007533 putative PBP binding loops; other site 592022007534 ABC-ATPase subunit interface; other site 592022007535 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 592022007536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022007537 dimer interface [polypeptide binding]; other site 592022007538 conserved gate region; other site 592022007539 putative PBP binding loops; other site 592022007540 ABC-ATPase subunit interface; other site 592022007541 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022007542 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592022007543 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022007544 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022007545 DNA binding site [nucleotide binding] 592022007546 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 592022007547 putative dimerization interface [polypeptide binding]; other site 592022007548 putative ligand binding site [chemical binding]; other site 592022007549 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 592022007550 methyltransferase, frameshift 592022007551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007552 Coenzyme A binding pocket [chemical binding]; other site 592022007553 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592022007554 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 592022007555 catalytic site [active] 592022007556 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 592022007557 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 592022007558 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022007559 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 592022007560 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 592022007561 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 592022007562 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022007563 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 592022007564 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592022007565 active site 592022007566 NAD binding site [chemical binding]; other site 592022007567 metal binding site [ion binding]; metal-binding site 592022007568 Protein of unknown function (DUF805); Region: DUF805; pfam05656 592022007569 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022007570 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022007571 Transglycosylase; Region: Transgly; pfam00912 592022007572 Uncharacterized conserved protein [Function unknown]; Region: COG3339 592022007573 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 592022007574 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 592022007575 Cation efflux family; Region: Cation_efflux; cl00316 592022007576 Predicted membrane protein [Function unknown]; Region: COG2323 592022007577 Iron permease FTR1 family; Region: FTR1; cl00475 592022007578 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 592022007579 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 592022007580 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 592022007581 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022007582 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 592022007583 metal binding site [ion binding]; metal-binding site 592022007584 DinB superfamily; Region: DinB_2; pfam12867 592022007585 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 592022007586 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592022007587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022007588 catalytic residue [active] 592022007589 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 592022007590 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 592022007591 trimerization site [polypeptide binding]; other site 592022007592 active site 592022007593 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 592022007594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 592022007595 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 592022007596 acyl-activating enzyme (AAE) consensus motif; other site 592022007597 active site 592022007598 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 592022007599 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 592022007600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022007601 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 592022007602 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022007603 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 592022007604 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 592022007605 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 592022007606 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022007607 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 592022007608 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592022007609 IHF dimer interface [polypeptide binding]; other site 592022007610 IHF - DNA interface [nucleotide binding]; other site 592022007611 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 592022007612 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 592022007613 Spore germination protein; Region: Spore_permease; pfam03845 592022007614 IDEAL domain; Region: IDEAL; pfam08858 592022007615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022007616 S-adenosylmethionine binding site [chemical binding]; other site 592022007617 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022007618 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022007619 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022007620 DNA-binding site [nucleotide binding]; DNA binding site 592022007621 RNA-binding motif; other site 592022007622 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 592022007623 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592022007624 ATP binding site [chemical binding]; other site 592022007625 Mg++ binding site [ion binding]; other site 592022007626 motif III; other site 592022007627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022007628 nucleotide binding region [chemical binding]; other site 592022007629 ATP-binding site [chemical binding]; other site 592022007630 Cold-inducible protein YdjO; Region: YdjO; pfam14169 592022007631 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022007632 RNA-binding motif; other site 592022007633 DNA-binding site [nucleotide binding]; DNA binding site 592022007634 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022007635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022007636 active site 592022007637 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 592022007638 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 592022007639 trimer interface [polypeptide binding]; other site 592022007640 active site 592022007641 substrate binding site [chemical binding]; other site 592022007642 CoA binding site [chemical binding]; other site 592022007643 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 592022007644 DoxX-like family; Region: DoxX_2; pfam13564 592022007645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022007647 putative substrate translocation pore; other site 592022007648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022007649 MarR family; Region: MarR; pfam01047 592022007650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022007651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007652 Coenzyme A binding pocket [chemical binding]; other site 592022007653 DinB superfamily; Region: DinB_2; pfam12867 592022007654 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592022007655 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592022007656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022007657 substrate binding pocket [chemical binding]; other site 592022007658 membrane-bound complex binding site; other site 592022007659 hinge residues; other site 592022007660 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 592022007661 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 592022007662 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 592022007663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007664 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 592022007665 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 592022007666 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592022007667 Nucleoside recognition; Region: Gate; pfam07670 592022007668 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592022007669 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 592022007670 active site 592022007671 catalytic motif [active] 592022007672 Zn binding site [ion binding]; other site 592022007673 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 592022007674 intersubunit interface [polypeptide binding]; other site 592022007675 active site 592022007676 catalytic residue [active] 592022007677 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 592022007678 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592022007679 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592022007680 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 592022007681 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 592022007682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022007683 DNA binding residues [nucleotide binding] 592022007684 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 592022007685 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 592022007686 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592022007687 active site 592022007688 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 592022007689 metal binding site [ion binding]; metal-binding site 592022007690 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 592022007691 active site 592022007692 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 592022007693 hypothetical protein; Validated; Region: PRK07668 592022007694 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022007695 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592022007696 heat shock protein HtpX; Provisional; Region: PRK05457 592022007697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022007698 hypothetical protein; Provisional; Region: PRK02237 592022007699 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592022007700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592022007701 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592022007702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022007703 dimer interface [polypeptide binding]; other site 592022007704 conserved gate region; other site 592022007705 putative PBP binding loops; other site 592022007706 ABC-ATPase subunit interface; other site 592022007707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022007708 dimer interface [polypeptide binding]; other site 592022007709 conserved gate region; other site 592022007710 putative PBP binding loops; other site 592022007711 ABC-ATPase subunit interface; other site 592022007712 short chain dehydrogenase; Provisional; Region: PRK06197 592022007713 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 592022007714 putative NAD(P) binding site [chemical binding]; other site 592022007715 active site 592022007716 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 592022007717 Predicted acetyltransferase [General function prediction only]; Region: COG5628 592022007718 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 592022007719 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 592022007720 putative active site [active] 592022007721 putative metal binding site [ion binding]; other site 592022007722 putative inner membrane protein; Provisional; Region: PRK11099 592022007723 putative inner membrane protein; Provisional; Region: PRK11099 592022007724 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592022007725 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 592022007726 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 592022007727 dimer interface [polypeptide binding]; other site 592022007728 active site 592022007729 metal binding site [ion binding]; metal-binding site 592022007730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022007731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022007732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022007733 dimerization interface [polypeptide binding]; other site 592022007734 EamA-like transporter family; Region: EamA; pfam00892 592022007735 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022007736 EamA-like transporter family; Region: EamA; pfam00892 592022007737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007738 Coenzyme A binding pocket [chemical binding]; other site 592022007739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007740 H+ Antiporter protein; Region: 2A0121; TIGR00900 592022007741 putative substrate translocation pore; other site 592022007742 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022007743 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592022007744 active site 592022007745 metal binding site [ion binding]; metal-binding site 592022007746 topology modulation protein; Reviewed; Region: PRK08118 592022007747 AAA domain; Region: AAA_17; pfam13207 592022007748 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 592022007749 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 592022007750 NADP binding site [chemical binding]; other site 592022007751 homodimer interface [polypeptide binding]; other site 592022007752 active site 592022007753 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592022007754 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 592022007755 NAD(P) binding site [chemical binding]; other site 592022007756 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592022007757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022007758 DNA-binding site [nucleotide binding]; DNA binding site 592022007759 FCD domain; Region: FCD; pfam07729 592022007760 Peptidase family M23; Region: Peptidase_M23; pfam01551 592022007761 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592022007762 catalytic core [active] 592022007763 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 592022007764 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592022007765 Domain of unknown function DUF21; Region: DUF21; pfam01595 592022007766 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592022007767 Transporter associated domain; Region: CorC_HlyC; smart01091 592022007768 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 592022007769 topology modulation protein; Reviewed; Region: PRK08118 592022007770 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592022007771 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022007772 Walker A/P-loop; other site 592022007773 ATP binding site [chemical binding]; other site 592022007774 Q-loop/lid; other site 592022007775 ABC transporter signature motif; other site 592022007776 Walker B; other site 592022007777 D-loop; other site 592022007778 H-loop/switch region; other site 592022007779 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592022007780 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 592022007781 Walker A/P-loop; other site 592022007782 ATP binding site [chemical binding]; other site 592022007783 Q-loop/lid; other site 592022007784 ABC transporter signature motif; other site 592022007785 Walker B; other site 592022007786 D-loop; other site 592022007787 H-loop/switch region; other site 592022007788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592022007789 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592022007790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022007791 dimer interface [polypeptide binding]; other site 592022007792 conserved gate region; other site 592022007793 putative PBP binding loops; other site 592022007794 ABC-ATPase subunit interface; other site 592022007795 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592022007796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022007797 dimer interface [polypeptide binding]; other site 592022007798 conserved gate region; other site 592022007799 ABC-ATPase subunit interface; other site 592022007800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592022007801 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 592022007802 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 592022007803 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022007804 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022007805 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022007806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022007807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022007808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022007809 Coenzyme A binding pocket [chemical binding]; other site 592022007810 Staphylococcal nuclease homologues; Region: SNc; smart00318 592022007811 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 592022007812 Catalytic site; other site 592022007813 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 592022007814 malate:quinone oxidoreductase; Validated; Region: PRK05257 592022007815 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 592022007816 PEP synthetase regulatory protein; Provisional; Region: PRK05339 592022007817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022007818 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022007819 active site 592022007820 motif I; other site 592022007821 motif II; other site 592022007822 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592022007823 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 592022007824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022007825 active site 592022007826 motif I; other site 592022007827 motif II; other site 592022007828 Uncharacterized conserved protein [Function unknown]; Region: COG4278 592022007829 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 592022007830 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 592022007831 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 592022007832 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592022007833 Bacterial transcriptional regulator; Region: IclR; pfam01614 592022007834 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 592022007835 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 592022007836 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592022007837 malate synthase G; Provisional; Region: PRK02999 592022007838 active site 592022007839 FAD binding domain; Region: FAD_binding_4; pfam01565 592022007840 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 592022007841 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592022007842 Cysteine-rich domain; Region: CCG; pfam02754 592022007843 Cysteine-rich domain; Region: CCG; pfam02754 592022007844 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592022007845 FAD binding domain; Region: FAD_binding_4; pfam01565 592022007846 L-lactate permease; Region: Lactate_perm; cl00701 592022007847 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 592022007848 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 592022007849 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022007850 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022007851 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592022007852 Walker A/P-loop; other site 592022007853 ATP binding site [chemical binding]; other site 592022007854 Q-loop/lid; other site 592022007855 ABC transporter signature motif; other site 592022007856 Walker B; other site 592022007857 D-loop; other site 592022007858 H-loop/switch region; other site 592022007859 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 592022007860 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 592022007861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022007862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022007863 DNA binding residues [nucleotide binding] 592022007864 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 592022007865 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022007866 yiaA/B two helix domain; Region: YiaAB; pfam05360 592022007867 Esterase/lipase [General function prediction only]; Region: COG1647 592022007868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022007869 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 592022007870 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592022007871 active site 592022007872 dimer interface [polypeptide binding]; other site 592022007873 non-prolyl cis peptide bond; other site 592022007874 insertion regions; other site 592022007875 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022007876 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 592022007877 spermidine synthase; Validated; Region: speE; PRK01581 592022007878 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022007879 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 592022007880 putative active site [active] 592022007881 putative metal binding site [ion binding]; other site 592022007882 Predicted membrane protein [Function unknown]; Region: COG2323 592022007883 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 592022007884 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 592022007885 potential frameshift: common BLAST hit: gi|294499646|ref|YP_003563346.1| putative lipoprotein 592022007886 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592022007887 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 592022007888 HAMP domain; Region: HAMP; pfam00672 592022007889 dimerization interface [polypeptide binding]; other site 592022007890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022007891 dimer interface [polypeptide binding]; other site 592022007892 phosphorylation site [posttranslational modification] 592022007893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022007894 ATP binding site [chemical binding]; other site 592022007895 Mg2+ binding site [ion binding]; other site 592022007896 G-X-G motif; other site 592022007897 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022007898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022007899 active site 592022007900 phosphorylation site [posttranslational modification] 592022007901 intermolecular recognition site; other site 592022007902 dimerization interface [polypeptide binding]; other site 592022007903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022007904 DNA binding site [nucleotide binding] 592022007905 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592022007906 hypothetical protein; Provisional; Region: PRK06184 592022007907 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022007908 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 592022007909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022007910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022007911 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 592022007912 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 592022007913 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592022007914 E3 interaction surface; other site 592022007915 lipoyl attachment site [posttranslational modification]; other site 592022007916 e3 binding domain; Region: E3_binding; pfam02817 592022007917 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592022007918 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 592022007919 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 592022007920 TPP-binding site [chemical binding]; other site 592022007921 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 592022007922 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022007923 Transcriptional regulator PadR-like family; Region: PadR; cl17335 592022007924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022007925 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 592022007926 putative substrate translocation pore; other site 592022007927 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 592022007928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592022007929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022007930 NAD(P) binding site [chemical binding]; other site 592022007931 active site 592022007932 Predicted membrane protein [Function unknown]; Region: COG2311 592022007933 Protein of unknown function (DUF418); Region: DUF418; cl12135 592022007934 Protein of unknown function (DUF418); Region: DUF418; pfam04235 592022007935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 592022007936 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 592022007937 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592022007938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 592022007939 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592022007940 Walker A/P-loop; other site 592022007941 ATP binding site [chemical binding]; other site 592022007942 Q-loop/lid; other site 592022007943 ABC transporter signature motif; other site 592022007944 Walker B; other site 592022007945 D-loop; other site 592022007946 H-loop/switch region; other site 592022007947 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 592022007948 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592022007949 Walker A/P-loop; other site 592022007950 ATP binding site [chemical binding]; other site 592022007951 Q-loop/lid; other site 592022007952 ABC transporter signature motif; other site 592022007953 Walker B; other site 592022007954 D-loop; other site 592022007955 H-loop/switch region; other site 592022007956 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 592022007957 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592022007958 TM-ABC transporter signature motif; other site 592022007959 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592022007960 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592022007961 TM-ABC transporter signature motif; other site 592022007962 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 592022007963 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 592022007964 dimerization interface [polypeptide binding]; other site 592022007965 ligand binding site [chemical binding]; other site 592022007966 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 592022007967 Nitrogen regulatory protein P-II; Region: P-II; smart00938 592022007968 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 592022007969 aminobenzoyl-glutamate transport protein, frameshift 592022007970 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 592022007971 active site 592022007972 putative catalytic site [active] 592022007973 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022007974 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 592022007975 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022007976 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592022007977 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022007978 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 592022007979 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 592022007980 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022007981 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 592022007982 Predicted membrane protein [Function unknown]; Region: COG4640 592022007983 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 592022007984 YARHG domain; Region: YARHG; pfam13308 592022007985 PAS domain; Region: PAS_9; pfam13426 592022007986 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022007987 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022007988 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022007989 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592022007990 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 592022007991 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592022007992 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 592022007993 putative dimer interface [polypeptide binding]; other site 592022007994 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 592022007995 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592022007996 Walker A/P-loop; other site 592022007997 ATP binding site [chemical binding]; other site 592022007998 Q-loop/lid; other site 592022007999 ABC transporter signature motif; other site 592022008000 Walker B; other site 592022008001 D-loop; other site 592022008002 H-loop/switch region; other site 592022008003 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 592022008004 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022008005 ABC-ATPase subunit interface; other site 592022008006 dimer interface [polypeptide binding]; other site 592022008007 putative PBP binding regions; other site 592022008008 cobyric acid synthase; Provisional; Region: PRK00784 592022008009 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592022008010 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592022008011 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 592022008012 catalytic triad [active] 592022008013 Uncharacterized conserved protein [Function unknown]; Region: COG1434 592022008014 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 592022008015 putative active site [active] 592022008016 amino acid transporter; Region: 2A0306; TIGR00909 592022008017 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 592022008018 dimer interface [polypeptide binding]; other site 592022008019 FMN binding site [chemical binding]; other site 592022008020 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 592022008021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022008022 NAD(P) binding site [chemical binding]; other site 592022008023 active site 592022008024 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 592022008025 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 592022008026 tetramer interface [polypeptide binding]; other site 592022008027 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022008028 active site 592022008029 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 592022008030 active site 592022008031 dimer interface [polypeptide binding]; other site 592022008032 magnesium binding site [ion binding]; other site 592022008033 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022008034 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022008035 DNA binding site [nucleotide binding] 592022008036 domain linker motif; other site 592022008037 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 592022008038 putative dimerization interface [polypeptide binding]; other site 592022008039 putative ligand binding site [chemical binding]; other site 592022008040 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 592022008041 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 592022008042 active site 592022008043 intersubunit interface [polypeptide binding]; other site 592022008044 catalytic residue [active] 592022008045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008046 D-galactonate transporter; Region: 2A0114; TIGR00893 592022008047 putative substrate translocation pore; other site 592022008048 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022008049 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592022008050 substrate binding site [chemical binding]; other site 592022008051 ATP binding site [chemical binding]; other site 592022008052 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592022008053 phytoene desaturase; Region: crtI_fam; TIGR02734 592022008054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022008055 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 592022008056 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022008057 active site 592022008058 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 592022008059 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 592022008060 putative acyl-acceptor binding pocket; other site 592022008061 Protein of unknown function (DUF422); Region: DUF422; cl00991 592022008062 High-affinity nickel-transport protein; Region: NicO; cl00964 592022008063 UreD urease accessory protein; Region: UreD; cl00530 592022008064 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592022008065 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 592022008066 UreF; Region: UreF; pfam01730 592022008067 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 592022008068 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 592022008069 dimer interface [polypeptide binding]; other site 592022008070 catalytic residues [active] 592022008071 urease subunit alpha; Reviewed; Region: ureC; PRK13207 592022008072 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 592022008073 subunit interactions [polypeptide binding]; other site 592022008074 active site 592022008075 flap region; other site 592022008076 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 592022008077 gamma-beta subunit interface [polypeptide binding]; other site 592022008078 alpha-beta subunit interface [polypeptide binding]; other site 592022008079 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 592022008080 alpha-gamma subunit interface [polypeptide binding]; other site 592022008081 beta-gamma subunit interface [polypeptide binding]; other site 592022008082 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 592022008083 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592022008084 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592022008085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008086 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022008087 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022008088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 592022008091 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 592022008092 dimer interface [polypeptide binding]; other site 592022008093 FMN binding site [chemical binding]; other site 592022008094 NADPH bind site [chemical binding]; other site 592022008095 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 592022008096 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 592022008097 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592022008098 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592022008099 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592022008100 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022008101 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 592022008102 NodB motif; other site 592022008103 putative active site [active] 592022008104 putative catalytic site [active] 592022008105 putative Zn binding site [ion binding]; other site 592022008106 Predicted esterase [General function prediction only]; Region: COG0400 592022008107 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 592022008108 Transglycosylase; Region: Transgly; pfam00912 592022008109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022008110 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 592022008111 EamA-like transporter family; Region: EamA; pfam00892 592022008112 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592022008113 EamA-like transporter family; Region: EamA; pfam00892 592022008114 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022008115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022008116 DNA-binding site [nucleotide binding]; DNA binding site 592022008117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022008118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022008119 homodimer interface [polypeptide binding]; other site 592022008120 catalytic residue [active] 592022008121 YtkA-like; Region: YtkA; pfam13115 592022008122 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 592022008123 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592022008124 potential catalytic triad [active] 592022008125 conserved cys residue [active] 592022008126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592022008127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022008128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022008129 Walker A/P-loop; other site 592022008130 ATP binding site [chemical binding]; other site 592022008131 Q-loop/lid; other site 592022008132 ABC transporter signature motif; other site 592022008133 Walker B; other site 592022008134 D-loop; other site 592022008135 H-loop/switch region; other site 592022008136 Copper resistance protein D; Region: CopD; cl00563 592022008137 CopC domain; Region: CopC; pfam04234 592022008138 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 592022008139 Protein of unknown function (DUF867); Region: DUF867; pfam05908 592022008140 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 592022008141 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 592022008142 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 592022008143 dimerization interface [polypeptide binding]; other site 592022008144 DPS ferroxidase diiron center [ion binding]; other site 592022008145 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 592022008146 dinuclear metal binding motif [ion binding]; other site 592022008147 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 592022008148 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592022008149 Domain of unknown function DUF21; Region: DUF21; pfam01595 592022008150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592022008151 Transporter associated domain; Region: CorC_HlyC; smart01091 592022008152 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 592022008153 SpoOM protein; Region: Spo0M; pfam07070 592022008154 FOG: CBS domain [General function prediction only]; Region: COG0517 592022008155 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 592022008156 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 592022008157 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592022008158 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 592022008159 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 592022008160 [2Fe-2S] cluster binding site [ion binding]; other site 592022008161 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 592022008162 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 592022008163 hinge; other site 592022008164 active site 592022008165 prephenate dehydrogenase; Validated; Region: PRK08507 592022008166 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 592022008167 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 592022008168 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 592022008169 Tetramer interface [polypeptide binding]; other site 592022008170 active site 592022008171 FMN-binding site [chemical binding]; other site 592022008172 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 592022008173 Chorismate mutase type II; Region: CM_2; cl00693 592022008174 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 592022008175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008176 Coenzyme A binding pocket [chemical binding]; other site 592022008177 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 592022008178 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 592022008179 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 592022008180 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592022008181 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 592022008182 homodimer interface [polypeptide binding]; other site 592022008183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022008184 catalytic residue [active] 592022008185 allantoate amidohydrolase; Reviewed; Region: PRK09290 592022008186 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 592022008187 active site 592022008188 metal binding site [ion binding]; metal-binding site 592022008189 dimer interface [polypeptide binding]; other site 592022008190 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 592022008191 DRTGG domain; Region: DRTGG; pfam07085 592022008192 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 592022008193 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022008194 Domain of unknown function DUF77; Region: DUF77; pfam01910 592022008195 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 592022008196 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022008197 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 592022008198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022008199 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022008200 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022008201 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022008202 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 592022008203 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 592022008204 tetramer interface [polypeptide binding]; other site 592022008205 heme binding pocket [chemical binding]; other site 592022008206 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 592022008207 Na2 binding site [ion binding]; other site 592022008208 putative substrate binding site 1 [chemical binding]; other site 592022008209 Na binding site 1 [ion binding]; other site 592022008210 putative substrate binding site 2 [chemical binding]; other site 592022008211 Predicted membrane protein [Function unknown]; Region: COG3766 592022008212 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 592022008213 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 592022008214 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 592022008215 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592022008216 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592022008217 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592022008218 phosphate binding site [ion binding]; other site 592022008219 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 592022008220 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592022008221 Catalytic site [active] 592022008222 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 592022008223 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 592022008224 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 592022008225 active site 592022008226 homodimer interface [polypeptide binding]; other site 592022008227 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 592022008228 CHY zinc finger; Region: zf-CHY; pfam05495 592022008229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022008230 dimerization interface [polypeptide binding]; other site 592022008231 putative DNA binding site [nucleotide binding]; other site 592022008232 putative Zn2+ binding site [ion binding]; other site 592022008233 Uncharacterized conserved protein [Function unknown]; Region: COG1359 592022008234 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 592022008235 dimer interface [polypeptide binding]; other site 592022008236 FMN binding site [chemical binding]; other site 592022008237 NADPH bind site [chemical binding]; other site 592022008238 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 592022008239 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 592022008240 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 592022008241 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022008242 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022008243 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022008244 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022008245 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022008246 active site 592022008247 metal binding site [ion binding]; metal-binding site 592022008248 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 592022008249 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 592022008250 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 592022008251 DinB family; Region: DinB; cl17821 592022008252 DinB superfamily; Region: DinB_2; pfam12867 592022008253 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592022008254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022008255 S-adenosylmethionine binding site [chemical binding]; other site 592022008256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 592022008257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 592022008258 phosphopeptide binding site; other site 592022008259 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022008260 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 592022008261 DNA binding site [nucleotide binding] 592022008262 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 592022008263 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 592022008264 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 592022008265 putative dimer interface [polypeptide binding]; other site 592022008266 active site pocket [active] 592022008267 putative cataytic base [active] 592022008268 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022008269 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022008270 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022008271 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022008272 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022008273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008274 Coenzyme A binding pocket [chemical binding]; other site 592022008275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008276 H+ Antiporter protein; Region: 2A0121; TIGR00900 592022008277 putative substrate translocation pore; other site 592022008278 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022008279 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 592022008280 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 592022008281 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 592022008282 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 592022008283 dimer interface [polypeptide binding]; other site 592022008284 Citrate synthase; Region: Citrate_synt; pfam00285 592022008285 active site 592022008286 citrylCoA binding site [chemical binding]; other site 592022008287 oxalacetate/citrate binding site [chemical binding]; other site 592022008288 coenzyme A binding site [chemical binding]; other site 592022008289 catalytic triad [active] 592022008290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022008291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022008292 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 592022008293 putative dimerization interface [polypeptide binding]; other site 592022008294 EamA-like transporter family; Region: EamA; pfam00892 592022008295 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022008296 EamA-like transporter family; Region: EamA; pfam00892 592022008297 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022008298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022008299 DNA-binding site [nucleotide binding]; DNA binding site 592022008300 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022008301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022008302 homodimer interface [polypeptide binding]; other site 592022008303 catalytic residue [active] 592022008304 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 592022008305 B12 binding domain; Region: B12-binding_2; pfam02607 592022008306 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 592022008307 B12 binding site [chemical binding]; other site 592022008308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022008309 putative active site [active] 592022008310 heme pocket [chemical binding]; other site 592022008311 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022008312 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022008313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008314 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 592022008315 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 592022008316 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022008317 Predicted membrane protein [Function unknown]; Region: COG2261 592022008318 Clp protease; Region: CLP_protease; pfam00574 592022008319 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592022008320 oligomer interface [polypeptide binding]; other site 592022008321 active site residues [active] 592022008322 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022008323 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 592022008324 DNA binding residues [nucleotide binding] 592022008325 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 592022008326 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 592022008327 nucleotide binding site/active site [active] 592022008328 HIT family signature motif; other site 592022008329 catalytic residue [active] 592022008330 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 592022008331 Aspartase; Region: Aspartase; cd01357 592022008332 active sites [active] 592022008333 tetramer interface [polypeptide binding]; other site 592022008334 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 592022008335 active site 592022008336 homodimer interface [polypeptide binding]; other site 592022008337 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022008338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022008339 non-specific DNA binding site [nucleotide binding]; other site 592022008340 salt bridge; other site 592022008341 sequence-specific DNA binding site [nucleotide binding]; other site 592022008342 chaperone protein DnaJ; Provisional; Region: PRK10767 592022008343 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 592022008344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008345 putative substrate translocation pore; other site 592022008346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022008347 dimerization interface [polypeptide binding]; other site 592022008348 putative DNA binding site [nucleotide binding]; other site 592022008349 putative Zn2+ binding site [ion binding]; other site 592022008350 Protein of unknown function, DUF606; Region: DUF606; pfam04657 592022008351 Protein of unknown function, DUF606; Region: DUF606; pfam04657 592022008352 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022008353 Transcriptional regulator; Region: Rrf2; pfam02082 592022008354 Rrf2 family protein; Region: rrf2_super; TIGR00738 592022008355 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 592022008356 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 592022008357 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592022008358 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 592022008359 putative NAD(P) binding site [chemical binding]; other site 592022008360 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 592022008361 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022008362 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022008363 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022008364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008365 Coenzyme A binding pocket [chemical binding]; other site 592022008366 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 592022008367 classical (c) SDRs; Region: SDR_c; cd05233 592022008368 NAD(P) binding site [chemical binding]; other site 592022008369 active site 592022008370 sulfite reductase subunit beta; Provisional; Region: PRK13504 592022008371 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592022008372 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592022008373 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 592022008374 Flavodoxin; Region: Flavodoxin_1; pfam00258 592022008375 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 592022008376 FAD binding pocket [chemical binding]; other site 592022008377 FAD binding motif [chemical binding]; other site 592022008378 catalytic residues [active] 592022008379 NAD binding pocket [chemical binding]; other site 592022008380 phosphate binding motif [ion binding]; other site 592022008381 beta-alpha-beta structure motif; other site 592022008382 YolD-like protein; Region: YolD; pfam08863 592022008383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022008385 putative substrate translocation pore; other site 592022008386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022008387 MarR family; Region: MarR; pfam01047 592022008388 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022008389 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 592022008390 DNA binding residues [nucleotide binding] 592022008391 dimer interface [polypeptide binding]; other site 592022008392 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 592022008393 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 592022008394 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022008395 Coenzyme A binding pocket [chemical binding]; other site 592022008396 Rhamnan synthesis protein F; Region: RgpF; pfam05045 592022008397 potential frameshift: common BLAST hit: gi|294499864|ref|YP_003563564.1| spore germination protein (amino acid permease) 592022008398 Spore germination protein; Region: Spore_permease; cl17796 592022008399 Spore germination protein; Region: Spore_permease; cl17796 592022008400 CAAX protease self-immunity; Region: Abi; pfam02517 592022008401 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 592022008402 glycosyltransferase, MGT family; Region: MGT; TIGR01426 592022008403 active site 592022008404 TDP-binding site; other site 592022008405 acceptor substrate-binding pocket; other site 592022008406 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592022008407 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 592022008408 FMN binding site [chemical binding]; other site 592022008409 active site 592022008410 substrate binding site [chemical binding]; other site 592022008411 catalytic residue [active] 592022008412 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 592022008413 active site 592022008414 catalytic triad [active] 592022008415 oxyanion hole [active] 592022008416 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592022008417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022008418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022008419 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 592022008420 imidazolonepropionase; Validated; Region: PRK09356 592022008421 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 592022008422 active site 592022008423 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 592022008424 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022008425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008426 Coenzyme A binding pocket [chemical binding]; other site 592022008427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008428 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 592022008429 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 592022008430 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 592022008431 Subunit I/III interface [polypeptide binding]; other site 592022008432 Subunit III/IV interface [polypeptide binding]; other site 592022008433 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 592022008434 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 592022008435 D-pathway; other site 592022008436 Putative ubiquinol binding site [chemical binding]; other site 592022008437 Low-spin heme (heme b) binding site [chemical binding]; other site 592022008438 Putative water exit pathway; other site 592022008439 Binuclear center (heme o3/CuB) [ion binding]; other site 592022008440 K-pathway; other site 592022008441 Putative proton exit pathway; other site 592022008442 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 592022008443 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 592022008444 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 592022008445 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 592022008446 active site residue [active] 592022008447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022008448 dimerization interface [polypeptide binding]; other site 592022008449 putative DNA binding site [nucleotide binding]; other site 592022008450 putative Zn2+ binding site [ion binding]; other site 592022008451 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592022008452 metal-binding site [ion binding] 592022008453 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592022008454 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592022008455 metal-binding site [ion binding] 592022008456 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592022008457 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592022008458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022008459 S-adenosylmethionine binding site [chemical binding]; other site 592022008460 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 592022008461 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 592022008462 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022008463 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022008464 active site 592022008465 metal binding site [ion binding]; metal-binding site 592022008466 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022008467 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008468 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022008469 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008470 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592022008471 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592022008472 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592022008473 catalytic residues [active] 592022008474 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 592022008475 active site 592022008476 catalytic site [active] 592022008477 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592022008478 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022008479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008480 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 592022008481 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022008482 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022008483 Prostaglandin dehydrogenases; Region: PGDH; cd05288 592022008484 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 592022008485 NAD(P) binding site [chemical binding]; other site 592022008486 substrate binding site [chemical binding]; other site 592022008487 dimer interface [polypeptide binding]; other site 592022008488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 592022008489 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022008490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022008491 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022008492 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022008493 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 592022008494 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 592022008495 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 592022008496 Thioredoxin; Region: Thioredoxin_4; pfam13462 592022008497 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 592022008498 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 592022008499 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 592022008500 Penicillinase repressor; Region: Pencillinase_R; cl17580 592022008501 YvrJ protein family; Region: YvrJ; pfam12841 592022008502 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 592022008503 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 592022008504 Divergent AAA domain; Region: AAA_4; pfam04326 592022008505 hypothetical protein; Validated; Region: PRK06769 592022008506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022008507 active site 592022008508 motif I; other site 592022008509 motif II; other site 592022008510 Protein of unknown function (DUF867); Region: DUF867; pfam05908 592022008511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022008512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022008513 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 592022008514 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 592022008515 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 592022008516 G1 box; other site 592022008517 putative GEF interaction site [polypeptide binding]; other site 592022008518 GTP/Mg2+ binding site [chemical binding]; other site 592022008519 Switch I region; other site 592022008520 G2 box; other site 592022008521 G3 box; other site 592022008522 Switch II region; other site 592022008523 G4 box; other site 592022008524 G5 box; other site 592022008525 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 592022008526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022008527 DNA-binding site [nucleotide binding]; DNA binding site 592022008528 RNA-binding motif; other site 592022008529 Predicted membrane protein [Function unknown]; Region: COG2323 592022008530 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 592022008531 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592022008532 NAD binding site [chemical binding]; other site 592022008533 substrate binding site [chemical binding]; other site 592022008534 putative active site [active] 592022008535 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 592022008536 Double zinc ribbon; Region: DZR; pfam12773 592022008537 Protease prsW family; Region: PrsW-protease; cl15823 592022008538 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 592022008539 dimanganese center [ion binding]; other site 592022008540 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022008541 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 592022008542 dimanganese center [ion binding]; other site 592022008543 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 592022008544 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 592022008545 putative ligand binding residues [chemical binding]; other site 592022008546 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 592022008547 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592022008548 Walker A/P-loop; other site 592022008549 ATP binding site [chemical binding]; other site 592022008550 Q-loop/lid; other site 592022008551 ABC transporter signature motif; other site 592022008552 Walker B; other site 592022008553 D-loop; other site 592022008554 H-loop/switch region; other site 592022008555 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022008556 ABC-ATPase subunit interface; other site 592022008557 dimer interface [polypeptide binding]; other site 592022008558 putative PBP binding regions; other site 592022008559 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 592022008560 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022008561 ABC-ATPase subunit interface; other site 592022008562 dimer interface [polypeptide binding]; other site 592022008563 putative PBP binding regions; other site 592022008564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008565 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022008566 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022008567 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022008568 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 592022008569 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 592022008570 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592022008571 Catalytic site [active] 592022008572 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592022008573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 592022008574 Protein of unknown function (DUF975); Region: DUF975; cl10504 592022008575 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 592022008576 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592022008577 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592022008578 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592022008579 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 592022008580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022008581 catalytic residue [active] 592022008582 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 592022008583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022008584 motif II; other site 592022008585 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 592022008586 MutS domain III; Region: MutS_III; pfam05192 592022008587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022008588 Walker A/P-loop; other site 592022008589 ATP binding site [chemical binding]; other site 592022008590 Q-loop/lid; other site 592022008591 ABC transporter signature motif; other site 592022008592 Walker B; other site 592022008593 D-loop; other site 592022008594 H-loop/switch region; other site 592022008595 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 592022008596 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 592022008597 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 592022008598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022008599 non-specific DNA binding site [nucleotide binding]; other site 592022008600 salt bridge; other site 592022008601 sequence-specific DNA binding site [nucleotide binding]; other site 592022008602 Cupin domain; Region: Cupin_2; pfam07883 592022008603 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 592022008604 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592022008605 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022008606 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022008607 DNA binding site [nucleotide binding] 592022008608 domain linker motif; other site 592022008609 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 592022008610 dimerization interface [polypeptide binding]; other site 592022008611 ligand binding site [chemical binding]; other site 592022008612 Predicted transcriptional regulator [Transcription]; Region: COG1959 592022008613 Transcriptional regulator; Region: Rrf2; pfam02082 592022008614 SnoaL-like domain; Region: SnoaL_2; pfam12680 592022008615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022008616 Radical SAM superfamily; Region: Radical_SAM; pfam04055 592022008617 FeS/SAM binding site; other site 592022008618 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022008619 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 592022008620 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 592022008621 folate binding site [chemical binding]; other site 592022008622 NADP+ binding site [chemical binding]; other site 592022008623 Predicted transcriptional regulator [Transcription]; Region: COG2378 592022008624 HTH domain; Region: HTH_11; pfam08279 592022008625 WYL domain; Region: WYL; pfam13280 592022008626 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592022008627 Cytochrome P450; Region: p450; pfam00067 592022008628 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 592022008629 Flavodoxin; Region: Flavodoxin_1; pfam00258 592022008630 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 592022008631 FAD binding pocket [chemical binding]; other site 592022008632 FAD binding motif [chemical binding]; other site 592022008633 catalytic residues [active] 592022008634 NAD binding pocket [chemical binding]; other site 592022008635 phosphate binding motif [ion binding]; other site 592022008636 beta-alpha-beta structure motif; other site 592022008637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022008638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022008639 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 592022008640 dimanganese center [ion binding]; other site 592022008641 CotJB protein; Region: CotJB; pfam12652 592022008642 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 592022008643 LysE type translocator; Region: LysE; cl00565 592022008644 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592022008645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022008646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022008647 Histidine kinase; Region: HisKA_3; pfam07730 592022008648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022008649 ATP binding site [chemical binding]; other site 592022008650 Mg2+ binding site [ion binding]; other site 592022008651 G-X-G motif; other site 592022008652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022008653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022008654 active site 592022008655 phosphorylation site [posttranslational modification] 592022008656 intermolecular recognition site; other site 592022008657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022008658 DNA binding residues [nucleotide binding] 592022008659 dimerization interface [polypeptide binding]; other site 592022008660 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 592022008661 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 592022008662 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 592022008663 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022008664 YtkA-like; Region: YtkA; pfam13115 592022008665 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 592022008666 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 592022008667 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 592022008668 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 592022008669 active site 592022008670 intersubunit interactions; other site 592022008671 catalytic residue [active] 592022008672 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 592022008673 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022008674 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 592022008675 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592022008676 TPP-binding site [chemical binding]; other site 592022008677 dimer interface [polypeptide binding]; other site 592022008678 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592022008679 PYR/PP interface [polypeptide binding]; other site 592022008680 dimer interface [polypeptide binding]; other site 592022008681 TPP binding site [chemical binding]; other site 592022008682 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592022008683 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 592022008684 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 592022008685 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 592022008686 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022008687 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022008688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022008689 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 592022008690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592022008691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592022008692 Walker A/P-loop; other site 592022008693 ATP binding site [chemical binding]; other site 592022008694 Q-loop/lid; other site 592022008695 ABC transporter signature motif; other site 592022008696 Walker B; other site 592022008697 D-loop; other site 592022008698 H-loop/switch region; other site 592022008699 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592022008700 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592022008701 FtsX-like permease family; Region: FtsX; pfam02687 592022008702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022008703 dimerization interface [polypeptide binding]; other site 592022008704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022008705 dimer interface [polypeptide binding]; other site 592022008706 phosphorylation site [posttranslational modification] 592022008707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022008708 ATP binding site [chemical binding]; other site 592022008709 Mg2+ binding site [ion binding]; other site 592022008710 G-X-G motif; other site 592022008711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022008712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022008713 active site 592022008714 phosphorylation site [posttranslational modification] 592022008715 intermolecular recognition site; other site 592022008716 dimerization interface [polypeptide binding]; other site 592022008717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022008718 DNA binding site [nucleotide binding] 592022008719 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 592022008720 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 592022008721 GAF domain; Region: GAF; pfam01590 592022008722 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592022008723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022008724 phosphorylation site [posttranslational modification] 592022008725 dimer interface [polypeptide binding]; other site 592022008726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022008727 ATP binding site [chemical binding]; other site 592022008728 Mg2+ binding site [ion binding]; other site 592022008729 G-X-G motif; other site 592022008730 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022008731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008732 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592022008733 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592022008734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008735 Coenzyme A binding pocket [chemical binding]; other site 592022008736 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 592022008737 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 592022008738 DNA binding residues [nucleotide binding] 592022008739 putative dimer interface [polypeptide binding]; other site 592022008740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022008741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022008742 active site 592022008743 catalytic tetrad [active] 592022008744 EamA-like transporter family; Region: EamA; pfam00892 592022008745 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022008746 EamA-like transporter family; Region: EamA; pfam00892 592022008747 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592022008748 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022008749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022008750 Gas vesicle protein; Region: Gas_vesicle; pfam00741 592022008751 Gas vesicle protein K; Region: GvpK; pfam05121 592022008752 Gas vesicle protein; Region: Gas_vesicle; pfam00741 592022008753 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 592022008754 Gas vesicle protein G; Region: GvpG; pfam05120 592022008755 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 592022008756 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 592022008757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022008758 Walker A motif; other site 592022008759 ATP binding site [chemical binding]; other site 592022008760 Walker B motif; other site 592022008761 arginine finger; other site 592022008762 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 592022008763 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 592022008764 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 592022008765 Heat induced stress protein YflT; Region: YflT; pfam11181 592022008766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022008768 putative substrate translocation pore; other site 592022008769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022008770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022008771 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 592022008772 putative dimerization interface [polypeptide binding]; other site 592022008773 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022008774 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022008775 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 592022008776 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 592022008777 PhnA protein; Region: PhnA; pfam03831 592022008778 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 592022008779 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592022008780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592022008781 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 592022008782 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 592022008783 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 592022008784 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 592022008785 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592022008786 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592022008787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022008788 ABC-ATPase subunit interface; other site 592022008789 putative PBP binding loops; other site 592022008790 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 592022008791 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022008792 substrate binding pocket [chemical binding]; other site 592022008793 membrane-bound complex binding site; other site 592022008794 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592022008795 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592022008796 Walker A/P-loop; other site 592022008797 ATP binding site [chemical binding]; other site 592022008798 Q-loop/lid; other site 592022008799 ABC transporter signature motif; other site 592022008800 Walker B; other site 592022008801 D-loop; other site 592022008802 H-loop/switch region; other site 592022008803 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 592022008804 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 592022008805 active site 592022008806 iron coordination sites [ion binding]; other site 592022008807 benzoate transport; Region: 2A0115; TIGR00895 592022008808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008809 putative substrate translocation pore; other site 592022008810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022008811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022008812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008813 Coenzyme A binding pocket [chemical binding]; other site 592022008814 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 592022008815 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 592022008816 metal binding site [ion binding]; metal-binding site 592022008817 dimer interface [polypeptide binding]; other site 592022008818 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592022008819 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592022008820 active site 592022008821 non-prolyl cis peptide bond; other site 592022008822 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 592022008823 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592022008824 active site 592022008825 dimer interface [polypeptide binding]; other site 592022008826 non-prolyl cis peptide bond; other site 592022008827 insertion regions; other site 592022008828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022008829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592022008830 active site 592022008831 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592022008832 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 592022008833 putative NAD(P) binding site [chemical binding]; other site 592022008834 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022008835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022008836 active site 592022008837 phosphorylation site [posttranslational modification] 592022008838 intermolecular recognition site; other site 592022008839 dimerization interface [polypeptide binding]; other site 592022008840 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022008841 DNA binding site [nucleotide binding] 592022008842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022008843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 592022008844 dimer interface [polypeptide binding]; other site 592022008845 phosphorylation site [posttranslational modification] 592022008846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022008847 ATP binding site [chemical binding]; other site 592022008848 Mg2+ binding site [ion binding]; other site 592022008849 G-X-G motif; other site 592022008850 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592022008851 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592022008852 Walker A/P-loop; other site 592022008853 ATP binding site [chemical binding]; other site 592022008854 Q-loop/lid; other site 592022008855 ABC transporter signature motif; other site 592022008856 Walker B; other site 592022008857 D-loop; other site 592022008858 H-loop/switch region; other site 592022008859 FtsX-like permease family; Region: FtsX; pfam02687 592022008860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022008861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008863 Dienelactone hydrolase family; Region: DLH; pfam01738 592022008864 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 592022008865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022008866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022008867 homodimer interface [polypeptide binding]; other site 592022008868 catalytic residue [active] 592022008869 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592022008870 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 592022008871 CPxP motif; other site 592022008872 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 592022008873 active site residue [active] 592022008874 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022008875 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 592022008876 CPxP motif; other site 592022008877 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592022008878 active site residue [active] 592022008879 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592022008880 active site residue [active] 592022008881 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592022008882 active site residue [active] 592022008883 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 592022008884 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 592022008885 CPxP motif; other site 592022008886 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 592022008887 putative homodimer interface [polypeptide binding]; other site 592022008888 putative homotetramer interface [polypeptide binding]; other site 592022008889 putative metal binding site [ion binding]; other site 592022008890 putative homodimer-homodimer interface [polypeptide binding]; other site 592022008891 putative allosteric switch controlling residues; other site 592022008892 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 592022008893 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 592022008894 NAD binding site [chemical binding]; other site 592022008895 homotetramer interface [polypeptide binding]; other site 592022008896 homodimer interface [polypeptide binding]; other site 592022008897 substrate binding site [chemical binding]; other site 592022008898 active site 592022008899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022008900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022008901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022008902 dimerization interface [polypeptide binding]; other site 592022008903 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592022008904 EamA-like transporter family; Region: EamA; pfam00892 592022008905 EamA-like transporter family; Region: EamA; pfam00892 592022008906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022008907 Coenzyme A binding pocket [chemical binding]; other site 592022008908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022008909 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 592022008910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022008911 DNA-binding site [nucleotide binding]; DNA binding site 592022008912 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 592022008913 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 592022008914 beta-galactosidase; Region: BGL; TIGR03356 592022008915 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 592022008916 Na binding site [ion binding]; other site 592022008917 substrate binding site [chemical binding]; other site 592022008918 Excalibur calcium-binding domain; Region: Excalibur; cl05460 592022008919 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 592022008920 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 592022008921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022008922 non-specific DNA binding site [nucleotide binding]; other site 592022008923 salt bridge; other site 592022008924 sequence-specific DNA binding site [nucleotide binding]; other site 592022008925 Cupin domain; Region: Cupin_2; pfam07883 592022008926 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592022008927 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592022008928 DNA binding site [nucleotide binding] 592022008929 active site 592022008930 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022008931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022008932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022008933 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 592022008934 putative dimerization interface [polypeptide binding]; other site 592022008935 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022008936 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022008937 active site 592022008938 metal binding site [ion binding]; metal-binding site 592022008939 histidinol-phosphatase; Provisional; Region: PRK07328 592022008940 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 592022008941 active site 592022008942 dimer interface [polypeptide binding]; other site 592022008943 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592022008944 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 592022008945 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 592022008946 glucose-1-dehydrogenase; Provisional; Region: PRK08936 592022008947 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 592022008948 NAD binding site [chemical binding]; other site 592022008949 homodimer interface [polypeptide binding]; other site 592022008950 active site 592022008951 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 592022008952 dimer interface [polypeptide binding]; other site 592022008953 FMN binding site [chemical binding]; other site 592022008954 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 592022008955 NAD(P) binding site [chemical binding]; other site 592022008956 catalytic residues [active] 592022008957 Predicted membrane protein [Function unknown]; Region: COG4325 592022008958 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 592022008959 Repair protein; Region: Repair_PSII; pfam04536 592022008960 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 592022008961 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022008962 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 592022008963 NodB motif; other site 592022008964 active site 592022008965 catalytic site [active] 592022008966 metal binding site [ion binding]; metal-binding site 592022008967 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022008968 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592022008969 active site 592022008970 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592022008971 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 592022008972 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022008973 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592022008974 azoreductase; Reviewed; Region: PRK00170 592022008975 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022008976 azoreductase; Reviewed; Region: PRK00170 592022008977 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022008978 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022008979 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022008980 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 592022008981 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 592022008982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022008983 Zn binding site [ion binding]; other site 592022008984 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 592022008985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022008986 Zn binding site [ion binding]; other site 592022008987 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 592022008988 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022008989 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022008990 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 592022008991 conserved hypothetical protein; Region: TIGR02231 592022008992 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 592022008993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 592022008994 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 592022008995 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 592022008996 Protein of unknown function DUF45; Region: DUF45; pfam01863 592022008997 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 592022008998 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022008999 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022009000 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022009001 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022009002 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022009003 DNA-binding site [nucleotide binding]; DNA binding site 592022009004 RNA-binding motif; other site 592022009005 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022009006 DNA-binding site [nucleotide binding]; DNA binding site 592022009007 RNA-binding motif; other site 592022009008 proline/glycine betaine transporter; Provisional; Region: PRK10642 592022009009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 592022009011 threonine synthase; Validated; Region: PRK08197 592022009012 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 592022009013 homodimer interface [polypeptide binding]; other site 592022009014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022009015 catalytic residue [active] 592022009016 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022009017 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022009018 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 592022009019 MarR family; Region: MarR_2; cl17246 592022009020 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022009021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009022 putative substrate translocation pore; other site 592022009023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022009025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022009026 non-specific DNA binding site [nucleotide binding]; other site 592022009027 salt bridge; other site 592022009028 sequence-specific DNA binding site [nucleotide binding]; other site 592022009029 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 592022009030 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 592022009031 active site 592022009032 substrate binding pocket [chemical binding]; other site 592022009033 homodimer interaction site [polypeptide binding]; other site 592022009034 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592022009035 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592022009036 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 592022009037 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 592022009038 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 592022009039 putative active site [active] 592022009040 putative catalytic site [active] 592022009041 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 592022009042 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 592022009043 Protein of unknown function DUF111; Region: DUF111; cl03398 592022009044 hypothetical protein; Provisional; Region: PRK04194 592022009045 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 592022009046 AIR carboxylase; Region: AIRC; smart01001 592022009047 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 592022009048 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 592022009049 Ligand Binding Site [chemical binding]; other site 592022009050 D-mannonate oxidoreductase; Provisional; Region: PRK08277 592022009051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022009052 NAD(P) binding site [chemical binding]; other site 592022009053 active site 592022009054 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 592022009055 Glucuronate isomerase; Region: UxaC; pfam02614 592022009056 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 592022009057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592022009058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592022009059 nucleotide binding site [chemical binding]; other site 592022009060 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 592022009061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022009062 ABC transporter signature motif; other site 592022009063 Walker B; other site 592022009064 D-loop; other site 592022009065 H-loop/switch region; other site 592022009066 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 592022009067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022009068 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022009069 active site 592022009070 motif I; other site 592022009071 motif II; other site 592022009072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022009073 Cupin domain; Region: Cupin_2; cl17218 592022009074 Erythromycin esterase; Region: Erythro_esteras; cl17110 592022009075 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 592022009076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022009077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022009078 dimerization interface [polypeptide binding]; other site 592022009079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022009080 dimer interface [polypeptide binding]; other site 592022009081 phosphorylation site [posttranslational modification] 592022009082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022009083 ATP binding site [chemical binding]; other site 592022009084 Mg2+ binding site [ion binding]; other site 592022009085 G-X-G motif; other site 592022009086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022009087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022009088 active site 592022009089 phosphorylation site [posttranslational modification] 592022009090 intermolecular recognition site; other site 592022009091 dimerization interface [polypeptide binding]; other site 592022009092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022009093 DNA binding site [nucleotide binding] 592022009094 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022009095 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592022009096 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 592022009097 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 592022009098 Walker A/P-loop; other site 592022009099 ATP binding site [chemical binding]; other site 592022009100 Q-loop/lid; other site 592022009101 ABC transporter signature motif; other site 592022009102 Walker B; other site 592022009103 D-loop; other site 592022009104 H-loop/switch region; other site 592022009105 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 592022009106 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 592022009107 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 592022009108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022009109 salt bridge; other site 592022009110 non-specific DNA binding site [nucleotide binding]; other site 592022009111 sequence-specific DNA binding site [nucleotide binding]; other site 592022009112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022009113 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022009114 Coenzyme A binding pocket [chemical binding]; other site 592022009115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022009116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592022009118 dimerization interface [polypeptide binding]; other site 592022009119 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 592022009120 classical (c) SDRs; Region: SDR_c; cd05233 592022009121 NAD(P) binding site [chemical binding]; other site 592022009122 active site 592022009123 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 592022009124 active site 592022009125 NTP binding site [chemical binding]; other site 592022009126 metal binding triad [ion binding]; metal-binding site 592022009127 antibiotic binding site [chemical binding]; other site 592022009128 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022009129 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592022009130 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592022009131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022009132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022009133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022009134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022009135 DNA binding site [nucleotide binding] 592022009136 domain linker motif; other site 592022009137 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 592022009138 dimerization interface [polypeptide binding]; other site 592022009139 ligand binding site [chemical binding]; other site 592022009140 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022009141 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592022009142 DNA interaction; other site 592022009143 Metal-binding active site; metal-binding site 592022009144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022009145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022009146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022009147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022009149 putative substrate translocation pore; other site 592022009150 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 592022009151 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 592022009152 tetrameric interface [polypeptide binding]; other site 592022009153 NAD binding site [chemical binding]; other site 592022009154 catalytic residues [active] 592022009155 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022009156 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592022009157 substrate binding site [chemical binding]; other site 592022009158 ATP binding site [chemical binding]; other site 592022009159 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 592022009160 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 592022009161 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592022009162 PYR/PP interface [polypeptide binding]; other site 592022009163 dimer interface [polypeptide binding]; other site 592022009164 TPP binding site [chemical binding]; other site 592022009165 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022009166 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 592022009167 TPP-binding site; other site 592022009168 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592022009169 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592022009170 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592022009171 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592022009172 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 592022009173 intersubunit interface [polypeptide binding]; other site 592022009174 active site 592022009175 zinc binding site [ion binding]; other site 592022009176 Na+ binding site [ion binding]; other site 592022009177 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022009178 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592022009179 Metal-binding active site; metal-binding site 592022009180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009181 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 592022009182 putative substrate translocation pore; other site 592022009183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009184 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022009185 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592022009186 Metal-binding active site; metal-binding site 592022009187 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592022009188 regulatory protein interface [polypeptide binding]; other site 592022009189 active site 592022009190 regulatory phosphorylation site [posttranslational modification]; other site 592022009191 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592022009192 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592022009193 putative NAD(P) binding site [chemical binding]; other site 592022009194 putative substrate binding site [chemical binding]; other site 592022009195 catalytic Zn binding site [ion binding]; other site 592022009196 structural Zn binding site [ion binding]; other site 592022009197 dimer interface [polypeptide binding]; other site 592022009198 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 592022009199 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 592022009200 DNA binding residues [nucleotide binding] 592022009201 putative dimer interface [polypeptide binding]; other site 592022009202 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 592022009203 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 592022009204 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 592022009205 Mg binding site [ion binding]; other site 592022009206 nucleotide binding site [chemical binding]; other site 592022009207 putative protofilament interface [polypeptide binding]; other site 592022009208 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022009209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022009210 DNA-binding site [nucleotide binding]; DNA binding site 592022009211 RNA-binding motif; other site 592022009212 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 592022009213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022009214 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 592022009215 dimer interface [polypeptide binding]; other site 592022009216 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022009217 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022009218 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022009219 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 592022009220 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 592022009221 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 592022009222 dimerization interface [polypeptide binding]; other site 592022009223 putative active cleft [active] 592022009224 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 592022009225 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 592022009226 Cl binding site [ion binding]; other site 592022009227 oligomer interface [polypeptide binding]; other site 592022009228 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022009229 short chain dehydrogenase; Provisional; Region: PRK06701 592022009230 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 592022009231 NAD binding site [chemical binding]; other site 592022009232 metal binding site [ion binding]; metal-binding site 592022009233 active site 592022009234 Heat induced stress protein YflT; Region: YflT; pfam11181 592022009235 Preprotein translocase subunit; Region: YajC; cl00806 592022009236 short chain dehydrogenase; Provisional; Region: PRK06701 592022009237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022009238 NAD(P) binding site [chemical binding]; other site 592022009239 active site 592022009240 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 592022009241 active site 592022009242 Zn binding site [ion binding]; other site 592022009243 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 592022009244 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 592022009245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022009246 Coenzyme A binding pocket [chemical binding]; other site 592022009247 Spore germination protein; Region: Spore_permease; cl17796 592022009248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009249 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022009250 putative substrate translocation pore; other site 592022009251 hypothetical protein; Provisional; Region: PRK08296 592022009252 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592022009253 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 592022009254 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592022009255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022009256 DNA-binding site [nucleotide binding]; DNA binding site 592022009257 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592022009258 CAAX protease self-immunity; Region: Abi; pfam02517 592022009259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022009260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022009261 Coenzyme A binding pocket [chemical binding]; other site 592022009262 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 592022009263 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592022009264 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592022009265 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592022009266 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 592022009267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022009268 active site 592022009269 motif I; other site 592022009270 motif II; other site 592022009271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022009272 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592022009273 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 592022009274 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592022009275 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 592022009276 dimerization interface [polypeptide binding]; other site 592022009277 ligand binding site [chemical binding]; other site 592022009278 NADP binding site [chemical binding]; other site 592022009279 catalytic site [active] 592022009280 LysE type translocator; Region: LysE; cl00565 592022009281 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022009282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022009283 non-specific DNA binding site [nucleotide binding]; other site 592022009284 salt bridge; other site 592022009285 sequence-specific DNA binding site [nucleotide binding]; other site 592022009286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592022009287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022009288 Coenzyme A binding pocket [chemical binding]; other site 592022009289 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 592022009290 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 592022009291 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 592022009292 THF binding site; other site 592022009293 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 592022009294 substrate binding site [chemical binding]; other site 592022009295 THF binding site; other site 592022009296 zinc-binding site [ion binding]; other site 592022009297 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 592022009298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009299 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 592022009300 putative substrate translocation pore; other site 592022009301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009302 L-arabinose isomerase; Provisional; Region: PRK02929 592022009303 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 592022009304 hexamer (dimer of trimers) interface [polypeptide binding]; other site 592022009305 trimer interface [polypeptide binding]; other site 592022009306 substrate binding site [chemical binding]; other site 592022009307 Mn binding site [ion binding]; other site 592022009308 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 592022009309 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 592022009310 intersubunit interface [polypeptide binding]; other site 592022009311 active site 592022009312 Zn2+ binding site [ion binding]; other site 592022009313 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 592022009314 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 592022009315 putative N- and C-terminal domain interface [polypeptide binding]; other site 592022009316 putative active site [active] 592022009317 MgATP binding site [chemical binding]; other site 592022009318 catalytic site [active] 592022009319 metal binding site [ion binding]; metal-binding site 592022009320 putative carbohydrate binding site [chemical binding]; other site 592022009321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022009322 DNA-binding site [nucleotide binding]; DNA binding site 592022009323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022009324 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 592022009325 putative dimerization interface [polypeptide binding]; other site 592022009326 putative ligand binding site [chemical binding]; other site 592022009327 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 592022009328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022009329 Zn2+ binding site [ion binding]; other site 592022009330 Mg2+ binding site [ion binding]; other site 592022009331 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 592022009332 Nucleoside recognition; Region: Gate; pfam07670 592022009333 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 592022009334 Nucleoside recognition; Region: Gate; pfam07670 592022009335 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 592022009336 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 592022009337 G1 box; other site 592022009338 GTP/Mg2+ binding site [chemical binding]; other site 592022009339 Switch I region; other site 592022009340 G2 box; other site 592022009341 G3 box; other site 592022009342 Switch II region; other site 592022009343 G4 box; other site 592022009344 G5 box; other site 592022009345 FeoA domain; Region: FeoA; pfam04023 592022009346 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 592022009347 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 592022009348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592022009349 YtkA-like; Region: YtkA; pfam13115 592022009350 MarR family; Region: MarR; pfam01047 592022009351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022009352 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 592022009353 RNA polymerase factor sigma-70; Validated; Region: PRK06811 592022009354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022009355 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 592022009356 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 592022009357 putative dimer interface [polypeptide binding]; other site 592022009358 catalytic triad [active] 592022009359 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 592022009360 Protein of unknown function (DUF975); Region: DUF975; cl10504 592022009361 Bacterial SH3 domain; Region: SH3_3; cl17532 592022009362 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022009363 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022009364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 592022009365 MOSC domain; Region: MOSC; pfam03473 592022009366 3-alpha domain; Region: 3-alpha; pfam03475 592022009367 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 592022009368 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592022009369 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592022009370 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 592022009371 thymidylate kinase; Validated; Region: tmk; PRK00698 592022009372 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 592022009373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022009374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022009375 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592022009376 kynureninase; Region: kynureninase; TIGR01814 592022009377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022009378 catalytic residue [active] 592022009379 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 592022009380 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 592022009381 Putative cyclase; Region: Cyclase; cl00814 592022009382 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 592022009383 active site 1 [active] 592022009384 dimer interface [polypeptide binding]; other site 592022009385 hexamer interface [polypeptide binding]; other site 592022009386 active site 2 [active] 592022009387 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 592022009388 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 592022009389 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 592022009390 active site 592022009391 catalytic residues [active] 592022009392 metal binding site [ion binding]; metal-binding site 592022009393 DmpG-like communication domain; Region: DmpG_comm; pfam07836 592022009394 acetaldehyde dehydrogenase; Validated; Region: PRK08300 592022009395 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592022009396 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 592022009397 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 592022009398 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592022009399 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 592022009400 NAD binding site [chemical binding]; other site 592022009401 catalytic residues [active] 592022009402 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 592022009403 homotrimer interaction site [polypeptide binding]; other site 592022009404 putative active site [active] 592022009405 Amidohydrolase; Region: Amidohydro_2; pfam04909 592022009406 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 592022009407 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022009408 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022009409 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 592022009410 active site 592022009411 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 592022009412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592022009413 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 592022009414 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592022009415 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592022009416 ligand binding site [chemical binding]; other site 592022009417 flexible hinge region; other site 592022009418 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 592022009419 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592022009420 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 592022009421 ligand binding site [chemical binding]; other site 592022009422 flexible hinge region; other site 592022009423 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 592022009424 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592022009425 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 592022009426 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 592022009427 DNA binding residues [nucleotide binding] 592022009428 putative dimer interface [polypeptide binding]; other site 592022009429 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592022009430 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 592022009431 putative substrate binding site [chemical binding]; other site 592022009432 putative ATP binding site [chemical binding]; other site 592022009433 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 592022009434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009435 putative substrate translocation pore; other site 592022009436 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592022009437 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 592022009438 inhibitor binding site; inhibition site 592022009439 catalytic Zn binding site [ion binding]; other site 592022009440 structural Zn binding site [ion binding]; other site 592022009441 NADP binding site [chemical binding]; other site 592022009442 tetramer interface [polypeptide binding]; other site 592022009443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022009444 AAA domain; Region: AAA_22; pfam13401 592022009445 Walker A motif; other site 592022009446 ATP binding site [chemical binding]; other site 592022009447 Walker B motif; other site 592022009448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022009449 TPR motif; other site 592022009450 binding surface 592022009451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592022009452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022009453 binding surface 592022009454 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592022009455 TPR motif; other site 592022009456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592022009457 binding surface 592022009458 TPR motif; other site 592022009459 hypothetical protein; Provisional; Region: PRK07758 592022009460 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 592022009461 A new structural DNA glycosylase; Region: AlkD_like; cd06561 592022009462 active site 592022009463 Uncharacterized conserved protein [Function unknown]; Region: COG5646 592022009464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 592022009465 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 592022009466 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 592022009467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022009468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022009469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022009470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009471 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022009472 dimerization interface [polypeptide binding]; other site 592022009473 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 592022009474 MepB protein; Region: MepB; pfam08877 592022009475 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 592022009476 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 592022009477 oligomer interface [polypeptide binding]; other site 592022009478 metal binding site [ion binding]; metal-binding site 592022009479 metal binding site [ion binding]; metal-binding site 592022009480 putative Cl binding site [ion binding]; other site 592022009481 aspartate ring; other site 592022009482 basic sphincter; other site 592022009483 hydrophobic gate; other site 592022009484 periplasmic entrance; other site 592022009485 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 592022009486 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 592022009487 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 592022009488 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 592022009489 Zn binding site [ion binding]; other site 592022009490 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 592022009491 Dehydroquinase class II; Region: DHquinase_II; pfam01220 592022009492 trimer interface [polypeptide binding]; other site 592022009493 active site 592022009494 dimer interface [polypeptide binding]; other site 592022009495 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022009496 active site 592022009497 metal binding site [ion binding]; metal-binding site 592022009498 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 592022009499 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592022009500 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592022009501 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 592022009502 dimer interaction site [polypeptide binding]; other site 592022009503 substrate-binding tunnel; other site 592022009504 active site 592022009505 catalytic site [active] 592022009506 substrate binding site [chemical binding]; other site 592022009507 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 592022009508 Coenzyme A transferase; Region: CoA_trans; smart00882 592022009509 Coenzyme A transferase; Region: CoA_trans; cl17247 592022009510 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592022009511 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592022009512 shikimate binding site; other site 592022009513 NAD(P) binding site [chemical binding]; other site 592022009514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022009515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009516 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 592022009517 putative dimerization interface [polypeptide binding]; other site 592022009518 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592022009519 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 592022009520 putative NAD(P) binding site [chemical binding]; other site 592022009521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022009522 dimerization interface [polypeptide binding]; other site 592022009523 putative DNA binding site [nucleotide binding]; other site 592022009524 putative Zn2+ binding site [ion binding]; other site 592022009525 hypothetical protein; Provisional; Region: PRK06126 592022009526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592022009527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592022009528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022009529 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 592022009530 dimer interface [polypeptide binding]; other site 592022009531 Major royal jelly protein; Region: MRJP; pfam03022 592022009532 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022009533 classical (c) SDRs; Region: SDR_c; cd05233 592022009534 NAD(P) binding site [chemical binding]; other site 592022009535 active site 592022009536 polyol permease family; Region: 2A0118; TIGR00897 592022009537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009538 putative substrate translocation pore; other site 592022009539 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022009540 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592022009541 DNA interaction; other site 592022009542 Metal-binding active site; metal-binding site 592022009543 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592022009544 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022009545 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022009546 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022009547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592022009548 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592022009549 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592022009550 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592022009551 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592022009552 DNA interaction; other site 592022009553 Metal-binding active site; metal-binding site 592022009554 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022009555 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022009556 DNA binding site [nucleotide binding] 592022009557 domain linker motif; other site 592022009558 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 592022009559 dimerization interface [polypeptide binding]; other site 592022009560 ligand binding site [chemical binding]; other site 592022009561 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592022009562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022009563 active site 592022009564 phosphorylation site [posttranslational modification] 592022009565 intermolecular recognition site; other site 592022009566 dimerization interface [polypeptide binding]; other site 592022009567 LytTr DNA-binding domain; Region: LytTR; pfam04397 592022009568 PAS domain; Region: PAS_9; pfam13426 592022009569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022009570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022009571 dimer interface [polypeptide binding]; other site 592022009572 phosphorylation site [posttranslational modification] 592022009573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022009574 ATP binding site [chemical binding]; other site 592022009575 Mg2+ binding site [ion binding]; other site 592022009576 G-X-G motif; other site 592022009577 Response regulator receiver domain; Region: Response_reg; pfam00072 592022009578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022009579 active site 592022009580 phosphorylation site [posttranslational modification] 592022009581 intermolecular recognition site; other site 592022009582 dimerization interface [polypeptide binding]; other site 592022009583 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 592022009584 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592022009585 putative ligand binding site [chemical binding]; other site 592022009586 Low molecular weight phosphatase family; Region: LMWPc; cl00105 592022009587 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 592022009588 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 592022009589 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592022009590 NAD binding site [chemical binding]; other site 592022009591 catalytic Zn binding site [ion binding]; other site 592022009592 structural Zn binding site [ion binding]; other site 592022009593 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 592022009594 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 592022009595 potential frameshift: common BLAST hit: gi|294498522|ref|YP_003562222.1| anti-sigma-factor antagonist 592022009596 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 592022009597 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 592022009598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022009599 Coenzyme A binding pocket [chemical binding]; other site 592022009600 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592022009601 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592022009602 active site 1 [active] 592022009603 dimer interface [polypeptide binding]; other site 592022009604 hexamer interface [polypeptide binding]; other site 592022009605 active site 2 [active] 592022009606 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 592022009607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022009609 dimerization interface [polypeptide binding]; other site 592022009610 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 592022009611 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 592022009612 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592022009613 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 592022009614 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022009615 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022009616 TAP-like protein; Region: Abhydrolase_4; pfam08386 592022009617 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 592022009618 Isochorismatase family; Region: Isochorismatase; pfam00857 592022009619 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 592022009620 catalytic triad [active] 592022009621 dimer interface [polypeptide binding]; other site 592022009622 conserved cis-peptide bond; other site 592022009623 Predicted flavoprotein [General function prediction only]; Region: COG0431 592022009624 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022009625 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 592022009626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022009627 Zn binding site [ion binding]; other site 592022009628 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 592022009629 Zn binding site [ion binding]; other site 592022009630 Predicted membrane protein [Function unknown]; Region: COG2259 592022009631 malate dehydrogenase; Reviewed; Region: PRK06223 592022009632 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 592022009633 NAD(P) binding site [chemical binding]; other site 592022009634 dimer interface [polypeptide binding]; other site 592022009635 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022009636 substrate binding site [chemical binding]; other site 592022009637 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 592022009638 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 592022009639 Hexamer interface [polypeptide binding]; other site 592022009640 Hexagonal pore residue; other site 592022009641 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 592022009642 Hexamer/Pentamer interface [polypeptide binding]; other site 592022009643 central pore; other site 592022009644 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 592022009645 Propanediol utilisation protein PduL; Region: PduL; pfam06130 592022009646 Propanediol utilisation protein PduL; Region: PduL; pfam06130 592022009647 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 592022009648 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 592022009649 Hexamer interface [polypeptide binding]; other site 592022009650 Putative hexagonal pore residue; other site 592022009651 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 592022009652 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 592022009653 putative catalytic cysteine [active] 592022009654 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 592022009655 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 592022009656 putative hexamer interface [polypeptide binding]; other site 592022009657 putative hexagonal pore; other site 592022009658 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 592022009659 putative hexamer interface [polypeptide binding]; other site 592022009660 putative hexagonal pore; other site 592022009661 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 592022009662 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 592022009663 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 592022009664 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 592022009665 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 592022009666 nucleotide binding site [chemical binding]; other site 592022009667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 592022009668 nucleotide binding site [chemical binding]; other site 592022009669 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 592022009670 G1 box; other site 592022009671 GTP/Mg2+ binding site [chemical binding]; other site 592022009672 G2 box; other site 592022009673 Switch I region; other site 592022009674 G3 box; other site 592022009675 Switch II region; other site 592022009676 G4 box; other site 592022009677 G5 box; other site 592022009678 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 592022009679 putative hexamer interface [polypeptide binding]; other site 592022009680 putative hexagonal pore; other site 592022009681 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 592022009682 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 592022009683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022009684 active site 592022009685 phosphorylation site [posttranslational modification] 592022009686 intermolecular recognition site; other site 592022009687 dimerization interface [polypeptide binding]; other site 592022009688 ANTAR domain; Region: ANTAR; pfam03861 592022009689 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 592022009690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 592022009691 Histidine kinase; Region: HisKA_2; pfam07568 592022009692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022009693 ATP binding site [chemical binding]; other site 592022009694 Mg2+ binding site [ion binding]; other site 592022009695 G-X-G motif; other site 592022009696 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 592022009697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022009698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022009699 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 592022009700 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592022009701 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 592022009702 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 592022009703 hypothetical protein; Validated; Region: PRK06201 592022009704 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 592022009705 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592022009706 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592022009707 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592022009708 putative active site [active] 592022009709 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 592022009710 Citrate transporter; Region: CitMHS; pfam03600 592022009711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009712 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592022009713 putative substrate translocation pore; other site 592022009714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009715 putative substrate translocation pore; other site 592022009716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022009717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022009718 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 592022009719 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 592022009720 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 592022009721 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592022009722 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 592022009723 substrate-cofactor binding pocket; other site 592022009724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022009725 catalytic residue [active] 592022009726 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592022009727 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 592022009728 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 592022009729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022009730 S-adenosylmethionine binding site [chemical binding]; other site 592022009731 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 592022009732 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022009733 active site turn [active] 592022009734 phosphorylation site [posttranslational modification] 592022009735 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022009736 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 592022009737 HPr interaction site; other site 592022009738 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592022009739 active site 592022009740 phosphorylation site [posttranslational modification] 592022009741 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 592022009742 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 592022009743 putative active site [active] 592022009744 Predicted transcriptional regulators [Transcription]; Region: COG1378 592022009745 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 592022009746 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 592022009747 C-terminal domain interface [polypeptide binding]; other site 592022009748 sugar binding site [chemical binding]; other site 592022009749 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592022009750 EamA-like transporter family; Region: EamA; pfam00892 592022009751 EamA-like transporter family; Region: EamA; pfam00892 592022009752 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592022009753 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 592022009754 active site 592022009755 metal binding site [ion binding]; metal-binding site 592022009756 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592022009757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022009758 Coenzyme A binding pocket [chemical binding]; other site 592022009759 Protein of unknown function, DUF606; Region: DUF606; pfam04657 592022009760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022009761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022009763 dimerization interface [polypeptide binding]; other site 592022009764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022009766 putative substrate translocation pore; other site 592022009767 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592022009768 EamA-like transporter family; Region: EamA; pfam00892 592022009769 EamA-like transporter family; Region: EamA; pfam00892 592022009770 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022009771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022009772 DNA-binding site [nucleotide binding]; DNA binding site 592022009773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022009774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022009775 homodimer interface [polypeptide binding]; other site 592022009776 catalytic residue [active] 592022009777 Fumarase C C-terminus; Region: FumaraseC_C; pfam10415 592022009778 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022009779 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 592022009780 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 592022009781 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 592022009782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592022009783 classical (c) SDRs; Region: SDR_c; cd05233 592022009784 NAD(P) binding site [chemical binding]; other site 592022009785 active site 592022009786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022009787 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022009788 active site 592022009789 catalytic tetrad [active] 592022009790 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022009791 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 592022009792 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 592022009793 DNA binding residues [nucleotide binding] 592022009794 dimer interface [polypeptide binding]; other site 592022009795 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 592022009796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022009798 putative substrate translocation pore; other site 592022009799 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 592022009800 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 592022009801 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 592022009802 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 592022009803 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022009804 active site turn [active] 592022009805 phosphorylation site [posttranslational modification] 592022009806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022009807 YolD-like protein; Region: YolD; pfam08863 592022009808 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592022009809 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 592022009810 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592022009811 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 592022009812 conserved cys residue [active] 592022009813 CAAX protease self-immunity; Region: Abi; pfam02517 592022009814 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 592022009815 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 592022009816 active site 592022009817 homotetramer interface [polypeptide binding]; other site 592022009818 homodimer interface [polypeptide binding]; other site 592022009819 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 592022009820 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 592022009821 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 592022009822 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 592022009823 Predicted transcriptional regulators [Transcription]; Region: COG1695 592022009824 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592022009825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022009826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022009828 dimerization interface [polypeptide binding]; other site 592022009829 Uncharacterized conserved protein [Function unknown]; Region: COG4925 592022009830 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592022009831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009832 putative substrate translocation pore; other site 592022009833 YrhK-like protein; Region: YrhK; pfam14145 592022009834 Heat induced stress protein YflT; Region: YflT; pfam11181 592022009835 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 592022009836 malate dehydrogenase; Provisional; Region: PRK13529 592022009837 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592022009838 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 592022009839 NAD(P) binding site [chemical binding]; other site 592022009840 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 592022009841 DHH family; Region: DHH; pfam01368 592022009842 DinB superfamily; Region: DinB_2; pfam12867 592022009843 DinB family; Region: DinB; cl17821 592022009844 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 592022009845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022009846 motif II; other site 592022009847 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022009848 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 592022009849 Lipase (class 2); Region: Lipase_2; pfam01674 592022009850 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 592022009851 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592022009852 substrate binding [chemical binding]; other site 592022009853 active site 592022009854 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 592022009855 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 592022009856 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 592022009857 Ca binding site [ion binding]; other site 592022009858 active site 592022009859 catalytic site [active] 592022009860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022009861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022009862 DNA binding site [nucleotide binding] 592022009863 domain linker motif; other site 592022009864 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 592022009865 putative dimerization interface [polypeptide binding]; other site 592022009866 putative ligand binding site [chemical binding]; other site 592022009867 galactoside permease; Reviewed; Region: lacY; PRK09528 592022009868 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022009869 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022009870 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022009871 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022009872 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 592022009873 potential frameshift: common BLAST hit: gi|150392276|ref|YP_001322325.1| membrane protein 592022009874 potential frameshift: common BLAST hit: gi|150392276|ref|YP_001322325.1| membrane protein 592022009875 metal-dependent hydrolase; Provisional; Region: PRK13291 592022009876 DinB superfamily; Region: DinB_2; pfam12867 592022009877 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592022009878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592022009879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 592022009880 Domain of unknown function DUF; Region: DUF204; pfam02659 592022009881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592022009882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022009883 non-specific DNA binding site [nucleotide binding]; other site 592022009884 salt bridge; other site 592022009885 sequence-specific DNA binding site [nucleotide binding]; other site 592022009886 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 592022009887 SPW repeat; Region: SPW; pfam03779 592022009888 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 592022009889 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 592022009890 dimer interface [polypeptide binding]; other site 592022009891 putative functional site; other site 592022009892 putative MPT binding site; other site 592022009893 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 592022009894 trimer interface [polypeptide binding]; other site 592022009895 dimer interface [polypeptide binding]; other site 592022009896 putative active site [active] 592022009897 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 592022009898 MPT binding site; other site 592022009899 trimer interface [polypeptide binding]; other site 592022009900 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 592022009901 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 592022009902 Moco binding site; other site 592022009903 metal coordination site [ion binding]; other site 592022009904 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 592022009905 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 592022009906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022009907 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 592022009908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 592022009909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022009910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022009911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592022009912 dimerization interface [polypeptide binding]; other site 592022009913 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 592022009914 Citrate transporter; Region: CitMHS; pfam03600 592022009915 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 592022009916 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 592022009917 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 592022009918 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592022009919 oligomer interface [polypeptide binding]; other site 592022009920 active site residues [active] 592022009921 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592022009922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022009923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022009924 DNA binding residues [nucleotide binding] 592022009925 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 592022009926 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022009927 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022009928 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022009929 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022009930 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022009931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022009932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022009933 putative substrate translocation pore; other site 592022009934 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022009935 MarR family; Region: MarR; pfam01047 592022009936 RNA polymerase factor sigma-70; Validated; Region: PRK08295 592022009937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022009938 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 592022009939 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592022009940 DNA-binding site [nucleotide binding]; DNA binding site 592022009941 RNA-binding motif; other site 592022009942 putative transport protein YifK; Provisional; Region: PRK10746 592022009943 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 592022009944 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 592022009945 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 592022009946 Glutamate binding site [chemical binding]; other site 592022009947 homodimer interface [polypeptide binding]; other site 592022009948 NAD binding site [chemical binding]; other site 592022009949 catalytic residues [active] 592022009950 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 592022009951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 592022009952 YcxB-like protein; Region: YcxB; pfam14317 592022009953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022009954 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 592022009955 dimer interface [polypeptide binding]; other site 592022009956 putative metal binding site [ion binding]; other site 592022009957 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 592022009958 stage II sporulation protein P; Region: spore_II_P; TIGR02867 592022009959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022009960 PAS domain; Region: PAS_9; pfam13426 592022009961 putative active site [active] 592022009962 heme pocket [chemical binding]; other site 592022009963 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592022009964 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592022009965 metal binding site [ion binding]; metal-binding site 592022009966 active site 592022009967 I-site; other site 592022009968 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592022009969 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 592022009970 putative active site [active] 592022009971 putative metal binding site [ion binding]; other site 592022009972 PgaD-like protein; Region: PgaD; cl14676 592022009973 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 592022009974 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 592022009975 DXD motif; other site 592022009976 Ferritin-like domain; Region: Ferritin; pfam00210 592022009977 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 592022009978 ferroxidase diiron center [ion binding]; other site 592022009979 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 592022009980 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 592022009981 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 592022009982 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592022009983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022009984 S-adenosylmethionine binding site [chemical binding]; other site 592022009985 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592022009986 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592022009987 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 592022009988 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 592022009989 active site 592022009990 Zn binding site [ion binding]; other site 592022009991 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 592022009992 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 592022009993 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022009994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022009995 active site 592022009996 catalytic tetrad [active] 592022009997 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 592022009998 DinB superfamily; Region: DinB_2; pfam12867 592022009999 metal-dependent hydrolase; Provisional; Region: PRK13291 592022010000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 592022010001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010002 Coenzyme A binding pocket [chemical binding]; other site 592022010003 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 592022010004 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 592022010005 DNA binding residues [nucleotide binding] 592022010006 putative dimer interface [polypeptide binding]; other site 592022010007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022010008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022010009 active site 592022010010 catalytic tetrad [active] 592022010011 CAAX protease self-immunity; Region: Abi; pfam02517 592022010012 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 592022010013 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022010014 DNA binding residues [nucleotide binding] 592022010015 dimer interface [polypeptide binding]; other site 592022010016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022010017 putative substrate translocation pore; other site 592022010018 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 592022010019 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592022010020 substrate binding [chemical binding]; other site 592022010021 active site 592022010022 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 592022010023 YtxH-like protein; Region: YtxH; cl02079 592022010024 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 592022010025 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 592022010026 active site 592022010027 nucleophile elbow; other site 592022010028 FtsX-like permease family; Region: FtsX; pfam02687 592022010029 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592022010030 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592022010031 Walker A/P-loop; other site 592022010032 ATP binding site [chemical binding]; other site 592022010033 Q-loop/lid; other site 592022010034 ABC transporter signature motif; other site 592022010035 Walker B; other site 592022010036 D-loop; other site 592022010037 H-loop/switch region; other site 592022010038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022010039 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 592022010040 dimer interface [polypeptide binding]; other site 592022010041 phosphorylation site [posttranslational modification] 592022010042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010043 ATP binding site [chemical binding]; other site 592022010044 Mg2+ binding site [ion binding]; other site 592022010045 G-X-G motif; other site 592022010046 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022010047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022010048 active site 592022010049 phosphorylation site [posttranslational modification] 592022010050 intermolecular recognition site; other site 592022010051 dimerization interface [polypeptide binding]; other site 592022010052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022010053 DNA binding site [nucleotide binding] 592022010054 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 592022010055 substrate binding pocket [chemical binding]; other site 592022010056 substrate-Mg2+ binding site; other site 592022010057 aspartate-rich region 1; other site 592022010058 aspartate-rich region 2; other site 592022010059 Predicted membrane protein [Function unknown]; Region: COG1289 592022010060 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 592022010061 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592022010062 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 592022010063 putative homodimer interface [polypeptide binding]; other site 592022010064 putative homotetramer interface [polypeptide binding]; other site 592022010065 putative metal binding site [ion binding]; other site 592022010066 putative homodimer-homodimer interface [polypeptide binding]; other site 592022010067 putative allosteric switch controlling residues; other site 592022010068 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 592022010069 Competence protein J (ComJ); Region: ComJ; pfam11033 592022010070 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 592022010071 Part of AAA domain; Region: AAA_19; pfam13245 592022010072 Family description; Region: UvrD_C_2; pfam13538 592022010073 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022010074 substrate binding site [chemical binding]; other site 592022010075 oxyanion hole (OAH) forming residues; other site 592022010076 Predicted transcriptional regulators [Transcription]; Region: COG1733 592022010077 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592022010078 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 592022010079 CGNR zinc finger; Region: zf-CGNR; pfam11706 592022010080 HPP family; Region: HPP; pfam04982 592022010081 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592022010082 Cytochrome P450; Region: p450; cl12078 592022010083 Predicted membrane protein [Function unknown]; Region: COG2259 592022010084 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592022010085 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 592022010086 Ligand binding site; other site 592022010087 Putative Catalytic site; other site 592022010088 DXD motif; other site 592022010089 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 592022010090 active site 592022010091 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 592022010092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022010093 NAD(P) binding site [chemical binding]; other site 592022010094 active site 592022010095 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592022010096 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 592022010097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022010098 active site 592022010099 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592022010100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592022010101 active site 592022010102 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022010103 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022010104 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022010105 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 592022010106 heme-binding site [chemical binding]; other site 592022010107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592022010108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592022010109 dimer interface [polypeptide binding]; other site 592022010110 putative CheW interface [polypeptide binding]; other site 592022010111 transcriptional regulator Hpr; Provisional; Region: PRK13777 592022010112 MarR family; Region: MarR; pfam01047 592022010113 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 592022010114 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 592022010115 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 592022010116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022010117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022010118 DNA binding residues [nucleotide binding] 592022010119 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 592022010120 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592022010121 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 592022010122 NodB motif; other site 592022010123 active site 592022010124 catalytic site [active] 592022010125 Spore germination protein; Region: Spore_permease; cl17796 592022010126 S-methylmethionine transporter; Provisional; Region: PRK11387 592022010127 agmatinase; Region: agmatinase; TIGR01230 592022010128 Arginase family; Region: Arginase; cd09989 592022010129 active site 592022010130 Mn binding site [ion binding]; other site 592022010131 oligomer interface [polypeptide binding]; other site 592022010132 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 592022010133 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592022010134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592022010135 TPR motif; other site 592022010136 binding surface 592022010137 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 592022010138 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 592022010139 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 592022010140 TrkA-N domain; Region: TrkA_N; pfam02254 592022010141 TrkA-C domain; Region: TrkA_C; pfam02080 592022010142 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 592022010143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022010144 putative DNA binding site [nucleotide binding]; other site 592022010145 putative Zn2+ binding site [ion binding]; other site 592022010146 AsnC family; Region: AsnC_trans_reg; pfam01037 592022010147 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 592022010148 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592022010149 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592022010150 protein binding site [polypeptide binding]; other site 592022010151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022010152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022010153 active site 592022010154 phosphorylation site [posttranslational modification] 592022010155 intermolecular recognition site; other site 592022010156 dimerization interface [polypeptide binding]; other site 592022010157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022010158 DNA binding site [nucleotide binding] 592022010159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022010160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022010161 dimerization interface [polypeptide binding]; other site 592022010162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022010163 dimer interface [polypeptide binding]; other site 592022010164 phosphorylation site [posttranslational modification] 592022010165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010166 ATP binding site [chemical binding]; other site 592022010167 Mg2+ binding site [ion binding]; other site 592022010168 G-X-G motif; other site 592022010169 D-cysteine desulfhydrase; Validated; Region: PRK03910 592022010170 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 592022010171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022010172 catalytic residue [active] 592022010173 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592022010174 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 592022010175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022010176 DNA-binding site [nucleotide binding]; DNA binding site 592022010177 FCD domain; Region: FCD; pfam07729 592022010178 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 592022010179 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 592022010180 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 592022010181 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 592022010182 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 592022010183 active site 592022010184 Transcriptional regulator [Transcription]; Region: LytR; COG1316 592022010185 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022010186 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 592022010187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022010188 ABC-ATPase subunit interface; other site 592022010189 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 592022010190 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 592022010191 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 592022010192 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 592022010193 Walker A/P-loop; other site 592022010194 ATP binding site [chemical binding]; other site 592022010195 Q-loop/lid; other site 592022010196 ABC transporter signature motif; other site 592022010197 Walker B; other site 592022010198 D-loop; other site 592022010199 H-loop/switch region; other site 592022010200 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 592022010201 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592022010202 iron-sulfur cluster [ion binding]; other site 592022010203 [2Fe-2S] cluster binding site [ion binding]; other site 592022010204 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592022010205 hydrophobic ligand binding site; other site 592022010206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022010207 putative substrate translocation pore; other site 592022010208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022010209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022010210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022010211 dimer interface [polypeptide binding]; other site 592022010212 phosphorylation site [posttranslational modification] 592022010213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010214 ATP binding site [chemical binding]; other site 592022010215 Mg2+ binding site [ion binding]; other site 592022010216 G-X-G motif; other site 592022010217 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592022010218 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 592022010219 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022010220 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 592022010221 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 592022010222 FMN binding site [chemical binding]; other site 592022010223 substrate binding site [chemical binding]; other site 592022010224 putative catalytic residue [active] 592022010225 catalase, frameshift 592022010226 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 592022010227 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022010228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010229 Coenzyme A binding pocket [chemical binding]; other site 592022010230 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022010231 Transcriptional regulator [Transcription]; Region: LytR; COG1316 592022010232 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 592022010233 Sulfatase; Region: Sulfatase; pfam00884 592022010234 Cupin domain; Region: Cupin_2; cl17218 592022010235 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592022010236 EamA-like transporter family; Region: EamA; pfam00892 592022010237 EamA-like transporter family; Region: EamA; cl17759 592022010238 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592022010239 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 592022010240 putative active site [active] 592022010241 putative FMN binding site [chemical binding]; other site 592022010242 putative substrate binding site [chemical binding]; other site 592022010243 putative catalytic residue [active] 592022010244 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 592022010245 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 592022010246 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 592022010247 Predicted integral membrane protein [Function unknown]; Region: COG5505 592022010248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022010249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022010250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022010251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022010252 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 592022010253 putative dimerization interface [polypeptide binding]; other site 592022010254 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592022010255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022010256 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 592022010257 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592022010258 NAD binding site [chemical binding]; other site 592022010259 substrate binding site [chemical binding]; other site 592022010260 putative active site [active] 592022010261 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 592022010262 MgtC family; Region: MgtC; pfam02308 592022010263 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592022010264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022010265 S-adenosylmethionine binding site [chemical binding]; other site 592022010266 Protein of unknown function (DUF867); Region: DUF867; pfam05908 592022010267 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592022010268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022010269 DNA-binding site [nucleotide binding]; DNA binding site 592022010270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022010271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010272 homodimer interface [polypeptide binding]; other site 592022010273 catalytic residue [active] 592022010274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022010276 Coenzyme A binding pocket [chemical binding]; other site 592022010277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022010279 Coenzyme A binding pocket [chemical binding]; other site 592022010280 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 592022010281 Spore germination protein; Region: Spore_permease; cl17796 592022010282 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592022010283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010284 Coenzyme A binding pocket [chemical binding]; other site 592022010285 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 592022010286 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 592022010287 Ligand binding site; other site 592022010288 Putative Catalytic site; other site 592022010289 DXD motif; other site 592022010290 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 592022010291 Predicted membrane protein [Function unknown]; Region: COG2246 592022010292 GtrA-like protein; Region: GtrA; pfam04138 592022010293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592022010294 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 592022010295 active site 592022010296 metal binding site [ion binding]; metal-binding site 592022010297 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592022010298 protoporphyrinogen oxidase; Provisional; Region: PRK12416 592022010299 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 592022010300 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 592022010301 putative metal binding site [ion binding]; other site 592022010302 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592022010303 active site 592022010304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022010305 EamA-like transporter family; Region: EamA; pfam00892 592022010306 EamA-like transporter family; Region: EamA; pfam00892 592022010307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592022010308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010309 Coenzyme A binding pocket [chemical binding]; other site 592022010310 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592022010311 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 592022010312 amino acid carrier protein; Region: agcS; TIGR00835 592022010313 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 592022010314 Sodium Bile acid symporter family; Region: SBF; cl17470 592022010315 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592022010316 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592022010317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022010318 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 592022010319 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 592022010320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592022010321 Domain of unknown function DUF21; Region: DUF21; pfam01595 592022010322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592022010323 Transporter associated domain; Region: CorC_HlyC; smart01091 592022010324 NAD-dependent deacetylase; Provisional; Region: PRK00481 592022010325 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 592022010326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592022010327 Ligand Binding Site [chemical binding]; other site 592022010328 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 592022010329 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 592022010330 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 592022010331 active site 592022010332 ADP/pyrophosphate binding site [chemical binding]; other site 592022010333 dimerization interface [polypeptide binding]; other site 592022010334 allosteric effector site; other site 592022010335 fructose-1,6-bisphosphate binding site; other site 592022010336 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022010337 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022010338 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022010339 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 592022010340 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 592022010341 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 592022010342 Spore germination protein; Region: Spore_permease; cl17796 592022010343 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 592022010344 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 592022010345 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 592022010346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592022010347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592022010348 Walker A/P-loop; other site 592022010349 ATP binding site [chemical binding]; other site 592022010350 Q-loop/lid; other site 592022010351 ABC transporter signature motif; other site 592022010352 Walker B; other site 592022010353 D-loop; other site 592022010354 H-loop/switch region; other site 592022010355 Predicted transcriptional regulators [Transcription]; Region: COG1725 592022010356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022010357 DNA-binding site [nucleotide binding]; DNA binding site 592022010358 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592022010359 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592022010360 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592022010361 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022010362 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 592022010363 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 592022010364 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 592022010365 active site 592022010366 putative catalytic site [active] 592022010367 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 592022010368 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 592022010369 active site 592022010370 catalytic site [active] 592022010371 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 592022010372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592022010373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022010374 Walker A/P-loop; other site 592022010375 ATP binding site [chemical binding]; other site 592022010376 Q-loop/lid; other site 592022010377 ABC transporter signature motif; other site 592022010378 Walker B; other site 592022010379 D-loop; other site 592022010380 H-loop/switch region; other site 592022010381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 592022010382 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022010383 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 592022010384 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 592022010385 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 592022010386 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 592022010387 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022010388 active site turn [active] 592022010389 phosphorylation site [posttranslational modification] 592022010390 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022010391 transcriptional antiterminator BglG; Provisional; Region: PRK09772 592022010392 CAT RNA binding domain; Region: CAT_RBD; smart01061 592022010393 PRD domain; Region: PRD; pfam00874 592022010394 PRD domain; Region: PRD; pfam00874 592022010395 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 592022010396 HPr interaction site; other site 592022010397 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592022010398 active site 592022010399 phosphorylation site [posttranslational modification] 592022010400 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 592022010401 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022010402 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 592022010403 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592022010404 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592022010405 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592022010406 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 592022010407 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 592022010408 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 592022010409 YodL-like; Region: YodL; pfam14191 592022010410 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 592022010411 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592022010412 active site 592022010413 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 592022010414 SpoOM protein; Region: Spo0M; pfam07070 592022010415 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 592022010416 Catalytic domain of Protein Kinases; Region: PKc; cd00180 592022010417 active site 592022010418 ATP binding site [chemical binding]; other site 592022010419 substrate binding site [chemical binding]; other site 592022010420 activation loop (A-loop); other site 592022010421 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 592022010422 YozD-like protein; Region: YozD; pfam14162 592022010423 hypothetical protein; Provisional; Region: PRK13672 592022010424 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 592022010425 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592022010426 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592022010427 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 592022010428 homodimer interface [polypeptide binding]; other site 592022010429 substrate-cofactor binding pocket; other site 592022010430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010431 catalytic residue [active] 592022010432 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 592022010433 toxin interface [polypeptide binding]; other site 592022010434 Zn binding site [ion binding]; other site 592022010435 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 592022010436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022010437 FeS/SAM binding site; other site 592022010438 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 592022010439 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 592022010440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022010441 Coenzyme A binding pocket [chemical binding]; other site 592022010442 acetylornithine deacetylase; Validated; Region: PRK06915 592022010443 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 592022010444 metal binding site [ion binding]; metal-binding site 592022010445 dimer interface [polypeptide binding]; other site 592022010446 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 592022010447 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 592022010448 hypothetical protein; Provisional; Region: PRK06917 592022010449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022010450 inhibitor-cofactor binding pocket; inhibition site 592022010451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010452 catalytic residue [active] 592022010453 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592022010454 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 592022010455 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 592022010456 hydroxyglutarate oxidase; Provisional; Region: PRK11728 592022010457 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022010458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022010459 putative active site [active] 592022010460 heme pocket [chemical binding]; other site 592022010461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022010462 dimer interface [polypeptide binding]; other site 592022010463 phosphorylation site [posttranslational modification] 592022010464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010465 ATP binding site [chemical binding]; other site 592022010466 Mg2+ binding site [ion binding]; other site 592022010467 G-X-G motif; other site 592022010468 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 592022010469 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 592022010470 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 592022010471 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 592022010472 active site 592022010473 catalytic triad [active] 592022010474 oxyanion hole [active] 592022010475 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 592022010476 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 592022010477 Cu(I) binding site [ion binding]; other site 592022010478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022010479 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022010480 dimerization interface [polypeptide binding]; other site 592022010481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022010482 dimer interface [polypeptide binding]; other site 592022010483 phosphorylation site [posttranslational modification] 592022010484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010485 ATP binding site [chemical binding]; other site 592022010486 Mg2+ binding site [ion binding]; other site 592022010487 G-X-G motif; other site 592022010488 EDD domain protein, DegV family; Region: DegV; TIGR00762 592022010489 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 592022010490 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 592022010491 threonine dehydratase; Validated; Region: PRK08639 592022010492 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 592022010493 tetramer interface [polypeptide binding]; other site 592022010494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010495 catalytic residue [active] 592022010496 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 592022010497 putative Ile/Val binding site [chemical binding]; other site 592022010498 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 592022010499 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 592022010500 folate binding site [chemical binding]; other site 592022010501 NADP+ binding site [chemical binding]; other site 592022010502 thymidylate synthase; Reviewed; Region: thyA; PRK01827 592022010503 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 592022010504 dimerization interface [polypeptide binding]; other site 592022010505 active site 592022010506 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 592022010507 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 592022010508 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 592022010509 putative active site [active] 592022010510 putative substrate binding site [chemical binding]; other site 592022010511 putative cosubstrate binding site; other site 592022010512 catalytic site [active] 592022010513 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 592022010514 IucA / IucC family; Region: IucA_IucC; pfam04183 592022010515 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 592022010516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022010517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022010518 putative substrate translocation pore; other site 592022010519 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 592022010520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022010521 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 592022010522 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 592022010523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022010524 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 592022010525 IucA / IucC family; Region: IucA_IucC; pfam04183 592022010526 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 592022010527 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 592022010528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010529 catalytic residue [active] 592022010530 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 592022010531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022010532 inhibitor-cofactor binding pocket; inhibition site 592022010533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010534 catalytic residue [active] 592022010535 copper homeostasis protein, frameshift 592022010536 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 592022010537 DNA photolyase; Region: DNA_photolyase; pfam00875 592022010538 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 592022010539 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 592022010540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022010541 putative active site [active] 592022010542 heme pocket [chemical binding]; other site 592022010543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022010544 dimer interface [polypeptide binding]; other site 592022010545 phosphorylation site [posttranslational modification] 592022010546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010547 ATP binding site [chemical binding]; other site 592022010548 Mg2+ binding site [ion binding]; other site 592022010549 G-X-G motif; other site 592022010550 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 592022010551 succinic semialdehyde dehydrogenase; Region: PLN02278 592022010552 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 592022010553 tetramerization interface [polypeptide binding]; other site 592022010554 NAD(P) binding site [chemical binding]; other site 592022010555 catalytic residues [active] 592022010556 PAS domain; Region: PAS_9; pfam13426 592022010557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022010558 putative active site [active] 592022010559 heme pocket [chemical binding]; other site 592022010560 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592022010561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022010562 Walker A motif; other site 592022010563 ATP binding site [chemical binding]; other site 592022010564 Walker B motif; other site 592022010565 arginine finger; other site 592022010566 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 592022010567 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 592022010568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022010569 inhibitor-cofactor binding pocket; inhibition site 592022010570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022010571 catalytic residue [active] 592022010572 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 592022010573 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 592022010574 hypothetical protein; Provisional; Region: PRK04164 592022010575 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592022010576 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 592022010577 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 592022010578 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 592022010579 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 592022010580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022010581 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 592022010582 Walker A/P-loop; other site 592022010583 ATP binding site [chemical binding]; other site 592022010584 Q-loop/lid; other site 592022010585 ABC transporter signature motif; other site 592022010586 Walker B; other site 592022010587 D-loop; other site 592022010588 H-loop/switch region; other site 592022010589 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 592022010590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022010591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022010592 Walker A/P-loop; other site 592022010593 ATP binding site [chemical binding]; other site 592022010594 Q-loop/lid; other site 592022010595 ABC transporter signature motif; other site 592022010596 Walker B; other site 592022010597 D-loop; other site 592022010598 H-loop/switch region; other site 592022010599 hypothetical protein; Provisional; Region: PRK01844 592022010600 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 592022010601 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 592022010602 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592022010603 TPP-binding site [chemical binding]; other site 592022010604 dimer interface [polypeptide binding]; other site 592022010605 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592022010606 PYR/PP interface [polypeptide binding]; other site 592022010607 dimer interface [polypeptide binding]; other site 592022010608 TPP binding site [chemical binding]; other site 592022010609 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592022010610 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 592022010611 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 592022010612 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 592022010613 catalytic residues [active] 592022010614 catalytic nucleophile [active] 592022010615 cell division suppressor protein YneA; Provisional; Region: PRK14125 592022010616 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022010617 LexA repressor; Validated; Region: PRK00215 592022010618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022010619 putative DNA binding site [nucleotide binding]; other site 592022010620 putative Zn2+ binding site [ion binding]; other site 592022010621 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592022010622 Catalytic site [active] 592022010623 conserved hypothetical integral membrane protein; Region: TIGR03766 592022010624 GtrA-like protein; Region: GtrA; pfam04138 592022010625 Predicted membrane protein [Function unknown]; Region: COG2246 592022010626 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 592022010627 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 592022010628 Ligand binding site; other site 592022010629 Putative Catalytic site; other site 592022010630 DXD motif; other site 592022010631 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 592022010632 Cation efflux family; Region: Cation_efflux; pfam01545 592022010633 Amino acid permease; Region: AA_permease_2; pfam13520 592022010634 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022010635 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022010636 active site 592022010637 metal binding site [ion binding]; metal-binding site 592022010638 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022010639 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022010640 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022010641 glutamine synthetase, type I; Region: GlnA; TIGR00653 592022010642 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 592022010643 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592022010644 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 592022010645 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022010646 DNA binding residues [nucleotide binding] 592022010647 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 592022010648 Aluminium resistance protein; Region: Alum_res; pfam06838 592022010649 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 592022010650 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 592022010651 HflX GTPase family; Region: HflX; cd01878 592022010652 G1 box; other site 592022010653 GTP/Mg2+ binding site [chemical binding]; other site 592022010654 Switch I region; other site 592022010655 G2 box; other site 592022010656 G3 box; other site 592022010657 Switch II region; other site 592022010658 G4 box; other site 592022010659 G5 box; other site 592022010660 Predicted membrane protein [Function unknown]; Region: COG2860 592022010661 UPF0126 domain; Region: UPF0126; pfam03458 592022010662 UPF0126 domain; Region: UPF0126; pfam03458 592022010663 stage V sporulation protein K; Region: spore_V_K; TIGR02881 592022010664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022010665 Walker A motif; other site 592022010666 ATP binding site [chemical binding]; other site 592022010667 Walker B motif; other site 592022010668 arginine finger; other site 592022010669 bacterial Hfq-like; Region: Hfq; cd01716 592022010670 hexamer interface [polypeptide binding]; other site 592022010671 Sm1 motif; other site 592022010672 RNA binding site [nucleotide binding]; other site 592022010673 Sm2 motif; other site 592022010674 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 592022010675 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 592022010676 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 592022010677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010678 ATP binding site [chemical binding]; other site 592022010679 Mg2+ binding site [ion binding]; other site 592022010680 G-X-G motif; other site 592022010681 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 592022010682 ATP binding site [chemical binding]; other site 592022010683 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 592022010684 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 592022010685 MutS domain I; Region: MutS_I; pfam01624 592022010686 MutS domain II; Region: MutS_II; pfam05188 592022010687 MutS domain III; Region: MutS_III; pfam05192 592022010688 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 592022010689 Walker A/P-loop; other site 592022010690 ATP binding site [chemical binding]; other site 592022010691 Q-loop/lid; other site 592022010692 ABC transporter signature motif; other site 592022010693 Walker B; other site 592022010694 D-loop; other site 592022010695 H-loop/switch region; other site 592022010696 amino acid transporter; Region: 2A0306; TIGR00909 592022010697 Spore germination protein; Region: Spore_permease; cl17796 592022010698 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 592022010699 Outer spore coat protein E (CotE); Region: CotE; pfam10628 592022010700 Predicted membrane protein [Function unknown]; Region: COG4550 592022010701 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 592022010702 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592022010703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022010704 FeS/SAM binding site; other site 592022010705 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 592022010706 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 592022010707 TPP-binding site [chemical binding]; other site 592022010708 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 592022010709 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 592022010710 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 592022010711 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 592022010712 dimer interface [polypeptide binding]; other site 592022010713 PYR/PP interface [polypeptide binding]; other site 592022010714 TPP binding site [chemical binding]; other site 592022010715 substrate binding site [chemical binding]; other site 592022010716 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 592022010717 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 592022010718 active site 592022010719 dimer interface [polypeptide binding]; other site 592022010720 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 592022010721 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 592022010722 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592022010723 putative active site [active] 592022010724 metal binding site [ion binding]; metal-binding site 592022010725 homodimer binding site [polypeptide binding]; other site 592022010726 phosphodiesterase; Provisional; Region: PRK12704 592022010727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022010728 Zn2+ binding site [ion binding]; other site 592022010729 Mg2+ binding site [ion binding]; other site 592022010730 recombinase A; Provisional; Region: recA; PRK09354 592022010731 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 592022010732 hexamer interface [polypeptide binding]; other site 592022010733 Walker A motif; other site 592022010734 ATP binding site [chemical binding]; other site 592022010735 Walker B motif; other site 592022010736 competence damage-inducible protein A; Provisional; Region: PRK00549 592022010737 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 592022010738 putative MPT binding site; other site 592022010739 Competence-damaged protein; Region: CinA; pfam02464 592022010740 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 592022010741 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 592022010742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592022010743 non-specific DNA binding site [nucleotide binding]; other site 592022010744 salt bridge; other site 592022010745 sequence-specific DNA binding site [nucleotide binding]; other site 592022010746 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 592022010747 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 592022010748 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 592022010749 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 592022010750 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 592022010751 classical (c) SDRs; Region: SDR_c; cd05233 592022010752 NAD(P) binding site [chemical binding]; other site 592022010753 active site 592022010754 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592022010755 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592022010756 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592022010757 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592022010758 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592022010759 Vps23 core domain; Region: Vps23_core; pfam09454 592022010760 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592022010761 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 592022010762 TM-ABC transporter signature motif; other site 592022010763 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592022010764 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 592022010765 TM-ABC transporter signature motif; other site 592022010766 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 592022010767 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592022010768 Walker A/P-loop; other site 592022010769 ATP binding site [chemical binding]; other site 592022010770 Q-loop/lid; other site 592022010771 ABC transporter signature motif; other site 592022010772 Walker B; other site 592022010773 D-loop; other site 592022010774 H-loop/switch region; other site 592022010775 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592022010776 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 592022010777 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 592022010778 ligand binding site [chemical binding]; other site 592022010779 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 592022010780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022010781 DNA-binding site [nucleotide binding]; DNA binding site 592022010782 UTRA domain; Region: UTRA; pfam07702 592022010783 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 592022010784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 592022010785 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 592022010786 YlzJ-like protein; Region: YlzJ; pfam14035 592022010787 Clp protease; Region: CLP_protease; pfam00574 592022010788 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 592022010789 active site 592022010790 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 592022010791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022010792 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 592022010793 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 592022010794 dihydrodipicolinate synthase; Region: dapA; TIGR00674 592022010795 dimer interface [polypeptide binding]; other site 592022010796 active site 592022010797 catalytic residue [active] 592022010798 aspartate kinase I; Reviewed; Region: PRK08210 592022010799 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 592022010800 nucleotide binding site [chemical binding]; other site 592022010801 substrate binding site [chemical binding]; other site 592022010802 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 592022010803 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 592022010804 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 592022010805 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592022010806 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 592022010807 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 592022010808 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 592022010809 NAD binding site [chemical binding]; other site 592022010810 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 592022010811 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592022010812 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592022010813 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592022010814 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 592022010815 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 592022010816 NodB motif; other site 592022010817 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 592022010818 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 592022010819 RNase E interface [polypeptide binding]; other site 592022010820 trimer interface [polypeptide binding]; other site 592022010821 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 592022010822 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 592022010823 RNase E interface [polypeptide binding]; other site 592022010824 trimer interface [polypeptide binding]; other site 592022010825 active site 592022010826 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 592022010827 putative nucleic acid binding region [nucleotide binding]; other site 592022010828 G-X-X-G motif; other site 592022010829 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 592022010830 RNA binding site [nucleotide binding]; other site 592022010831 domain interface; other site 592022010832 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 592022010833 16S/18S rRNA binding site [nucleotide binding]; other site 592022010834 S13e-L30e interaction site [polypeptide binding]; other site 592022010835 25S rRNA binding site [nucleotide binding]; other site 592022010836 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 592022010837 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 592022010838 active site 592022010839 Riboflavin kinase; Region: Flavokinase; pfam01687 592022010840 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 592022010841 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 592022010842 RNA binding site [nucleotide binding]; other site 592022010843 active site 592022010844 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 592022010845 Protein of unknown function (DUF503); Region: DUF503; cl00669 592022010846 translation initiation factor IF-2; Region: IF-2; TIGR00487 592022010847 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 592022010848 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 592022010849 G1 box; other site 592022010850 putative GEF interaction site [polypeptide binding]; other site 592022010851 GTP/Mg2+ binding site [chemical binding]; other site 592022010852 Switch I region; other site 592022010853 G2 box; other site 592022010854 G3 box; other site 592022010855 Switch II region; other site 592022010856 G4 box; other site 592022010857 G5 box; other site 592022010858 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 592022010859 Translation-initiation factor 2; Region: IF-2; pfam11987 592022010860 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 592022010861 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 592022010862 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 592022010863 putative RNA binding cleft [nucleotide binding]; other site 592022010864 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 592022010865 NusA N-terminal domain; Region: NusA_N; pfam08529 592022010866 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 592022010867 RNA binding site [nucleotide binding]; other site 592022010868 homodimer interface [polypeptide binding]; other site 592022010869 NusA-like KH domain; Region: KH_5; pfam13184 592022010870 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 592022010871 G-X-X-G motif; other site 592022010872 ribosome maturation protein RimP; Reviewed; Region: PRK00092 592022010873 Sm and related proteins; Region: Sm_like; cl00259 592022010874 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 592022010875 putative oligomer interface [polypeptide binding]; other site 592022010876 putative RNA binding site [nucleotide binding]; other site 592022010877 DNA polymerase III PolC; Validated; Region: polC; PRK00448 592022010878 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 592022010879 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 592022010880 generic binding surface II; other site 592022010881 generic binding surface I; other site 592022010882 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 592022010883 active site 592022010884 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592022010885 active site 592022010886 catalytic site [active] 592022010887 substrate binding site [chemical binding]; other site 592022010888 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 592022010889 prolyl-tRNA synthetase; Provisional; Region: PRK09194 592022010890 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 592022010891 dimer interface [polypeptide binding]; other site 592022010892 motif 1; other site 592022010893 active site 592022010894 motif 2; other site 592022010895 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 592022010896 putative deacylase active site [active] 592022010897 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592022010898 active site 592022010899 motif 3; other site 592022010900 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 592022010901 anticodon binding site; other site 592022010902 RIP metalloprotease RseP; Region: TIGR00054 592022010903 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 592022010904 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 592022010905 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 592022010906 protein binding site [polypeptide binding]; other site 592022010907 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592022010908 putative substrate binding region [chemical binding]; other site 592022010909 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 592022010910 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 592022010911 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 592022010912 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 592022010913 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 592022010914 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 592022010915 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 592022010916 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 592022010917 catalytic residue [active] 592022010918 putative FPP diphosphate binding site; other site 592022010919 putative FPP binding hydrophobic cleft; other site 592022010920 dimer interface [polypeptide binding]; other site 592022010921 putative IPP diphosphate binding site; other site 592022010922 ribosome recycling factor; Reviewed; Region: frr; PRK00083 592022010923 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 592022010924 hinge region; other site 592022010925 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 592022010926 putative nucleotide binding site [chemical binding]; other site 592022010927 uridine monophosphate binding site [chemical binding]; other site 592022010928 homohexameric interface [polypeptide binding]; other site 592022010929 elongation factor Ts; Provisional; Region: tsf; PRK09377 592022010930 UBA/TS-N domain; Region: UBA; pfam00627 592022010931 Elongation factor TS; Region: EF_TS; pfam00889 592022010932 Elongation factor TS; Region: EF_TS; pfam00889 592022010933 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 592022010934 rRNA interaction site [nucleotide binding]; other site 592022010935 S8 interaction site; other site 592022010936 putative laminin-1 binding site; other site 592022010937 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 592022010938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022010939 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592022010940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022010941 DNA binding residues [nucleotide binding] 592022010942 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 592022010943 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 592022010944 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 592022010945 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 592022010946 putative binding surface; other site 592022010947 active site 592022010948 P2 response regulator binding domain; Region: P2; pfam07194 592022010949 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 592022010950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022010951 ATP binding site [chemical binding]; other site 592022010952 Mg2+ binding site [ion binding]; other site 592022010953 G-X-G motif; other site 592022010954 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 592022010955 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 592022010956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022010957 active site 592022010958 phosphorylation site [posttranslational modification] 592022010959 intermolecular recognition site; other site 592022010960 dimerization interface [polypeptide binding]; other site 592022010961 CheB methylesterase; Region: CheB_methylest; pfam01339 592022010962 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 592022010963 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 592022010964 P-loop; other site 592022010965 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 592022010966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592022010967 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 592022010968 FHIPEP family; Region: FHIPEP; pfam00771 592022010969 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 592022010970 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 592022010971 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 592022010972 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 592022010973 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 592022010974 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 592022010975 Response regulator receiver domain; Region: Response_reg; pfam00072 592022010976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022010977 active site 592022010978 phosphorylation site [posttranslational modification] 592022010979 intermolecular recognition site; other site 592022010980 dimerization interface [polypeptide binding]; other site 592022010981 flagellar motor switch protein; Validated; Region: PRK08119 592022010982 CheC-like family; Region: CheC; pfam04509 592022010983 CheC-like family; Region: CheC; pfam04509 592022010984 flagellar motor switch protein FliN; Region: fliN; TIGR02480 592022010985 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 592022010986 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 592022010987 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 592022010988 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 592022010989 Flagellar protein (FlbD); Region: FlbD; pfam06289 592022010990 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 592022010991 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592022010992 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592022010993 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 592022010994 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 592022010995 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 592022010996 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 592022010997 Uncharacterized conserved protein [Function unknown]; Region: COG3334 592022010998 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 592022010999 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 592022011000 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 592022011001 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 592022011002 Walker A motif/ATP binding site; other site 592022011003 Walker B motif; other site 592022011004 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 592022011005 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 592022011006 FliG C-terminal domain; Region: FliG_C; pfam01706 592022011007 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 592022011008 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 592022011009 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 592022011010 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 592022011011 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 592022011012 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592022011013 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592022011014 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 592022011015 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 592022011016 transcriptional repressor CodY; Validated; Region: PRK04158 592022011017 CodY GAF-like domain; Region: CodY; pfam06018 592022011018 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 592022011019 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 592022011020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022011021 Walker A motif; other site 592022011022 ATP binding site [chemical binding]; other site 592022011023 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 592022011024 Walker B motif; other site 592022011025 arginine finger; other site 592022011026 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592022011027 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 592022011028 active site 592022011029 HslU subunit interaction site [polypeptide binding]; other site 592022011030 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 592022011031 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 592022011032 active site 592022011033 Int/Topo IB signature motif; other site 592022011034 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 592022011035 Glucose inhibited division protein A; Region: GIDA; pfam01134 592022011036 DNA topoisomerase I; Validated; Region: PRK05582 592022011037 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 592022011038 active site 592022011039 interdomain interaction site; other site 592022011040 putative metal-binding site [ion binding]; other site 592022011041 nucleotide binding site [chemical binding]; other site 592022011042 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592022011043 domain I; other site 592022011044 DNA binding groove [nucleotide binding] 592022011045 phosphate binding site [ion binding]; other site 592022011046 domain II; other site 592022011047 domain III; other site 592022011048 nucleotide binding site [chemical binding]; other site 592022011049 catalytic site [active] 592022011050 domain IV; other site 592022011051 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592022011052 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592022011053 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 592022011054 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 592022011055 DNA protecting protein DprA; Region: dprA; TIGR00732 592022011056 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 592022011057 CoA binding domain; Region: CoA_binding; pfam02629 592022011058 CoA-ligase; Region: Ligase_CoA; pfam00549 592022011059 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 592022011060 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 592022011061 CoA-ligase; Region: Ligase_CoA; pfam00549 592022011062 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 592022011063 RNA/DNA hybrid binding site [nucleotide binding]; other site 592022011064 active site 592022011065 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 592022011066 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 592022011067 GTP/Mg2+ binding site [chemical binding]; other site 592022011068 G4 box; other site 592022011069 G5 box; other site 592022011070 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 592022011071 G1 box; other site 592022011072 Switch I region; other site 592022011073 G2 box; other site 592022011074 G3 box; other site 592022011075 Switch II region; other site 592022011076 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 592022011077 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592022011078 Catalytic site [active] 592022011079 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 592022011080 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 592022011081 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 592022011082 RimM N-terminal domain; Region: RimM; pfam01782 592022011083 PRC-barrel domain; Region: PRC; pfam05239 592022011084 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 592022011085 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 592022011086 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 592022011087 G-X-X-G motif; other site 592022011088 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 592022011089 signal recognition particle protein; Provisional; Region: PRK10867 592022011090 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 592022011091 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592022011092 P loop; other site 592022011093 GTP binding site [chemical binding]; other site 592022011094 Signal peptide binding domain; Region: SRP_SPB; pfam02978 592022011095 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 592022011096 putative DNA-binding protein; Validated; Region: PRK00118 592022011097 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 592022011098 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 592022011099 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592022011100 P loop; other site 592022011101 GTP binding site [chemical binding]; other site 592022011102 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 592022011103 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 592022011104 Walker A/P-loop; other site 592022011105 ATP binding site [chemical binding]; other site 592022011106 Q-loop/lid; other site 592022011107 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 592022011108 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 592022011109 ABC transporter signature motif; other site 592022011110 Walker B; other site 592022011111 D-loop; other site 592022011112 H-loop/switch region; other site 592022011113 ribonuclease III; Reviewed; Region: rnc; PRK00102 592022011114 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 592022011115 dimerization interface [polypeptide binding]; other site 592022011116 active site 592022011117 metal binding site [ion binding]; metal-binding site 592022011118 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 592022011119 dsRNA binding site [nucleotide binding]; other site 592022011120 acyl carrier protein; Provisional; Region: acpP; PRK00982 592022011121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592022011122 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 592022011123 NAD(P) binding site [chemical binding]; other site 592022011124 homotetramer interface [polypeptide binding]; other site 592022011125 homodimer interface [polypeptide binding]; other site 592022011126 active site 592022011127 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 592022011128 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592022011129 putative phosphate acyltransferase; Provisional; Region: PRK05331 592022011130 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 592022011131 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 592022011132 active site 2 [active] 592022011133 active site 1 [active] 592022011134 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 592022011135 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 592022011136 generic binding surface II; other site 592022011137 ssDNA binding site; other site 592022011138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022011139 ATP binding site [chemical binding]; other site 592022011140 putative Mg++ binding site [ion binding]; other site 592022011141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022011142 nucleotide binding region [chemical binding]; other site 592022011143 ATP-binding site [chemical binding]; other site 592022011144 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 592022011145 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 592022011146 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 592022011147 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 592022011148 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 592022011149 putative L-serine binding site [chemical binding]; other site 592022011150 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 592022011151 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 592022011152 DAK2 domain; Region: Dak2; pfam02734 592022011153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 592022011154 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 592022011155 Thiamine pyrophosphokinase; Region: TPK; cd07995 592022011156 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 592022011157 active site 592022011158 dimerization interface [polypeptide binding]; other site 592022011159 thiamine binding site [chemical binding]; other site 592022011160 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 592022011161 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 592022011162 substrate binding site [chemical binding]; other site 592022011163 hexamer interface [polypeptide binding]; other site 592022011164 metal binding site [ion binding]; metal-binding site 592022011165 GTPase RsgA; Reviewed; Region: PRK00098 592022011166 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 592022011167 RNA binding site [nucleotide binding]; other site 592022011168 homodimer interface [polypeptide binding]; other site 592022011169 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 592022011170 GTPase/Zn-binding domain interface [polypeptide binding]; other site 592022011171 GTP/Mg2+ binding site [chemical binding]; other site 592022011172 G4 box; other site 592022011173 G5 box; other site 592022011174 G1 box; other site 592022011175 Switch I region; other site 592022011176 G2 box; other site 592022011177 G3 box; other site 592022011178 Switch II region; other site 592022011179 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 592022011180 Catalytic domain of Protein Kinases; Region: PKc; cd00180 592022011181 active site 592022011182 ATP binding site [chemical binding]; other site 592022011183 substrate binding site [chemical binding]; other site 592022011184 activation loop (A-loop); other site 592022011185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 592022011186 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 592022011187 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 592022011188 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 592022011189 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 592022011190 Protein phosphatase 2C; Region: PP2C; pfam00481 592022011191 active site 592022011192 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 592022011193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022011194 FeS/SAM binding site; other site 592022011195 16S rRNA methyltransferase B; Provisional; Region: PRK14902 592022011196 NusB family; Region: NusB; pfam01029 592022011197 putative RNA binding site [nucleotide binding]; other site 592022011198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022011199 S-adenosylmethionine binding site [chemical binding]; other site 592022011200 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 592022011201 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 592022011202 putative active site [active] 592022011203 substrate binding site [chemical binding]; other site 592022011204 putative cosubstrate binding site; other site 592022011205 catalytic site [active] 592022011206 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 592022011207 substrate binding site [chemical binding]; other site 592022011208 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 592022011209 active site 592022011210 catalytic residues [active] 592022011211 metal binding site [ion binding]; metal-binding site 592022011212 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 592022011213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022011214 ATP binding site [chemical binding]; other site 592022011215 putative Mg++ binding site [ion binding]; other site 592022011216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022011217 nucleotide binding region [chemical binding]; other site 592022011218 ATP-binding site [chemical binding]; other site 592022011219 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 592022011220 Flavoprotein; Region: Flavoprotein; pfam02441 592022011221 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 592022011222 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 592022011223 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 592022011224 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 592022011225 catalytic site [active] 592022011226 G-X2-G-X-G-K; other site 592022011227 hypothetical protein; Provisional; Region: PRK04323 592022011228 hypothetical protein; Provisional; Region: PRK11820 592022011229 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 592022011230 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 592022011231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 592022011232 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 592022011233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592022011234 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 592022011235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022011236 motif II; other site 592022011237 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 592022011238 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 592022011239 Domain of unknown function (DUF814); Region: DUF814; pfam05670 592022011240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022011241 active site 592022011242 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 592022011243 active site 592022011244 dimer interface [polypeptide binding]; other site 592022011245 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 592022011246 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 592022011247 heterodimer interface [polypeptide binding]; other site 592022011248 active site 592022011249 FMN binding site [chemical binding]; other site 592022011250 homodimer interface [polypeptide binding]; other site 592022011251 substrate binding site [chemical binding]; other site 592022011252 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 592022011253 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 592022011254 FAD binding pocket [chemical binding]; other site 592022011255 FAD binding motif [chemical binding]; other site 592022011256 phosphate binding motif [ion binding]; other site 592022011257 beta-alpha-beta structure motif; other site 592022011258 NAD binding pocket [chemical binding]; other site 592022011259 Iron coordination center [ion binding]; other site 592022011260 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 592022011261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022011262 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592022011263 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 592022011264 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022011265 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592022011266 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 592022011267 IMP binding site; other site 592022011268 dimer interface [polypeptide binding]; other site 592022011269 interdomain contacts; other site 592022011270 partial ornithine binding site; other site 592022011271 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 592022011272 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 592022011273 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 592022011274 catalytic site [active] 592022011275 subunit interface [polypeptide binding]; other site 592022011276 dihydroorotase; Validated; Region: pyrC; PRK09357 592022011277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592022011278 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 592022011279 active site 592022011280 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 592022011281 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592022011282 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592022011283 uracil transporter; Provisional; Region: PRK10720 592022011284 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 592022011285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022011286 active site 592022011287 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 592022011288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022011289 RNA binding surface [nucleotide binding]; other site 592022011290 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592022011291 active site 592022011292 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 592022011293 lipoprotein signal peptidase; Provisional; Region: PRK14787 592022011294 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 592022011295 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 592022011296 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592022011297 active site 592022011298 HIGH motif; other site 592022011299 nucleotide binding site [chemical binding]; other site 592022011300 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592022011301 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 592022011302 active site 592022011303 KMSKS motif; other site 592022011304 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 592022011305 tRNA binding surface [nucleotide binding]; other site 592022011306 anticodon binding site; other site 592022011307 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 592022011308 DivIVA protein; Region: DivIVA; pfam05103 592022011309 DivIVA domain; Region: DivI1A_domain; TIGR03544 592022011310 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 592022011311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022011312 RNA binding surface [nucleotide binding]; other site 592022011313 YGGT family; Region: YGGT; pfam02325 592022011314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 592022011315 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 592022011316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592022011317 catalytic residue [active] 592022011318 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 592022011319 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 592022011320 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 592022011321 sporulation sigma factor SigG; Reviewed; Region: PRK08215 592022011322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022011323 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592022011324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022011325 DNA binding residues [nucleotide binding] 592022011326 sporulation sigma factor SigE; Reviewed; Region: PRK08301 592022011327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022011328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022011329 DNA binding residues [nucleotide binding] 592022011330 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 592022011331 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 592022011332 cell division protein FtsZ; Validated; Region: PRK09330 592022011333 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 592022011334 nucleotide binding site [chemical binding]; other site 592022011335 SulA interaction site; other site 592022011336 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 592022011337 Cell division protein FtsA; Region: FtsA; smart00842 592022011338 Cell division protein FtsA; Region: FtsA; pfam14450 592022011339 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 592022011340 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 592022011341 Cell division protein FtsQ; Region: FtsQ; pfam03799 592022011342 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 592022011343 FAD binding domain; Region: FAD_binding_4; pfam01565 592022011344 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 592022011345 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 592022011346 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 592022011347 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 592022011348 NAD binding site [chemical binding]; other site 592022011349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022011350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592022011351 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 592022011352 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 592022011353 Mg++ binding site [ion binding]; other site 592022011354 putative catalytic motif [active] 592022011355 putative substrate binding site [chemical binding]; other site 592022011356 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 592022011357 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592022011358 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022011359 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592022011360 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 592022011361 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022011362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022011363 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 592022011364 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 592022011365 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022011366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022011367 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 592022011368 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 592022011369 Cell division protein FtsL; Region: FtsL; cl11433 592022011370 MraW methylase family; Region: Methyltransf_5; pfam01795 592022011371 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 592022011372 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 592022011373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 592022011374 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 592022011375 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 592022011376 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592022011377 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592022011378 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 592022011379 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 592022011380 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 592022011381 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592022011382 carboxyltransferase (CT) interaction site; other site 592022011383 biotinylation site [posttranslational modification]; other site 592022011384 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 592022011385 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022011386 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592022011387 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 592022011388 hypothetical protein; Provisional; Region: PRK13688 592022011389 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592022011390 Coenzyme A binding pocket [chemical binding]; other site 592022011391 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 592022011392 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 592022011393 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 592022011394 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022011395 substrate binding site [chemical binding]; other site 592022011396 oxyanion hole (OAH) forming residues; other site 592022011397 trimer interface [polypeptide binding]; other site 592022011398 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 592022011399 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 592022011400 hypothetical protein; Provisional; Region: PRK13670 592022011401 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 592022011402 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 592022011403 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 592022011404 protein binding site [polypeptide binding]; other site 592022011405 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 592022011406 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 592022011407 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 592022011408 active site 592022011409 nucleophile elbow; other site 592022011410 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 592022011411 Nucleoside recognition; Region: Gate; pfam07670 592022011412 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 592022011413 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 592022011414 active site 592022011415 (T/H)XGH motif; other site 592022011416 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 592022011417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022011418 S-adenosylmethionine binding site [chemical binding]; other site 592022011419 hypothetical protein; Provisional; Region: PRK02886 592022011420 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 592022011421 YlbE-like protein; Region: YlbE; pfam14003 592022011422 Putative coat protein; Region: YlbD_coat; pfam14071 592022011423 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 592022011424 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 592022011425 interchain domain interface [polypeptide binding]; other site 592022011426 intrachain domain interface; other site 592022011427 Qi binding site; other site 592022011428 Qo binding site; other site 592022011429 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592022011430 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592022011431 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 592022011432 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 592022011433 interchain domain interface [polypeptide binding]; other site 592022011434 intrachain domain interface; other site 592022011435 heme bH binding site [chemical binding]; other site 592022011436 Qi binding site; other site 592022011437 heme bL binding site [chemical binding]; other site 592022011438 Qo binding site; other site 592022011439 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 592022011440 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 592022011441 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 592022011442 iron-sulfur cluster [ion binding]; other site 592022011443 [2Fe-2S] cluster binding site [ion binding]; other site 592022011444 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 592022011445 hypothetical protein; Provisional; Region: PRK03636 592022011446 UPF0302 domain; Region: UPF0302; pfam08864 592022011447 IDEAL domain; Region: IDEAL; pfam08858 592022011448 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 592022011449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022011450 binding surface 592022011451 TPR motif; other site 592022011452 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 592022011453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022011454 binding surface 592022011455 TPR motif; other site 592022011456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022011457 binding surface 592022011458 TPR repeat; Region: TPR_11; pfam13414 592022011459 TPR motif; other site 592022011460 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 592022011461 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 592022011462 hinge; other site 592022011463 active site 592022011464 prephenate dehydrogenase; Validated; Region: PRK06545 592022011465 prephenate dehydrogenase; Validated; Region: PRK08507 592022011466 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 592022011467 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 592022011468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022011469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022011470 homodimer interface [polypeptide binding]; other site 592022011471 catalytic residue [active] 592022011472 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 592022011473 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 592022011474 substrate binding site [chemical binding]; other site 592022011475 active site 592022011476 catalytic residues [active] 592022011477 heterodimer interface [polypeptide binding]; other site 592022011478 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 592022011479 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 592022011480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022011481 catalytic residue [active] 592022011482 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 592022011483 active site 592022011484 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 592022011485 active site 592022011486 ribulose/triose binding site [chemical binding]; other site 592022011487 phosphate binding site [ion binding]; other site 592022011488 substrate (anthranilate) binding pocket [chemical binding]; other site 592022011489 product (indole) binding pocket [chemical binding]; other site 592022011490 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 592022011491 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592022011492 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592022011493 anthranilate synthase component I; Provisional; Region: PRK13569 592022011494 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592022011495 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592022011496 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 592022011497 active site 592022011498 dimer interface [polypeptide binding]; other site 592022011499 metal binding site [ion binding]; metal-binding site 592022011500 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 592022011501 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 592022011502 Tetramer interface [polypeptide binding]; other site 592022011503 active site 592022011504 FMN-binding site [chemical binding]; other site 592022011505 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 592022011506 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 592022011507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022011508 S-adenosylmethionine binding site [chemical binding]; other site 592022011509 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 592022011510 active site 592022011511 multimer interface [polypeptide binding]; other site 592022011512 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592022011513 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592022011514 substrate binding pocket [chemical binding]; other site 592022011515 chain length determination region; other site 592022011516 substrate-Mg2+ binding site; other site 592022011517 catalytic residues [active] 592022011518 aspartate-rich region 1; other site 592022011519 active site lid residues [active] 592022011520 aspartate-rich region 2; other site 592022011521 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 592022011522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022011523 S-adenosylmethionine binding site [chemical binding]; other site 592022011524 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 592022011525 transcription attenuation protein MtrB; Provisional; Region: PRK13251 592022011526 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 592022011527 homodecamer interface [polypeptide binding]; other site 592022011528 GTP cyclohydrolase I; Provisional; Region: PLN03044 592022011529 active site 592022011530 putative catalytic site residues [active] 592022011531 zinc binding site [ion binding]; other site 592022011532 GTP-CH-I/GFRP interaction surface; other site 592022011533 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592022011534 IHF dimer interface [polypeptide binding]; other site 592022011535 IHF - DNA interface [nucleotide binding]; other site 592022011536 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 592022011537 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 592022011538 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 592022011539 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 592022011540 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 592022011541 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 592022011542 GTP-binding protein Der; Reviewed; Region: PRK00093 592022011543 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 592022011544 G1 box; other site 592022011545 GTP/Mg2+ binding site [chemical binding]; other site 592022011546 Switch I region; other site 592022011547 G2 box; other site 592022011548 Switch II region; other site 592022011549 G3 box; other site 592022011550 G4 box; other site 592022011551 G5 box; other site 592022011552 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 592022011553 G1 box; other site 592022011554 GTP/Mg2+ binding site [chemical binding]; other site 592022011555 Switch I region; other site 592022011556 G2 box; other site 592022011557 G3 box; other site 592022011558 Switch II region; other site 592022011559 G4 box; other site 592022011560 G5 box; other site 592022011561 YpzI-like protein; Region: YpzI; pfam14140 592022011562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022011563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022011564 putative substrate translocation pore; other site 592022011565 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 592022011566 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 592022011567 homotetramer interface [polypeptide binding]; other site 592022011568 FMN binding site [chemical binding]; other site 592022011569 homodimer contacts [polypeptide binding]; other site 592022011570 putative active site [active] 592022011571 putative substrate binding site [chemical binding]; other site 592022011572 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 592022011573 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 592022011574 RNA binding site [nucleotide binding]; other site 592022011575 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 592022011576 RNA binding site [nucleotide binding]; other site 592022011577 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592022011578 RNA binding site [nucleotide binding]; other site 592022011579 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 592022011580 RNA binding site [nucleotide binding]; other site 592022011581 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 592022011582 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592022011583 putative acyl-acceptor binding pocket; other site 592022011584 cytidylate kinase; Provisional; Region: cmk; PRK00023 592022011585 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 592022011586 CMP-binding site; other site 592022011587 The sites determining sugar specificity; other site 592022011588 PilZ domain; Region: PilZ; pfam07238 592022011589 germination protein YpeB; Region: spore_YpeB; TIGR02889 592022011590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022011591 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022011592 Protease prsW family; Region: PrsW-protease; pfam13367 592022011593 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 592022011594 active site 592022011595 homotetramer interface [polypeptide binding]; other site 592022011596 homodimer interface [polypeptide binding]; other site 592022011597 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 592022011598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 592022011599 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022011600 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 592022011601 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592022011602 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 592022011603 NAD(P) binding site [chemical binding]; other site 592022011604 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 592022011605 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592022011606 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 592022011607 DNA binding residues [nucleotide binding] 592022011608 B12 binding domain; Region: B12-binding_2; pfam02607 592022011609 B12 binding domain; Region: B12-binding; pfam02310 592022011610 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 592022011611 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592022011612 putative active site [active] 592022011613 putative metal binding site [ion binding]; other site 592022011614 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 592022011615 CAAX protease self-immunity; Region: Abi; pfam02517 592022011616 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592022011617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022011618 ATP binding site [chemical binding]; other site 592022011619 putative Mg++ binding site [ion binding]; other site 592022011620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022011621 nucleotide binding region [chemical binding]; other site 592022011622 ATP-binding site [chemical binding]; other site 592022011623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 592022011624 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 592022011625 Predicted membrane protein [Function unknown]; Region: COG3601 592022011626 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 592022011627 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 592022011628 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 592022011629 ligand binding site [chemical binding]; other site 592022011630 NAD binding site [chemical binding]; other site 592022011631 dimerization interface [polypeptide binding]; other site 592022011632 catalytic site [active] 592022011633 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 592022011634 putative L-serine binding site [chemical binding]; other site 592022011635 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592022011636 Peptidase family M23; Region: Peptidase_M23; pfam01551 592022011637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022011638 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022011639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 592022011640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022011641 dimerization interface [polypeptide binding]; other site 592022011642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022011643 dimer interface [polypeptide binding]; other site 592022011644 phosphorylation site [posttranslational modification] 592022011645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022011646 ATP binding site [chemical binding]; other site 592022011647 Mg2+ binding site [ion binding]; other site 592022011648 G-X-G motif; other site 592022011649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022011650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022011651 active site 592022011652 phosphorylation site [posttranslational modification] 592022011653 intermolecular recognition site; other site 592022011654 dimerization interface [polypeptide binding]; other site 592022011655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022011656 DNA binding site [nucleotide binding] 592022011657 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 592022011658 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 592022011659 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 592022011660 ResB-like family; Region: ResB; pfam05140 592022011661 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592022011662 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592022011663 catalytic residues [active] 592022011664 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 592022011665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022011666 RNA binding surface [nucleotide binding]; other site 592022011667 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 592022011668 active site 592022011669 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 592022011670 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 592022011671 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 592022011672 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592022011673 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 592022011674 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 592022011675 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 592022011676 Domain of unknown function (DUF309); Region: DUF309; pfam03745 592022011677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022011678 Coenzyme A binding pocket [chemical binding]; other site 592022011679 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 592022011680 active site 592022011681 Predicted secreted protein [Function unknown]; Region: COG4086 592022011682 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 592022011683 diaminopimelate decarboxylase; Region: lysA; TIGR01048 592022011684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 592022011685 active site 592022011686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592022011687 substrate binding site [chemical binding]; other site 592022011688 catalytic residues [active] 592022011689 dimer interface [polypeptide binding]; other site 592022011690 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 592022011691 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 592022011692 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 592022011693 stage V sporulation protein AD; Validated; Region: PRK08304 592022011694 stage V sporulation protein AD; Provisional; Region: PRK12404 592022011695 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 592022011696 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 592022011697 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 592022011698 sporulation sigma factor SigF; Validated; Region: PRK05572 592022011699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022011700 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592022011701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022011702 DNA binding residues [nucleotide binding] 592022011703 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 592022011704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022011705 ATP binding site [chemical binding]; other site 592022011706 Mg2+ binding site [ion binding]; other site 592022011707 G-X-G motif; other site 592022011708 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 592022011709 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592022011710 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 592022011711 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 592022011712 purine nucleoside phosphorylase; Provisional; Region: PRK08202 592022011713 phosphopentomutase; Provisional; Region: PRK05362 592022011714 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 592022011715 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 592022011716 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 592022011717 active site 592022011718 Int/Topo IB signature motif; other site 592022011719 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 592022011720 ferric uptake regulator; Provisional; Region: fur; PRK09462 592022011721 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592022011722 metal binding site 2 [ion binding]; metal-binding site 592022011723 putative DNA binding helix; other site 592022011724 metal binding site 1 [ion binding]; metal-binding site 592022011725 dimer interface [polypeptide binding]; other site 592022011726 structural Zn2+ binding site [ion binding]; other site 592022011727 stage II sporulation protein M; Region: spo_II_M; TIGR02831 592022011728 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592022011729 dimer interface [polypeptide binding]; other site 592022011730 ADP-ribose binding site [chemical binding]; other site 592022011731 active site 592022011732 nudix motif; other site 592022011733 metal binding site [ion binding]; metal-binding site 592022011734 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 592022011735 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592022011736 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592022011737 active site 592022011738 catalytic tetrad [active] 592022011739 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 592022011740 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 592022011741 putative acyltransferase; Provisional; Region: PRK05790 592022011742 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592022011743 dimer interface [polypeptide binding]; other site 592022011744 active site 592022011745 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 592022011746 active site 592022011747 catalytic residues [active] 592022011748 metal binding site [ion binding]; metal-binding site 592022011749 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022011750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592022011751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 592022011752 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 592022011753 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 592022011754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592022011755 NAD(P) binding site [chemical binding]; other site 592022011756 active site 592022011757 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592022011758 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 592022011759 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 592022011760 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592022011761 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 592022011762 active site 592022011763 FMN binding site [chemical binding]; other site 592022011764 substrate binding site [chemical binding]; other site 592022011765 homotetramer interface [polypeptide binding]; other site 592022011766 catalytic residue [active] 592022011767 ribonuclease Z; Region: RNase_Z; TIGR02651 592022011768 aminotransferase; Validated; Region: PRK07678 592022011769 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022011770 inhibitor-cofactor binding pocket; inhibition site 592022011771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022011772 catalytic residue [active] 592022011773 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 592022011774 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 592022011775 tetrameric interface [polypeptide binding]; other site 592022011776 NAD binding site [chemical binding]; other site 592022011777 catalytic residues [active] 592022011778 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 592022011779 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022011780 phenylhydantoinase; Validated; Region: PRK08323 592022011781 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 592022011782 tetramer interface [polypeptide binding]; other site 592022011783 active site 592022011784 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 592022011785 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 592022011786 homodimer interface [polypeptide binding]; other site 592022011787 active site 592022011788 FMN binding site [chemical binding]; other site 592022011789 substrate binding site [chemical binding]; other site 592022011790 4Fe-4S binding domain; Region: Fer4; pfam00037 592022011791 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 592022011792 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592022011793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022011794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022011795 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 592022011796 peptidase T-like protein; Region: PepT-like; TIGR01883 592022011797 metal binding site [ion binding]; metal-binding site 592022011798 putative dimer interface [polypeptide binding]; other site 592022011799 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 592022011800 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 592022011801 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 592022011802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022011803 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 592022011804 dimer interface [polypeptide binding]; other site 592022011805 substrate binding site [chemical binding]; other site 592022011806 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592022011807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 592022011808 Predicted membrane protein [Function unknown]; Region: COG4129 592022011809 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 592022011810 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 592022011811 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592022011812 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592022011813 Walker A/P-loop; other site 592022011814 ATP binding site [chemical binding]; other site 592022011815 Q-loop/lid; other site 592022011816 ABC transporter signature motif; other site 592022011817 Walker B; other site 592022011818 D-loop; other site 592022011819 H-loop/switch region; other site 592022011820 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592022011821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022011822 dimer interface [polypeptide binding]; other site 592022011823 conserved gate region; other site 592022011824 putative PBP binding loops; other site 592022011825 ABC-ATPase subunit interface; other site 592022011826 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022011827 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592022011828 substrate binding pocket [chemical binding]; other site 592022011829 membrane-bound complex binding site; other site 592022011830 hinge residues; other site 592022011831 Disulphide isomerase; Region: Disulph_isomer; pfam06491 592022011832 membrane ATPase/protein kinase; Provisional; Region: PRK09435 592022011833 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 592022011834 Walker A; other site 592022011835 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 592022011836 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 592022011837 active site 592022011838 substrate binding site [chemical binding]; other site 592022011839 coenzyme B12 binding site [chemical binding]; other site 592022011840 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 592022011841 B12 binding site [chemical binding]; other site 592022011842 cobalt ligand [ion binding]; other site 592022011843 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 592022011844 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 592022011845 heterodimer interface [polypeptide binding]; other site 592022011846 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 592022011847 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 592022011848 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592022011849 E3 interaction surface; other site 592022011850 lipoyl attachment site [posttranslational modification]; other site 592022011851 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592022011852 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592022011853 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 592022011854 alpha subunit interface [polypeptide binding]; other site 592022011855 TPP binding site [chemical binding]; other site 592022011856 heterodimer interface [polypeptide binding]; other site 592022011857 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592022011858 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 592022011859 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592022011860 tetramer interface [polypeptide binding]; other site 592022011861 TPP-binding site [chemical binding]; other site 592022011862 heterodimer interface [polypeptide binding]; other site 592022011863 phosphorylation loop region [posttranslational modification] 592022011864 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 592022011865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022011866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022011867 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592022011868 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592022011869 nucleotide binding site [chemical binding]; other site 592022011870 Acetokinase family; Region: Acetate_kinase; cl17229 592022011871 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 592022011872 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592022011873 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 592022011874 NAD binding site [chemical binding]; other site 592022011875 Phe binding site; other site 592022011876 phosphate butyryltransferase; Validated; Region: PRK07742 592022011877 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 592022011878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022011879 putative active site [active] 592022011880 heme pocket [chemical binding]; other site 592022011881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022011882 putative active site [active] 592022011883 heme pocket [chemical binding]; other site 592022011884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022011885 Walker A motif; other site 592022011886 ATP binding site [chemical binding]; other site 592022011887 Walker B motif; other site 592022011888 arginine finger; other site 592022011889 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592022011890 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 592022011891 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 592022011892 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 592022011893 active site 592022011894 catalytic site [active] 592022011895 metal binding site [ion binding]; metal-binding site 592022011896 dimer interface [polypeptide binding]; other site 592022011897 YycC-like protein; Region: YycC; pfam14174 592022011898 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 592022011899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022011900 putative substrate translocation pore; other site 592022011901 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 592022011902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022011903 active site 592022011904 phosphorylation site [posttranslational modification] 592022011905 intermolecular recognition site; other site 592022011906 dimerization interface [polypeptide binding]; other site 592022011907 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 592022011908 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 592022011909 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 592022011910 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 592022011911 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 592022011912 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 592022011913 Walker A/P-loop; other site 592022011914 ATP binding site [chemical binding]; other site 592022011915 Q-loop/lid; other site 592022011916 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 592022011917 ABC transporter signature motif; other site 592022011918 Walker B; other site 592022011919 D-loop; other site 592022011920 H-loop/switch region; other site 592022011921 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 592022011922 arginine repressor; Provisional; Region: PRK04280 592022011923 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 592022011924 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 592022011925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022011926 RNA binding surface [nucleotide binding]; other site 592022011927 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 592022011928 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 592022011929 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 592022011930 TPP-binding site; other site 592022011931 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592022011932 PYR/PP interface [polypeptide binding]; other site 592022011933 dimer interface [polypeptide binding]; other site 592022011934 TPP binding site [chemical binding]; other site 592022011935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592022011936 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592022011937 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592022011938 substrate binding pocket [chemical binding]; other site 592022011939 chain length determination region; other site 592022011940 substrate-Mg2+ binding site; other site 592022011941 catalytic residues [active] 592022011942 aspartate-rich region 1; other site 592022011943 active site lid residues [active] 592022011944 aspartate-rich region 2; other site 592022011945 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 592022011946 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 592022011947 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 592022011948 generic binding surface II; other site 592022011949 generic binding surface I; other site 592022011950 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 592022011951 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 592022011952 putative RNA binding site [nucleotide binding]; other site 592022011953 Asp23 family; Region: Asp23; pfam03780 592022011954 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 592022011955 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592022011956 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592022011957 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592022011958 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 592022011959 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592022011960 carboxyltransferase (CT) interaction site; other site 592022011961 biotinylation site [posttranslational modification]; other site 592022011962 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 592022011963 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 592022011964 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 592022011965 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 592022011966 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 592022011967 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 592022011968 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 592022011969 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 592022011970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022011971 Walker A motif; other site 592022011972 ATP binding site [chemical binding]; other site 592022011973 Walker B motif; other site 592022011974 arginine finger; other site 592022011975 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 592022011976 elongation factor P; Validated; Region: PRK00529 592022011977 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 592022011978 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 592022011979 RNA binding site [nucleotide binding]; other site 592022011980 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 592022011981 RNA binding site [nucleotide binding]; other site 592022011982 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 592022011983 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 592022011984 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 592022011985 active site 592022011986 Dehydroquinase class II; Region: DHquinase_II; pfam01220 592022011987 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 592022011988 trimer interface [polypeptide binding]; other site 592022011989 active site 592022011990 dimer interface [polypeptide binding]; other site 592022011991 Conserved membrane protein YqhR; Region: YqhR; pfam11085 592022011992 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 592022011993 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 592022011994 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 592022011995 active site 592022011996 nucleophile elbow; other site 592022011997 manganese transport transcriptional regulator; Provisional; Region: PRK03902 592022011998 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 592022011999 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 592022012000 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, frameshift 592022012001 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 592022012002 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592022012003 active site residue [active] 592022012004 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 592022012005 tetramer interface [polypeptide binding]; other site 592022012006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022012007 catalytic residue [active] 592022012008 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 592022012009 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 592022012010 tetramer interface [polypeptide binding]; other site 592022012011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022012012 catalytic residue [active] 592022012013 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 592022012014 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 592022012015 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 592022012016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592022012017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022012018 ATP binding site [chemical binding]; other site 592022012019 putative Mg++ binding site [ion binding]; other site 592022012020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022012021 nucleotide binding region [chemical binding]; other site 592022012022 ATP-binding site [chemical binding]; other site 592022012023 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 592022012024 YqzE-like protein; Region: YqzE; pfam14038 592022012025 ComG operon protein 7; Region: ComGG; pfam14173 592022012026 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 592022012027 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 592022012028 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 592022012029 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 592022012030 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 592022012031 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 592022012032 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 592022012033 Type II/IV secretion system protein; Region: T2SE; pfam00437 592022012034 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 592022012035 Walker A motif; other site 592022012036 ATP binding site [chemical binding]; other site 592022012037 Walker B motif; other site 592022012038 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 592022012039 ArsC family; Region: ArsC; pfam03960 592022012040 putative catalytic residues [active] 592022012041 thiol/disulfide switch; other site 592022012042 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 592022012043 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592022012044 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 592022012045 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 592022012046 active site 592022012047 Zn binding site [ion binding]; other site 592022012048 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 592022012049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592022012050 nucleotide binding site [chemical binding]; other site 592022012051 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 592022012052 Rhomboid family; Region: Rhomboid; pfam01694 592022012053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022012054 TPR motif; other site 592022012055 binding surface 592022012056 TPR repeat; Region: TPR_11; pfam13414 592022012057 Integral membrane protein DUF92; Region: DUF92; pfam01940 592022012058 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 592022012059 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 592022012060 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 592022012061 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 592022012062 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 592022012063 active site 592022012064 Substrate binding site; other site 592022012065 Mg++ binding site; other site 592022012066 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 592022012067 putative trimer interface [polypeptide binding]; other site 592022012068 putative CoA binding site [chemical binding]; other site 592022012069 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 592022012070 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 592022012071 active site 592022012072 substrate binding site [chemical binding]; other site 592022012073 metal binding site [ion binding]; metal-binding site 592022012074 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 592022012075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592022012076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592022012077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 592022012078 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 592022012079 PhoU domain; Region: PhoU; pfam01895 592022012080 PhoU domain; Region: PhoU; pfam01895 592022012081 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 592022012082 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 592022012083 Walker A/P-loop; other site 592022012084 ATP binding site [chemical binding]; other site 592022012085 Q-loop/lid; other site 592022012086 ABC transporter signature motif; other site 592022012087 Walker B; other site 592022012088 D-loop; other site 592022012089 H-loop/switch region; other site 592022012090 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022012091 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 592022012092 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022012093 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022012094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022012095 putative substrate translocation pore; other site 592022012096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022012097 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 592022012098 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 592022012099 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 592022012100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 592022012101 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 592022012102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022012103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022012104 putative substrate translocation pore; other site 592022012105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022012106 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 592022012107 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 592022012108 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 592022012109 Uncharacterized conserved protein [Function unknown]; Region: COG5663 592022012110 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592022012111 metal binding site 2 [ion binding]; metal-binding site 592022012112 putative DNA binding helix; other site 592022012113 metal binding site 1 [ion binding]; metal-binding site 592022012114 dimer interface [polypeptide binding]; other site 592022012115 structural Zn2+ binding site [ion binding]; other site 592022012116 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592022012117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022012118 ABC-ATPase subunit interface; other site 592022012119 dimer interface [polypeptide binding]; other site 592022012120 putative PBP binding regions; other site 592022012121 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 592022012122 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 592022012123 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 592022012124 endonuclease IV; Provisional; Region: PRK01060 592022012125 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 592022012126 AP (apurinic/apyrimidinic) site pocket; other site 592022012127 DNA interaction; other site 592022012128 Metal-binding active site; metal-binding site 592022012129 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592022012130 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592022012131 ATP binding site [chemical binding]; other site 592022012132 Mg++ binding site [ion binding]; other site 592022012133 motif III; other site 592022012134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022012135 nucleotide binding region [chemical binding]; other site 592022012136 ATP-binding site [chemical binding]; other site 592022012137 YqfQ-like protein; Region: YqfQ; pfam14181 592022012138 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 592022012139 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 592022012140 Uncharacterized conserved protein [Function unknown]; Region: COG0327 592022012141 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 592022012142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 592022012143 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 592022012144 Uncharacterized conserved protein [Function unknown]; Region: COG0327 592022012145 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 592022012146 Family of unknown function (DUF633); Region: DUF633; pfam04816 592022012147 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592022012148 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592022012149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022012150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592022012151 active site 592022012152 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 592022012153 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 592022012154 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 592022012155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022012156 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592022012157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022012158 DNA binding residues [nucleotide binding] 592022012159 DNA primase; Validated; Region: dnaG; PRK05667 592022012160 CHC2 zinc finger; Region: zf-CHC2; pfam01807 592022012161 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 592022012162 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 592022012163 active site 592022012164 metal binding site [ion binding]; metal-binding site 592022012165 interdomain interaction site; other site 592022012166 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 592022012167 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 592022012168 PEP synthetase regulatory protein; Provisional; Region: PRK05339 592022012169 HTH domain; Region: HTH_11; pfam08279 592022012170 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 592022012171 FOG: CBS domain [General function prediction only]; Region: COG0517 592022012172 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 592022012173 Recombination protein O N terminal; Region: RecO_N; pfam11967 592022012174 Recombination protein O C terminal; Region: RecO_C; pfam02565 592022012175 GTPase Era; Reviewed; Region: era; PRK00089 592022012176 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 592022012177 G1 box; other site 592022012178 GTP/Mg2+ binding site [chemical binding]; other site 592022012179 Switch I region; other site 592022012180 G2 box; other site 592022012181 Switch II region; other site 592022012182 G3 box; other site 592022012183 G4 box; other site 592022012184 G5 box; other site 592022012185 KH domain; Region: KH_2; pfam07650 592022012186 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 592022012187 active site 592022012188 catalytic motif [active] 592022012189 Zn binding site [ion binding]; other site 592022012190 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 592022012191 metal-binding heat shock protein; Provisional; Region: PRK00016 592022012192 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 592022012193 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 592022012194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022012195 Zn2+ binding site [ion binding]; other site 592022012196 Mg2+ binding site [ion binding]; other site 592022012197 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 592022012198 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 592022012199 PhoH-like protein; Region: PhoH; pfam02562 592022012200 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 592022012201 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 592022012202 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 592022012203 hypothetical protein; Provisional; Region: PRK13665 592022012204 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 592022012205 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 592022012206 dimer interface [polypeptide binding]; other site 592022012207 active site residues [active] 592022012208 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 592022012209 Yqey-like protein; Region: YqeY; pfam09424 592022012210 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 592022012211 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 592022012212 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592022012213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022012214 FeS/SAM binding site; other site 592022012215 TRAM domain; Region: TRAM; cl01282 592022012216 RNA methyltransferase, RsmE family; Region: TIGR00046 592022012217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 592022012218 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 592022012219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022012220 S-adenosylmethionine binding site [chemical binding]; other site 592022012221 chaperone protein DnaJ; Provisional; Region: PRK14280 592022012222 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592022012223 HSP70 interaction site [polypeptide binding]; other site 592022012224 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 592022012225 substrate binding site [polypeptide binding]; other site 592022012226 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 592022012227 Zn binding sites [ion binding]; other site 592022012228 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 592022012229 dimer interface [polypeptide binding]; other site 592022012230 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 592022012231 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 592022012232 nucleotide binding site [chemical binding]; other site 592022012233 NEF interaction site [polypeptide binding]; other site 592022012234 SBD interface [polypeptide binding]; other site 592022012235 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592022012236 GrpE; Region: GrpE; pfam01025 592022012237 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 592022012238 dimer interface [polypeptide binding]; other site 592022012239 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 592022012240 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 592022012241 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 592022012242 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 592022012243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022012244 FeS/SAM binding site; other site 592022012245 HemN C-terminal domain; Region: HemN_C; pfam06969 592022012246 GTP-binding protein LepA; Provisional; Region: PRK05433 592022012247 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 592022012248 G1 box; other site 592022012249 putative GEF interaction site [polypeptide binding]; other site 592022012250 GTP/Mg2+ binding site [chemical binding]; other site 592022012251 Switch I region; other site 592022012252 G2 box; other site 592022012253 G3 box; other site 592022012254 Switch II region; other site 592022012255 G4 box; other site 592022012256 G5 box; other site 592022012257 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 592022012258 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 592022012259 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 592022012260 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 592022012261 germination protease; Provisional; Region: PRK02858 592022012262 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 592022012263 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 592022012264 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 592022012265 YqzM-like protein; Region: YqzM; pfam14141 592022012266 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 592022012267 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 592022012268 Competence protein; Region: Competence; pfam03772 592022012269 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022012270 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 592022012271 catalytic motif [active] 592022012272 Zn binding site [ion binding]; other site 592022012273 SLBB domain; Region: SLBB; pfam10531 592022012274 comEA protein; Region: comE; TIGR01259 592022012275 Helix-hairpin-helix motif; Region: HHH; pfam00633 592022012276 late competence protein ComER; Validated; Region: PRK07680 592022012277 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 592022012278 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 592022012279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022012280 S-adenosylmethionine binding site [chemical binding]; other site 592022012281 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 592022012282 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022012283 Zn2+ binding site [ion binding]; other site 592022012284 Mg2+ binding site [ion binding]; other site 592022012285 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 592022012286 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 592022012287 active site 592022012288 (T/H)XGH motif; other site 592022012289 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 592022012290 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 592022012291 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592022012292 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592022012293 shikimate binding site; other site 592022012294 NAD(P) binding site [chemical binding]; other site 592022012295 GTPase YqeH; Provisional; Region: PRK13796 592022012296 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 592022012297 GTP/Mg2+ binding site [chemical binding]; other site 592022012298 G4 box; other site 592022012299 G5 box; other site 592022012300 G1 box; other site 592022012301 Switch I region; other site 592022012302 G2 box; other site 592022012303 G3 box; other site 592022012304 Switch II region; other site 592022012305 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 592022012306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022012307 active site 592022012308 motif I; other site 592022012309 motif II; other site 592022012310 Sporulation inhibitor A; Region: Sda; pfam08970 592022012311 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 592022012312 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 592022012313 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 592022012314 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 592022012315 sporulation sigma factor SigK; Reviewed; Region: PRK05803 592022012316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592022012317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592022012318 DNA binding residues [nucleotide binding] 592022012319 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 592022012320 YrhC-like protein; Region: YrhC; pfam14143 592022012321 cystathionine beta-lyase; Provisional; Region: PRK07671 592022012322 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592022012323 homodimer interface [polypeptide binding]; other site 592022012324 substrate-cofactor binding pocket; other site 592022012325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022012326 catalytic residue [active] 592022012327 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592022012328 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592022012329 dimer interface [polypeptide binding]; other site 592022012330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022012331 catalytic residue [active] 592022012332 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 592022012333 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 592022012334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592022012335 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 592022012336 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 592022012337 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 592022012338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022012339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022012340 Isochorismatase family; Region: Isochorismatase; pfam00857 592022012341 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592022012342 catalytic triad [active] 592022012343 conserved cis-peptide bond; other site 592022012344 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 592022012345 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 592022012346 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592022012347 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 592022012348 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 592022012349 ATP-binding site [chemical binding]; other site 592022012350 Sugar specificity; other site 592022012351 Pyrimidine base specificity; other site 592022012352 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 592022012353 Peptidase family U32; Region: Peptidase_U32; pfam01136 592022012354 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 592022012355 Peptidase family U32; Region: Peptidase_U32; pfam01136 592022012356 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 592022012357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592022012358 YceG-like family; Region: YceG; pfam02618 592022012359 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 592022012360 dimerization interface [polypeptide binding]; other site 592022012361 hypothetical protein; Provisional; Region: PRK13678 592022012362 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 592022012363 hypothetical protein; Provisional; Region: PRK05473 592022012364 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 592022012365 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 592022012366 motif 1; other site 592022012367 active site 592022012368 motif 2; other site 592022012369 motif 3; other site 592022012370 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 592022012371 DHHA1 domain; Region: DHHA1; pfam02272 592022012372 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592022012373 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592022012374 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 592022012375 AAA domain; Region: AAA_30; pfam13604 592022012376 Family description; Region: UvrD_C_2; pfam13538 592022012377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022012378 binding surface 592022012379 TPR motif; other site 592022012380 TPR repeat; Region: TPR_11; pfam13414 592022012381 TPR repeat; Region: TPR_11; pfam13414 592022012382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022012383 binding surface 592022012384 TPR motif; other site 592022012385 TPR repeat; Region: TPR_11; pfam13414 592022012386 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 592022012387 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 592022012388 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 592022012389 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592022012390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022012391 catalytic residue [active] 592022012392 Predicted transcriptional regulator [Transcription]; Region: COG1959 592022012393 Transcriptional regulator; Region: Rrf2; pfam02082 592022012394 recombination factor protein RarA; Reviewed; Region: PRK13342 592022012395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022012396 Walker A motif; other site 592022012397 ATP binding site [chemical binding]; other site 592022012398 Walker B motif; other site 592022012399 arginine finger; other site 592022012400 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 592022012401 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 592022012402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022012403 dimer interface [polypeptide binding]; other site 592022012404 conserved gate region; other site 592022012405 putative PBP binding loops; other site 592022012406 ABC-ATPase subunit interface; other site 592022012407 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 592022012408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022012409 dimer interface [polypeptide binding]; other site 592022012410 conserved gate region; other site 592022012411 putative PBP binding loops; other site 592022012412 ABC-ATPase subunit interface; other site 592022012413 PBP superfamily domain; Region: PBP_like_2; cl17296 592022012414 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 592022012415 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 592022012416 putative ATP binding site [chemical binding]; other site 592022012417 putative substrate interface [chemical binding]; other site 592022012418 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 592022012419 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 592022012420 dimer interface [polypeptide binding]; other site 592022012421 anticodon binding site; other site 592022012422 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 592022012423 homodimer interface [polypeptide binding]; other site 592022012424 motif 1; other site 592022012425 active site 592022012426 motif 2; other site 592022012427 GAD domain; Region: GAD; pfam02938 592022012428 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 592022012429 motif 3; other site 592022012430 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 592022012431 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 592022012432 dimer interface [polypeptide binding]; other site 592022012433 motif 1; other site 592022012434 active site 592022012435 motif 2; other site 592022012436 motif 3; other site 592022012437 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 592022012438 anticodon binding site; other site 592022012439 Bacterial SH3 domain; Region: SH3_3; pfam08239 592022012440 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592022012441 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592022012442 active site 592022012443 metal binding site [ion binding]; metal-binding site 592022012444 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 592022012445 putative active site [active] 592022012446 dimerization interface [polypeptide binding]; other site 592022012447 putative tRNAtyr binding site [nucleotide binding]; other site 592022012448 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 592022012449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022012450 Zn2+ binding site [ion binding]; other site 592022012451 Mg2+ binding site [ion binding]; other site 592022012452 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 592022012453 synthetase active site [active] 592022012454 NTP binding site [chemical binding]; other site 592022012455 metal binding site [ion binding]; metal-binding site 592022012456 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 592022012457 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 592022012458 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022012459 active site 592022012460 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 592022012461 DHH family; Region: DHH; pfam01368 592022012462 DHHA1 domain; Region: DHHA1; pfam02272 592022012463 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 592022012464 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 592022012465 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 592022012466 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 592022012467 Protein export membrane protein; Region: SecD_SecF; pfam02355 592022012468 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 592022012469 stage V sporulation protein B; Region: spore_V_B; TIGR02900 592022012470 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 592022012471 Predicted membrane protein [Function unknown]; Region: COG2323 592022012472 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 592022012473 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 592022012474 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 592022012475 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 592022012476 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 592022012477 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 592022012478 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 592022012479 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 592022012480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022012481 Walker A motif; other site 592022012482 ATP binding site [chemical binding]; other site 592022012483 Walker B motif; other site 592022012484 arginine finger; other site 592022012485 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 592022012486 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 592022012487 RuvA N terminal domain; Region: RuvA_N; pfam01330 592022012488 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 592022012489 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 592022012490 Heat induced stress protein YflT; Region: YflT; pfam11181 592022012491 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 592022012492 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 592022012493 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 592022012494 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022012495 quinolinate synthetase; Provisional; Region: PRK09375 592022012496 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 592022012497 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 592022012498 dimerization interface [polypeptide binding]; other site 592022012499 active site 592022012500 L-aspartate oxidase; Provisional; Region: PRK08071 592022012501 L-aspartate oxidase; Provisional; Region: PRK06175 592022012502 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592022012503 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592022012504 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592022012505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022012506 catalytic residue [active] 592022012507 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 592022012508 HTH domain; Region: HTH_11; pfam08279 592022012509 3H domain; Region: 3H; pfam02829 592022012510 prephenate dehydratase; Provisional; Region: PRK11898 592022012511 Prephenate dehydratase; Region: PDT; pfam00800 592022012512 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 592022012513 putative L-Phe binding site [chemical binding]; other site 592022012514 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 592022012515 hypothetical protein; Provisional; Region: PRK04435 592022012516 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 592022012517 GTPase CgtA; Reviewed; Region: obgE; PRK12297 592022012518 GTP1/OBG; Region: GTP1_OBG; pfam01018 592022012519 Obg GTPase; Region: Obg; cd01898 592022012520 G1 box; other site 592022012521 GTP/Mg2+ binding site [chemical binding]; other site 592022012522 Switch I region; other site 592022012523 G2 box; other site 592022012524 G3 box; other site 592022012525 Switch II region; other site 592022012526 G4 box; other site 592022012527 G5 box; other site 592022012528 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 592022012529 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 592022012530 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 592022012531 hypothetical protein; Provisional; Region: PRK14553 592022012532 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 592022012533 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 592022012534 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 592022012535 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 592022012536 homodimer interface [polypeptide binding]; other site 592022012537 oligonucleotide binding site [chemical binding]; other site 592022012538 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 592022012539 Peptidase family M50; Region: Peptidase_M50; pfam02163 592022012540 active site 592022012541 putative substrate binding region [chemical binding]; other site 592022012542 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592022012543 Peptidase family M23; Region: Peptidase_M23; pfam01551 592022012544 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 592022012545 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 592022012546 Switch I; other site 592022012547 Switch II; other site 592022012548 septum formation inhibitor; Reviewed; Region: minC; PRK00513 592022012549 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 592022012550 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 592022012551 rod shape-determining protein MreC; Provisional; Region: PRK13922 592022012552 rod shape-determining protein MreC; Region: MreC; pfam04085 592022012553 rod shape-determining protein MreB; Provisional; Region: PRK13927 592022012554 MreB and similar proteins; Region: MreB_like; cd10225 592022012555 nucleotide binding site [chemical binding]; other site 592022012556 Mg binding site [ion binding]; other site 592022012557 putative protofilament interaction site [polypeptide binding]; other site 592022012558 RodZ interaction site [polypeptide binding]; other site 592022012559 hypothetical protein; Reviewed; Region: PRK00024 592022012560 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 592022012561 MPN+ (JAMM) motif; other site 592022012562 Zinc-binding site [ion binding]; other site 592022012563 Maf-like protein; Region: Maf; pfam02545 592022012564 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 592022012565 active site 592022012566 dimer interface [polypeptide binding]; other site 592022012567 Sporulation related domain; Region: SPOR; cl10051 592022012568 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 592022012569 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 592022012570 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 592022012571 Predicted membrane protein [Function unknown]; Region: COG2322 592022012572 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 592022012573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022012574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592022012575 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 592022012576 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592022012577 active site 592022012578 HIGH motif; other site 592022012579 nucleotide binding site [chemical binding]; other site 592022012580 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592022012581 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 592022012582 active site 592022012583 KMSKS motif; other site 592022012584 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 592022012585 tRNA binding surface [nucleotide binding]; other site 592022012586 anticodon binding site; other site 592022012587 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 592022012588 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 592022012589 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022012590 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 592022012591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592022012592 inhibitor-cofactor binding pocket; inhibition site 592022012593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022012594 catalytic residue [active] 592022012595 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 592022012596 dimer interface [polypeptide binding]; other site 592022012597 active site 592022012598 Schiff base residues; other site 592022012599 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 592022012600 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 592022012601 active site 592022012602 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 592022012603 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 592022012604 domain interfaces; other site 592022012605 active site 592022012606 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 592022012607 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 592022012608 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 592022012609 tRNA; other site 592022012610 putative tRNA binding site [nucleotide binding]; other site 592022012611 putative NADP binding site [chemical binding]; other site 592022012612 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 592022012613 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 592022012614 G1 box; other site 592022012615 GTP/Mg2+ binding site [chemical binding]; other site 592022012616 Switch I region; other site 592022012617 G2 box; other site 592022012618 G3 box; other site 592022012619 Switch II region; other site 592022012620 G4 box; other site 592022012621 G5 box; other site 592022012622 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 592022012623 Found in ATP-dependent protease La (LON); Region: LON; smart00464 592022012624 Found in ATP-dependent protease La (LON); Region: LON; smart00464 592022012625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022012626 Walker A motif; other site 592022012627 ATP binding site [chemical binding]; other site 592022012628 Walker B motif; other site 592022012629 arginine finger; other site 592022012630 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 592022012631 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 592022012632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022012633 Walker A motif; other site 592022012634 ATP binding site [chemical binding]; other site 592022012635 Walker B motif; other site 592022012636 arginine finger; other site 592022012637 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 592022012638 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 592022012639 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 592022012640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022012641 Walker A motif; other site 592022012642 ATP binding site [chemical binding]; other site 592022012643 Walker B motif; other site 592022012644 arginine finger; other site 592022012645 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592022012646 trigger factor; Provisional; Region: tig; PRK01490 592022012647 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592022012648 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 592022012649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022012650 binding surface 592022012651 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592022012652 TPR motif; other site 592022012653 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 592022012654 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 592022012655 substrate binding site [chemical binding]; other site 592022012656 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 592022012657 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 592022012658 substrate binding site [chemical binding]; other site 592022012659 ligand binding site [chemical binding]; other site 592022012660 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 592022012661 tartrate dehydrogenase; Region: TTC; TIGR02089 592022012662 2-isopropylmalate synthase; Validated; Region: PRK00915 592022012663 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 592022012664 active site 592022012665 catalytic residues [active] 592022012666 metal binding site [ion binding]; metal-binding site 592022012667 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 592022012668 ketol-acid reductoisomerase; Provisional; Region: PRK05479 592022012669 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 592022012670 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 592022012671 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 592022012672 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 592022012673 putative valine binding site [chemical binding]; other site 592022012674 dimer interface [polypeptide binding]; other site 592022012675 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 592022012676 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 592022012677 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592022012678 PYR/PP interface [polypeptide binding]; other site 592022012679 dimer interface [polypeptide binding]; other site 592022012680 TPP binding site [chemical binding]; other site 592022012681 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592022012682 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 592022012683 TPP-binding site [chemical binding]; other site 592022012684 dimer interface [polypeptide binding]; other site 592022012685 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 592022012686 active site 592022012687 metal binding site [ion binding]; metal-binding site 592022012688 homotetramer interface [polypeptide binding]; other site 592022012689 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 592022012690 active site 592022012691 dimerization interface [polypeptide binding]; other site 592022012692 ribonuclease PH; Reviewed; Region: rph; PRK00173 592022012693 Ribonuclease PH; Region: RNase_PH_bact; cd11362 592022012694 hexamer interface [polypeptide binding]; other site 592022012695 active site 592022012696 Spore germination protein [General function prediction only]; Region: COG5401 592022012697 Sporulation and spore germination; Region: Germane; pfam10646 592022012698 Sporulation and spore germination; Region: Germane; pfam10646 592022012699 glutamate racemase; Provisional; Region: PRK00865 592022012700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022012701 MarR family; Region: MarR; pfam01047 592022012702 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 592022012703 pentamer interface [polypeptide binding]; other site 592022012704 dodecaamer interface [polypeptide binding]; other site 592022012705 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 592022012706 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 592022012707 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 592022012708 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 592022012709 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 592022012710 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592022012711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592022012712 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 592022012713 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592022012714 active site 592022012715 dimer interface [polypeptide binding]; other site 592022012716 non-prolyl cis peptide bond; other site 592022012717 insertion regions; other site 592022012718 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 592022012719 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022012720 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592022012721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022012722 dimer interface [polypeptide binding]; other site 592022012723 conserved gate region; other site 592022012724 putative PBP binding loops; other site 592022012725 ABC-ATPase subunit interface; other site 592022012726 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592022012727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592022012728 substrate binding pocket [chemical binding]; other site 592022012729 membrane-bound complex binding site; other site 592022012730 hinge residues; other site 592022012731 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592022012732 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592022012733 Walker A/P-loop; other site 592022012734 ATP binding site [chemical binding]; other site 592022012735 Q-loop/lid; other site 592022012736 ABC transporter signature motif; other site 592022012737 Walker B; other site 592022012738 D-loop; other site 592022012739 H-loop/switch region; other site 592022012740 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 592022012741 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 592022012742 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 592022012743 TrkA-C domain; Region: TrkA_C; pfam02080 592022012744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022012745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022012746 DNA binding residues [nucleotide binding] 592022012747 dimerization interface [polypeptide binding]; other site 592022012748 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592022012749 active site 592022012750 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 592022012751 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 592022012752 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 592022012753 L-aspartate oxidase; Provisional; Region: PRK06175 592022012754 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592022012755 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 592022012756 putative Iron-sulfur protein interface [polypeptide binding]; other site 592022012757 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 592022012758 proximal heme binding site [chemical binding]; other site 592022012759 distal heme binding site [chemical binding]; other site 592022012760 putative dimer interface [polypeptide binding]; other site 592022012761 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 592022012762 aspartate kinase; Reviewed; Region: PRK06635 592022012763 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 592022012764 putative nucleotide binding site [chemical binding]; other site 592022012765 putative catalytic residues [active] 592022012766 putative Mg ion binding site [ion binding]; other site 592022012767 putative aspartate binding site [chemical binding]; other site 592022012768 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 592022012769 putative allosteric regulatory site; other site 592022012770 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 592022012771 putative allosteric regulatory residue; other site 592022012772 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 592022012773 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 592022012774 GIY-YIG motif/motif A; other site 592022012775 active site 592022012776 catalytic site [active] 592022012777 putative DNA binding site [nucleotide binding]; other site 592022012778 metal binding site [ion binding]; metal-binding site 592022012779 UvrB/uvrC motif; Region: UVR; pfam02151 592022012780 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 592022012781 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592022012782 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592022012783 catalytic residues [active] 592022012784 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 592022012785 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 592022012786 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 592022012787 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 592022012788 Ligand binding site [chemical binding]; other site 592022012789 Electron transfer flavoprotein domain; Region: ETF; pfam01012 592022012790 enoyl-CoA hydratase; Provisional; Region: PRK07658 592022012791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022012792 substrate binding site [chemical binding]; other site 592022012793 oxyanion hole (OAH) forming residues; other site 592022012794 trimer interface [polypeptide binding]; other site 592022012795 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 592022012796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022012797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022012798 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 592022012799 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 592022012800 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 592022012801 acyl-activating enzyme (AAE) consensus motif; other site 592022012802 putative AMP binding site [chemical binding]; other site 592022012803 putative active site [active] 592022012804 putative CoA binding site [chemical binding]; other site 592022012805 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 592022012806 substrate binding site [chemical binding]; other site 592022012807 THF binding site; other site 592022012808 zinc-binding site [ion binding]; other site 592022012809 Predicted membrane protein [Function unknown]; Region: COG3766 592022012810 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 592022012811 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 592022012812 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 592022012813 MutS domain III; Region: MutS_III; pfam05192 592022012814 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 592022012815 Walker A/P-loop; other site 592022012816 ATP binding site [chemical binding]; other site 592022012817 Q-loop/lid; other site 592022012818 ABC transporter signature motif; other site 592022012819 Walker B; other site 592022012820 D-loop; other site 592022012821 H-loop/switch region; other site 592022012822 Smr domain; Region: Smr; pfam01713 592022012823 hypothetical protein; Provisional; Region: PRK08609 592022012824 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 592022012825 active site 592022012826 primer binding site [nucleotide binding]; other site 592022012827 NTP binding site [chemical binding]; other site 592022012828 metal binding triad [ion binding]; metal-binding site 592022012829 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 592022012830 active site 592022012831 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 592022012832 Colicin V production protein; Region: Colicin_V; pfam02674 592022012833 cell division protein ZapA; Provisional; Region: PRK14126 592022012834 ribonuclease HIII; Provisional; Region: PRK00996 592022012835 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 592022012836 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 592022012837 RNA/DNA hybrid binding site [nucleotide binding]; other site 592022012838 active site 592022012839 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 592022012840 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 592022012841 putative tRNA-binding site [nucleotide binding]; other site 592022012842 B3/4 domain; Region: B3_4; pfam03483 592022012843 tRNA synthetase B5 domain; Region: B5; smart00874 592022012844 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 592022012845 dimer interface [polypeptide binding]; other site 592022012846 motif 1; other site 592022012847 motif 3; other site 592022012848 motif 2; other site 592022012849 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 592022012850 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 592022012851 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 592022012852 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 592022012853 dimer interface [polypeptide binding]; other site 592022012854 motif 1; other site 592022012855 active site 592022012856 motif 2; other site 592022012857 motif 3; other site 592022012858 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 592022012859 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 592022012860 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592022012861 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 592022012862 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 592022012863 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 592022012864 oligomer interface [polypeptide binding]; other site 592022012865 active site 592022012866 metal binding site [ion binding]; metal-binding site 592022012867 dUTPase; Region: dUTPase_2; pfam08761 592022012868 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 592022012869 active site 592022012870 homodimer interface [polypeptide binding]; other site 592022012871 metal binding site [ion binding]; metal-binding site 592022012872 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 592022012873 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 592022012874 23S rRNA binding site [nucleotide binding]; other site 592022012875 L21 binding site [polypeptide binding]; other site 592022012876 L13 binding site [polypeptide binding]; other site 592022012877 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 592022012878 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 592022012879 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 592022012880 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 592022012881 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 592022012882 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 592022012883 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 592022012884 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 592022012885 active site 592022012886 dimer interface [polypeptide binding]; other site 592022012887 motif 1; other site 592022012888 motif 2; other site 592022012889 motif 3; other site 592022012890 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 592022012891 anticodon binding site; other site 592022012892 YtxC-like family; Region: YtxC; pfam08812 592022012893 primosomal protein DnaI; Reviewed; Region: PRK08939 592022012894 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 592022012895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022012896 Walker A motif; other site 592022012897 ATP binding site [chemical binding]; other site 592022012898 Walker B motif; other site 592022012899 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 592022012900 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 592022012901 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 592022012902 ATP cone domain; Region: ATP-cone; pfam03477 592022012903 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 592022012904 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 592022012905 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 592022012906 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592022012907 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 592022012908 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 592022012909 CoA-binding site [chemical binding]; other site 592022012910 ATP-binding [chemical binding]; other site 592022012911 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 592022012912 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 592022012913 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 592022012914 DNA binding site [nucleotide binding] 592022012915 catalytic residue [active] 592022012916 H2TH interface [polypeptide binding]; other site 592022012917 putative catalytic residues [active] 592022012918 turnover-facilitating residue; other site 592022012919 intercalation triad [nucleotide binding]; other site 592022012920 8OG recognition residue [nucleotide binding]; other site 592022012921 putative reading head residues; other site 592022012922 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 592022012923 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 592022012924 DNA polymerase I; Provisional; Region: PRK05755 592022012925 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 592022012926 active site 592022012927 metal binding site 1 [ion binding]; metal-binding site 592022012928 putative 5' ssDNA interaction site; other site 592022012929 metal binding site 3; metal-binding site 592022012930 metal binding site 2 [ion binding]; metal-binding site 592022012931 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 592022012932 putative DNA binding site [nucleotide binding]; other site 592022012933 putative metal binding site [ion binding]; other site 592022012934 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 592022012935 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 592022012936 active site 592022012937 DNA binding site [nucleotide binding] 592022012938 catalytic site [active] 592022012939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022012940 dimerization interface [polypeptide binding]; other site 592022012941 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 592022012942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022012943 putative active site [active] 592022012944 heme pocket [chemical binding]; other site 592022012945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022012946 dimer interface [polypeptide binding]; other site 592022012947 phosphorylation site [posttranslational modification] 592022012948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022012949 ATP binding site [chemical binding]; other site 592022012950 Mg2+ binding site [ion binding]; other site 592022012951 G-X-G motif; other site 592022012952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022012953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022012954 active site 592022012955 phosphorylation site [posttranslational modification] 592022012956 intermolecular recognition site; other site 592022012957 dimerization interface [polypeptide binding]; other site 592022012958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022012959 DNA binding site [nucleotide binding] 592022012960 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 592022012961 active site 2 [active] 592022012962 active site 1 [active] 592022012963 malate dehydrogenase; Reviewed; Region: PRK06223 592022012964 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 592022012965 NAD(P) binding site [chemical binding]; other site 592022012966 dimer interface [polypeptide binding]; other site 592022012967 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022012968 substrate binding site [chemical binding]; other site 592022012969 isocitrate dehydrogenase; Reviewed; Region: PRK07006 592022012970 isocitrate dehydrogenase; Validated; Region: PRK06451 592022012971 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 592022012972 dimer interface [polypeptide binding]; other site 592022012973 Citrate synthase; Region: Citrate_synt; pfam00285 592022012974 active site 592022012975 citrylCoA binding site [chemical binding]; other site 592022012976 oxalacetate/citrate binding site [chemical binding]; other site 592022012977 coenzyme A binding site [chemical binding]; other site 592022012978 catalytic triad [active] 592022012979 Protein of unknown function (DUF441); Region: DUF441; pfam04284 592022012980 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 592022012981 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592022012982 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 592022012983 pyruvate kinase; Provisional; Region: PRK06354 592022012984 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 592022012985 domain interfaces; other site 592022012986 active site 592022012987 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 592022012988 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 592022012989 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 592022012990 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 592022012991 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 592022012992 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592022012993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022012994 DNA-binding site [nucleotide binding]; DNA binding site 592022012995 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 592022012996 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592022012997 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 592022012998 putative NAD(P) binding site [chemical binding]; other site 592022012999 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 592022013000 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 592022013001 active site 592022013002 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 592022013003 generic binding surface I; other site 592022013004 generic binding surface II; other site 592022013005 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 592022013006 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 592022013007 DHH family; Region: DHH; pfam01368 592022013008 DHHA1 domain; Region: DHHA1; pfam02272 592022013009 YtpI-like protein; Region: YtpI; pfam14007 592022013010 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 592022013011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592022013012 DNA-binding site [nucleotide binding]; DNA binding site 592022013013 DRTGG domain; Region: DRTGG; pfam07085 592022013014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 592022013015 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 592022013016 active site 2 [active] 592022013017 active site 1 [active] 592022013018 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592022013019 metal-dependent hydrolase; Provisional; Region: PRK00685 592022013020 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 592022013021 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 592022013022 hexamer interface [polypeptide binding]; other site 592022013023 ligand binding site [chemical binding]; other site 592022013024 putative active site [active] 592022013025 NAD(P) binding site [chemical binding]; other site 592022013026 argininosuccinate lyase; Provisional; Region: PRK00855 592022013027 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 592022013028 active sites [active] 592022013029 tetramer interface [polypeptide binding]; other site 592022013030 argininosuccinate synthase; Provisional; Region: PRK13820 592022013031 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 592022013032 ANP binding site [chemical binding]; other site 592022013033 Substrate Binding Site II [chemical binding]; other site 592022013034 Substrate Binding Site I [chemical binding]; other site 592022013035 EcsC protein family; Region: EcsC; pfam12787 592022013036 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 592022013037 propionate/acetate kinase; Provisional; Region: PRK12379 592022013038 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 592022013039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022013040 S-adenosylmethionine binding site [chemical binding]; other site 592022013041 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 592022013042 dimer interface [polypeptide binding]; other site 592022013043 catalytic triad [active] 592022013044 peroxidatic and resolving cysteines [active] 592022013045 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 592022013046 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 592022013047 RDD family; Region: RDD; pfam06271 592022013048 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 592022013049 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 592022013050 tandem repeat interface [polypeptide binding]; other site 592022013051 oligomer interface [polypeptide binding]; other site 592022013052 active site residues [active] 592022013053 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 592022013054 ATP-NAD kinase; Region: NAD_kinase; pfam01513 592022013055 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 592022013056 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 592022013057 active site 592022013058 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 592022013059 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 592022013060 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 592022013061 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 592022013062 Ligand Binding Site [chemical binding]; other site 592022013063 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 592022013064 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592022013065 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022013066 catalytic residue [active] 592022013067 septation ring formation regulator EzrA; Provisional; Region: PRK04778 592022013068 histidinol-phosphatase; Reviewed; Region: PRK08123 592022013069 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 592022013070 active site 592022013071 dimer interface [polypeptide binding]; other site 592022013072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022013073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022013074 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 592022013075 GAF domain; Region: GAF_2; pfam13185 592022013076 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 592022013077 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 592022013078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022013079 RNA binding surface [nucleotide binding]; other site 592022013080 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 592022013081 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 592022013082 active site 592022013083 HIGH motif; other site 592022013084 dimer interface [polypeptide binding]; other site 592022013085 KMSKS motif; other site 592022013086 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022013087 RNA binding surface [nucleotide binding]; other site 592022013088 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 592022013089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592022013090 acyl-activating enzyme (AAE) consensus motif; other site 592022013091 active site 592022013092 AMP binding site [chemical binding]; other site 592022013093 CoA binding site [chemical binding]; other site 592022013094 FOG: CBS domain [General function prediction only]; Region: COG0517 592022013095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 592022013096 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 592022013097 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 592022013098 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 592022013099 active site 592022013100 Zn binding site [ion binding]; other site 592022013101 flagellar motor protein MotS; Reviewed; Region: PRK06925 592022013102 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592022013103 ligand binding site [chemical binding]; other site 592022013104 flagellar motor protein MotP; Reviewed; Region: PRK06926 592022013105 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 592022013106 catabolite control protein A; Region: ccpA; TIGR01481 592022013107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022013108 DNA binding site [nucleotide binding] 592022013109 domain linker motif; other site 592022013110 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 592022013111 dimerization interface [polypeptide binding]; other site 592022013112 effector binding site; other site 592022013113 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 592022013114 Chorismate mutase type II; Region: CM_2; cl00693 592022013115 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 592022013116 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 592022013117 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 592022013118 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 592022013119 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 592022013120 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 592022013121 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592022013122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592022013123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592022013124 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 592022013125 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592022013126 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 592022013127 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 592022013128 putative tRNA-binding site [nucleotide binding]; other site 592022013129 hypothetical protein; Provisional; Region: PRK13668 592022013130 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592022013131 catalytic residues [active] 592022013132 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 592022013133 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 592022013134 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 592022013135 oligomer interface [polypeptide binding]; other site 592022013136 active site 592022013137 metal binding site [ion binding]; metal-binding site 592022013138 Predicted small secreted protein [Function unknown]; Region: COG5584 592022013139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592022013140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022013141 S-adenosylmethionine binding site [chemical binding]; other site 592022013142 YtzH-like protein; Region: YtzH; pfam14165 592022013143 Phosphotransferase enzyme family; Region: APH; pfam01636 592022013144 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 592022013145 active site 592022013146 substrate binding site [chemical binding]; other site 592022013147 ATP binding site [chemical binding]; other site 592022013148 pullulanase, type I; Region: pulA_typeI; TIGR02104 592022013149 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 592022013150 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 592022013151 Ca binding site [ion binding]; other site 592022013152 active site 592022013153 catalytic site [active] 592022013154 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 592022013155 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 592022013156 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 592022013157 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 592022013158 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592022013159 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592022013160 dimer interface [polypeptide binding]; other site 592022013161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022013162 catalytic residue [active] 592022013163 dipeptidase PepV; Reviewed; Region: PRK07318 592022013164 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 592022013165 active site 592022013166 metal binding site [ion binding]; metal-binding site 592022013167 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 592022013168 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 592022013169 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592022013170 RNA binding surface [nucleotide binding]; other site 592022013171 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 592022013172 active site 592022013173 uracil binding [chemical binding]; other site 592022013174 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592022013175 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 592022013176 HI0933-like protein; Region: HI0933_like; pfam03486 592022013177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022013178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592022013179 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 592022013180 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592022013181 active site residue [active] 592022013182 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 592022013183 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 592022013184 HIGH motif; other site 592022013185 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592022013186 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 592022013187 active site 592022013188 KMSKS motif; other site 592022013189 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 592022013190 tRNA binding surface [nucleotide binding]; other site 592022013191 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 592022013192 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592022013193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022013194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592022013195 putative substrate translocation pore; other site 592022013196 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 592022013197 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 592022013198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592022013199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022013200 S-adenosylmethionine binding site [chemical binding]; other site 592022013201 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 592022013202 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022013203 Plasmodium subtelomeric family (PST-A); Region: PST-A; TIGR01607 592022013204 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 592022013205 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 592022013206 trimer interface [polypeptide binding]; other site 592022013207 putative metal binding site [ion binding]; other site 592022013208 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592022013209 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592022013210 active site 592022013211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592022013212 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 592022013213 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 592022013214 S-adenosylmethionine synthetase; Validated; Region: PRK05250 592022013215 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 592022013216 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 592022013217 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 592022013218 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 592022013219 active site 592022013220 substrate-binding site [chemical binding]; other site 592022013221 metal-binding site [ion binding] 592022013222 ATP binding site [chemical binding]; other site 592022013223 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 592022013224 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592022013225 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592022013226 NMT1-like family; Region: NMT1_2; pfam13379 592022013227 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592022013228 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592022013229 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592022013230 Walker A/P-loop; other site 592022013231 ATP binding site [chemical binding]; other site 592022013232 Q-loop/lid; other site 592022013233 ABC transporter signature motif; other site 592022013234 Walker B; other site 592022013235 D-loop; other site 592022013236 H-loop/switch region; other site 592022013237 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592022013238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022013239 dimer interface [polypeptide binding]; other site 592022013240 conserved gate region; other site 592022013241 putative PBP binding loops; other site 592022013242 ABC-ATPase subunit interface; other site 592022013243 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 592022013244 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 592022013245 nudix motif; other site 592022013246 Holin family; Region: Phage_holin_4; cl01989 592022013247 Ferritin-like domain; Region: Ferritin; pfam00210 592022013248 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 592022013249 dimerization interface [polypeptide binding]; other site 592022013250 DPS ferroxidase diiron center [ion binding]; other site 592022013251 ion pore; other site 592022013252 S-ribosylhomocysteinase; Provisional; Region: PRK02260 592022013253 Haemolytic domain; Region: Haemolytic; pfam01809 592022013254 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 592022013255 active site clefts [active] 592022013256 zinc binding site [ion binding]; other site 592022013257 dimer interface [polypeptide binding]; other site 592022013258 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 592022013259 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 592022013260 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 592022013261 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 592022013262 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 592022013263 metal binding site [ion binding]; metal-binding site 592022013264 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 592022013265 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 592022013266 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 592022013267 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022013268 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 592022013269 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 592022013270 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 592022013271 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 592022013272 dimer interface [polypeptide binding]; other site 592022013273 putative radical transfer pathway; other site 592022013274 diiron center [ion binding]; other site 592022013275 tyrosyl radical; other site 592022013276 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 592022013277 Class I ribonucleotide reductase; Region: RNR_I; cd01679 592022013278 active site 592022013279 dimer interface [polypeptide binding]; other site 592022013280 catalytic residues [active] 592022013281 effector binding site; other site 592022013282 R2 peptide binding site; other site 592022013283 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 592022013284 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 592022013285 active site 592022013286 octamer interface [polypeptide binding]; other site 592022013287 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 592022013288 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 592022013289 acyl-activating enzyme (AAE) consensus motif; other site 592022013290 putative AMP binding site [chemical binding]; other site 592022013291 putative active site [active] 592022013292 putative CoA binding site [chemical binding]; other site 592022013293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022013294 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 592022013295 substrate binding site [chemical binding]; other site 592022013296 oxyanion hole (OAH) forming residues; other site 592022013297 trimer interface [polypeptide binding]; other site 592022013298 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 592022013299 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592022013300 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 592022013301 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 592022013302 dimer interface [polypeptide binding]; other site 592022013303 tetramer interface [polypeptide binding]; other site 592022013304 PYR/PP interface [polypeptide binding]; other site 592022013305 TPP binding site [chemical binding]; other site 592022013306 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 592022013307 TPP-binding site; other site 592022013308 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 592022013309 isochorismate synthases; Region: isochor_syn; TIGR00543 592022013310 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 592022013311 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 592022013312 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 592022013313 homodimer interface [polypeptide binding]; other site 592022013314 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 592022013315 active site pocket [active] 592022013316 glycogen synthase; Provisional; Region: glgA; PRK00654 592022013317 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 592022013318 ADP-binding pocket [chemical binding]; other site 592022013319 homodimer interface [polypeptide binding]; other site 592022013320 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 592022013321 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 592022013322 ligand binding site; other site 592022013323 oligomer interface; other site 592022013324 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 592022013325 dimer interface [polypeptide binding]; other site 592022013326 N-terminal domain interface [polypeptide binding]; other site 592022013327 sulfate 1 binding site; other site 592022013328 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 592022013329 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 592022013330 ligand binding site; other site 592022013331 oligomer interface; other site 592022013332 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 592022013333 dimer interface [polypeptide binding]; other site 592022013334 N-terminal domain interface [polypeptide binding]; other site 592022013335 sulfate 1 binding site; other site 592022013336 glycogen branching enzyme; Provisional; Region: PRK12313 592022013337 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 592022013338 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 592022013339 active site 592022013340 catalytic site [active] 592022013341 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 592022013342 AMP-binding domain protein; Validated; Region: PRK08315 592022013343 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592022013344 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 592022013345 acyl-activating enzyme (AAE) consensus motif; other site 592022013346 putative AMP binding site [chemical binding]; other site 592022013347 putative active site [active] 592022013348 putative CoA binding site [chemical binding]; other site 592022013349 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 592022013350 MgtC family; Region: MgtC; pfam02308 592022013351 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 592022013352 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 592022013353 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 592022013354 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 592022013355 putative active site [active] 592022013356 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 592022013357 putative active site [active] 592022013358 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 592022013359 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 592022013360 active site 592022013361 SAM binding site [chemical binding]; other site 592022013362 homodimer interface [polypeptide binding]; other site 592022013363 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 592022013364 AAA domain; Region: AAA_18; pfam13238 592022013365 ligand-binding site [chemical binding]; other site 592022013366 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 592022013367 ATP-sulfurylase; Region: ATPS; cd00517 592022013368 active site 592022013369 HXXH motif; other site 592022013370 flexible loop; other site 592022013371 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 592022013372 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 592022013373 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 592022013374 Active Sites [active] 592022013375 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 592022013376 Uncharacterized conserved protein [Function unknown]; Region: COG1624 592022013377 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 592022013378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592022013379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592022013380 active site 592022013381 metal binding site [ion binding]; metal-binding site 592022013382 Ion channel; Region: Ion_trans_2; pfam07885 592022013383 TrkA-N domain; Region: TrkA_N; pfam02254 592022013384 YugN-like family; Region: YugN; pfam08868 592022013385 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 592022013386 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 592022013387 active site 592022013388 dimer interface [polypeptide binding]; other site 592022013389 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 592022013390 dimer interface [polypeptide binding]; other site 592022013391 active site 592022013392 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 592022013393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592022013394 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 592022013395 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 592022013396 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 592022013397 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 592022013398 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592022013399 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 592022013400 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 592022013401 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 592022013402 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 592022013403 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 592022013404 dimer interface [polypeptide binding]; other site 592022013405 active site 592022013406 metal binding site [ion binding]; metal-binding site 592022013407 Domain of unknown function (DUF378); Region: DUF378; pfam04070 592022013408 general stress protein 13; Validated; Region: PRK08059 592022013409 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 592022013410 RNA binding site [nucleotide binding]; other site 592022013411 hypothetical protein; Validated; Region: PRK07682 592022013412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022013413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022013414 homodimer interface [polypeptide binding]; other site 592022013415 catalytic residue [active] 592022013416 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 592022013417 AsnC family; Region: AsnC_trans_reg; pfam01037 592022013418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592022013419 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 592022013420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592022013421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022013422 homodimer interface [polypeptide binding]; other site 592022013423 catalytic residue [active] 592022013424 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 592022013425 E-class dimer interface [polypeptide binding]; other site 592022013426 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 592022013427 P-class dimer interface [polypeptide binding]; other site 592022013428 active site 592022013429 Cu2+ binding site [ion binding]; other site 592022013430 Zn2+ binding site [ion binding]; other site 592022013431 Kinase associated protein B; Region: KapB; pfam08810 592022013432 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 592022013433 active site 592022013434 catalytic site [active] 592022013435 substrate binding site [chemical binding]; other site 592022013436 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 592022013437 CoenzymeA binding site [chemical binding]; other site 592022013438 subunit interaction site [polypeptide binding]; other site 592022013439 PHB binding site; other site 592022013440 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 592022013441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022013442 Zn2+ binding site [ion binding]; other site 592022013443 Mg2+ binding site [ion binding]; other site 592022013444 Predicted permease [General function prediction only]; Region: COG2056 592022013445 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 592022013446 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 592022013447 multifunctional aminopeptidase A; Provisional; Region: PRK00913 592022013448 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 592022013449 interface (dimer of trimers) [polypeptide binding]; other site 592022013450 Substrate-binding/catalytic site; other site 592022013451 Zn-binding sites [ion binding]; other site 592022013452 Divergent PAP2 family; Region: DUF212; pfam02681 592022013453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 592022013454 Putative membrane protein; Region: YuiB; pfam14068 592022013455 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 592022013456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022013457 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592022013458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022013459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022013460 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 592022013461 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 592022013462 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592022013463 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592022013464 hypothetical protein; Provisional; Region: PRK13669 592022013465 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 592022013466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022013467 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 592022013468 NifU-like domain; Region: NifU; pfam01106 592022013469 homoserine kinase; Provisional; Region: PRK01212 592022013470 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592022013471 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 592022013472 threonine synthase; Reviewed; Region: PRK06721 592022013473 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 592022013474 homodimer interface [polypeptide binding]; other site 592022013475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592022013476 catalytic residue [active] 592022013477 homoserine dehydrogenase; Provisional; Region: PRK06349 592022013478 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 592022013479 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 592022013480 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 592022013481 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592022013482 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 592022013483 dimerization interface [polypeptide binding]; other site 592022013484 ligand binding site [chemical binding]; other site 592022013485 NADP binding site [chemical binding]; other site 592022013486 catalytic site [active] 592022013487 spore coat protein YutH; Region: spore_yutH; TIGR02905 592022013488 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 592022013489 tetramer interfaces [polypeptide binding]; other site 592022013490 binuclear metal-binding site [ion binding]; other site 592022013491 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 592022013492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022013493 active site 592022013494 motif I; other site 592022013495 motif II; other site 592022013496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022013497 Uncharacterized conserved protein [Function unknown]; Region: COG2445 592022013498 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 592022013499 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 592022013500 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 592022013501 lipoyl synthase; Provisional; Region: PRK05481 592022013502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022013503 FeS/SAM binding site; other site 592022013504 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592022013505 Peptidase family M23; Region: Peptidase_M23; pfam01551 592022013506 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 592022013507 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 592022013508 Uncharacterized conserved protein [Function unknown]; Region: COG1801 592022013509 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 592022013510 FeS assembly protein SufB; Region: sufB; TIGR01980 592022013511 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 592022013512 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 592022013513 trimerization site [polypeptide binding]; other site 592022013514 active site 592022013515 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 592022013516 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 592022013517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592022013518 catalytic residue [active] 592022013519 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 592022013520 FeS assembly protein SufD; Region: sufD; TIGR01981 592022013521 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 592022013522 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 592022013523 Walker A/P-loop; other site 592022013524 ATP binding site [chemical binding]; other site 592022013525 Q-loop/lid; other site 592022013526 ABC transporter signature motif; other site 592022013527 Walker B; other site 592022013528 D-loop; other site 592022013529 H-loop/switch region; other site 592022013530 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592022013531 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592022013532 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592022013533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022013534 dimer interface [polypeptide binding]; other site 592022013535 conserved gate region; other site 592022013536 putative PBP binding loops; other site 592022013537 ABC-ATPase subunit interface; other site 592022013538 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592022013539 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 592022013540 Walker A/P-loop; other site 592022013541 ATP binding site [chemical binding]; other site 592022013542 Q-loop/lid; other site 592022013543 ABC transporter signature motif; other site 592022013544 Walker B; other site 592022013545 D-loop; other site 592022013546 H-loop/switch region; other site 592022013547 NIL domain; Region: NIL; pfam09383 592022013548 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592022013549 catalytic residues [active] 592022013550 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 592022013551 putative active site [active] 592022013552 putative metal binding site [ion binding]; other site 592022013553 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 592022013554 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 592022013555 lipoyl attachment site [posttranslational modification]; other site 592022013556 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 592022013557 ArsC family; Region: ArsC; pfam03960 592022013558 putative ArsC-like catalytic residues; other site 592022013559 putative TRX-like catalytic residues [active] 592022013560 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592022013561 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022013562 active site 592022013563 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 592022013564 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592022013565 dimer interface [polypeptide binding]; other site 592022013566 active site 592022013567 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 592022013568 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592022013569 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592022013570 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592022013571 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 592022013572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592022013573 substrate binding site [chemical binding]; other site 592022013574 oxyanion hole (OAH) forming residues; other site 592022013575 Proline dehydrogenase; Region: Pro_dh; cl03282 592022013576 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 592022013577 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 592022013578 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 592022013579 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 592022013580 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592022013581 Walker A/P-loop; other site 592022013582 ATP binding site [chemical binding]; other site 592022013583 Q-loop/lid; other site 592022013584 ABC transporter signature motif; other site 592022013585 Walker B; other site 592022013586 D-loop; other site 592022013587 H-loop/switch region; other site 592022013588 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 592022013589 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022013590 ABC-ATPase subunit interface; other site 592022013591 dimer interface [polypeptide binding]; other site 592022013592 putative PBP binding regions; other site 592022013593 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592022013594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592022013595 ABC-ATPase subunit interface; other site 592022013596 dimer interface [polypeptide binding]; other site 592022013597 putative PBP binding regions; other site 592022013598 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 592022013599 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 592022013600 siderophore binding site; other site 592022013601 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 592022013602 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592022013603 Protein export membrane protein; Region: SecD_SecF; cl14618 592022013604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022013605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022013606 Protein of unknown function (DUF502); Region: DUF502; cl01107 592022013607 short chain dehydrogenase; Validated; Region: PRK08589 592022013608 classical (c) SDRs; Region: SDR_c; cd05233 592022013609 NAD(P) binding site [chemical binding]; other site 592022013610 active site 592022013611 benzoate transport; Region: 2A0115; TIGR00895 592022013612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022013613 putative substrate translocation pore; other site 592022013614 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592022013615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592022013616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592022013617 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 592022013618 putative dimerization interface [polypeptide binding]; other site 592022013619 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022013620 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592022013621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022013622 dimerization interface [polypeptide binding]; other site 592022013623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022013624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022013625 dimer interface [polypeptide binding]; other site 592022013626 phosphorylation site [posttranslational modification] 592022013627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022013628 ATP binding site [chemical binding]; other site 592022013629 Mg2+ binding site [ion binding]; other site 592022013630 G-X-G motif; other site 592022013631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022013632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022013633 active site 592022013634 phosphorylation site [posttranslational modification] 592022013635 intermolecular recognition site; other site 592022013636 dimerization interface [polypeptide binding]; other site 592022013637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022013638 DNA binding site [nucleotide binding] 592022013639 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 592022013640 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 592022013641 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592022013642 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 592022013643 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592022013644 active site 592022013645 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592022013646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592022013647 putative DNA binding site [nucleotide binding]; other site 592022013648 putative Zn2+ binding site [ion binding]; other site 592022013649 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 592022013650 dimer interface [polypeptide binding]; other site 592022013651 FMN binding site [chemical binding]; other site 592022013652 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 592022013653 MoaE interaction surface [polypeptide binding]; other site 592022013654 MoeB interaction surface [polypeptide binding]; other site 592022013655 thiocarboxylated glycine; other site 592022013656 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 592022013657 MoaE homodimer interface [polypeptide binding]; other site 592022013658 MoaD interaction [polypeptide binding]; other site 592022013659 active site residues [active] 592022013660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592022013661 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 592022013662 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 592022013663 dimer interface [polypeptide binding]; other site 592022013664 putative functional site; other site 592022013665 putative MPT binding site; other site 592022013666 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 592022013667 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 592022013668 ATP binding site [chemical binding]; other site 592022013669 substrate interface [chemical binding]; other site 592022013670 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 592022013671 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 592022013672 GTP binding site; other site 592022013673 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 592022013674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592022013675 FeS/SAM binding site; other site 592022013676 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 592022013677 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 592022013678 Uncharacterized conserved protein [Function unknown]; Region: COG5609 592022013679 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 592022013680 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592022013681 catalytic loop [active] 592022013682 iron binding site [ion binding]; other site 592022013683 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 592022013684 4Fe-4S binding domain; Region: Fer4; pfam00037 592022013685 4Fe-4S binding domain; Region: Fer4; pfam00037 592022013686 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 592022013687 [4Fe-4S] binding site [ion binding]; other site 592022013688 molybdopterin cofactor binding site; other site 592022013689 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 592022013690 molybdopterin cofactor binding site; other site 592022013691 Uncharacterized conserved protein [Function unknown]; Region: COG2427 592022013692 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 592022013693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592022013694 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592022013695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592022013696 dimer interface [polypeptide binding]; other site 592022013697 conserved gate region; other site 592022013698 putative PBP binding loops; other site 592022013699 ABC-ATPase subunit interface; other site 592022013700 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 592022013701 SmpB-tmRNA interface; other site 592022013702 ribonuclease R; Region: RNase_R; TIGR02063 592022013703 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 592022013704 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592022013705 RNB domain; Region: RNB; pfam00773 592022013706 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 592022013707 RNA binding site [nucleotide binding]; other site 592022013708 Esterase/lipase [General function prediction only]; Region: COG1647 592022013709 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 592022013710 enolase; Provisional; Region: eno; PRK00077 592022013711 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 592022013712 dimer interface [polypeptide binding]; other site 592022013713 metal binding site [ion binding]; metal-binding site 592022013714 substrate binding pocket [chemical binding]; other site 592022013715 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 592022013716 phosphoglyceromutase; Provisional; Region: PRK05434 592022013717 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 592022013718 triosephosphate isomerase; Provisional; Region: PRK14565 592022013719 substrate binding site [chemical binding]; other site 592022013720 dimer interface [polypeptide binding]; other site 592022013721 catalytic triad [active] 592022013722 Phosphoglycerate kinase; Region: PGK; pfam00162 592022013723 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 592022013724 substrate binding site [chemical binding]; other site 592022013725 hinge regions; other site 592022013726 ADP binding site [chemical binding]; other site 592022013727 catalytic site [active] 592022013728 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 592022013729 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 592022013730 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592022013731 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 592022013732 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 592022013733 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 592022013734 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 592022013735 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 592022013736 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 592022013737 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 592022013738 Clp protease; Region: CLP_protease; pfam00574 592022013739 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592022013740 oligomer interface [polypeptide binding]; other site 592022013741 active site residues [active] 592022013742 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592022013743 dimerization domain swap beta strand [polypeptide binding]; other site 592022013744 regulatory protein interface [polypeptide binding]; other site 592022013745 active site 592022013746 regulatory phosphorylation site [posttranslational modification]; other site 592022013747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 592022013748 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 592022013749 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 592022013750 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 592022013751 phosphate binding site [ion binding]; other site 592022013752 putative substrate binding pocket [chemical binding]; other site 592022013753 dimer interface [polypeptide binding]; other site 592022013754 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 592022013755 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 592022013756 putative active site [active] 592022013757 nucleotide binding site [chemical binding]; other site 592022013758 nudix motif; other site 592022013759 putative metal binding site [ion binding]; other site 592022013760 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 592022013761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592022013762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592022013763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022013764 binding surface 592022013765 TPR motif; other site 592022013766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592022013767 binding surface 592022013768 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592022013769 TPR motif; other site 592022013770 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 592022013771 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 592022013772 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 592022013773 metal binding site [ion binding]; metal-binding site 592022013774 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 592022013775 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 592022013776 substrate binding site [chemical binding]; other site 592022013777 glutamase interaction surface [polypeptide binding]; other site 592022013778 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 592022013779 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 592022013780 catalytic residues [active] 592022013781 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 592022013782 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 592022013783 putative active site [active] 592022013784 oxyanion strand; other site 592022013785 catalytic triad [active] 592022013786 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 592022013787 putative active site pocket [active] 592022013788 4-fold oligomerization interface [polypeptide binding]; other site 592022013789 metal binding residues [ion binding]; metal-binding site 592022013790 3-fold/trimer interface [polypeptide binding]; other site 592022013791 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 592022013792 histidinol dehydrogenase; Region: hisD; TIGR00069 592022013793 NAD binding site [chemical binding]; other site 592022013794 dimerization interface [polypeptide binding]; other site 592022013795 product binding site; other site 592022013796 substrate binding site [chemical binding]; other site 592022013797 zinc binding site [ion binding]; other site 592022013798 catalytic residues [active] 592022013799 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 592022013800 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 592022013801 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 592022013802 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 592022013803 dimer interface [polypeptide binding]; other site 592022013804 motif 1; other site 592022013805 active site 592022013806 motif 2; other site 592022013807 motif 3; other site 592022013808 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 592022013809 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 592022013810 trimer interface [polypeptide binding]; other site 592022013811 active site 592022013812 substrate binding site [chemical binding]; other site 592022013813 CoA binding site [chemical binding]; other site 592022013814 pyrophosphatase PpaX; Provisional; Region: PRK13288 592022013815 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592022013816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022013817 motif II; other site 592022013818 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 592022013819 HPr kinase/phosphorylase; Provisional; Region: PRK05428 592022013820 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 592022013821 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 592022013822 Hpr binding site; other site 592022013823 active site 592022013824 homohexamer subunit interaction site [polypeptide binding]; other site 592022013825 Predicted membrane protein [Function unknown]; Region: COG1950 592022013826 PspC domain; Region: PspC; pfam04024 592022013827 Uncharacterized conserved protein [Function unknown]; Region: COG3595 592022013828 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 592022013829 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 592022013830 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592022013831 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592022013832 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 592022013833 excinuclease ABC subunit B; Provisional; Region: PRK05298 592022013834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022013835 ATP binding site [chemical binding]; other site 592022013836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022013837 nucleotide binding region [chemical binding]; other site 592022013838 ATP-binding site [chemical binding]; other site 592022013839 Ultra-violet resistance protein B; Region: UvrB; pfam12344 592022013840 PAS domain S-box; Region: sensory_box; TIGR00229 592022013841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022013842 putative active site [active] 592022013843 heme pocket [chemical binding]; other site 592022013844 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592022013845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592022013846 Walker A motif; other site 592022013847 ATP binding site [chemical binding]; other site 592022013848 Walker B motif; other site 592022013849 arginine finger; other site 592022013850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592022013851 Proline dehydrogenase; Region: Pro_dh; cl03282 592022013852 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 592022013853 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592022013854 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592022013855 C-terminal peptidase (prc); Region: prc; TIGR00225 592022013856 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592022013857 protein binding site [polypeptide binding]; other site 592022013858 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 592022013859 Catalytic dyad [active] 592022013860 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592022013861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 592022013862 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592022013863 Peptidase family M23; Region: Peptidase_M23; pfam01551 592022013864 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 592022013865 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 592022013866 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 592022013867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592022013868 Walker A/P-loop; other site 592022013869 ATP binding site [chemical binding]; other site 592022013870 Q-loop/lid; other site 592022013871 ABC transporter signature motif; other site 592022013872 Walker B; other site 592022013873 D-loop; other site 592022013874 H-loop/switch region; other site 592022013875 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 592022013876 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592022013877 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592022013878 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592022013879 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 592022013880 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 592022013881 PhoD-like phosphatase; Region: PhoD; pfam09423 592022013882 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 592022013883 putative active site [active] 592022013884 putative metal binding site [ion binding]; other site 592022013885 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 592022013886 peptide chain release factor 2; Provisional; Region: PRK06746 592022013887 This domain is found in peptide chain release factors; Region: PCRF; smart00937 592022013888 RF-1 domain; Region: RF-1; pfam00472 592022013889 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 592022013890 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 592022013891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022013892 nucleotide binding region [chemical binding]; other site 592022013893 ATP-binding site [chemical binding]; other site 592022013894 SEC-C motif; Region: SEC-C; pfam02810 592022013895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592022013896 Coenzyme A binding pocket [chemical binding]; other site 592022013897 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 592022013898 30S subunit binding site; other site 592022013899 flagellar protein FliS; Validated; Region: fliS; PRK05685 592022013900 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 592022013901 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 592022013902 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 592022013903 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 592022013904 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 592022013905 Na binding site [ion binding]; other site 592022013906 putative glycosylation site [posttranslational modification]; other site 592022013907 putative glycosylation site [posttranslational modification]; other site 592022013908 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 592022013909 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 592022013910 tetramerization interface [polypeptide binding]; other site 592022013911 NAD(P) binding site [chemical binding]; other site 592022013912 catalytic residues [active] 592022013913 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592022013914 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 592022013915 active site 592022013916 NAD binding site [chemical binding]; other site 592022013917 metal binding site [ion binding]; metal-binding site 592022013918 Predicted transcriptional regulators [Transcription]; Region: COG1510 592022013919 carbon storage regulator; Provisional; Region: PRK01712 592022013920 flagellar assembly protein FliW; Provisional; Region: PRK13285 592022013921 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 592022013922 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592022013923 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 592022013924 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 592022013925 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592022013926 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592022013927 FlgN protein; Region: FlgN; pfam05130 592022013928 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 592022013929 flagellar operon protein TIGR03826; Region: YvyF 592022013930 comF family protein; Region: comF; TIGR00201 592022013931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022013932 active site 592022013933 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 592022013934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022013935 ATP binding site [chemical binding]; other site 592022013936 putative Mg++ binding site [ion binding]; other site 592022013937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022013938 nucleotide binding region [chemical binding]; other site 592022013939 ATP-binding site [chemical binding]; other site 592022013940 EDD domain protein, DegV family; Region: DegV; TIGR00762 592022013941 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 592022013942 Protein of unknown function (DUF327); Region: DUF327; pfam03885 592022013943 Flagellar protein FliS; Region: FliS; cl00654 592022013944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592022013945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022013946 active site 592022013947 phosphorylation site [posttranslational modification] 592022013948 intermolecular recognition site; other site 592022013949 dimerization interface [polypeptide binding]; other site 592022013950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592022013951 DNA binding residues [nucleotide binding] 592022013952 dimerization interface [polypeptide binding]; other site 592022013953 Sensor protein DegS; Region: DegS; pfam05384 592022013954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 592022013955 Histidine kinase; Region: HisKA_3; pfam07730 592022013956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022013957 ATP binding site [chemical binding]; other site 592022013958 Mg2+ binding site [ion binding]; other site 592022013959 G-X-G motif; other site 592022013960 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 592022013961 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 592022013962 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 592022013963 Transcriptional regulator [Transcription]; Region: LytR; COG1316 592022013964 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 592022013965 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 592022013966 Mg++ binding site [ion binding]; other site 592022013967 putative catalytic motif [active] 592022013968 substrate binding site [chemical binding]; other site 592022013969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 592022013970 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 592022013971 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 592022013972 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 592022013973 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 592022013974 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592022013975 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592022013976 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 592022013977 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592022013978 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 592022013979 active site 592022013980 tetramer interface; other site 592022013981 Uncharacterized conserved protein [Function unknown]; Region: COG4715 592022013982 SNF2 Helicase protein; Region: DUF3670; pfam12419 592022013983 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 592022013984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592022013985 ATP binding site [chemical binding]; other site 592022013986 putative Mg++ binding site [ion binding]; other site 592022013987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592022013988 nucleotide binding region [chemical binding]; other site 592022013989 ATP-binding site [chemical binding]; other site 592022013990 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022013991 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022013992 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022013993 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592022013994 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592022013995 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592022013996 NlpC/P60 family; Region: NLPC_P60; pfam00877 592022013997 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 592022013998 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592022013999 dimer interface [polypeptide binding]; other site 592022014000 ssDNA binding site [nucleotide binding]; other site 592022014001 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022014002 YwpF-like protein; Region: YwpF; pfam14183 592022014003 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 592022014004 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 592022014005 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592022014006 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 592022014007 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 592022014008 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592022014009 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 592022014010 rod shape-determining protein Mbl; Provisional; Region: PRK13928 592022014011 MreB and similar proteins; Region: MreB_like; cd10225 592022014012 nucleotide binding site [chemical binding]; other site 592022014013 Mg binding site [ion binding]; other site 592022014014 putative protofilament interaction site [polypeptide binding]; other site 592022014015 RodZ interaction site [polypeptide binding]; other site 592022014016 Stage III sporulation protein D; Region: SpoIIID; pfam12116 592022014017 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592022014018 Peptidase family M23; Region: Peptidase_M23; pfam01551 592022014019 Stage II sporulation protein; Region: SpoIID; pfam08486 592022014020 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 592022014021 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 592022014022 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 592022014023 hinge; other site 592022014024 active site 592022014025 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 592022014026 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 592022014027 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 592022014028 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 592022014029 gamma subunit interface [polypeptide binding]; other site 592022014030 epsilon subunit interface [polypeptide binding]; other site 592022014031 LBP interface [polypeptide binding]; other site 592022014032 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 592022014033 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 592022014034 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 592022014035 alpha subunit interaction interface [polypeptide binding]; other site 592022014036 Walker A motif; other site 592022014037 ATP binding site [chemical binding]; other site 592022014038 Walker B motif; other site 592022014039 inhibitor binding site; inhibition site 592022014040 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592022014041 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 592022014042 core domain interface [polypeptide binding]; other site 592022014043 delta subunit interface [polypeptide binding]; other site 592022014044 epsilon subunit interface [polypeptide binding]; other site 592022014045 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 592022014046 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 592022014047 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 592022014048 beta subunit interaction interface [polypeptide binding]; other site 592022014049 Walker A motif; other site 592022014050 ATP binding site [chemical binding]; other site 592022014051 Walker B motif; other site 592022014052 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592022014053 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 592022014054 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 592022014055 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 592022014056 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 592022014057 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 592022014058 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 592022014059 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 592022014060 ATP synthase I chain; Region: ATP_synt_I; pfam03899 592022014061 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 592022014062 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 592022014063 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 592022014064 putative active site [active] 592022014065 catalytic triad [active] 592022014066 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 592022014067 PA/protease or protease-like domain interface [polypeptide binding]; other site 592022014068 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 592022014069 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 592022014070 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 592022014071 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 592022014072 active site 592022014073 homodimer interface [polypeptide binding]; other site 592022014074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592022014075 active site 592022014076 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 592022014077 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 592022014078 dimer interface [polypeptide binding]; other site 592022014079 active site 592022014080 glycine-pyridoxal phosphate binding site [chemical binding]; other site 592022014081 folate binding site [chemical binding]; other site 592022014082 hypothetical protein; Provisional; Region: PRK13690 592022014083 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 592022014084 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 592022014085 Low molecular weight phosphatase family; Region: LMWPc; cd00115 592022014086 active site 592022014087 Predicted membrane protein [Function unknown]; Region: COG1971 592022014088 Domain of unknown function DUF; Region: DUF204; pfam02659 592022014089 Domain of unknown function DUF; Region: DUF204; pfam02659 592022014090 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 592022014091 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 592022014092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592022014093 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 592022014094 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 592022014095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022014096 S-adenosylmethionine binding site [chemical binding]; other site 592022014097 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 592022014098 peptide chain release factor 1; Validated; Region: prfA; PRK00591 592022014099 This domain is found in peptide chain release factors; Region: PCRF; smart00937 592022014100 RF-1 domain; Region: RF-1; pfam00472 592022014101 thymidine kinase; Provisional; Region: PRK04296 592022014102 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 592022014103 transcription termination factor Rho; Provisional; Region: rho; PRK09376 592022014104 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 592022014105 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 592022014106 RNA binding site [nucleotide binding]; other site 592022014107 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 592022014108 multimer interface [polypeptide binding]; other site 592022014109 Walker A motif; other site 592022014110 ATP binding site [chemical binding]; other site 592022014111 Walker B motif; other site 592022014112 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 592022014113 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 592022014114 hinge; other site 592022014115 active site 592022014116 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 592022014117 active site 592022014118 intersubunit interactions; other site 592022014119 catalytic residue [active] 592022014120 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 592022014121 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592022014122 intersubunit interface [polypeptide binding]; other site 592022014123 active site 592022014124 zinc binding site [ion binding]; other site 592022014125 Na+ binding site [ion binding]; other site 592022014126 Response regulator receiver domain; Region: Response_reg; pfam00072 592022014127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022014128 active site 592022014129 phosphorylation site [posttranslational modification] 592022014130 intermolecular recognition site; other site 592022014131 dimerization interface [polypeptide binding]; other site 592022014132 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 592022014133 CTP synthetase; Validated; Region: pyrG; PRK05380 592022014134 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 592022014135 Catalytic site [active] 592022014136 active site 592022014137 UTP binding site [chemical binding]; other site 592022014138 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 592022014139 active site 592022014140 putative oxyanion hole; other site 592022014141 catalytic triad [active] 592022014142 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 592022014143 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 592022014144 B12 binding site [chemical binding]; other site 592022014145 cobalt ligand [ion binding]; other site 592022014146 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592022014147 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 592022014148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592022014149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592022014150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022014151 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 592022014152 FAD binding site [chemical binding]; other site 592022014153 homotetramer interface [polypeptide binding]; other site 592022014154 substrate binding pocket [chemical binding]; other site 592022014155 catalytic base [active] 592022014156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592022014157 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 592022014158 FAD binding site [chemical binding]; other site 592022014159 homotetramer interface [polypeptide binding]; other site 592022014160 substrate binding pocket [chemical binding]; other site 592022014161 catalytic base [active] 592022014162 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 592022014163 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592022014164 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592022014165 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 592022014166 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592022014167 dimer interface [polypeptide binding]; other site 592022014168 active site 592022014169 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 592022014170 4Fe-4S binding domain; Region: Fer4; cl02805 592022014171 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592022014172 Cysteine-rich domain; Region: CCG; pfam02754 592022014173 Cysteine-rich domain; Region: CCG; pfam02754 592022014174 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 592022014175 PLD-like domain; Region: PLDc_2; pfam13091 592022014176 putative active site [active] 592022014177 catalytic site [active] 592022014178 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 592022014179 PLD-like domain; Region: PLDc_2; pfam13091 592022014180 putative active site [active] 592022014181 catalytic site [active] 592022014182 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 592022014183 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 592022014184 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 592022014185 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 592022014186 active site 592022014187 HIGH motif; other site 592022014188 KMSK motif region; other site 592022014189 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 592022014190 tRNA binding surface [nucleotide binding]; other site 592022014191 anticodon binding site; other site 592022014192 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 592022014193 agmatinase; Region: agmatinase; TIGR01230 592022014194 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 592022014195 putative active site [active] 592022014196 Mn binding site [ion binding]; other site 592022014197 spermidine synthase; Provisional; Region: PRK00811 592022014198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022014199 Transglycosylase; Region: Transgly; pfam00912 592022014200 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 592022014201 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 592022014202 YwhD family; Region: YwhD; pfam08741 592022014203 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 592022014204 Peptidase family M50; Region: Peptidase_M50; pfam02163 592022014205 active site 592022014206 putative substrate binding region [chemical binding]; other site 592022014207 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 592022014208 active site 1 [active] 592022014209 dimer interface [polypeptide binding]; other site 592022014210 hexamer interface [polypeptide binding]; other site 592022014211 active site 2 [active] 592022014212 Uncharacterized conserved protein [Function unknown]; Region: COG3465 592022014213 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 592022014214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592022014215 Zn2+ binding site [ion binding]; other site 592022014216 Mg2+ binding site [ion binding]; other site 592022014217 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 592022014218 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 592022014219 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 592022014220 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 592022014221 putative heme peroxidase; Provisional; Region: PRK12276 592022014222 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 592022014223 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 592022014224 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 592022014225 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 592022014226 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 592022014227 ligand binding site [chemical binding]; other site 592022014228 active site 592022014229 UGI interface [polypeptide binding]; other site 592022014230 catalytic site [active] 592022014231 Staygreen protein; Region: Staygreen; pfam12638 592022014232 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 592022014233 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 592022014234 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 592022014235 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592022014236 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 592022014237 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 592022014238 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 592022014239 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592022014240 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 592022014241 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 592022014242 hexamer interface [polypeptide binding]; other site 592022014243 ligand binding site [chemical binding]; other site 592022014244 putative active site [active] 592022014245 NAD(P) binding site [chemical binding]; other site 592022014246 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 592022014247 dimer interface [polypeptide binding]; other site 592022014248 substrate binding site [chemical binding]; other site 592022014249 ATP binding site [chemical binding]; other site 592022014250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022014251 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592022014252 active site 592022014253 motif I; other site 592022014254 motif II; other site 592022014255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022014256 motif II; other site 592022014257 beta-phosphoglucomutase; Region: bPGM; TIGR01990 592022014258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592022014259 motif II; other site 592022014260 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592022014261 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 592022014262 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592022014263 active site turn [active] 592022014264 phosphorylation site [posttranslational modification] 592022014265 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 592022014266 putative catalytic site [active] 592022014267 putative metal binding site [ion binding]; other site 592022014268 putative phosphate binding site [ion binding]; other site 592022014269 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 592022014270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592022014271 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 592022014272 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 592022014273 Ligand binding site; other site 592022014274 Putative Catalytic site; other site 592022014275 DXD motif; other site 592022014276 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 592022014277 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 592022014278 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 592022014279 TrkA-N domain; Region: TrkA_N; pfam02254 592022014280 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 592022014281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022014282 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 592022014283 Walker A/P-loop; other site 592022014284 ATP binding site [chemical binding]; other site 592022014285 Q-loop/lid; other site 592022014286 ABC transporter signature motif; other site 592022014287 Walker B; other site 592022014288 D-loop; other site 592022014289 H-loop/switch region; other site 592022014290 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 592022014291 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592022014292 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 592022014293 Walker A/P-loop; other site 592022014294 ATP binding site [chemical binding]; other site 592022014295 Q-loop/lid; other site 592022014296 ABC transporter signature motif; other site 592022014297 Walker B; other site 592022014298 D-loop; other site 592022014299 H-loop/switch region; other site 592022014300 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 592022014301 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 592022014302 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 592022014303 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 592022014304 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 592022014305 Uncharacterized conserved protein [Function unknown]; Region: COG2966 592022014306 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 592022014307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592022014308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592022014309 DNA binding site [nucleotide binding] 592022014310 domain linker motif; other site 592022014311 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592022014312 dimerization interface [polypeptide binding]; other site 592022014313 ligand binding site [chemical binding]; other site 592022014314 Putative esterase; Region: Esterase; pfam00756 592022014315 S-formylglutathione hydrolase; Region: PLN02442 592022014316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 592022014317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592022014318 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 592022014319 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 592022014320 putative catalytic cysteine [active] 592022014321 gamma-glutamyl kinase; Provisional; Region: PRK05429 592022014322 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 592022014323 nucleotide binding site [chemical binding]; other site 592022014324 homotetrameric interface [polypeptide binding]; other site 592022014325 putative phosphate binding site [ion binding]; other site 592022014326 putative allosteric binding site; other site 592022014327 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 592022014328 Carbon starvation protein CstA; Region: CstA; pfam02554 592022014329 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 592022014330 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 592022014331 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 592022014332 tetramer interface [polypeptide binding]; other site 592022014333 heme binding pocket [chemical binding]; other site 592022014334 NADPH binding site [chemical binding]; other site 592022014335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022014336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022014337 dimer interface [polypeptide binding]; other site 592022014338 phosphorylation site [posttranslational modification] 592022014339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022014340 ATP binding site [chemical binding]; other site 592022014341 Mg2+ binding site [ion binding]; other site 592022014342 G-X-G motif; other site 592022014343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022014344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022014345 active site 592022014346 phosphorylation site [posttranslational modification] 592022014347 intermolecular recognition site; other site 592022014348 dimerization interface [polypeptide binding]; other site 592022014349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022014350 DNA binding site [nucleotide binding] 592022014351 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 592022014352 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 592022014353 active site 592022014354 Na/Ca binding site [ion binding]; other site 592022014355 catalytic site [active] 592022014356 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 592022014357 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 592022014358 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 592022014359 transmembrane helices; other site 592022014360 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 592022014361 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 592022014362 putative RNA binding site [nucleotide binding]; other site 592022014363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022014364 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022014365 Predicted membrane protein [Function unknown]; Region: COG3212 592022014366 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022014367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022014368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022014369 active site 592022014370 phosphorylation site [posttranslational modification] 592022014371 intermolecular recognition site; other site 592022014372 dimerization interface [polypeptide binding]; other site 592022014373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022014374 DNA binding site [nucleotide binding] 592022014375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592022014376 HAMP domain; Region: HAMP; pfam00672 592022014377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022014378 dimer interface [polypeptide binding]; other site 592022014379 phosphorylation site [posttranslational modification] 592022014380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022014381 ATP binding site [chemical binding]; other site 592022014382 Mg2+ binding site [ion binding]; other site 592022014383 G-X-G motif; other site 592022014384 Predicted membrane protein [Function unknown]; Region: COG3212 592022014385 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022014386 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022014387 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022014388 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 592022014389 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 592022014390 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 592022014391 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592022014392 FMN binding site [chemical binding]; other site 592022014393 active site 592022014394 catalytic residues [active] 592022014395 substrate binding site [chemical binding]; other site 592022014396 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 592022014397 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 592022014398 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592022014399 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592022014400 protein binding site [polypeptide binding]; other site 592022014401 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 592022014402 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592022014403 YycH protein; Region: YycI; pfam09648 592022014404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 592022014405 YycH protein; Region: YycH; pfam07435 592022014406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 592022014407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592022014408 dimerization interface [polypeptide binding]; other site 592022014409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592022014410 putative active site [active] 592022014411 heme pocket [chemical binding]; other site 592022014412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592022014413 dimer interface [polypeptide binding]; other site 592022014414 phosphorylation site [posttranslational modification] 592022014415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592022014416 ATP binding site [chemical binding]; other site 592022014417 Mg2+ binding site [ion binding]; other site 592022014418 G-X-G motif; other site 592022014419 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592022014420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592022014421 active site 592022014422 phosphorylation site [posttranslational modification] 592022014423 intermolecular recognition site; other site 592022014424 dimerization interface [polypeptide binding]; other site 592022014425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592022014426 DNA binding site [nucleotide binding] 592022014427 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 592022014428 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 592022014429 GDP-binding site [chemical binding]; other site 592022014430 ACT binding site; other site 592022014431 IMP binding site; other site 592022014432 replicative DNA helicase; Provisional; Region: PRK05748 592022014433 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 592022014434 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 592022014435 Walker A motif; other site 592022014436 ATP binding site [chemical binding]; other site 592022014437 Walker B motif; other site 592022014438 DNA binding loops [nucleotide binding] 592022014439 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 592022014440 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 592022014441 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 592022014442 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 592022014443 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 592022014444 DHH family; Region: DHH; pfam01368 592022014445 DHHA1 domain; Region: DHHA1; pfam02272 592022014446 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 592022014447 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 592022014448 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 592022014449 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592022014450 dimer interface [polypeptide binding]; other site 592022014451 ssDNA binding site [nucleotide binding]; other site 592022014452 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592022014453 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 592022014454 GTP-binding protein YchF; Reviewed; Region: PRK09601 592022014455 YchF GTPase; Region: YchF; cd01900 592022014456 G1 box; other site 592022014457 GTP/Mg2+ binding site [chemical binding]; other site 592022014458 Switch I region; other site 592022014459 G2 box; other site 592022014460 Switch II region; other site 592022014461 G3 box; other site 592022014462 G4 box; other site 592022014463 G5 box; other site 592022014464 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 592022014465 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 592022014466 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592022014467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592022014468 Uncharacterized membrane protein [Function unknown]; Region: COG3949 592022014469 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 592022014470 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 592022014471 ParB-like nuclease domain; Region: ParB; smart00470 592022014472 KorB domain; Region: KorB; pfam08535 592022014473 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 592022014474 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592022014475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592022014476 P-loop; other site 592022014477 Magnesium ion binding site [ion binding]; other site 592022014478 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 592022014479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592022014480 Magnesium ion binding site [ion binding]; other site 592022014481 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 592022014482 ParB-like nuclease domain; Region: ParBc; pfam02195 592022014483 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 592022014484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592022014485 S-adenosylmethionine binding site [chemical binding]; other site 592022014486 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 592022014487 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 592022014488 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 592022014489 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 592022014490 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 592022014491 trmE is a tRNA modification GTPase; Region: trmE; cd04164 592022014492 G1 box; other site 592022014493 GTP/Mg2+ binding site [chemical binding]; other site 592022014494 Switch I region; other site 592022014495 G2 box; other site 592022014496 Switch II region; other site 592022014497 G3 box; other site 592022014498 G4 box; other site 592022014499 G5 box; other site 592022014500 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 592022014501 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 592022014502 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 592022014503 G-X-X-G motif; other site 592022014504 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 592022014505 RxxxH motif; other site 592022014506 OxaA-like protein precursor; Validated; Region: PRK02944 592022014507 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 592022014508 ribonuclease P; Reviewed; Region: rnpA; PRK00499 592022014509 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399