-- dump date 20140618_223110 -- class Genbank::misc_feature -- table misc_feature_note -- id note 545693000001 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 545693000002 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693000003 DNA binding residues [nucleotide binding] 545693000004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693000005 salt bridge; other site 545693000006 non-specific DNA binding site [nucleotide binding]; other site 545693000007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693000008 sequence-specific DNA binding site [nucleotide binding]; other site 545693000009 CopC domain; Region: CopC; pfam04234 545693000010 Copper resistance protein D; Region: CopD; cl00563 545693000011 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 545693000012 Predicted membrane protein [Function unknown]; Region: COG3689 545693000013 Predicted permeases [General function prediction only]; Region: COG0701 545693000014 TIGR03943 family protein; Region: TIGR03943 545693000015 Predicted permeases [General function prediction only]; Region: COG0701 545693000016 Transposase, Mutator family; Region: Transposase_mut; cl19537 545693000017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 545693000018 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693000019 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693000020 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 545693000021 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 545693000022 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693000023 NAD(P) binding site [chemical binding]; other site 545693000024 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 545693000025 L-aspartate oxidase; Provisional; Region: PRK06175 545693000026 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693000027 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693000028 Replication-relaxation; Region: Replic_Relax; pfam13814 545693000029 hypothetical protein; Validated; Region: PRK00124 545693000030 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693000031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 545693000032 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 545693000033 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 545693000034 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 545693000035 putative active site [active] 545693000036 putative NTP binding site [chemical binding]; other site 545693000037 putative nucleic acid binding site [nucleotide binding]; other site 545693000038 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 545693000039 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 545693000040 IDEAL domain; Region: IDEAL; pfam08858 545693000041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693000042 nucleotide binding site [chemical binding]; other site 545693000043 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 545693000044 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 545693000045 active site 545693000046 catalytic residues [active] 545693000047 DNA binding site [nucleotide binding] 545693000048 Int/Topo IB signature motif; other site 545693000049 Helix-turn-helix domain; Region: HTH_17; pfam12728 545693000050 Helix-turn-helix domain; Region: HTH_17; pfam12728 545693000051 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 545693000052 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 545693000053 nucleotide binding site [chemical binding]; other site 545693000054 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 545693000055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693000056 non-specific DNA binding site [nucleotide binding]; other site 545693000057 salt bridge; other site 545693000058 sequence-specific DNA binding site [nucleotide binding]; other site 545693000059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693000060 non-specific DNA binding site [nucleotide binding]; other site 545693000061 salt bridge; other site 545693000062 sequence-specific DNA binding site [nucleotide binding]; other site 545693000063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 545693000064 DNA binding residues [nucleotide binding] 545693000065 dimerization interface [polypeptide binding]; other site 545693000066 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 545693000067 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 545693000068 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693000069 DNA binding residues [nucleotide binding] 545693000070 Telomere length regulation protein; Region: Telomere_reg-2; pfam10193 545693000071 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 545693000072 non-specific DNA interactions [nucleotide binding]; other site 545693000073 DNA binding site [nucleotide binding] 545693000074 sequence specific DNA binding site [nucleotide binding]; other site 545693000075 putative cAMP binding site [chemical binding]; other site 545693000076 Autophagy protein Apg6; Region: APG6; pfam04111 545693000077 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693000078 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 545693000079 methionine aminopeptidase 2; Provisional; Region: PTZ00053 545693000080 YvrJ protein family; Region: YvrJ; pfam12841 545693000081 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 545693000082 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693000083 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 545693000084 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 545693000085 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 545693000086 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 545693000087 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 545693000088 catalytic residues [active] 545693000089 catalytic nucleophile [active] 545693000090 Presynaptic Site I dimer interface [polypeptide binding]; other site 545693000091 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 545693000092 Synaptic Flat tetramer interface [polypeptide binding]; other site 545693000093 Synaptic Site I dimer interface [polypeptide binding]; other site 545693000094 DNA binding site [nucleotide binding] 545693000095 Recombinase; Region: Recombinase; pfam07508 545693000096 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 545693000097 MobA/MobL family; Region: MobA_MobL; pfam03389 545693000098 Protein of unknown function (DUF342); Region: DUF342; cl19219 545693000099 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 545693000100 DnaA N-terminal domain; Region: DnaA_N; pfam11638 545693000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000102 Walker A motif; other site 545693000103 ATP binding site [chemical binding]; other site 545693000104 Walker B motif; other site 545693000105 arginine finger; other site 545693000106 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 545693000107 DnaA box-binding interface [nucleotide binding]; other site 545693000108 DNA polymerase III subunit beta; Validated; Region: PRK05643 545693000109 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 545693000110 putative DNA binding surface [nucleotide binding]; other site 545693000111 dimer interface [polypeptide binding]; other site 545693000112 beta-clamp/clamp loader binding surface; other site 545693000113 beta-clamp/translesion DNA polymerase binding surface; other site 545693000114 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 545693000115 recombination protein F; Reviewed; Region: recF; PRK00064 545693000116 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 545693000117 Walker A/P-loop; other site 545693000118 ATP binding site [chemical binding]; other site 545693000119 Q-loop/lid; other site 545693000120 ABC transporter signature motif; other site 545693000121 Walker B; other site 545693000122 D-loop; other site 545693000123 H-loop/switch region; other site 545693000124 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 545693000125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000126 ATP binding site [chemical binding]; other site 545693000127 Mg2+ binding site [ion binding]; other site 545693000128 G-X-G motif; other site 545693000129 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 545693000130 anchoring element; other site 545693000131 dimer interface [polypeptide binding]; other site 545693000132 ATP binding site [chemical binding]; other site 545693000133 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 545693000134 active site 545693000135 putative metal-binding site [ion binding]; other site 545693000136 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 545693000137 DNA gyrase subunit A; Validated; Region: PRK05560 545693000138 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 545693000139 CAP-like domain; other site 545693000140 active site 545693000141 primary dimer interface [polypeptide binding]; other site 545693000142 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000143 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000144 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000145 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000146 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000147 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000148 YaaC-like Protein; Region: YaaC; pfam14175 545693000149 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 545693000150 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 545693000151 active site 545693000152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 545693000153 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 545693000154 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 545693000155 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 545693000156 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 545693000157 active site 545693000158 multimer interface [polypeptide binding]; other site 545693000159 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 545693000160 predicted active site [active] 545693000161 catalytic triad [active] 545693000162 seryl-tRNA synthetase; Provisional; Region: PRK05431 545693000163 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 545693000164 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 545693000165 dimer interface [polypeptide binding]; other site 545693000166 active site 545693000167 motif 1; other site 545693000168 motif 2; other site 545693000169 motif 3; other site 545693000170 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 545693000171 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 545693000172 Substrate-binding site [chemical binding]; other site 545693000173 Substrate specificity [chemical binding]; other site 545693000174 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 545693000175 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 545693000176 Substrate-binding site [chemical binding]; other site 545693000177 Substrate specificity [chemical binding]; other site 545693000178 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 545693000179 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693000180 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693000181 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 545693000182 active site 545693000183 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 545693000184 catalytic triad [active] 545693000185 conserved cis-peptide bond; other site 545693000186 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 545693000187 nucleoside/Zn binding site; other site 545693000188 dimer interface [polypeptide binding]; other site 545693000189 catalytic motif [active] 545693000190 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 545693000191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000192 Walker A motif; other site 545693000193 ATP binding site [chemical binding]; other site 545693000194 Walker B motif; other site 545693000195 arginine finger; other site 545693000196 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 545693000197 hypothetical protein; Validated; Region: PRK00153 545693000198 recombination protein RecR; Reviewed; Region: recR; PRK00076 545693000199 RecR protein; Region: RecR; pfam02132 545693000200 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 545693000201 putative active site [active] 545693000202 putative metal-binding site [ion binding]; other site 545693000203 tetramer interface [polypeptide binding]; other site 545693000204 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 545693000205 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 545693000206 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 545693000207 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 545693000208 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 545693000209 homodimer interface [polypeptide binding]; other site 545693000210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693000211 catalytic residue [active] 545693000212 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 545693000213 thymidylate kinase; Validated; Region: tmk; PRK00698 545693000214 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 545693000215 TMP-binding site; other site 545693000216 ATP-binding site [chemical binding]; other site 545693000217 Protein of unknown function (DUF970); Region: DUF970; pfam06153 545693000218 DNA polymerase III subunit delta'; Validated; Region: PRK08058 545693000219 DNA polymerase III subunit delta'; Validated; Region: PRK08485 545693000220 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 545693000221 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 545693000222 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 545693000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000224 S-adenosylmethionine binding site [chemical binding]; other site 545693000225 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 545693000226 GIY-YIG motif/motif A; other site 545693000227 putative active site [active] 545693000228 putative metal binding site [ion binding]; other site 545693000229 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 545693000230 putative SAM binding site [chemical binding]; other site 545693000231 putative homodimer interface [polypeptide binding]; other site 545693000232 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693000233 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 545693000234 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 545693000235 active site 545693000236 HIGH motif; other site 545693000237 KMSKS motif; other site 545693000238 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 545693000239 tRNA binding surface [nucleotide binding]; other site 545693000240 anticodon binding site; other site 545693000241 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 545693000242 dimer interface [polypeptide binding]; other site 545693000243 putative tRNA-binding site [nucleotide binding]; other site 545693000244 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 545693000245 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 545693000246 active site 545693000247 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 545693000248 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 545693000249 putative active site [active] 545693000250 putative metal binding site [ion binding]; other site 545693000251 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 545693000252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000253 S-adenosylmethionine binding site [chemical binding]; other site 545693000254 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 545693000255 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 545693000256 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693000257 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 545693000258 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 545693000259 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 545693000260 pur operon repressor; Provisional; Region: PRK09213 545693000261 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 545693000262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000263 active site 545693000264 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 545693000265 homotrimer interaction site [polypeptide binding]; other site 545693000266 putative active site [active] 545693000267 regulatory protein SpoVG; Reviewed; Region: PRK13259 545693000268 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 545693000269 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 545693000270 Substrate binding site; other site 545693000271 Mg++ binding site; other site 545693000272 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 545693000273 active site 545693000274 substrate binding site [chemical binding]; other site 545693000275 CoA binding site [chemical binding]; other site 545693000276 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 545693000277 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 545693000278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000279 active site 545693000280 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 545693000281 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 545693000282 5S rRNA interface [nucleotide binding]; other site 545693000283 CTC domain interface [polypeptide binding]; other site 545693000284 L16 interface [polypeptide binding]; other site 545693000285 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 545693000286 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 545693000287 putative active site [active] 545693000288 catalytic residue [active] 545693000289 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 545693000290 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 545693000291 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 545693000292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693000293 ATP binding site [chemical binding]; other site 545693000294 putative Mg++ binding site [ion binding]; other site 545693000295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693000296 nucleotide binding region [chemical binding]; other site 545693000297 ATP-binding site [chemical binding]; other site 545693000298 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 545693000299 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693000300 stage V sporulation protein T; Region: spore_V_T; TIGR02851 545693000301 GAF domain; Region: GAF_3; pfam13492 545693000302 stage V sporulation protein B; Region: spore_V_B; TIGR02900 545693000303 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 545693000304 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 545693000305 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 545693000306 putative SAM binding site [chemical binding]; other site 545693000307 putative homodimer interface [polypeptide binding]; other site 545693000308 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 545693000309 homodimer interface [polypeptide binding]; other site 545693000310 metal binding site [ion binding]; metal-binding site 545693000311 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 545693000312 homodimer interface [polypeptide binding]; other site 545693000313 active site 545693000314 putative chemical substrate binding site [chemical binding]; other site 545693000315 metal binding site [ion binding]; metal-binding site 545693000316 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693000317 RNA binding surface [nucleotide binding]; other site 545693000318 sporulation protein YabP; Region: spore_yabP; TIGR02892 545693000319 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 545693000320 Septum formation initiator; Region: DivIC; cl17659 545693000321 hypothetical protein; Provisional; Region: PRK08582 545693000322 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 545693000323 RNA binding site [nucleotide binding]; other site 545693000324 stage II sporulation protein E; Region: spore_II_E; TIGR02865 545693000325 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 545693000326 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 545693000327 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 545693000328 metal ion-dependent adhesion site (MIDAS); other site 545693000329 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 545693000330 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693000331 active site 545693000332 ATP binding site [chemical binding]; other site 545693000333 substrate binding site [chemical binding]; other site 545693000334 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 545693000335 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 545693000336 Ligand Binding Site [chemical binding]; other site 545693000337 TilS substrate C-terminal domain; Region: TilS_C; smart00977 545693000338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000339 active site 545693000340 FtsH Extracellular; Region: FtsH_ext; pfam06480 545693000341 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 545693000342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000343 Walker A motif; other site 545693000344 ATP binding site [chemical binding]; other site 545693000345 Walker B motif; other site 545693000346 arginine finger; other site 545693000347 Peptidase family M41; Region: Peptidase_M41; pfam01434 545693000348 pantothenate kinase; Reviewed; Region: PRK13318 545693000349 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 545693000350 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 545693000351 dimerization interface [polypeptide binding]; other site 545693000352 domain crossover interface; other site 545693000353 redox-dependent activation switch; other site 545693000354 cysteine synthase; Region: PLN02565 545693000355 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 545693000356 dimer interface [polypeptide binding]; other site 545693000357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693000358 catalytic residue [active] 545693000359 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 545693000360 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 545693000361 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 545693000362 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 545693000363 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 545693000364 glutamine binding [chemical binding]; other site 545693000365 catalytic triad [active] 545693000366 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 545693000367 homodimer interface [polypeptide binding]; other site 545693000368 substrate-cofactor binding pocket; other site 545693000369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693000370 catalytic residue [active] 545693000371 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 545693000372 homooctamer interface [polypeptide binding]; other site 545693000373 active site 545693000374 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 545693000375 catalytic center binding site [active] 545693000376 ATP binding site [chemical binding]; other site 545693000377 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 545693000378 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 545693000379 dimer interface [polypeptide binding]; other site 545693000380 putative anticodon binding site; other site 545693000381 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 545693000382 motif 1; other site 545693000383 active site 545693000384 motif 2; other site 545693000385 motif 3; other site 545693000386 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 545693000387 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 545693000388 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 545693000389 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 545693000390 ADP binding site [chemical binding]; other site 545693000391 phosphagen binding site; other site 545693000392 substrate specificity loop; other site 545693000393 Clp protease ATP binding subunit; Region: clpC; CHL00095 545693000394 Clp amino terminal domain; Region: Clp_N; pfam02861 545693000395 Clp amino terminal domain; Region: Clp_N; pfam02861 545693000396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000397 Walker A motif; other site 545693000398 ATP binding site [chemical binding]; other site 545693000399 Walker B motif; other site 545693000400 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 545693000401 arginine finger; other site 545693000402 UvrB/uvrC motif; Region: UVR; pfam02151 545693000403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000404 Walker A motif; other site 545693000405 ATP binding site [chemical binding]; other site 545693000406 Walker B motif; other site 545693000407 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 545693000408 DNA repair protein RadA; Provisional; Region: PRK11823 545693000409 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 545693000410 Walker A motif/ATP binding site; other site 545693000411 ATP binding site [chemical binding]; other site 545693000412 Walker B motif; other site 545693000413 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 545693000414 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 545693000415 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 545693000416 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 545693000417 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 545693000418 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 545693000419 Sodium Bile acid symporter family; Region: SBF; cl19217 545693000420 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 545693000421 putative active site [active] 545693000422 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 545693000423 substrate binding site; other site 545693000424 dimer interface; other site 545693000425 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 545693000426 homotrimer interaction site [polypeptide binding]; other site 545693000427 zinc binding site [ion binding]; other site 545693000428 CDP-binding sites; other site 545693000429 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 545693000430 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 545693000431 active site 545693000432 HIGH motif; other site 545693000433 KMSKS motif; other site 545693000434 serine O-acetyltransferase; Region: cysE; TIGR01172 545693000435 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 545693000436 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 545693000437 trimer interface [polypeptide binding]; other site 545693000438 active site 545693000439 substrate binding site [chemical binding]; other site 545693000440 CoA binding site [chemical binding]; other site 545693000441 Mite allergen Blo t 5; Region: Blo-t-5; pfam11642 545693000442 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 545693000443 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 545693000444 active site 545693000445 HIGH motif; other site 545693000446 KMSKS motif; other site 545693000447 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 545693000448 tRNA binding surface [nucleotide binding]; other site 545693000449 anticodon binding site; other site 545693000450 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 545693000451 active site 545693000452 metal binding site [ion binding]; metal-binding site 545693000453 dimerization interface [polypeptide binding]; other site 545693000454 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 545693000455 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 545693000456 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 545693000457 YacP-like NYN domain; Region: NYN_YacP; cl01491 545693000458 RNA polymerase factor sigma-70; Validated; Region: PRK08295 545693000459 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693000460 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693000461 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 545693000462 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 545693000463 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 545693000464 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 545693000465 putative homodimer interface [polypeptide binding]; other site 545693000466 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 545693000467 heterodimer interface [polypeptide binding]; other site 545693000468 homodimer interface [polypeptide binding]; other site 545693000469 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 545693000470 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 545693000471 23S rRNA interface [nucleotide binding]; other site 545693000472 L7/L12 interface [polypeptide binding]; other site 545693000473 putative thiostrepton binding site; other site 545693000474 L25 interface [polypeptide binding]; other site 545693000475 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 545693000476 mRNA/rRNA interface [nucleotide binding]; other site 545693000477 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 545693000478 23S rRNA interface [nucleotide binding]; other site 545693000479 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 545693000480 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 545693000481 peripheral dimer interface [polypeptide binding]; other site 545693000482 core dimer interface [polypeptide binding]; other site 545693000483 L10 interface [polypeptide binding]; other site 545693000484 L11 interface [polypeptide binding]; other site 545693000485 putative EF-Tu interaction site [polypeptide binding]; other site 545693000486 putative EF-G interaction site [polypeptide binding]; other site 545693000487 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 545693000488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000489 S-adenosylmethionine binding site [chemical binding]; other site 545693000490 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 545693000491 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 545693000492 RPB12 interaction site [polypeptide binding]; other site 545693000493 RPB1 interaction site [polypeptide binding]; other site 545693000494 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 545693000495 RPB10 interaction site [polypeptide binding]; other site 545693000496 RPB11 interaction site [polypeptide binding]; other site 545693000497 RPB3 interaction site [polypeptide binding]; other site 545693000498 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 545693000499 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 545693000500 beta and beta' interface [polypeptide binding]; other site 545693000501 beta' and sigma factor interface [polypeptide binding]; other site 545693000502 Zn-binding [ion binding]; other site 545693000503 active site region [active] 545693000504 catalytic site [active] 545693000505 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 545693000506 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 545693000507 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 545693000508 G-loop; other site 545693000509 DNA binding site [nucleotide binding] 545693000510 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 545693000511 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 545693000512 S17 interaction site [polypeptide binding]; other site 545693000513 S8 interaction site; other site 545693000514 16S rRNA interaction site [nucleotide binding]; other site 545693000515 streptomycin interaction site [chemical binding]; other site 545693000516 23S rRNA interaction site [nucleotide binding]; other site 545693000517 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 545693000518 30S ribosomal protein S7; Validated; Region: PRK05302 545693000519 elongation factor G; Reviewed; Region: PRK00007 545693000520 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 545693000521 G1 box; other site 545693000522 putative GEF interaction site [polypeptide binding]; other site 545693000523 GTP/Mg2+ binding site [chemical binding]; other site 545693000524 Switch I region; other site 545693000525 G2 box; other site 545693000526 G3 box; other site 545693000527 Switch II region; other site 545693000528 G4 box; other site 545693000529 G5 box; other site 545693000530 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 545693000531 Elongation Factor G, domain II; Region: EFG_II; pfam14492 545693000532 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 545693000533 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 545693000534 elongation factor Tu; Reviewed; Region: PRK00049 545693000535 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 545693000536 G1 box; other site 545693000537 GEF interaction site [polypeptide binding]; other site 545693000538 GTP/Mg2+ binding site [chemical binding]; other site 545693000539 Switch I region; other site 545693000540 G2 box; other site 545693000541 G3 box; other site 545693000542 Switch II region; other site 545693000543 G4 box; other site 545693000544 G5 box; other site 545693000545 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 545693000546 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 545693000547 Antibiotic Binding Site [chemical binding]; other site 545693000548 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 545693000549 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 545693000550 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 545693000551 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 545693000552 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 545693000553 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 545693000554 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 545693000555 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 545693000556 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 545693000557 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 545693000558 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 545693000559 putative translocon binding site; other site 545693000560 protein-rRNA interface [nucleotide binding]; other site 545693000561 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 545693000562 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 545693000563 G-X-X-G motif; other site 545693000564 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 545693000565 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 545693000566 23S rRNA interface [nucleotide binding]; other site 545693000567 5S rRNA interface [nucleotide binding]; other site 545693000568 putative antibiotic binding site [chemical binding]; other site 545693000569 L25 interface [polypeptide binding]; other site 545693000570 L27 interface [polypeptide binding]; other site 545693000571 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 545693000572 23S rRNA interface [nucleotide binding]; other site 545693000573 putative translocon interaction site; other site 545693000574 signal recognition particle (SRP54) interaction site; other site 545693000575 L23 interface [polypeptide binding]; other site 545693000576 trigger factor interaction site; other site 545693000577 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 545693000578 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 545693000579 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 545693000580 RNA binding site [nucleotide binding]; other site 545693000581 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 545693000582 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 545693000583 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 545693000584 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 545693000585 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 545693000586 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 545693000587 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 545693000588 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 545693000589 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 545693000590 5S rRNA interface [nucleotide binding]; other site 545693000591 L27 interface [polypeptide binding]; other site 545693000592 23S rRNA interface [nucleotide binding]; other site 545693000593 L5 interface [polypeptide binding]; other site 545693000594 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 545693000595 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 545693000596 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 545693000597 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 545693000598 23S rRNA binding site [nucleotide binding]; other site 545693000599 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 545693000600 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 545693000601 SecY translocase; Region: SecY; pfam00344 545693000602 adenylate kinase; Reviewed; Region: adk; PRK00279 545693000603 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 545693000604 AMP-binding site [chemical binding]; other site 545693000605 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 545693000606 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 545693000607 active site 545693000608 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 545693000609 rRNA binding site [nucleotide binding]; other site 545693000610 predicted 30S ribosome binding site; other site 545693000611 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 545693000612 30S ribosomal protein S11; Validated; Region: PRK05309 545693000613 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 545693000614 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 545693000615 alphaNTD homodimer interface [polypeptide binding]; other site 545693000616 alphaNTD - beta interaction site [polypeptide binding]; other site 545693000617 alphaNTD - beta' interaction site [polypeptide binding]; other site 545693000618 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 545693000619 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 545693000620 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 545693000621 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 545693000622 Walker A/P-loop; other site 545693000623 ATP binding site [chemical binding]; other site 545693000624 Q-loop/lid; other site 545693000625 ABC transporter signature motif; other site 545693000626 Walker B; other site 545693000627 D-loop; other site 545693000628 H-loop/switch region; other site 545693000629 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 545693000630 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 545693000631 Walker A/P-loop; other site 545693000632 ATP binding site [chemical binding]; other site 545693000633 Q-loop/lid; other site 545693000634 ABC transporter signature motif; other site 545693000635 Walker B; other site 545693000636 D-loop; other site 545693000637 H-loop/switch region; other site 545693000638 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 545693000639 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 545693000640 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 545693000641 dimerization interface 3.5A [polypeptide binding]; other site 545693000642 active site 545693000643 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 545693000644 23S rRNA interface [nucleotide binding]; other site 545693000645 L3 interface [polypeptide binding]; other site 545693000646 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 545693000647 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 545693000648 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693000649 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693000650 active site 545693000651 metal binding site [ion binding]; metal-binding site 545693000652 Domain of unknown function DUF59; Region: DUF59; cl00941 545693000653 antiporter inner membrane protein; Provisional; Region: PRK11670 545693000654 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 545693000655 Walker A motif; other site 545693000656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693000657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693000658 LysR substrate binding domain; Region: LysR_substrate; pfam03466 545693000659 dimerization interface [polypeptide binding]; other site 545693000660 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 545693000661 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693000662 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 545693000663 Arginase family; Region: Arginase; cd09989 545693000664 active site 545693000665 Mn binding site [ion binding]; other site 545693000666 oligomer interface [polypeptide binding]; other site 545693000667 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693000668 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 545693000669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693000670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693000671 DNA binding residues [nucleotide binding] 545693000672 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 545693000673 Putative zinc-finger; Region: zf-HC2; pfam13490 545693000674 Protein of unknown function (DUF342); Region: DUF342; cl19219 545693000675 Uncharacterized conserved protein [Function unknown]; Region: COG1624 545693000676 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 545693000677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 545693000678 YbbR-like protein; Region: YbbR; pfam07949 545693000679 YbbR-like protein; Region: YbbR; pfam07949 545693000680 NOA36 protein; Region: NOA36; pfam06524 545693000681 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 545693000682 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 545693000683 active site 545693000684 substrate binding site [chemical binding]; other site 545693000685 metal binding site [ion binding]; metal-binding site 545693000686 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 545693000687 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 545693000688 glutaminase active site [active] 545693000689 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 545693000690 dimer interface [polypeptide binding]; other site 545693000691 active site 545693000692 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 545693000693 dimer interface [polypeptide binding]; other site 545693000694 active site 545693000695 hypothetical protein; Provisional; Region: PRK12378 545693000696 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 545693000697 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693000698 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693000699 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693000700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 545693000701 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 545693000702 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 545693000703 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 545693000704 active site 545693000705 P-loop; other site 545693000706 phosphorylation site [posttranslational modification] 545693000707 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693000708 active site 545693000709 phosphorylation site [posttranslational modification] 545693000710 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693000711 HTH domain; Region: HTH_11; pfam08279 545693000712 PRD domain; Region: PRD; pfam00874 545693000713 PRD domain; Region: PRD; pfam00874 545693000714 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693000715 active site 545693000716 P-loop; other site 545693000717 phosphorylation site [posttranslational modification] 545693000718 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 545693000719 active site 545693000720 phosphorylation site [posttranslational modification] 545693000721 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 545693000722 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 545693000723 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 545693000724 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693000725 active site 545693000726 metal binding site [ion binding]; metal-binding site 545693000727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693000728 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693000729 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 545693000730 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693000731 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 545693000732 Sulfatase; Region: Sulfatase; pfam00884 545693000733 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 545693000734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693000735 non-specific DNA binding site [nucleotide binding]; other site 545693000736 salt bridge; other site 545693000737 sequence-specific DNA binding site [nucleotide binding]; other site 545693000738 Cupin domain; Region: Cupin_2; cl17218 545693000739 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 545693000740 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 545693000741 Walker A/P-loop; other site 545693000742 ATP binding site [chemical binding]; other site 545693000743 Q-loop/lid; other site 545693000744 ABC transporter signature motif; other site 545693000745 Walker B; other site 545693000746 D-loop; other site 545693000747 H-loop/switch region; other site 545693000748 TOBE domain; Region: TOBE_2; pfam08402 545693000749 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693000750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693000751 dimer interface [polypeptide binding]; other site 545693000752 conserved gate region; other site 545693000753 putative PBP binding loops; other site 545693000754 ABC-ATPase subunit interface; other site 545693000755 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693000756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693000757 dimer interface [polypeptide binding]; other site 545693000758 conserved gate region; other site 545693000759 putative PBP binding loops; other site 545693000760 ABC-ATPase subunit interface; other site 545693000761 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 545693000762 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693000763 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693000764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693000765 active site 545693000766 phosphorylation site [posttranslational modification] 545693000767 intermolecular recognition site; other site 545693000768 dimerization interface [polypeptide binding]; other site 545693000769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693000770 DNA binding site [nucleotide binding] 545693000771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693000772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693000773 dimer interface [polypeptide binding]; other site 545693000774 phosphorylation site [posttranslational modification] 545693000775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000776 ATP binding site [chemical binding]; other site 545693000777 Mg2+ binding site [ion binding]; other site 545693000778 G-X-G motif; other site 545693000779 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 545693000780 ApbE family; Region: ApbE; pfam02424 545693000781 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 545693000782 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 545693000783 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 545693000784 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 545693000785 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693000786 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693000787 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693000788 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 545693000789 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693000790 ATP binding site [chemical binding]; other site 545693000791 Mg++ binding site [ion binding]; other site 545693000792 motif III; other site 545693000793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693000794 nucleotide binding region [chemical binding]; other site 545693000795 ATP-binding site [chemical binding]; other site 545693000796 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 545693000797 Rhomboid family; Region: Rhomboid; pfam01694 545693000798 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 545693000799 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 545693000800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 545693000801 alanine racemase; Reviewed; Region: alr; PRK00053 545693000802 active site 545693000803 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693000804 dimer interface [polypeptide binding]; other site 545693000805 substrate binding site [chemical binding]; other site 545693000806 catalytic residues [active] 545693000807 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 545693000808 PemK-like protein; Region: PemK; pfam02452 545693000809 Rsbr N terminal; Region: Rsbr_N; pfam08678 545693000810 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693000811 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693000812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693000813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000814 ATP binding site [chemical binding]; other site 545693000815 Mg2+ binding site [ion binding]; other site 545693000816 G-X-G motif; other site 545693000817 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 545693000818 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 545693000819 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 545693000820 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 545693000821 anti sigma factor interaction site; other site 545693000822 regulatory phosphorylation site [posttranslational modification]; other site 545693000823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000824 ATP binding site [chemical binding]; other site 545693000825 Mg2+ binding site [ion binding]; other site 545693000826 G-X-G motif; other site 545693000827 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 545693000828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693000829 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693000830 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693000831 DNA binding residues [nucleotide binding] 545693000832 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 545693000833 active site 545693000834 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 545693000835 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 545693000836 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 545693000837 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 545693000838 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 545693000839 RNA binding site [nucleotide binding]; other site 545693000840 hypothetical protein; Provisional; Region: PRK04351 545693000841 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 545693000842 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 545693000843 Glycoprotease family; Region: Peptidase_M22; pfam00814 545693000844 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 545693000845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693000846 Coenzyme A binding pocket [chemical binding]; other site 545693000847 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 545693000848 UGMP family protein; Validated; Region: PRK09604 545693000849 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 545693000850 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693000851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693000852 ABC transporter; Region: ABC_tran_2; pfam12848 545693000853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693000854 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 545693000855 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 545693000856 CoA binding domain; Region: CoA_binding; pfam02629 545693000857 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 545693000858 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 545693000859 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 545693000860 CAAX protease self-immunity; Region: Abi; pfam02517 545693000861 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 545693000862 oligomerisation interface [polypeptide binding]; other site 545693000863 mobile loop; other site 545693000864 roof hairpin; other site 545693000865 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 545693000866 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 545693000867 ring oligomerisation interface [polypeptide binding]; other site 545693000868 ATP/Mg binding site [chemical binding]; other site 545693000869 stacking interactions; other site 545693000870 hinge regions; other site 545693000871 MoxR-like ATPases [General function prediction only]; Region: COG0714 545693000872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000873 Walker A motif; other site 545693000874 ATP binding site [chemical binding]; other site 545693000875 Walker B motif; other site 545693000876 arginine finger; other site 545693000877 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 545693000878 Protein of unknown function DUF58; Region: DUF58; pfam01882 545693000879 BOP1NT (NUC169) domain; Region: BOP1NT; cl19763 545693000880 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 545693000881 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 545693000882 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 545693000883 GMP synthase; Reviewed; Region: guaA; PRK00074 545693000884 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 545693000885 AMP/PPi binding site [chemical binding]; other site 545693000886 candidate oxyanion hole; other site 545693000887 catalytic triad [active] 545693000888 potential glutamine specificity residues [chemical binding]; other site 545693000889 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 545693000890 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 545693000891 ATP Binding subdomain [chemical binding]; other site 545693000892 Ligand Binding sites [chemical binding]; other site 545693000893 Dimerization subdomain; other site 545693000894 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693000895 NETI protein; Region: NETI; pfam14044 545693000896 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 545693000897 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 545693000898 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 545693000899 NAD binding site [chemical binding]; other site 545693000900 ATP-grasp domain; Region: ATP-grasp; pfam02222 545693000901 adenylosuccinate lyase; Provisional; Region: PRK07492 545693000902 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 545693000903 tetramer interface [polypeptide binding]; other site 545693000904 active site 545693000905 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 545693000906 ATP binding site [chemical binding]; other site 545693000907 active site 545693000908 substrate binding site [chemical binding]; other site 545693000909 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 545693000910 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 545693000911 putative active site [active] 545693000912 catalytic triad [active] 545693000913 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 545693000914 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 545693000915 dimerization interface [polypeptide binding]; other site 545693000916 ATP binding site [chemical binding]; other site 545693000917 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 545693000918 dimerization interface [polypeptide binding]; other site 545693000919 ATP binding site [chemical binding]; other site 545693000920 amidophosphoribosyltransferase; Provisional; Region: PRK07631 545693000921 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 545693000922 active site 545693000923 tetramer interface [polypeptide binding]; other site 545693000924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000925 active site 545693000926 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 545693000927 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 545693000928 dimerization interface [polypeptide binding]; other site 545693000929 putative ATP binding site [chemical binding]; other site 545693000930 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 545693000931 active site 545693000932 substrate binding site [chemical binding]; other site 545693000933 cosubstrate binding site; other site 545693000934 catalytic site [active] 545693000935 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 545693000936 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 545693000937 purine monophosphate binding site [chemical binding]; other site 545693000938 dimer interface [polypeptide binding]; other site 545693000939 putative catalytic residues [active] 545693000940 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 545693000941 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 545693000942 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 545693000943 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 545693000944 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 545693000945 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 545693000946 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 545693000947 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693000948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693000949 active site 545693000950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 545693000951 glycyl-tRNA synthetase; Provisional; Region: PRK04173 545693000952 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 545693000953 dimer interface [polypeptide binding]; other site 545693000954 motif 1; other site 545693000955 active site 545693000956 motif 2; other site 545693000957 motif 3; other site 545693000958 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 545693000959 anticodon binding site; other site 545693000960 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 545693000961 substrate binding site [chemical binding]; other site 545693000962 putative active site [active] 545693000963 dimer interface [polypeptide binding]; other site 545693000964 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 545693000965 Part of AAA domain; Region: AAA_19; pfam13245 545693000966 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 545693000967 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 545693000968 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 545693000969 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 545693000970 nucleotide binding pocket [chemical binding]; other site 545693000971 K-X-D-G motif; other site 545693000972 catalytic site [active] 545693000973 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 545693000974 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 545693000975 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 545693000976 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 545693000977 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 545693000978 Dimer interface [polypeptide binding]; other site 545693000979 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 545693000980 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 545693000981 putative dimer interface [polypeptide binding]; other site 545693000982 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 545693000983 putative dimer interface [polypeptide binding]; other site 545693000984 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 545693000985 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 545693000986 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 545693000987 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 545693000988 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 545693000989 GatB domain; Region: GatB_Yqey; pfam02637 545693000990 putative lipid kinase; Reviewed; Region: PRK13337 545693000991 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 545693000992 TRAM domain; Region: TRAM; cl01282 545693000993 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 545693000994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000995 S-adenosylmethionine binding site [chemical binding]; other site 545693000996 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693000997 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693000998 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693000999 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693001000 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 545693001001 G3 box; other site 545693001002 Switch II region; other site 545693001003 GTP/Mg2+ binding site [chemical binding]; other site 545693001004 G4 box; other site 545693001005 G5 box; other site 545693001006 DNA binding domain, excisionase family; Region: excise; TIGR01764 545693001007 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 545693001008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 545693001009 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 545693001010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001011 dimerization interface [polypeptide binding]; other site 545693001012 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693001013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001014 dimer interface [polypeptide binding]; other site 545693001015 phosphorylation site [posttranslational modification] 545693001016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001017 ATP binding site [chemical binding]; other site 545693001018 Mg2+ binding site [ion binding]; other site 545693001019 G-X-G motif; other site 545693001020 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 545693001021 active site 545693001022 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 545693001023 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 545693001024 Nitronate monooxygenase; Region: NMO; pfam03060 545693001025 FMN binding site [chemical binding]; other site 545693001026 substrate binding site [chemical binding]; other site 545693001027 putative catalytic residue [active] 545693001028 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693001029 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 545693001030 DNA binding residues [nucleotide binding] 545693001031 drug binding residues [chemical binding]; other site 545693001032 dimer interface [polypeptide binding]; other site 545693001033 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693001034 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 545693001035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001036 putative substrate translocation pore; other site 545693001037 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 545693001038 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693001039 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 545693001040 Walker A/P-loop; other site 545693001041 ATP binding site [chemical binding]; other site 545693001042 Q-loop/lid; other site 545693001043 ABC transporter signature motif; other site 545693001044 Walker B; other site 545693001045 D-loop; other site 545693001046 H-loop/switch region; other site 545693001047 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693001048 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693001049 substrate binding pocket [chemical binding]; other site 545693001050 membrane-bound complex binding site; other site 545693001051 hinge residues; other site 545693001052 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693001053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001054 dimer interface [polypeptide binding]; other site 545693001055 conserved gate region; other site 545693001056 putative PBP binding loops; other site 545693001057 ABC-ATPase subunit interface; other site 545693001058 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693001059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001060 dimer interface [polypeptide binding]; other site 545693001061 conserved gate region; other site 545693001062 putative PBP binding loops; other site 545693001063 ABC-ATPase subunit interface; other site 545693001064 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693001065 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693001066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 545693001067 Protein of unknown function (DUF445); Region: DUF445; pfam04286 545693001068 Predicted membrane protein [Function unknown]; Region: COG3212 545693001069 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693001070 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693001071 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693001072 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693001073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693001074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001075 dimerization interface [polypeptide binding]; other site 545693001076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001077 dimer interface [polypeptide binding]; other site 545693001078 phosphorylation site [posttranslational modification] 545693001079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001080 ATP binding site [chemical binding]; other site 545693001081 Mg2+ binding site [ion binding]; other site 545693001082 G-X-G motif; other site 545693001083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693001084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693001085 active site 545693001086 phosphorylation site [posttranslational modification] 545693001087 intermolecular recognition site; other site 545693001088 dimerization interface [polypeptide binding]; other site 545693001089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693001090 DNA binding site [nucleotide binding] 545693001091 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693001092 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693001093 active site 545693001094 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 545693001095 High-affinity nickel-transport protein; Region: NicO; cl00964 545693001096 glutamate carboxypeptidase; Reviewed; Region: PRK06133 545693001097 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 545693001098 metal binding site [ion binding]; metal-binding site 545693001099 dimer interface [polypeptide binding]; other site 545693001100 Predicted membrane protein [Function unknown]; Region: COG2259 545693001101 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 545693001102 intracellular protease, PfpI family; Region: PfpI; TIGR01382 545693001103 proposed catalytic triad [active] 545693001104 conserved cys residue [active] 545693001105 DinB superfamily; Region: DinB_2; pfam12867 545693001106 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 545693001107 active site flap/lid [active] 545693001108 nucleophilic elbow; other site 545693001109 catalytic triad [active] 545693001110 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 545693001111 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 545693001112 Predicted membrane protein [Function unknown]; Region: COG4129 545693001113 Occludin homology domain; Region: Occludin_ELL; pfam07303 545693001114 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 545693001115 amidohydrolase; Region: amidohydrolases; TIGR01891 545693001116 metal binding site [ion binding]; metal-binding site 545693001117 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 545693001118 dinuclear metal binding motif [ion binding]; other site 545693001119 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693001120 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 545693001121 oligomer interface [polypeptide binding]; other site 545693001122 metal binding site [ion binding]; metal-binding site 545693001123 metal binding site [ion binding]; metal-binding site 545693001124 putative Cl binding site [ion binding]; other site 545693001125 aspartate ring; other site 545693001126 basic sphincter; other site 545693001127 hydrophobic gate; other site 545693001128 periplasmic entrance; other site 545693001129 sensory histidine kinase DcuS; Provisional; Region: PRK11086 545693001130 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 545693001131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693001132 putative active site [active] 545693001133 heme pocket [chemical binding]; other site 545693001134 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 545693001135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001136 ATP binding site [chemical binding]; other site 545693001137 Mg2+ binding site [ion binding]; other site 545693001138 G-X-G motif; other site 545693001139 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 545693001140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693001141 active site 545693001142 phosphorylation site [posttranslational modification] 545693001143 intermolecular recognition site; other site 545693001144 dimerization interface [polypeptide binding]; other site 545693001145 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 545693001146 DNA-binding site [nucleotide binding]; DNA binding site 545693001147 B12 binding domain; Region: B12-binding_2; pfam02607 545693001148 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 545693001149 B12 binding site [chemical binding]; other site 545693001150 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693001151 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693001152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693001153 putative active site [active] 545693001154 heme pocket [chemical binding]; other site 545693001155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001156 dimer interface [polypeptide binding]; other site 545693001157 phosphorylation site [posttranslational modification] 545693001158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001159 ATP binding site [chemical binding]; other site 545693001160 Mg2+ binding site [ion binding]; other site 545693001161 G-X-G motif; other site 545693001162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 545693001163 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693001164 ATP binding site [chemical binding]; other site 545693001165 putative Mg++ binding site [ion binding]; other site 545693001166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693001167 nucleotide binding region [chemical binding]; other site 545693001168 ATP-binding site [chemical binding]; other site 545693001169 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 545693001170 SseB protein N-terminal domain; Region: SseB; pfam07179 545693001171 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 545693001172 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 545693001173 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 545693001174 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 545693001175 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 545693001176 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693001177 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693001178 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 545693001179 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 545693001180 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 545693001181 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 545693001182 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 545693001183 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 545693001184 Endonuclease I; Region: Endonuclease_1; pfam04231 545693001185 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 545693001186 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 545693001187 starch-binding site 2 [chemical binding]; other site 545693001188 starch-binding site 1 [chemical binding]; other site 545693001189 methionine sulfoxide reductase A; Provisional; Region: PRK14054 545693001190 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 545693001191 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693001192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693001193 ABC transporter; Region: ABC_tran_2; pfam12848 545693001194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693001195 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 545693001196 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 545693001197 NAD binding site [chemical binding]; other site 545693001198 ligand binding site [chemical binding]; other site 545693001199 catalytic site [active] 545693001200 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 545693001201 active site 545693001202 dimer interface [polypeptide binding]; other site 545693001203 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 545693001204 Transcriptional regulator; Region: Rrf2; cl17282 545693001205 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693001206 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 545693001207 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 545693001208 heme-binding site [chemical binding]; other site 545693001209 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 545693001210 FAD binding pocket [chemical binding]; other site 545693001211 FAD binding motif [chemical binding]; other site 545693001212 phosphate binding motif [ion binding]; other site 545693001213 beta-alpha-beta structure motif; other site 545693001214 NAD binding pocket [chemical binding]; other site 545693001215 Heme binding pocket [chemical binding]; other site 545693001216 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 545693001217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693001218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693001219 intracellular protease, PfpI family; Region: PfpI; TIGR01382 545693001220 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 545693001221 proposed catalytic triad [active] 545693001222 conserved cys residue [active] 545693001223 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 545693001224 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 545693001225 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 545693001226 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693001227 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 545693001228 active site 545693001229 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 545693001230 Low molecular weight phosphatase family; Region: LMWPc; cd00115 545693001231 active site 545693001232 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 545693001233 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 545693001234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693001235 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 545693001236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001237 motif II; other site 545693001238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693001239 dimerization interface [polypeptide binding]; other site 545693001240 putative DNA binding site [nucleotide binding]; other site 545693001241 putative Zn2+ binding site [ion binding]; other site 545693001242 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 545693001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693001245 putative substrate translocation pore; other site 545693001246 Phenolic Acid Decarboxylase; Region: PAD; cd14241 545693001247 active site 545693001248 dimer interface [polypeptide binding]; other site 545693001249 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 545693001250 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 545693001251 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 545693001252 calcium/proton exchanger (cax); Region: cax; TIGR00378 545693001253 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693001254 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693001255 YfkD-like protein; Region: YfkD; pfam14167 545693001256 Radical SAM superfamily; Region: Radical_SAM; pfam04055 545693001257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693001258 FeS/SAM binding site; other site 545693001259 YfkB-like domain; Region: YfkB; pfam08756 545693001260 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 545693001261 Fumarase C-terminus; Region: Fumerase_C; pfam05683 545693001262 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 545693001263 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 545693001264 NodB motif; other site 545693001265 active site 545693001266 catalytic site [active] 545693001267 Cd binding site [ion binding]; other site 545693001268 TRAM domain; Region: TRAM; pfam01938 545693001269 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 545693001270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693001271 S-adenosylmethionine binding site [chemical binding]; other site 545693001272 putative FAD-dependent oxidoreductase, frameshift 545693001273 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693001274 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693001275 Cache domain; Region: Cache_1; pfam02743 545693001276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 545693001277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001278 dimerization interface [polypeptide binding]; other site 545693001279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693001280 putative active site [active] 545693001281 heme pocket [chemical binding]; other site 545693001282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001283 dimer interface [polypeptide binding]; other site 545693001284 phosphorylation site [posttranslational modification] 545693001285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001286 ATP binding site [chemical binding]; other site 545693001287 Mg2+ binding site [ion binding]; other site 545693001288 G-X-G motif; other site 545693001289 YfhE-like protein; Region: YfhE; pfam14152 545693001290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693001291 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 545693001292 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 545693001293 active site 545693001294 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 545693001295 TIGR01777 family protein; Region: yfcH 545693001296 putative NAD(P) binding site [chemical binding]; other site 545693001297 putative active site [active] 545693001298 recombination regulator RecX; Provisional; Region: recX; PRK14135 545693001299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001300 short chain dehydrogenase; Region: adh_short; pfam00106 545693001301 NAD(P) binding site [chemical binding]; other site 545693001302 active site 545693001303 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 545693001304 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 545693001305 WVELL protein; Region: WVELL; pfam14043 545693001306 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 545693001307 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 545693001308 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 545693001309 minor groove reading motif; other site 545693001310 helix-hairpin-helix signature motif; other site 545693001311 substrate binding pocket [chemical binding]; other site 545693001312 active site 545693001313 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 545693001314 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 545693001315 DNA binding and oxoG recognition site [nucleotide binding] 545693001316 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 545693001317 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 545693001318 putative NAD(P) binding site [chemical binding]; other site 545693001319 active site 545693001320 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 545693001321 YgaB-like protein; Region: YgaB; pfam14182 545693001322 hypothetical protein; Provisional; Region: PRK13662 545693001323 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693001324 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693001325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693001326 Walker A/P-loop; other site 545693001327 ATP binding site [chemical binding]; other site 545693001328 Q-loop/lid; other site 545693001329 ABC transporter signature motif; other site 545693001330 Walker B; other site 545693001331 D-loop; other site 545693001332 H-loop/switch region; other site 545693001333 Predicted membrane protein [Function unknown]; Region: COG4129 545693001334 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 545693001335 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 545693001336 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693001337 inhibitor-cofactor binding pocket; inhibition site 545693001338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001339 catalytic residue [active] 545693001340 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 545693001341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693001342 Walker A/P-loop; other site 545693001343 ATP binding site [chemical binding]; other site 545693001344 Q-loop/lid; other site 545693001345 ABC transporter signature motif; other site 545693001346 Walker B; other site 545693001347 D-loop; other site 545693001348 H-loop/switch region; other site 545693001349 ABC-2 type transporter; Region: ABC2_membrane; cl17235 545693001350 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 545693001351 Ion channel; Region: Ion_trans_2; pfam07885 545693001352 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 545693001353 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 545693001354 catalytic triad [active] 545693001355 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 545693001356 metal binding site 2 [ion binding]; metal-binding site 545693001357 putative DNA binding helix; other site 545693001358 metal binding site 1 [ion binding]; metal-binding site 545693001359 dimer interface [polypeptide binding]; other site 545693001360 structural Zn2+ binding site [ion binding]; other site 545693001361 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 545693001362 Nucleotidyltransferase-like; Region: NTF-like; pfam14540 545693001363 B3/4 domain; Region: B3_4; cl19243 545693001364 epoxyqueuosine reductase; Region: TIGR00276 545693001365 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 545693001366 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 545693001367 HEAT-like repeat; Region: HEAT_EZ; pfam13513 545693001368 Putative amidase domain; Region: Amidase_6; pfam12671 545693001369 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 545693001370 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 545693001371 PrkA AAA domain; Region: AAA_PrkA; smart00763 545693001372 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 545693001373 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 545693001374 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693001375 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693001376 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 545693001377 VanZ like family; Region: VanZ; pfam04892 545693001378 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 545693001379 ThiC-associated domain; Region: ThiC-associated; pfam13667 545693001380 ThiC family; Region: ThiC; pfam01964 545693001381 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 545693001382 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693001383 Domain of unknown function DUF20; Region: UPF0118; cl00465 545693001384 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 545693001385 EcsC protein family; Region: EcsC; pfam12787 545693001386 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693001387 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693001388 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 545693001389 Melibiase; Region: Melibiase; pfam02065 545693001390 biotin synthase; Validated; Region: PRK06256 545693001391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693001392 FeS/SAM binding site; other site 545693001393 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 545693001394 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 545693001395 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 545693001396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693001397 Walker A/P-loop; other site 545693001398 ATP binding site [chemical binding]; other site 545693001399 Q-loop/lid; other site 545693001400 ABC transporter signature motif; other site 545693001401 Walker B; other site 545693001402 D-loop; other site 545693001403 H-loop/switch region; other site 545693001404 TOBE domain; Region: TOBE_2; pfam08402 545693001405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001406 dimer interface [polypeptide binding]; other site 545693001407 conserved gate region; other site 545693001408 putative PBP binding loops; other site 545693001409 ABC-ATPase subunit interface; other site 545693001410 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693001411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001412 dimer interface [polypeptide binding]; other site 545693001413 conserved gate region; other site 545693001414 putative PBP binding loops; other site 545693001415 ABC-ATPase subunit interface; other site 545693001416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693001417 hypothetical protein; Provisional; Region: PRK11622 545693001418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 545693001419 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693001420 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 545693001421 active site 545693001422 catalytic site [active] 545693001423 metal binding site [ion binding]; metal-binding site 545693001424 dimer interface [polypeptide binding]; other site 545693001425 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 545693001426 Predicted integral membrane protein [Function unknown]; Region: COG5505 545693001427 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 545693001428 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 545693001429 active site 545693001430 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693001431 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693001432 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693001433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001434 Coenzyme A binding pocket [chemical binding]; other site 545693001435 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693001436 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 545693001437 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693001438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693001439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 545693001440 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 545693001441 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 545693001442 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693001443 Bacterial SH3 domain homologues; Region: SH3b; smart00287 545693001444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001445 Coenzyme A binding pocket [chemical binding]; other site 545693001446 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 545693001447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001448 Coenzyme A binding pocket [chemical binding]; other site 545693001449 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 545693001450 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693001451 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693001452 putative active site [active] 545693001453 catalytic site [active] 545693001454 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693001455 putative active site [active] 545693001456 catalytic site [active] 545693001457 Heat induced stress protein YflT; Region: YflT; pfam11181 545693001458 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693001459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693001460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693001461 DNA binding site [nucleotide binding] 545693001462 domain linker motif; other site 545693001463 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693001464 dimerization interface [polypeptide binding]; other site 545693001465 ligand binding site [chemical binding]; other site 545693001466 polyol permease family; Region: 2A0118; TIGR00897 545693001467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001468 putative substrate translocation pore; other site 545693001469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693001470 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693001471 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693001472 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693001473 substrate binding site [chemical binding]; other site 545693001474 ATP binding site [chemical binding]; other site 545693001475 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 545693001476 tetrameric interface [polypeptide binding]; other site 545693001477 NAD binding site [chemical binding]; other site 545693001478 catalytic residues [active] 545693001479 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 545693001480 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693001481 PYR/PP interface [polypeptide binding]; other site 545693001482 dimer interface [polypeptide binding]; other site 545693001483 TPP binding site [chemical binding]; other site 545693001484 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693001485 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 545693001486 TPP-binding site; other site 545693001487 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693001488 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693001489 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693001490 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693001491 DNA binding site [nucleotide binding] 545693001492 domain linker motif; other site 545693001493 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693001494 dimerization interface [polypeptide binding]; other site 545693001495 ligand binding site [chemical binding]; other site 545693001496 KduI/IolB family; Region: KduI; pfam04962 545693001497 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693001498 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693001499 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693001500 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693001501 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693001502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693001503 putative DNA binding site [nucleotide binding]; other site 545693001504 putative Zn2+ binding site [ion binding]; other site 545693001505 QueT transporter; Region: QueT; pfam06177 545693001506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693001508 putative substrate translocation pore; other site 545693001509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693001510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693001511 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 545693001512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693001513 RNA binding surface [nucleotide binding]; other site 545693001514 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 545693001515 probable active site [active] 545693001516 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 545693001517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693001518 S-adenosylmethionine binding site [chemical binding]; other site 545693001519 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 545693001520 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 545693001521 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 545693001522 cell division protein FtsZ; Validated; Region: PRK09330 545693001523 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 545693001524 nucleotide binding site [chemical binding]; other site 545693001525 SulA interaction site; other site 545693001526 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693001527 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 545693001528 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693001529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001530 Coenzyme A binding pocket [chemical binding]; other site 545693001531 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 545693001532 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 545693001533 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 545693001534 active site 545693001535 EamA-like transporter family; Region: EamA; pfam00892 545693001536 SET domain; Region: SET; pfam00856 545693001537 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 545693001538 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 545693001539 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693001540 NAD(P) binding site [chemical binding]; other site 545693001541 L-lactate permease; Region: Lactate_perm; cl00701 545693001542 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 545693001543 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 545693001544 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693001545 NAD binding site [chemical binding]; other site 545693001546 dimer interface [polypeptide binding]; other site 545693001547 substrate binding site [chemical binding]; other site 545693001548 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 545693001549 Cache domain; Region: Cache_1; pfam02743 545693001550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001551 dimerization interface [polypeptide binding]; other site 545693001552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 545693001553 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 545693001554 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 545693001555 dimer interface [polypeptide binding]; other site 545693001556 putative CheW interface [polypeptide binding]; other site 545693001557 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 545693001558 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 545693001559 active site 545693001560 SurA N-terminal domain; Region: SurA_N_3; cl07813 545693001561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693001562 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693001563 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693001564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001565 Coenzyme A binding pocket [chemical binding]; other site 545693001566 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 545693001567 putative active site [active] 545693001568 catalytic triad [active] 545693001569 putative dimer interface [polypeptide binding]; other site 545693001570 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 545693001571 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 545693001572 amphipathic channel; other site 545693001573 Asn-Pro-Ala signature motifs; other site 545693001574 glycerol kinase; Provisional; Region: glpK; PRK00047 545693001575 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 545693001576 N- and C-terminal domain interface [polypeptide binding]; other site 545693001577 active site 545693001578 MgATP binding site [chemical binding]; other site 545693001579 catalytic site [active] 545693001580 metal binding site [ion binding]; metal-binding site 545693001581 glycerol binding site [chemical binding]; other site 545693001582 homotetramer interface [polypeptide binding]; other site 545693001583 homodimer interface [polypeptide binding]; other site 545693001584 FBP binding site [chemical binding]; other site 545693001585 protein IIAGlc interface [polypeptide binding]; other site 545693001586 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 545693001587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693001588 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 545693001589 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 545693001590 active site 545693001591 substrate binding site [chemical binding]; other site 545693001592 metal binding site [ion binding]; metal-binding site 545693001593 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 545693001594 YhdB-like protein; Region: YhdB; pfam14148 545693001595 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 545693001596 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 545693001597 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693001598 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693001599 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 545693001600 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 545693001601 putative NADP binding site [chemical binding]; other site 545693001602 putative dimer interface [polypeptide binding]; other site 545693001603 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 545693001604 active site 545693001605 dimerization interface [polypeptide binding]; other site 545693001606 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693001607 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 545693001608 Walker A/P-loop; other site 545693001609 ATP binding site [chemical binding]; other site 545693001610 Q-loop/lid; other site 545693001611 ABC transporter signature motif; other site 545693001612 Walker B; other site 545693001613 D-loop; other site 545693001614 H-loop/switch region; other site 545693001615 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693001616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001617 dimer interface [polypeptide binding]; other site 545693001618 conserved gate region; other site 545693001619 putative PBP binding loops; other site 545693001620 ABC-ATPase subunit interface; other site 545693001621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693001622 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693001623 substrate binding pocket [chemical binding]; other site 545693001624 membrane-bound complex binding site; other site 545693001625 hinge residues; other site 545693001626 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 545693001627 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 545693001628 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 545693001629 thiamine phosphate binding site [chemical binding]; other site 545693001630 active site 545693001631 pyrophosphate binding site [ion binding]; other site 545693001632 FAD dependent oxidoreductase; Region: DAO; pfam01266 545693001633 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 545693001634 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 545693001635 thiS-thiF/thiG interaction site; other site 545693001636 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 545693001637 ThiS interaction site; other site 545693001638 putative active site [active] 545693001639 tetramer interface [polypeptide binding]; other site 545693001640 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 545693001641 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 545693001642 ATP binding site [chemical binding]; other site 545693001643 substrate interface [chemical binding]; other site 545693001644 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 545693001645 dimer interface [polypeptide binding]; other site 545693001646 substrate binding site [chemical binding]; other site 545693001647 ATP binding site [chemical binding]; other site 545693001648 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693001649 catalytic core [active] 545693001650 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 545693001651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001653 NAD(P) binding site [chemical binding]; other site 545693001654 active site 545693001655 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693001656 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693001657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693001658 Transporter associated domain; Region: CorC_HlyC; smart01091 545693001659 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693001660 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 545693001661 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693001662 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 545693001663 Walker A/P-loop; other site 545693001664 ATP binding site [chemical binding]; other site 545693001665 Q-loop/lid; other site 545693001666 ABC transporter signature motif; other site 545693001667 Walker B; other site 545693001668 D-loop; other site 545693001669 H-loop/switch region; other site 545693001670 TOBE domain; Region: TOBE_2; pfam08402 545693001671 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693001672 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693001673 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693001674 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693001675 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693001676 hypothetical protein; Provisional; Region: PRK13676 545693001677 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 545693001678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001679 active site 545693001680 motif I; other site 545693001681 motif II; other site 545693001682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001683 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693001684 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 545693001685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693001686 FeS/SAM binding site; other site 545693001687 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 545693001688 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 545693001689 dimer interface [polypeptide binding]; other site 545693001690 acyl-activating enzyme (AAE) consensus motif; other site 545693001691 putative active site [active] 545693001692 AMP binding site [chemical binding]; other site 545693001693 putative CoA binding site [chemical binding]; other site 545693001694 enoyl-CoA hydratase; Provisional; Region: PRK07659 545693001695 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693001696 substrate binding site [chemical binding]; other site 545693001697 oxyanion hole (OAH) forming residues; other site 545693001698 trimer interface [polypeptide binding]; other site 545693001699 histone-like DNA-binding protein HU; Region: HU; cd13831 545693001700 dimer interface [polypeptide binding]; other site 545693001701 DNA binding site [nucleotide binding] 545693001702 YhzD-like protein; Region: YhzD; pfam14120 545693001703 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 545693001704 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 545693001705 Walker A/P-loop; other site 545693001706 ATP binding site [chemical binding]; other site 545693001707 Q-loop/lid; other site 545693001708 ABC transporter signature motif; other site 545693001709 Walker B; other site 545693001710 D-loop; other site 545693001711 H-loop/switch region; other site 545693001712 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 545693001713 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693001714 ABC-2 type transporter; Region: ABC2_membrane; cl17235 545693001715 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 545693001716 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 545693001717 generic binding surface II; other site 545693001718 generic binding surface I; other site 545693001719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693001720 Zn2+ binding site [ion binding]; other site 545693001721 Mg2+ binding site [ion binding]; other site 545693001722 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 545693001723 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 545693001724 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 545693001725 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 545693001726 protease production transcriptional regulator, frameshift 545693001727 YtxH-like protein; Region: YtxH; cl02079 545693001728 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 545693001729 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 545693001730 homodimer interface [polypeptide binding]; other site 545693001731 substrate-cofactor binding pocket; other site 545693001732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001733 catalytic residue [active] 545693001734 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693001735 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 545693001736 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 545693001737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001738 Coenzyme A binding pocket [chemical binding]; other site 545693001739 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 545693001740 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 545693001741 catalytic triad [active] 545693001742 catalytic triad [active] 545693001743 oxyanion hole [active] 545693001744 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 545693001745 HIT family signature motif; other site 545693001746 catalytic residue [active] 545693001747 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693001748 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693001749 Walker A/P-loop; other site 545693001750 ATP binding site [chemical binding]; other site 545693001751 Q-loop/lid; other site 545693001752 ABC transporter signature motif; other site 545693001753 Walker B; other site 545693001754 D-loop; other site 545693001755 H-loop/switch region; other site 545693001756 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 545693001757 EcsC protein family; Region: EcsC; pfam12787 545693001758 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693001759 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 545693001760 metal binding site [ion binding]; metal-binding site 545693001761 dimer interface [polypeptide binding]; other site 545693001762 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 545693001763 active site 545693001764 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693001765 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 545693001766 Transglycosylase; Region: Transgly; pfam00912 545693001767 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693001768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693001769 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 545693001770 substrate binding site [chemical binding]; other site 545693001771 active site 545693001772 ferrochelatase; Provisional; Region: PRK12435 545693001773 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 545693001774 C-terminal domain interface [polypeptide binding]; other site 545693001775 active site 545693001776 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 545693001777 active site 545693001778 N-terminal domain interface [polypeptide binding]; other site 545693001779 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 545693001780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 545693001781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693001782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693001783 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693001784 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 545693001785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693001786 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693001787 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 545693001788 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 545693001789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001790 dimerization interface [polypeptide binding]; other site 545693001791 Histidine kinase; Region: His_kinase; pfam06580 545693001792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001793 ATP binding site [chemical binding]; other site 545693001794 Mg2+ binding site [ion binding]; other site 545693001795 G-X-G motif; other site 545693001796 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 545693001797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693001798 active site 545693001799 phosphorylation site [posttranslational modification] 545693001800 intermolecular recognition site; other site 545693001801 dimerization interface [polypeptide binding]; other site 545693001802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693001803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693001804 YhfH-like protein; Region: YhfH; pfam14149 545693001805 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 545693001806 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 545693001807 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 545693001808 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 545693001809 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 545693001810 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 545693001811 acyl-activating enzyme (AAE) consensus motif; other site 545693001812 putative AMP binding site [chemical binding]; other site 545693001813 putative active site [active] 545693001814 putative CoA binding site [chemical binding]; other site 545693001815 enoyl-CoA hydratase; Provisional; Region: PRK07657 545693001816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693001817 substrate binding site [chemical binding]; other site 545693001818 oxyanion hole (OAH) forming residues; other site 545693001819 trimer interface [polypeptide binding]; other site 545693001820 Peptidase family M48; Region: Peptidase_M48; pfam01435 545693001821 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 545693001822 tetramer interface [polypeptide binding]; other site 545693001823 active site 545693001824 Mg2+/Mn2+ binding site [ion binding]; other site 545693001825 IDEAL domain; Region: IDEAL; pfam08858 545693001826 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 545693001827 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 545693001828 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 545693001829 Uncharacterized conserved protein [Function unknown]; Region: COG0398 545693001830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693001831 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693001832 NAD(P) binding site [chemical binding]; other site 545693001833 homotetramer interface [polypeptide binding]; other site 545693001834 homodimer interface [polypeptide binding]; other site 545693001835 active site 545693001836 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 545693001837 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 545693001838 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 545693001839 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 545693001840 Part of AAA domain; Region: AAA_19; pfam13245 545693001841 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 545693001842 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 545693001843 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 545693001844 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 545693001845 active site 545693001846 metal binding site [ion binding]; metal-binding site 545693001847 DNA binding site [nucleotide binding] 545693001848 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 545693001849 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 545693001850 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 545693001851 Walker A/P-loop; other site 545693001852 ATP binding site [chemical binding]; other site 545693001853 Q-loop/lid; other site 545693001854 ABC transporter signature motif; other site 545693001855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693001856 ABC transporter signature motif; other site 545693001857 Walker B; other site 545693001858 D-loop; other site 545693001859 H-loop/switch region; other site 545693001860 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 545693001861 active site 545693001862 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693001863 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 545693001864 Spore germination protein GerPC; Region: GerPC; pfam10737 545693001865 Spore germination GerPB; Region: GerPB; pfam10803 545693001866 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693001867 Predicted membrane protein [Function unknown]; Region: COG2311 545693001868 Protein of unknown function (DUF418); Region: DUF418; pfam04235 545693001869 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 545693001870 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 545693001871 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 545693001872 active site 545693001873 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 545693001874 dimer interface [polypeptide binding]; other site 545693001875 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 545693001876 Ligand Binding Site [chemical binding]; other site 545693001877 Molecular Tunnel; other site 545693001878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693001879 phytoene desaturase; Region: crtI_fam; TIGR02734 545693001880 phytoene desaturase; Region: crtI_fam; TIGR02734 545693001881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693001882 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 545693001883 active site lid residues [active] 545693001884 substrate binding pocket [chemical binding]; other site 545693001885 catalytic residues [active] 545693001886 substrate-Mg2+ binding site; other site 545693001887 aspartate-rich region 1; other site 545693001888 aspartate-rich region 2; other site 545693001889 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 545693001890 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 545693001891 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 545693001892 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 545693001893 active site 545693001894 catalytic site [active] 545693001895 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 545693001896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693001897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693001898 DNA binding site [nucleotide binding] 545693001899 domain linker motif; other site 545693001900 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 545693001901 putative dimerization interface [polypeptide binding]; other site 545693001902 putative ligand binding site [chemical binding]; other site 545693001903 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 545693001904 Glutamate binding site [chemical binding]; other site 545693001905 homodimer interface [polypeptide binding]; other site 545693001906 NAD binding site [chemical binding]; other site 545693001907 catalytic residues [active] 545693001908 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693001909 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693001910 inhibitor-cofactor binding pocket; inhibition site 545693001911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001912 catalytic residue [active] 545693001913 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 545693001914 putative metal binding site [ion binding]; other site 545693001915 putative dimer interface [polypeptide binding]; other site 545693001916 S-methylmethionine transporter; Provisional; Region: PRK11387 545693001917 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693001918 PAS domain; Region: PAS_9; pfam13426 545693001919 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693001920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693001921 Walker A motif; other site 545693001922 ATP binding site [chemical binding]; other site 545693001923 Walker B motif; other site 545693001924 arginine finger; other site 545693001925 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 545693001926 oxidoreductase; Provisional; Region: PRK06128 545693001927 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 545693001928 NAD binding site [chemical binding]; other site 545693001929 metal binding site [ion binding]; metal-binding site 545693001930 active site 545693001931 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 545693001932 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 545693001933 S1 domain; Region: S1_2; pfam13509 545693001934 EDD domain protein, DegV family; Region: DegV; TIGR00762 545693001935 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693001936 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693001937 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693001938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001939 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693001940 active site 545693001941 motif I; other site 545693001942 motif II; other site 545693001943 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693001944 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 545693001945 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693001946 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 545693001947 ligand binding site [chemical binding]; other site 545693001948 flexible hinge region; other site 545693001949 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 545693001950 putative switch regulator; other site 545693001951 non-specific DNA interactions [nucleotide binding]; other site 545693001952 DNA binding site [nucleotide binding] 545693001953 sequence specific DNA binding site [nucleotide binding]; other site 545693001954 putative cAMP binding site [chemical binding]; other site 545693001955 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 545693001956 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 545693001957 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 545693001958 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 545693001959 heterotetramer interface [polypeptide binding]; other site 545693001960 active site pocket [active] 545693001961 cleavage site 545693001962 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 545693001963 nucleotide binding site [chemical binding]; other site 545693001964 N-acetyl-L-glutamate binding site [chemical binding]; other site 545693001965 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693001966 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693001967 inhibitor-cofactor binding pocket; inhibition site 545693001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001969 catalytic residue [active] 545693001970 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 545693001971 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 545693001972 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 545693001973 catalytic site [active] 545693001974 subunit interface [polypeptide binding]; other site 545693001975 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 545693001976 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693001977 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 545693001978 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 545693001979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693001980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 545693001981 ornithine carbamoyltransferase; Provisional; Region: PRK00779 545693001982 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 545693001983 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 545693001984 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 545693001985 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 545693001986 NAD(P) binding site [chemical binding]; other site 545693001987 putative active site [active] 545693001988 YjzC-like protein; Region: YjzC; pfam14168 545693001989 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 545693001990 Clp amino terminal domain; Region: Clp_N; pfam02861 545693001991 Clp amino terminal domain; Region: Clp_N; pfam02861 545693001992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693001993 Walker A motif; other site 545693001994 ATP binding site [chemical binding]; other site 545693001995 Walker B motif; other site 545693001996 arginine finger; other site 545693001997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693001998 Walker A motif; other site 545693001999 ATP binding site [chemical binding]; other site 545693002000 Walker B motif; other site 545693002001 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 545693002002 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 545693002003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693002004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693002005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693002006 galactokinase; Provisional; Region: PRK05322 545693002007 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 545693002008 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 545693002009 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 545693002010 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 545693002011 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 545693002012 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 545693002013 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 545693002014 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693002015 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 545693002016 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 545693002017 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693002018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002019 NAD(P) binding site [chemical binding]; other site 545693002020 active site 545693002021 ComZ; Region: ComZ; pfam10815 545693002022 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 545693002023 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 545693002024 dimer interface [polypeptide binding]; other site 545693002025 active site 545693002026 CoA binding pocket [chemical binding]; other site 545693002027 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 545693002028 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693002029 dimer interface [polypeptide binding]; other site 545693002030 active site 545693002031 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 545693002032 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693002033 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693002034 Walker A/P-loop; other site 545693002035 ATP binding site [chemical binding]; other site 545693002036 Q-loop/lid; other site 545693002037 ABC transporter signature motif; other site 545693002038 Walker B; other site 545693002039 D-loop; other site 545693002040 H-loop/switch region; other site 545693002041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693002042 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 545693002043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693002044 Walker A/P-loop; other site 545693002045 ATP binding site [chemical binding]; other site 545693002046 Q-loop/lid; other site 545693002047 ABC transporter signature motif; other site 545693002048 Walker B; other site 545693002049 D-loop; other site 545693002050 H-loop/switch region; other site 545693002051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693002052 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693002053 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 545693002054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693002055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002056 dimer interface [polypeptide binding]; other site 545693002057 conserved gate region; other site 545693002058 putative PBP binding loops; other site 545693002059 ABC-ATPase subunit interface; other site 545693002060 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693002061 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693002062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002063 dimer interface [polypeptide binding]; other site 545693002064 conserved gate region; other site 545693002065 putative PBP binding loops; other site 545693002066 ABC-ATPase subunit interface; other site 545693002067 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 545693002068 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 545693002069 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 545693002070 active site 545693002071 HIGH motif; other site 545693002072 dimer interface [polypeptide binding]; other site 545693002073 KMSKS motif; other site 545693002074 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 545693002075 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 545693002076 peptide binding site [polypeptide binding]; other site 545693002077 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693002078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002079 dimer interface [polypeptide binding]; other site 545693002080 conserved gate region; other site 545693002081 putative PBP binding loops; other site 545693002082 ABC-ATPase subunit interface; other site 545693002083 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693002084 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693002085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002086 dimer interface [polypeptide binding]; other site 545693002087 conserved gate region; other site 545693002088 putative PBP binding loops; other site 545693002089 ABC-ATPase subunit interface; other site 545693002090 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693002091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693002092 Walker A/P-loop; other site 545693002093 ATP binding site [chemical binding]; other site 545693002094 Q-loop/lid; other site 545693002095 ABC transporter signature motif; other site 545693002096 Walker B; other site 545693002097 D-loop; other site 545693002098 H-loop/switch region; other site 545693002099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693002100 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 545693002101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693002102 Walker A/P-loop; other site 545693002103 ATP binding site [chemical binding]; other site 545693002104 Q-loop/lid; other site 545693002105 ABC transporter signature motif; other site 545693002106 Walker B; other site 545693002107 D-loop; other site 545693002108 H-loop/switch region; other site 545693002109 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693002110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002111 Coenzyme A binding pocket [chemical binding]; other site 545693002112 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693002113 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 545693002114 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 545693002115 Spore germination protein; Region: Spore_permease; cl17796 545693002116 Na binding site [ion binding]; other site 545693002117 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 545693002118 putative catalytic residues [active] 545693002119 thiol/disulfide switch; other site 545693002120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693002122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693002123 dimerization interface [polypeptide binding]; other site 545693002124 Malonate transporter MadL subunit; Region: MadL; cl04273 545693002125 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 545693002126 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 545693002127 adaptor protein; Provisional; Region: PRK02315 545693002128 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 545693002129 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693002130 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693002131 putative active site [active] 545693002132 catalytic site [active] 545693002133 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693002134 putative active site [active] 545693002135 catalytic site [active] 545693002136 Competence protein CoiA-like family; Region: CoiA; cl11541 545693002137 oligoendopeptidase F; Region: pepF; TIGR00181 545693002138 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 545693002139 active site 545693002140 Zn binding site [ion binding]; other site 545693002141 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 545693002142 catalytic residues [active] 545693002143 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 545693002144 apolar tunnel; other site 545693002145 heme binding site [chemical binding]; other site 545693002146 dimerization interface [polypeptide binding]; other site 545693002147 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 545693002148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 545693002149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 545693002150 catalytic residue [active] 545693002151 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 545693002152 putative active site [active] 545693002153 putative metal binding residues [ion binding]; other site 545693002154 signature motif; other site 545693002155 putative triphosphate binding site [ion binding]; other site 545693002156 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 545693002157 synthetase active site [active] 545693002158 NTP binding site [chemical binding]; other site 545693002159 metal binding site [ion binding]; metal-binding site 545693002160 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 545693002161 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 545693002162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693002163 RNA binding surface [nucleotide binding]; other site 545693002164 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 545693002165 active site 545693002166 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 545693002167 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693002168 active site 545693002169 metal binding site [ion binding]; metal-binding site 545693002170 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 545693002171 MgtE intracellular N domain; Region: MgtE_N; pfam03448 545693002172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 545693002173 Divalent cation transporter; Region: MgtE; pfam01769 545693002174 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 545693002175 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 545693002176 TrkA-N domain; Region: TrkA_N; pfam02254 545693002177 TrkA-C domain; Region: TrkA_C; pfam02080 545693002178 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 545693002179 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 545693002180 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693002181 Sec1 family; Region: Sec1; cl15415 545693002182 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 545693002183 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 545693002184 Peptidase family M48; Region: Peptidase_M48; cl12018 545693002185 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 545693002186 Part of AAA domain; Region: AAA_19; pfam13245 545693002187 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 545693002188 Predicted membrane protein [Function unknown]; Region: COG2323 545693002189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002190 Coenzyme A binding pocket [chemical binding]; other site 545693002191 hypothetical protein; Provisional; Region: PRK13679 545693002192 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 545693002193 Putative esterase; Region: Esterase; pfam00756 545693002194 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 545693002195 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 545693002196 tetramer interfaces [polypeptide binding]; other site 545693002197 binuclear metal-binding site [ion binding]; other site 545693002198 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693002199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002200 Coenzyme A binding pocket [chemical binding]; other site 545693002201 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002202 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693002203 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693002204 putative active site [active] 545693002205 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 545693002206 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693002207 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 545693002208 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 545693002209 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 545693002210 N- and C-terminal domain interface [polypeptide binding]; other site 545693002211 active site 545693002212 catalytic site [active] 545693002213 metal binding site [ion binding]; metal-binding site 545693002214 carbohydrate binding site [chemical binding]; other site 545693002215 ATP binding site [chemical binding]; other site 545693002216 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 545693002217 Na binding site [ion binding]; other site 545693002218 putative substrate binding site [chemical binding]; other site 545693002219 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693002220 GntP family permease; Region: GntP_permease; pfam02447 545693002221 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 545693002222 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693002223 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693002224 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693002225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693002226 putative DNA binding site [nucleotide binding]; other site 545693002227 putative Zn2+ binding site [ion binding]; other site 545693002228 AsnC family; Region: AsnC_trans_reg; pfam01037 545693002229 N-acetyltransferase; Region: Acetyltransf_2; cl00949 545693002230 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693002231 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 545693002232 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693002233 ATP binding site [chemical binding]; other site 545693002234 Mg++ binding site [ion binding]; other site 545693002235 motif III; other site 545693002236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693002237 nucleotide binding region [chemical binding]; other site 545693002238 ATP-binding site [chemical binding]; other site 545693002239 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 545693002240 RNA binding site [nucleotide binding]; other site 545693002241 Class I aldolases; Region: Aldolase_Class_I; cd00945 545693002242 catalytic residue [active] 545693002243 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 545693002244 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693002245 Heat induced stress protein YflT; Region: YflT; pfam11181 545693002246 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693002247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693002248 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 545693002249 WHG domain; Region: WHG; pfam13305 545693002250 HTH domain; Region: HTH_11; pfam08279 545693002251 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693002252 Mga helix-turn-helix domain; Region: Mga; pfam05043 545693002253 PRD domain; Region: PRD; pfam00874 545693002254 PRD domain; Region: PRD; pfam00874 545693002255 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693002256 active site 545693002257 P-loop; other site 545693002258 phosphorylation site [posttranslational modification] 545693002259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693002260 active site 545693002261 phosphorylation site [posttranslational modification] 545693002262 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 545693002263 active site 545693002264 P-loop; other site 545693002265 phosphorylation site [posttranslational modification] 545693002266 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 545693002267 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 545693002268 methionine cluster; other site 545693002269 active site 545693002270 phosphorylation site [posttranslational modification] 545693002271 metal binding site [ion binding]; metal-binding site 545693002272 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 545693002273 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 545693002274 NAD binding site [chemical binding]; other site 545693002275 sugar binding site [chemical binding]; other site 545693002276 divalent metal binding site [ion binding]; other site 545693002277 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693002278 dimer interface [polypeptide binding]; other site 545693002279 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 545693002280 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 545693002281 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 545693002282 Histidine kinase; Region: His_kinase; pfam06580 545693002283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002284 ATP binding site [chemical binding]; other site 545693002285 Mg2+ binding site [ion binding]; other site 545693002286 G-X-G motif; other site 545693002287 two-component response regulator; Provisional; Region: PRK14084 545693002288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002289 active site 545693002290 phosphorylation site [posttranslational modification] 545693002291 intermolecular recognition site; other site 545693002292 dimerization interface [polypeptide binding]; other site 545693002293 LytTr DNA-binding domain; Region: LytTR; pfam04397 545693002294 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 545693002295 antiholin-like protein LrgB; Provisional; Region: PRK04288 545693002296 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 545693002297 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693002298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693002299 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 545693002300 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693002301 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 545693002302 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 545693002303 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 545693002304 [4Fe-4S] binding site [ion binding]; other site 545693002305 molybdopterin cofactor binding site; other site 545693002306 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 545693002307 molybdopterin cofactor binding site; other site 545693002308 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 545693002309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002310 putative substrate translocation pore; other site 545693002311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693002312 S-adenosylmethionine binding site [chemical binding]; other site 545693002313 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 545693002314 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693002315 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 545693002316 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693002317 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 545693002318 tetramer interface [polypeptide binding]; other site 545693002319 active site 545693002320 Mg2+/Mn2+ binding site [ion binding]; other site 545693002321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693002322 active site 545693002323 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693002324 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 545693002325 PYR/PP interface [polypeptide binding]; other site 545693002326 dimer interface [polypeptide binding]; other site 545693002327 TPP binding site [chemical binding]; other site 545693002328 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 545693002329 TPP-binding site [chemical binding]; other site 545693002330 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 545693002331 active site 545693002332 metal-binding site 545693002333 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 545693002334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693002335 catalytic residue [active] 545693002336 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 545693002337 nudix motif; other site 545693002338 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 545693002339 acetolactate synthase; Reviewed; Region: PRK08617 545693002340 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693002341 PYR/PP interface [polypeptide binding]; other site 545693002342 dimer interface [polypeptide binding]; other site 545693002343 TPP binding site [chemical binding]; other site 545693002344 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693002345 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 545693002346 TPP-binding site [chemical binding]; other site 545693002347 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 545693002348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693002349 dimerization interface [polypeptide binding]; other site 545693002350 putative DNA binding site [nucleotide binding]; other site 545693002351 putative Zn2+ binding site [ion binding]; other site 545693002352 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693002353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002354 putative substrate translocation pore; other site 545693002355 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 545693002356 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 545693002357 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 545693002358 Coenzyme A transferase; Region: CoA_trans; cl17247 545693002359 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 545693002360 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 545693002361 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 545693002362 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 545693002363 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098; cl07913 545693002364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002365 active site 545693002366 phosphorylation site [posttranslational modification] 545693002367 intermolecular recognition site; other site 545693002368 dimerization interface [polypeptide binding]; other site 545693002369 YcbB domain; Region: YcbB; pfam08664 545693002370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693002371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002372 ATP binding site [chemical binding]; other site 545693002373 Mg2+ binding site [ion binding]; other site 545693002374 G-X-G motif; other site 545693002375 glutaminase; Reviewed; Region: PRK12357 545693002376 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 545693002377 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 545693002378 Na binding site [ion binding]; other site 545693002379 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 545693002380 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 545693002381 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693002382 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693002383 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 545693002384 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 545693002385 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 545693002386 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 545693002387 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 545693002388 iron-sulfur cluster [ion binding]; other site 545693002389 [2Fe-2S] cluster binding site [ion binding]; other site 545693002390 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 545693002391 hydrophobic ligand binding site; other site 545693002392 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 545693002393 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 545693002394 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 545693002395 Walker A/P-loop; other site 545693002396 ATP binding site [chemical binding]; other site 545693002397 Q-loop/lid; other site 545693002398 ABC transporter signature motif; other site 545693002399 Walker B; other site 545693002400 D-loop; other site 545693002401 H-loop/switch region; other site 545693002402 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693002403 homodimer interface [polypeptide binding]; other site 545693002404 substrate-cofactor binding pocket; other site 545693002405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002406 catalytic residue [active] 545693002407 Yip1 domain; Region: Yip1; pfam04893 545693002408 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 545693002409 HlyD family secretion protein; Region: HlyD_3; pfam13437 545693002410 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693002411 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 545693002412 Walker A/P-loop; other site 545693002413 ATP binding site [chemical binding]; other site 545693002414 Q-loop/lid; other site 545693002415 ABC transporter signature motif; other site 545693002416 Walker B; other site 545693002417 D-loop; other site 545693002418 H-loop/switch region; other site 545693002419 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693002420 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 545693002421 FtsX-like permease family; Region: FtsX; pfam02687 545693002422 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 545693002423 Subtilase family; Region: Peptidase_S8; pfam00082 545693002424 active site 545693002425 catalytic residues [active] 545693002426 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 545693002427 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 545693002428 substrate binding pocket [chemical binding]; other site 545693002429 dimer interface [polypeptide binding]; other site 545693002430 inhibitor binding site; inhibition site 545693002431 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 545693002432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693002433 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 545693002434 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 545693002435 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693002436 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 545693002437 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 545693002438 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 545693002439 S-methylmethionine transporter; Provisional; Region: PRK11387 545693002440 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693002441 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 545693002442 AAA domain; Region: AAA_26; pfam13500 545693002443 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 545693002444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693002445 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693002446 inhibitor-cofactor binding pocket; inhibition site 545693002447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002448 catalytic residue [active] 545693002449 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 545693002450 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 545693002451 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 545693002452 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693002453 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 545693002454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693002455 putative active site [active] 545693002456 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 545693002457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002458 ATP binding site [chemical binding]; other site 545693002459 Mg2+ binding site [ion binding]; other site 545693002460 G-X-G motif; other site 545693002461 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 545693002462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002463 active site 545693002464 phosphorylation site [posttranslational modification] 545693002465 intermolecular recognition site; other site 545693002466 dimerization interface [polypeptide binding]; other site 545693002467 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 545693002468 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 545693002469 Sugar transport protein; Region: Sugar_transport; pfam06800 545693002470 glucose-1-dehydrogenase; Provisional; Region: PRK08936 545693002471 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 545693002472 NAD binding site [chemical binding]; other site 545693002473 homodimer interface [polypeptide binding]; other site 545693002474 active site 545693002475 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 545693002476 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 545693002477 ApbE family; Region: ApbE; pfam02424 545693002478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693002479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693002480 non-specific DNA binding site [nucleotide binding]; other site 545693002481 salt bridge; other site 545693002482 sequence-specific DNA binding site [nucleotide binding]; other site 545693002483 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693002484 Sulfatase; Region: Sulfatase; pfam00884 545693002485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693002486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002487 Coenzyme A binding pocket [chemical binding]; other site 545693002488 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693002489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693002490 DNA-binding site [nucleotide binding]; DNA binding site 545693002491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693002492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002493 homodimer interface [polypeptide binding]; other site 545693002494 catalytic residue [active] 545693002495 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 545693002496 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 545693002497 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693002498 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 545693002499 Citrate transporter; Region: CitMHS; pfam03600 545693002500 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693002501 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 545693002502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693002503 putative active site [active] 545693002504 heme pocket [chemical binding]; other site 545693002505 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 545693002506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002507 ATP binding site [chemical binding]; other site 545693002508 Mg2+ binding site [ion binding]; other site 545693002509 G-X-G motif; other site 545693002510 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 545693002511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002512 active site 545693002513 phosphorylation site [posttranslational modification] 545693002514 intermolecular recognition site; other site 545693002515 dimerization interface [polypeptide binding]; other site 545693002516 Transcriptional regulator; Region: CitT; pfam12431 545693002517 HTH domain; Region: HTH_11; cl17392 545693002518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 545693002519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693002521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693002522 dimerization interface [polypeptide binding]; other site 545693002523 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 545693002524 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 545693002525 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 545693002526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693002527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693002528 S-adenosylmethionine binding site [chemical binding]; other site 545693002529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 545693002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002531 dimer interface [polypeptide binding]; other site 545693002532 conserved gate region; other site 545693002533 putative PBP binding loops; other site 545693002534 ABC-ATPase subunit interface; other site 545693002535 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 545693002536 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 545693002537 Walker A/P-loop; other site 545693002538 ATP binding site [chemical binding]; other site 545693002539 Q-loop/lid; other site 545693002540 ABC transporter signature motif; other site 545693002541 Walker B; other site 545693002542 D-loop; other site 545693002543 H-loop/switch region; other site 545693002544 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 545693002545 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 545693002546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693002547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693002548 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 545693002549 tetramerization interface [polypeptide binding]; other site 545693002550 NAD(P) binding site [chemical binding]; other site 545693002551 catalytic residues [active] 545693002552 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693002553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693002554 inhibitor-cofactor binding pocket; inhibition site 545693002555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002556 catalytic residue [active] 545693002557 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 545693002558 oligomer interface [polypeptide binding]; other site 545693002559 putative active site [active] 545693002560 Mn binding site [ion binding]; other site 545693002561 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693002562 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693002563 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 545693002564 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 545693002565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693002566 motif II; other site 545693002567 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 545693002568 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 545693002569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002570 dimer interface [polypeptide binding]; other site 545693002571 conserved gate region; other site 545693002572 putative PBP binding loops; other site 545693002573 ABC-ATPase subunit interface; other site 545693002574 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 545693002575 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 545693002576 Walker A/P-loop; other site 545693002577 ATP binding site [chemical binding]; other site 545693002578 Q-loop/lid; other site 545693002579 ABC transporter signature motif; other site 545693002580 Walker B; other site 545693002581 D-loop; other site 545693002582 H-loop/switch region; other site 545693002583 NIL domain; Region: NIL; pfam09383 545693002584 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693002585 active site 545693002586 non-prolyl cis peptide bond; other site 545693002587 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 545693002588 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693002589 active site 545693002590 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693002591 active site 545693002592 dimer interface [polypeptide binding]; other site 545693002593 non-prolyl cis peptide bond; other site 545693002594 insertion regions; other site 545693002595 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 545693002596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693002597 active site 545693002598 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 545693002599 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 545693002600 siderophore binding site; other site 545693002601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693002602 ABC-ATPase subunit interface; other site 545693002603 dimer interface [polypeptide binding]; other site 545693002604 putative PBP binding regions; other site 545693002605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693002606 ABC-ATPase subunit interface; other site 545693002607 dimer interface [polypeptide binding]; other site 545693002608 putative PBP binding regions; other site 545693002609 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693002610 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693002611 endonuclease VIII; Provisional; Region: PRK10445 545693002612 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 545693002613 DNA binding site [nucleotide binding] 545693002614 catalytic residue [active] 545693002615 putative catalytic residues [active] 545693002616 H2TH interface [polypeptide binding]; other site 545693002617 intercalation triad [nucleotide binding]; other site 545693002618 substrate specificity determining residue; other site 545693002619 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 545693002620 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 545693002621 active site 2 [active] 545693002622 active site 1 [active] 545693002623 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 545693002624 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002625 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693002626 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693002627 putative active site [active] 545693002628 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693002629 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 545693002630 active site turn [active] 545693002631 phosphorylation site [posttranslational modification] 545693002632 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693002633 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 545693002634 acetylornithine deacetylase; Validated; Region: PRK08596 545693002635 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 545693002636 metal binding site [ion binding]; metal-binding site 545693002637 Putative transcription activator [Transcription]; Region: TenA; COG0819 545693002638 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693002639 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 545693002640 Walker A/P-loop; other site 545693002641 ATP binding site [chemical binding]; other site 545693002642 Q-loop/lid; other site 545693002643 ABC transporter signature motif; other site 545693002644 Walker B; other site 545693002645 D-loop; other site 545693002646 H-loop/switch region; other site 545693002647 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693002648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002649 dimer interface [polypeptide binding]; other site 545693002650 conserved gate region; other site 545693002651 putative PBP binding loops; other site 545693002652 ABC-ATPase subunit interface; other site 545693002653 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 545693002654 NMT1/THI5 like; Region: NMT1; pfam09084 545693002655 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 545693002656 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002657 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 545693002658 tetramer interface [polypeptide binding]; other site 545693002659 active site 545693002660 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 545693002661 active site 545693002662 dimer interface [polypeptide binding]; other site 545693002663 magnesium binding site [ion binding]; other site 545693002664 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 545693002665 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693002666 Virus attachment protein p12 family; Region: P12; pfam12669 545693002667 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 545693002668 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 545693002669 G1 box; other site 545693002670 GTP/Mg2+ binding site [chemical binding]; other site 545693002671 Switch I region; other site 545693002672 G2 box; other site 545693002673 G3 box; other site 545693002674 Switch II region; other site 545693002675 G4 box; other site 545693002676 G5 box; other site 545693002677 Nucleoside recognition; Region: Gate; pfam07670 545693002678 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 545693002679 Nucleoside recognition; Region: Gate; pfam07670 545693002680 FeoA domain; Region: FeoA; pfam04023 545693002681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693002682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002683 Coenzyme A binding pocket [chemical binding]; other site 545693002684 Predicted membrane protein [Function unknown]; Region: COG1511 545693002685 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693002686 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693002687 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693002688 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 545693002689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693002690 S-adenosylmethionine binding site [chemical binding]; other site 545693002691 TEA/ATTS domain family; Region: TEA; cl02603 545693002692 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 545693002693 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 545693002694 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 545693002695 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 545693002696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693002697 dimerization interface [polypeptide binding]; other site 545693002698 putative DNA binding site [nucleotide binding]; other site 545693002699 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693002700 putative Zn2+ binding site [ion binding]; other site 545693002701 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 545693002702 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693002703 putative NAD(P) binding site [chemical binding]; other site 545693002704 substrate binding site [chemical binding]; other site 545693002705 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693002706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693002707 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 545693002708 Walker A/P-loop; other site 545693002709 ATP binding site [chemical binding]; other site 545693002710 Q-loop/lid; other site 545693002711 ABC transporter signature motif; other site 545693002712 Walker B; other site 545693002713 D-loop; other site 545693002714 H-loop/switch region; other site 545693002715 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693002716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693002717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693002718 Walker A/P-loop; other site 545693002719 ATP binding site [chemical binding]; other site 545693002720 Q-loop/lid; other site 545693002721 ABC transporter signature motif; other site 545693002722 Walker B; other site 545693002723 D-loop; other site 545693002724 H-loop/switch region; other site 545693002725 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 545693002726 Na binding site [ion binding]; other site 545693002727 Protein of unknown function, DUF485; Region: DUF485; pfam04341 545693002728 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693002729 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693002730 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 545693002731 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693002732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693002733 active site 545693002734 catalytic tetrad [active] 545693002735 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 545693002736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002737 NAD(P) binding site [chemical binding]; other site 545693002738 active site 545693002739 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693002740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693002741 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 545693002742 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693002743 carboxyltransferase (CT) interaction site; other site 545693002744 biotinylation site [posttranslational modification]; other site 545693002745 HlyD family secretion protein; Region: HlyD_3; pfam13437 545693002746 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693002747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002748 putative substrate translocation pore; other site 545693002749 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693002750 2-oxoglutarate dehydrogenase E2 component; Region: PLN02226 545693002751 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693002752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693002753 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693002754 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693002755 DNA binding site [nucleotide binding] 545693002756 domain linker motif; other site 545693002757 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 545693002758 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 545693002759 substrate binding site [chemical binding]; other site 545693002760 dimer interface [polypeptide binding]; other site 545693002761 ATP binding site [chemical binding]; other site 545693002762 D-ribose pyranase; Provisional; Region: PRK11797 545693002763 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 545693002764 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 545693002765 Walker A/P-loop; other site 545693002766 ATP binding site [chemical binding]; other site 545693002767 Q-loop/lid; other site 545693002768 ABC transporter signature motif; other site 545693002769 Walker B; other site 545693002770 D-loop; other site 545693002771 H-loop/switch region; other site 545693002772 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 545693002773 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 545693002774 TM-ABC transporter signature motif; other site 545693002775 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 545693002776 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 545693002777 ligand binding site [chemical binding]; other site 545693002778 dimerization interface [polypeptide binding]; other site 545693002779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 545693002780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 545693002781 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 545693002782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693002783 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 545693002784 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 545693002785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002787 dimer interface [polypeptide binding]; other site 545693002788 putative PBP binding loops; other site 545693002789 ABC-ATPase subunit interface; other site 545693002790 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002792 dimer interface [polypeptide binding]; other site 545693002793 conserved gate region; other site 545693002794 putative PBP binding loops; other site 545693002795 ABC-ATPase subunit interface; other site 545693002796 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693002797 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693002798 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 545693002799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002800 active site 545693002801 phosphorylation site [posttranslational modification] 545693002802 intermolecular recognition site; other site 545693002803 dimerization interface [polypeptide binding]; other site 545693002804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693002805 metal binding site [ion binding]; metal-binding site 545693002806 active site 545693002807 I-site; other site 545693002808 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693002809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002810 active site 545693002811 phosphorylation site [posttranslational modification] 545693002812 intermolecular recognition site; other site 545693002813 dimerization interface [polypeptide binding]; other site 545693002814 HEAT repeats; Region: HEAT_2; pfam13646 545693002815 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 545693002816 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 545693002817 DXD motif; other site 545693002818 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 545693002819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002820 active site 545693002821 phosphorylation site [posttranslational modification] 545693002822 intermolecular recognition site; other site 545693002823 dimerization interface [polypeptide binding]; other site 545693002824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693002825 dimerization interface [polypeptide binding]; other site 545693002826 GAF domain; Region: GAF_2; pfam13185 545693002827 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693002828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693002829 dimer interface [polypeptide binding]; other site 545693002830 phosphorylation site [posttranslational modification] 545693002831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002832 ATP binding site [chemical binding]; other site 545693002833 Mg2+ binding site [ion binding]; other site 545693002834 G-X-G motif; other site 545693002835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693002836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002837 active site 545693002838 phosphorylation site [posttranslational modification] 545693002839 intermolecular recognition site; other site 545693002840 dimerization interface [polypeptide binding]; other site 545693002841 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 545693002842 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693002843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693002844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693002845 catalytic core [active] 545693002846 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693002847 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693002848 inhibitor-cofactor binding pocket; inhibition site 545693002849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002850 catalytic residue [active] 545693002851 YKOF-related Family; Region: Ykof; pfam07615 545693002852 YKOF-related Family; Region: Ykof; pfam07615 545693002853 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 545693002854 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 545693002855 active site 545693002856 putative substrate binding pocket [chemical binding]; other site 545693002857 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693002858 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693002859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693002860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693002861 DNA binding site [nucleotide binding] 545693002862 domain linker motif; other site 545693002863 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 545693002864 putative dimerization interface [polypeptide binding]; other site 545693002865 putative ligand binding site [chemical binding]; other site 545693002866 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 545693002867 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 545693002868 ADP binding site [chemical binding]; other site 545693002869 magnesium binding site [ion binding]; other site 545693002870 putative shikimate binding site; other site 545693002871 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 545693002872 NAD(P) binding site [chemical binding]; other site 545693002873 catalytic residues [active] 545693002874 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 545693002875 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693002876 PYR/PP interface [polypeptide binding]; other site 545693002877 dimer interface [polypeptide binding]; other site 545693002878 TPP binding site [chemical binding]; other site 545693002879 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693002880 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 545693002881 TPP-binding site [chemical binding]; other site 545693002882 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 545693002883 active site 545693002884 catalytic residue [active] 545693002885 dimer interface [polypeptide binding]; other site 545693002886 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 545693002887 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 545693002888 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693002889 active site turn [active] 545693002890 phosphorylation site [posttranslational modification] 545693002891 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693002892 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 545693002893 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 545693002894 Ca binding site [ion binding]; other site 545693002895 active site 545693002896 catalytic site [active] 545693002897 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 545693002898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693002899 DNA-binding site [nucleotide binding]; DNA binding site 545693002900 UTRA domain; Region: UTRA; pfam07702 545693002901 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 545693002902 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 545693002903 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 545693002904 putative active site [active] 545693002905 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 545693002906 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 545693002907 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 545693002908 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 545693002909 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 545693002910 putative FMN binding site [chemical binding]; other site 545693002911 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 545693002912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693002914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693002915 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 545693002916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693002917 putative NAD(P) binding site [chemical binding]; other site 545693002918 substrate binding site [chemical binding]; other site 545693002919 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 545693002920 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 545693002921 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 545693002922 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 545693002923 shikimate binding site; other site 545693002924 NAD(P) binding site [chemical binding]; other site 545693002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002926 D-galactonate transporter; Region: 2A0114; TIGR00893 545693002927 putative substrate translocation pore; other site 545693002928 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 545693002929 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 545693002930 active site 545693002931 catalytic residues [active] 545693002932 metal binding site [ion binding]; metal-binding site 545693002933 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 545693002934 NAD(P) binding site [chemical binding]; other site 545693002935 catalytic residues [active] 545693002936 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693002937 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693002938 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 545693002939 cytosine deaminase; Provisional; Region: PRK05985 545693002940 active site 545693002941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693002942 DNA-binding site [nucleotide binding]; DNA binding site 545693002943 RNA-binding motif; other site 545693002944 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693002945 NAD binding site [chemical binding]; other site 545693002946 substrate binding site [chemical binding]; other site 545693002947 putative active site [active] 545693002948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693002949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693002950 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 545693002951 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 545693002952 dimer interface [polypeptide binding]; other site 545693002953 decamer (pentamer of dimers) interface [polypeptide binding]; other site 545693002954 catalytic triad [active] 545693002955 peroxidatic and resolving cysteines [active] 545693002956 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 545693002957 catalytic residues [active] 545693002958 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693002959 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693002960 DNA binding residues [nucleotide binding] 545693002961 YvrJ protein family; Region: YvrJ; pfam12841 545693002962 hypothetical protein; Provisional; Region: PRK14082 545693002963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693002964 metal binding site [ion binding]; metal-binding site 545693002965 active site 545693002966 I-site; other site 545693002967 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 545693002968 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 545693002969 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 545693002970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693002971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693002972 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 545693002973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693002974 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 545693002975 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 545693002976 putative active site [active] 545693002977 putative metal binding site [ion binding]; other site 545693002978 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 545693002979 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 545693002980 Staygreen protein; Region: Staygreen; pfam12638 545693002981 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 545693002982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693002983 active site 545693002984 motif I; other site 545693002985 motif II; other site 545693002986 CsbD-like; Region: CsbD; pfam05532 545693002987 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 545693002988 nudix motif; other site 545693002989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 545693002990 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002991 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693002992 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693002993 putative active site [active] 545693002994 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 545693002995 active site 545693002996 P-loop; other site 545693002997 phosphorylation site [posttranslational modification] 545693002998 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 545693002999 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 545693003000 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 545693003001 NAD binding site [chemical binding]; other site 545693003002 sugar binding site [chemical binding]; other site 545693003003 divalent metal binding site [ion binding]; other site 545693003004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693003005 dimer interface [polypeptide binding]; other site 545693003006 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 545693003007 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 545693003008 methionine cluster; other site 545693003009 active site 545693003010 phosphorylation site [posttranslational modification] 545693003011 metal binding site [ion binding]; metal-binding site 545693003012 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 545693003013 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 545693003014 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 545693003015 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 545693003016 putative active site [active] 545693003017 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693003018 HTH domain; Region: HTH_11; pfam08279 545693003019 PRD domain; Region: PRD; pfam00874 545693003020 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693003021 active site 545693003022 P-loop; other site 545693003023 phosphorylation site [posttranslational modification] 545693003024 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693003025 active site 545693003026 phosphorylation site [posttranslational modification] 545693003027 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 545693003028 active site 545693003029 P-loop; other site 545693003030 phosphorylation site [posttranslational modification] 545693003031 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 545693003032 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 545693003033 active site 545693003034 catalytic triad [active] 545693003035 dimer interface [polypeptide binding]; other site 545693003036 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 545693003037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693003038 active site 545693003039 dimer interface [polypeptide binding]; other site 545693003040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693003041 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693003042 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693003043 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693003044 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693003045 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693003046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693003047 S-adenosylmethionine binding site [chemical binding]; other site 545693003048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693003049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693003050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693003051 dimerization interface [polypeptide binding]; other site 545693003052 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 545693003053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693003054 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 545693003055 active site 545693003056 catalytic tetrad [active] 545693003057 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 545693003058 Amidase; Region: Amidase; cl11426 545693003059 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 545693003060 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 545693003061 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 545693003062 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 545693003063 NAD binding site [chemical binding]; other site 545693003064 homodimer interface [polypeptide binding]; other site 545693003065 active site 545693003066 substrate binding site [chemical binding]; other site 545693003067 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 545693003068 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693003069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003070 PAS fold; Region: PAS_4; pfam08448 545693003071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003072 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003073 putative active site [active] 545693003074 heme pocket [chemical binding]; other site 545693003075 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003077 putative active site [active] 545693003078 heme pocket [chemical binding]; other site 545693003079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693003080 metal binding site [ion binding]; metal-binding site 545693003081 active site 545693003082 I-site; other site 545693003083 Predicted transcriptional regulators [Transcription]; Region: COG1733 545693003084 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 545693003085 Sugar transport protein; Region: Sugar_transport; pfam06800 545693003086 glucose-1-dehydrogenase; Provisional; Region: PRK08936 545693003087 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 545693003088 NAD binding site [chemical binding]; other site 545693003089 homodimer interface [polypeptide binding]; other site 545693003090 active site 545693003091 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 545693003092 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 545693003093 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 545693003094 Na binding site [ion binding]; other site 545693003095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693003096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003097 ATP binding site [chemical binding]; other site 545693003098 Mg2+ binding site [ion binding]; other site 545693003099 G-X-G motif; other site 545693003100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003101 active site 545693003102 phosphorylation site [posttranslational modification] 545693003103 intermolecular recognition site; other site 545693003104 dimerization interface [polypeptide binding]; other site 545693003105 YcbB domain; Region: YcbB; pfam08664 545693003106 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693003107 YfhD-like protein; Region: YfhD; pfam14151 545693003108 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693003109 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693003110 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693003111 active site 545693003112 metal binding site [ion binding]; metal-binding site 545693003113 Stage II sporulation protein; Region: SpoIID; pfam08486 545693003114 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 545693003115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693003116 active site 545693003117 catalytic tetrad [active] 545693003118 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693003119 IDEAL domain; Region: IDEAL; cl07452 545693003120 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 545693003121 transmembrane helices; other site 545693003122 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 545693003123 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 545693003124 active site 545693003125 octamer interface [polypeptide binding]; other site 545693003126 Uncharacterized conserved protein [Function unknown]; Region: COG3375 545693003127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003128 Coenzyme A binding pocket [chemical binding]; other site 545693003129 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693003130 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693003131 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693003132 putative active site [active] 545693003133 PAS domain; Region: PAS_9; pfam13426 545693003134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003135 putative active site [active] 545693003136 heme pocket [chemical binding]; other site 545693003137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693003138 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693003139 Walker A motif; other site 545693003140 ATP binding site [chemical binding]; other site 545693003141 Walker B motif; other site 545693003142 arginine finger; other site 545693003143 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693003144 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693003145 inhibitor-cofactor binding pocket; inhibition site 545693003146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003147 catalytic residue [active] 545693003148 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 545693003149 Na binding site [ion binding]; other site 545693003150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693003151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693003152 putative substrate translocation pore; other site 545693003153 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 545693003154 MMPL family; Region: MMPL; cl14618 545693003155 MMPL family; Region: MMPL; cl14618 545693003156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693003157 dimerization interface [polypeptide binding]; other site 545693003158 putative DNA binding site [nucleotide binding]; other site 545693003159 putative Zn2+ binding site [ion binding]; other site 545693003160 Predicted integral membrane protein [Function unknown]; Region: COG5658 545693003161 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 545693003162 SdpI/YhfL protein family; Region: SdpI; pfam13630 545693003163 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693003164 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693003165 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 545693003166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693003167 dimerization interface [polypeptide binding]; other site 545693003168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693003169 metal binding site [ion binding]; metal-binding site 545693003170 active site 545693003171 I-site; other site 545693003172 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003173 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 545693003174 active site 545693003175 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693003176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693003177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003178 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003179 putative active site [active] 545693003180 heme pocket [chemical binding]; other site 545693003181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003182 heme pocket [chemical binding]; other site 545693003183 putative active site [active] 545693003184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003185 PAS fold; Region: PAS_3; pfam08447 545693003186 putative active site [active] 545693003187 heme pocket [chemical binding]; other site 545693003188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693003189 metal binding site [ion binding]; metal-binding site 545693003190 active site 545693003191 I-site; other site 545693003192 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003193 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693003194 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693003195 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 545693003196 putative active site; other site 545693003197 catalytic triad [active] 545693003198 putative dimer interface [polypeptide binding]; other site 545693003199 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 545693003200 active site 545693003201 Zn binding site [ion binding]; other site 545693003202 flagellin; Provisional; Region: PRK12804 545693003203 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 545693003204 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 545693003205 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 545693003206 putative substrate binding pocket [chemical binding]; other site 545693003207 AC domain interface; other site 545693003208 catalytic triad [active] 545693003209 AB domain interface; other site 545693003210 interchain disulfide; other site 545693003211 Protein of unknown function (DUF979); Region: DUF979; pfam06166 545693003212 Protein of unknown function (DUF969); Region: DUF969; pfam06149 545693003213 Predicted membrane protein [Function unknown]; Region: COG4640 545693003214 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 545693003215 HPP family; Region: HPP; pfam04982 545693003216 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 545693003217 histidinol-phosphatase; Provisional; Region: PRK05588 545693003218 active site 545693003219 Anti-repressor SinI; Region: SinI; pfam08671 545693003220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693003221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693003222 non-specific DNA binding site [nucleotide binding]; other site 545693003223 salt bridge; other site 545693003224 sequence-specific DNA binding site [nucleotide binding]; other site 545693003225 Anti-repressor SinI; Region: SinI; pfam08671 545693003226 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 545693003227 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 545693003228 Chain length determinant protein; Region: Wzz; pfam02706 545693003229 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 545693003230 Bacterial sugar transferase; Region: Bac_transf; pfam02397 545693003231 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693003232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003233 NAD(P) binding site [chemical binding]; other site 545693003234 active site 545693003235 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 545693003236 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 545693003237 O-Antigen ligase; Region: Wzy_C; pfam04932 545693003238 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693003239 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693003240 active site 545693003241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693003243 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 545693003244 Stage II sporulation protein; Region: SpoIID; pfam08486 545693003245 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 545693003246 VanZ like family; Region: VanZ; cl01971 545693003247 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 545693003248 PHP domain; Region: PHP; pfam02811 545693003249 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693003250 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 545693003251 active site 545693003252 tetramer interface; other site 545693003253 Bacterial sugar transferase; Region: Bac_transf; pfam02397 545693003254 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 545693003255 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 545693003256 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 545693003257 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 545693003258 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 545693003259 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693003260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003261 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 545693003262 trimer interface [polypeptide binding]; other site 545693003263 active site 545693003264 CoA binding site [chemical binding]; other site 545693003265 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 545693003266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003267 putative ADP-binding pocket [chemical binding]; other site 545693003268 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 545693003269 trimer interface [polypeptide binding]; other site 545693003270 active site 545693003271 substrate binding site [chemical binding]; other site 545693003272 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 545693003273 CoA binding site [chemical binding]; other site 545693003274 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 545693003275 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 545693003276 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 545693003277 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 545693003278 putative metal binding site [ion binding]; other site 545693003279 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 545693003280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693003281 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 545693003282 active site 545693003283 Cupin domain; Region: Cupin_2; cl17218 545693003284 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 545693003285 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 545693003286 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 545693003287 Chain length determinant protein; Region: Wzz; pfam02706 545693003288 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 545693003289 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 545693003290 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 545693003291 Magnesium ion binding site [ion binding]; other site 545693003292 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693003293 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 545693003294 active site 545693003295 tetramer interface; other site 545693003296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003297 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 545693003298 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693003299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693003301 active site 545693003302 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 545693003303 putative glycosyl transferase; Provisional; Region: PRK10073 545693003304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693003305 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 545693003306 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 545693003307 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 545693003308 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 545693003309 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 545693003310 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 545693003311 Walker A/P-loop; other site 545693003312 ATP binding site [chemical binding]; other site 545693003313 Q-loop/lid; other site 545693003314 ABC transporter signature motif; other site 545693003315 Walker B; other site 545693003316 D-loop; other site 545693003317 H-loop/switch region; other site 545693003318 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693003319 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 545693003320 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 545693003321 active site 545693003322 catalytic triad [active] 545693003323 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 545693003324 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 545693003325 pyruvate oxidase; Provisional; Region: PRK08611 545693003326 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 545693003327 PYR/PP interface [polypeptide binding]; other site 545693003328 dimer interface [polypeptide binding]; other site 545693003329 tetramer interface [polypeptide binding]; other site 545693003330 TPP binding site [chemical binding]; other site 545693003331 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693003332 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 545693003333 TPP-binding site [chemical binding]; other site 545693003334 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 545693003335 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 545693003336 active site 545693003337 FMN binding site [chemical binding]; other site 545693003338 substrate binding site [chemical binding]; other site 545693003339 3Fe-4S cluster binding site [ion binding]; other site 545693003340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693003341 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 545693003342 DNA-binding site [nucleotide binding]; DNA binding site 545693003343 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 545693003344 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 545693003345 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693003346 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 545693003347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 545693003348 GntP family permease; Region: GntP_permease; pfam02447 545693003349 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693003350 ComK protein; Region: ComK; cl11560 545693003351 RNA polymerase factor sigma-70; Validated; Region: PRK06759 545693003352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693003353 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693003354 DNA binding residues [nucleotide binding] 545693003355 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 545693003356 active site 545693003357 oxyanion hole [active] 545693003358 catalytic triad [active] 545693003359 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 545693003360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693003361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003362 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 545693003363 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 545693003364 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693003365 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 545693003366 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 545693003367 [2Fe-2S] cluster binding site [ion binding]; other site 545693003368 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 545693003369 active site 545693003370 SAM binding site [chemical binding]; other site 545693003371 homodimer interface [polypeptide binding]; other site 545693003372 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 545693003373 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 545693003374 putative substrate binding site [chemical binding]; other site 545693003375 putative ATP binding site [chemical binding]; other site 545693003376 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 545693003377 Sugar transport protein; Region: Sugar_transport; pfam06800 545693003378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693003379 active site 545693003380 metal binding site [ion binding]; metal-binding site 545693003381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693003382 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 545693003383 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 545693003384 GIY-YIG motif/motif A; other site 545693003385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 545693003386 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 545693003387 Cupin; Region: Cupin_1; smart00835 545693003388 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693003389 PilZ domain; Region: PilZ; pfam07238 545693003390 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693003391 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 545693003392 oligomer interface [polypeptide binding]; other site 545693003393 metal binding site [ion binding]; metal-binding site 545693003394 metal binding site [ion binding]; metal-binding site 545693003395 putative Cl binding site [ion binding]; other site 545693003396 aspartate ring; other site 545693003397 basic sphincter; other site 545693003398 hydrophobic gate; other site 545693003399 periplasmic entrance; other site 545693003400 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 545693003401 Subtilase family; Region: Peptidase_S8; pfam00082 545693003402 active site 545693003403 catalytic triad [active] 545693003404 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 545693003405 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 545693003406 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693003407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003408 Coenzyme A binding pocket [chemical binding]; other site 545693003409 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693003410 putative active site [active] 545693003411 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693003412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693003413 DNA-binding site [nucleotide binding]; DNA binding site 545693003414 UTRA domain; Region: UTRA; pfam07702 545693003415 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 545693003416 active site 545693003417 trimer interface [polypeptide binding]; other site 545693003418 allosteric site; other site 545693003419 active site lid [active] 545693003420 hexamer (dimer of trimers) interface [polypeptide binding]; other site 545693003421 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 545693003422 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 545693003423 active site 545693003424 dimer interface [polypeptide binding]; other site 545693003425 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 545693003426 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693003427 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693003428 active site turn [active] 545693003429 phosphorylation site [posttranslational modification] 545693003430 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 545693003431 HPr interaction site; other site 545693003432 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693003433 active site 545693003434 phosphorylation site [posttranslational modification] 545693003435 Protein of unknown function (DUF554); Region: DUF554; pfam04474 545693003436 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 545693003437 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 545693003438 dimer interface [polypeptide binding]; other site 545693003439 PYR/PP interface [polypeptide binding]; other site 545693003440 TPP binding site [chemical binding]; other site 545693003441 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693003442 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 545693003443 TPP-binding site [chemical binding]; other site 545693003444 dimer interface [polypeptide binding]; other site 545693003445 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693003446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693003447 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 545693003448 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 545693003449 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 545693003450 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 545693003451 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693003452 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693003453 Walker A/P-loop; other site 545693003454 ATP binding site [chemical binding]; other site 545693003455 Q-loop/lid; other site 545693003456 ABC transporter signature motif; other site 545693003457 Walker B; other site 545693003458 D-loop; other site 545693003459 H-loop/switch region; other site 545693003460 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693003461 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693003462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693003463 Transporter associated domain; Region: CorC_HlyC; smart01091 545693003464 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693003465 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693003466 DNA binding residues [nucleotide binding] 545693003467 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 545693003468 putative metal binding site [ion binding]; other site 545693003469 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 545693003470 putative active site pocket [active] 545693003471 dimerization interface [polypeptide binding]; other site 545693003472 putative catalytic residue [active] 545693003473 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 545693003474 putative active site pocket [active] 545693003475 dimerization interface [polypeptide binding]; other site 545693003476 putative catalytic residue [active] 545693003477 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 545693003478 active site 545693003479 catalytic residues [active] 545693003480 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 545693003481 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693003482 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693003483 Catalytic site [active] 545693003484 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 545693003485 YmaF family; Region: YmaF; pfam12788 545693003486 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693003487 Protein of unknown function DUF45; Region: DUF45; cl00636 545693003488 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693003489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003490 Coenzyme A binding pocket [chemical binding]; other site 545693003491 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693003492 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 545693003493 metal binding site [ion binding]; metal-binding site 545693003494 dimer interface [polypeptide binding]; other site 545693003495 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 545693003496 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 545693003497 putative metal binding site [ion binding]; other site 545693003498 putative dimer interface [polypeptide binding]; other site 545693003499 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 545693003500 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693003501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003502 Coenzyme A binding pocket [chemical binding]; other site 545693003503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693003504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693003505 putative substrate translocation pore; other site 545693003506 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693003507 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 545693003508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003509 ATP binding site [chemical binding]; other site 545693003510 Mg2+ binding site [ion binding]; other site 545693003511 G-X-G motif; other site 545693003512 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693003513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003514 active site 545693003515 phosphorylation site [posttranslational modification] 545693003516 intermolecular recognition site; other site 545693003517 dimerization interface [polypeptide binding]; other site 545693003518 LytTr DNA-binding domain; Region: LytTR; smart00850 545693003519 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693003520 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 545693003521 Walker A/P-loop; other site 545693003522 ATP binding site [chemical binding]; other site 545693003523 Q-loop/lid; other site 545693003524 ABC transporter signature motif; other site 545693003525 Walker B; other site 545693003526 D-loop; other site 545693003527 H-loop/switch region; other site 545693003528 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693003529 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 545693003530 Phosphotransferase enzyme family; Region: APH; pfam01636 545693003531 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 545693003532 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693003533 DNA binding residues [nucleotide binding] 545693003534 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693003535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693003536 methionine sulfoxide reductase A; Provisional; Region: PRK14054 545693003537 methionine sulfoxide reductase B; Provisional; Region: PRK00222 545693003538 Spore germination protein; Region: Spore_permease; cl17796 545693003539 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 545693003540 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693003541 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 545693003542 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 545693003543 dimer interface [polypeptide binding]; other site 545693003544 active site 545693003545 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 545693003546 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693003547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003548 active site 545693003549 phosphorylation site [posttranslational modification] 545693003550 intermolecular recognition site; other site 545693003551 dimerization interface [polypeptide binding]; other site 545693003552 LytTr DNA-binding domain; Region: LytTR; smart00850 545693003553 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 545693003554 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 545693003555 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 545693003556 Binuclear center (active site) [active] 545693003557 K-pathway; other site 545693003558 Putative proton exit pathway; other site 545693003559 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 545693003560 PAS domain S-box; Region: sensory_box; TIGR00229 545693003561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003562 putative active site [active] 545693003563 heme pocket [chemical binding]; other site 545693003564 PAS domain; Region: PAS_9; pfam13426 545693003565 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693003566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003567 putative active site [active] 545693003568 heme pocket [chemical binding]; other site 545693003569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693003570 dimer interface [polypeptide binding]; other site 545693003571 phosphorylation site [posttranslational modification] 545693003572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003573 ATP binding site [chemical binding]; other site 545693003574 Mg2+ binding site [ion binding]; other site 545693003575 G-X-G motif; other site 545693003576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003577 active site 545693003578 phosphorylation site [posttranslational modification] 545693003579 intermolecular recognition site; other site 545693003580 dimerization interface [polypeptide binding]; other site 545693003581 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 545693003582 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 545693003583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693003584 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693003585 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 545693003586 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 545693003587 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 545693003588 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693003589 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693003590 NAD(P) binding site [chemical binding]; other site 545693003591 homotetramer interface [polypeptide binding]; other site 545693003592 homodimer interface [polypeptide binding]; other site 545693003593 active site 545693003594 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 545693003595 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 545693003596 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 545693003597 Cation transport protein; Region: TrkH; cl17365 545693003598 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 545693003599 Cation transport protein; Region: TrkH; pfam02386 545693003600 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 545693003601 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 545693003602 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 545693003603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693003604 FeS/SAM binding site; other site 545693003605 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 545693003606 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693003607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693003608 DNA-binding site [nucleotide binding]; DNA binding site 545693003609 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 545693003610 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 545693003611 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 545693003612 active site 545693003613 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 545693003614 homodimer interface [polypeptide binding]; other site 545693003615 NAD binding pocket [chemical binding]; other site 545693003616 ATP binding pocket [chemical binding]; other site 545693003617 Mg binding site [ion binding]; other site 545693003618 active-site loop [active] 545693003619 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693003620 Cysteine-rich domain; Region: CCG; pfam02754 545693003621 Cysteine-rich domain; Region: CCG; pfam02754 545693003622 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 545693003623 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 545693003624 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 545693003625 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 545693003626 Uncharacterized conserved protein [Function unknown]; Region: COG1556 545693003627 PAS domain; Region: PAS; smart00091 545693003628 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003630 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003631 putative active site [active] 545693003632 heme pocket [chemical binding]; other site 545693003633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003634 putative active site [active] 545693003635 heme pocket [chemical binding]; other site 545693003636 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693003637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003638 putative active site [active] 545693003639 heme pocket [chemical binding]; other site 545693003640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693003641 dimer interface [polypeptide binding]; other site 545693003642 phosphorylation site [posttranslational modification] 545693003643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003644 ATP binding site [chemical binding]; other site 545693003645 Mg2+ binding site [ion binding]; other site 545693003646 G-X-G motif; other site 545693003647 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 545693003648 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 545693003649 DNA binding site [nucleotide binding] 545693003650 active site 545693003651 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 545693003652 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 545693003653 Phosphotransferase enzyme family; Region: APH; pfam01636 545693003654 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 545693003655 putative active site [active] 545693003656 catalytic triad [active] 545693003657 putative dimer interface [polypeptide binding]; other site 545693003658 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 545693003659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693003660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003661 homodimer interface [polypeptide binding]; other site 545693003662 catalytic residue [active] 545693003663 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 545693003664 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 545693003665 dimer interface [polypeptide binding]; other site 545693003666 active site 545693003667 catalytic residue [active] 545693003668 metal binding site [ion binding]; metal-binding site 545693003669 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 545693003670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003671 active site 545693003672 motif I; other site 545693003673 motif II; other site 545693003674 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 545693003675 intersubunit interface [polypeptide binding]; other site 545693003676 active site 545693003677 Zn2+ binding site [ion binding]; other site 545693003678 Cupin domain; Region: Cupin_2; cl17218 545693003679 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 545693003680 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 545693003681 putative ligand binding site [chemical binding]; other site 545693003682 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 545693003683 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 545693003684 Walker A/P-loop; other site 545693003685 ATP binding site [chemical binding]; other site 545693003686 Q-loop/lid; other site 545693003687 ABC transporter signature motif; other site 545693003688 Walker B; other site 545693003689 D-loop; other site 545693003690 H-loop/switch region; other site 545693003691 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 545693003692 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 545693003693 TM-ABC transporter signature motif; other site 545693003694 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 545693003695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693003696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003697 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 545693003698 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693003699 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 545693003700 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 545693003701 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 545693003702 nucleotide binding site/active site [active] 545693003703 HIT family signature motif; other site 545693003704 catalytic residue [active] 545693003705 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693003706 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693003707 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 545693003708 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 545693003709 active site 545693003710 Zn binding site [ion binding]; other site 545693003711 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 545693003712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003713 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693003714 putative active site [active] 545693003715 heme pocket [chemical binding]; other site 545693003716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693003717 dimer interface [polypeptide binding]; other site 545693003718 phosphorylation site [posttranslational modification] 545693003719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003720 ATP binding site [chemical binding]; other site 545693003721 Mg2+ binding site [ion binding]; other site 545693003722 G-X-G motif; other site 545693003723 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 545693003724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693003725 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 545693003726 Walker A motif; other site 545693003727 ATP binding site [chemical binding]; other site 545693003728 Walker B motif; other site 545693003729 arginine finger; other site 545693003730 UvrB/uvrC motif; Region: UVR; pfam02151 545693003731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693003732 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 545693003733 Walker A motif; other site 545693003734 ATP binding site [chemical binding]; other site 545693003735 Walker B motif; other site 545693003736 arginine finger; other site 545693003737 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 545693003738 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 545693003739 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693003740 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 545693003741 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 545693003742 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693003743 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 545693003744 classical (c) SDRs; Region: SDR_c; cd05233 545693003745 NAD(P) binding site [chemical binding]; other site 545693003746 active site 545693003747 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693003748 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 545693003749 Spore germination protein; Region: Spore_permease; cl17796 545693003750 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 545693003751 Ligand Binding Site [chemical binding]; other site 545693003752 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 545693003753 active site 545693003754 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 545693003755 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 545693003756 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 545693003757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003758 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 545693003759 NAD(P) binding site [chemical binding]; other site 545693003760 active site 545693003761 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 545693003762 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 545693003763 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 545693003764 active site 545693003765 nucleophile elbow; other site 545693003766 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693003767 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693003768 potential frameshift: common BLAST hit: gi|52787060|ref|YP_092889.1| YueI 545693003769 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 545693003770 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 545693003771 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693003772 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693003773 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 545693003774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003775 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693003776 active site 545693003777 motif I; other site 545693003778 motif II; other site 545693003779 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 545693003780 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693003781 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 545693003782 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 545693003783 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 545693003784 substrate binding pocket [chemical binding]; other site 545693003785 dimer interface [polypeptide binding]; other site 545693003786 inhibitor binding site; inhibition site 545693003787 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 545693003788 B12 binding site [chemical binding]; other site 545693003789 cobalt ligand [ion binding]; other site 545693003790 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 545693003791 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 545693003792 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 545693003793 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 545693003794 FAD binding site [chemical binding]; other site 545693003795 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 545693003796 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 545693003797 Lumazine binding domain; Region: Lum_binding; pfam00677 545693003798 Lumazine binding domain; Region: Lum_binding; pfam00677 545693003799 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 545693003800 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 545693003801 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 545693003802 dimerization interface [polypeptide binding]; other site 545693003803 active site 545693003804 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 545693003805 homopentamer interface [polypeptide binding]; other site 545693003806 active site 545693003807 transcriptional antiterminator BglG; Provisional; Region: PRK09772 545693003808 CAT RNA binding domain; Region: CAT_RBD; smart01061 545693003809 PRD domain; Region: PRD; pfam00874 545693003810 PRD domain; Region: PRD; pfam00874 545693003811 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693003812 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 545693003813 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693003814 active site turn [active] 545693003815 phosphorylation site [posttranslational modification] 545693003816 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 545693003817 HPr interaction site; other site 545693003818 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693003819 active site 545693003820 phosphorylation site [posttranslational modification] 545693003821 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 545693003822 dimerization domain swap beta strand [polypeptide binding]; other site 545693003823 regulatory protein interface [polypeptide binding]; other site 545693003824 active site 545693003825 regulatory phosphorylation site [posttranslational modification]; other site 545693003826 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 545693003827 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 545693003828 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 545693003829 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 545693003830 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 545693003831 LrgA family; Region: LrgA; cl00608 545693003832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693003833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693003834 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 545693003835 putative dimerization interface [polypeptide binding]; other site 545693003836 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693003837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003838 Coenzyme A binding pocket [chemical binding]; other site 545693003839 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693003840 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 545693003841 putative NAD(P) binding site [chemical binding]; other site 545693003842 putative active site [active] 545693003843 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 545693003844 dimer interface [polypeptide binding]; other site 545693003845 FMN binding site [chemical binding]; other site 545693003846 aminotransferase A; Validated; Region: PRK07683 545693003847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693003848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003849 homodimer interface [polypeptide binding]; other site 545693003850 catalytic residue [active] 545693003851 IDEAL domain; Region: IDEAL; pfam08858 545693003852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693003853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693003854 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 545693003855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693003856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003857 active site 545693003858 phosphorylation site [posttranslational modification] 545693003859 intermolecular recognition site; other site 545693003860 dimerization interface [polypeptide binding]; other site 545693003861 YkyB-like protein; Region: YkyB; pfam14177 545693003862 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693003863 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693003864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693003865 exopolyphosphatase; Region: exo_poly_only; TIGR03706 545693003866 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 545693003867 polyphosphate kinase; Provisional; Region: PRK05443 545693003868 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 545693003869 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 545693003870 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 545693003871 putative domain interface [polypeptide binding]; other site 545693003872 putative active site [active] 545693003873 catalytic site [active] 545693003874 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 545693003875 putative domain interface [polypeptide binding]; other site 545693003876 putative active site [active] 545693003877 catalytic site [active] 545693003878 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 545693003879 putative active site [active] 545693003880 putative metal binding site [ion binding]; other site 545693003881 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 545693003882 short chain dehydrogenase; Provisional; Region: PRK07677 545693003883 NAD(P) binding site [chemical binding]; other site 545693003884 substrate binding site [chemical binding]; other site 545693003885 homotetramer interface [polypeptide binding]; other site 545693003886 active site 545693003887 homodimer interface [polypeptide binding]; other site 545693003888 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003889 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 545693003890 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 545693003891 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 545693003892 catalytic residues [active] 545693003893 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 545693003894 FOG: CBS domain [General function prediction only]; Region: COG0517 545693003895 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 545693003896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693003897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693003898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693003899 dimerization interface [polypeptide binding]; other site 545693003900 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 545693003901 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 545693003902 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 545693003903 trimer interface [polypeptide binding]; other site 545693003904 active site 545693003905 substrate binding site [chemical binding]; other site 545693003906 CoA binding site [chemical binding]; other site 545693003907 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693003908 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 545693003909 metal binding site [ion binding]; metal-binding site 545693003910 putative dimer interface [polypeptide binding]; other site 545693003911 hypothetical protein; Provisional; Region: PRK03094 545693003912 mechanosensitive channel MscS; Provisional; Region: PRK10334 545693003913 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693003914 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 545693003915 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 545693003916 dimer interface [polypeptide binding]; other site 545693003917 decamer (pentamer of dimers) interface [polypeptide binding]; other site 545693003918 catalytic triad [active] 545693003919 peroxidatic and resolving cysteines [active] 545693003920 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693003921 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 545693003922 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693003923 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 545693003924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693003925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693003926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693003927 Walker A/P-loop; other site 545693003928 ATP binding site [chemical binding]; other site 545693003929 Q-loop/lid; other site 545693003930 ABC transporter signature motif; other site 545693003931 Walker B; other site 545693003932 D-loop; other site 545693003933 H-loop/switch region; other site 545693003934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693003935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693003936 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 545693003937 Walker A/P-loop; other site 545693003938 ATP binding site [chemical binding]; other site 545693003939 Q-loop/lid; other site 545693003940 ABC transporter signature motif; other site 545693003941 Walker B; other site 545693003942 D-loop; other site 545693003943 H-loop/switch region; other site 545693003944 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 545693003945 TrkA-N domain; Region: TrkA_N; pfam02254 545693003946 TrkA-C domain; Region: TrkA_C; pfam02080 545693003947 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 545693003948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693003949 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 545693003950 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 545693003951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003952 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693003953 active site 545693003954 motif I; other site 545693003955 motif II; other site 545693003956 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693003957 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 545693003958 active site 545693003959 catalytic residues [active] 545693003960 metal binding site [ion binding]; metal-binding site 545693003961 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 545693003962 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 545693003963 TPP-binding site [chemical binding]; other site 545693003964 tetramer interface [polypeptide binding]; other site 545693003965 heterodimer interface [polypeptide binding]; other site 545693003966 phosphorylation loop region [posttranslational modification] 545693003967 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 545693003968 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 545693003969 alpha subunit interface [polypeptide binding]; other site 545693003970 TPP binding site [chemical binding]; other site 545693003971 heterodimer interface [polypeptide binding]; other site 545693003972 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693003973 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 545693003974 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693003975 E3 interaction surface; other site 545693003976 lipoyl attachment site [posttranslational modification]; other site 545693003977 e3 binding domain; Region: E3_binding; pfam02817 545693003978 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 545693003979 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 545693003980 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693003981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003982 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 545693003983 glycine/betaine transporter, point mutation 545693003984 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 545693003985 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 545693003986 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 545693003987 homodimer interface [polypeptide binding]; other site 545693003988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003989 catalytic residue [active] 545693003990 EAP30/Vps36 family; Region: EAP30; pfam04157 545693003991 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 545693003992 hypothetical protein; Provisional; Region: PRK04387 545693003993 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 545693003994 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 545693003995 active site 545693003996 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 545693003997 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 545693003998 G1 box; other site 545693003999 putative GEF interaction site [polypeptide binding]; other site 545693004000 GTP/Mg2+ binding site [chemical binding]; other site 545693004001 Switch I region; other site 545693004002 G2 box; other site 545693004003 G3 box; other site 545693004004 Switch II region; other site 545693004005 G4 box; other site 545693004006 G5 box; other site 545693004007 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 545693004008 Elongation Factor G, domain II; Region: EFG_II; pfam14492 545693004009 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 545693004010 YlaH-like protein; Region: YlaH; pfam14036 545693004011 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 545693004012 hypothetical protein; Provisional; Region: PRK06733 545693004013 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693004014 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693004015 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 545693004016 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 545693004017 putative active site [active] 545693004018 PhoH-like protein; Region: PhoH; pfam02562 545693004019 hypothetical protein; Provisional; Region: PRK13666 545693004020 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 545693004021 pyruvate carboxylase; Reviewed; Region: PRK12999 545693004022 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693004023 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 545693004024 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 545693004025 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 545693004026 active site 545693004027 catalytic residues [active] 545693004028 metal binding site [ion binding]; metal-binding site 545693004029 homodimer binding site [polypeptide binding]; other site 545693004030 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 545693004031 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693004032 carboxyltransferase (CT) interaction site; other site 545693004033 biotinylation site [posttranslational modification]; other site 545693004034 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 545693004035 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 545693004036 putative active site [active] 545693004037 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 545693004038 Cupredoxin superfamily; Region: Cupredoxin; cl19115 545693004039 Cytochrome c; Region: Cytochrom_C; pfam00034 545693004040 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 545693004041 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 545693004042 D-pathway; other site 545693004043 Putative ubiquinol binding site [chemical binding]; other site 545693004044 Low-spin heme (heme b) binding site [chemical binding]; other site 545693004045 Putative water exit pathway; other site 545693004046 Binuclear center (heme o3/CuB) [ion binding]; other site 545693004047 K-pathway; other site 545693004048 Putative proton exit pathway; other site 545693004049 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 545693004050 Subunit I/III interface [polypeptide binding]; other site 545693004051 Subunit III/IV interface [polypeptide binding]; other site 545693004052 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 545693004053 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 545693004054 YugN-like family; Region: YugN; pfam08868 545693004055 FOG: CBS domain [General function prediction only]; Region: COG0517 545693004056 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 545693004057 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 545693004058 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 545693004059 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 545693004060 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 545693004061 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 545693004062 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693004063 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693004064 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693004065 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693004066 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 545693004067 homodimer interface [polypeptide binding]; other site 545693004068 metal binding site [ion binding]; metal-binding site 545693004069 dihydrodipicolinate reductase; Provisional; Region: PRK00048 545693004070 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 545693004071 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 545693004072 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 545693004073 active site 545693004074 dimer interfaces [polypeptide binding]; other site 545693004075 catalytic residues [active] 545693004076 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 545693004077 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 545693004078 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 545693004079 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 545693004080 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 545693004081 active site 545693004082 NTP binding site [chemical binding]; other site 545693004083 metal binding triad [ion binding]; metal-binding site 545693004084 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 545693004085 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 545693004086 Biotin operon repressor [Transcription]; Region: BirA; COG1654 545693004087 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 545693004088 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 545693004089 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 545693004090 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 545693004091 oligomerization interface [polypeptide binding]; other site 545693004092 active site 545693004093 metal binding site [ion binding]; metal-binding site 545693004094 Pantoate-beta-alanine ligase; Region: PanC; cd00560 545693004095 active site 545693004096 ATP-binding site [chemical binding]; other site 545693004097 pantoate-binding site; other site 545693004098 HXXH motif; other site 545693004099 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 545693004100 tetramerization interface [polypeptide binding]; other site 545693004101 active site 545693004102 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 545693004103 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 545693004104 active site 545693004105 catalytic site [active] 545693004106 substrate binding site [chemical binding]; other site 545693004107 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 545693004108 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 545693004109 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 545693004110 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 545693004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 545693004112 aspartate aminotransferase; Provisional; Region: PRK05764 545693004113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693004114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004115 homodimer interface [polypeptide binding]; other site 545693004116 catalytic residue [active] 545693004117 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 545693004118 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 545693004119 putative dimer interface [polypeptide binding]; other site 545693004120 putative anticodon binding site; other site 545693004121 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 545693004122 homodimer interface [polypeptide binding]; other site 545693004123 motif 1; other site 545693004124 motif 2; other site 545693004125 active site 545693004126 motif 3; other site 545693004127 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 545693004128 MarR family; Region: MarR_2; pfam12802 545693004129 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 545693004130 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 545693004131 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 545693004132 minor groove reading motif; other site 545693004133 helix-hairpin-helix signature motif; other site 545693004134 substrate binding pocket [chemical binding]; other site 545693004135 active site 545693004136 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 545693004137 Transglycosylase; Region: Transgly; pfam00912 545693004138 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693004139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693004140 Nucleosome assembly protein (NAP); Region: NAP; cl08298 545693004141 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 545693004142 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 545693004143 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 545693004144 YppF-like protein; Region: YppF; pfam14178 545693004145 YppG-like protein; Region: YppG; pfam14179 545693004146 CotH protein; Region: CotH; cl19892 545693004147 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693004148 homodimer interface [polypeptide binding]; other site 545693004149 substrate-cofactor binding pocket; other site 545693004150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004151 catalytic residue [active] 545693004152 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693004153 homodimer interface [polypeptide binding]; other site 545693004154 substrate-cofactor binding pocket; other site 545693004155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004156 catalytic residue [active] 545693004157 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 545693004158 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 545693004159 Na binding site [ion binding]; other site 545693004160 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693004161 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693004162 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693004163 DNA-binding site [nucleotide binding]; DNA binding site 545693004164 RNA-binding motif; other site 545693004165 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693004166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693004167 metal binding site [ion binding]; metal-binding site 545693004168 active site 545693004169 I-site; other site 545693004170 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 545693004171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693004172 ATP binding site [chemical binding]; other site 545693004173 putative Mg++ binding site [ion binding]; other site 545693004174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693004175 nucleotide binding region [chemical binding]; other site 545693004176 ATP-binding site [chemical binding]; other site 545693004177 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 545693004178 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 545693004179 RNase_H superfamily; Region: RNase_H_2; pfam13482 545693004180 active site 545693004181 substrate binding site [chemical binding]; other site 545693004182 TPR repeat; Region: TPR_11; pfam13414 545693004183 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 545693004184 hypothetical protein; Provisional; Region: PRK13660 545693004185 cell division protein GpsB; Provisional; Region: PRK14127 545693004186 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 545693004187 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 545693004188 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 545693004189 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 545693004190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 545693004191 Histidine kinase; Region: HisKA_3; pfam07730 545693004192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693004193 ATP binding site [chemical binding]; other site 545693004194 Mg2+ binding site [ion binding]; other site 545693004195 G-X-G motif; other site 545693004196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693004197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004198 active site 545693004199 phosphorylation site [posttranslational modification] 545693004200 intermolecular recognition site; other site 545693004201 dimerization interface [polypeptide binding]; other site 545693004202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693004203 DNA binding residues [nucleotide binding] 545693004204 dimerization interface [polypeptide binding]; other site 545693004205 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 545693004206 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 545693004207 Ca binding site [ion binding]; other site 545693004208 active site 545693004209 catalytic site [active] 545693004210 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 545693004211 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 545693004212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 545693004213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693004214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004215 dimer interface [polypeptide binding]; other site 545693004216 conserved gate region; other site 545693004217 putative PBP binding loops; other site 545693004218 ABC-ATPase subunit interface; other site 545693004219 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693004220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004221 putative PBP binding loops; other site 545693004222 dimer interface [polypeptide binding]; other site 545693004223 ABC-ATPase subunit interface; other site 545693004224 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693004225 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 545693004226 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693004227 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 545693004228 Walker A/P-loop; other site 545693004229 ATP binding site [chemical binding]; other site 545693004230 Q-loop/lid; other site 545693004231 ABC transporter signature motif; other site 545693004232 Walker B; other site 545693004233 D-loop; other site 545693004234 H-loop/switch region; other site 545693004235 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 545693004236 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 545693004237 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 545693004238 active site 545693004239 Zn binding site [ion binding]; other site 545693004240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693004241 active site 545693004242 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693004243 xanthine permease; Region: pbuX; TIGR03173 545693004244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693004246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693004247 dimerization interface [polypeptide binding]; other site 545693004248 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 545693004249 tetramerization interface [polypeptide binding]; other site 545693004250 NAD(P) binding site [chemical binding]; other site 545693004251 catalytic residues [active] 545693004252 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693004253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004254 Coenzyme A binding pocket [chemical binding]; other site 545693004255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693004256 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 545693004257 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 545693004258 malonyl-CoA binding site [chemical binding]; other site 545693004259 dimer interface [polypeptide binding]; other site 545693004260 active site 545693004261 product binding site; other site 545693004262 Phospholipid methyltransferase; Region: PEMT; cl17370 545693004263 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 545693004264 G1 box; other site 545693004265 GTP/Mg2+ binding site [chemical binding]; other site 545693004266 G2 box; other site 545693004267 Switch I region; other site 545693004268 G3 box; other site 545693004269 Switch II region; other site 545693004270 G4 box; other site 545693004271 G5 box; other site 545693004272 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 545693004273 G1 box; other site 545693004274 GTP/Mg2+ binding site [chemical binding]; other site 545693004275 G2 box; other site 545693004276 Switch I region; other site 545693004277 G3 box; other site 545693004278 Switch II region; other site 545693004279 G4 box; other site 545693004280 G5 box; other site 545693004281 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 545693004282 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 545693004283 Divergent PAP2 family; Region: DUF212; pfam02681 545693004284 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 545693004285 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693004286 active site 545693004287 hypothetical protein; Validated; Region: PRK07708 545693004288 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 545693004289 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693004290 active site 545693004291 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 545693004292 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 545693004293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693004294 DNA-binding site [nucleotide binding]; DNA binding site 545693004295 RNA-binding motif; other site 545693004296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004298 putative substrate translocation pore; other site 545693004299 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 545693004300 putative active site [active] 545693004301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004302 TPR motif; other site 545693004303 binding surface 545693004304 TPR repeat; Region: TPR_11; pfam13414 545693004305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004306 binding surface 545693004307 TPR motif; other site 545693004308 TPR repeat; Region: TPR_11; pfam13414 545693004309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004310 binding surface 545693004311 TPR motif; other site 545693004312 Tetratricopeptide repeat; Region: TPR_16; pfam13432 545693004313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693004314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004315 binding surface 545693004316 TPR motif; other site 545693004317 Tetratricopeptide repeat; Region: TPR_16; pfam13432 545693004318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004319 TPR motif; other site 545693004320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004321 TPR motif; other site 545693004322 binding surface 545693004323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004324 binding surface 545693004325 TPR motif; other site 545693004326 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693004327 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 545693004328 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 545693004329 SxDxEG motif; other site 545693004330 active site 545693004331 metal binding site [ion binding]; metal-binding site 545693004332 homopentamer interface [polypeptide binding]; other site 545693004333 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693004334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004335 dimer interface [polypeptide binding]; other site 545693004336 conserved gate region; other site 545693004337 putative PBP binding loops; other site 545693004338 ABC-ATPase subunit interface; other site 545693004339 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693004340 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693004341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004342 dimer interface [polypeptide binding]; other site 545693004343 conserved gate region; other site 545693004344 putative PBP binding loops; other site 545693004345 ABC-ATPase subunit interface; other site 545693004346 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693004347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693004348 Walker A/P-loop; other site 545693004349 ATP binding site [chemical binding]; other site 545693004350 Q-loop/lid; other site 545693004351 ABC transporter signature motif; other site 545693004352 Walker B; other site 545693004353 D-loop; other site 545693004354 H-loop/switch region; other site 545693004355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693004356 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 545693004357 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 545693004358 peptide binding site [polypeptide binding]; other site 545693004359 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 545693004360 dimer interface [polypeptide binding]; other site 545693004361 catalytic triad [active] 545693004362 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693004363 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693004364 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 545693004365 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693004366 Walker A/P-loop; other site 545693004367 ATP binding site [chemical binding]; other site 545693004368 Q-loop/lid; other site 545693004369 ABC transporter signature motif; other site 545693004370 Walker B; other site 545693004371 D-loop; other site 545693004372 H-loop/switch region; other site 545693004373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693004374 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 545693004375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693004376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693004377 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 545693004378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004379 PAS domain S-box; Region: sensory_box; TIGR00229 545693004380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693004381 putative active site [active] 545693004382 heme pocket [chemical binding]; other site 545693004383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693004384 metal binding site [ion binding]; metal-binding site 545693004385 active site 545693004386 I-site; other site 545693004387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693004388 Uncharacterized conserved protein [Function unknown]; Region: COG0398 545693004389 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 545693004390 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693004391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004392 active site 545693004393 phosphorylation site [posttranslational modification] 545693004394 intermolecular recognition site; other site 545693004395 dimerization interface [polypeptide binding]; other site 545693004396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693004397 DNA binding residues [nucleotide binding] 545693004398 dimerization interface [polypeptide binding]; other site 545693004399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 545693004400 Histidine kinase; Region: HisKA_3; pfam07730 545693004401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693004402 ATP binding site [chemical binding]; other site 545693004403 Mg2+ binding site [ion binding]; other site 545693004404 G-X-G motif; other site 545693004405 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 545693004406 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 545693004407 putative di-iron ligands [ion binding]; other site 545693004408 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 545693004409 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 545693004410 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693004411 putative active site [active] 545693004412 catalytic site [active] 545693004413 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693004414 putative active site [active] 545693004415 catalytic site [active] 545693004416 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 545693004417 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 545693004418 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693004419 Bacterial SH3 domain homologues; Region: SH3b; smart00287 545693004420 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693004421 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 545693004422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693004423 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 545693004424 active site 545693004425 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 545693004426 glycosyltransferase, MGT family; Region: MGT; TIGR01426 545693004427 active site 545693004428 TDP-binding site; other site 545693004429 acceptor substrate-binding pocket; other site 545693004430 homodimer interface [polypeptide binding]; other site 545693004431 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 545693004432 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693004433 active site 545693004434 tetramer interface; other site 545693004435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004436 sugar efflux transporter; Region: 2A0120; TIGR00899 545693004437 putative substrate translocation pore; other site 545693004438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004440 putative substrate translocation pore; other site 545693004441 Protein of unknown function, DUF393; Region: DUF393; pfam04134 545693004442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004443 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 545693004444 NAD(P) binding site [chemical binding]; other site 545693004445 active site 545693004446 dihydroorotase; Provisional; Region: PRK09237 545693004447 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693004448 active site 545693004449 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 545693004450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693004451 catalytic residue [active] 545693004452 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 545693004453 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693004454 substrate binding site [chemical binding]; other site 545693004455 ATP binding site [chemical binding]; other site 545693004456 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693004457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693004458 DNA-binding site [nucleotide binding]; DNA binding site 545693004459 UTRA domain; Region: UTRA; pfam07702 545693004460 GntP family permease; Region: GntP_permease; pfam02447 545693004461 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693004462 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 545693004463 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693004464 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 545693004465 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693004466 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693004467 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 545693004468 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 545693004469 dimer interface [polypeptide binding]; other site 545693004470 active site 545693004471 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 545693004472 catalytic residues [active] 545693004473 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 545693004474 Subtilase family; Region: Peptidase_S8; pfam00082 545693004475 active site 545693004476 catalytic residues [active] 545693004477 Endonuclease I; Region: Endonuclease_1; cl01003 545693004478 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693004480 dimerization interface [polypeptide binding]; other site 545693004481 putative Zn2+ binding site [ion binding]; other site 545693004482 putative DNA binding site [nucleotide binding]; other site 545693004483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693004484 E3 interaction surface; other site 545693004485 lipoyl attachment site [posttranslational modification]; other site 545693004486 HlyD family secretion protein; Region: HlyD_3; pfam13437 545693004487 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693004488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004489 putative substrate translocation pore; other site 545693004490 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693004491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693004493 non-specific DNA binding site [nucleotide binding]; other site 545693004494 salt bridge; other site 545693004495 sequence-specific DNA binding site [nucleotide binding]; other site 545693004496 tumor necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 545693004497 YfhD-like protein; Region: YfhD; pfam14151 545693004498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693004499 ABC-ATPase subunit interface; other site 545693004500 dimer interface [polypeptide binding]; other site 545693004501 putative PBP binding regions; other site 545693004502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693004503 ABC-ATPase subunit interface; other site 545693004504 dimer interface [polypeptide binding]; other site 545693004505 putative PBP binding regions; other site 545693004506 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 545693004507 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 545693004508 putative ligand binding residues [chemical binding]; other site 545693004509 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693004510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693004511 Walker A/P-loop; other site 545693004512 ATP binding site [chemical binding]; other site 545693004513 Q-loop/lid; other site 545693004514 ABC transporter signature motif; other site 545693004515 Walker B; other site 545693004516 D-loop; other site 545693004517 H-loop/switch region; other site 545693004518 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693004519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693004520 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693004521 homodimer interface [polypeptide binding]; other site 545693004522 substrate-cofactor binding pocket; other site 545693004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004524 catalytic residue [active] 545693004525 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 545693004526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004527 putative substrate translocation pore; other site 545693004528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693004529 active site 545693004530 catalytic tetrad [active] 545693004531 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 545693004532 CoenzymeA binding site [chemical binding]; other site 545693004533 subunit interaction site [polypeptide binding]; other site 545693004534 PHB binding site; other site 545693004535 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693004536 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693004537 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693004538 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 545693004539 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 545693004540 active site 545693004541 dimer interface [polypeptide binding]; other site 545693004542 magnesium binding site [ion binding]; other site 545693004543 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 545693004544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693004545 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 545693004546 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 545693004547 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 545693004548 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 545693004549 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 545693004550 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 545693004551 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 545693004552 [2Fe-2S] cluster binding site [ion binding]; other site 545693004553 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 545693004554 putative alpha subunit interface [polypeptide binding]; other site 545693004555 putative active site [active] 545693004556 putative substrate binding site [chemical binding]; other site 545693004557 Fe binding site [ion binding]; other site 545693004558 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 545693004559 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 545693004560 Walker A/P-loop; other site 545693004561 ATP binding site [chemical binding]; other site 545693004562 Q-loop/lid; other site 545693004563 ABC transporter signature motif; other site 545693004564 Walker B; other site 545693004565 D-loop; other site 545693004566 H-loop/switch region; other site 545693004567 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 545693004568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004569 dimer interface [polypeptide binding]; other site 545693004570 conserved gate region; other site 545693004571 putative PBP binding loops; other site 545693004572 ABC-ATPase subunit interface; other site 545693004573 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 545693004574 CHASE3 domain; Region: CHASE3; pfam05227 545693004575 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 545693004576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693004577 dimerization interface [polypeptide binding]; other site 545693004578 GAF domain; Region: GAF_2; pfam13185 545693004579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693004580 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693004581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693004582 dimer interface [polypeptide binding]; other site 545693004583 phosphorylation site [posttranslational modification] 545693004584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693004585 ATP binding site [chemical binding]; other site 545693004586 Mg2+ binding site [ion binding]; other site 545693004587 G-X-G motif; other site 545693004588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693004589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004590 active site 545693004591 phosphorylation site [posttranslational modification] 545693004592 intermolecular recognition site; other site 545693004593 dimerization interface [polypeptide binding]; other site 545693004594 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 545693004595 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 545693004596 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 545693004597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693004598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004599 active site 545693004600 phosphorylation site [posttranslational modification] 545693004601 intermolecular recognition site; other site 545693004602 dimerization interface [polypeptide binding]; other site 545693004603 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 545693004604 LysE type translocator; Region: LysE; cl00565 545693004605 amino acid transporter; Region: 2A0306; TIGR00909 545693004606 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693004607 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 545693004608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 545693004609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693004610 ligand binding site [chemical binding]; other site 545693004611 flexible hinge region; other site 545693004612 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 545693004613 putative switch regulator; other site 545693004614 non-specific DNA interactions [nucleotide binding]; other site 545693004615 DNA binding site [nucleotide binding] 545693004616 sequence specific DNA binding site [nucleotide binding]; other site 545693004617 putative cAMP binding site [chemical binding]; other site 545693004618 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 545693004619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693004620 active site 545693004621 motif I; other site 545693004622 motif II; other site 545693004623 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 545693004624 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 545693004625 active site 545693004626 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 545693004627 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693004628 substrate binding [chemical binding]; other site 545693004629 active site 545693004630 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693004631 Ferritin-like domain; Region: Ferritin; pfam00210 545693004632 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 545693004633 dinuclear metal binding motif [ion binding]; other site 545693004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004636 putative substrate translocation pore; other site 545693004637 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 545693004638 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 545693004639 substrate-cofactor binding pocket; other site 545693004640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004641 catalytic residue [active] 545693004642 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693004643 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 545693004644 NAD binding site [chemical binding]; other site 545693004645 homodimer interface [polypeptide binding]; other site 545693004646 active site 545693004647 putative substrate binding site [chemical binding]; other site 545693004648 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 545693004649 hexamer interface [polypeptide binding]; other site 545693004650 RNA binding site [nucleotide binding]; other site 545693004651 Histidine-zinc binding site [chemical binding]; other site 545693004652 benzoate transport; Region: 2A0115; TIGR00895 545693004653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004654 putative substrate translocation pore; other site 545693004655 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693004656 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 545693004657 potential catalytic triad [active] 545693004658 conserved cys residue [active] 545693004659 Uncharacterized conserved protein [Function unknown]; Region: COG1359 545693004660 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 545693004661 NAD binding site [chemical binding]; other site 545693004662 catalytic residues [active] 545693004663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693004664 LysE type translocator; Region: LysE; cl00565 545693004665 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693004666 Spore germination protein; Region: Spore_permease; cl17796 545693004667 YpzG-like protein; Region: YpzG; pfam14139 545693004668 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 545693004669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693004670 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 545693004671 General stress protein [General function prediction only]; Region: GsiB; COG3729 545693004672 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 545693004673 ZIP Zinc transporter; Region: Zip; cl00437 545693004674 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693004675 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693004676 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693004677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693004678 DNA binding site [nucleotide binding] 545693004679 domain linker motif; other site 545693004680 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 545693004681 dimerization interface [polypeptide binding]; other site 545693004682 ligand binding site [chemical binding]; other site 545693004683 sodium binding site [ion binding]; other site 545693004684 galactoside permease; Reviewed; Region: lacY; PRK09528 545693004685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004686 putative substrate translocation pore; other site 545693004687 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 545693004688 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693004689 substrate binding [chemical binding]; other site 545693004690 active site 545693004691 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693004692 hypothetical protein; Validated; Region: PRK00029 545693004693 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 545693004694 active site 545693004695 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 545693004696 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 545693004697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693004698 Walker A motif; other site 545693004699 ATP binding site [chemical binding]; other site 545693004700 Walker B motif; other site 545693004701 arginine finger; other site 545693004702 Transcriptional antiterminator [Transcription]; Region: COG3933 545693004703 PRD domain; Region: PRD; pfam00874 545693004704 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 545693004705 active pocket/dimerization site; other site 545693004706 active site 545693004707 phosphorylation site [posttranslational modification] 545693004708 PRD domain; Region: PRD; pfam00874 545693004709 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 545693004710 active pocket/dimerization site; other site 545693004711 active site 545693004712 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 545693004713 active site 545693004714 phosphorylation site [posttranslational modification] 545693004715 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 545693004716 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 545693004717 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 545693004718 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693004719 substrate binding [chemical binding]; other site 545693004720 active site 545693004721 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 545693004722 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 545693004723 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693004724 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 545693004725 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693004726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004727 dimer interface [polypeptide binding]; other site 545693004728 conserved gate region; other site 545693004729 putative PBP binding loops; other site 545693004730 ABC-ATPase subunit interface; other site 545693004731 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693004732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004733 dimer interface [polypeptide binding]; other site 545693004734 conserved gate region; other site 545693004735 putative PBP binding loops; other site 545693004736 ABC-ATPase subunit interface; other site 545693004737 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693004738 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693004739 substrate binding pocket [chemical binding]; other site 545693004740 membrane-bound complex binding site; other site 545693004741 hinge residues; other site 545693004742 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 545693004743 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 545693004744 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 545693004745 Walker A/P-loop; other site 545693004746 ATP binding site [chemical binding]; other site 545693004747 Q-loop/lid; other site 545693004748 ABC transporter signature motif; other site 545693004749 Walker B; other site 545693004750 D-loop; other site 545693004751 H-loop/switch region; other site 545693004752 NIL domain; Region: NIL; pfam09383 545693004753 ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Region: ectoine_ehuC; TIGR03004 545693004754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004755 dimer interface [polypeptide binding]; other site 545693004756 conserved gate region; other site 545693004757 putative PBP binding loops; other site 545693004758 ABC-ATPase subunit interface; other site 545693004759 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 545693004760 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693004761 active site 545693004762 non-prolyl cis peptide bond; other site 545693004763 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 545693004764 active site 545693004765 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 545693004766 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 545693004767 Serine hydrolase; Region: Ser_hydrolase; cl17834 545693004768 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 545693004769 active site 545693004770 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693004771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693004772 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693004773 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 545693004774 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 545693004775 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693004776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693004777 DNA-binding site [nucleotide binding]; DNA binding site 545693004778 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 545693004779 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 545693004780 putative deacylase active site [active] 545693004781 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693004782 active site 545693004783 catalytic tetrad [active] 545693004784 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 545693004785 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 545693004786 active sites [active] 545693004787 tetramer interface [polypeptide binding]; other site 545693004788 urocanate hydratase; Provisional; Region: PRK05414 545693004789 imidazolonepropionase; Validated; Region: PRK09356 545693004790 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 545693004791 active site 545693004792 Agmatinase-like family; Region: Agmatinase-like; cd09990 545693004793 active site 545693004794 oligomer interface [polypeptide binding]; other site 545693004795 Mn binding site [ion binding]; other site 545693004796 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693004797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693004798 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 545693004799 active site 545693004800 tetramer interface [polypeptide binding]; other site 545693004801 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 545693004802 Predicted membrane protein [Function unknown]; Region: COG1288 545693004803 isoaspartyl dipeptidase; Provisional; Region: PRK10657 545693004804 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693004805 active site 545693004806 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 545693004807 proposed catalytic triad [active] 545693004808 active site nucleophile [active] 545693004809 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 545693004810 proposed catalytic triad [active] 545693004811 active site nucleophile [active] 545693004812 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693004813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693004814 Walker A motif; other site 545693004815 ATP binding site [chemical binding]; other site 545693004816 Walker B motif; other site 545693004817 arginine finger; other site 545693004818 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 545693004819 exopeptidase, frameshift 545693004820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004821 putative substrate translocation pore; other site 545693004822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004823 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 545693004824 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693004825 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 545693004826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004827 Coenzyme A binding pocket [chemical binding]; other site 545693004828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693004829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 545693004830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004831 Coenzyme A binding pocket [chemical binding]; other site 545693004832 Predicted membrane protein [Function unknown]; Region: COG2364 545693004833 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693004834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004835 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693004836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004837 Coenzyme A binding pocket [chemical binding]; other site 545693004838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693004839 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693004840 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693004841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693004842 motif II; other site 545693004843 phosphoenolpyruvate synthase; Validated; Region: PRK06241 545693004844 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 545693004845 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 545693004846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693004847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004850 putative substrate translocation pore; other site 545693004851 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 545693004852 TPP-binding site [chemical binding]; other site 545693004853 dimer interface [polypeptide binding]; other site 545693004854 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 545693004855 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693004856 PYR/PP interface [polypeptide binding]; other site 545693004857 dimer interface [polypeptide binding]; other site 545693004858 TPP binding site [chemical binding]; other site 545693004859 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693004860 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693004861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004862 NAD(P) binding site [chemical binding]; other site 545693004863 active site 545693004864 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693004865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693004866 DNA-binding site [nucleotide binding]; DNA binding site 545693004867 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 545693004868 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 545693004869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004870 putative substrate translocation pore; other site 545693004871 6-phosphofructokinase; Provisional; Region: PRK03202 545693004872 active site 545693004873 ADP/pyrophosphate binding site [chemical binding]; other site 545693004874 dimerization interface [polypeptide binding]; other site 545693004875 allosteric effector site; other site 545693004876 fructose-1,6-bisphosphate binding site; other site 545693004877 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 545693004878 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 545693004879 nudix motif; other site 545693004880 Uncharacterized conserved protein [Function unknown]; Region: COG3339 545693004881 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 545693004882 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693004883 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693004884 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693004885 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693004886 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693004887 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 545693004888 putative active site [active] 545693004889 Protein of unknown function (DUF998); Region: DUF998; pfam06197 545693004890 DinB family; Region: DinB; cl17821 545693004891 phosphoribulokinase/uridine kinase; Region: PLN02318 545693004892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693004894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693004895 dimerization interface [polypeptide binding]; other site 545693004896 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693004897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693004898 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 545693004899 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693004900 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693004901 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 545693004902 classical (c) SDRs; Region: SDR_c; cd05233 545693004903 NAD(P) binding site [chemical binding]; other site 545693004904 active site 545693004905 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 545693004906 active site 545693004907 substrate binding site [chemical binding]; other site 545693004908 ATP binding site [chemical binding]; other site 545693004909 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 545693004910 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 545693004911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693004912 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 545693004913 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693004914 NodB motif; other site 545693004915 putative active site [active] 545693004916 putative catalytic site [active] 545693004917 putative Zn binding site [ion binding]; other site 545693004918 Spore germination protein; Region: Spore_permease; cl17796 545693004919 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 545693004920 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693004921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693004922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693004923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693004924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 545693004925 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 545693004926 calcium/proton exchanger (cax); Region: cax; TIGR00378 545693004927 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693004928 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693004929 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 545693004930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 545693004931 acyl-activating enzyme (AAE) consensus motif; other site 545693004932 AMP binding site [chemical binding]; other site 545693004933 active site 545693004934 CoA binding site [chemical binding]; other site 545693004935 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 545693004936 MMPL family; Region: MMPL; cl14618 545693004937 MMPL family; Region: MMPL; cl14618 545693004938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693004939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693004940 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 545693004941 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 545693004942 Heat induced stress protein YflT; Region: YflT; pfam11181 545693004943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693004944 PAS domain; Region: PAS_9; pfam13426 545693004945 putative active site [active] 545693004946 heme pocket [chemical binding]; other site 545693004947 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693004948 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693004949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693004950 Protein of unknown function (DUF1272); Region: DUF1272; cl19740 545693004951 DinB family; Region: DinB; cl17821 545693004952 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693004953 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693004954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693004956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693004957 dimerization interface [polypeptide binding]; other site 545693004958 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693004959 DNA-binding site [nucleotide binding]; DNA binding site 545693004960 RNA-binding motif; other site 545693004961 Cold-inducible protein YdjO; Region: YdjO; pfam14169 545693004962 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 545693004963 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693004964 ATP binding site [chemical binding]; other site 545693004965 Mg++ binding site [ion binding]; other site 545693004966 motif III; other site 545693004967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693004968 nucleotide binding region [chemical binding]; other site 545693004969 ATP-binding site [chemical binding]; other site 545693004970 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693004971 DNA-binding site [nucleotide binding]; DNA binding site 545693004972 RNA-binding motif; other site 545693004973 Protein of unknown function (DUF3435); Region: DUF3435; pfam11917 545693004974 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693004975 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693004976 acetolactate synthase; Reviewed; Region: PRK08322 545693004977 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693004978 PYR/PP interface [polypeptide binding]; other site 545693004979 dimer interface [polypeptide binding]; other site 545693004980 TPP binding site [chemical binding]; other site 545693004981 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693004982 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 545693004983 TPP-binding site [chemical binding]; other site 545693004984 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 545693004985 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 545693004986 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693004987 Small acid-soluble spore protein H family; Region: SspH; pfam08141 545693004988 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693004989 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 545693004990 substrate binding site [chemical binding]; other site 545693004991 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 545693004992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004993 dimer interface [polypeptide binding]; other site 545693004994 conserved gate region; other site 545693004995 putative PBP binding loops; other site 545693004996 ABC-ATPase subunit interface; other site 545693004997 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693004998 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 545693004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005000 dimer interface [polypeptide binding]; other site 545693005001 conserved gate region; other site 545693005002 putative PBP binding loops; other site 545693005003 ABC-ATPase subunit interface; other site 545693005004 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693005005 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 545693005006 Walker A/P-loop; other site 545693005007 ATP binding site [chemical binding]; other site 545693005008 Q-loop/lid; other site 545693005009 ABC transporter signature motif; other site 545693005010 Walker B; other site 545693005011 D-loop; other site 545693005012 H-loop/switch region; other site 545693005013 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693005014 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 545693005015 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693005016 Walker A/P-loop; other site 545693005017 ATP binding site [chemical binding]; other site 545693005018 Q-loop/lid; other site 545693005019 ABC transporter signature motif; other site 545693005020 Walker B; other site 545693005021 D-loop; other site 545693005022 H-loop/switch region; other site 545693005023 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 545693005024 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 545693005025 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693005026 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693005027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 545693005028 transcriptional regulator, GntR family protein, frameshift 545693005029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693005031 putative substrate translocation pore; other site 545693005032 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 545693005033 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693005034 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693005035 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 545693005036 active site 545693005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693005038 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693005039 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 545693005040 active site 545693005041 catalytic residues [active] 545693005042 metal binding site [ion binding]; metal-binding site 545693005043 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 545693005044 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693005045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693005046 Beta-lactamase; Region: Beta-lactamase; pfam00144 545693005047 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 545693005048 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693005049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005050 S-adenosylmethionine binding site [chemical binding]; other site 545693005051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 545693005052 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693005053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693005054 dimerization interface [polypeptide binding]; other site 545693005055 putative Zn2+ binding site [ion binding]; other site 545693005056 putative DNA binding site [nucleotide binding]; other site 545693005057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693005058 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 545693005059 putative active site [active] 545693005060 catalytic triad [active] 545693005061 putative dimer interface [polypeptide binding]; other site 545693005062 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693005063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693005064 Coenzyme A binding pocket [chemical binding]; other site 545693005065 Chondroitinase B; Region: Chondroitinas_B; pfam14592 545693005066 Right handed beta helix region; Region: Beta_helix; pfam13229 545693005067 recombinase A; Provisional; Region: recA; PRK09354 545693005068 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 545693005069 hexamer interface [polypeptide binding]; other site 545693005070 Walker A motif; other site 545693005071 ATP binding site [chemical binding]; other site 545693005072 Walker B motif; other site 545693005073 Low molecular weight phosphatase family; Region: LMWPc; cd00115 545693005074 active site 545693005075 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 545693005076 Citrate transporter; Region: CitMHS; pfam03600 545693005077 transmembrane helices; other site 545693005078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693005079 dimerization interface [polypeptide binding]; other site 545693005080 putative DNA binding site [nucleotide binding]; other site 545693005081 putative Zn2+ binding site [ion binding]; other site 545693005082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693005083 dimerization interface [polypeptide binding]; other site 545693005084 putative DNA binding site [nucleotide binding]; other site 545693005085 putative Zn2+ binding site [ion binding]; other site 545693005086 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 545693005087 putative metal binding site [ion binding]; other site 545693005088 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 545693005089 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 545693005090 Ligand Binding Site [chemical binding]; other site 545693005091 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693005092 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693005093 active site 545693005094 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 545693005095 Zn binding site [ion binding]; other site 545693005096 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 545693005097 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 545693005098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693005099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693005100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693005101 dimerization interface [polypeptide binding]; other site 545693005102 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693005103 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 545693005104 active site 545693005105 FMN binding site [chemical binding]; other site 545693005106 substrate binding site [chemical binding]; other site 545693005107 putative catalytic residue [active] 545693005108 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 545693005109 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 545693005110 heme binding pocket [chemical binding]; other site 545693005111 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693005112 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693005113 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 545693005114 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693005115 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693005116 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 545693005117 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 545693005118 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 545693005119 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693005120 NAD binding site [chemical binding]; other site 545693005121 catalytic Zn binding site [ion binding]; other site 545693005122 structural Zn binding site [ion binding]; other site 545693005123 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 545693005124 Low molecular weight phosphatase family; Region: LMWPc; cl00105 545693005125 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693005126 PAS domain; Region: PAS_8; pfam13188 545693005127 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693005128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005129 dimer interface [polypeptide binding]; other site 545693005130 phosphorylation site [posttranslational modification] 545693005131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005132 ATP binding site [chemical binding]; other site 545693005133 Mg2+ binding site [ion binding]; other site 545693005134 G-X-G motif; other site 545693005135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693005136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005137 active site 545693005138 phosphorylation site [posttranslational modification] 545693005139 intermolecular recognition site; other site 545693005140 dimerization interface [polypeptide binding]; other site 545693005141 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 545693005142 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 545693005143 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693005144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005145 active site 545693005146 phosphorylation site [posttranslational modification] 545693005147 intermolecular recognition site; other site 545693005148 dimerization interface [polypeptide binding]; other site 545693005149 LytTr DNA-binding domain; Region: LytTR; pfam04397 545693005150 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693005151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693005152 DNA binding site [nucleotide binding] 545693005153 domain linker motif; other site 545693005154 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 545693005155 dimerization interface [polypeptide binding]; other site 545693005156 ligand binding site [chemical binding]; other site 545693005157 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693005158 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693005159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693005160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693005161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693005162 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693005163 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693005164 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693005165 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693005166 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693005167 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 545693005168 polyol permease family; Region: 2A0118; TIGR00897 545693005169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005170 putative substrate translocation pore; other site 545693005171 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 545693005172 classical (c) SDRs; Region: SDR_c; cd05233 545693005173 NAD(P) binding site [chemical binding]; other site 545693005174 active site 545693005175 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 545693005176 Major royal jelly protein; Region: MRJP; pfam03022 545693005177 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 545693005178 Phosphotransferase enzyme family; Region: APH; pfam01636 545693005179 putative active site [active] 545693005180 putative substrate binding site [chemical binding]; other site 545693005181 ATP binding site [chemical binding]; other site 545693005182 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693005183 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693005184 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 545693005185 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 545693005186 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 545693005187 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 545693005188 metal binding site [ion binding]; metal-binding site 545693005189 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 545693005190 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693005191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005192 S-adenosylmethionine binding site [chemical binding]; other site 545693005193 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693005194 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693005195 DNA binding residues [nucleotide binding] 545693005196 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693005197 DNA-binding site [nucleotide binding]; DNA binding site 545693005198 RNA-binding motif; other site 545693005199 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 545693005200 ZIP Zinc transporter; Region: Zip; cl00437 545693005201 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693005202 Spore germination protein; Region: Spore_permease; cl17796 545693005203 Sensory domain found in PocR; Region: PocR; pfam10114 545693005204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693005205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693005206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693005207 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 545693005208 dimer interface [polypeptide binding]; other site 545693005209 active site 545693005210 metal binding site [ion binding]; metal-binding site 545693005211 dihydroxyacetone kinase; Provisional; Region: PRK14479 545693005212 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 545693005213 DAK2 domain; Region: Dak2; pfam02734 545693005214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693005215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693005216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005217 classical (c) SDRs; Region: SDR_c; cd05233 545693005218 NAD(P) binding site [chemical binding]; other site 545693005219 active site 545693005220 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005222 NAD(P) binding site [chemical binding]; other site 545693005223 active site 545693005224 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005225 classical (c) SDRs; Region: SDR_c; cd05233 545693005226 NAD(P) binding site [chemical binding]; other site 545693005227 active site 545693005228 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 545693005229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693005230 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 545693005231 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693005232 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693005233 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693005234 putative reverse transcriptase, point mutation 545693005235 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 545693005236 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693005237 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 545693005238 Cation transport protein; Region: TrkH; cl17365 545693005239 Cation transport protein; Region: TrkH; cl17365 545693005240 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 545693005241 Spore germination protein; Region: Spore_permease; pfam03845 545693005242 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693005243 DNA-binding site [nucleotide binding]; DNA binding site 545693005244 RNA-binding motif; other site 545693005245 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 545693005246 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693005247 active site 545693005248 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693005249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005250 DNA-binding site [nucleotide binding]; DNA binding site 545693005251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693005253 homodimer interface [polypeptide binding]; other site 545693005254 catalytic residue [active] 545693005255 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693005256 EamA-like transporter family; Region: EamA; pfam00892 545693005257 EamA-like transporter family; Region: EamA; pfam00892 545693005258 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 545693005259 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693005260 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 545693005261 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693005262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005263 S-adenosylmethionine binding site [chemical binding]; other site 545693005264 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693005265 catalytic triad [active] 545693005266 conserved cis-peptide bond; other site 545693005267 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693005268 catalytic triad [active] 545693005269 conserved cis-peptide bond; other site 545693005270 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 545693005271 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 545693005272 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693005273 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693005274 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 545693005275 DNA polymerase IV; Reviewed; Region: PRK03103 545693005276 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 545693005277 active site 545693005278 DNA binding site [nucleotide binding] 545693005279 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 545693005280 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 545693005281 putative active site [active] 545693005282 putative NTP binding site [chemical binding]; other site 545693005283 putative nucleic acid binding site [nucleotide binding]; other site 545693005284 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 545693005285 active site 545693005286 YolD-like protein; Region: YolD; pfam08863 545693005287 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693005288 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 545693005289 phosphate binding motif [ion binding]; other site 545693005290 beta-alpha-beta structure motif; other site 545693005291 NAD binding pocket [chemical binding]; other site 545693005292 phosphoenolpyruvate synthase; Validated; Region: PRK06241 545693005293 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 545693005294 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 545693005295 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 545693005296 putative deacylase active site [active] 545693005297 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 545693005298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005299 putative substrate translocation pore; other site 545693005300 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693005301 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 545693005302 tetrameric interface [polypeptide binding]; other site 545693005303 activator binding site; other site 545693005304 NADP binding site [chemical binding]; other site 545693005305 substrate binding site [chemical binding]; other site 545693005306 catalytic residues [active] 545693005307 RNAPII transcription regulator C-terminal; Region: MMS19_C; pfam12460 545693005308 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693005309 active site 545693005310 intersubunit interactions; other site 545693005311 catalytic residue [active] 545693005312 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 545693005313 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 545693005314 DinB superfamily; Region: DinB_2; pfam12867 545693005315 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 545693005316 active site 545693005317 catalytic residues [active] 545693005318 FOG: CBS domain [General function prediction only]; Region: COG0517 545693005319 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 545693005320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 545693005321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693005322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693005323 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693005324 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 545693005325 putative DNA binding site [nucleotide binding]; other site 545693005326 putative Zn2+ binding site [ion binding]; other site 545693005327 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 545693005328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 545693005329 nucleotide binding site [chemical binding]; other site 545693005330 xylose isomerase; Provisional; Region: PRK05474 545693005331 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 545693005332 N- and C-terminal domain interface [polypeptide binding]; other site 545693005333 D-xylulose kinase; Region: XylB; TIGR01312 545693005334 active site 545693005335 MgATP binding site [chemical binding]; other site 545693005336 catalytic site [active] 545693005337 metal binding site [ion binding]; metal-binding site 545693005338 xylulose binding site [chemical binding]; other site 545693005339 homodimer interface [polypeptide binding]; other site 545693005340 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 545693005341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005342 putative substrate translocation pore; other site 545693005343 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 545693005344 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 545693005345 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 545693005346 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 545693005347 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 545693005348 D-pathway; other site 545693005349 Putative ubiquinol binding site [chemical binding]; other site 545693005350 Low-spin heme (heme b) binding site [chemical binding]; other site 545693005351 Putative water exit pathway; other site 545693005352 Binuclear center (heme o3/CuB) [ion binding]; other site 545693005353 K-pathway; other site 545693005354 Putative proton exit pathway; other site 545693005355 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 545693005356 Subunit I/III interface [polypeptide binding]; other site 545693005357 Subunit III/IV interface [polypeptide binding]; other site 545693005358 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 545693005359 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693005360 Ligand Binding Site [chemical binding]; other site 545693005361 oxidoreductase; Provisional; Region: PRK07985 545693005362 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 545693005363 NAD binding site [chemical binding]; other site 545693005364 metal binding site [ion binding]; metal-binding site 545693005365 active site 545693005366 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 545693005367 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 545693005368 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 545693005369 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693005370 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693005371 Citrate transporter; Region: CitMHS; pfam03600 545693005372 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 545693005373 transmembrane helices; other site 545693005374 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 545693005375 tetramer interface [polypeptide binding]; other site 545693005376 TPP-binding site [chemical binding]; other site 545693005377 heterodimer interface [polypeptide binding]; other site 545693005378 phosphorylation loop region [posttranslational modification] 545693005379 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 545693005380 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 545693005381 alpha subunit interface [polypeptide binding]; other site 545693005382 TPP binding site [chemical binding]; other site 545693005383 heterodimer interface [polypeptide binding]; other site 545693005384 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693005385 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 545693005386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693005387 E3 interaction surface; other site 545693005388 lipoyl attachment site [posttranslational modification]; other site 545693005389 e3 binding domain; Region: E3_binding; pfam02817 545693005390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 545693005391 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 545693005392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693005393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693005394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693005395 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 545693005396 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 545693005397 GAF domain; Region: GAF; pfam01590 545693005398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693005399 Walker A motif; other site 545693005400 ATP binding site [chemical binding]; other site 545693005401 Walker B motif; other site 545693005402 arginine finger; other site 545693005403 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 545693005404 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693005405 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 545693005406 putative NAD(P) binding site [chemical binding]; other site 545693005407 catalytic Zn binding site [ion binding]; other site 545693005408 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693005409 homodimer interface [polypeptide binding]; other site 545693005410 substrate-cofactor binding pocket; other site 545693005411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693005412 catalytic residue [active] 545693005413 transcriptional regulator Hpr; Provisional; Region: PRK13777 545693005414 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693005415 galactarate dehydratase; Region: galactar-dH20; TIGR03248 545693005416 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 545693005417 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 545693005418 Propionate catabolism activator; Region: PrpR_N; pfam06506 545693005419 PAS domain S-box; Region: sensory_box; TIGR00229 545693005420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693005421 putative active site [active] 545693005422 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693005423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693005424 Walker A motif; other site 545693005425 ATP binding site [chemical binding]; other site 545693005426 Walker B motif; other site 545693005427 arginine finger; other site 545693005428 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 545693005429 Class I aldolases; Region: Aldolase_Class_I; cl17187 545693005430 catalytic residue [active] 545693005431 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 545693005432 NAD(P) binding site [chemical binding]; other site 545693005433 catalytic residues [active] 545693005434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005435 D-galactonate transporter; Region: 2A0114; TIGR00893 545693005436 putative substrate translocation pore; other site 545693005437 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 545693005438 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 545693005439 active site 545693005440 tetramer interface [polypeptide binding]; other site 545693005441 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693005442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005443 DNA-binding site [nucleotide binding]; DNA binding site 545693005444 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 545693005445 DNA topoisomerase VI subunit B; Provisional; Region: PRK14867 545693005446 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693005447 active site 545693005448 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 545693005449 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 545693005450 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 545693005451 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 545693005452 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 545693005453 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 545693005454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005455 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 545693005456 putative substrate translocation pore; other site 545693005457 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 545693005458 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 545693005459 IDEAL domain; Region: IDEAL; pfam08858 545693005460 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693005461 Ligand Binding Site [chemical binding]; other site 545693005462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693005463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693005464 dimerization interface [polypeptide binding]; other site 545693005465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005466 dimer interface [polypeptide binding]; other site 545693005467 phosphorylation site [posttranslational modification] 545693005468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005469 ATP binding site [chemical binding]; other site 545693005470 Mg2+ binding site [ion binding]; other site 545693005471 G-X-G motif; other site 545693005472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693005473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005474 active site 545693005475 phosphorylation site [posttranslational modification] 545693005476 intermolecular recognition site; other site 545693005477 dimerization interface [polypeptide binding]; other site 545693005478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693005479 DNA binding site [nucleotide binding] 545693005480 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 545693005481 putative homodimer interface [polypeptide binding]; other site 545693005482 putative homotetramer interface [polypeptide binding]; other site 545693005483 allosteric switch controlling residues; other site 545693005484 putative metal binding site [ion binding]; other site 545693005485 putative homodimer-homodimer interface [polypeptide binding]; other site 545693005486 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693005487 metal-binding site [ion binding] 545693005488 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693005489 metal-binding site [ion binding] 545693005490 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693005491 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693005492 metal-binding site [ion binding] 545693005493 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693005494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005495 motif II; other site 545693005496 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693005497 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 545693005498 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 545693005499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005500 D-galactonate transporter; Region: 2A0114; TIGR00893 545693005501 putative substrate translocation pore; other site 545693005502 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 545693005503 catalytic loop [active] 545693005504 iron binding site [ion binding]; other site 545693005505 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693005506 YibE/F-like protein; Region: YibE_F; pfam07907 545693005507 YibE/F-like protein; Region: YibE_F; pfam07907 545693005508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693005509 dimerization interface [polypeptide binding]; other site 545693005510 putative DNA binding site [nucleotide binding]; other site 545693005511 putative Zn2+ binding site [ion binding]; other site 545693005512 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 545693005513 transmembrane helices; other site 545693005514 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 545693005515 active site 545693005516 metal binding site [ion binding]; metal-binding site 545693005517 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 545693005518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693005519 catalytic core [active] 545693005520 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 545693005521 Phosphotransferase enzyme family; Region: APH; pfam01636 545693005522 active site 545693005523 substrate binding site [chemical binding]; other site 545693005524 ATP binding site [chemical binding]; other site 545693005525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 545693005526 Transposase; Region: DEDD_Tnp_IS110; pfam01548 545693005527 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 545693005528 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 545693005529 putative active site [active] 545693005530 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693005531 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693005532 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 545693005533 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693005534 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 545693005535 stage V sporulation protein AD; Provisional; Region: PRK12404 545693005536 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 545693005537 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 545693005538 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 545693005539 Predicted membrane protein [Function unknown]; Region: COG2323 545693005540 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 545693005541 Predicted membrane protein [Function unknown]; Region: COG2323 545693005542 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 545693005543 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693005544 oligomer interface [polypeptide binding]; other site 545693005545 metal binding site [ion binding]; metal-binding site 545693005546 metal binding site [ion binding]; metal-binding site 545693005547 putative Cl binding site [ion binding]; other site 545693005548 aspartate ring; other site 545693005549 basic sphincter; other site 545693005550 hydrophobic gate; other site 545693005551 periplasmic entrance; other site 545693005552 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693005553 EamA-like transporter family; Region: EamA; pfam00892 545693005554 EamA-like transporter family; Region: EamA; pfam00892 545693005555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693005556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693005557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693005558 dimerization interface [polypeptide binding]; other site 545693005559 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 545693005560 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 545693005561 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693005562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693005563 non-specific DNA binding site [nucleotide binding]; other site 545693005564 salt bridge; other site 545693005565 sequence-specific DNA binding site [nucleotide binding]; other site 545693005566 T5orf172 domain; Region: T5orf172; pfam10544 545693005567 DNA topoisomerase III; Provisional; Region: PRK07726 545693005568 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 545693005569 active site 545693005570 putative interdomain interaction site [polypeptide binding]; other site 545693005571 putative metal-binding site [ion binding]; other site 545693005572 putative nucleotide binding site [chemical binding]; other site 545693005573 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693005574 domain I; other site 545693005575 DNA binding groove [nucleotide binding] 545693005576 phosphate binding site [ion binding]; other site 545693005577 domain II; other site 545693005578 domain III; other site 545693005579 nucleotide binding site [chemical binding]; other site 545693005580 catalytic site [active] 545693005581 domain IV; other site 545693005582 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 545693005583 Uncharacterized conserved protein [Function unknown]; Region: COG5444 545693005584 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 545693005585 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 545693005586 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693005587 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 545693005588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693005589 AAA domain; Region: AAA_21; pfam13304 545693005590 Walker A/P-loop; other site 545693005591 ATP binding site [chemical binding]; other site 545693005592 AAA domain; Region: AAA_21; pfam13304 545693005593 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693005594 domain IV; other site 545693005595 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 545693005596 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 545693005597 CoenzymeA binding site [chemical binding]; other site 545693005598 subunit interaction site [polypeptide binding]; other site 545693005599 PHB binding site; other site 545693005600 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 545693005601 nudix motif; other site 545693005602 Predicted membrane protein [Function unknown]; Region: COG2323 545693005603 Tannase and feruloyl esterase; Region: Tannase; pfam07519 545693005604 Predicted permeases [General function prediction only]; Region: COG0679 545693005605 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693005606 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693005607 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693005608 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005610 DNA-binding site [nucleotide binding]; DNA binding site 545693005611 FCD domain; Region: FCD; pfam07729 545693005612 tartrate dehydrogenase; Provisional; Region: PRK08194 545693005613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693005615 putative substrate translocation pore; other site 545693005616 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 545693005617 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 545693005618 dimerization interface [polypeptide binding]; other site 545693005619 active site 545693005620 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 545693005621 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 545693005622 catalytic motif [active] 545693005623 Zn binding site [ion binding]; other site 545693005624 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 545693005625 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693005626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693005627 non-specific DNA binding site [nucleotide binding]; other site 545693005628 salt bridge; other site 545693005629 sequence-specific DNA binding site [nucleotide binding]; other site 545693005630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693005631 binding surface 545693005632 TPR motif; other site 545693005633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693005634 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 545693005635 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 545693005636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005637 S-adenosylmethionine binding site [chemical binding]; other site 545693005638 Mor transcription activator family; Region: Mor; cl02360 545693005639 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 545693005640 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 545693005641 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 545693005642 active site residue [active] 545693005643 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 545693005644 active site residue [active] 545693005645 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 545693005646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005647 active site 545693005648 motif I; other site 545693005649 motif II; other site 545693005650 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693005651 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 545693005652 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693005653 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693005654 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 545693005655 NodB motif; other site 545693005656 active site 545693005657 catalytic site [active] 545693005658 metal binding site [ion binding]; metal-binding site 545693005659 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 545693005660 proposed active site lysine [active] 545693005661 conserved cys residue [active] 545693005662 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 545693005663 Potassium binding sites [ion binding]; other site 545693005664 Cesium cation binding sites [ion binding]; other site 545693005665 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 545693005666 catalytic residues [active] 545693005667 dimer interface [polypeptide binding]; other site 545693005668 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 545693005669 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693005670 Zn2+ binding site [ion binding]; other site 545693005671 Mg2+ binding site [ion binding]; other site 545693005672 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693005673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693005674 ABC transporter; Region: ABC_tran_2; pfam12848 545693005675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693005676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693005677 Walker A/P-loop; other site 545693005678 ATP binding site [chemical binding]; other site 545693005679 Q-loop/lid; other site 545693005680 ABC transporter signature motif; other site 545693005681 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 545693005682 Virulence factor; Region: Virulence_fact; pfam13769 545693005683 HEAT repeats; Region: HEAT_2; pfam13646 545693005684 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 545693005685 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 545693005686 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 545693005687 NodB motif; other site 545693005688 active site 545693005689 catalytic site [active] 545693005690 Zn binding site [ion binding]; other site 545693005691 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 545693005692 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 545693005693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005694 YpjP-like protein; Region: YpjP; pfam14005 545693005695 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693005696 catalytic residues [active] 545693005697 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 545693005698 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 545693005699 putative binding site residues; other site 545693005700 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 545693005701 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 545693005702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693005703 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 545693005704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693005705 homodimer interface [polypeptide binding]; other site 545693005706 catalytic residue [active] 545693005707 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 545693005708 cobalamin synthase; Reviewed; Region: cobS; PRK00235 545693005709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693005710 catalytic core [active] 545693005711 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 545693005712 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 545693005713 Predicted permeases [General function prediction only]; Region: RarD; COG2962 545693005714 EamA-like transporter family; Region: EamA; pfam00892 545693005715 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693005716 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 545693005717 DNA binding residues [nucleotide binding] 545693005718 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 545693005719 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 545693005720 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 545693005721 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 545693005722 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 545693005723 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 545693005724 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 545693005725 GIY-YIG motif/motif A; other site 545693005726 active site 545693005727 catalytic site [active] 545693005728 metal binding site [ion binding]; metal-binding site 545693005729 5'-3' exonuclease; Region: 53EXOc; smart00475 545693005730 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 545693005731 active site 545693005732 metal binding site 1 [ion binding]; metal-binding site 545693005733 putative 5' ssDNA interaction site; other site 545693005734 metal binding site 3; metal-binding site 545693005735 metal binding site 2 [ion binding]; metal-binding site 545693005736 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 545693005737 putative DNA binding site [nucleotide binding]; other site 545693005738 putative metal binding site [ion binding]; other site 545693005739 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 545693005740 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 545693005741 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 545693005742 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 545693005743 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 545693005744 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 545693005745 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 545693005746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693005747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693005748 DNA binding residues [nucleotide binding] 545693005749 Putative zinc-finger; Region: zf-HC2; pfam13490 545693005750 Anti-sigma-K factor rskA; Region: RskA; pfam10099 545693005751 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693005752 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693005753 putative dimer interface [polypeptide binding]; other site 545693005754 Replication terminator protein; Region: RTP; pfam02334 545693005755 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693005756 multidrug efflux protein; Reviewed; Region: PRK01766 545693005757 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 545693005758 cation binding site [ion binding]; other site 545693005759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005760 classical (c) SDRs; Region: SDR_c; cd05233 545693005761 NAD(P) binding site [chemical binding]; other site 545693005762 active site 545693005763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693005764 phytoene desaturase; Region: crtI_fam; TIGR02734 545693005765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693005766 active site 545693005767 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 545693005768 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693005769 Sulfatase; Region: Sulfatase; pfam00884 545693005770 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 545693005771 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 545693005772 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 545693005773 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693005774 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 545693005775 NodB motif; other site 545693005776 active site 545693005777 catalytic site [active] 545693005778 metal binding site [ion binding]; metal-binding site 545693005779 potassium/proton antiporter; Reviewed; Region: PRK05326 545693005780 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 545693005781 TrkA-C domain; Region: TrkA_C; pfam02080 545693005782 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 545693005783 PA/protease domain interface [polypeptide binding]; other site 545693005784 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 545693005785 putative integrin binding motif; other site 545693005786 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 545693005787 metal binding site [ion binding]; metal-binding site 545693005788 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693005789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005790 dimer interface [polypeptide binding]; other site 545693005791 phosphorylation site [posttranslational modification] 545693005792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005793 ATP binding site [chemical binding]; other site 545693005794 Mg2+ binding site [ion binding]; other site 545693005795 G-X-G motif; other site 545693005796 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 545693005797 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 545693005798 carbohydrate binding site [chemical binding]; other site 545693005799 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 545693005800 carbohydrate binding site [chemical binding]; other site 545693005801 pullulanase, type I; Region: pulA_typeI; TIGR02104 545693005802 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 545693005803 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 545693005804 Ca binding site [ion binding]; other site 545693005805 active site 545693005806 catalytic site [active] 545693005807 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 545693005808 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 545693005809 NAD(P) binding site [chemical binding]; other site 545693005810 catalytic residues [active] 545693005811 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 545693005812 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693005813 active site 545693005814 ATP binding site [chemical binding]; other site 545693005815 substrate binding site [chemical binding]; other site 545693005816 flagellar motor protein MotA; Validated; Region: PRK08124 545693005817 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 545693005818 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 545693005819 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 545693005820 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 545693005821 ligand binding site [chemical binding]; other site 545693005822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693005823 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 545693005824 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 545693005825 SelR domain; Region: SelR; cl15841 545693005826 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 545693005827 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693005828 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 545693005829 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693005830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005831 DNA-binding site [nucleotide binding]; DNA binding site 545693005832 FCD domain; Region: FCD; pfam07729 545693005833 S-methylmethionine transporter; Provisional; Region: PRK11387 545693005834 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693005835 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 545693005836 SurA N-terminal domain; Region: SurA_N; pfam09312 545693005837 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 545693005838 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693005839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005840 active site 545693005841 phosphorylation site [posttranslational modification] 545693005842 intermolecular recognition site; other site 545693005843 dimerization interface [polypeptide binding]; other site 545693005844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693005845 DNA binding site [nucleotide binding] 545693005846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005847 dimer interface [polypeptide binding]; other site 545693005848 phosphorylation site [posttranslational modification] 545693005849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 545693005850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005851 ATP binding site [chemical binding]; other site 545693005852 Mg2+ binding site [ion binding]; other site 545693005853 G-X-G motif; other site 545693005854 allantoinase; Provisional; Region: PRK06189 545693005855 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693005856 active site 545693005857 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 545693005858 POT family; Region: PTR2; cl17359 545693005859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005860 putative substrate translocation pore; other site 545693005861 malate dehydrogenase; Provisional; Region: PRK13529 545693005862 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693005863 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 545693005864 NAD(P) binding site [chemical binding]; other site 545693005865 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 545693005866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005867 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693005868 motif II; other site 545693005869 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693005870 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 545693005871 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 545693005872 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693005873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693005874 Coenzyme A binding pocket [chemical binding]; other site 545693005875 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 545693005876 catalytic residues [active] 545693005877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693005878 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693005879 substrate binding pocket [chemical binding]; other site 545693005880 membrane-bound complex binding site; other site 545693005881 hinge residues; other site 545693005882 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693005883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005884 dimer interface [polypeptide binding]; other site 545693005885 conserved gate region; other site 545693005886 putative PBP binding loops; other site 545693005887 ABC-ATPase subunit interface; other site 545693005888 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693005889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005890 dimer interface [polypeptide binding]; other site 545693005891 conserved gate region; other site 545693005892 putative PBP binding loops; other site 545693005893 ABC-ATPase subunit interface; other site 545693005894 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693005895 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 545693005896 Walker A/P-loop; other site 545693005897 ATP binding site [chemical binding]; other site 545693005898 Q-loop/lid; other site 545693005899 ABC transporter signature motif; other site 545693005900 Walker B; other site 545693005901 D-loop; other site 545693005902 H-loop/switch region; other site 545693005903 Riboflavin kinase; Region: Flavokinase; pfam01687 545693005904 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693005905 active site 545693005906 non-prolyl cis peptide bond; other site 545693005907 Fimbrial assembly protein (PilN); Region: PilN; cl19830 545693005908 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693005909 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693005910 active site 545693005911 metal binding site [ion binding]; metal-binding site 545693005912 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 545693005913 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 545693005914 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 545693005915 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 545693005916 amidase catalytic site [active] 545693005917 Zn binding residues [ion binding]; other site 545693005918 substrate binding site [chemical binding]; other site 545693005919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693005920 Coenzyme A binding pocket [chemical binding]; other site 545693005921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693005922 ZIP Zinc transporter; Region: Zip; cl00437 545693005923 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 545693005924 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 545693005925 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 545693005926 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 545693005927 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693005928 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 545693005929 NAD(P) binding pocket [chemical binding]; other site 545693005930 Bacterial PH domain; Region: bPH_2; cl01348 545693005931 Predicted membrane protein [Function unknown]; Region: COG3428 545693005932 Bacterial PH domain; Region: bPH_2; pfam03703 545693005933 Bacterial PH domain; Region: bPH_2; pfam03703 545693005934 Bacterial PH domain; Region: bPH_2; pfam03703 545693005935 D-serine dehydratase; Provisional; Region: PRK02991 545693005936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693005937 catalytic residue [active] 545693005938 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 545693005939 putative substrate binding site [chemical binding]; other site 545693005940 putative ATP binding site [chemical binding]; other site 545693005941 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 545693005942 putative active site [active] 545693005943 Protein of unknown function (DUF867); Region: DUF867; pfam05908 545693005944 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693005945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005946 S-adenosylmethionine binding site [chemical binding]; other site 545693005947 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693005948 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693005949 DNA binding residues [nucleotide binding] 545693005950 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 545693005951 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 545693005952 Small acid-soluble spore protein H family; Region: SspH; cl06949 545693005953 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 545693005954 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 545693005955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693005956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693005957 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693005958 putative dimerization interface [polypeptide binding]; other site 545693005959 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 545693005960 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 545693005961 active site 545693005962 dimer interface [polypeptide binding]; other site 545693005963 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 545693005964 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 545693005965 active site 545693005966 FMN binding site [chemical binding]; other site 545693005967 substrate binding site [chemical binding]; other site 545693005968 3Fe-4S cluster binding site [ion binding]; other site 545693005969 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 545693005970 domain interface; other site 545693005971 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 545693005972 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 545693005973 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 545693005974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 545693005975 Staygreen protein; Region: Staygreen; pfam12638 545693005976 Tannase and feruloyl esterase; Region: Tannase; pfam07519 545693005977 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 545693005978 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 545693005979 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 545693005980 homodimer interface [polypeptide binding]; other site 545693005981 NADP binding site [chemical binding]; other site 545693005982 substrate binding site [chemical binding]; other site 545693005983 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 545693005984 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693005985 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 545693005986 PLD-like domain; Region: PLDc_2; pfam13091 545693005987 putative active site [active] 545693005988 catalytic site [active] 545693005989 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 545693005990 PLD-like domain; Region: PLDc_2; pfam13091 545693005991 putative active site [active] 545693005992 catalytic site [active] 545693005993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693005994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693005995 Coenzyme A binding pocket [chemical binding]; other site 545693005996 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693005997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693005998 LrgA family; Region: LrgA; cl00608 545693005999 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 545693006000 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693006001 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693006002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693006003 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 545693006004 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 545693006005 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 545693006006 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 545693006007 Ligand binding site; other site 545693006008 Putative Catalytic site; other site 545693006009 DXD motif; other site 545693006010 GtrA-like protein; Region: GtrA; pfam04138 545693006011 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693006012 active site 545693006013 tetramer interface; other site 545693006014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693006015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693006016 active site 545693006017 phosphorylation site [posttranslational modification] 545693006018 intermolecular recognition site; other site 545693006019 dimerization interface [polypeptide binding]; other site 545693006020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693006021 DNA binding site [nucleotide binding] 545693006022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693006023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693006024 dimerization interface [polypeptide binding]; other site 545693006025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006026 dimer interface [polypeptide binding]; other site 545693006027 phosphorylation site [posttranslational modification] 545693006028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006029 ATP binding site [chemical binding]; other site 545693006030 Mg2+ binding site [ion binding]; other site 545693006031 G-X-G motif; other site 545693006032 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 545693006033 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693006034 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 545693006035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693006036 substrate binding pocket [chemical binding]; other site 545693006037 membrane-bound complex binding site; other site 545693006038 hinge residues; other site 545693006039 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 545693006040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693006041 dimer interface [polypeptide binding]; other site 545693006042 conserved gate region; other site 545693006043 putative PBP binding loops; other site 545693006044 ABC-ATPase subunit interface; other site 545693006045 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 545693006046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693006047 dimer interface [polypeptide binding]; other site 545693006048 conserved gate region; other site 545693006049 putative PBP binding loops; other site 545693006050 ABC-ATPase subunit interface; other site 545693006051 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 545693006052 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 545693006053 Walker A/P-loop; other site 545693006054 ATP binding site [chemical binding]; other site 545693006055 Q-loop/lid; other site 545693006056 ABC transporter signature motif; other site 545693006057 Walker B; other site 545693006058 D-loop; other site 545693006059 H-loop/switch region; other site 545693006060 TOBE-like domain; Region: TOBE_3; pfam12857 545693006061 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 545693006062 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 545693006063 dimer interface [polypeptide binding]; other site 545693006064 active site 545693006065 CoA binding pocket [chemical binding]; other site 545693006066 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693006067 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693006068 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693006069 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693006070 YolD-like protein; Region: YolD; pfam08863 545693006071 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693006072 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 545693006073 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 545693006074 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 545693006075 putative substrate binding site [chemical binding]; other site 545693006076 putative ATP binding site [chemical binding]; other site 545693006077 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 545693006078 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693006079 active site 545693006080 phosphorylation site [posttranslational modification] 545693006081 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 545693006082 active site 545693006083 P-loop; other site 545693006084 phosphorylation site [posttranslational modification] 545693006085 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 545693006086 aspartate kinase; Reviewed; Region: PRK09034 545693006087 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 545693006088 putative catalytic residues [active] 545693006089 putative nucleotide binding site [chemical binding]; other site 545693006090 putative aspartate binding site [chemical binding]; other site 545693006091 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 545693006092 allosteric regulatory residue; other site 545693006093 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 545693006094 YusW-like protein; Region: YusW; pfam14039 545693006095 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 545693006096 E-class dimer interface [polypeptide binding]; other site 545693006097 P-class dimer interface [polypeptide binding]; other site 545693006098 active site 545693006099 Cu2+ binding site [ion binding]; other site 545693006100 Zn2+ binding site [ion binding]; other site 545693006101 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 545693006102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693006103 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 545693006104 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693006105 DNA binding residues [nucleotide binding] 545693006106 dimer interface [polypeptide binding]; other site 545693006107 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693006108 classical (c) SDRs; Region: SDR_c; cd05233 545693006109 NAD(P) binding site [chemical binding]; other site 545693006110 active site 545693006111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693006112 dimerization interface [polypeptide binding]; other site 545693006113 putative DNA binding site [nucleotide binding]; other site 545693006114 putative Zn2+ binding site [ion binding]; other site 545693006115 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 545693006116 NAD(P) binding site [chemical binding]; other site 545693006117 catalytic residues [active] 545693006118 Putative transcription activator [Transcription]; Region: TenA; COG0819 545693006119 TspO/MBR family; Region: TspO_MBR; cl01379 545693006120 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 545693006121 Na2 binding site [ion binding]; other site 545693006122 putative substrate binding site 1 [chemical binding]; other site 545693006123 Na binding site 1 [ion binding]; other site 545693006124 putative substrate binding site 2 [chemical binding]; other site 545693006125 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 545693006126 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693006127 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693006128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693006129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693006130 DNA binding site [nucleotide binding] 545693006131 domain linker motif; other site 545693006132 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693006133 dimerization interface [polypeptide binding]; other site 545693006134 ligand binding site [chemical binding]; other site 545693006135 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 545693006136 conserved cys residue [active] 545693006137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693006138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693006139 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693006140 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693006141 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693006142 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693006143 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693006144 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693006145 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 545693006146 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 545693006147 active site 545693006148 DNA binding site [nucleotide binding] 545693006149 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 545693006150 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693006151 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693006152 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693006153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693006154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006155 Coenzyme A binding pocket [chemical binding]; other site 545693006156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693006157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693006158 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 545693006159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006160 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693006161 putative substrate translocation pore; other site 545693006162 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 545693006163 substrate binding site [chemical binding]; other site 545693006164 multimerization interface [polypeptide binding]; other site 545693006165 ATP binding site [chemical binding]; other site 545693006166 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 545693006167 thiamine phosphate binding site [chemical binding]; other site 545693006168 active site 545693006169 pyrophosphate binding site [ion binding]; other site 545693006170 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 545693006171 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 545693006172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693006173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693006174 non-specific DNA binding site [nucleotide binding]; other site 545693006175 salt bridge; other site 545693006176 sequence-specific DNA binding site [nucleotide binding]; other site 545693006177 Putative zinc-finger; Region: zf-HC2; pfam13490 545693006178 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 545693006179 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 545693006180 RNA polymerase sigma factor; Provisional; Region: PRK12541 545693006181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693006182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693006183 DNA binding residues [nucleotide binding] 545693006184 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 545693006185 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 545693006186 MoxR-like ATPases [General function prediction only]; Region: COG0714 545693006187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693006188 Walker A motif; other site 545693006189 Walker A motif; other site 545693006190 ATP binding site [chemical binding]; other site 545693006191 Walker B motif; other site 545693006192 arginine finger; other site 545693006193 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 545693006194 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 545693006195 metal ion-dependent adhesion site (MIDAS); other site 545693006196 EamA-like transporter family; Region: EamA; pfam00892 545693006197 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693006198 EamA-like transporter family; Region: EamA; pfam00892 545693006199 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 545693006200 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 545693006201 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 545693006202 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 545693006203 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 545693006204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 545693006205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693006206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693006207 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 545693006208 active site 545693006209 putative substrate binding region [chemical binding]; other site 545693006210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693006211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693006212 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693006213 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 545693006214 Walker A/P-loop; other site 545693006215 ATP binding site [chemical binding]; other site 545693006216 Q-loop/lid; other site 545693006217 ABC transporter signature motif; other site 545693006218 Walker B; other site 545693006219 D-loop; other site 545693006220 H-loop/switch region; other site 545693006221 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693006222 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 545693006223 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 545693006224 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 545693006225 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 545693006226 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 545693006227 active site 545693006228 putative carbohydrate kinase; Provisional; Region: PRK10565 545693006229 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 545693006230 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 545693006231 putative substrate binding site [chemical binding]; other site 545693006232 putative ATP binding site [chemical binding]; other site 545693006233 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 545693006234 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 545693006235 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 545693006236 hypothetical protein; Provisional; Region: PRK10621 545693006237 Predicted transcriptional regulators [Transcription]; Region: COG1378 545693006238 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 545693006239 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 545693006240 C-terminal domain interface [polypeptide binding]; other site 545693006241 sugar binding site [chemical binding]; other site 545693006242 azoreductase; Reviewed; Region: PRK00170 545693006243 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693006244 classical (c) SDRs; Region: SDR_c; cd05233 545693006245 NAD(P) binding site [chemical binding]; other site 545693006246 active site 545693006247 ribosomal RNA adenine dimethylase, point mutation 545693006248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693006249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693006250 active site 545693006251 phosphorylation site [posttranslational modification] 545693006252 intermolecular recognition site; other site 545693006253 dimerization interface [polypeptide binding]; other site 545693006254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693006255 DNA binding site [nucleotide binding] 545693006256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693006257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693006258 dimerization interface [polypeptide binding]; other site 545693006259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006260 dimer interface [polypeptide binding]; other site 545693006261 phosphorylation site [posttranslational modification] 545693006262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006263 ATP binding site [chemical binding]; other site 545693006264 Mg2+ binding site [ion binding]; other site 545693006265 G-X-G motif; other site 545693006266 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693006267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006268 DNA-binding site [nucleotide binding]; DNA binding site 545693006269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693006270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006271 homodimer interface [polypeptide binding]; other site 545693006272 catalytic residue [active] 545693006273 Lysine efflux permease [General function prediction only]; Region: COG1279 545693006274 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 545693006275 active site 545693006276 metal binding site [ion binding]; metal-binding site 545693006277 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 545693006278 DinB superfamily; Region: DinB_2; pfam12867 545693006279 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693006280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693006281 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 545693006282 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 545693006283 Anti-repressor SinI; Region: SinI; pfam08671 545693006284 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693006285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693006286 non-specific DNA binding site [nucleotide binding]; other site 545693006287 salt bridge; other site 545693006288 sequence-specific DNA binding site [nucleotide binding]; other site 545693006289 Anti-repressor SinI; Region: SinI; pfam08671 545693006290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693006291 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 545693006292 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 545693006293 nudix motif; other site 545693006294 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 545693006295 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 545693006296 catalytic triad [active] 545693006297 conserved cis-peptide bond; other site 545693006298 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 545693006299 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 545693006300 active site 545693006301 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 545693006302 active site 545693006303 (T/H)XGH motif; other site 545693006304 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 545693006305 homodimer interface [polypeptide binding]; other site 545693006306 NAD binding pocket [chemical binding]; other site 545693006307 ATP binding pocket [chemical binding]; other site 545693006308 Mg binding site [ion binding]; other site 545693006309 active-site loop [active] 545693006310 hypothetical protein; Provisional; Region: PRK08582 545693006311 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 545693006312 RNA binding site [nucleotide binding]; other site 545693006313 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 545693006314 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 545693006315 Subtilase family; Region: Peptidase_S8; pfam00082 545693006316 catalytic triad [active] 545693006317 putative active site [active] 545693006318 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 545693006319 PA/protease domain interface [polypeptide binding]; other site 545693006320 putative integrin binding motif; other site 545693006321 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 545693006322 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 545693006323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006324 NAD(P) binding site [chemical binding]; other site 545693006325 active site 545693006326 Acylphosphatase; Region: Acylphosphatase; pfam00708 545693006327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693006329 putative substrate translocation pore; other site 545693006330 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 545693006331 Cupin domain; Region: Cupin_2; cl17218 545693006332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693006333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693006334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693006335 EamA-like transporter family; Region: EamA; pfam00892 545693006336 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693006337 EamA-like transporter family; Region: EamA; pfam00892 545693006338 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 545693006339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693006340 ABC transporter; Region: ABC_tran_2; pfam12848 545693006341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693006342 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693006343 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693006344 Spore germination protein; Region: Spore_permease; pfam03845 545693006345 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 545693006346 YtoQ family protein; Region: YtoQ_fam; TIGR03646 545693006347 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693006348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693006349 Walker A/P-loop; other site 545693006350 ATP binding site [chemical binding]; other site 545693006351 Q-loop/lid; other site 545693006352 ABC transporter signature motif; other site 545693006353 Walker B; other site 545693006354 D-loop; other site 545693006355 H-loop/switch region; other site 545693006356 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693006357 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 545693006358 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693006359 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 545693006360 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 545693006361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693006362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693006363 DNA binding site [nucleotide binding] 545693006364 domain linker motif; other site 545693006365 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 545693006366 putative dimerization interface [polypeptide binding]; other site 545693006367 putative ligand binding site [chemical binding]; other site 545693006368 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 545693006369 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 545693006370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693006371 FeS/SAM binding site; other site 545693006372 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 545693006373 DNA topoisomerase III; Provisional; Region: PRK07726 545693006374 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 545693006375 active site 545693006376 putative interdomain interaction site [polypeptide binding]; other site 545693006377 putative metal-binding site [ion binding]; other site 545693006378 putative nucleotide binding site [chemical binding]; other site 545693006379 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693006380 domain I; other site 545693006381 DNA binding groove [nucleotide binding] 545693006382 phosphate binding site [ion binding]; other site 545693006383 domain II; other site 545693006384 domain III; other site 545693006385 nucleotide binding site [chemical binding]; other site 545693006386 catalytic site [active] 545693006387 domain IV; other site 545693006388 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 545693006389 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 545693006390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693006391 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 545693006392 Spore germination protein; Region: Spore_permease; cl17796 545693006393 Spore germination protein; Region: Spore_permease; cl17796 545693006394 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 545693006395 PLD-like domain; Region: PLDc_2; pfam13091 545693006396 putative active site [active] 545693006397 catalytic site [active] 545693006398 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 545693006399 PLD-like domain; Region: PLDc_2; pfam13091 545693006400 putative active site [active] 545693006401 catalytic site [active] 545693006402 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 545693006403 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693006404 Spore germination protein; Region: Spore_permease; pfam03845 545693006405 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 545693006406 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693006407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693006408 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 545693006409 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 545693006410 VanW like protein; Region: VanW; pfam04294 545693006411 Predicted membrane protein [Function unknown]; Region: COG1289 545693006412 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693006413 DNA binding residues [nucleotide binding] 545693006414 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 545693006415 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693006416 Heat induced stress protein YflT; Region: YflT; pfam11181 545693006417 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 545693006418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693006419 ATP binding site [chemical binding]; other site 545693006420 putative Mg++ binding site [ion binding]; other site 545693006421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693006422 nucleotide binding region [chemical binding]; other site 545693006423 ATP-binding site [chemical binding]; other site 545693006424 RQC domain; Region: RQC; pfam09382 545693006425 HRDC domain; Region: HRDC; pfam00570 545693006426 Helix-turn-helix domain; Region: HTH_40; pfam14493 545693006427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006428 PAS domain; Region: PAS_9; pfam13426 545693006429 putative active site [active] 545693006430 heme pocket [chemical binding]; other site 545693006431 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693006432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693006433 Walker A motif; other site 545693006434 ATP binding site [chemical binding]; other site 545693006435 Walker B motif; other site 545693006436 arginine finger; other site 545693006437 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 545693006438 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 545693006439 oligomer interface [polypeptide binding]; other site 545693006440 putative active site [active] 545693006441 Mn binding site [ion binding]; other site 545693006442 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 545693006443 NAD(P) binding site [chemical binding]; other site 545693006444 catalytic residues [active] 545693006445 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693006446 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 545693006447 Na binding site [ion binding]; other site 545693006448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693006449 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 545693006450 ATP binding site [chemical binding]; other site 545693006451 putative Mg++ binding site [ion binding]; other site 545693006452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693006453 nucleotide binding region [chemical binding]; other site 545693006454 ATP-binding site [chemical binding]; other site 545693006455 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 545693006456 putative active site [active] 545693006457 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 545693006458 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 545693006459 DHHA1 domain; Region: DHHA1; pfam02272 545693006460 Predicted membrane protein [Function unknown]; Region: COG1511 545693006461 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693006462 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 545693006463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006464 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 545693006465 pentamer interface [polypeptide binding]; other site 545693006466 dodecaamer interface [polypeptide binding]; other site 545693006467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006468 putative substrate translocation pore; other site 545693006469 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693006470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693006471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693006472 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 545693006473 putative dimerization interface [polypeptide binding]; other site 545693006474 Predicted transcriptional regulators [Transcription]; Region: COG1725 545693006475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006476 DNA-binding site [nucleotide binding]; DNA binding site 545693006477 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693006478 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693006479 Walker A/P-loop; other site 545693006480 ATP binding site [chemical binding]; other site 545693006481 Q-loop/lid; other site 545693006482 ABC transporter signature motif; other site 545693006483 Walker B; other site 545693006484 D-loop; other site 545693006485 H-loop/switch region; other site 545693006486 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693006487 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693006488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693006489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693006490 DNA binding residues [nucleotide binding] 545693006491 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693006492 DNA polymerase IV; Validated; Region: PRK01810 545693006493 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 545693006494 active site 545693006495 DNA binding site [nucleotide binding] 545693006496 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 545693006497 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693006498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693006499 Cold-inducible protein YdjO; Region: YdjO; pfam14169 545693006500 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 545693006501 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 545693006502 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693006503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006504 Coenzyme A binding pocket [chemical binding]; other site 545693006505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693006506 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693006507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693006508 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693006509 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693006510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 545693006511 AAA domain; Region: AAA_11; pfam13086 545693006512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693006513 Walker A motif; other site 545693006514 ATP binding site [chemical binding]; other site 545693006515 AAA domain; Region: AAA_30; pfam13604 545693006516 AAA domain; Region: AAA_12; pfam13087 545693006517 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 545693006518 putative active site [active] 545693006519 catalytic site [active] 545693006520 B12 binding domain; Region: B12-binding_2; pfam02607 545693006521 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 545693006522 B12 binding site [chemical binding]; other site 545693006523 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 545693006524 CheB methylesterase; Region: CheB_methylest; pfam01339 545693006525 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 545693006526 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 545693006527 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 545693006528 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693006529 PAS domain; Region: PAS_10; pfam13596 545693006530 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693006531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006532 putative active site [active] 545693006533 heme pocket [chemical binding]; other site 545693006534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006535 dimer interface [polypeptide binding]; other site 545693006536 phosphorylation site [posttranslational modification] 545693006537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006538 ATP binding site [chemical binding]; other site 545693006539 Mg2+ binding site [ion binding]; other site 545693006540 G-X-G motif; other site 545693006541 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 545693006542 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 545693006543 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 545693006544 gamma-glutamyl kinase; Provisional; Region: PRK13402 545693006545 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 545693006546 nucleotide binding site [chemical binding]; other site 545693006547 homotetrameric interface [polypeptide binding]; other site 545693006548 putative phosphate binding site [ion binding]; other site 545693006549 putative allosteric binding site; other site 545693006550 PUA domain; Region: PUA; pfam01472 545693006551 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 545693006552 putative catalytic cysteine [active] 545693006553 Cold-inducible protein YdjO; Region: YdjO; pfam14169 545693006554 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 545693006555 dimer interface [polypeptide binding]; other site 545693006556 putative metal binding site [ion binding]; other site 545693006557 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 545693006558 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 545693006559 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 545693006560 MMPL family; Region: MMPL; cl14618 545693006561 MMPL family; Region: MMPL; cl14618 545693006562 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 545693006563 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693006564 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 545693006565 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 545693006566 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693006567 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 545693006568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693006569 non-specific DNA binding site [nucleotide binding]; other site 545693006570 salt bridge; other site 545693006571 sequence-specific DNA binding site [nucleotide binding]; other site 545693006572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693006573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693006574 binding surface 545693006575 TPR motif; other site 545693006576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693006577 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 545693006578 oligomeric interface; other site 545693006579 putative active site [active] 545693006580 homodimer interface [polypeptide binding]; other site 545693006581 maltose O-acetyltransferase; Provisional; Region: PRK10092 545693006582 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 545693006583 active site 545693006584 substrate binding site [chemical binding]; other site 545693006585 trimer interface [polypeptide binding]; other site 545693006586 CoA binding site [chemical binding]; other site 545693006587 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 545693006588 Zn binding site [ion binding]; other site 545693006589 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 545693006590 Zn binding site [ion binding]; other site 545693006591 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 545693006592 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693006593 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 545693006594 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 545693006595 Na binding site [ion binding]; other site 545693006596 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693006597 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 545693006598 active site 545693006599 catalytic site [active] 545693006600 substrate binding site [chemical binding]; other site 545693006601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 545693006602 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 545693006603 fumarate hydratase class II, frameshift 545693006604 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 545693006605 active site 545693006606 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 545693006607 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693006608 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693006609 two-component sensor histidine kinase, frameshift 545693006610 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 545693006611 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 545693006612 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693006613 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 545693006614 active site 545693006615 Zn binding site [ion binding]; other site 545693006616 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 545693006617 active site 545693006618 metal binding site [ion binding]; metal-binding site 545693006619 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693006620 active site 545693006621 intersubunit interactions; other site 545693006622 catalytic residue [active] 545693006623 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693006624 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 545693006625 dimer interface [polypeptide binding]; other site 545693006626 FMN binding site [chemical binding]; other site 545693006627 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 545693006628 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 545693006629 classical (c) SDRs; Region: SDR_c; cd05233 545693006630 NAD(P) binding site [chemical binding]; other site 545693006631 active site 545693006632 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693006633 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 545693006634 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693006635 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 545693006636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006637 NAD(P) binding site [chemical binding]; other site 545693006638 active site 545693006639 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 545693006640 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 545693006641 metal binding site [ion binding]; metal-binding site 545693006642 dimer interface [polypeptide binding]; other site 545693006643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693006644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006645 Coenzyme A binding pocket [chemical binding]; other site 545693006646 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693006647 putative DNA binding site [nucleotide binding]; other site 545693006648 dimerization interface [polypeptide binding]; other site 545693006649 putative Zn2+ binding site [ion binding]; other site 545693006650 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 545693006651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 545693006652 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 545693006653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 545693006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693006655 S-adenosylmethionine binding site [chemical binding]; other site 545693006656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693006657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693006658 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 545693006659 putative dimerization interface [polypeptide binding]; other site 545693006660 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 545693006661 diaminopimelate decarboxylase; Region: lysA; TIGR01048 545693006662 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 545693006663 active site 545693006664 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693006665 substrate binding site [chemical binding]; other site 545693006666 catalytic residues [active] 545693006667 dimer interface [polypeptide binding]; other site 545693006668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693006669 FAD dependent oxidoreductase; Region: DAO; pfam01266 545693006670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693006671 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 545693006672 PAS domain S-box; Region: sensory_box; TIGR00229 545693006673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006674 putative active site [active] 545693006675 heme pocket [chemical binding]; other site 545693006676 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693006677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006678 putative active site [active] 545693006679 heme pocket [chemical binding]; other site 545693006680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006681 dimer interface [polypeptide binding]; other site 545693006682 phosphorylation site [posttranslational modification] 545693006683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006684 ATP binding site [chemical binding]; other site 545693006685 Mg2+ binding site [ion binding]; other site 545693006686 G-X-G motif; other site 545693006687 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 545693006688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693006689 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 545693006690 FAD binding site [chemical binding]; other site 545693006691 substrate binding site [chemical binding]; other site 545693006692 catalytic base [active] 545693006693 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 545693006694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006695 NAD(P) binding site [chemical binding]; other site 545693006696 active site 545693006697 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 545693006698 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 545693006699 acyl-activating enzyme (AAE) consensus motif; other site 545693006700 putative AMP binding site [chemical binding]; other site 545693006701 putative active site [active] 545693006702 putative CoA binding site [chemical binding]; other site 545693006703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693006704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693006705 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 545693006706 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 545693006707 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 545693006708 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693006709 enoyl-CoA hydratase; Provisional; Region: PRK06688 545693006710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693006711 substrate binding site [chemical binding]; other site 545693006712 oxyanion hole (OAH) forming residues; other site 545693006713 trimer interface [polypeptide binding]; other site 545693006714 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693006715 active site 545693006716 Phosphotransferase enzyme family; Region: APH; pfam01636 545693006717 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 545693006718 putative active site [active] 545693006719 putative substrate binding site [chemical binding]; other site 545693006720 ATP binding site [chemical binding]; other site 545693006721 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 545693006722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693006723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693006724 active site 545693006725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693006726 classical (c) SDRs; Region: SDR_c; cd05233 545693006727 NAD(P) binding site [chemical binding]; other site 545693006728 active site 545693006729 enoyl-CoA hydratase; Provisional; Region: PRK06688 545693006730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693006731 substrate binding site [chemical binding]; other site 545693006732 oxyanion hole (OAH) forming residues; other site 545693006733 trimer interface [polypeptide binding]; other site 545693006734 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693006735 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 545693006736 NADP binding site [chemical binding]; other site 545693006737 dimer interface [polypeptide binding]; other site 545693006738 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 545693006739 active site 545693006740 multimer interface [polypeptide binding]; other site 545693006741 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 545693006742 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 545693006743 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 545693006744 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 545693006745 putative acyltransferase; Provisional; Region: PRK05790 545693006746 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693006747 dimer interface [polypeptide binding]; other site 545693006748 active site 545693006749 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693006750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693006751 inhibitor-cofactor binding pocket; inhibition site 545693006752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006753 catalytic residue [active] 545693006754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693006755 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693006756 inhibitor-cofactor binding pocket; inhibition site 545693006757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006758 catalytic residue [active] 545693006759 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 545693006760 NAD(P) binding site [chemical binding]; other site 545693006761 catalytic residues [active] 545693006762 Uncharacterized conserved protein [Function unknown]; Region: COG5476 545693006763 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 545693006764 MlrC C-terminus; Region: MlrC_C; pfam07171 545693006765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006766 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693006767 Coenzyme A binding pocket [chemical binding]; other site 545693006768 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 545693006769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693006770 FeS/SAM binding site; other site 545693006771 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 545693006772 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 545693006773 toxin interface [polypeptide binding]; other site 545693006774 Zn binding site [ion binding]; other site 545693006775 lysine transporter; Provisional; Region: PRK10836 545693006776 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693006777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693006778 Bacterial PH domain; Region: bPH_4; cl19751 545693006779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006781 Coenzyme A binding pocket [chemical binding]; other site 545693006782 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 545693006783 dimer interface [polypeptide binding]; other site 545693006784 active site 545693006785 metal binding site [ion binding]; metal-binding site 545693006786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006787 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 545693006788 putative substrate translocation pore; other site 545693006789 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 545693006790 Prephenate dehydratase; Region: PDT; pfam00800 545693006791 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 545693006792 EamA-like transporter family; Region: EamA; pfam00892 545693006793 EamA-like transporter family; Region: EamA; pfam00892 545693006794 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 545693006795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693006796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006797 homodimer interface [polypeptide binding]; other site 545693006798 catalytic residue [active] 545693006799 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693006800 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 545693006801 active site 545693006802 dimer interface [polypeptide binding]; other site 545693006803 histidyl-tRNA synthetase; Region: hisS; TIGR00442 545693006804 motif 1; other site 545693006805 motif 2; other site 545693006806 motif 3; other site 545693006807 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 545693006808 anticodon binding site; other site 545693006809 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 545693006810 amino acid transporter; Region: 2A0306; TIGR00909 545693006811 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693006812 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 545693006813 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693006814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006815 putative substrate translocation pore; other site 545693006816 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693006817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693006818 putative Zn2+ binding site [ion binding]; other site 545693006819 putative DNA binding site [nucleotide binding]; other site 545693006820 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 545693006821 MMPL family; Region: MMPL; pfam03176 545693006822 HemX; Region: HemX; cl19375 545693006823 MMPL family; Region: MMPL; cl14618 545693006824 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693006825 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 545693006826 Walker A/P-loop; other site 545693006827 ATP binding site [chemical binding]; other site 545693006828 Q-loop/lid; other site 545693006829 ABC transporter signature motif; other site 545693006830 Walker B; other site 545693006831 D-loop; other site 545693006832 H-loop/switch region; other site 545693006833 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 545693006834 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 545693006835 putative active site [active] 545693006836 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 545693006837 dimer interface [polypeptide binding]; other site 545693006838 active site 545693006839 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693006840 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 545693006841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 545693006842 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693006843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693006844 dimer interface [polypeptide binding]; other site 545693006845 conserved gate region; other site 545693006846 putative PBP binding loops; other site 545693006847 ABC-ATPase subunit interface; other site 545693006848 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693006849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693006850 dimer interface [polypeptide binding]; other site 545693006851 conserved gate region; other site 545693006852 putative PBP binding loops; other site 545693006853 ABC-ATPase subunit interface; other site 545693006854 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 545693006855 substrate binding site [chemical binding]; other site 545693006856 ATP binding site [chemical binding]; other site 545693006857 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 545693006858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006859 DNA-binding site [nucleotide binding]; DNA binding site 545693006860 UTRA domain; Region: UTRA; pfam07702 545693006861 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693006862 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 545693006863 putative hydrophobic ligand binding site [chemical binding]; other site 545693006864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693006865 dimerization interface [polypeptide binding]; other site 545693006866 putative DNA binding site [nucleotide binding]; other site 545693006867 putative Zn2+ binding site [ion binding]; other site 545693006868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693006869 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693006870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693006871 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 545693006872 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 545693006873 active site residue [active] 545693006874 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 545693006875 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 545693006876 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 545693006877 apolar tunnel; other site 545693006878 heme binding site [chemical binding]; other site 545693006879 dimerization interface [polypeptide binding]; other site 545693006880 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 545693006881 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 545693006882 Protein of unknown function (DUF817); Region: DUF817; pfam05675 545693006883 heat shock protein 90; Provisional; Region: PRK05218 545693006884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006885 ATP binding site [chemical binding]; other site 545693006886 Mg2+ binding site [ion binding]; other site 545693006887 G-X-G motif; other site 545693006888 Hsp90 protein; Region: HSP90; pfam00183 545693006889 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 545693006890 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 545693006891 putative ligand binding site [chemical binding]; other site 545693006892 putative NAD binding site [chemical binding]; other site 545693006893 putative catalytic site [active] 545693006894 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 545693006895 L-serine binding site [chemical binding]; other site 545693006896 ACT domain interface; other site 545693006897 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 545693006898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693006899 Zn2+ binding site [ion binding]; other site 545693006900 Mg2+ binding site [ion binding]; other site 545693006901 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 545693006902 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 545693006903 active site 545693006904 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693006905 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693006906 EamA-like transporter family; Region: EamA; pfam00892 545693006907 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693006908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006909 DNA-binding site [nucleotide binding]; DNA binding site 545693006910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693006911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006912 homodimer interface [polypeptide binding]; other site 545693006913 catalytic residue [active] 545693006914 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 545693006915 ChaB; Region: ChaB; pfam06150 545693006916 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 545693006917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693006918 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 545693006919 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 545693006920 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 545693006921 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 545693006922 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 545693006923 NAD(P) binding site [chemical binding]; other site 545693006924 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 545693006925 putative FMN binding site [chemical binding]; other site 545693006926 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693006927 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 545693006928 Walker A/P-loop; other site 545693006929 ATP binding site [chemical binding]; other site 545693006930 Q-loop/lid; other site 545693006931 ABC transporter signature motif; other site 545693006932 Walker B; other site 545693006933 D-loop; other site 545693006934 H-loop/switch region; other site 545693006935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693006936 FtsX-like permease family; Region: FtsX; pfam02687 545693006937 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693006938 FtsX-like permease family; Region: FtsX; pfam02687 545693006939 transglutaminase; Provisional; Region: tgl; PRK03187 545693006940 DinB superfamily; Region: DinB_2; pfam12867 545693006941 Domain of unknown function (DUF378); Region: DUF378; cl00943 545693006942 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 545693006943 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 545693006944 cobalamin binding residues [chemical binding]; other site 545693006945 putative BtuC binding residues; other site 545693006946 dimer interface [polypeptide binding]; other site 545693006947 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 545693006948 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 545693006949 putative active site [active] 545693006950 putative CoA binding site [chemical binding]; other site 545693006951 nudix motif; other site 545693006952 metal binding site [ion binding]; metal-binding site 545693006953 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 545693006954 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 545693006955 NAD(P) binding site [chemical binding]; other site 545693006956 putative active site [active] 545693006957 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 545693006958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 545693006959 acyl-activating enzyme (AAE) consensus motif; other site 545693006960 AMP binding site [chemical binding]; other site 545693006961 active site 545693006962 CoA binding site [chemical binding]; other site 545693006963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693006964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693006965 dimerization interface [polypeptide binding]; other site 545693006966 putative DNA binding site [nucleotide binding]; other site 545693006967 putative Zn2+ binding site [ion binding]; other site 545693006968 VanW like protein; Region: VanW; pfam04294 545693006969 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 545693006970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 545693006971 acyl-activating enzyme (AAE) consensus motif; other site 545693006972 AMP binding site [chemical binding]; other site 545693006973 active site 545693006974 CoA binding site [chemical binding]; other site 545693006975 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 545693006976 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 545693006977 active site 545693006978 catalytic site [active] 545693006979 substrate binding site [chemical binding]; other site 545693006980 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 545693006981 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 545693006982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006983 catalytic residue [active] 545693006984 Tubby C 2; Region: Tub_2; cl02043 545693006985 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 545693006986 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 545693006987 G1 box; other site 545693006988 GTP/Mg2+ binding site [chemical binding]; other site 545693006989 G2 box; other site 545693006990 Switch I region; other site 545693006991 G3 box; other site 545693006992 Switch II region; other site 545693006993 G4 box; other site 545693006994 G5 box; other site 545693006995 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 545693006996 Elongation Factor G, domain II; Region: EFG_II; pfam14492 545693006997 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 545693006998 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 545693006999 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 545693007000 Uncharacterized conserved protein [Function unknown]; Region: COG5609 545693007001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693007002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007003 putative substrate translocation pore; other site 545693007004 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 545693007005 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007006 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 545693007007 Cache domain; Region: Cache_1; pfam02743 545693007008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693007009 dimerization interface [polypeptide binding]; other site 545693007010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 545693007011 putative CheW interface [polypeptide binding]; other site 545693007012 dimer interface [polypeptide binding]; other site 545693007013 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 545693007014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 545693007015 dimer interface [polypeptide binding]; other site 545693007016 putative CheW interface [polypeptide binding]; other site 545693007017 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 545693007018 active site 545693007019 metal binding site [ion binding]; metal-binding site 545693007020 homotetramer interface [polypeptide binding]; other site 545693007021 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 545693007022 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 545693007023 putative active site [active] 545693007024 putative metal binding site [ion binding]; other site 545693007025 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 545693007026 active site 545693007027 SUMO-1 interface [polypeptide binding]; other site 545693007028 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 545693007029 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693007030 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693007031 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693007032 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 545693007033 active site 545693007034 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693007035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693007036 putative DNA binding site [nucleotide binding]; other site 545693007037 putative Zn2+ binding site [ion binding]; other site 545693007038 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693007039 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 545693007040 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693007041 ATP-grasp domain; Region: ATP-grasp_4; cl17255 545693007042 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 545693007043 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 545693007044 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693007045 carboxyltransferase (CT) interaction site; other site 545693007046 biotinylation site [posttranslational modification]; other site 545693007047 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 545693007048 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 545693007049 hypothetical protein; Provisional; Region: PRK05463 545693007050 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 545693007051 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 545693007052 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 545693007053 putative active site [active] 545693007054 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 545693007055 Ca binding site [ion binding]; other site 545693007056 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 545693007057 active site 545693007058 catalytic site [active] 545693007059 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 545693007060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007061 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693007062 Coenzyme A binding pocket [chemical binding]; other site 545693007063 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 545693007064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 545693007065 acyl-activating enzyme (AAE) consensus motif; other site 545693007066 AMP binding site [chemical binding]; other site 545693007067 active site 545693007068 CoA binding site [chemical binding]; other site 545693007069 BioY family; Region: BioY; pfam02632 545693007070 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 545693007071 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693007072 dimer interface [polypeptide binding]; other site 545693007073 active site 545693007074 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693007075 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 545693007076 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 545693007077 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 545693007078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693007079 ATP binding site [chemical binding]; other site 545693007080 putative Mg++ binding site [ion binding]; other site 545693007081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693007082 nucleotide binding region [chemical binding]; other site 545693007083 ATP-binding site [chemical binding]; other site 545693007084 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693007085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007086 putative substrate translocation pore; other site 545693007087 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 545693007088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693007089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693007090 active site 545693007091 phosphorylation site [posttranslational modification] 545693007092 intermolecular recognition site; other site 545693007093 dimerization interface [polypeptide binding]; other site 545693007094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693007095 DNA binding residues [nucleotide binding] 545693007096 dimerization interface [polypeptide binding]; other site 545693007097 GAF domain; Region: GAF_2; pfam13185 545693007098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693007099 Histidine kinase; Region: HisKA_3; pfam07730 545693007100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693007101 ATP binding site [chemical binding]; other site 545693007102 Mg2+ binding site [ion binding]; other site 545693007103 G-X-G motif; other site 545693007104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693007105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693007106 non-specific DNA binding site [nucleotide binding]; other site 545693007107 salt bridge; other site 545693007108 sequence-specific DNA binding site [nucleotide binding]; other site 545693007109 Cupin domain; Region: Cupin_2; pfam07883 545693007110 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 545693007111 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 545693007112 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 545693007113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 545693007114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007115 Coenzyme A binding pocket [chemical binding]; other site 545693007116 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 545693007117 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 545693007118 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 545693007119 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 545693007120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 545693007121 DHHA2 domain; Region: DHHA2; pfam02833 545693007122 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 545693007123 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 545693007124 homodimer interface [polypeptide binding]; other site 545693007125 substrate-cofactor binding pocket; other site 545693007126 catalytic residue [active] 545693007127 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 545693007128 putative acyl-acceptor binding pocket; other site 545693007129 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693007130 xanthine permease; Region: pbuX; TIGR03173 545693007131 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 545693007132 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 545693007133 active site 545693007134 homotetramer interface [polypeptide binding]; other site 545693007135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693007136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007137 Coenzyme A binding pocket [chemical binding]; other site 545693007138 manganese transport protein MntH; Reviewed; Region: PRK00701 545693007139 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 545693007140 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 545693007141 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 545693007142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693007143 motif II; other site 545693007144 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693007145 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693007146 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 545693007147 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 545693007148 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 545693007149 active site 545693007150 catalytic residues [active] 545693007151 DNA binding site [nucleotide binding] 545693007152 Int/Topo IB signature motif; other site 545693007153 ethanolamine permease; Region: 2A0305; TIGR00908 545693007154 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693007155 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 545693007156 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 545693007157 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 545693007158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693007159 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 545693007160 lysine transporter; Provisional; Region: PRK10836 545693007161 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693007162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693007163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007164 Coenzyme A binding pocket [chemical binding]; other site 545693007165 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693007166 catalytic triad [active] 545693007167 conserved cis-peptide bond; other site 545693007168 Cupin domain; Region: Cupin_2; cl17218 545693007169 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 545693007170 LysE type translocator; Region: LysE; cl00565 545693007171 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693007172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693007173 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 545693007174 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 545693007175 CAP-like domain; other site 545693007176 active site 545693007177 primary dimer interface [polypeptide binding]; other site 545693007178 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693007179 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693007180 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693007181 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 545693007182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693007183 ATP binding site [chemical binding]; other site 545693007184 Mg2+ binding site [ion binding]; other site 545693007185 G-X-G motif; other site 545693007186 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 545693007187 anchoring element; other site 545693007188 dimer interface [polypeptide binding]; other site 545693007189 ATP binding site [chemical binding]; other site 545693007190 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 545693007191 active site 545693007192 metal binding site [ion binding]; metal-binding site 545693007193 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 545693007194 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 545693007195 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 545693007196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 545693007197 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693007198 active site 545693007199 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 545693007200 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 545693007201 putative active site [active] 545693007202 putative catalytic site [active] 545693007203 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 545693007204 PLD-like domain; Region: PLDc_2; pfam13091 545693007205 catalytic site [active] 545693007206 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 545693007207 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 545693007208 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 545693007209 catalytic residues [active] 545693007210 aconitate hydratase; Validated; Region: PRK09277 545693007211 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 545693007212 substrate binding site [chemical binding]; other site 545693007213 ligand binding site [chemical binding]; other site 545693007214 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 545693007215 substrate binding site [chemical binding]; other site 545693007216 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 545693007217 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 545693007218 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693007219 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693007220 putative dimer interface [polypeptide binding]; other site 545693007221 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 545693007222 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 545693007223 DNA binding site [nucleotide binding] 545693007224 heterodimer interface [polypeptide binding]; other site 545693007225 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 545693007226 Protein of unknown function (DUF524); Region: DUF524; pfam04411 545693007227 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 545693007228 AAA domain; Region: AAA_22; pfam13401 545693007229 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 545693007230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 545693007231 catalytic loop [active] 545693007232 iron binding site [ion binding]; other site 545693007233 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 545693007234 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 545693007235 FAD binding domain; Region: FAD_binding_4; cl19922 545693007236 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 545693007237 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 545693007238 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 545693007239 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 545693007240 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 545693007241 Ligand binding site; other site 545693007242 metal-binding site 545693007243 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 545693007244 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 545693007245 XdhC Rossmann domain; Region: XdhC_C; pfam13478 545693007246 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693007247 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693007248 putative dimer interface [polypeptide binding]; other site 545693007249 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693007250 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 545693007251 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 545693007252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 545693007253 hypothetical protein; Provisional; Region: PRK09272 545693007254 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693007255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693007256 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693007257 Predicted transcriptional regulators [Transcription]; Region: COG1378 545693007258 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 545693007259 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 545693007260 C-terminal domain interface [polypeptide binding]; other site 545693007261 sugar binding site [chemical binding]; other site 545693007262 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693007263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007264 putative substrate translocation pore; other site 545693007265 Uncharacterized conserved protein [Function unknown]; Region: COG1683 545693007266 Asp23 family; Region: Asp23; pfam03780 545693007267 Asp23 family; Region: Asp23; pfam03780 545693007268 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 545693007269 Domain of unknown function (DUF202); Region: DUF202; pfam02656 545693007270 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 545693007271 drug efflux system protein MdtG; Provisional; Region: PRK09874 545693007272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007273 putative substrate translocation pore; other site 545693007274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693007276 putative substrate translocation pore; other site 545693007277 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693007278 DNA binding residues [nucleotide binding] 545693007279 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 545693007280 active site clefts [active] 545693007281 zinc binding site [ion binding]; other site 545693007282 dimer interface [polypeptide binding]; other site 545693007283 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 545693007284 putative transporter; Provisional; Region: PRK11660 545693007285 Sulfate transporter family; Region: Sulfate_transp; pfam00916 545693007286 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 545693007287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693007288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693007289 active site 545693007290 phosphorylation site [posttranslational modification] 545693007291 intermolecular recognition site; other site 545693007292 dimerization interface [polypeptide binding]; other site 545693007293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693007294 DNA binding site [nucleotide binding] 545693007295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693007296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693007297 dimerization interface [polypeptide binding]; other site 545693007298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693007299 dimer interface [polypeptide binding]; other site 545693007300 phosphorylation site [posttranslational modification] 545693007301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693007302 ATP binding site [chemical binding]; other site 545693007303 Mg2+ binding site [ion binding]; other site 545693007304 G-X-G motif; other site 545693007305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007306 Coenzyme A binding pocket [chemical binding]; other site 545693007307 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693007308 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 545693007309 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693007310 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693007311 RQC domain; Region: RQC; cl09632 545693007312 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 545693007313 stage II sporulation protein P; Region: spore_II_P; TIGR02867 545693007314 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 545693007315 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 545693007316 homodimer interface [polypeptide binding]; other site 545693007317 Walker A motif; other site 545693007318 ATP binding site [chemical binding]; other site 545693007319 hydroxycobalamin binding site [chemical binding]; other site 545693007320 Walker B motif; other site 545693007321 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 545693007322 putative FMN binding site [chemical binding]; other site 545693007323 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 545693007324 active site 545693007325 SAM binding site [chemical binding]; other site 545693007326 homodimer interface [polypeptide binding]; other site 545693007327 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 545693007328 AAA domain; Region: AAA_30; pfam13604 545693007329 Protein of unknown function (DUF1611); Region: DUF1611; cl19508 545693007330 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 545693007331 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 545693007332 catalytic triad [active] 545693007333 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 545693007334 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 545693007335 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 545693007336 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 545693007337 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 545693007338 active site 545693007339 SAM binding site [chemical binding]; other site 545693007340 homodimer interface [polypeptide binding]; other site 545693007341 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 545693007342 active site 545693007343 SAM binding site [chemical binding]; other site 545693007344 homodimer interface [polypeptide binding]; other site 545693007345 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 545693007346 active site 545693007347 putative homodimer interface [polypeptide binding]; other site 545693007348 SAM binding site [chemical binding]; other site 545693007349 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 545693007350 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 545693007351 Precorrin-8X methylmutase; Region: CbiC; pfam02570 545693007352 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 545693007353 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 545693007354 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 545693007355 putative active site [active] 545693007356 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 545693007357 putative active site [active] 545693007358 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 545693007359 active site 545693007360 SAM binding site [chemical binding]; other site 545693007361 homodimer interface [polypeptide binding]; other site 545693007362 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 545693007363 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 545693007364 dimer interface [polypeptide binding]; other site 545693007365 [2Fe-2S] cluster binding site [ion binding]; other site 545693007366 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 545693007367 putative oligomer interface [polypeptide binding]; other site 545693007368 putative active site [active] 545693007369 metal binding site [ion binding]; metal-binding site 545693007370 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693007371 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 545693007372 IDEAL domain; Region: IDEAL; cl07452 545693007373 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 545693007374 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 545693007375 Uncharacterized conserved protein [Function unknown]; Region: COG2427 545693007376 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 545693007377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693007378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693007379 Membrane transport protein; Region: Mem_trans; cl09117 545693007380 malate dehydrogenase; Provisional; Region: PRK13529 545693007381 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693007382 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 545693007383 NAD(P) binding site [chemical binding]; other site 545693007384 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693007385 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 545693007386 putative metal binding site [ion binding]; other site 545693007387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007388 D-galactonate transporter; Region: 2A0114; TIGR00893 545693007389 putative substrate translocation pore; other site 545693007390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 545693007391 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693007392 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693007393 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 545693007394 UbiD family decarboxylase; Region: TIGR00148 545693007395 aromatic acid decarboxylase; Validated; Region: PRK05920 545693007396 archaeoflavoprotein AfpA; Region: archaeo_AfpA; TIGR02699 545693007397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693007398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693007399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693007400 dimerization interface [polypeptide binding]; other site 545693007401 Membrane transport protein; Region: Mem_trans; cl09117 545693007402 Uncharacterized conserved protein [Function unknown]; Region: COG3339 545693007403 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693007404 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 545693007405 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 545693007406 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693007407 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 545693007408 Cysteine-rich domain; Region: CCG; pfam02754 545693007409 Cysteine-rich domain; Region: CCG; pfam02754 545693007410 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007411 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 545693007412 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 545693007413 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693007414 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 545693007415 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693007416 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 545693007417 intracellular protease, PfpI family; Region: PfpI; TIGR01382 545693007418 conserved cys residue [active] 545693007419 IDEAL domain; Region: IDEAL; cl07452 545693007420 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 545693007421 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 545693007422 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 545693007423 putative active site [active] 545693007424 metal binding site [ion binding]; metal-binding site 545693007425 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693007426 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 545693007427 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693007428 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 545693007429 ABC-2 type transporter; Region: ABC2_membrane; cl17235 545693007430 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693007431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693007432 Walker A/P-loop; other site 545693007433 ATP binding site [chemical binding]; other site 545693007434 Q-loop/lid; other site 545693007435 ABC transporter signature motif; other site 545693007436 Walker B; other site 545693007437 D-loop; other site 545693007438 H-loop/switch region; other site 545693007439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 545693007440 Histidine kinase; Region: HisKA_3; pfam07730 545693007441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693007442 ATP binding site [chemical binding]; other site 545693007443 Mg2+ binding site [ion binding]; other site 545693007444 G-X-G motif; other site 545693007445 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693007446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693007447 active site 545693007448 phosphorylation site [posttranslational modification] 545693007449 intermolecular recognition site; other site 545693007450 dimerization interface [polypeptide binding]; other site 545693007451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693007452 DNA binding residues [nucleotide binding] 545693007453 dimerization interface [polypeptide binding]; other site 545693007454 allantoate amidohydrolase; Reviewed; Region: PRK09290 545693007455 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 545693007456 active site 545693007457 metal binding site [ion binding]; metal-binding site 545693007458 dimer interface [polypeptide binding]; other site 545693007459 Predicted integral membrane protein [Function unknown]; Region: COG5542 545693007460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007461 Coenzyme A binding pocket [chemical binding]; other site 545693007462 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 545693007463 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 545693007464 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 545693007465 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 545693007466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 545693007467 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 545693007468 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 545693007469 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 545693007470 Active_site [active] 545693007471 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693007472 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 545693007473 active site 545693007474 catalytic site [active] 545693007475 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 545693007476 active site 545693007477 catalytic triad [active] 545693007478 dimer interface [polypeptide binding]; other site 545693007479 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693007480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693007481 Walker A motif; other site 545693007482 ATP binding site [chemical binding]; other site 545693007483 Walker B motif; other site 545693007484 arginine finger; other site 545693007485 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 545693007486 active site 545693007487 catalytic triad [active] 545693007488 dimer interface [polypeptide binding]; other site 545693007489 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693007490 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693007491 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693007492 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 545693007493 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693007494 Protein of unknown function, DUF600; Region: DUF600; cl04640 545693007495 Protein of unknown function, DUF600; Region: DUF600; cl04640 545693007496 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 545693007497 Uncharacterized conserved protein [Function unknown]; Region: COG5620 545693007498 GAD-like domain; Region: GAD-like; pfam08887 545693007499 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 545693007500 Putative toxin 43; Region: Toxin_43; pfam15604 545693007501 Uncharacterized conserved protein [Function unknown]; Region: COG5444 545693007502 LXG domain of WXG superfamily; Region: LXG; pfam04740 545693007503 Pre-toxin TG; Region: PT-TG; pfam14449 545693007504 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 545693007505 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 545693007506 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 545693007507 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 545693007508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693007509 E3 interaction surface; other site 545693007510 lipoyl attachment site [posttranslational modification]; other site 545693007511 HlyD family secretion protein; Region: HlyD_3; pfam13437 545693007512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007513 putative substrate translocation pore; other site 545693007514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693007515 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693007516 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693007517 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 545693007518 active site 545693007519 putative catalytic site [active] 545693007520 DNA binding site [nucleotide binding] 545693007521 putative phosphate binding site [ion binding]; other site 545693007522 metal binding site A [ion binding]; metal-binding site 545693007523 AP binding site [nucleotide binding]; other site 545693007524 metal binding site B [ion binding]; metal-binding site 545693007525 Erythromycin esterase; Region: Erythro_esteras; pfam05139 545693007526 Domain of unknown function (DUF336); Region: DUF336; cl01249 545693007527 putative oxidoreductase; Provisional; Region: PRK11579 545693007528 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693007529 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693007530 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693007531 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 545693007532 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 545693007533 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 545693007534 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 545693007535 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 545693007536 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 545693007537 putative metal binding site [ion binding]; other site 545693007538 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 545693007539 putative metal binding site [ion binding]; other site 545693007540 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 545693007541 putative metal binding site [ion binding]; other site 545693007542 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 545693007543 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 545693007544 active site 545693007545 metal binding site [ion binding]; metal-binding site 545693007546 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 545693007547 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 545693007548 putative active site [active] 545693007549 putative metal binding site [ion binding]; other site 545693007550 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 545693007551 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 545693007552 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693007553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693007554 Walker A/P-loop; other site 545693007555 ATP binding site [chemical binding]; other site 545693007556 Q-loop/lid; other site 545693007557 ABC transporter signature motif; other site 545693007558 Walker B; other site 545693007559 D-loop; other site 545693007560 H-loop/switch region; other site 545693007561 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 545693007562 active site 545693007563 catalytic triad [active] 545693007564 oxyanion hole [active] 545693007565 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 545693007566 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693007567 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 545693007568 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693007569 DNA-binding site [nucleotide binding]; DNA binding site 545693007570 RNA-binding motif; other site 545693007571 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693007572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693007573 DNA-binding site [nucleotide binding]; DNA binding site 545693007574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693007575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693007576 homodimer interface [polypeptide binding]; other site 545693007577 catalytic residue [active] 545693007578 pyruvate oxidase; Provisional; Region: PRK08611 545693007579 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 545693007580 PYR/PP interface [polypeptide binding]; other site 545693007581 dimer interface [polypeptide binding]; other site 545693007582 tetramer interface [polypeptide binding]; other site 545693007583 TPP binding site [chemical binding]; other site 545693007584 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693007585 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 545693007586 TPP-binding site [chemical binding]; other site 545693007587 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693007588 DNA-binding site [nucleotide binding]; DNA binding site 545693007589 RNA-binding motif; other site 545693007590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693007591 classical (c) SDRs; Region: SDR_c; cd05233 545693007592 NAD(P) binding site [chemical binding]; other site 545693007593 active site 545693007594 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 545693007595 classical (c) SDRs; Region: SDR_c; cd05233 545693007596 NAD(P) binding site [chemical binding]; other site 545693007597 active site 545693007598 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693007599 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 545693007600 NADP binding site [chemical binding]; other site 545693007601 dimer interface [polypeptide binding]; other site 545693007602 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 545693007603 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 545693007604 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 545693007605 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693007606 LytTr DNA-binding domain; Region: LytTR; pfam04397 545693007607 Predicted membrane protein [Function unknown]; Region: COG2323 545693007608 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693007609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007610 putative substrate translocation pore; other site 545693007611 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693007612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 545693007613 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 545693007614 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 545693007615 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 545693007616 Cupin; Region: Cupin_1; smart00835 545693007617 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693007618 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693007619 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693007620 active site 545693007621 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 545693007622 NADPH bind site [chemical binding]; other site 545693007623 putative FMN binding site [chemical binding]; other site 545693007624 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 545693007625 putative FMN binding site [chemical binding]; other site 545693007626 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 545693007627 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 545693007628 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 545693007629 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 545693007630 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 545693007631 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 545693007632 active site 545693007633 HIGH motif; other site 545693007634 KMSKS motif; other site 545693007635 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 545693007636 tRNA binding surface [nucleotide binding]; other site 545693007637 anticodon binding site; other site 545693007638 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 545693007639 GIY-YIG motif/motif A; other site 545693007640 putative active site [active] 545693007641 putative metal binding site [ion binding]; other site 545693007642 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 545693007643 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 545693007644 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 545693007645 active site 545693007646 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 545693007647 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 545693007648 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 545693007649 active site 545693007650 nucleophile elbow; other site 545693007651 Mitotic checkpoint protein; Region: MAD; pfam05557 545693007652 Phosphotransferase enzyme family; Region: APH; pfam01636 545693007653 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 545693007654 active site 545693007655 substrate binding site [chemical binding]; other site 545693007656 ATP binding site [chemical binding]; other site 545693007657 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 545693007658 DinB family; Region: DinB; cl17821 545693007659 malate:quinone oxidoreductase; Validated; Region: PRK05257 545693007660 Predicted dehydrogenase [General function prediction only]; Region: COG0579 545693007661 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 545693007662 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 545693007663 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 545693007664 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 545693007665 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 545693007666 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693007667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693007668 ABC transporter; Region: ABC_tran_2; pfam12848 545693007669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 545693007670 alpha-galactosidase; Provisional; Region: PRK15076 545693007671 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 545693007672 NAD binding site [chemical binding]; other site 545693007673 sugar binding site [chemical binding]; other site 545693007674 divalent metal binding site [ion binding]; other site 545693007675 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693007676 dimer interface [polypeptide binding]; other site 545693007677 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693007678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007679 dimer interface [polypeptide binding]; other site 545693007680 conserved gate region; other site 545693007681 putative PBP binding loops; other site 545693007682 ABC-ATPase subunit interface; other site 545693007683 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693007684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007685 dimer interface [polypeptide binding]; other site 545693007686 conserved gate region; other site 545693007687 putative PBP binding loops; other site 545693007688 ABC-ATPase subunit interface; other site 545693007689 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693007690 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 545693007691 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 545693007692 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693007693 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693007694 DNA binding site [nucleotide binding] 545693007695 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 545693007696 putative dimerization interface [polypeptide binding]; other site 545693007697 putative ligand binding site [chemical binding]; other site 545693007698 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 545693007699 active site 545693007700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007701 Coenzyme A binding pocket [chemical binding]; other site 545693007702 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 545693007703 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 545693007704 fructuronate transporter; Provisional; Region: PRK10034; cl15264 545693007705 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 545693007706 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693007707 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 545693007708 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693007709 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 545693007710 active site 545693007711 NAD binding site [chemical binding]; other site 545693007712 metal binding site [ion binding]; metal-binding site 545693007713 Protein of unknown function (DUF805); Region: DUF805; pfam05656 545693007714 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693007715 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693007716 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693007717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693007718 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 545693007719 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 545693007720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693007721 substrate binding pocket [chemical binding]; other site 545693007722 membrane-bound complex binding site; other site 545693007723 hinge residues; other site 545693007724 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 545693007725 Protein of unknown function (DUF805); Region: DUF805; pfam05656 545693007726 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 545693007727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007728 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693007729 putative substrate translocation pore; other site 545693007730 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 545693007731 hexamer interface [polypeptide binding]; other site 545693007732 transport channel [chemical binding]; other site 545693007733 constriction site 1 [chemical binding]; other site 545693007734 constriction site 2 [chemical binding]; other site 545693007735 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 545693007736 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 545693007737 Nucleoside recognition; Region: Gate; pfam07670 545693007738 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 545693007739 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 545693007740 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 545693007741 active site 545693007742 catalytic motif [active] 545693007743 Zn binding site [ion binding]; other site 545693007744 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 545693007745 intersubunit interface [polypeptide binding]; other site 545693007746 active site 545693007747 catalytic residue [active] 545693007748 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 545693007749 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 545693007750 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 545693007751 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 545693007752 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 545693007753 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 545693007754 DNA binding residues [nucleotide binding] 545693007755 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 545693007756 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 545693007757 metal binding site [ion binding]; metal-binding site 545693007758 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 545693007759 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 545693007760 active site 545693007761 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 545693007762 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 545693007763 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693007764 Peptidase family M48; Region: Peptidase_M48; cl12018 545693007765 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693007766 hypothetical protein; Provisional; Region: PRK02237 545693007767 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693007768 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 545693007769 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693007770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007771 dimer interface [polypeptide binding]; other site 545693007772 conserved gate region; other site 545693007773 putative PBP binding loops; other site 545693007774 ABC-ATPase subunit interface; other site 545693007775 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693007776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007777 dimer interface [polypeptide binding]; other site 545693007778 conserved gate region; other site 545693007779 putative PBP binding loops; other site 545693007780 ABC-ATPase subunit interface; other site 545693007781 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 545693007782 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 545693007783 putative NAD(P) binding site [chemical binding]; other site 545693007784 active site 545693007785 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 545693007786 Predicted acetyltransferase [General function prediction only]; Region: COG5628 545693007787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007788 Coenzyme A binding pocket [chemical binding]; other site 545693007789 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 545693007790 putative active site [active] 545693007791 putative metal binding site [ion binding]; other site 545693007792 Sulphur transport; Region: Sulf_transp; cl19477 545693007793 Predicted transporter component [General function prediction only]; Region: COG2391 545693007794 Sulphur transport; Region: Sulf_transp; cl19477 545693007795 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693007796 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 545693007797 dimer interface [polypeptide binding]; other site 545693007798 active site 545693007799 metal binding site [ion binding]; metal-binding site 545693007800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693007801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693007802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693007803 dimerization interface [polypeptide binding]; other site 545693007804 EamA-like transporter family; Region: EamA; pfam00892 545693007805 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693007806 EamA-like transporter family; Region: EamA; pfam00892 545693007807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007808 Coenzyme A binding pocket [chemical binding]; other site 545693007809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007810 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693007811 putative substrate translocation pore; other site 545693007812 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693007813 active site 545693007814 metal binding site [ion binding]; metal-binding site 545693007815 AAA domain; Region: AAA_17; cl19128 545693007816 AAA domain; Region: AAA_33; pfam13671 545693007817 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 545693007818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007819 NAD(P) binding site [chemical binding]; other site 545693007820 active site 545693007821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693007822 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 545693007823 NAD(P) binding site [chemical binding]; other site 545693007824 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693007825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 545693007826 DNA-binding site [nucleotide binding]; DNA binding site 545693007827 FCD domain; Region: FCD; pfam07729 545693007828 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 545693007829 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693007830 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 545693007831 catalytic core [active] 545693007832 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 545693007833 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 545693007834 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693007835 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693007836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693007837 Transporter associated domain; Region: CorC_HlyC; smart01091 545693007838 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 545693007839 Predicted membrane protein [Function unknown]; Region: COG4325 545693007840 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 545693007841 AAA domain; Region: AAA_17; cl19128 545693007842 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 545693007843 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693007844 Walker A/P-loop; other site 545693007845 ATP binding site [chemical binding]; other site 545693007846 Q-loop/lid; other site 545693007847 ABC transporter signature motif; other site 545693007848 Walker B; other site 545693007849 D-loop; other site 545693007850 H-loop/switch region; other site 545693007851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693007852 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 545693007853 Walker A/P-loop; other site 545693007854 ATP binding site [chemical binding]; other site 545693007855 Q-loop/lid; other site 545693007856 ABC transporter signature motif; other site 545693007857 Walker B; other site 545693007858 D-loop; other site 545693007859 H-loop/switch region; other site 545693007860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693007861 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 545693007862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007863 dimer interface [polypeptide binding]; other site 545693007864 conserved gate region; other site 545693007865 putative PBP binding loops; other site 545693007866 ABC-ATPase subunit interface; other site 545693007867 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693007868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007869 dimer interface [polypeptide binding]; other site 545693007870 conserved gate region; other site 545693007871 putative PBP binding loops; other site 545693007872 ABC-ATPase subunit interface; other site 545693007873 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693007874 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 545693007875 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 545693007876 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693007877 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693007878 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693007879 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693007880 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693007881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693007882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693007884 Coenzyme A binding pocket [chemical binding]; other site 545693007885 Staphylococcal nuclease homologues; Region: SNc; smart00318 545693007886 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 545693007887 Catalytic site; other site 545693007888 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 545693007889 malate:quinone oxidoreductase; Validated; Region: PRK05257 545693007890 Predicted dehydrogenase [General function prediction only]; Region: COG0579 545693007891 PEP synthetase regulatory protein; Provisional; Region: PRK05339 545693007892 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 545693007893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693007894 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693007895 active site 545693007896 motif I; other site 545693007897 motif II; other site 545693007898 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693007899 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 545693007900 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 545693007901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693007902 active site 545693007903 motif I; other site 545693007904 motif II; other site 545693007905 Uncharacterized conserved protein [Function unknown]; Region: COG4278 545693007906 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 545693007907 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 545693007908 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693007909 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693007910 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 545693007911 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 545693007912 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 545693007913 malate synthase G; Provisional; Region: PRK02999 545693007914 active site 545693007915 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007916 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 545693007917 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 545693007918 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693007919 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 545693007920 Cysteine-rich domain; Region: CCG; pfam02754 545693007921 Cysteine-rich domain; Region: CCG; pfam02754 545693007922 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 545693007923 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007924 L-lactate permease; Region: Lactate_perm; pfam02652 545693007925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007926 D-galactonate transporter; Region: 2A0114; TIGR00893 545693007927 putative substrate translocation pore; other site 545693007928 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 545693007929 putative active site [active] 545693007930 catalytic triad [active] 545693007931 putative dimer interface [polypeptide binding]; other site 545693007932 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 545693007933 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693007934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693007935 DNA-binding site [nucleotide binding]; DNA binding site 545693007936 FCD domain; Region: FCD; pfam07729 545693007937 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 545693007938 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693007939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693007940 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693007941 Walker A/P-loop; other site 545693007942 ATP binding site [chemical binding]; other site 545693007943 Q-loop/lid; other site 545693007944 ABC transporter signature motif; other site 545693007945 Walker B; other site 545693007946 D-loop; other site 545693007947 H-loop/switch region; other site 545693007948 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693007949 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 545693007950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693007951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693007952 DNA binding residues [nucleotide binding] 545693007953 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 545693007954 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693007955 yiaA/B two helix domain; Region: YiaAB; pfam05360 545693007956 Esterase/lipase [General function prediction only]; Region: COG1647 545693007957 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693007958 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693007959 active site 545693007960 dimer interface [polypeptide binding]; other site 545693007961 non-prolyl cis peptide bond; other site 545693007962 insertion regions; other site 545693007963 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693007964 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 545693007965 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693007966 oligomer interface [polypeptide binding]; other site 545693007967 metal binding site [ion binding]; metal-binding site 545693007968 metal binding site [ion binding]; metal-binding site 545693007969 putative Cl binding site [ion binding]; other site 545693007970 aspartate ring; other site 545693007971 basic sphincter; other site 545693007972 hydrophobic gate; other site 545693007973 periplasmic entrance; other site 545693007974 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 545693007975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693007976 S-adenosylmethionine binding site [chemical binding]; other site 545693007977 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693007978 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 545693007979 putative active site [active] 545693007980 putative metal binding site [ion binding]; other site 545693007981 Predicted membrane protein [Function unknown]; Region: COG2323 545693007982 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 545693007983 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 545693007984 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 545693007985 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693007986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693007987 dimerization interface [polypeptide binding]; other site 545693007988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693007989 dimer interface [polypeptide binding]; other site 545693007990 phosphorylation site [posttranslational modification] 545693007991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693007992 ATP binding site [chemical binding]; other site 545693007993 Mg2+ binding site [ion binding]; other site 545693007994 G-X-G motif; other site 545693007995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693007996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693007997 active site 545693007998 phosphorylation site [posttranslational modification] 545693007999 intermolecular recognition site; other site 545693008000 dimerization interface [polypeptide binding]; other site 545693008001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693008002 DNA binding site [nucleotide binding] 545693008003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693008004 hypothetical protein; Provisional; Region: PRK06184 545693008005 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 545693008006 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 545693008007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693008009 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 545693008010 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 545693008011 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693008012 E3 interaction surface; other site 545693008013 lipoyl attachment site [posttranslational modification]; other site 545693008014 e3 binding domain; Region: E3_binding; pfam02817 545693008015 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 545693008016 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 545693008017 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 545693008018 TPP-binding site [chemical binding]; other site 545693008019 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 545693008020 dimer interface [polypeptide binding]; other site 545693008021 PYR/PP interface [polypeptide binding]; other site 545693008022 TPP binding site [chemical binding]; other site 545693008023 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693008024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693008026 putative substrate translocation pore; other site 545693008027 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 545693008028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693008029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008030 NAD(P) binding site [chemical binding]; other site 545693008031 active site 545693008032 Predicted membrane protein [Function unknown]; Region: COG2311 545693008033 Protein of unknown function (DUF418); Region: DUF418; pfam04235 545693008034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 545693008035 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693008036 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 545693008037 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 545693008038 Walker A/P-loop; other site 545693008039 ATP binding site [chemical binding]; other site 545693008040 Q-loop/lid; other site 545693008041 ABC transporter signature motif; other site 545693008042 Walker B; other site 545693008043 D-loop; other site 545693008044 H-loop/switch region; other site 545693008045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 545693008046 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 545693008047 Walker A/P-loop; other site 545693008048 ATP binding site [chemical binding]; other site 545693008049 Q-loop/lid; other site 545693008050 ABC transporter signature motif; other site 545693008051 Walker B; other site 545693008052 D-loop; other site 545693008053 H-loop/switch region; other site 545693008054 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 545693008055 TM-ABC transporter signature motif; other site 545693008056 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 545693008057 TM-ABC transporter signature motif; other site 545693008058 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 545693008059 dimerization interface [polypeptide binding]; other site 545693008060 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 545693008061 ligand binding site [chemical binding]; other site 545693008062 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 545693008063 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 545693008064 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 545693008065 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 545693008066 active site 545693008067 putative catalytic site [active] 545693008068 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 545693008069 Interdomain contacts; other site 545693008070 Cytokine receptor motif; other site 545693008071 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693008072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693008073 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 545693008074 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693008075 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693008076 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693008077 GrpB protein; Region: GrpB; pfam04229 545693008078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693008079 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 545693008080 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 545693008081 Predicted membrane protein [Function unknown]; Region: COG4640 545693008082 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 545693008083 YARHG domain; Region: YARHG; pfam13308 545693008084 PAS domain; Region: PAS_8; pfam13188 545693008085 PAS domain; Region: PAS_9; pfam13426 545693008086 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008087 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693008088 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693008089 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693008090 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693008091 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693008092 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693008093 putative dimer interface [polypeptide binding]; other site 545693008094 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693008095 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693008096 Walker A/P-loop; other site 545693008097 ATP binding site [chemical binding]; other site 545693008098 Q-loop/lid; other site 545693008099 ABC transporter signature motif; other site 545693008100 Walker B; other site 545693008101 D-loop; other site 545693008102 H-loop/switch region; other site 545693008103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693008104 ABC-ATPase subunit interface; other site 545693008105 dimer interface [polypeptide binding]; other site 545693008106 putative PBP binding regions; other site 545693008107 cobyric acid synthase; Provisional; Region: PRK00784 545693008108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 545693008109 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 545693008110 catalytic triad [active] 545693008111 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 545693008112 putative active site [active] 545693008113 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693008114 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693008115 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 545693008116 dimer interface [polypeptide binding]; other site 545693008117 FMN binding site [chemical binding]; other site 545693008118 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693008119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008120 NAD(P) binding site [chemical binding]; other site 545693008121 active site 545693008122 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 545693008123 Inhibitor of the contact-dependent growth inhibition (CDI) system of Escherichia coli EC869, and related proteins; Region: CDI_inhibitor_EC869_like; cl06338 545693008124 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 545693008125 tetramer interface [polypeptide binding]; other site 545693008126 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693008127 active site 545693008128 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 545693008129 active site 545693008130 dimer interface [polypeptide binding]; other site 545693008131 magnesium binding site [ion binding]; other site 545693008132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693008133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693008134 DNA binding site [nucleotide binding] 545693008135 domain linker motif; other site 545693008136 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 545693008137 putative dimerization interface [polypeptide binding]; other site 545693008138 putative ligand binding site [chemical binding]; other site 545693008139 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 545693008140 active site 545693008141 intersubunit interface [polypeptide binding]; other site 545693008142 catalytic residue [active] 545693008143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008144 D-galactonate transporter; Region: 2A0114; TIGR00893 545693008145 putative substrate translocation pore; other site 545693008146 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693008147 substrate binding site [chemical binding]; other site 545693008148 ATP binding site [chemical binding]; other site 545693008149 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693008150 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693008151 phytoene desaturase; Region: crtI_fam; TIGR02734 545693008152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693008153 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 545693008154 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693008155 active site 545693008156 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 545693008157 putative acyl-acceptor binding pocket; other site 545693008158 Protein of unknown function (DUF422); Region: DUF422; cl00991 545693008159 High-affinity nickel-transport protein; Region: NicO; cl00964 545693008160 UreD urease accessory protein; Region: UreD; cl00530 545693008161 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 545693008162 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 545693008163 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 545693008164 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 545693008165 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 545693008166 dimer interface [polypeptide binding]; other site 545693008167 catalytic residues [active] 545693008168 urease subunit alpha; Reviewed; Region: ureC; PRK13207 545693008169 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 545693008170 subunit interactions [polypeptide binding]; other site 545693008171 active site 545693008172 flap region; other site 545693008173 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 545693008174 gamma-beta subunit interface [polypeptide binding]; other site 545693008175 alpha-beta subunit interface [polypeptide binding]; other site 545693008176 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 545693008177 alpha-gamma subunit interface [polypeptide binding]; other site 545693008178 beta-gamma subunit interface [polypeptide binding]; other site 545693008179 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 545693008180 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 545693008181 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 545693008182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008183 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693008184 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693008185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008186 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 545693008188 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 545693008189 dimer interface [polypeptide binding]; other site 545693008190 FMN binding site [chemical binding]; other site 545693008191 NADPH bind site [chemical binding]; other site 545693008192 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 545693008193 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 545693008194 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693008195 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 545693008196 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693008197 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 545693008198 NodB motif; other site 545693008199 putative active site [active] 545693008200 putative catalytic site [active] 545693008201 putative Zn binding site [ion binding]; other site 545693008202 Predicted esterase [General function prediction only]; Region: COG0400 545693008203 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693008204 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693008205 Transglycosylase; Region: Transgly; pfam00912 545693008206 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693008207 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 545693008208 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693008209 EamA-like transporter family; Region: EamA; pfam00892 545693008210 EamA-like transporter family; Region: EamA; pfam00892 545693008211 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693008212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693008213 DNA-binding site [nucleotide binding]; DNA binding site 545693008214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693008215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693008216 homodimer interface [polypeptide binding]; other site 545693008217 catalytic residue [active] 545693008218 YtkA-like; Region: YtkA; pfam13115 545693008219 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 545693008220 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693008221 potential catalytic triad [active] 545693008222 conserved cys residue [active] 545693008223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693008224 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693008225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693008226 Walker A/P-loop; other site 545693008227 ATP binding site [chemical binding]; other site 545693008228 Q-loop/lid; other site 545693008229 ABC transporter signature motif; other site 545693008230 Walker B; other site 545693008231 D-loop; other site 545693008232 H-loop/switch region; other site 545693008233 Copper resistance protein D; Region: CopD; cl00563 545693008234 CopC domain; Region: CopC; pfam04234 545693008235 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 545693008236 Protein of unknown function (DUF867); Region: DUF867; pfam05908 545693008237 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 545693008238 Ferritin-like domain; Region: Ferritin; pfam00210 545693008239 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 545693008240 dimerization interface [polypeptide binding]; other site 545693008241 DPS ferroxidase diiron center [ion binding]; other site 545693008242 ion pore; other site 545693008243 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 545693008244 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693008245 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693008246 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693008247 Transporter associated domain; Region: CorC_HlyC; smart01091 545693008248 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 545693008249 FOG: CBS domain [General function prediction only]; Region: COG0517 545693008250 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 545693008251 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693008252 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 545693008253 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 545693008254 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 545693008255 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 545693008256 [2Fe-2S] cluster binding site [ion binding]; other site 545693008257 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 545693008258 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 545693008259 hinge; other site 545693008260 active site 545693008261 prephenate dehydrogenase; Validated; Region: PRK08507 545693008262 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 545693008263 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 545693008264 Tetramer interface [polypeptide binding]; other site 545693008265 active site 545693008266 FMN-binding site [chemical binding]; other site 545693008267 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 545693008268 Chorismate mutase type II; Region: CM_2; cl00693 545693008269 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 545693008270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008271 Coenzyme A binding pocket [chemical binding]; other site 545693008272 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 545693008273 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 545693008274 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 545693008275 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 545693008276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693008277 catalytic residue [active] 545693008278 allantoate amidohydrolase; Reviewed; Region: PRK09290 545693008279 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 545693008280 active site 545693008281 metal binding site [ion binding]; metal-binding site 545693008282 dimer interface [polypeptide binding]; other site 545693008283 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 545693008284 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 545693008285 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693008286 Domain of unknown function DUF77; Region: DUF77; pfam01910 545693008287 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693008288 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693008289 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693008290 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693008291 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693008292 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693008293 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693008294 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 545693008295 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 545693008296 tetramer interface [polypeptide binding]; other site 545693008297 heme binding pocket [chemical binding]; other site 545693008298 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 545693008299 Na2 binding site [ion binding]; other site 545693008300 putative substrate binding site 1 [chemical binding]; other site 545693008301 Na binding site 1 [ion binding]; other site 545693008302 putative substrate binding site 2 [chemical binding]; other site 545693008303 Predicted membrane protein [Function unknown]; Region: COG3766 545693008304 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693008305 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693008306 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 545693008307 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693008308 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 545693008309 phosphate binding site [ion binding]; other site 545693008310 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693008311 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693008312 Catalytic site [active] 545693008313 FOG: CBS domain [General function prediction only]; Region: COG0517 545693008314 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 545693008315 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 545693008316 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 545693008317 Ligand Binding Site [chemical binding]; other site 545693008318 K+-transporting ATPase, c chain; Region: KdpC; cl00944 545693008319 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 545693008320 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693008321 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 545693008322 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 545693008323 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 545693008324 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 545693008325 active site 545693008326 homodimer interface [polypeptide binding]; other site 545693008327 CHY zinc finger; Region: zf-CHY; cl19861 545693008328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693008329 dimerization interface [polypeptide binding]; other site 545693008330 putative DNA binding site [nucleotide binding]; other site 545693008331 putative Zn2+ binding site [ion binding]; other site 545693008332 Uncharacterized conserved protein [Function unknown]; Region: COG1359 545693008333 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 545693008334 dimer interface [polypeptide binding]; other site 545693008335 FMN binding site [chemical binding]; other site 545693008336 NADPH bind site [chemical binding]; other site 545693008337 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693008338 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693008339 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693008340 GrpB protein; Region: GrpB; pfam04229 545693008341 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693008342 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693008343 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693008344 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693008345 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693008346 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693008347 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693008348 active site 545693008349 metal binding site [ion binding]; metal-binding site 545693008350 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 545693008351 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693008352 DinB family; Region: DinB; cl17821 545693008353 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693008354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693008355 S-adenosylmethionine binding site [chemical binding]; other site 545693008356 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 545693008357 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 545693008358 phosphopeptide binding site; other site 545693008359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693008360 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 545693008361 DNA binding site [nucleotide binding] 545693008362 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 545693008363 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 545693008364 putative dimer interface [polypeptide binding]; other site 545693008365 active site pocket [active] 545693008366 putative cataytic base [active] 545693008367 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008368 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008369 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008370 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693008371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693008372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008373 Coenzyme A binding pocket [chemical binding]; other site 545693008374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008375 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693008376 putative substrate translocation pore; other site 545693008377 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008378 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008379 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 545693008380 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 545693008381 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 545693008382 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 545693008383 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 545693008384 dimer interface [polypeptide binding]; other site 545693008385 active site 545693008386 citrylCoA binding site [chemical binding]; other site 545693008387 oxalacetate/citrate binding site [chemical binding]; other site 545693008388 coenzyme A binding site [chemical binding]; other site 545693008389 catalytic triad [active] 545693008390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693008391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693008392 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 545693008393 putative dimerization interface [polypeptide binding]; other site 545693008394 EamA-like transporter family; Region: EamA; pfam00892 545693008395 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693008396 EamA-like transporter family; Region: EamA; pfam00892 545693008397 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693008398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693008399 DNA-binding site [nucleotide binding]; DNA binding site 545693008400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693008401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693008402 homodimer interface [polypeptide binding]; other site 545693008403 catalytic residue [active] 545693008404 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 545693008405 B12 binding domain; Region: B12-binding_2; pfam02607 545693008406 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 545693008407 B12 binding site [chemical binding]; other site 545693008408 PAS domain; Region: PAS_9; pfam13426 545693008409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693008410 putative active site [active] 545693008411 heme pocket [chemical binding]; other site 545693008412 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008413 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008414 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693008415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 545693008416 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 545693008417 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693008418 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008419 Predicted membrane protein [Function unknown]; Region: COG2261 545693008420 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 545693008421 oligomer interface [polypeptide binding]; other site 545693008422 active site residues [active] 545693008423 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 545693008424 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693008425 DNA binding residues [nucleotide binding] 545693008426 dimer interface [polypeptide binding]; other site 545693008427 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 545693008428 nucleotide binding site/active site [active] 545693008429 HIT family signature motif; other site 545693008430 catalytic residue [active] 545693008431 aspartate ammonia-lyase; Provisional; Region: PRK14515 545693008432 Aspartase; Region: Aspartase; cd01357 545693008433 active sites [active] 545693008434 tetramer interface [polypeptide binding]; other site 545693008435 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 545693008436 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 545693008437 active site 545693008438 homodimer interface [polypeptide binding]; other site 545693008439 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693008440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693008441 non-specific DNA binding site [nucleotide binding]; other site 545693008442 salt bridge; other site 545693008443 sequence-specific DNA binding site [nucleotide binding]; other site 545693008444 chaperone protein DnaJ; Provisional; Region: PRK14289 545693008445 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 545693008446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008447 putative substrate translocation pore; other site 545693008448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693008449 dimerization interface [polypeptide binding]; other site 545693008450 putative DNA binding site [nucleotide binding]; other site 545693008451 putative Zn2+ binding site [ion binding]; other site 545693008452 Protein of unknown function, DUF606; Region: DUF606; pfam04657 545693008453 Protein of unknown function, DUF606; Region: DUF606; pfam04657 545693008454 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693008455 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693008456 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693008457 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693008458 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 545693008459 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 545693008460 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693008461 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 545693008462 putative NAD(P) binding site [chemical binding]; other site 545693008463 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 545693008464 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693008465 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693008466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693008467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008468 Coenzyme A binding pocket [chemical binding]; other site 545693008469 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693008470 classical (c) SDRs; Region: SDR_c; cd05233 545693008471 NAD(P) binding site [chemical binding]; other site 545693008472 active site 545693008473 sulfite reductase subunit beta; Provisional; Region: PRK13504 545693008474 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693008475 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 545693008476 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693008477 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 545693008478 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 545693008479 Flavodoxin; Region: Flavodoxin_1; pfam00258 545693008480 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 545693008481 FAD binding pocket [chemical binding]; other site 545693008482 FAD binding motif [chemical binding]; other site 545693008483 catalytic residues [active] 545693008484 NAD binding pocket [chemical binding]; other site 545693008485 phosphate binding motif [ion binding]; other site 545693008486 beta-alpha-beta structure motif; other site 545693008487 YolD-like protein; Region: YolD; pfam08863 545693008488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693008490 putative substrate translocation pore; other site 545693008491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693008492 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693008493 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693008494 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 545693008495 DNA binding residues [nucleotide binding] 545693008496 dimer interface [polypeptide binding]; other site 545693008497 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 545693008498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008499 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693008500 Coenzyme A binding pocket [chemical binding]; other site 545693008501 Rhamnan synthesis protein F; Region: RgpF; pfam05045 545693008502 Spore germination protein; Region: Spore_permease; cl17796 545693008503 CAAX protease self-immunity; Region: Abi; pfam02517 545693008504 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 545693008505 glycosyltransferase, MGT family; Region: MGT; TIGR01426 545693008506 active site 545693008507 TDP-binding site; other site 545693008508 acceptor substrate-binding pocket; other site 545693008509 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 545693008510 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 545693008511 FMN binding site [chemical binding]; other site 545693008512 active site 545693008513 substrate binding site [chemical binding]; other site 545693008514 catalytic residue [active] 545693008515 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 545693008516 active site 545693008517 catalytic triad [active] 545693008518 oxyanion hole [active] 545693008519 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 545693008520 MMPL family; Region: MMPL; cl14618 545693008521 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 545693008522 MMPL family; Region: MMPL; cl14618 545693008523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693008525 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 545693008526 imidazolonepropionase; Validated; Region: PRK09356 545693008527 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 545693008528 active site 545693008529 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693008530 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008532 Coenzyme A binding pocket [chemical binding]; other site 545693008533 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 545693008534 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 545693008535 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 545693008536 Subunit I/III interface [polypeptide binding]; other site 545693008537 Subunit III/IV interface [polypeptide binding]; other site 545693008538 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 545693008539 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 545693008540 D-pathway; other site 545693008541 Putative ubiquinol binding site [chemical binding]; other site 545693008542 Low-spin heme (heme b) binding site [chemical binding]; other site 545693008543 Putative water exit pathway; other site 545693008544 Binuclear center (heme o3/CuB) [ion binding]; other site 545693008545 K-pathway; other site 545693008546 Putative proton exit pathway; other site 545693008547 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 545693008548 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 545693008549 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 545693008550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 545693008551 active site residue [active] 545693008552 PAS domain; Region: PAS; smart00091 545693008553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693008554 dimerization interface [polypeptide binding]; other site 545693008555 putative DNA binding site [nucleotide binding]; other site 545693008556 putative Zn2+ binding site [ion binding]; other site 545693008557 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693008558 metal-binding site [ion binding] 545693008559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693008560 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693008561 metal-binding site [ion binding] 545693008562 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693008563 Soluble P-type ATPase [General function prediction only]; Region: COG4087 545693008564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693008565 S-adenosylmethionine binding site [chemical binding]; other site 545693008566 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 545693008567 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693008568 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693008569 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693008570 active site 545693008571 metal binding site [ion binding]; metal-binding site 545693008572 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693008573 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008574 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693008575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008576 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 545693008577 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693008578 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693008579 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693008580 catalytic residues [active] 545693008581 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 545693008582 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 545693008583 active site 545693008584 catalytic site [active] 545693008585 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693008586 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693008588 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 545693008589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008590 active site 545693008591 motif I; other site 545693008592 motif II; other site 545693008593 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008595 Prostaglandin dehydrogenases; Region: PGDH; cd05288 545693008596 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 545693008597 NAD(P) binding site [chemical binding]; other site 545693008598 substrate binding site [chemical binding]; other site 545693008599 dimer interface [polypeptide binding]; other site 545693008600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 545693008601 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008602 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008603 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008604 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693008605 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 545693008606 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 545693008607 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 545693008608 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 545693008609 Thioredoxin; Region: Thioredoxin_4; pfam13462 545693008610 Peptidase family M48; Region: Peptidase_M48; cl12018 545693008611 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 545693008612 Penicillinase repressor; Region: Penicillinase_R; cl17580 545693008613 YvrJ protein family; Region: YvrJ; pfam12841 545693008614 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 545693008615 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 545693008616 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 545693008617 Divergent AAA domain; Region: AAA_4; pfam04326 545693008618 hypothetical protein; Validated; Region: PRK06769 545693008619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008620 active site 545693008621 motif I; other site 545693008622 motif II; other site 545693008623 Protein of unknown function (DUF867); Region: DUF867; pfam05908 545693008624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693008626 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 545693008627 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 545693008628 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 545693008629 G1 box; other site 545693008630 putative GEF interaction site [polypeptide binding]; other site 545693008631 GTP/Mg2+ binding site [chemical binding]; other site 545693008632 Switch I region; other site 545693008633 G2 box; other site 545693008634 G3 box; other site 545693008635 Switch II region; other site 545693008636 G4 box; other site 545693008637 G5 box; other site 545693008638 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 545693008639 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693008640 DNA-binding site [nucleotide binding]; DNA binding site 545693008641 RNA-binding motif; other site 545693008642 Predicted membrane protein [Function unknown]; Region: COG2323 545693008643 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 545693008644 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 545693008645 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693008646 NAD binding site [chemical binding]; other site 545693008647 substrate binding site [chemical binding]; other site 545693008648 putative active site [active] 545693008649 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 545693008650 Double zinc ribbon; Region: DZR; pfam12773 545693008651 Protease prsW family; Region: PrsW-protease; cl15823 545693008652 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 545693008653 dimanganese center [ion binding]; other site 545693008654 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 545693008655 dimanganese center [ion binding]; other site 545693008656 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 545693008657 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 545693008658 putative ligand binding residues [chemical binding]; other site 545693008659 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 545693008660 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693008661 Walker A/P-loop; other site 545693008662 ATP binding site [chemical binding]; other site 545693008663 Q-loop/lid; other site 545693008664 ABC transporter signature motif; other site 545693008665 Walker B; other site 545693008666 D-loop; other site 545693008667 H-loop/switch region; other site 545693008668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693008669 ABC-ATPase subunit interface; other site 545693008670 dimer interface [polypeptide binding]; other site 545693008671 putative PBP binding regions; other site 545693008672 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693008673 ABC-ATPase subunit interface; other site 545693008674 dimer interface [polypeptide binding]; other site 545693008675 putative PBP binding regions; other site 545693008676 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008677 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693008678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693008679 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693008680 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693008681 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 545693008682 putative NAD(P) binding site [chemical binding]; other site 545693008683 catalytic Zn binding site [ion binding]; other site 545693008684 structural Zn binding site [ion binding]; other site 545693008685 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693008686 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 545693008687 putative NAD(P) binding site [chemical binding]; other site 545693008688 catalytic Zn binding site [ion binding]; other site 545693008689 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 545693008690 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 545693008691 active site 545693008692 P-loop; other site 545693008693 phosphorylation site [posttranslational modification] 545693008694 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 545693008695 active site 545693008696 P-loop; other site 545693008697 phosphorylation site [posttranslational modification] 545693008698 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693008699 active site 545693008700 phosphorylation site [posttranslational modification] 545693008701 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693008702 PRD domain; Region: PRD; pfam00874 545693008703 PRD domain; Region: PRD; pfam00874 545693008704 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693008705 active site 545693008706 P-loop; other site 545693008707 phosphorylation site [posttranslational modification] 545693008708 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693008709 active site 545693008710 phosphorylation site [posttranslational modification] 545693008711 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 545693008712 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693008713 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693008714 Catalytic site [active] 545693008715 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 545693008716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 545693008717 Protein of unknown function (DUF975); Region: DUF975; cl10504 545693008718 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693008719 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693008720 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 545693008721 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 545693008722 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 545693008723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693008724 catalytic residue [active] 545693008725 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 545693008726 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 545693008727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008728 motif II; other site 545693008729 MutS domain III; Region: MutS_III; pfam05192 545693008730 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 545693008731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693008732 Walker A/P-loop; other site 545693008733 ATP binding site [chemical binding]; other site 545693008734 Q-loop/lid; other site 545693008735 ABC transporter signature motif; other site 545693008736 Walker B; other site 545693008737 D-loop; other site 545693008738 H-loop/switch region; other site 545693008739 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 545693008740 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 545693008741 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 545693008742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693008743 non-specific DNA binding site [nucleotide binding]; other site 545693008744 salt bridge; other site 545693008745 sequence-specific DNA binding site [nucleotide binding]; other site 545693008746 Cupin domain; Region: Cupin_2; pfam07883 545693008747 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 545693008748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693008749 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693008750 DNA binding site [nucleotide binding] 545693008751 domain linker motif; other site 545693008752 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 545693008753 dimerization interface [polypeptide binding]; other site 545693008754 ligand binding site [chemical binding]; other site 545693008755 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693008756 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693008757 SnoaL-like domain; Region: SnoaL_2; pfam12680 545693008758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693008759 Radical SAM superfamily; Region: Radical_SAM; pfam04055 545693008760 FeS/SAM binding site; other site 545693008761 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008762 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 545693008763 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008764 Gas vesicle protein G; Region: GvpG; pfam05120 545693008765 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008766 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008767 Gas vesicle protein K; Region: GvpK; pfam05121 545693008768 Gas vesicle protein; Region: Gas_vesicle; pfam00741 545693008769 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693008770 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 545693008771 folate binding site [chemical binding]; other site 545693008772 NADP+ binding site [chemical binding]; other site 545693008773 Predicted transcriptional regulator [Transcription]; Region: COG2378 545693008774 HTH domain; Region: HTH_11; pfam08279 545693008775 WYL domain; Region: WYL; pfam13280 545693008776 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 545693008777 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 545693008778 Flavodoxin; Region: Flavodoxin_1; pfam00258 545693008779 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 545693008780 FAD binding pocket [chemical binding]; other site 545693008781 FAD binding motif [chemical binding]; other site 545693008782 catalytic residues [active] 545693008783 NAD binding pocket [chemical binding]; other site 545693008784 phosphate binding motif [ion binding]; other site 545693008785 beta-alpha-beta structure motif; other site 545693008786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693008788 Pleckstrin homology-like domain; Region: PH-like; cl17171 545693008789 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 545693008790 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 545693008791 dimanganese center [ion binding]; other site 545693008792 CotJB protein; Region: CotJB; pfam12652 545693008793 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 545693008794 putative scaffolding protein; Region: PHA01929 545693008795 LysE type translocator; Region: LysE; cl00565 545693008796 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 545693008797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693008798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693008799 Histidine kinase; Region: HisKA_3; pfam07730 545693008800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008801 ATP binding site [chemical binding]; other site 545693008802 Mg2+ binding site [ion binding]; other site 545693008803 G-X-G motif; other site 545693008804 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693008805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693008806 active site 545693008807 phosphorylation site [posttranslational modification] 545693008808 intermolecular recognition site; other site 545693008809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693008810 DNA binding residues [nucleotide binding] 545693008811 dimerization interface [polypeptide binding]; other site 545693008812 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 545693008813 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693008814 putative active site [active] 545693008815 catalytic site [active] 545693008816 putative metal binding site [ion binding]; other site 545693008817 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 545693008818 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 545693008819 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693008820 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 545693008821 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693008822 YtkA-like; Region: YtkA; pfam13115 545693008823 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 545693008824 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 545693008825 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693008826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693008828 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 545693008829 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 545693008830 homodimer interface [polypeptide binding]; other site 545693008831 active site 545693008832 TDP-binding site; other site 545693008833 acceptor substrate-binding pocket; other site 545693008834 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693008835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008836 Coenzyme A binding pocket [chemical binding]; other site 545693008837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693008838 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693008839 active site 545693008840 intersubunit interactions; other site 545693008841 catalytic residue [active] 545693008842 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 545693008843 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693008844 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 545693008845 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 545693008846 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 545693008847 TPP-binding site [chemical binding]; other site 545693008848 dimer interface [polypeptide binding]; other site 545693008849 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693008850 PYR/PP interface [polypeptide binding]; other site 545693008851 dimer interface [polypeptide binding]; other site 545693008852 TPP binding site [chemical binding]; other site 545693008853 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693008854 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693008855 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693008856 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693008857 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 545693008858 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008859 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693008861 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 545693008862 AAA domain; Region: AAA_17; pfam13207 545693008863 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693008864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 545693008865 Walker A/P-loop; other site 545693008866 ATP binding site [chemical binding]; other site 545693008867 Q-loop/lid; other site 545693008868 ABC transporter signature motif; other site 545693008869 Walker B; other site 545693008870 D-loop; other site 545693008871 H-loop/switch region; other site 545693008872 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693008873 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 545693008874 FtsX-like permease family; Region: FtsX; pfam02687 545693008875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693008876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693008877 dimerization interface [polypeptide binding]; other site 545693008878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693008879 dimer interface [polypeptide binding]; other site 545693008880 phosphorylation site [posttranslational modification] 545693008881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008882 ATP binding site [chemical binding]; other site 545693008883 Mg2+ binding site [ion binding]; other site 545693008884 G-X-G motif; other site 545693008885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693008886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693008887 active site 545693008888 phosphorylation site [posttranslational modification] 545693008889 intermolecular recognition site; other site 545693008890 dimerization interface [polypeptide binding]; other site 545693008891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693008892 DNA binding site [nucleotide binding] 545693008893 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 545693008894 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 545693008895 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 545693008896 GAF domain; Region: GAF; pfam01590 545693008897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693008898 dimer interface [polypeptide binding]; other site 545693008899 phosphorylation site [posttranslational modification] 545693008900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008901 ATP binding site [chemical binding]; other site 545693008902 Mg2+ binding site [ion binding]; other site 545693008903 G-X-G motif; other site 545693008904 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693008906 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 545693008907 FAD dependent oxidoreductase; Region: DAO; pfam01266 545693008908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008909 Coenzyme A binding pocket [chemical binding]; other site 545693008910 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693008911 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693008912 DNA binding residues [nucleotide binding] 545693008913 putative dimer interface [polypeptide binding]; other site 545693008914 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693008915 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 545693008916 active site 545693008917 catalytic tetrad [active] 545693008918 EamA-like transporter family; Region: EamA; pfam00892 545693008919 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693008920 EamA-like transporter family; Region: EamA; pfam00892 545693008921 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 545693008922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693008923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693008924 YtxH-like protein; Region: YtxH; pfam12732 545693008925 Gas vesicle protein; Region: Gas_vesicle; pfam00741 545693008926 Gas vesicle protein K; Region: GvpK; pfam05121 545693008927 Gas vesicle protein; Region: Gas_vesicle; pfam00741 545693008928 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008929 Gas vesicle protein G; Region: GvpG; pfam05120 545693008930 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008931 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 545693008932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693008933 Walker A motif; other site 545693008934 ATP binding site [chemical binding]; other site 545693008935 Walker B motif; other site 545693008936 arginine finger; other site 545693008937 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 545693008938 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 545693008939 YtxH-like protein; Region: YtxH; pfam12732 545693008940 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 545693008941 Heat induced stress protein YflT; Region: YflT; pfam11181 545693008942 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693008943 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 545693008944 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 545693008945 PhnA protein; Region: PhnA; pfam03831 545693008946 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 545693008947 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 545693008948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693008949 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693008950 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 545693008951 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 545693008952 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 545693008953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693008954 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 545693008955 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 545693008956 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693008957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693008958 dimer interface [polypeptide binding]; other site 545693008959 conserved gate region; other site 545693008960 putative PBP binding loops; other site 545693008961 ABC-ATPase subunit interface; other site 545693008962 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 545693008963 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693008964 substrate binding pocket [chemical binding]; other site 545693008965 membrane-bound complex binding site; other site 545693008966 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693008967 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 545693008968 Walker A/P-loop; other site 545693008969 ATP binding site [chemical binding]; other site 545693008970 Q-loop/lid; other site 545693008971 ABC transporter signature motif; other site 545693008972 Walker B; other site 545693008973 D-loop; other site 545693008974 H-loop/switch region; other site 545693008975 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 545693008976 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 545693008977 active site 545693008978 iron coordination sites [ion binding]; other site 545693008979 benzoate transport; Region: 2A0115; TIGR00895 545693008980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008981 putative substrate translocation pore; other site 545693008982 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008984 Coenzyme A binding pocket [chemical binding]; other site 545693008985 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693008986 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 545693008987 metal binding site [ion binding]; metal-binding site 545693008988 dimer interface [polypeptide binding]; other site 545693008989 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693008990 active site 545693008991 non-prolyl cis peptide bond; other site 545693008992 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693008993 active site 545693008994 dimer interface [polypeptide binding]; other site 545693008995 non-prolyl cis peptide bond; other site 545693008996 insertion regions; other site 545693008997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693008998 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693008999 active site 545693009000 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693009001 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 545693009002 putative NAD(P) binding site [chemical binding]; other site 545693009003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693009004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693009005 active site 545693009006 phosphorylation site [posttranslational modification] 545693009007 intermolecular recognition site; other site 545693009008 dimerization interface [polypeptide binding]; other site 545693009009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693009010 DNA binding site [nucleotide binding] 545693009011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693009012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693009013 dimer interface [polypeptide binding]; other site 545693009014 phosphorylation site [posttranslational modification] 545693009015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693009016 ATP binding site [chemical binding]; other site 545693009017 Mg2+ binding site [ion binding]; other site 545693009018 G-X-G motif; other site 545693009019 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693009020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 545693009021 Walker A/P-loop; other site 545693009022 ATP binding site [chemical binding]; other site 545693009023 Q-loop/lid; other site 545693009024 ABC transporter signature motif; other site 545693009025 Walker B; other site 545693009026 D-loop; other site 545693009027 H-loop/switch region; other site 545693009028 FtsX-like permease family; Region: FtsX; pfam02687 545693009029 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693009030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693009031 Dienelactone hydrolase family; Region: DLH; pfam01738 545693009032 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 545693009033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693009034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693009035 homodimer interface [polypeptide binding]; other site 545693009036 catalytic residue [active] 545693009037 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693009038 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 545693009039 CPxP motif; other site 545693009040 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 545693009041 active site residue [active] 545693009042 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693009043 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 545693009044 CPxP motif; other site 545693009045 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693009046 active site residue [active] 545693009047 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693009048 active site residue [active] 545693009049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693009050 active site residue [active] 545693009051 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 545693009052 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 545693009053 CPxP motif; other site 545693009054 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 545693009055 putative homodimer interface [polypeptide binding]; other site 545693009056 putative homotetramer interface [polypeptide binding]; other site 545693009057 putative metal binding site [ion binding]; other site 545693009058 putative homodimer-homodimer interface [polypeptide binding]; other site 545693009059 putative allosteric switch controlling residues; other site 545693009060 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 545693009061 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 545693009062 NAD binding site [chemical binding]; other site 545693009063 homotetramer interface [polypeptide binding]; other site 545693009064 homodimer interface [polypeptide binding]; other site 545693009065 substrate binding site [chemical binding]; other site 545693009066 active site 545693009067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009070 dimerization interface [polypeptide binding]; other site 545693009071 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693009072 EamA-like transporter family; Region: EamA; pfam00892 545693009073 EamA-like transporter family; Region: EamA; pfam00892 545693009074 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693009075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009076 Coenzyme A binding pocket [chemical binding]; other site 545693009077 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693009078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009079 DNA-binding site [nucleotide binding]; DNA binding site 545693009080 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 545693009081 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 545693009082 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693009083 active site turn [active] 545693009084 phosphorylation site [posttranslational modification] 545693009085 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693009086 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 545693009087 HPr interaction site; other site 545693009088 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693009089 active site 545693009090 phosphorylation site [posttranslational modification] 545693009091 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 545693009092 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 545693009093 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 545693009094 Na binding site [ion binding]; other site 545693009095 substrate binding site [chemical binding]; other site 545693009096 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 545693009097 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 545693009098 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 545693009099 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 545693009100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009101 non-specific DNA binding site [nucleotide binding]; other site 545693009102 salt bridge; other site 545693009103 sequence-specific DNA binding site [nucleotide binding]; other site 545693009104 Cupin domain; Region: Cupin_2; pfam07883 545693009105 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 545693009106 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 545693009107 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 545693009108 DNA binding site [nucleotide binding] 545693009109 active site 545693009110 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693009111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009113 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693009114 putative dimerization interface [polypeptide binding]; other site 545693009115 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693009116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009117 putative substrate translocation pore; other site 545693009118 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693009119 active site 545693009120 metal binding site [ion binding]; metal-binding site 545693009121 histidinol-phosphatase; Provisional; Region: PRK07328 545693009122 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 545693009123 active site 545693009124 dimer interface [polypeptide binding]; other site 545693009125 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 545693009126 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 545693009127 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 545693009128 glucose-1-dehydrogenase; Provisional; Region: PRK08936 545693009129 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 545693009130 NAD binding site [chemical binding]; other site 545693009131 homodimer interface [polypeptide binding]; other site 545693009132 active site 545693009133 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 545693009134 dimer interface [polypeptide binding]; other site 545693009135 FMN binding site [chemical binding]; other site 545693009136 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 545693009137 NAD(P) binding site [chemical binding]; other site 545693009138 catalytic residues [active] 545693009139 Predicted membrane protein [Function unknown]; Region: COG4325 545693009140 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 545693009141 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 545693009142 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 545693009143 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693009144 Predicted transcriptional regulators [Transcription]; Region: COG1733 545693009145 dimerization interface [polypeptide binding]; other site 545693009146 putative DNA binding site [nucleotide binding]; other site 545693009147 putative Zn2+ binding site [ion binding]; other site 545693009148 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693009149 azoreductase; Reviewed; Region: PRK00170 545693009150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693009151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693009152 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 545693009153 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 545693009154 Zn binding site [ion binding]; other site 545693009155 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 545693009156 Zn binding site [ion binding]; other site 545693009157 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 545693009158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009159 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693009160 conserved hypothetical protein; Region: TIGR02231 545693009161 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 545693009162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 545693009163 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 545693009164 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 545693009165 Protein of unknown function DUF45; Region: DUF45; pfam01863 545693009166 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 545693009167 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693009168 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693009169 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693009170 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693009171 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693009172 DNA-binding site [nucleotide binding]; DNA binding site 545693009173 RNA-binding motif; other site 545693009174 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693009175 DNA-binding site [nucleotide binding]; DNA binding site 545693009176 RNA-binding motif; other site 545693009177 proline/glycine betaine transporter; Provisional; Region: PRK10642 545693009178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009179 putative substrate translocation pore; other site 545693009180 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693009181 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 545693009182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693009183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693009184 dimer interface [polypeptide binding]; other site 545693009185 conserved gate region; other site 545693009186 putative PBP binding loops; other site 545693009187 ABC-ATPase subunit interface; other site 545693009188 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693009189 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693009190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693009191 dimer interface [polypeptide binding]; other site 545693009192 conserved gate region; other site 545693009193 putative PBP binding loops; other site 545693009194 ABC-ATPase subunit interface; other site 545693009195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693009196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693009197 Walker A/P-loop; other site 545693009198 ATP binding site [chemical binding]; other site 545693009199 Q-loop/lid; other site 545693009200 ABC transporter signature motif; other site 545693009201 Walker B; other site 545693009202 D-loop; other site 545693009203 H-loop/switch region; other site 545693009204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693009205 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 545693009206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 545693009207 Walker A/P-loop; other site 545693009208 ATP binding site [chemical binding]; other site 545693009209 Q-loop/lid; other site 545693009210 ABC transporter signature motif; other site 545693009211 Walker B; other site 545693009212 D-loop; other site 545693009213 H-loop/switch region; other site 545693009214 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693009215 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 545693009216 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 545693009217 active site 545693009218 iron coordination sites [ion binding]; other site 545693009219 substrate binding pocket [chemical binding]; other site 545693009220 threonine synthase; Validated; Region: PRK06260 545693009221 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 545693009222 homodimer interface [polypeptide binding]; other site 545693009223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693009224 catalytic residue [active] 545693009225 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693009226 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 545693009227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693009228 putative DNA binding site [nucleotide binding]; other site 545693009229 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693009230 putative Zn2+ binding site [ion binding]; other site 545693009231 MarR family; Region: MarR_2; cl17246 545693009232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009234 putative substrate translocation pore; other site 545693009235 short chain dehydrogenase; Provisional; Region: PRK06172 545693009236 classical (c) SDRs; Region: SDR_c; cd05233 545693009237 NAD(P) binding site [chemical binding]; other site 545693009238 active site 545693009239 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 545693009240 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 545693009241 active site 545693009242 substrate binding pocket [chemical binding]; other site 545693009243 homodimer interaction site [polypeptide binding]; other site 545693009244 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 545693009245 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 545693009246 intersubunit interface [polypeptide binding]; other site 545693009247 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 545693009248 Sulfate transporter family; Region: Sulfate_transp; pfam00916 545693009249 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 545693009250 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 545693009251 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 545693009252 putative active site [active] 545693009253 putative catalytic site [active] 545693009254 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 545693009255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009256 putative substrate translocation pore; other site 545693009257 Protein of unknown function DUF111; Region: DUF111; cl03398 545693009258 Protein of unknown function DUF111; Region: DUF111; cl03398 545693009259 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 545693009260 AIR carboxylase; Region: AIRC; smart01001 545693009261 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 545693009262 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 545693009263 Ligand Binding Site [chemical binding]; other site 545693009264 D-mannonate oxidoreductase; Provisional; Region: PRK08277 545693009265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009266 NAD(P) binding site [chemical binding]; other site 545693009267 active site 545693009268 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 545693009269 glucuronate isomerase; Reviewed; Region: PRK02925 545693009270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 545693009271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 545693009272 nucleotide binding site [chemical binding]; other site 545693009273 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693009274 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 545693009275 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 545693009276 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693009277 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693009278 Walker A/P-loop; other site 545693009279 ATP binding site [chemical binding]; other site 545693009280 Q-loop/lid; other site 545693009281 ABC transporter signature motif; other site 545693009282 Walker B; other site 545693009283 D-loop; other site 545693009284 H-loop/switch region; other site 545693009285 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 545693009286 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 545693009287 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 545693009288 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 545693009289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693009290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693009291 DNA binding residues [nucleotide binding] 545693009292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693009293 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693009294 active site 545693009295 motif I; other site 545693009296 motif II; other site 545693009297 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693009298 Erythromycin esterase; Region: Erythro_esteras; cl17110 545693009299 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 545693009300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009301 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 545693009302 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 545693009303 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 545693009304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009305 salt bridge; other site 545693009306 non-specific DNA binding site [nucleotide binding]; other site 545693009307 sequence-specific DNA binding site [nucleotide binding]; other site 545693009308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009309 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693009310 Coenzyme A binding pocket [chemical binding]; other site 545693009311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693009314 dimerization interface [polypeptide binding]; other site 545693009315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693009316 classical (c) SDRs; Region: SDR_c; cd05233 545693009317 NAD(P) binding site [chemical binding]; other site 545693009318 active site 545693009319 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 545693009320 active site 545693009321 NTP binding site [chemical binding]; other site 545693009322 metal binding triad [ion binding]; metal-binding site 545693009323 antibiotic binding site [chemical binding]; other site 545693009324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693009325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693009326 DNA binding site [nucleotide binding] 545693009327 domain linker motif; other site 545693009328 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 545693009329 dimerization interface [polypeptide binding]; other site 545693009330 ligand binding site [chemical binding]; other site 545693009331 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693009332 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693009333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693009334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693009335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693009336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009338 putative substrate translocation pore; other site 545693009339 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 545693009340 tetrameric interface [polypeptide binding]; other site 545693009341 NAD binding site [chemical binding]; other site 545693009342 catalytic residues [active] 545693009343 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693009344 substrate binding site [chemical binding]; other site 545693009345 ATP binding site [chemical binding]; other site 545693009346 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 545693009347 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 545693009348 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693009349 PYR/PP interface [polypeptide binding]; other site 545693009350 dimer interface [polypeptide binding]; other site 545693009351 TPP binding site [chemical binding]; other site 545693009352 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693009353 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 545693009354 TPP-binding site; other site 545693009355 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693009356 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 545693009357 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 545693009358 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 545693009359 intersubunit interface [polypeptide binding]; other site 545693009360 active site 545693009361 zinc binding site [ion binding]; other site 545693009362 Na+ binding site [ion binding]; other site 545693009363 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693009364 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693009365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009366 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 545693009367 putative substrate translocation pore; other site 545693009368 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693009369 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693009370 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 545693009371 regulatory protein interface [polypeptide binding]; other site 545693009372 active site 545693009373 regulatory phosphorylation site [posttranslational modification]; other site 545693009374 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 545693009375 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 545693009376 putative NAD(P) binding site [chemical binding]; other site 545693009377 putative substrate binding site [chemical binding]; other site 545693009378 catalytic Zn binding site [ion binding]; other site 545693009379 structural Zn binding site [ion binding]; other site 545693009380 dimer interface [polypeptide binding]; other site 545693009381 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693009382 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693009383 DNA binding residues [nucleotide binding] 545693009384 putative dimer interface [polypeptide binding]; other site 545693009385 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693009386 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 545693009387 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 545693009388 nucleotide binding site [chemical binding]; other site 545693009389 putative protofilament interface [polypeptide binding]; other site 545693009390 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693009391 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693009392 DNA-binding site [nucleotide binding]; DNA binding site 545693009393 RNA-binding motif; other site 545693009394 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693009395 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693009396 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693009397 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 545693009398 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 545693009399 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 545693009400 dimerization interface [polypeptide binding]; other site 545693009401 putative active cleft [active] 545693009402 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693009403 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 545693009404 Cl binding site [ion binding]; other site 545693009405 oligomer interface [polypeptide binding]; other site 545693009406 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693009407 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 545693009408 oxidoreductase; Provisional; Region: PRK07985 545693009409 NAD binding site [chemical binding]; other site 545693009410 metal binding site [ion binding]; metal-binding site 545693009411 active site 545693009412 Heat induced stress protein YflT; Region: YflT; pfam11181 545693009413 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 545693009414 oxidoreductase; Provisional; Region: PRK06128 545693009415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009416 NAD(P) binding site [chemical binding]; other site 545693009417 active site 545693009418 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 545693009419 active site 545693009420 Zn binding site [ion binding]; other site 545693009421 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 545693009422 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 545693009423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693009424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009425 Coenzyme A binding pocket [chemical binding]; other site 545693009426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009427 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009428 putative substrate translocation pore; other site 545693009429 hypothetical protein; Provisional; Region: PRK08296 545693009430 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 545693009431 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 545693009432 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 545693009433 Na binding site [ion binding]; other site 545693009434 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693009435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009436 DNA-binding site [nucleotide binding]; DNA binding site 545693009437 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 545693009438 CAAX protease self-immunity; Region: Abi; pfam02517 545693009439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693009440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009441 Coenzyme A binding pocket [chemical binding]; other site 545693009442 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 545693009443 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693009444 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 545693009445 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 545693009446 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 545693009447 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693009448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693009449 active site 545693009450 motif I; other site 545693009451 motif II; other site 545693009452 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693009453 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 545693009454 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 545693009455 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 545693009456 dimerization interface [polypeptide binding]; other site 545693009457 ligand binding site [chemical binding]; other site 545693009458 NADP binding site [chemical binding]; other site 545693009459 catalytic site [active] 545693009460 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 545693009461 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 545693009462 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 545693009463 LysE type translocator; Region: LysE; cl00565 545693009464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693009465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009466 non-specific DNA binding site [nucleotide binding]; other site 545693009467 salt bridge; other site 545693009468 sequence-specific DNA binding site [nucleotide binding]; other site 545693009469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693009470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009471 Coenzyme A binding pocket [chemical binding]; other site 545693009472 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 545693009473 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 545693009474 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 545693009475 THF binding site; other site 545693009476 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 545693009477 substrate binding site [chemical binding]; other site 545693009478 THF binding site; other site 545693009479 zinc-binding site [ion binding]; other site 545693009480 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 545693009481 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693009482 active site 545693009483 metal binding site [ion binding]; metal-binding site 545693009484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009485 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 545693009486 putative substrate translocation pore; other site 545693009487 L-arabinose isomerase; Provisional; Region: PRK02929 545693009488 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 545693009489 hexamer (dimer of trimers) interface [polypeptide binding]; other site 545693009490 trimer interface [polypeptide binding]; other site 545693009491 substrate binding site [chemical binding]; other site 545693009492 Mn binding site [ion binding]; other site 545693009493 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 545693009494 intersubunit interface [polypeptide binding]; other site 545693009495 active site 545693009496 Zn2+ binding site [ion binding]; other site 545693009497 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 545693009498 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 545693009499 putative N- and C-terminal domain interface [polypeptide binding]; other site 545693009500 putative active site [active] 545693009501 MgATP binding site [chemical binding]; other site 545693009502 catalytic site [active] 545693009503 metal binding site [ion binding]; metal-binding site 545693009504 putative carbohydrate binding site [chemical binding]; other site 545693009505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009506 DNA-binding site [nucleotide binding]; DNA binding site 545693009507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693009508 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 545693009509 putative dimerization interface [polypeptide binding]; other site 545693009510 putative ligand binding site [chemical binding]; other site 545693009511 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 545693009512 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693009513 Zn2+ binding site [ion binding]; other site 545693009514 Mg2+ binding site [ion binding]; other site 545693009515 YtkA-like; Region: YtkA; pfam13115 545693009516 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 545693009517 Nucleoside recognition; Region: Gate; pfam07670 545693009518 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 545693009519 Nucleoside recognition; Region: Gate; pfam07670 545693009520 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 545693009521 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 545693009522 G1 box; other site 545693009523 GTP/Mg2+ binding site [chemical binding]; other site 545693009524 Switch I region; other site 545693009525 G2 box; other site 545693009526 G3 box; other site 545693009527 Switch II region; other site 545693009528 G4 box; other site 545693009529 G5 box; other site 545693009530 FeoA domain; Region: FeoA; pfam04023 545693009531 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 545693009532 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693009533 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 545693009534 dimer interface [polypeptide binding]; other site 545693009535 metal binding site [ion binding]; metal-binding site 545693009536 YtkA-like; Region: YtkA; pfam13115 545693009537 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693009538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693009539 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 545693009540 RNA polymerase factor sigma-70; Validated; Region: PRK06811 545693009541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693009542 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693009543 DNA binding residues [nucleotide binding] 545693009544 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 545693009545 putative dimer interface [polypeptide binding]; other site 545693009546 catalytic triad [active] 545693009547 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 545693009548 Protein of unknown function (DUF975); Region: DUF975; cl10504 545693009549 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693009550 EamA-like transporter family; Region: EamA; pfam00892 545693009551 EamA-like transporter family; Region: EamA; pfam00892 545693009552 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693009553 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693009554 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693009555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 545693009556 MOSC domain; Region: MOSC; pfam03473 545693009557 3-alpha domain; Region: 3-alpha; pfam03475 545693009558 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 545693009559 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 545693009560 Nucleoside recognition; Region: Gate; pfam07670 545693009561 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 545693009562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 545693009563 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 545693009564 active site 545693009565 DNA binding site [nucleotide binding] 545693009566 Int/Topo IB signature motif; other site 545693009567 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 545693009568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693009570 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 545693009571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693009572 catalytic residue [active] 545693009573 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693009574 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 545693009575 Putative cyclase; Region: Cyclase; cl00814 545693009576 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 545693009577 active site 1 [active] 545693009578 dimer interface [polypeptide binding]; other site 545693009579 hexamer interface [polypeptide binding]; other site 545693009580 active site 2 [active] 545693009581 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693009582 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 545693009583 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 545693009584 active site 545693009585 catalytic residues [active] 545693009586 metal binding site [ion binding]; metal-binding site 545693009587 DmpG-like communication domain; Region: DmpG_comm; pfam07836 545693009588 acetaldehyde dehydrogenase; Validated; Region: PRK08300 545693009589 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 545693009590 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 545693009591 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693009592 aldehyde dehydrogenase family 2 member; Region: PLN02466 545693009593 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 545693009594 NAD binding site [chemical binding]; other site 545693009595 catalytic residues [active] 545693009596 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 545693009597 homotrimer interaction site [polypeptide binding]; other site 545693009598 putative active site [active] 545693009599 Amidohydrolase; Region: Amidohydro_2; pfam04909 545693009600 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 545693009601 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 545693009602 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 545693009603 active site 545693009604 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 545693009605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693009606 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 545693009607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 545693009608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693009609 ligand binding site [chemical binding]; other site 545693009610 flexible hinge region; other site 545693009611 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 545693009612 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693009613 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 545693009614 ligand binding site [chemical binding]; other site 545693009615 flexible hinge region; other site 545693009616 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 545693009617 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 545693009618 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693009619 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693009620 DNA binding residues [nucleotide binding] 545693009621 putative dimer interface [polypeptide binding]; other site 545693009622 Domain of unknown function (DUF303); Region: DUF303; pfam03629 545693009623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693009624 binding surface 545693009625 TPR motif; other site 545693009626 Tetratrico peptide repeat; Region: TPR_5; pfam12688 545693009627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693009628 binding surface 545693009629 TPR motif; other site 545693009630 hypothetical protein; Provisional; Region: PRK07758 545693009631 A new structural DNA glycosylase; Region: AlkD_like; cd06561 545693009632 active site 545693009633 Uncharacterized conserved protein [Function unknown]; Region: COG5646 545693009634 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 545693009635 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 545693009636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 545693009637 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 545693009638 Probable transposase; Region: OrfB_IS605; pfam01385 545693009639 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 545693009640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 545693009641 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 545693009642 EamA-like transporter family; Region: EamA; pfam00892 545693009643 EamA-like transporter family; Region: EamA; pfam00892 545693009644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693009645 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 545693009646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009648 putative substrate translocation pore; other site 545693009649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693009651 salt bridge; other site 545693009652 non-specific DNA binding site [nucleotide binding]; other site 545693009653 sequence-specific DNA binding site [nucleotide binding]; other site 545693009654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 545693009655 nudix motif; other site 545693009656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009657 DinB family; Region: DinB; cl17821 545693009658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 545693009659 MOSC domain; Region: MOSC; pfam03473 545693009660 3-alpha domain; Region: 3-alpha; pfam03475 545693009661 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 545693009662 homotrimer interaction site [polypeptide binding]; other site 545693009663 putative active site [active] 545693009664 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009665 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693009666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009668 putative substrate translocation pore; other site 545693009669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009671 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 545693009672 putative dimerization interface [polypeptide binding]; other site 545693009673 Nitronate monooxygenase; Region: NMO; pfam03060 545693009674 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 545693009675 FMN binding site [chemical binding]; other site 545693009676 substrate binding site [chemical binding]; other site 545693009677 putative catalytic residue [active] 545693009678 glutamate racemase; Provisional; Region: PRK00865 545693009679 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693009680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693009681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009682 D-galactonate transporter; Region: 2A0114; TIGR00893 545693009683 putative substrate translocation pore; other site 545693009684 galactonate dehydratase; Provisional; Region: PRK14017 545693009685 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 545693009686 putative active site pocket [active] 545693009687 putative metal binding site [ion binding]; other site 545693009688 Entner-Doudoroff aldolase; Region: eda; TIGR01182 545693009689 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 545693009690 active site 545693009691 intersubunit interface [polypeptide binding]; other site 545693009692 catalytic residue [active] 545693009693 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693009694 substrate binding site [chemical binding]; other site 545693009695 ATP binding site [chemical binding]; other site 545693009696 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 545693009697 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693009698 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693009699 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693009700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009701 non-specific DNA binding site [nucleotide binding]; other site 545693009702 salt bridge; other site 545693009703 sequence-specific DNA binding site [nucleotide binding]; other site 545693009704 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 545693009705 ABC-2 type transporter; Region: ABC2_membrane; cl17235 545693009706 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693009707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693009708 Walker A/P-loop; other site 545693009709 ATP binding site [chemical binding]; other site 545693009710 Q-loop/lid; other site 545693009711 ABC transporter signature motif; other site 545693009712 Walker B; other site 545693009713 D-loop; other site 545693009714 H-loop/switch region; other site 545693009715 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 545693009716 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 545693009717 Predicted permeases [General function prediction only]; Region: COG0679 545693009718 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 545693009719 NAD(P) binding site [chemical binding]; other site 545693009720 catalytic residues [active] 545693009721 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693009722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009723 DNA-binding site [nucleotide binding]; DNA binding site 545693009724 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 545693009725 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 545693009726 hexamer (dimer of trimers) interface [polypeptide binding]; other site 545693009727 substrate binding site [chemical binding]; other site 545693009728 trimer interface [polypeptide binding]; other site 545693009729 Mn binding site [ion binding]; other site 545693009730 alpha-glucosidase; Provisional; Region: PRK10426 545693009731 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 545693009732 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 545693009733 putative active site [active] 545693009734 putative catalytic site [active] 545693009735 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693009736 active site 545693009737 intersubunit interactions; other site 545693009738 catalytic residue [active] 545693009739 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 545693009740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009741 putative substrate translocation pore; other site 545693009742 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693009743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009744 NAD(P) binding site [chemical binding]; other site 545693009745 active site 545693009746 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693009747 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 545693009748 putative NAD(P) binding site [chemical binding]; other site 545693009749 classical (c) SDRs; Region: SDR_c; cd05233 545693009750 short chain dehydrogenase; Region: adh_short; pfam00106 545693009751 NAD(P) binding site [chemical binding]; other site 545693009752 active site 545693009753 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009754 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693009755 TAP-like protein; Region: Abhydrolase_4; pfam08386 545693009756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693009758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693009759 dimerization interface [polypeptide binding]; other site 545693009760 putative DNA binding site [nucleotide binding]; other site 545693009761 putative Zn2+ binding site [ion binding]; other site 545693009762 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 545693009763 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 545693009764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693009765 ligand binding site [chemical binding]; other site 545693009766 flexible hinge region; other site 545693009767 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 545693009768 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693009769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009770 S-adenosylmethionine binding site [chemical binding]; other site 545693009771 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 545693009772 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 545693009773 active site 1 [active] 545693009774 dimer interface [polypeptide binding]; other site 545693009775 hexamer interface [polypeptide binding]; other site 545693009776 active site 2 [active] 545693009777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009780 dimerization interface [polypeptide binding]; other site 545693009781 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693009782 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 545693009783 conserved cys residue [active] 545693009784 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693009785 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 545693009786 putative DNA binding site [nucleotide binding]; other site 545693009787 putative Zn2+ binding site [ion binding]; other site 545693009788 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693009789 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693009790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009791 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693009792 TAP-like protein; Region: Abhydrolase_4; pfam08386 545693009793 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 545693009794 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 545693009795 catalytic triad [active] 545693009796 dimer interface [polypeptide binding]; other site 545693009797 conserved cis-peptide bond; other site 545693009798 Predicted flavoprotein [General function prediction only]; Region: COG0431 545693009799 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 545693009800 Zn binding site [ion binding]; other site 545693009801 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 545693009802 Zn binding site [ion binding]; other site 545693009803 Predicted membrane protein [Function unknown]; Region: COG2259 545693009804 malate dehydrogenase; Reviewed; Region: PRK06223 545693009805 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 545693009806 NAD(P) binding site [chemical binding]; other site 545693009807 dimer interface [polypeptide binding]; other site 545693009808 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693009809 substrate binding site [chemical binding]; other site 545693009810 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 545693009811 Hexamer interface [polypeptide binding]; other site 545693009812 Hexagonal pore residue; other site 545693009813 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 545693009814 Hexamer/Pentamer interface [polypeptide binding]; other site 545693009815 central pore; other site 545693009816 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 545693009817 Propanediol utilisation protein PduL; Region: PduL; pfam06130 545693009818 Propanediol utilisation protein PduL; Region: PduL; pfam06130 545693009819 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 545693009820 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 545693009821 Hexamer interface [polypeptide binding]; other site 545693009822 Hexagonal pore residue; other site 545693009823 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 545693009824 putative catalytic cysteine [active] 545693009825 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 545693009826 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 545693009827 Hexamer interface [polypeptide binding]; other site 545693009828 Hexagonal pore residue; other site 545693009829 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 545693009830 putative hexamer interface [polypeptide binding]; other site 545693009831 putative hexagonal pore; other site 545693009832 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 545693009833 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 545693009834 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 545693009835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693009836 nucleotide binding site [chemical binding]; other site 545693009837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693009838 nucleotide binding site [chemical binding]; other site 545693009839 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 545693009840 G1 box; other site 545693009841 GTP/Mg2+ binding site [chemical binding]; other site 545693009842 G2 box; other site 545693009843 Switch I region; other site 545693009844 G3 box; other site 545693009845 Switch II region; other site 545693009846 G4 box; other site 545693009847 G5 box; other site 545693009848 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 545693009849 putative hexamer interface [polypeptide binding]; other site 545693009850 putative hexagonal pore; other site 545693009851 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 545693009852 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 545693009853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693009854 active site 545693009855 phosphorylation site [posttranslational modification] 545693009856 intermolecular recognition site; other site 545693009857 dimerization interface [polypeptide binding]; other site 545693009858 ANTAR domain; Region: ANTAR; pfam03861 545693009859 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 545693009860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 545693009861 Histidine kinase; Region: HisKA_2; pfam07568 545693009862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693009863 ATP binding site [chemical binding]; other site 545693009864 Mg2+ binding site [ion binding]; other site 545693009865 G-X-G motif; other site 545693009866 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 545693009867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693009869 Transcriptional regulator, TetR, C-terminal; Region: TetR_C_9; pfam14514 545693009870 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 545693009871 benzoate transport; Region: 2A0115; TIGR00895 545693009872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009873 putative substrate translocation pore; other site 545693009874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693009875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693009876 DNA binding site [nucleotide binding] 545693009877 domain linker motif; other site 545693009878 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693009879 dimerization interface [polypeptide binding]; other site 545693009880 ligand binding site [chemical binding]; other site 545693009881 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 545693009882 inhibitor site; inhibition site 545693009883 active site 545693009884 dimer interface [polypeptide binding]; other site 545693009885 catalytic residue [active] 545693009886 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693009887 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 545693009888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009891 dimerization interface [polypeptide binding]; other site 545693009892 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 545693009893 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; cl19132 545693009894 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 545693009895 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 545693009896 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 545693009897 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693009898 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693009899 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693009900 putative active site [active] 545693009901 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 545693009902 Citrate transporter; Region: CitMHS; pfam03600 545693009903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009905 putative substrate translocation pore; other site 545693009906 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 545693009907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009908 putative substrate translocation pore; other site 545693009909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693009911 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 545693009912 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693009913 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693009914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 545693009915 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 545693009916 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 545693009917 substrate-cofactor binding pocket; other site 545693009918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693009919 catalytic residue [active] 545693009920 Protein of unknown function (DUF452); Region: DUF452; cl01062 545693009921 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009922 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 545693009923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009924 S-adenosylmethionine binding site [chemical binding]; other site 545693009925 Predicted transcriptional regulators [Transcription]; Region: COG1378 545693009926 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 545693009927 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 545693009928 C-terminal domain interface [polypeptide binding]; other site 545693009929 sugar binding site [chemical binding]; other site 545693009930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693009931 EamA-like transporter family; Region: EamA; pfam00892 545693009932 EamA-like transporter family; Region: EamA; pfam00892 545693009933 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 545693009934 active site 545693009935 metal binding site [ion binding]; metal-binding site 545693009936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009939 dimerization interface [polypeptide binding]; other site 545693009940 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 545693009941 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693009942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009943 Coenzyme A binding pocket [chemical binding]; other site 545693009944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693009945 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693009946 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 545693009947 conserved cys residue [active] 545693009948 CAAX protease self-immunity; Region: Abi; pfam02517 545693009949 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 545693009950 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 545693009951 active site 545693009952 homotetramer interface [polypeptide binding]; other site 545693009953 homodimer interface [polypeptide binding]; other site 545693009954 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 545693009955 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693009956 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693009957 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 545693009958 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693009959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693009961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009962 dimerization interface [polypeptide binding]; other site 545693009963 Uncharacterized conserved protein [Function unknown]; Region: COG4925 545693009964 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693009965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009966 putative substrate translocation pore; other site 545693009967 Heat induced stress protein YflT; Region: YflT; pfam11181 545693009968 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 545693009969 malate dehydrogenase; Provisional; Region: PRK13529 545693009970 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693009971 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 545693009972 NAD(P) binding site [chemical binding]; other site 545693009973 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 545693009974 DHH family; Region: DHH; pfam01368 545693009975 DinB superfamily; Region: DinB_2; pfam12867 545693009976 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 545693009977 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693009978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693009979 motif II; other site 545693009980 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693009981 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 545693009982 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 545693009983 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693009984 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693009985 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693009986 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693009987 potential frameshift: common BLAST hit: gi|150392276|ref|YP_001322325.1| membrane protein 545693009988 metal-dependent hydrolase; Provisional; Region: PRK13291 545693009989 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 545693009990 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 545693009991 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693009992 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693009993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009994 non-specific DNA binding site [nucleotide binding]; other site 545693009995 sequence-specific DNA binding site [nucleotide binding]; other site 545693009996 salt bridge; other site 545693009997 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 545693009998 SPW repeat; Region: SPW; pfam03779 545693009999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693010000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693010001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693010002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 545693010003 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693010004 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 545693010005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 545693010006 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 545693010007 Predicted transcriptional regulators [Transcription]; Region: COG1733 545693010008 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 545693010009 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693010010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693010011 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 545693010012 YvrJ protein family; Region: YvrJ; pfam12841 545693010013 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 545693010014 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 545693010015 dimer interface [polypeptide binding]; other site 545693010016 putative functional site; other site 545693010017 putative MPT binding site; other site 545693010018 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 545693010019 trimer interface [polypeptide binding]; other site 545693010020 dimer interface [polypeptide binding]; other site 545693010021 putative active site [active] 545693010022 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 545693010023 MPT binding site; other site 545693010024 trimer interface [polypeptide binding]; other site 545693010025 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 545693010026 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 545693010027 Moco binding site; other site 545693010028 metal coordination site [ion binding]; other site 545693010029 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693010030 TM-ABC transporter signature motif; other site 545693010031 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693010032 TM-ABC transporter signature motif; other site 545693010033 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 545693010034 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 545693010035 Walker A/P-loop; other site 545693010036 ATP binding site [chemical binding]; other site 545693010037 Q-loop/lid; other site 545693010038 ABC transporter signature motif; other site 545693010039 Walker B; other site 545693010040 D-loop; other site 545693010041 H-loop/switch region; other site 545693010042 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 545693010043 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 545693010044 ligand binding site [chemical binding]; other site 545693010045 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 545693010046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693010047 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 545693010048 PrpF protein; Region: PrpF; cl19418 545693010049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693010050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693010051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693010052 dimerization interface [polypeptide binding]; other site 545693010053 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 545693010054 Citrate transporter; Region: CitMHS; pfam03600 545693010055 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 545693010056 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 545693010057 oligomer interface [polypeptide binding]; other site 545693010058 active site residues [active] 545693010059 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693010060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693010061 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693010062 DNA binding residues [nucleotide binding] 545693010063 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 545693010064 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693010065 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693010066 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693010067 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693010068 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693010069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693010070 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693010071 putative substrate translocation pore; other site 545693010072 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693010073 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693010074 dimerization interface [polypeptide binding]; other site 545693010075 putative Zn2+ binding site [ion binding]; other site 545693010076 putative DNA binding site [nucleotide binding]; other site 545693010077 tegument protein UL16; Provisional; Region: PHA03351 545693010078 RNA polymerase factor sigma-70; Validated; Region: PRK08295 545693010079 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693010080 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693010081 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693010082 DNA-binding site [nucleotide binding]; DNA binding site 545693010083 RNA-binding motif; other site 545693010084 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; cl15694 545693010085 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693010086 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 545693010087 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 545693010088 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 545693010089 Glutamate binding site [chemical binding]; other site 545693010090 homodimer interface [polypeptide binding]; other site 545693010091 NAD binding site [chemical binding]; other site 545693010092 catalytic residues [active] 545693010093 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 545693010094 Proline dehydrogenase; Region: Pro_dh; pfam01619 545693010095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 545693010096 YcxB-like protein; Region: YcxB; pfam14317 545693010097 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 545693010098 dimer interface [polypeptide binding]; other site 545693010099 putative metal binding site [ion binding]; other site 545693010100 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 545693010101 stage II sporulation protein P; Region: spore_II_P; TIGR02867 545693010102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693010103 PAS domain; Region: PAS_9; pfam13426 545693010104 putative active site [active] 545693010105 heme pocket [chemical binding]; other site 545693010106 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693010107 metal binding site [ion binding]; metal-binding site 545693010108 active site 545693010109 I-site; other site 545693010110 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693010111 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 545693010112 putative active site [active] 545693010113 putative metal binding site [ion binding]; other site 545693010114 PgaD-like protein; Region: PgaD; cl14676 545693010115 N-glycosyltransferase; Provisional; Region: PRK11204 545693010116 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 545693010117 DXD motif; other site 545693010118 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 545693010119 Ferritin-like domain; Region: Ferritin; pfam00210 545693010120 ferroxidase diiron center [ion binding]; other site 545693010121 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693010122 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 545693010123 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693010124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693010125 S-adenosylmethionine binding site [chemical binding]; other site 545693010126 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 545693010127 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 545693010128 active site 545693010129 Zn binding site [ion binding]; other site 545693010130 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693010131 Phosphate-starvation-inducible E; Region: PsiE; cl01264 545693010132 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 545693010133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693010134 active site 545693010135 catalytic tetrad [active] 545693010136 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 545693010137 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 545693010138 DinB superfamily; Region: DinB_2; pfam12867 545693010139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693010140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010141 Coenzyme A binding pocket [chemical binding]; other site 545693010142 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 545693010143 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693010144 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693010145 DNA binding residues [nucleotide binding] 545693010146 putative dimer interface [polypeptide binding]; other site 545693010147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693010148 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 545693010149 active site 545693010150 catalytic tetrad [active] 545693010151 CAAX protease self-immunity; Region: Abi; pfam02517 545693010152 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693010153 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 545693010154 DNA binding residues [nucleotide binding] 545693010155 dimer interface [polypeptide binding]; other site 545693010156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693010157 putative substrate translocation pore; other site 545693010158 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693010159 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 545693010160 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693010161 substrate binding [chemical binding]; other site 545693010162 active site 545693010163 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693010164 YtxH-like protein; Region: YtxH; pfam12732 545693010165 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 545693010166 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 545693010167 active site 545693010168 nucleophile elbow; other site 545693010169 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 545693010170 FtsX-like permease family; Region: FtsX; pfam02687 545693010171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693010172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 545693010173 Walker A/P-loop; other site 545693010174 ATP binding site [chemical binding]; other site 545693010175 Q-loop/lid; other site 545693010176 ABC transporter signature motif; other site 545693010177 Walker B; other site 545693010178 D-loop; other site 545693010179 H-loop/switch region; other site 545693010180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693010181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010182 dimer interface [polypeptide binding]; other site 545693010183 phosphorylation site [posttranslational modification] 545693010184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010185 ATP binding site [chemical binding]; other site 545693010186 Mg2+ binding site [ion binding]; other site 545693010187 G-X-G motif; other site 545693010188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693010189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693010190 active site 545693010191 phosphorylation site [posttranslational modification] 545693010192 intermolecular recognition site; other site 545693010193 dimerization interface [polypeptide binding]; other site 545693010194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693010195 DNA binding site [nucleotide binding] 545693010196 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 545693010197 substrate binding pocket [chemical binding]; other site 545693010198 substrate-Mg2+ binding site; other site 545693010199 aspartate-rich region 1; other site 545693010200 aspartate-rich region 2; other site 545693010201 Predicted membrane protein [Function unknown]; Region: COG1289 545693010202 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 545693010203 Protein of unknown function (DUF964); Region: DUF964; cl01483 545693010204 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 545693010205 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 545693010206 putative homodimer interface [polypeptide binding]; other site 545693010207 putative homotetramer interface [polypeptide binding]; other site 545693010208 putative metal binding site [ion binding]; other site 545693010209 putative homodimer-homodimer interface [polypeptide binding]; other site 545693010210 putative allosteric switch controlling residues; other site 545693010211 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 545693010212 Competence protein J (ComJ); Region: ComJ; pfam11033 545693010213 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 545693010214 single-stranded DNA-binding protein; Region: PHA00458 545693010215 Part of AAA domain; Region: AAA_19; pfam13245 545693010216 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 545693010217 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 545693010218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693010219 substrate binding site [chemical binding]; other site 545693010220 oxyanion hole (OAH) forming residues; other site 545693010221 Predicted transcriptional regulators [Transcription]; Region: COG1733 545693010222 dimerization interface [polypeptide binding]; other site 545693010223 putative Zn2+ binding site [ion binding]; other site 545693010224 putative DNA binding site [nucleotide binding]; other site 545693010225 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 545693010226 CGNR zinc finger; Region: zf-CGNR; pfam11706 545693010227 HPP family; Region: HPP; pfam04982 545693010228 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 545693010229 Predicted membrane protein [Function unknown]; Region: COG2259 545693010230 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693010231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693010232 active site 545693010233 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 545693010234 active site 545693010235 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 545693010236 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 545693010237 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 545693010238 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 545693010239 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693010240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693010241 active site 545693010242 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693010243 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693010244 active site 545693010245 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 545693010246 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693010247 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693010248 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693010249 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 545693010250 heme-binding site [chemical binding]; other site 545693010251 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 545693010252 dimer interface [polypeptide binding]; other site 545693010253 putative CheW interface [polypeptide binding]; other site 545693010254 transcriptional regulator Hpr; Provisional; Region: PRK13777 545693010255 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693010256 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 545693010257 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693010258 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 545693010259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693010260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693010261 DNA binding residues [nucleotide binding] 545693010262 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693010263 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693010264 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 545693010265 NodB motif; other site 545693010266 active site 545693010267 catalytic site [active] 545693010268 Spore germination protein; Region: Spore_permease; cl17796 545693010269 flagellar assembly protein H; Validated; Region: fliH; PRK05687 545693010270 S-methylmethionine transporter; Provisional; Region: PRK11387 545693010271 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693010272 Arginase family; Region: Arginase; cd09989 545693010273 active site 545693010274 oligomer interface [polypeptide binding]; other site 545693010275 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 545693010276 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 545693010277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693010278 TPR motif; other site 545693010279 binding surface 545693010280 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 545693010281 Cation transport protein; Region: TrkH; cl17365 545693010282 Cation transport protein; Region: TrkH; pfam02386 545693010283 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 545693010284 TrkA-N domain; Region: TrkA_N; pfam02254 545693010285 TrkA-C domain; Region: TrkA_C; pfam02080 545693010286 Uncharacterized conserved protein [Function unknown]; Region: COG2128 545693010287 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693010288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693010289 putative DNA binding site [nucleotide binding]; other site 545693010290 putative Zn2+ binding site [ion binding]; other site 545693010291 AsnC family; Region: AsnC_trans_reg; pfam01037 545693010292 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 545693010293 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 545693010294 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 545693010295 protein binding site [polypeptide binding]; other site 545693010296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693010297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693010298 active site 545693010299 phosphorylation site [posttranslational modification] 545693010300 intermolecular recognition site; other site 545693010301 dimerization interface [polypeptide binding]; other site 545693010302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693010303 DNA binding site [nucleotide binding] 545693010304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693010305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693010306 dimerization interface [polypeptide binding]; other site 545693010307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010308 dimer interface [polypeptide binding]; other site 545693010309 phosphorylation site [posttranslational modification] 545693010310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010311 ATP binding site [chemical binding]; other site 545693010312 Mg2+ binding site [ion binding]; other site 545693010313 G-X-G motif; other site 545693010314 D-cysteine desulfhydrase; Validated; Region: PRK03910 545693010315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693010316 catalytic residue [active] 545693010317 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 545693010318 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 545693010319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693010320 DNA-binding site [nucleotide binding]; DNA binding site 545693010321 FCD domain; Region: FCD; pfam07729 545693010322 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 545693010323 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 545693010324 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 545693010325 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 545693010326 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 545693010327 active site 545693010328 Transcriptional regulator [Transcription]; Region: LytR; COG1316 545693010329 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693010330 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 545693010331 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693010332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693010333 dimer interface [polypeptide binding]; other site 545693010334 conserved gate region; other site 545693010335 ABC-ATPase subunit interface; other site 545693010336 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 545693010337 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 545693010338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693010339 Walker A/P-loop; other site 545693010340 ATP binding site [chemical binding]; other site 545693010341 Q-loop/lid; other site 545693010342 ABC transporter signature motif; other site 545693010343 Walker B; other site 545693010344 D-loop; other site 545693010345 H-loop/switch region; other site 545693010346 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 545693010347 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 545693010348 iron-sulfur cluster [ion binding]; other site 545693010349 [2Fe-2S] cluster binding site [ion binding]; other site 545693010350 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 545693010351 hydrophobic ligand binding site; other site 545693010352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693010353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693010354 putative substrate translocation pore; other site 545693010355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693010356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693010357 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693010358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693010359 dimer interface [polypeptide binding]; other site 545693010360 conserved gate region; other site 545693010361 putative PBP binding loops; other site 545693010362 ABC-ATPase subunit interface; other site 545693010363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693010364 putative PBP binding loops; other site 545693010365 ABC-ATPase subunit interface; other site 545693010366 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693010367 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 545693010368 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 545693010369 N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742 545693010370 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 545693010371 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693010372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693010373 DNA binding site [nucleotide binding] 545693010374 domain linker motif; other site 545693010375 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693010376 dimerization interface [polypeptide binding]; other site 545693010377 ligand binding site [chemical binding]; other site 545693010378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693010379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010380 dimer interface [polypeptide binding]; other site 545693010381 phosphorylation site [posttranslational modification] 545693010382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010383 ATP binding site [chemical binding]; other site 545693010384 Mg2+ binding site [ion binding]; other site 545693010385 G-X-G motif; other site 545693010386 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693010387 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693010388 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 545693010389 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 545693010390 FMN binding site [chemical binding]; other site 545693010391 substrate binding site [chemical binding]; other site 545693010392 putative catalytic residue [active] 545693010393 hydroperoxidase II; Provisional; Region: katE; PRK11249 545693010394 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 545693010395 tetramer interface [polypeptide binding]; other site 545693010396 heme binding pocket [chemical binding]; other site 545693010397 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 545693010398 domain interactions; other site 545693010399 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 545693010400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693010401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010402 Coenzyme A binding pocket [chemical binding]; other site 545693010403 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693010404 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693010405 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693010406 Transcriptional regulator [Transcription]; Region: LytR; COG1316 545693010407 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693010408 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693010409 Sulfatase; Region: Sulfatase; pfam00884 545693010410 Cupin domain; Region: Cupin_2; pfam07883 545693010411 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693010412 EamA-like transporter family; Region: EamA; pfam00892 545693010413 EamA-like transporter family; Region: EamA; pfam00892 545693010414 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 545693010415 putative active site [active] 545693010416 putative FMN binding site [chemical binding]; other site 545693010417 putative substrate binding site [chemical binding]; other site 545693010418 putative catalytic residue [active] 545693010419 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693010420 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 545693010421 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693010422 Predicted integral membrane protein [Function unknown]; Region: COG5505 545693010423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693010424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693010425 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 545693010426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693010427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693010428 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693010429 putative dimerization interface [polypeptide binding]; other site 545693010430 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693010431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693010432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010433 Coenzyme A binding pocket [chemical binding]; other site 545693010434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693010435 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693010436 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 545693010437 NAD binding site [chemical binding]; other site 545693010438 substrate binding site [chemical binding]; other site 545693010439 putative active site [active] 545693010440 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 545693010441 MgtC family; Region: MgtC; pfam02308 545693010442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693010443 S-adenosylmethionine binding site [chemical binding]; other site 545693010444 Protein of unknown function (DUF867); Region: DUF867; pfam05908 545693010445 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693010446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693010447 DNA-binding site [nucleotide binding]; DNA binding site 545693010448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693010449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010450 homodimer interface [polypeptide binding]; other site 545693010451 catalytic residue [active] 545693010452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693010454 Coenzyme A binding pocket [chemical binding]; other site 545693010455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010456 Coenzyme A binding pocket [chemical binding]; other site 545693010457 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693010458 Spore germination protein; Region: Spore_permease; cl17796 545693010459 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693010460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010461 Coenzyme A binding pocket [chemical binding]; other site 545693010462 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 545693010463 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 545693010464 Ligand binding site; other site 545693010465 Putative Catalytic site; other site 545693010466 DXD motif; other site 545693010467 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693010468 GtrA-like protein; Region: GtrA; pfam04138 545693010469 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 545693010470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693010471 active site 545693010472 metal binding site [ion binding]; metal-binding site 545693010473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 545693010474 protoporphyrinogen oxidase; Provisional; Region: PRK12416 545693010475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 545693010476 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 545693010477 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 545693010478 putative metal binding site [ion binding]; other site 545693010479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693010480 active site 545693010481 metal binding site [ion binding]; metal-binding site 545693010482 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693010483 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693010484 EamA-like transporter family; Region: EamA; pfam00892 545693010485 EamA-like transporter family; Region: EamA; pfam00892 545693010486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010487 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693010488 Coenzyme A binding pocket [chemical binding]; other site 545693010489 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 545693010490 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 545693010491 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 545693010492 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 545693010493 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693010494 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693010495 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 545693010496 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 545693010497 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693010498 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693010499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693010500 Transporter associated domain; Region: CorC_HlyC; smart01091 545693010501 NAD-dependent deacetylase; Provisional; Region: PRK00481 545693010502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693010503 Ligand Binding Site [chemical binding]; other site 545693010504 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 545693010505 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 545693010506 active site 545693010507 ADP/pyrophosphate binding site [chemical binding]; other site 545693010508 dimerization interface [polypeptide binding]; other site 545693010509 allosteric effector site; other site 545693010510 fructose-1,6-bisphosphate binding site; other site 545693010511 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693010512 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 545693010513 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693010514 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 545693010515 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 545693010516 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693010517 Spore germination protein; Region: Spore_permease; cl17796 545693010518 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 545693010519 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 545693010520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693010521 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693010522 Walker A/P-loop; other site 545693010523 ATP binding site [chemical binding]; other site 545693010524 Q-loop/lid; other site 545693010525 ABC transporter signature motif; other site 545693010526 Walker B; other site 545693010527 D-loop; other site 545693010528 H-loop/switch region; other site 545693010529 Predicted transcriptional regulators [Transcription]; Region: COG1725 545693010530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693010531 DNA-binding site [nucleotide binding]; DNA binding site 545693010532 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693010533 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693010534 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693010535 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693010536 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 545693010537 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010538 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010539 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 545693010540 active site 545693010541 putative catalytic site [active] 545693010542 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 545693010543 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693010544 active site 545693010545 catalytic site [active] 545693010546 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 545693010547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693010548 Walker A/P-loop; other site 545693010549 ATP binding site [chemical binding]; other site 545693010550 Q-loop/lid; other site 545693010551 ABC transporter signature motif; other site 545693010552 Walker B; other site 545693010553 D-loop; other site 545693010554 H-loop/switch region; other site 545693010555 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693010556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693010557 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 545693010558 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 545693010559 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 545693010560 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693010561 active site turn [active] 545693010562 phosphorylation site [posttranslational modification] 545693010563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693010564 transcriptional antiterminator BglG; Provisional; Region: PRK09772 545693010565 CAT RNA binding domain; Region: CAT_RBD; smart01061 545693010566 PRD domain; Region: PRD; pfam00874 545693010567 PRD domain; Region: PRD; pfam00874 545693010568 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 545693010569 HPr interaction site; other site 545693010570 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693010571 active site 545693010572 phosphorylation site [posttranslational modification] 545693010573 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 545693010574 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 545693010575 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 545693010576 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 545693010577 Sulfate transporter family; Region: Sulfate_transp; pfam00916 545693010578 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 545693010579 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 545693010580 YodL-like; Region: YodL; pfam14191 545693010581 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 545693010582 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693010583 active site 545693010584 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 545693010585 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 545693010586 Catalytic domain of Protein Kinases; Region: PKc; cd00180 545693010587 active site 545693010588 ATP binding site [chemical binding]; other site 545693010589 substrate binding site [chemical binding]; other site 545693010590 activation loop (A-loop); other site 545693010591 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 545693010592 YozD-like protein; Region: YozD; pfam14162 545693010593 hypothetical protein; Provisional; Region: PRK13672 545693010594 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 545693010595 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 545693010596 homodimer interface [polypeptide binding]; other site 545693010597 substrate-cofactor binding pocket; other site 545693010598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010599 catalytic residue [active] 545693010600 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 545693010601 toxin interface [polypeptide binding]; other site 545693010602 Zn binding site [ion binding]; other site 545693010603 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 545693010604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693010605 FeS/SAM binding site; other site 545693010606 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 545693010607 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 545693010608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693010609 Coenzyme A binding pocket [chemical binding]; other site 545693010610 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 545693010611 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 545693010612 metal binding site [ion binding]; metal-binding site 545693010613 dimer interface [polypeptide binding]; other site 545693010614 Coenzyme A transferase; Region: CoA_trans; cl17247 545693010615 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 545693010616 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693010617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693010618 inhibitor-cofactor binding pocket; inhibition site 545693010619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010620 catalytic residue [active] 545693010621 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 545693010622 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 545693010623 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693010624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693010625 putative active site [active] 545693010626 heme pocket [chemical binding]; other site 545693010627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010628 dimer interface [polypeptide binding]; other site 545693010629 phosphorylation site [posttranslational modification] 545693010630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010631 ATP binding site [chemical binding]; other site 545693010632 Mg2+ binding site [ion binding]; other site 545693010633 G-X-G motif; other site 545693010634 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010635 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010636 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 545693010637 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 545693010638 active site 545693010639 catalytic triad [active] 545693010640 oxyanion hole [active] 545693010641 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 545693010642 Cu(I) binding site [ion binding]; other site 545693010643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693010644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693010645 dimerization interface [polypeptide binding]; other site 545693010646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010647 dimer interface [polypeptide binding]; other site 545693010648 phosphorylation site [posttranslational modification] 545693010649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010650 ATP binding site [chemical binding]; other site 545693010651 Mg2+ binding site [ion binding]; other site 545693010652 G-X-G motif; other site 545693010653 EDD domain protein, DegV family; Region: DegV; TIGR00762 545693010654 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 545693010655 threonine dehydratase; Validated; Region: PRK08639 545693010656 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 545693010657 tetramer interface [polypeptide binding]; other site 545693010658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010659 catalytic residue [active] 545693010660 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 545693010661 putative Ile/Val binding site [chemical binding]; other site 545693010662 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 545693010663 folate binding site [chemical binding]; other site 545693010664 NADP+ binding site [chemical binding]; other site 545693010665 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 545693010666 dimerization interface [polypeptide binding]; other site 545693010667 active site 545693010668 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 545693010669 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 545693010670 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 545693010671 putative active site [active] 545693010672 putative substrate binding site [chemical binding]; other site 545693010673 putative cosubstrate binding site; other site 545693010674 catalytic site [active] 545693010675 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 545693010676 IucA / IucC family; Region: IucA_IucC; pfam04183 545693010677 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 545693010678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693010679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693010680 putative substrate translocation pore; other site 545693010681 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 545693010682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693010683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 545693010684 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 545693010685 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 545693010686 IucA / IucC family; Region: IucA_IucC; pfam04183 545693010687 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 545693010688 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 545693010689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010690 catalytic residue [active] 545693010691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693010692 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693010693 inhibitor-cofactor binding pocket; inhibition site 545693010694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010695 catalytic residue [active] 545693010696 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 545693010697 Forkhead N-terminal region; Region: Fork_head_N; pfam08430 545693010698 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 545693010699 DNA photolyase; Region: DNA_photolyase; pfam00875 545693010700 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 545693010701 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693010702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693010703 putative active site [active] 545693010704 heme pocket [chemical binding]; other site 545693010705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010706 dimer interface [polypeptide binding]; other site 545693010707 phosphorylation site [posttranslational modification] 545693010708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010709 ATP binding site [chemical binding]; other site 545693010710 Mg2+ binding site [ion binding]; other site 545693010711 G-X-G motif; other site 545693010712 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 545693010713 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 545693010714 tetramerization interface [polypeptide binding]; other site 545693010715 NAD(P) binding site [chemical binding]; other site 545693010716 catalytic residues [active] 545693010717 PAS domain; Region: PAS_9; pfam13426 545693010718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693010719 putative active site [active] 545693010720 heme pocket [chemical binding]; other site 545693010721 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693010722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693010723 Walker A motif; other site 545693010724 ATP binding site [chemical binding]; other site 545693010725 Walker B motif; other site 545693010726 arginine finger; other site 545693010727 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 545693010728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693010729 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693010730 inhibitor-cofactor binding pocket; inhibition site 545693010731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010732 catalytic residue [active] 545693010733 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 545693010734 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 545693010735 hypothetical protein; Provisional; Region: PRK04164 545693010736 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 545693010737 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 545693010738 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693010739 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 545693010740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693010741 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 545693010742 Walker A/P-loop; other site 545693010743 ATP binding site [chemical binding]; other site 545693010744 Q-loop/lid; other site 545693010745 ABC transporter signature motif; other site 545693010746 Walker B; other site 545693010747 D-loop; other site 545693010748 H-loop/switch region; other site 545693010749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693010750 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 545693010751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693010752 Walker A/P-loop; other site 545693010753 ATP binding site [chemical binding]; other site 545693010754 Q-loop/lid; other site 545693010755 ABC transporter signature motif; other site 545693010756 Walker B; other site 545693010757 D-loop; other site 545693010758 H-loop/switch region; other site 545693010759 hypothetical protein; Provisional; Region: PRK01844 545693010760 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 545693010761 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 545693010762 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 545693010763 TPP-binding site [chemical binding]; other site 545693010764 dimer interface [polypeptide binding]; other site 545693010765 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693010766 PYR/PP interface [polypeptide binding]; other site 545693010767 dimer interface [polypeptide binding]; other site 545693010768 TPP binding site [chemical binding]; other site 545693010769 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693010770 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 545693010771 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 545693010772 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 545693010773 catalytic residues [active] 545693010774 catalytic nucleophile [active] 545693010775 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693010776 LexA repressor; Validated; Region: PRK00215 545693010777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693010778 putative DNA binding site [nucleotide binding]; other site 545693010779 putative Zn2+ binding site [ion binding]; other site 545693010780 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 545693010781 Catalytic site [active] 545693010782 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 545693010783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693010784 UreI/AmiS family, proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like; cl03519 545693010785 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 545693010786 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 545693010787 K+ potassium transporter; Region: K_trans; cl15781 545693010788 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693010789 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693010790 active site 545693010791 metal binding site [ion binding]; metal-binding site 545693010792 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693010793 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693010794 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693010795 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 545693010796 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 545693010797 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 545693010798 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 545693010799 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693010800 DNA binding residues [nucleotide binding] 545693010801 putative dimer interface [polypeptide binding]; other site 545693010802 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 545693010803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693010804 catalytic residue [active] 545693010805 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 545693010806 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 545693010807 HflX GTPase family; Region: HflX; cd01878 545693010808 G1 box; other site 545693010809 GTP/Mg2+ binding site [chemical binding]; other site 545693010810 Switch I region; other site 545693010811 G2 box; other site 545693010812 G3 box; other site 545693010813 Switch II region; other site 545693010814 G4 box; other site 545693010815 G5 box; other site 545693010816 Predicted membrane protein [Function unknown]; Region: COG2860 545693010817 UPF0126 domain; Region: UPF0126; pfam03458 545693010818 UPF0126 domain; Region: UPF0126; pfam03458 545693010819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693010820 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 545693010821 Walker A motif; other site 545693010822 ATP binding site [chemical binding]; other site 545693010823 Walker B motif; other site 545693010824 arginine finger; other site 545693010825 bacterial Hfq-like; Region: Hfq; cd01716 545693010826 hexamer interface [polypeptide binding]; other site 545693010827 Sm1 motif; other site 545693010828 RNA binding site [nucleotide binding]; other site 545693010829 Sm2 motif; other site 545693010830 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 545693010831 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 545693010832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010833 ATP binding site [chemical binding]; other site 545693010834 Mg2+ binding site [ion binding]; other site 545693010835 G-X-G motif; other site 545693010836 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 545693010837 ATP binding site [chemical binding]; other site 545693010838 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 545693010839 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 545693010840 MutS domain I; Region: MutS_I; pfam01624 545693010841 MutS domain II; Region: MutS_II; pfam05188 545693010842 MutS domain III; Region: MutS_III; pfam05192 545693010843 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 545693010844 Walker A/P-loop; other site 545693010845 ATP binding site [chemical binding]; other site 545693010846 Q-loop/lid; other site 545693010847 ABC transporter signature motif; other site 545693010848 Walker B; other site 545693010849 D-loop; other site 545693010850 H-loop/switch region; other site 545693010851 amino acid transporter; Region: 2A0306; TIGR00909 545693010852 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 545693010853 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 545693010854 Outer spore coat protein E (CotE); Region: CotE; pfam10628 545693010855 Predicted membrane protein [Function unknown]; Region: COG4550 545693010856 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 545693010857 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 545693010858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693010859 FeS/SAM binding site; other site 545693010860 TRAM domain; Region: TRAM; pfam01938 545693010861 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 545693010862 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 545693010863 TPP-binding site [chemical binding]; other site 545693010864 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 545693010865 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 545693010866 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 545693010867 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 545693010868 dimer interface [polypeptide binding]; other site 545693010869 PYR/PP interface [polypeptide binding]; other site 545693010870 TPP binding site [chemical binding]; other site 545693010871 substrate binding site [chemical binding]; other site 545693010872 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693010873 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 545693010874 active site 545693010875 dimer interface [polypeptide binding]; other site 545693010876 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 545693010877 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 545693010878 putative active site [active] 545693010879 metal binding site [ion binding]; metal-binding site 545693010880 homodimer binding site [polypeptide binding]; other site 545693010881 phosphodiesterase; Provisional; Region: PRK12704 545693010882 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693010883 Uncharacterized conserved protein [Function unknown]; Region: COG3334 545693010884 KH domain; Region: KH_1; pfam00013 545693010885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693010886 Zn2+ binding site [ion binding]; other site 545693010887 Mg2+ binding site [ion binding]; other site 545693010888 recombinase A; Provisional; Region: recA; PRK09354 545693010889 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 545693010890 hexamer interface [polypeptide binding]; other site 545693010891 Walker A motif; other site 545693010892 ATP binding site [chemical binding]; other site 545693010893 Walker B motif; other site 545693010894 competence damage-inducible protein A; Provisional; Region: PRK00549 545693010895 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 545693010896 putative MPT binding site; other site 545693010897 Competence-damaged protein; Region: CinA; pfam02464 545693010898 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 545693010899 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 545693010900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693010901 non-specific DNA binding site [nucleotide binding]; other site 545693010902 salt bridge; other site 545693010903 sequence-specific DNA binding site [nucleotide binding]; other site 545693010904 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 545693010905 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 545693010906 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 545693010907 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693010908 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693010909 classical (c) SDRs; Region: SDR_c; cd05233 545693010910 NAD(P) binding site [chemical binding]; other site 545693010911 active site 545693010912 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 545693010913 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 545693010914 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 545693010915 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 545693010916 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 545693010917 Vps23 core domain; Region: Vps23_core; pfam09454 545693010918 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693010919 TM-ABC transporter signature motif; other site 545693010920 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693010921 TM-ABC transporter signature motif; other site 545693010922 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 545693010923 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 545693010924 Walker A/P-loop; other site 545693010925 ATP binding site [chemical binding]; other site 545693010926 Q-loop/lid; other site 545693010927 ABC transporter signature motif; other site 545693010928 Walker B; other site 545693010929 D-loop; other site 545693010930 H-loop/switch region; other site 545693010931 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 545693010932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 545693010933 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 545693010934 ligand binding site [chemical binding]; other site 545693010935 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693010936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693010937 DNA-binding site [nucleotide binding]; DNA binding site 545693010938 UTRA domain; Region: UTRA; pfam07702 545693010939 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 545693010940 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 545693010941 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693010942 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 545693010943 YlzJ-like protein; Region: YlzJ; pfam14035 545693010944 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 545693010945 active site 545693010946 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 545693010947 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693010948 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 545693010949 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 545693010950 dimer interface [polypeptide binding]; other site 545693010951 active site 545693010952 catalytic residue [active] 545693010953 aspartate kinase I; Reviewed; Region: PRK08210 545693010954 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 545693010955 nucleotide binding site [chemical binding]; other site 545693010956 substrate binding site [chemical binding]; other site 545693010957 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 545693010958 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 545693010959 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 545693010960 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 545693010961 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 545693010962 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 545693010963 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 545693010964 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 545693010965 NAD binding site [chemical binding]; other site 545693010966 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 545693010967 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 545693010968 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 545693010969 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 545693010970 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 545693010971 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 545693010972 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 545693010973 NodB motif; other site 545693010974 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 545693010975 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 545693010976 RNase E interface [polypeptide binding]; other site 545693010977 trimer interface [polypeptide binding]; other site 545693010978 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 545693010979 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 545693010980 RNase E interface [polypeptide binding]; other site 545693010981 trimer interface [polypeptide binding]; other site 545693010982 active site 545693010983 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 545693010984 putative nucleic acid binding region [nucleotide binding]; other site 545693010985 G-X-X-G motif; other site 545693010986 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 545693010987 RNA binding site [nucleotide binding]; other site 545693010988 domain interface; other site 545693010989 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 545693010990 16S/18S rRNA binding site [nucleotide binding]; other site 545693010991 S13e-L30e interaction site [polypeptide binding]; other site 545693010992 25S rRNA binding site [nucleotide binding]; other site 545693010993 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 545693010994 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 545693010995 active site 545693010996 Riboflavin kinase; Region: Flavokinase; smart00904 545693010997 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 545693010998 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 545693010999 RNA binding site [nucleotide binding]; other site 545693011000 active site 545693011001 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 545693011002 Protein of unknown function (DUF503); Region: DUF503; cl00669 545693011003 translation initiation factor IF-2; Region: IF-2; TIGR00487 545693011004 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 545693011005 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 545693011006 G1 box; other site 545693011007 putative GEF interaction site [polypeptide binding]; other site 545693011008 GTP/Mg2+ binding site [chemical binding]; other site 545693011009 Switch I region; other site 545693011010 G2 box; other site 545693011011 G3 box; other site 545693011012 Switch II region; other site 545693011013 G4 box; other site 545693011014 G5 box; other site 545693011015 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 545693011016 Translation-initiation factor 2; Region: IF-2; pfam11987 545693011017 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 545693011018 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 545693011019 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 545693011020 putative RNA binding cleft [nucleotide binding]; other site 545693011021 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 545693011022 NusA N-terminal domain; Region: NusA_N; pfam08529 545693011023 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 545693011024 RNA binding site [nucleotide binding]; other site 545693011025 homodimer interface [polypeptide binding]; other site 545693011026 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 545693011027 G-X-X-G motif; other site 545693011028 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 545693011029 G-X-X-G motif; other site 545693011030 hypothetical protein; Provisional; Region: PRK14641 545693011031 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 545693011032 putative oligomer interface [polypeptide binding]; other site 545693011033 putative RNA binding site [nucleotide binding]; other site 545693011034 DNA polymerase III PolC; Validated; Region: polC; PRK00448 545693011035 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 545693011036 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 545693011037 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 545693011038 generic binding surface II; other site 545693011039 generic binding surface I; other site 545693011040 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 545693011041 active site 545693011042 putative PHP Thumb interface [polypeptide binding]; other site 545693011043 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 545693011044 active site 545693011045 catalytic site [active] 545693011046 substrate binding site [chemical binding]; other site 545693011047 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 545693011048 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 545693011049 prolyl-tRNA synthetase; Provisional; Region: PRK09194 545693011050 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 545693011051 dimer interface [polypeptide binding]; other site 545693011052 motif 1; other site 545693011053 active site 545693011054 motif 2; other site 545693011055 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 545693011056 putative deacylase active site [active] 545693011057 motif 3; other site 545693011058 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 545693011059 anticodon binding site; other site 545693011060 RIP metalloprotease RseP; Region: TIGR00054 545693011061 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 545693011062 active site 545693011063 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 545693011064 protein binding site [polypeptide binding]; other site 545693011065 putative substrate binding region [chemical binding]; other site 545693011066 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 545693011067 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 545693011068 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 545693011069 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 545693011070 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 545693011071 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 545693011072 active site 545693011073 dimer interface [polypeptide binding]; other site 545693011074 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 545693011075 hinge region; other site 545693011076 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 545693011077 putative nucleotide binding site [chemical binding]; other site 545693011078 uridine monophosphate binding site [chemical binding]; other site 545693011079 homohexameric interface [polypeptide binding]; other site 545693011080 elongation factor Ts; Provisional; Region: tsf; PRK09377 545693011081 UBA/TS-N domain; Region: UBA; pfam00627 545693011082 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 545693011083 rRNA interaction site [nucleotide binding]; other site 545693011084 S8 interaction site; other site 545693011085 putative laminin-1 binding site; other site 545693011086 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 545693011087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011088 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693011089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011090 DNA binding residues [nucleotide binding] 545693011091 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 545693011092 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 545693011093 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 545693011094 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 545693011095 putative binding surface; other site 545693011096 active site 545693011097 P2 response regulator binding domain; Region: P2; pfam07194 545693011098 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 545693011099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693011100 ATP binding site [chemical binding]; other site 545693011101 Mg2+ binding site [ion binding]; other site 545693011102 G-X-G motif; other site 545693011103 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 545693011104 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 545693011105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693011106 active site 545693011107 phosphorylation site [posttranslational modification] 545693011108 intermolecular recognition site; other site 545693011109 dimerization interface [polypeptide binding]; other site 545693011110 CheB methylesterase; Region: CheB_methylest; pfam01339 545693011111 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 545693011112 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 545693011113 P-loop; other site 545693011114 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 545693011115 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 545693011116 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 545693011117 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 545693011118 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 545693011119 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 545693011120 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 545693011121 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 545693011122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693011123 active site 545693011124 phosphorylation site [posttranslational modification] 545693011125 intermolecular recognition site; other site 545693011126 dimerization interface [polypeptide binding]; other site 545693011127 flagellar motor switch protein; Validated; Region: PRK08119 545693011128 CheC-like family; Region: CheC; pfam04509 545693011129 CheC-like family; Region: CheC; pfam04509 545693011130 flagellar motor switch protein FliN; Region: fliN; TIGR02480 545693011131 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 545693011132 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 545693011133 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 545693011134 Flagellar protein (FlbD); Region: FlbD; pfam06289 545693011135 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 545693011136 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 545693011137 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 545693011138 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 545693011139 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 545693011140 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 545693011141 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 545693011142 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 545693011143 Uncharacterized conserved protein [Function unknown]; Region: COG3334 545693011144 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 545693011145 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 545693011146 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 545693011147 Walker A motif/ATP binding site; other site 545693011148 Walker B motif; other site 545693011149 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 545693011150 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 545693011151 FliG N-terminal domain; Region: FliG_N; pfam14842 545693011152 FliG middle domain; Region: FliG_M; pfam14841 545693011153 FliG C-terminal domain; Region: FliG_C; pfam01706 545693011154 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 545693011155 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 545693011156 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 545693011157 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 545693011158 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 545693011159 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 545693011160 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 545693011161 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 545693011162 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 545693011163 transcriptional repressor CodY; Validated; Region: PRK04158 545693011164 CodY GAF-like domain; Region: CodY; pfam06018 545693011165 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 545693011166 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 545693011167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693011168 Walker A motif; other site 545693011169 ATP binding site [chemical binding]; other site 545693011170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693011171 Walker B motif; other site 545693011172 arginine finger; other site 545693011173 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 545693011174 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 545693011175 active site 545693011176 HslU subunit interaction site [polypeptide binding]; other site 545693011177 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 545693011178 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 545693011179 active site 545693011180 DNA binding site [nucleotide binding] 545693011181 Int/Topo IB signature motif; other site 545693011182 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 545693011183 Glucose inhibited division protein A; Region: GIDA; pfam01134 545693011184 DNA topoisomerase I; Validated; Region: PRK05582 545693011185 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 545693011186 active site 545693011187 interdomain interaction site; other site 545693011188 putative metal-binding site [ion binding]; other site 545693011189 nucleotide binding site [chemical binding]; other site 545693011190 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693011191 domain I; other site 545693011192 DNA binding groove [nucleotide binding] 545693011193 phosphate binding site [ion binding]; other site 545693011194 domain II; other site 545693011195 domain III; other site 545693011196 nucleotide binding site [chemical binding]; other site 545693011197 catalytic site [active] 545693011198 domain IV; other site 545693011199 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 545693011200 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 545693011201 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 545693011202 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 545693011203 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 545693011204 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 545693011205 CoA binding domain; Region: CoA_binding; pfam02629 545693011206 CoA-ligase; Region: Ligase_CoA; pfam00549 545693011207 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 545693011208 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 545693011209 CoA-ligase; Region: Ligase_CoA; pfam00549 545693011210 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 545693011211 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693011212 active site 545693011213 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 545693011214 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 545693011215 GTP/Mg2+ binding site [chemical binding]; other site 545693011216 G4 box; other site 545693011217 G5 box; other site 545693011218 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 545693011219 G1 box; other site 545693011220 G1 box; other site 545693011221 GTP/Mg2+ binding site [chemical binding]; other site 545693011222 Switch I region; other site 545693011223 G2 box; other site 545693011224 G2 box; other site 545693011225 Switch I region; other site 545693011226 G3 box; other site 545693011227 G3 box; other site 545693011228 Switch II region; other site 545693011229 Switch II region; other site 545693011230 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693011231 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693011232 Catalytic site [active] 545693011233 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 545693011234 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 545693011235 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 545693011236 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 545693011237 RimM N-terminal domain; Region: RimM; pfam01782 545693011238 PRC-barrel domain; Region: PRC; pfam05239 545693011239 YlqD protein; Region: YlqD; pfam11068 545693011240 KH domain; Region: KH_4; pfam13083 545693011241 G-X-X-G motif; other site 545693011242 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 545693011243 signal recognition particle protein; Provisional; Region: PRK10867 545693011244 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 545693011245 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 545693011246 P loop; other site 545693011247 GTP binding site [chemical binding]; other site 545693011248 Signal peptide binding domain; Region: SRP_SPB; pfam02978 545693011249 putative DNA-binding protein; Validated; Region: PRK00118 545693011250 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693011251 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 545693011252 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 545693011253 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 545693011254 P loop; other site 545693011255 GTP binding site [chemical binding]; other site 545693011256 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 545693011257 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 545693011258 Walker A/P-loop; other site 545693011259 ATP binding site [chemical binding]; other site 545693011260 Q-loop/lid; other site 545693011261 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 545693011262 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 545693011263 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 545693011264 ABC transporter signature motif; other site 545693011265 Walker B; other site 545693011266 D-loop; other site 545693011267 H-loop/switch region; other site 545693011268 ribonuclease III; Reviewed; Region: rnc; PRK00102 545693011269 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 545693011270 dimerization interface [polypeptide binding]; other site 545693011271 active site 545693011272 metal binding site [ion binding]; metal-binding site 545693011273 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 545693011274 dsRNA binding site [nucleotide binding]; other site 545693011275 acyl carrier protein; Provisional; Region: acpP; PRK00982 545693011276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693011277 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693011278 NAD(P) binding site [chemical binding]; other site 545693011279 homotetramer interface [polypeptide binding]; other site 545693011280 homodimer interface [polypeptide binding]; other site 545693011281 active site 545693011282 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 545693011283 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 545693011284 putative phosphate acyltransferase; Provisional; Region: PRK05331 545693011285 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 545693011286 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 545693011287 active site 2 [active] 545693011288 active site 1 [active] 545693011289 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 545693011290 Y-family of DNA polymerases; Region: PolY; cl12025 545693011291 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 545693011292 generic binding surface II; other site 545693011293 ssDNA binding site; other site 545693011294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693011295 ATP binding site [chemical binding]; other site 545693011296 putative Mg++ binding site [ion binding]; other site 545693011297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693011298 nucleotide binding region [chemical binding]; other site 545693011299 ATP-binding site [chemical binding]; other site 545693011300 L-serine dehydratase, iron-sulfur-dependent, alpha subunit, frameshift 545693011301 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 545693011302 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 545693011303 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 545693011304 putative L-serine binding site [chemical binding]; other site 545693011305 putative regulatory protein, frameshift 545693011306 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 545693011307 DAK2 domain; Region: Dak2; pfam02734 545693011308 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 545693011309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 545693011310 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 545693011311 Thiamine pyrophosphokinase; Region: TPK; cd07995 545693011312 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 545693011313 active site 545693011314 dimerization interface [polypeptide binding]; other site 545693011315 thiamine binding site [chemical binding]; other site 545693011316 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 545693011317 substrate binding site [chemical binding]; other site 545693011318 hexamer interface [polypeptide binding]; other site 545693011319 metal binding site [ion binding]; metal-binding site 545693011320 GTPase RsgA; Reviewed; Region: PRK00098 545693011321 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 545693011322 RNA binding site [nucleotide binding]; other site 545693011323 homodimer interface [polypeptide binding]; other site 545693011324 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 545693011325 GTPase/Zn-binding domain interface [polypeptide binding]; other site 545693011326 GTP/Mg2+ binding site [chemical binding]; other site 545693011327 G4 box; other site 545693011328 G5 box; other site 545693011329 G1 box; other site 545693011330 Switch I region; other site 545693011331 G2 box; other site 545693011332 G3 box; other site 545693011333 Switch II region; other site 545693011334 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 545693011335 Catalytic domain of Protein Kinases; Region: PKc; cd00180 545693011336 active site 545693011337 ATP binding site [chemical binding]; other site 545693011338 substrate binding site [chemical binding]; other site 545693011339 activation loop (A-loop); other site 545693011340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 545693011341 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 545693011342 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 545693011343 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 545693011344 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 545693011345 active site 545693011346 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 545693011347 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 545693011348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693011349 FeS/SAM binding site; other site 545693011350 16S rRNA methyltransferase B; Provisional; Region: PRK14902 545693011351 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 545693011352 putative RNA binding site [nucleotide binding]; other site 545693011353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011354 S-adenosylmethionine binding site [chemical binding]; other site 545693011355 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 545693011356 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 545693011357 putative active site [active] 545693011358 substrate binding site [chemical binding]; other site 545693011359 putative cosubstrate binding site; other site 545693011360 catalytic site [active] 545693011361 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 545693011362 substrate binding site [chemical binding]; other site 545693011363 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 545693011364 active site 545693011365 catalytic residues [active] 545693011366 metal binding site [ion binding]; metal-binding site 545693011367 primosome assembly protein PriA; Validated; Region: PRK05580 545693011368 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 545693011369 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 545693011370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693011371 ATP-binding site [chemical binding]; other site 545693011372 ATP binding site [chemical binding]; other site 545693011373 putative Mg++ binding site [ion binding]; other site 545693011374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693011375 nucleotide binding region [chemical binding]; other site 545693011376 ATP-binding site [chemical binding]; other site 545693011377 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 545693011378 Flavoprotein; Region: Flavoprotein; cl19190 545693011379 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 545693011380 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 545693011381 Guanylate kinase; Region: Guanylate_kin; pfam00625 545693011382 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 545693011383 catalytic site [active] 545693011384 G-X2-G-X-G-K; other site 545693011385 hypothetical protein; Provisional; Region: PRK11820 545693011386 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 545693011387 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 545693011388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 545693011389 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 545693011390 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693011391 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 545693011392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693011393 motif II; other site 545693011394 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 545693011395 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 545693011396 Domain of unknown function (DUF814); Region: DUF814; pfam05670 545693011397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693011398 active site 545693011399 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 545693011400 active site 545693011401 dimer interface [polypeptide binding]; other site 545693011402 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 545693011403 heterodimer interface [polypeptide binding]; other site 545693011404 active site 545693011405 FMN binding site [chemical binding]; other site 545693011406 homodimer interface [polypeptide binding]; other site 545693011407 substrate binding site [chemical binding]; other site 545693011408 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 545693011409 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 545693011410 FAD binding pocket [chemical binding]; other site 545693011411 FAD binding motif [chemical binding]; other site 545693011412 phosphate binding motif [ion binding]; other site 545693011413 beta-alpha-beta structure motif; other site 545693011414 NAD binding pocket [chemical binding]; other site 545693011415 Iron coordination center [ion binding]; other site 545693011416 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 545693011417 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693011418 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 545693011419 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 545693011420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693011421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 545693011422 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 545693011423 IMP binding site; other site 545693011424 dimer interface [polypeptide binding]; other site 545693011425 interdomain contacts; other site 545693011426 partial ornithine binding site; other site 545693011427 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 545693011428 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 545693011429 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 545693011430 catalytic site [active] 545693011431 subunit interface [polypeptide binding]; other site 545693011432 dihydroorotase; Validated; Region: pyrC; PRK09357 545693011433 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693011434 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 545693011435 active site 545693011436 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 545693011437 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 545693011438 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 545693011439 Sulfate transporter family; Region: Sulfate_transp; cl19250 545693011440 uracil-xanthine permease; Region: ncs2; TIGR00801 545693011441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693011442 active site 545693011443 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 545693011444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693011445 RNA binding surface [nucleotide binding]; other site 545693011446 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 545693011447 active site 545693011448 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 545693011449 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 545693011450 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 545693011451 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 545693011452 active site 545693011453 HIGH motif; other site 545693011454 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 545693011455 KMSKS motif; other site 545693011456 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 545693011457 tRNA binding surface [nucleotide binding]; other site 545693011458 anticodon binding site; other site 545693011459 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 545693011460 DivIVA protein; Region: DivIVA; pfam05103 545693011461 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 545693011462 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 545693011463 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693011464 RNA binding surface [nucleotide binding]; other site 545693011465 YGGT family; Region: YGGT; pfam02325 545693011466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 545693011467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 545693011468 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693011469 catalytic residue [active] 545693011470 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 545693011471 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 545693011472 sporulation sigma factor SigG; Reviewed; Region: PRK08215 545693011473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011474 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693011475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011476 DNA binding residues [nucleotide binding] 545693011477 sporulation sigma factor SigE; Reviewed; Region: PRK08301 545693011478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011479 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011480 DNA binding residues [nucleotide binding] 545693011481 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 545693011482 cell division protein FtsZ; Validated; Region: PRK09330 545693011483 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 545693011484 nucleotide binding site [chemical binding]; other site 545693011485 SulA interaction site; other site 545693011486 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 545693011487 Cell division protein FtsA; Region: FtsA; smart00842 545693011488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 545693011489 nucleotide binding site [chemical binding]; other site 545693011490 Cell division protein FtsA; Region: FtsA; pfam14450 545693011491 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 545693011492 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 545693011493 Cell division protein FtsQ; Region: FtsQ; pfam03799 545693011494 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 545693011495 FAD binding domain; Region: FAD_binding_4; pfam01565 545693011496 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 545693011497 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 545693011498 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 545693011499 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 545693011500 NAD binding site [chemical binding]; other site 545693011501 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693011502 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693011503 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 545693011504 Mg++ binding site [ion binding]; other site 545693011505 putative catalytic motif [active] 545693011506 putative substrate binding site [chemical binding]; other site 545693011507 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 545693011508 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693011509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693011510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693011511 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 545693011512 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 545693011513 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693011514 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 545693011515 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693011516 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 545693011517 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693011518 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 545693011519 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 545693011520 Cell division protein FtsL; Region: FtsL; cl11433 545693011521 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 545693011522 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 545693011523 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 545693011524 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 545693011525 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 545693011526 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 545693011527 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 545693011528 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 545693011529 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 545693011530 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 545693011531 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693011532 carboxyltransferase (CT) interaction site; other site 545693011533 biotinylation site [posttranslational modification]; other site 545693011534 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 545693011535 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693011536 ATP-grasp domain; Region: ATP-grasp_4; cl17255 545693011537 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 545693011538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693011539 Coenzyme A binding pocket [chemical binding]; other site 545693011540 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 545693011541 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 545693011542 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693011543 substrate binding site [chemical binding]; other site 545693011544 oxyanion hole (OAH) forming residues; other site 545693011545 trimer interface [polypeptide binding]; other site 545693011546 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 545693011547 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 545693011548 hypothetical protein; Provisional; Region: PRK13670 545693011549 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 545693011550 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 545693011551 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 545693011552 protein binding site [polypeptide binding]; other site 545693011553 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 545693011554 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 545693011555 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 545693011556 active site 545693011557 nucleophile elbow; other site 545693011558 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 545693011559 Nucleoside recognition; Region: Gate; pfam07670 545693011560 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 545693011561 active site 545693011562 (T/H)XGH motif; other site 545693011563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011564 S-adenosylmethionine binding site [chemical binding]; other site 545693011565 hypothetical protein; Provisional; Region: PRK02886 545693011566 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 545693011567 YlbE-like protein; Region: YlbE; pfam14003 545693011568 Putative coat protein; Region: YlbD_coat; pfam14071 545693011569 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 545693011570 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 545693011571 interchain domain interface [polypeptide binding]; other site 545693011572 intrachain domain interface; other site 545693011573 Qi binding site; other site 545693011574 Qo binding site; other site 545693011575 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 545693011576 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 545693011577 cytochrome b6; Provisional; Region: PRK03735 545693011578 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 545693011579 interchain domain interface [polypeptide binding]; other site 545693011580 intrachain domain interface; other site 545693011581 heme bH binding site [chemical binding]; other site 545693011582 Qi binding site; other site 545693011583 heme bL binding site [chemical binding]; other site 545693011584 Qo binding site; other site 545693011585 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 545693011586 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 545693011587 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 545693011588 iron-sulfur cluster [ion binding]; other site 545693011589 [2Fe-2S] cluster binding site [ion binding]; other site 545693011590 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 545693011591 hypothetical protein; Provisional; Region: PRK03636 545693011592 UPF0302 domain; Region: UPF0302; pfam08864 545693011593 IDEAL domain; Region: IDEAL; pfam08858 545693011594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011595 binding surface 545693011596 TPR motif; other site 545693011597 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 545693011598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011599 binding surface 545693011600 TPR motif; other site 545693011601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011602 binding surface 545693011603 TPR motif; other site 545693011604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011605 binding surface 545693011606 TPR motif; other site 545693011607 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 545693011608 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 545693011609 hinge; other site 545693011610 active site 545693011611 prephenate dehydrogenase; Validated; Region: PRK06545 545693011612 prephenate dehydrogenase; Validated; Region: PRK08507 545693011613 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 545693011614 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 545693011615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693011616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011617 homodimer interface [polypeptide binding]; other site 545693011618 catalytic residue [active] 545693011619 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 545693011620 substrate binding site [chemical binding]; other site 545693011621 active site 545693011622 catalytic residues [active] 545693011623 heterodimer interface [polypeptide binding]; other site 545693011624 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 545693011625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011626 catalytic residue [active] 545693011627 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 545693011628 active site 545693011629 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 545693011630 active site 545693011631 ribulose/triose binding site [chemical binding]; other site 545693011632 phosphate binding site [ion binding]; other site 545693011633 substrate (anthranilate) binding pocket [chemical binding]; other site 545693011634 product (indole) binding pocket [chemical binding]; other site 545693011635 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 545693011636 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 545693011637 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 545693011638 anthranilate synthase component I; Provisional; Region: PRK13569 545693011639 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 545693011640 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 545693011641 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 545693011642 active site 545693011643 dimer interface [polypeptide binding]; other site 545693011644 metal binding site [ion binding]; metal-binding site 545693011645 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 545693011646 Tetramer interface [polypeptide binding]; other site 545693011647 active site 545693011648 FMN-binding site [chemical binding]; other site 545693011649 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 545693011650 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 545693011651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011652 S-adenosylmethionine binding site [chemical binding]; other site 545693011653 Nucleoside diphosphate kinase; Region: NDK; pfam00334 545693011654 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 545693011655 active site 545693011656 multimer interface [polypeptide binding]; other site 545693011657 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 545693011658 substrate binding pocket [chemical binding]; other site 545693011659 chain length determination region; other site 545693011660 substrate-Mg2+ binding site; other site 545693011661 catalytic residues [active] 545693011662 aspartate-rich region 1; other site 545693011663 active site lid residues [active] 545693011664 aspartate-rich region 2; other site 545693011665 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 545693011666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011667 S-adenosylmethionine binding site [chemical binding]; other site 545693011668 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 545693011669 transcription attenuation protein MtrB; Provisional; Region: PRK13251 545693011670 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 545693011671 homodecamer interface [polypeptide binding]; other site 545693011672 active site 545693011673 putative catalytic site residues [active] 545693011674 zinc binding site [ion binding]; other site 545693011675 GTP-CH-I/GFRP interaction surface; other site 545693011676 histone-like DNA-binding protein HU; Region: HU; cd13831 545693011677 dimer interface [polypeptide binding]; other site 545693011678 DNA binding site [nucleotide binding] 545693011679 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 545693011680 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 545693011681 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 545693011682 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 545693011683 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 545693011684 GTP-binding protein Der; Reviewed; Region: PRK00093 545693011685 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 545693011686 G1 box; other site 545693011687 GTP/Mg2+ binding site [chemical binding]; other site 545693011688 Switch I region; other site 545693011689 G2 box; other site 545693011690 Switch II region; other site 545693011691 G3 box; other site 545693011692 G4 box; other site 545693011693 G5 box; other site 545693011694 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 545693011695 G1 box; other site 545693011696 GTP/Mg2+ binding site [chemical binding]; other site 545693011697 Switch I region; other site 545693011698 G2 box; other site 545693011699 G3 box; other site 545693011700 Switch II region; other site 545693011701 G4 box; other site 545693011702 G5 box; other site 545693011703 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 545693011704 YpzI-like protein; Region: YpzI; pfam14140 545693011705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693011706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693011707 putative substrate translocation pore; other site 545693011708 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 545693011709 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 545693011710 homotetramer interface [polypeptide binding]; other site 545693011711 FMN binding site [chemical binding]; other site 545693011712 homodimer contacts [polypeptide binding]; other site 545693011713 putative active site [active] 545693011714 putative substrate binding site [chemical binding]; other site 545693011715 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 545693011716 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 545693011717 RNA binding site [nucleotide binding]; other site 545693011718 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 545693011719 RNA binding site [nucleotide binding]; other site 545693011720 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 545693011721 RNA binding site [nucleotide binding]; other site 545693011722 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693011723 RNA binding site [nucleotide binding]; other site 545693011724 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 545693011725 putative acyl-acceptor binding pocket; other site 545693011726 cytidylate kinase; Provisional; Region: cmk; PRK00023 545693011727 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 545693011728 CMP-binding site; other site 545693011729 The sites determining sugar specificity; other site 545693011730 Flagellar protein YcgR; Region: YcgR_2; pfam12945 545693011731 PilZ domain; Region: PilZ; pfam07238 545693011732 germination protein YpeB; Region: spore_YpeB; TIGR02889 545693011733 YpeB sporulation; Region: YPEB; pfam14620 545693011734 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 545693011735 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693011736 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693011737 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 545693011738 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 545693011739 active site 545693011740 homotetramer interface [polypeptide binding]; other site 545693011741 homodimer interface [polypeptide binding]; other site 545693011742 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 545693011743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 545693011744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693011745 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 545693011746 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 545693011747 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 545693011748 NAD(P) binding site [chemical binding]; other site 545693011749 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 545693011750 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 545693011751 DNA binding residues [nucleotide binding] 545693011752 B12 binding domain; Region: B12-binding_2; pfam02607 545693011753 B12 binding domain; Region: B12-binding; pfam02310 545693011754 B12 binding site [chemical binding]; other site 545693011755 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 545693011756 putative active site [active] 545693011757 putative metal binding site [ion binding]; other site 545693011758 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 545693011759 CAAX protease self-immunity; Region: Abi; pfam02517 545693011760 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693011761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693011762 ATP binding site [chemical binding]; other site 545693011763 putative Mg++ binding site [ion binding]; other site 545693011764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693011765 nucleotide binding region [chemical binding]; other site 545693011766 ATP-binding site [chemical binding]; other site 545693011767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 545693011768 Helix-turn-helix domain; Region: HTH_40; pfam14493 545693011769 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 545693011770 Predicted membrane protein [Function unknown]; Region: COG3601 545693011771 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 545693011772 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 545693011773 ligand binding site [chemical binding]; other site 545693011774 NAD binding site [chemical binding]; other site 545693011775 dimerization interface [polypeptide binding]; other site 545693011776 catalytic site [active] 545693011777 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 545693011778 putative L-serine binding site [chemical binding]; other site 545693011779 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 545693011780 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693011781 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693011782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 545693011783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693011784 dimerization interface [polypeptide binding]; other site 545693011785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693011786 dimer interface [polypeptide binding]; other site 545693011787 phosphorylation site [posttranslational modification] 545693011788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693011789 ATP binding site [chemical binding]; other site 545693011790 Mg2+ binding site [ion binding]; other site 545693011791 G-X-G motif; other site 545693011792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693011793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693011794 active site 545693011795 phosphorylation site [posttranslational modification] 545693011796 intermolecular recognition site; other site 545693011797 dimerization interface [polypeptide binding]; other site 545693011798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693011799 DNA binding site [nucleotide binding] 545693011800 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 545693011801 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 545693011802 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 545693011803 catalytic residues [active] 545693011804 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 545693011805 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693011806 RNA binding surface [nucleotide binding]; other site 545693011807 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 545693011808 active site 545693011809 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 545693011810 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 545693011811 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 545693011812 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 545693011813 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 545693011814 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 545693011815 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 545693011816 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 545693011817 Domain of unknown function (DUF309); Region: DUF309; pfam03745 545693011818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693011819 Coenzyme A binding pocket [chemical binding]; other site 545693011820 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 545693011821 active site 545693011822 Predicted secreted protein [Function unknown]; Region: COG4086 545693011823 diaminopimelate decarboxylase; Region: lysA; TIGR01048 545693011824 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 545693011825 active site 545693011826 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693011827 substrate binding site [chemical binding]; other site 545693011828 catalytic residues [active] 545693011829 dimer interface [polypeptide binding]; other site 545693011830 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693011831 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 545693011832 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 545693011833 stage V sporulation protein AD; Validated; Region: PRK08304 545693011834 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 545693011835 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 545693011836 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 545693011837 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 545693011838 sporulation sigma factor SigF; Validated; Region: PRK05572 545693011839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011840 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693011841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011842 DNA binding residues [nucleotide binding] 545693011843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693011844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693011845 ATP binding site [chemical binding]; other site 545693011846 Mg2+ binding site [ion binding]; other site 545693011847 G-X-G motif; other site 545693011848 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 545693011849 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 545693011850 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 545693011851 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 545693011852 purine nucleoside phosphorylase; Provisional; Region: PRK08202 545693011853 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 545693011854 phosphopentomutase; Provisional; Region: PRK05362 545693011855 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 545693011856 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 545693011857 active site 545693011858 Int/Topo IB signature motif; other site 545693011859 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 545693011860 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 545693011861 metal binding site 2 [ion binding]; metal-binding site 545693011862 putative DNA binding helix; other site 545693011863 metal binding site 1 [ion binding]; metal-binding site 545693011864 dimer interface [polypeptide binding]; other site 545693011865 structural Zn2+ binding site [ion binding]; other site 545693011866 stage II sporulation protein M; Region: spo_II_M; TIGR02831 545693011867 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 545693011868 dimer interface [polypeptide binding]; other site 545693011869 ADP-ribose binding site [chemical binding]; other site 545693011870 active site 545693011871 nudix motif; other site 545693011872 metal binding site [ion binding]; metal-binding site 545693011873 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 545693011874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693011875 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 545693011876 active site 545693011877 catalytic tetrad [active] 545693011878 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 545693011879 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 545693011880 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 545693011881 putative acyltransferase; Provisional; Region: PRK05790 545693011882 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693011883 dimer interface [polypeptide binding]; other site 545693011884 active site 545693011885 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 545693011886 active site 545693011887 catalytic residues [active] 545693011888 metal binding site [ion binding]; metal-binding site 545693011889 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693011890 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693011891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 545693011892 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 545693011893 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693011894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011895 NAD(P) binding site [chemical binding]; other site 545693011896 active site 545693011897 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 545693011898 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 545693011899 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 545693011900 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 545693011901 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 545693011902 active site 545693011903 FMN binding site [chemical binding]; other site 545693011904 substrate binding site [chemical binding]; other site 545693011905 homotetramer interface [polypeptide binding]; other site 545693011906 catalytic residue [active] 545693011907 ribonuclease Z; Region: RNase_Z; TIGR02651 545693011908 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 545693011909 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693011910 inhibitor-cofactor binding pocket; inhibition site 545693011911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011912 catalytic residue [active] 545693011913 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 545693011914 tetrameric interface [polypeptide binding]; other site 545693011915 NAD binding site [chemical binding]; other site 545693011916 catalytic residues [active] 545693011917 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 545693011918 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693011919 Nrap protein; Region: Nrap; pfam03813 545693011920 phenylhydantoinase; Validated; Region: PRK08323 545693011921 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 545693011922 tetramer interface [polypeptide binding]; other site 545693011923 active site 545693011924 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 545693011925 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 545693011926 homodimer interface [polypeptide binding]; other site 545693011927 active site 545693011928 FMN binding site [chemical binding]; other site 545693011929 substrate binding site [chemical binding]; other site 545693011930 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 545693011931 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 545693011932 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 545693011933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693011934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693011935 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 545693011936 peptidase T-like protein; Region: PepT-like; TIGR01883 545693011937 metal binding site [ion binding]; metal-binding site 545693011938 putative dimer interface [polypeptide binding]; other site 545693011939 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 545693011940 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 545693011941 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 545693011942 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 545693011943 dimer interface [polypeptide binding]; other site 545693011944 substrate binding site [chemical binding]; other site 545693011945 metal binding site [ion binding]; metal-binding site 545693011946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 545693011947 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 545693011948 Predicted membrane protein [Function unknown]; Region: COG4129 545693011949 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 545693011950 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 545693011951 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693011952 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 545693011953 Walker A/P-loop; other site 545693011954 ATP binding site [chemical binding]; other site 545693011955 Q-loop/lid; other site 545693011956 ABC transporter signature motif; other site 545693011957 Walker B; other site 545693011958 D-loop; other site 545693011959 H-loop/switch region; other site 545693011960 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 545693011961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693011962 dimer interface [polypeptide binding]; other site 545693011963 conserved gate region; other site 545693011964 putative PBP binding loops; other site 545693011965 ABC-ATPase subunit interface; other site 545693011966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693011967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693011968 substrate binding pocket [chemical binding]; other site 545693011969 membrane-bound complex binding site; other site 545693011970 hinge residues; other site 545693011971 Disulphide isomerase; Region: Disulph_isomer; pfam06491 545693011972 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 545693011973 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 545693011974 Walker A; other site 545693011975 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 545693011976 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 545693011977 active site 545693011978 substrate binding site [chemical binding]; other site 545693011979 coenzyme B12 binding site [chemical binding]; other site 545693011980 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 545693011981 B12 binding site [chemical binding]; other site 545693011982 cobalt ligand [ion binding]; other site 545693011983 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 545693011984 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 545693011985 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 545693011986 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 545693011987 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693011988 E3 interaction surface; other site 545693011989 lipoyl attachment site [posttranslational modification]; other site 545693011990 e3 binding domain; Region: E3_binding; pfam02817 545693011991 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 545693011992 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 545693011993 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 545693011994 alpha subunit interface [polypeptide binding]; other site 545693011995 TPP binding site [chemical binding]; other site 545693011996 heterodimer interface [polypeptide binding]; other site 545693011997 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693011998 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 545693011999 tetramer interface [polypeptide binding]; other site 545693012000 TPP-binding site [chemical binding]; other site 545693012001 heterodimer interface [polypeptide binding]; other site 545693012002 phosphorylation loop region [posttranslational modification] 545693012003 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 545693012004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693012005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693012006 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 545693012007 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 545693012008 nucleotide binding site [chemical binding]; other site 545693012009 Acetokinase family; Region: Acetate_kinase; cl17229 545693012010 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 545693012011 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 545693012012 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 545693012013 NAD binding site [chemical binding]; other site 545693012014 Phe binding site; other site 545693012015 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 545693012016 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693012017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693012018 putative active site [active] 545693012019 heme pocket [chemical binding]; other site 545693012020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693012021 putative active site [active] 545693012022 heme pocket [chemical binding]; other site 545693012023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012024 Walker A motif; other site 545693012025 ATP binding site [chemical binding]; other site 545693012026 Walker B motif; other site 545693012027 arginine finger; other site 545693012028 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 545693012029 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 545693012030 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 545693012031 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 545693012032 active site 545693012033 catalytic site [active] 545693012034 metal binding site [ion binding]; metal-binding site 545693012035 dimer interface [polypeptide binding]; other site 545693012036 YycC-like protein; Region: YycC; pfam14174 545693012037 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 545693012038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693012039 putative substrate translocation pore; other site 545693012040 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 545693012041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693012042 active site 545693012043 phosphorylation site [posttranslational modification] 545693012044 intermolecular recognition site; other site 545693012045 dimerization interface [polypeptide binding]; other site 545693012046 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 545693012047 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 545693012048 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 545693012049 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 545693012050 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 545693012051 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 545693012052 Walker A/P-loop; other site 545693012053 ATP binding site [chemical binding]; other site 545693012054 Q-loop/lid; other site 545693012055 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 545693012056 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 545693012057 ABC transporter signature motif; other site 545693012058 Walker B; other site 545693012059 D-loop; other site 545693012060 H-loop/switch region; other site 545693012061 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 545693012062 arginine repressor; Provisional; Region: PRK04280 545693012063 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 545693012064 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 545693012065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693012066 RNA binding surface [nucleotide binding]; other site 545693012067 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 545693012068 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 545693012069 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 545693012070 TPP-binding site; other site 545693012071 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693012072 PYR/PP interface [polypeptide binding]; other site 545693012073 dimer interface [polypeptide binding]; other site 545693012074 TPP binding site [chemical binding]; other site 545693012075 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693012076 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 545693012077 substrate binding pocket [chemical binding]; other site 545693012078 chain length determination region; other site 545693012079 active site lid residues [active] 545693012080 substrate-Mg2+ binding site; other site 545693012081 catalytic residues [active] 545693012082 aspartate-rich region 1; other site 545693012083 aspartate-rich region 2; other site 545693012084 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 545693012085 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 545693012086 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 545693012087 generic binding surface II; other site 545693012088 generic binding surface I; other site 545693012089 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693012090 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 545693012091 putative RNA binding site [nucleotide binding]; other site 545693012092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 545693012093 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 545693012094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693012095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 545693012096 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 545693012097 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 545693012098 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693012099 carboxyltransferase (CT) interaction site; other site 545693012100 biotinylation site [posttranslational modification]; other site 545693012101 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 545693012102 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 545693012103 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 545693012104 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 545693012105 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 545693012106 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 545693012107 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 545693012108 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 545693012109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012110 Walker A motif; other site 545693012111 ATP binding site [chemical binding]; other site 545693012112 Walker B motif; other site 545693012113 arginine finger; other site 545693012114 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 545693012115 elongation factor P; Validated; Region: PRK00529 545693012116 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 545693012117 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 545693012118 RNA binding site [nucleotide binding]; other site 545693012119 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 545693012120 RNA binding site [nucleotide binding]; other site 545693012121 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 545693012122 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 545693012123 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 545693012124 active site 545693012125 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 545693012126 trimer interface [polypeptide binding]; other site 545693012127 active site 545693012128 dimer interface [polypeptide binding]; other site 545693012129 Conserved membrane protein YqhR; Region: YqhR; pfam11085 545693012130 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 545693012131 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 545693012132 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 545693012133 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 545693012134 active site 545693012135 nucleophile elbow; other site 545693012136 manganese transport transcriptional regulator; Provisional; Region: PRK03902 545693012137 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 545693012138 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 545693012139 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, degenerate 545693012140 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 545693012141 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693012142 active site residue [active] 545693012143 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 545693012144 tetramer interface [polypeptide binding]; other site 545693012145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012146 catalytic residue [active] 545693012147 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 545693012148 tetramer interface [polypeptide binding]; other site 545693012149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012150 catalytic residue [active] 545693012151 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 545693012152 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 545693012153 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 545693012154 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693012155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693012156 ATP binding site [chemical binding]; other site 545693012157 putative Mg++ binding site [ion binding]; other site 545693012158 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 545693012159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693012160 nucleotide binding region [chemical binding]; other site 545693012161 ATP-binding site [chemical binding]; other site 545693012162 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 545693012163 YqzE-like protein; Region: YqzE; pfam14038 545693012164 ComG operon protein 7; Region: ComGG; pfam14173 545693012165 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 545693012166 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 545693012167 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 545693012168 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 545693012169 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 545693012170 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 545693012171 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 545693012172 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 545693012173 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 545693012174 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 545693012175 Walker A motif; other site 545693012176 ATP binding site [chemical binding]; other site 545693012177 Walker B motif; other site 545693012178 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 545693012179 putative catalytic residues [active] 545693012180 thiol/disulfide switch; other site 545693012181 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 545693012182 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 545693012183 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 545693012184 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 545693012185 putative active site [active] 545693012186 Zn binding site [ion binding]; other site 545693012187 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 545693012188 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 545693012189 nucleotide binding site [chemical binding]; other site 545693012190 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 545693012191 Rhomboid family; Region: Rhomboid; pfam01694 545693012192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693012193 TPR motif; other site 545693012194 binding surface 545693012195 TPR repeat; Region: TPR_11; pfam13414 545693012196 Integral membrane protein DUF92; Region: DUF92; pfam01940 545693012197 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 545693012198 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 545693012199 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 545693012200 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 545693012201 active site 545693012202 Substrate binding site; other site 545693012203 Mg++ binding site; other site 545693012204 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 545693012205 putative trimer interface [polypeptide binding]; other site 545693012206 putative CoA binding site [chemical binding]; other site 545693012207 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 545693012208 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 545693012209 active site 545693012210 substrate binding site [chemical binding]; other site 545693012211 metal binding site [ion binding]; metal-binding site 545693012212 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 545693012213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693012214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693012215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 545693012216 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 545693012217 PhoU domain; Region: PhoU; pfam01895 545693012218 PhoU domain; Region: PhoU; pfam01895 545693012219 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 545693012220 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 545693012221 Walker A/P-loop; other site 545693012222 ATP binding site [chemical binding]; other site 545693012223 Q-loop/lid; other site 545693012224 ABC transporter signature motif; other site 545693012225 Walker B; other site 545693012226 D-loop; other site 545693012227 H-loop/switch region; other site 545693012228 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693012229 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 545693012230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693012231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693012232 putative substrate translocation pore; other site 545693012233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693012234 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 545693012235 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 545693012236 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 545693012237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 545693012238 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 545693012239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693012240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693012241 putative substrate translocation pore; other site 545693012242 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 545693012243 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 545693012244 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 545693012245 Uncharacterized conserved protein [Function unknown]; Region: COG5663 545693012246 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 545693012247 metal binding site 2 [ion binding]; metal-binding site 545693012248 putative DNA binding helix; other site 545693012249 metal binding site 1 [ion binding]; metal-binding site 545693012250 dimer interface [polypeptide binding]; other site 545693012251 structural Zn2+ binding site [ion binding]; other site 545693012252 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693012253 ABC-ATPase subunit interface; other site 545693012254 dimer interface [polypeptide binding]; other site 545693012255 putative PBP binding regions; other site 545693012256 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 545693012257 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 545693012258 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 545693012259 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 545693012260 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 545693012261 AP (apurinic/apyrimidinic) site pocket; other site 545693012262 DNA interaction; other site 545693012263 Metal-binding active site; metal-binding site 545693012264 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693012265 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693012266 ATP binding site [chemical binding]; other site 545693012267 Mg++ binding site [ion binding]; other site 545693012268 motif III; other site 545693012269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693012270 nucleotide binding region [chemical binding]; other site 545693012271 ATP-binding site [chemical binding]; other site 545693012272 YqfQ-like protein; Region: YqfQ; pfam14181 545693012273 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 545693012274 Fe-S cluster binding site [ion binding]; other site 545693012275 substrate binding site [chemical binding]; other site 545693012276 catalytic site [active] 545693012277 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 545693012278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 545693012279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 545693012280 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 545693012281 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 545693012282 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693012283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693012284 active site 545693012285 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 545693012286 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 545693012287 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 545693012288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693012289 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693012290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693012291 DNA binding residues [nucleotide binding] 545693012292 DNA primase; Validated; Region: dnaG; PRK05667 545693012293 CHC2 zinc finger; Region: zf-CHC2; pfam01807 545693012294 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 545693012295 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 545693012296 active site 545693012297 metal binding site [ion binding]; metal-binding site 545693012298 interdomain interaction site; other site 545693012299 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 545693012300 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 545693012301 PEP synthetase regulatory protein; Provisional; Region: PRK05339 545693012302 HTH domain; Region: HTH_11; pfam08279 545693012303 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 545693012304 FOG: CBS domain [General function prediction only]; Region: COG0517 545693012305 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 545693012306 Recombination protein O N terminal; Region: RecO_N; pfam11967 545693012307 Recombination protein O C terminal; Region: RecO_C; pfam02565 545693012308 GTPase Era; Reviewed; Region: era; PRK00089 545693012309 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 545693012310 G1 box; other site 545693012311 GTP/Mg2+ binding site [chemical binding]; other site 545693012312 Switch I region; other site 545693012313 G2 box; other site 545693012314 Switch II region; other site 545693012315 G3 box; other site 545693012316 G4 box; other site 545693012317 G5 box; other site 545693012318 KH domain; Region: KH_2; pfam07650 545693012319 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 545693012320 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 545693012321 active site 545693012322 catalytic motif [active] 545693012323 Zn binding site [ion binding]; other site 545693012324 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 545693012325 trimer interface [polypeptide binding]; other site 545693012326 putative active site [active] 545693012327 Zn binding site [ion binding]; other site 545693012328 metal-binding heat shock protein; Provisional; Region: PRK00016 545693012329 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 545693012330 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 545693012331 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 545693012332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693012333 Zn2+ binding site [ion binding]; other site 545693012334 Mg2+ binding site [ion binding]; other site 545693012335 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 545693012336 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 545693012337 PhoH-like protein; Region: PhoH; pfam02562 545693012338 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 545693012339 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 545693012340 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 545693012341 hypothetical protein; Provisional; Region: PRK13665 545693012342 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 545693012343 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 545693012344 dimer interface [polypeptide binding]; other site 545693012345 active site residues [active] 545693012346 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 545693012347 Yqey-like protein; Region: YqeY; pfam09424 545693012348 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 545693012349 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 545693012350 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 545693012351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693012352 FeS/SAM binding site; other site 545693012353 TRAM domain; Region: TRAM; cl01282 545693012354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 545693012355 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 545693012356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693012357 S-adenosylmethionine binding site [chemical binding]; other site 545693012358 chaperone protein DnaJ; Provisional; Region: PRK14280 545693012359 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 545693012360 HSP70 interaction site [polypeptide binding]; other site 545693012361 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 545693012362 substrate binding site [polypeptide binding]; other site 545693012363 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 545693012364 Zn binding sites [ion binding]; other site 545693012365 dimer interface [polypeptide binding]; other site 545693012366 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 545693012367 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 545693012368 nucleotide binding site [chemical binding]; other site 545693012369 NEF interaction site [polypeptide binding]; other site 545693012370 SBD interface [polypeptide binding]; other site 545693012371 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 545693012372 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 545693012373 dimer interface [polypeptide binding]; other site 545693012374 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 545693012375 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 545693012376 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 545693012377 HrcA protein C terminal domain; Region: HrcA; pfam01628 545693012378 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 545693012379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693012380 FeS/SAM binding site; other site 545693012381 HemN C-terminal domain; Region: HemN_C; pfam06969 545693012382 GTP-binding protein LepA; Provisional; Region: PRK05433 545693012383 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 545693012384 G1 box; other site 545693012385 putative GEF interaction site [polypeptide binding]; other site 545693012386 GTP/Mg2+ binding site [chemical binding]; other site 545693012387 Switch I region; other site 545693012388 G2 box; other site 545693012389 G3 box; other site 545693012390 Switch II region; other site 545693012391 G4 box; other site 545693012392 G5 box; other site 545693012393 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 545693012394 Elongation Factor G, domain II; Region: EFG_II; pfam14492 545693012395 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 545693012396 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 545693012397 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 545693012398 germination protease; Provisional; Region: PRK02858 545693012399 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 545693012400 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 545693012401 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 545693012402 YqzM-like protein; Region: YqzM; pfam14141 545693012403 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 545693012404 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 545693012405 Competence protein; Region: Competence; pfam03772 545693012406 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693012407 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 545693012408 catalytic motif [active] 545693012409 Zn binding site [ion binding]; other site 545693012410 SLBB domain; Region: SLBB; pfam10531 545693012411 comEA protein; Region: comE; TIGR01259 545693012412 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 545693012413 late competence protein ComER; Validated; Region: PRK07680 545693012414 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 545693012415 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 545693012416 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 545693012417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693012418 S-adenosylmethionine binding site [chemical binding]; other site 545693012419 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 545693012420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693012421 Zn2+ binding site [ion binding]; other site 545693012422 Mg2+ binding site [ion binding]; other site 545693012423 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 545693012424 active site 545693012425 (T/H)XGH motif; other site 545693012426 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 545693012427 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 545693012428 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 545693012429 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 545693012430 shikimate binding site; other site 545693012431 NAD(P) binding site [chemical binding]; other site 545693012432 GTPase YqeH; Provisional; Region: PRK13796 545693012433 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 545693012434 GTP/Mg2+ binding site [chemical binding]; other site 545693012435 G4 box; other site 545693012436 G5 box; other site 545693012437 G1 box; other site 545693012438 Switch I region; other site 545693012439 G2 box; other site 545693012440 G3 box; other site 545693012441 Switch II region; other site 545693012442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693012443 active site 545693012444 motif I; other site 545693012445 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 545693012446 motif II; other site 545693012447 Sporulation inhibitor A; Region: Sda; pfam08970 545693012448 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 545693012449 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693012450 sporulation sigma factor SigK; Reviewed; Region: PRK05803 545693012451 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693012452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693012453 DNA binding residues [nucleotide binding] 545693012454 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 545693012455 YrhC-like protein; Region: YrhC; pfam14143 545693012456 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693012457 homodimer interface [polypeptide binding]; other site 545693012458 substrate-cofactor binding pocket; other site 545693012459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012460 catalytic residue [active] 545693012461 cysteine synthase; Region: PLN02565 545693012462 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 545693012463 dimer interface [polypeptide binding]; other site 545693012464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012465 catalytic residue [active] 545693012466 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 545693012467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 545693012468 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 545693012469 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 545693012470 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693012471 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 545693012472 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693012473 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 545693012474 catalytic triad [active] 545693012475 conserved cis-peptide bond; other site 545693012476 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 545693012477 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 545693012478 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 545693012479 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 545693012480 ATP-binding site [chemical binding]; other site 545693012481 Sugar specificity; other site 545693012482 Pyrimidine base specificity; other site 545693012483 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 545693012484 putative protease; Provisional; Region: PRK15452 545693012485 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 545693012486 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 545693012487 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 545693012488 dimerization interface [polypeptide binding]; other site 545693012489 hypothetical protein; Provisional; Region: PRK13678 545693012490 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 545693012491 hypothetical protein; Provisional; Region: PRK05473 545693012492 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 545693012493 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 545693012494 motif 1; other site 545693012495 active site 545693012496 motif 2; other site 545693012497 motif 3; other site 545693012498 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 545693012499 DHHA1 domain; Region: DHHA1; pfam02272 545693012500 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 545693012501 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 545693012502 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 545693012503 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 545693012504 AAA domain; Region: AAA_30; pfam13604 545693012505 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 545693012506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693012507 binding surface 545693012508 TPR motif; other site 545693012509 TPR repeat; Region: TPR_11; pfam13414 545693012510 TPR repeat; Region: TPR_11; pfam13414 545693012511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693012512 binding surface 545693012513 TPR motif; other site 545693012514 TPR repeat; Region: TPR_11; pfam13414 545693012515 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 545693012516 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 545693012517 Ligand Binding Site [chemical binding]; other site 545693012518 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 545693012519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693012520 catalytic residue [active] 545693012521 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693012522 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693012523 recombination factor protein RarA; Reviewed; Region: PRK13342 545693012524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012525 Walker A motif; other site 545693012526 ATP binding site [chemical binding]; other site 545693012527 Walker B motif; other site 545693012528 arginine finger; other site 545693012529 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 545693012530 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 545693012531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693012532 dimer interface [polypeptide binding]; other site 545693012533 conserved gate region; other site 545693012534 putative PBP binding loops; other site 545693012535 ABC-ATPase subunit interface; other site 545693012536 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 545693012537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693012538 dimer interface [polypeptide binding]; other site 545693012539 conserved gate region; other site 545693012540 putative PBP binding loops; other site 545693012541 ABC-ATPase subunit interface; other site 545693012542 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 545693012543 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 545693012544 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 545693012545 putative ATP binding site [chemical binding]; other site 545693012546 putative substrate interface [chemical binding]; other site 545693012547 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 545693012548 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 545693012549 dimer interface [polypeptide binding]; other site 545693012550 anticodon binding site; other site 545693012551 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 545693012552 homodimer interface [polypeptide binding]; other site 545693012553 motif 1; other site 545693012554 active site 545693012555 motif 2; other site 545693012556 GAD domain; Region: GAD; pfam02938 545693012557 motif 3; other site 545693012558 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 545693012559 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 545693012560 dimer interface [polypeptide binding]; other site 545693012561 motif 1; other site 545693012562 active site 545693012563 motif 2; other site 545693012564 motif 3; other site 545693012565 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 545693012566 anticodon binding site; other site 545693012567 Bacterial SH3 domain; Region: SH3_3; pfam08239 545693012568 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 545693012569 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693012570 active site 545693012571 metal binding site [ion binding]; metal-binding site 545693012572 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 545693012573 putative active site [active] 545693012574 dimerization interface [polypeptide binding]; other site 545693012575 putative tRNAtyr binding site [nucleotide binding]; other site 545693012576 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 545693012577 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693012578 Zn2+ binding site [ion binding]; other site 545693012579 Mg2+ binding site [ion binding]; other site 545693012580 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 545693012581 synthetase active site [active] 545693012582 NTP binding site [chemical binding]; other site 545693012583 metal binding site [ion binding]; metal-binding site 545693012584 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 545693012585 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 545693012586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693012587 active site 545693012588 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 545693012589 DHH family; Region: DHH; pfam01368 545693012590 DHHA1 domain; Region: DHHA1; pfam02272 545693012591 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 545693012592 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 545693012593 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 545693012594 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 545693012595 Protein export membrane protein; Region: SecD_SecF; pfam02355 545693012596 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 545693012597 stage V sporulation protein B; Region: spore_V_B; TIGR02900 545693012598 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 545693012599 Predicted membrane protein [Function unknown]; Region: COG2323 545693012600 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 545693012601 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 545693012602 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 545693012603 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 545693012604 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 545693012605 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 545693012606 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 545693012607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012608 Walker A motif; other site 545693012609 ATP binding site [chemical binding]; other site 545693012610 Walker B motif; other site 545693012611 arginine finger; other site 545693012612 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 545693012613 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 545693012614 RuvA N terminal domain; Region: RuvA_N; pfam01330 545693012615 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 545693012616 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 545693012617 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 545693012618 BofC C-terminal domain; Region: BofC_C; pfam08955 545693012619 Heat induced stress protein YflT; Region: YflT; pfam11181 545693012620 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 545693012621 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693012622 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 545693012623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693012624 Cellular tumor antigen p53-inducible 5; Region: TP53IP5; pfam15331 545693012625 quinolinate synthetase; Provisional; Region: PRK09375 545693012626 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 545693012627 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 545693012628 dimerization interface [polypeptide binding]; other site 545693012629 active site 545693012630 L-aspartate oxidase; Provisional; Region: PRK08071 545693012631 L-aspartate oxidase; Provisional; Region: PRK06175 545693012632 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 545693012633 putative cysteine desulfurase, frameshift 545693012634 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 545693012635 HTH domain; Region: HTH_11; pfam08279 545693012636 3H domain; Region: 3H; pfam02829 545693012637 prephenate dehydratase; Provisional; Region: PRK11898 545693012638 Prephenate dehydratase; Region: PDT; pfam00800 545693012639 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 545693012640 putative L-Phe binding site [chemical binding]; other site 545693012641 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 545693012642 hypothetical protein; Provisional; Region: PRK04435 545693012643 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 545693012644 GTPase CgtA; Reviewed; Region: obgE; PRK12297 545693012645 GTP1/OBG; Region: GTP1_OBG; pfam01018 545693012646 Obg GTPase; Region: Obg; cd01898 545693012647 G1 box; other site 545693012648 GTP/Mg2+ binding site [chemical binding]; other site 545693012649 Switch I region; other site 545693012650 G2 box; other site 545693012651 G3 box; other site 545693012652 Switch II region; other site 545693012653 G4 box; other site 545693012654 G5 box; other site 545693012655 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 545693012656 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 545693012657 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 545693012658 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 545693012659 Protein of unknown function (DUF464); Region: DUF464; pfam04327 545693012660 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 545693012661 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 545693012662 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 545693012663 homodimer interface [polypeptide binding]; other site 545693012664 oligonucleotide binding site [chemical binding]; other site 545693012665 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 545693012666 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 545693012667 Peptidase family M50; Region: Peptidase_M50; pfam02163 545693012668 active site 545693012669 putative substrate binding region [chemical binding]; other site 545693012670 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 545693012671 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693012672 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 545693012673 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 545693012674 P-loop; other site 545693012675 ADP binding residues [chemical binding]; other site 545693012676 Switch I; other site 545693012677 Switch II; other site 545693012678 septum formation inhibitor; Reviewed; Region: minC; PRK00513 545693012679 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 545693012680 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 545693012681 rod shape-determining protein MreC; Provisional; Region: PRK13922 545693012682 rod shape-determining protein MreB; Provisional; Region: PRK13927 545693012683 MreB and similar proteins; Region: MreB_like; cd10225 545693012684 nucleotide binding site [chemical binding]; other site 545693012685 Mg binding site [ion binding]; other site 545693012686 putative protofilament interaction site [polypeptide binding]; other site 545693012687 RodZ interaction site [polypeptide binding]; other site 545693012688 hypothetical protein; Reviewed; Region: PRK00024 545693012689 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 545693012690 MPN+ (JAMM) motif; other site 545693012691 Zinc-binding site [ion binding]; other site 545693012692 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 545693012693 active site 545693012694 dimer interface [polypeptide binding]; other site 545693012695 Sporulation related domain; Region: SPOR; pfam05036 545693012696 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 545693012697 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 545693012698 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 545693012699 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 545693012700 Predicted membrane protein [Function unknown]; Region: COG2322 545693012701 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 545693012702 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693012703 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693012704 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 545693012705 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 545693012706 active site 545693012707 HIGH motif; other site 545693012708 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 545693012709 KMSKS motif; other site 545693012710 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 545693012711 tRNA binding surface [nucleotide binding]; other site 545693012712 anticodon binding site; other site 545693012713 Prefoldin subunit; Region: Prefoldin_2; pfam01920 545693012714 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 545693012715 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 545693012716 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 545693012717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693012718 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 545693012719 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693012720 inhibitor-cofactor binding pocket; inhibition site 545693012721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012722 catalytic residue [active] 545693012723 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 545693012724 dimer interface [polypeptide binding]; other site 545693012725 active site 545693012726 Schiff base residues; other site 545693012727 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 545693012728 active site 545693012729 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 545693012730 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 545693012731 domain interfaces; other site 545693012732 active site 545693012733 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 545693012734 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 545693012735 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 545693012736 tRNA; other site 545693012737 putative tRNA binding site [nucleotide binding]; other site 545693012738 putative NADP binding site [chemical binding]; other site 545693012739 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 545693012740 Predicted GTPase [General function prediction only]; Region: COG0218 545693012741 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 545693012742 G1 box; other site 545693012743 GTP/Mg2+ binding site [chemical binding]; other site 545693012744 Switch I region; other site 545693012745 G2 box; other site 545693012746 G3 box; other site 545693012747 Switch II region; other site 545693012748 G4 box; other site 545693012749 G5 box; other site 545693012750 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 545693012751 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 545693012752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012753 Walker A motif; other site 545693012754 ATP binding site [chemical binding]; other site 545693012755 Walker B motif; other site 545693012756 arginine finger; other site 545693012757 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 545693012758 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 545693012759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012760 Walker A motif; other site 545693012761 ATP binding site [chemical binding]; other site 545693012762 Walker B motif; other site 545693012763 arginine finger; other site 545693012764 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 545693012765 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 545693012766 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 545693012767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012768 Walker A motif; other site 545693012769 ATP binding site [chemical binding]; other site 545693012770 Walker B motif; other site 545693012771 arginine finger; other site 545693012772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 545693012773 trigger factor; Provisional; Region: tig; PRK01490 545693012774 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 545693012775 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 545693012776 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 545693012777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693012778 binding surface 545693012779 TPR motif; other site 545693012780 Tetratricopeptide repeat; Region: TPR_19; pfam14559 545693012781 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 545693012782 substrate binding site [chemical binding]; other site 545693012783 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 545693012784 substrate binding site [chemical binding]; other site 545693012785 ligand binding site [chemical binding]; other site 545693012786 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 545693012787 2-isopropylmalate synthase; Validated; Region: PRK00915 545693012788 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 545693012789 active site 545693012790 catalytic residues [active] 545693012791 metal binding site [ion binding]; metal-binding site 545693012792 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 545693012793 ketol-acid reductoisomerase; Provisional; Region: PRK05479 545693012794 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 545693012795 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 545693012796 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 545693012797 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 545693012798 putative valine binding site [chemical binding]; other site 545693012799 dimer interface [polypeptide binding]; other site 545693012800 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 545693012801 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 545693012802 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693012803 PYR/PP interface [polypeptide binding]; other site 545693012804 dimer interface [polypeptide binding]; other site 545693012805 TPP binding site [chemical binding]; other site 545693012806 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 545693012807 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 545693012808 TPP-binding site [chemical binding]; other site 545693012809 dimer interface [polypeptide binding]; other site 545693012810 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 545693012811 active site 545693012812 metal binding site [ion binding]; metal-binding site 545693012813 homotetramer interface [polypeptide binding]; other site 545693012814 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 545693012815 active site 545693012816 dimerization interface [polypeptide binding]; other site 545693012817 ribonuclease PH; Reviewed; Region: rph; PRK00173 545693012818 Ribonuclease PH; Region: RNase_PH_bact; cd11362 545693012819 hexamer interface [polypeptide binding]; other site 545693012820 active site 545693012821 Spore germination protein [General function prediction only]; Region: COG5401 545693012822 Sporulation and spore germination; Region: Germane; pfam10646 545693012823 Sporulation and spore germination; Region: Germane; pfam10646 545693012824 glutamate racemase; Provisional; Region: PRK00865 545693012825 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693012826 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693012827 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 545693012828 pentamer interface [polypeptide binding]; other site 545693012829 dodecaamer interface [polypeptide binding]; other site 545693012830 YvbH-like oligomerization region; Region: YvbH_ext; pfam11724 545693012831 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 545693012832 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 545693012833 TIGR00153 family protein; Region: TIGR00153 545693012834 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 545693012835 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 545693012836 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 545693012837 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 545693012838 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693012839 active site 545693012840 dimer interface [polypeptide binding]; other site 545693012841 non-prolyl cis peptide bond; other site 545693012842 insertion regions; other site 545693012843 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693012844 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693012845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693012846 dimer interface [polypeptide binding]; other site 545693012847 conserved gate region; other site 545693012848 putative PBP binding loops; other site 545693012849 ABC-ATPase subunit interface; other site 545693012850 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 545693012851 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 545693012852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693012853 substrate binding pocket [chemical binding]; other site 545693012854 membrane-bound complex binding site; other site 545693012855 hinge residues; other site 545693012856 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693012857 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 545693012858 Walker A/P-loop; other site 545693012859 ATP binding site [chemical binding]; other site 545693012860 Q-loop/lid; other site 545693012861 ABC transporter signature motif; other site 545693012862 Walker B; other site 545693012863 D-loop; other site 545693012864 H-loop/switch region; other site 545693012865 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 545693012866 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 545693012867 TrkA-C domain; Region: TrkA_C; pfam02080 545693012868 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693012869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693012870 DNA binding residues [nucleotide binding] 545693012871 dimerization interface [polypeptide binding]; other site 545693012872 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693012873 active site 545693012874 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 545693012875 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 545693012876 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 545693012877 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 545693012878 L-aspartate oxidase; Provisional; Region: PRK06175 545693012879 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 545693012880 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 545693012881 putative Iron-sulfur protein interface [polypeptide binding]; other site 545693012882 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 545693012883 proximal heme binding site [chemical binding]; other site 545693012884 distal heme binding site [chemical binding]; other site 545693012885 putative dimer interface [polypeptide binding]; other site 545693012886 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 545693012887 aspartate kinase; Reviewed; Region: PRK06635 545693012888 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 545693012889 putative nucleotide binding site [chemical binding]; other site 545693012890 putative catalytic residues [active] 545693012891 putative Mg ion binding site [ion binding]; other site 545693012892 putative aspartate binding site [chemical binding]; other site 545693012893 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 545693012894 putative allosteric regulatory site; other site 545693012895 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 545693012896 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 545693012897 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 545693012898 GIY-YIG motif/motif A; other site 545693012899 active site 545693012900 catalytic site [active] 545693012901 putative DNA binding site [nucleotide binding]; other site 545693012902 metal binding site [ion binding]; metal-binding site 545693012903 UvrB/uvrC motif; Region: UVR; pfam02151 545693012904 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 545693012905 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 545693012906 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693012907 catalytic residues [active] 545693012908 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 545693012909 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 545693012910 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 545693012911 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 545693012912 Ligand binding site [chemical binding]; other site 545693012913 enoyl-CoA hydratase; Provisional; Region: PRK07658 545693012914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693012915 substrate binding site [chemical binding]; other site 545693012916 oxyanion hole (OAH) forming residues; other site 545693012917 trimer interface [polypeptide binding]; other site 545693012918 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 545693012919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693012920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693012921 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 545693012922 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 545693012923 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 545693012924 acyl-activating enzyme (AAE) consensus motif; other site 545693012925 putative AMP binding site [chemical binding]; other site 545693012926 putative active site [active] 545693012927 putative CoA binding site [chemical binding]; other site 545693012928 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 545693012929 substrate binding site [chemical binding]; other site 545693012930 THF binding site; other site 545693012931 zinc-binding site [ion binding]; other site 545693012932 Predicted membrane protein [Function unknown]; Region: COG3766 545693012933 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693012934 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693012935 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 545693012936 MutS domain III; Region: MutS_III; pfam05192 545693012937 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 545693012938 Walker A/P-loop; other site 545693012939 ATP binding site [chemical binding]; other site 545693012940 Q-loop/lid; other site 545693012941 ABC transporter signature motif; other site 545693012942 Walker B; other site 545693012943 D-loop; other site 545693012944 H-loop/switch region; other site 545693012945 Smr domain; Region: Smr; pfam01713 545693012946 hypothetical protein; Provisional; Region: PRK08609 545693012947 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 545693012948 active site 545693012949 primer binding site [nucleotide binding]; other site 545693012950 NTP binding site [chemical binding]; other site 545693012951 metal binding triad [ion binding]; metal-binding site 545693012952 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 545693012953 active site 545693012954 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 545693012955 Cell division protein ZapA; Region: ZapA; cl01146 545693012956 ribonuclease HIII; Provisional; Region: PRK00996 545693012957 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 545693012958 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 545693012959 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693012960 active site 545693012961 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 545693012962 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 545693012963 putative tRNA-binding site [nucleotide binding]; other site 545693012964 B3/4 domain; Region: B3_4; pfam03483 545693012965 tRNA synthetase B5 domain; Region: B5; smart00874 545693012966 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 545693012967 dimer interface [polypeptide binding]; other site 545693012968 motif 1; other site 545693012969 motif 3; other site 545693012970 motif 2; other site 545693012971 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 545693012972 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 545693012973 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 545693012974 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 545693012975 dimer interface [polypeptide binding]; other site 545693012976 motif 1; other site 545693012977 active site 545693012978 motif 2; other site 545693012979 motif 3; other site 545693012980 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 545693012981 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 545693012982 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 545693012983 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 545693012984 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 545693012985 oligomer interface [polypeptide binding]; other site 545693012986 active site 545693012987 metal binding site [ion binding]; metal-binding site 545693012988 dUTPase; Region: dUTPase_2; pfam08761 545693012989 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 545693012990 active site 545693012991 homodimer interface [polypeptide binding]; other site 545693012992 metal binding site [ion binding]; metal-binding site 545693012993 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 545693012994 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 545693012995 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 545693012996 23S rRNA binding site [nucleotide binding]; other site 545693012997 L21 binding site [polypeptide binding]; other site 545693012998 L13 binding site [polypeptide binding]; other site 545693012999 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 545693013000 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 545693013001 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 545693013002 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 545693013003 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 545693013004 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 545693013005 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 545693013006 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 545693013007 active site 545693013008 dimer interface [polypeptide binding]; other site 545693013009 motif 1; other site 545693013010 motif 2; other site 545693013011 motif 3; other site 545693013012 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 545693013013 anticodon binding site; other site 545693013014 YtxC-like family; Region: YtxC; cl08500 545693013015 primosomal protein DnaI; Reviewed; Region: PRK08939 545693013016 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 545693013017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693013018 Walker A motif; other site 545693013019 ATP binding site [chemical binding]; other site 545693013020 Walker B motif; other site 545693013021 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 545693013022 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 545693013023 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 545693013024 ATP cone domain; Region: ATP-cone; pfam03477 545693013025 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 545693013026 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 545693013027 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 545693013028 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 545693013029 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 545693013030 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 545693013031 CoA-binding site [chemical binding]; other site 545693013032 ATP-binding [chemical binding]; other site 545693013033 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 545693013034 Domain of unknown function DUF; Region: DUF204; pfam02659 545693013035 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 545693013036 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 545693013037 DNA binding site [nucleotide binding] 545693013038 catalytic residue [active] 545693013039 H2TH interface [polypeptide binding]; other site 545693013040 putative catalytic residues [active] 545693013041 turnover-facilitating residue; other site 545693013042 intercalation triad [nucleotide binding]; other site 545693013043 8OG recognition residue [nucleotide binding]; other site 545693013044 putative reading head residues; other site 545693013045 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 545693013046 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 545693013047 DNA polymerase I; Provisional; Region: PRK05755 545693013048 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 545693013049 active site 545693013050 metal binding site 1 [ion binding]; metal-binding site 545693013051 putative 5' ssDNA interaction site; other site 545693013052 metal binding site 3; metal-binding site 545693013053 metal binding site 2 [ion binding]; metal-binding site 545693013054 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 545693013055 putative DNA binding site [nucleotide binding]; other site 545693013056 putative metal binding site [ion binding]; other site 545693013057 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 545693013058 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 545693013059 active site 545693013060 DNA binding site [nucleotide binding] 545693013061 catalytic site [active] 545693013062 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 545693013063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693013064 dimerization interface [polypeptide binding]; other site 545693013065 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693013066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693013067 putative active site [active] 545693013068 heme pocket [chemical binding]; other site 545693013069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693013070 dimer interface [polypeptide binding]; other site 545693013071 phosphorylation site [posttranslational modification] 545693013072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693013073 ATP binding site [chemical binding]; other site 545693013074 Mg2+ binding site [ion binding]; other site 545693013075 G-X-G motif; other site 545693013076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693013077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013078 active site 545693013079 phosphorylation site [posttranslational modification] 545693013080 intermolecular recognition site; other site 545693013081 dimerization interface [polypeptide binding]; other site 545693013082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693013083 DNA binding site [nucleotide binding] 545693013084 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 545693013085 active site 2 [active] 545693013086 active site 1 [active] 545693013087 malate dehydrogenase; Reviewed; Region: PRK06223 545693013088 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 545693013089 NAD(P) binding site [chemical binding]; other site 545693013090 dimer interface [polypeptide binding]; other site 545693013091 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693013092 substrate binding site [chemical binding]; other site 545693013093 isocitrate dehydrogenase; Reviewed; Region: PRK07006 545693013094 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 545693013095 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 545693013096 dimer interface [polypeptide binding]; other site 545693013097 active site 545693013098 citrylCoA binding site [chemical binding]; other site 545693013099 oxalacetate/citrate binding site [chemical binding]; other site 545693013100 coenzyme A binding site [chemical binding]; other site 545693013101 catalytic triad [active] 545693013102 Protein of unknown function (DUF441); Region: DUF441; pfam04284 545693013103 Domain of unknown function DUF20; Region: UPF0118; cl00465 545693013104 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 545693013105 pyruvate kinase; Provisional; Region: PRK06354 545693013106 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 545693013107 domain interfaces; other site 545693013108 active site 545693013109 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 545693013110 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 545693013111 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 545693013112 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693013113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693013114 DNA-binding site [nucleotide binding]; DNA binding site 545693013115 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 545693013116 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693013117 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 545693013118 putative NAD(P) binding site [chemical binding]; other site 545693013119 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 545693013120 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 545693013121 active site 545693013122 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 545693013123 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 545693013124 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 545693013125 generic binding surface I; other site 545693013126 generic binding surface II; other site 545693013127 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 545693013128 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 545693013129 DHH family; Region: DHH; pfam01368 545693013130 DHHA1 domain; Region: DHHA1; pfam02272 545693013131 YtpI-like protein; Region: YtpI; pfam14007 545693013132 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 545693013133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 545693013134 DNA-binding site [nucleotide binding]; DNA binding site 545693013135 DRTGG domain; Region: DRTGG; pfam07085 545693013136 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 545693013137 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 545693013138 active site 2 [active] 545693013139 active site 1 [active] 545693013140 metal-dependent hydrolase; Provisional; Region: PRK00685 545693013141 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 545693013142 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 545693013143 hexamer interface [polypeptide binding]; other site 545693013144 ligand binding site [chemical binding]; other site 545693013145 putative active site [active] 545693013146 NAD(P) binding site [chemical binding]; other site 545693013147 argininosuccinate lyase; Provisional; Region: PRK00855 545693013148 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 545693013149 active sites [active] 545693013150 tetramer interface [polypeptide binding]; other site 545693013151 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 545693013152 ANP binding site [chemical binding]; other site 545693013153 Substrate Binding Site II [chemical binding]; other site 545693013154 Substrate Binding Site I [chemical binding]; other site 545693013155 EcsC protein family; Region: EcsC; pfam12787 545693013156 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 545693013157 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 545693013158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693013159 S-adenosylmethionine binding site [chemical binding]; other site 545693013160 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 545693013161 dimer interface [polypeptide binding]; other site 545693013162 catalytic triad [active] 545693013163 peroxidatic and resolving cysteines [active] 545693013164 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 545693013165 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 545693013166 RDD family; Region: RDD; pfam06271 545693013167 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 545693013168 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 545693013169 tandem repeat interface [polypeptide binding]; other site 545693013170 oligomer interface [polypeptide binding]; other site 545693013171 active site residues [active] 545693013172 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 545693013173 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 545693013174 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 545693013175 active site 545693013176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693013177 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 545693013178 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 545693013179 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 545693013180 Ligand Binding Site [chemical binding]; other site 545693013181 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 545693013182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693013183 catalytic residue [active] 545693013184 septation ring formation regulator EzrA; Provisional; Region: PRK04778 545693013185 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 545693013186 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 545693013187 active site 545693013188 dimer interface [polypeptide binding]; other site 545693013189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693013190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693013191 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 545693013192 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 545693013193 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 545693013194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693013195 RNA binding surface [nucleotide binding]; other site 545693013196 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 545693013197 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 545693013198 active site 545693013199 HIGH motif; other site 545693013200 dimer interface [polypeptide binding]; other site 545693013201 KMSKS motif; other site 545693013202 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693013203 RNA binding surface [nucleotide binding]; other site 545693013204 acetyl-CoA synthetase; Provisional; Region: PRK04319 545693013205 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 545693013206 active site 545693013207 acyl-activating enzyme (AAE) consensus motif; other site 545693013208 putative CoA binding site [chemical binding]; other site 545693013209 AMP binding site [chemical binding]; other site 545693013210 FOG: CBS domain [General function prediction only]; Region: COG0517 545693013211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 545693013212 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 545693013213 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 545693013214 active site 545693013215 Zn binding site [ion binding]; other site 545693013216 flagellar motor protein MotS; Reviewed; Region: PRK06925 545693013217 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 545693013218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 545693013219 ligand binding site [chemical binding]; other site 545693013220 flagellar motor protein MotP; Reviewed; Region: PRK06926 545693013221 catabolite control protein A; Region: ccpA; TIGR01481 545693013222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693013223 DNA binding site [nucleotide binding] 545693013224 domain linker motif; other site 545693013225 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 545693013226 dimerization interface [polypeptide binding]; other site 545693013227 effector binding site; other site 545693013228 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 545693013229 Chorismate mutase type II; Region: CM_2; cl00693 545693013230 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 545693013231 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 545693013232 YtxH-like protein; Region: YtxH; cl02079 545693013233 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 545693013234 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 545693013235 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 545693013236 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693013237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693013238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693013239 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693013240 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 545693013241 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 545693013242 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 545693013243 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 545693013244 putative tRNA-binding site [nucleotide binding]; other site 545693013245 hypothetical protein; Provisional; Region: PRK13668 545693013246 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693013247 catalytic residues [active] 545693013248 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 545693013249 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 545693013250 oligomer interface [polypeptide binding]; other site 545693013251 active site 545693013252 metal binding site [ion binding]; metal-binding site 545693013253 Predicted small secreted protein [Function unknown]; Region: COG5584 545693013254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 545693013255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693013256 S-adenosylmethionine binding site [chemical binding]; other site 545693013257 YtzH-like protein; Region: YtzH; pfam14165 545693013258 Phosphotransferase enzyme family; Region: APH; pfam01636 545693013259 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 545693013260 active site 545693013261 substrate binding site [chemical binding]; other site 545693013262 ATP binding site [chemical binding]; other site 545693013263 Ecdysteroid kinase; Region: EcKinase; cl17738 545693013264 pullulanase, type I; Region: pulA_typeI; TIGR02104 545693013265 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 545693013266 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 545693013267 Ca binding site [ion binding]; other site 545693013268 active site 545693013269 catalytic site [active] 545693013270 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 545693013271 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 545693013272 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 545693013273 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 545693013274 cysteine synthase; Region: PLN02565 545693013275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 545693013276 dimer interface [polypeptide binding]; other site 545693013277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693013278 catalytic residue [active] 545693013279 dipeptidase PepV; Reviewed; Region: PRK07318 545693013280 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 545693013281 active site 545693013282 metal binding site [ion binding]; metal-binding site 545693013283 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 545693013284 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 545693013285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693013286 RNA binding surface [nucleotide binding]; other site 545693013287 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 545693013288 active site 545693013289 uracil binding [chemical binding]; other site 545693013290 stage V sporulation protein B; Region: spore_V_B; TIGR02900 545693013291 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 545693013292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693013293 HI0933-like protein; Region: HI0933_like; pfam03486 545693013294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693013295 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 545693013296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693013297 active site residue [active] 545693013298 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 545693013299 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 545693013300 active site 545693013301 HIGH motif; other site 545693013302 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 545693013303 KMSKS motif; other site 545693013304 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 545693013305 tRNA binding surface [nucleotide binding]; other site 545693013306 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 545693013307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693013308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693013309 putative substrate translocation pore; other site 545693013310 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 545693013311 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 545693013312 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 545693013313 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693013314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693013315 S-adenosylmethionine binding site [chemical binding]; other site 545693013316 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 545693013317 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693013318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693013319 Serine hydrolase; Region: Ser_hydrolase; cl17834 545693013320 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 545693013321 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 545693013322 trimer interface [polypeptide binding]; other site 545693013323 putative metal binding site [ion binding]; other site 545693013324 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 545693013325 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693013326 active site 545693013327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693013328 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 545693013329 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 545693013330 S-adenosylmethionine synthetase; Validated; Region: PRK05250 545693013331 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 545693013332 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 545693013333 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 545693013334 active site 545693013335 substrate-binding site [chemical binding]; other site 545693013336 metal-binding site [ion binding] 545693013337 ATP binding site [chemical binding]; other site 545693013338 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 545693013339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693013340 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693013341 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 545693013342 NMT1-like family; Region: NMT1_2; pfam13379 545693013343 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693013344 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 545693013345 Walker A/P-loop; other site 545693013346 ATP binding site [chemical binding]; other site 545693013347 Q-loop/lid; other site 545693013348 ABC transporter signature motif; other site 545693013349 Walker B; other site 545693013350 D-loop; other site 545693013351 H-loop/switch region; other site 545693013352 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693013353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693013354 dimer interface [polypeptide binding]; other site 545693013355 conserved gate region; other site 545693013356 putative PBP binding loops; other site 545693013357 ABC-ATPase subunit interface; other site 545693013358 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 545693013359 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 545693013360 nudix motif; other site 545693013361 Holin family; Region: Phage_holin_4; cl01989 545693013362 Ferritin-like domain; Region: Ferritin; pfam00210 545693013363 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 545693013364 dimerization interface [polypeptide binding]; other site 545693013365 DPS ferroxidase diiron center [ion binding]; other site 545693013366 ion pore; other site 545693013367 S-ribosylhomocysteinase; Provisional; Region: PRK02260 545693013368 hypothetical protein; Validated; Region: PRK00041 545693013369 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 545693013370 active site clefts [active] 545693013371 zinc binding site [ion binding]; other site 545693013372 dimer interface [polypeptide binding]; other site 545693013373 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 545693013374 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 545693013375 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 545693013376 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 545693013377 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 545693013378 metal binding site [ion binding]; metal-binding site 545693013379 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 545693013380 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 545693013381 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 545693013382 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 545693013383 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 545693013384 flavodoxin, short chain; Region: flav_short; TIGR01753 545693013385 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 545693013386 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 545693013387 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 545693013388 dimer interface [polypeptide binding]; other site 545693013389 putative radical transfer pathway; other site 545693013390 diiron center [ion binding]; other site 545693013391 tyrosyl radical; other site 545693013392 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 545693013393 Class I ribonucleotide reductase; Region: RNR_I; cd01679 545693013394 active site 545693013395 dimer interface [polypeptide binding]; other site 545693013396 catalytic residues [active] 545693013397 effector binding site; other site 545693013398 R2 peptide binding site; other site 545693013399 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 545693013400 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 545693013401 active site 545693013402 octamer interface [polypeptide binding]; other site 545693013403 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 545693013404 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 545693013405 acyl-activating enzyme (AAE) consensus motif; other site 545693013406 putative AMP binding site [chemical binding]; other site 545693013407 putative active site [active] 545693013408 putative CoA binding site [chemical binding]; other site 545693013409 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 545693013410 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693013411 substrate binding site [chemical binding]; other site 545693013412 oxyanion hole (OAH) forming residues; other site 545693013413 trimer interface [polypeptide binding]; other site 545693013414 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 545693013415 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693013416 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 545693013417 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 545693013418 dimer interface [polypeptide binding]; other site 545693013419 tetramer interface [polypeptide binding]; other site 545693013420 PYR/PP interface [polypeptide binding]; other site 545693013421 TPP binding site [chemical binding]; other site 545693013422 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 545693013423 TPP-binding site; other site 545693013424 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 545693013425 isochorismate synthases; Region: isochor_syn; TIGR00543 545693013426 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 545693013427 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 545693013428 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 545693013429 homodimer interface [polypeptide binding]; other site 545693013430 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 545693013431 active site pocket [active] 545693013432 glycogen synthase; Provisional; Region: glgA; PRK00654 545693013433 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 545693013434 ADP-binding pocket [chemical binding]; other site 545693013435 homodimer interface [polypeptide binding]; other site 545693013436 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 545693013437 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 545693013438 ligand binding site; other site 545693013439 oligomer interface; other site 545693013440 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 545693013441 dimer interface [polypeptide binding]; other site 545693013442 N-terminal domain interface [polypeptide binding]; other site 545693013443 sulfate 1 binding site; other site 545693013444 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 545693013445 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 545693013446 ligand binding site; other site 545693013447 oligomer interface; other site 545693013448 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 545693013449 dimer interface [polypeptide binding]; other site 545693013450 N-terminal domain interface [polypeptide binding]; other site 545693013451 sulfate 1 binding site; other site 545693013452 glycogen branching enzyme; Provisional; Region: PRK12313 545693013453 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 545693013454 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 545693013455 active site 545693013456 catalytic site [active] 545693013457 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 545693013458 AMP-binding domain protein; Validated; Region: PRK08315 545693013459 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 545693013460 acyl-activating enzyme (AAE) consensus motif; other site 545693013461 putative AMP binding site [chemical binding]; other site 545693013462 putative active site [active] 545693013463 putative CoA binding site [chemical binding]; other site 545693013464 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 545693013465 MgtC family; Region: MgtC; pfam02308 545693013466 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 545693013467 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 545693013468 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 545693013469 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 545693013470 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 545693013471 putative active site [active] 545693013472 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 545693013473 putative active site [active] 545693013474 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 545693013475 active site 545693013476 SAM binding site [chemical binding]; other site 545693013477 homodimer interface [polypeptide binding]; other site 545693013478 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 545693013479 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 545693013480 ligand-binding site [chemical binding]; other site 545693013481 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 545693013482 ATP-sulfurylase; Region: ATPS; cd00517 545693013483 active site 545693013484 HXXH motif; other site 545693013485 flexible loop; other site 545693013486 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 545693013487 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 545693013488 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 545693013489 Active Sites [active] 545693013490 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 545693013491 Uncharacterized conserved protein [Function unknown]; Region: COG1624 545693013492 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 545693013493 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693013494 active site 545693013495 metal binding site [ion binding]; metal-binding site 545693013496 Ion channel; Region: Ion_trans_2; pfam07885 545693013497 TrkA-N domain; Region: TrkA_N; pfam02254 545693013498 YugN-like family; Region: YugN; pfam08868 545693013499 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 545693013500 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 545693013501 active site 545693013502 dimer interface [polypeptide binding]; other site 545693013503 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 545693013504 dimer interface [polypeptide binding]; other site 545693013505 active site 545693013506 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 545693013507 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 545693013508 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 545693013509 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 545693013510 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 545693013511 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 545693013512 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 545693013513 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 545693013514 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 545693013515 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 545693013516 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 545693013517 dimer interface [polypeptide binding]; other site 545693013518 active site 545693013519 metal binding site [ion binding]; metal-binding site 545693013520 Domain of unknown function (DUF378); Region: DUF378; pfam04070 545693013521 general stress protein 13; Validated; Region: PRK08059 545693013522 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693013523 RNA binding site [nucleotide binding]; other site 545693013524 aspartate aminotransferase; Provisional; Region: PRK05764 545693013525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693013526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693013527 homodimer interface [polypeptide binding]; other site 545693013528 catalytic residue [active] 545693013529 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693013530 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 545693013531 AsnC family; Region: AsnC_trans_reg; pfam01037 545693013532 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693013533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693013534 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 545693013535 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 545693013536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693013537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693013538 homodimer interface [polypeptide binding]; other site 545693013539 catalytic residue [active] 545693013540 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 545693013541 E-class dimer interface [polypeptide binding]; other site 545693013542 P-class dimer interface [polypeptide binding]; other site 545693013543 active site 545693013544 Cu2+ binding site [ion binding]; other site 545693013545 Zn2+ binding site [ion binding]; other site 545693013546 Kinase associated protein B; Region: KapB; pfam08810 545693013547 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 545693013548 active site 545693013549 catalytic site [active] 545693013550 substrate binding site [chemical binding]; other site 545693013551 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 545693013552 CoenzymeA binding site [chemical binding]; other site 545693013553 subunit interaction site [polypeptide binding]; other site 545693013554 PHB binding site; other site 545693013555 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 545693013556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693013557 Zn2+ binding site [ion binding]; other site 545693013558 Mg2+ binding site [ion binding]; other site 545693013559 Predicted permease [General function prediction only]; Region: COG2056 545693013560 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 545693013561 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 545693013562 multifunctional aminopeptidase A; Provisional; Region: PRK00913 545693013563 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 545693013564 interface (dimer of trimers) [polypeptide binding]; other site 545693013565 Substrate-binding/catalytic site; other site 545693013566 Zn-binding sites [ion binding]; other site 545693013567 Divergent PAP2 family; Region: DUF212; pfam02681 545693013568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 545693013569 Putative membrane protein; Region: YuiB; pfam14068 545693013570 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 545693013571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693013572 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693013573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693013574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693013575 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 545693013576 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 545693013577 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 545693013578 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 545693013579 hypothetical protein; Provisional; Region: PRK13669 545693013580 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 545693013581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693013582 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 545693013583 NifU-like domain; Region: NifU; pfam01106 545693013584 homoserine kinase; Provisional; Region: PRK01212 545693013585 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 545693013586 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 545693013587 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 545693013588 homodimer interface [polypeptide binding]; other site 545693013589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693013590 catalytic residue [active] 545693013591 homoserine dehydrogenase; Provisional; Region: PRK06349 545693013592 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 545693013593 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 545693013594 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 545693013595 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 545693013596 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 545693013597 dimerization interface [polypeptide binding]; other site 545693013598 ligand binding site [chemical binding]; other site 545693013599 NADP binding site [chemical binding]; other site 545693013600 catalytic site [active] 545693013601 spore coat protein YutH; Region: spore_yutH; TIGR02905 545693013602 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 545693013603 tetramer interfaces [polypeptide binding]; other site 545693013604 binuclear metal-binding site [ion binding]; other site 545693013605 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 545693013606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013607 active site 545693013608 motif I; other site 545693013609 motif II; other site 545693013610 Uncharacterized conserved protein [Function unknown]; Region: COG2445 545693013611 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 545693013612 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 545693013613 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693013614 lipoyl synthase; Provisional; Region: PRK05481 545693013615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693013616 FeS/SAM binding site; other site 545693013617 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 545693013618 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693013619 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 545693013620 Na2 binding site [ion binding]; other site 545693013621 putative substrate binding site 1 [chemical binding]; other site 545693013622 Na binding site 1 [ion binding]; other site 545693013623 putative substrate binding site 2 [chemical binding]; other site 545693013624 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 545693013625 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 545693013626 Uncharacterized conserved protein [Function unknown]; Region: COG1801 545693013627 FeS assembly protein SufB; Region: sufB; TIGR01980 545693013628 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 545693013629 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 545693013630 trimerization site [polypeptide binding]; other site 545693013631 active site 545693013632 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 545693013633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693013634 catalytic residue [active] 545693013635 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 545693013636 FeS assembly protein SufD; Region: sufD; TIGR01981 545693013637 FeS assembly ATPase SufC; Region: sufC; TIGR01978 545693013638 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 545693013639 Walker A/P-loop; other site 545693013640 ATP binding site [chemical binding]; other site 545693013641 Q-loop/lid; other site 545693013642 ABC transporter signature motif; other site 545693013643 Walker B; other site 545693013644 D-loop; other site 545693013645 H-loop/switch region; other site 545693013646 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 545693013647 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 545693013648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693013649 dimer interface [polypeptide binding]; other site 545693013650 conserved gate region; other site 545693013651 putative PBP binding loops; other site 545693013652 ABC-ATPase subunit interface; other site 545693013653 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 545693013654 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 545693013655 Walker A/P-loop; other site 545693013656 ATP binding site [chemical binding]; other site 545693013657 Q-loop/lid; other site 545693013658 ABC transporter signature motif; other site 545693013659 Walker B; other site 545693013660 D-loop; other site 545693013661 H-loop/switch region; other site 545693013662 NIL domain; Region: NIL; pfam09383 545693013663 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693013664 catalytic residues [active] 545693013665 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 545693013666 putative active site [active] 545693013667 putative metal binding site [ion binding]; other site 545693013668 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 545693013669 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 545693013670 lipoyl attachment site [posttranslational modification]; other site 545693013671 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 545693013672 putative ArsC-like catalytic residues; other site 545693013673 putative TRX-like catalytic residues [active] 545693013674 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693013675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693013676 active site 545693013677 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 545693013678 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693013679 dimer interface [polypeptide binding]; other site 545693013680 active site 545693013681 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 545693013682 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 545693013683 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693013684 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693013685 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 545693013686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693013687 substrate binding site [chemical binding]; other site 545693013688 oxyanion hole (OAH) forming residues; other site 545693013689 trimer interface [polypeptide binding]; other site 545693013690 YuzL-like protein; Region: YuzL; pfam14115 545693013691 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 545693013692 Proline dehydrogenase; Region: Pro_dh; pfam01619 545693013693 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 545693013694 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 545693013695 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 545693013696 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 545693013697 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693013698 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693013699 Walker A/P-loop; other site 545693013700 ATP binding site [chemical binding]; other site 545693013701 Q-loop/lid; other site 545693013702 ABC transporter signature motif; other site 545693013703 Walker B; other site 545693013704 D-loop; other site 545693013705 H-loop/switch region; other site 545693013706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693013707 ABC-ATPase subunit interface; other site 545693013708 dimer interface [polypeptide binding]; other site 545693013709 putative PBP binding regions; other site 545693013710 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693013711 ABC-ATPase subunit interface; other site 545693013712 dimer interface [polypeptide binding]; other site 545693013713 putative PBP binding regions; other site 545693013714 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 545693013715 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 545693013716 siderophore binding site; other site 545693013717 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 545693013718 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 545693013719 MMPL family; Region: MMPL; cl14618 545693013720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693013721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693013722 Protein of unknown function (DUF502); Region: DUF502; cl01107 545693013723 short chain dehydrogenase; Validated; Region: PRK08589 545693013724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013725 benzoate transport; Region: 2A0115; TIGR00895 545693013726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693013727 putative substrate translocation pore; other site 545693013728 azoreductase; Provisional; Region: PRK13556 545693013729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693013730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693013731 dimerization interface [polypeptide binding]; other site 545693013732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693013733 dimer interface [polypeptide binding]; other site 545693013734 phosphorylation site [posttranslational modification] 545693013735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693013736 ATP binding site [chemical binding]; other site 545693013737 Mg2+ binding site [ion binding]; other site 545693013738 G-X-G motif; other site 545693013739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693013740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013741 active site 545693013742 phosphorylation site [posttranslational modification] 545693013743 intermolecular recognition site; other site 545693013744 dimerization interface [polypeptide binding]; other site 545693013745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693013746 DNA binding site [nucleotide binding] 545693013747 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 545693013748 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 545693013749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693013750 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693013751 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 545693013752 active site 545693013753 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693013754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693013755 putative DNA binding site [nucleotide binding]; other site 545693013756 putative Zn2+ binding site [ion binding]; other site 545693013757 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 545693013758 dimer interface [polypeptide binding]; other site 545693013759 FMN binding site [chemical binding]; other site 545693013760 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 545693013761 MoaE interaction surface [polypeptide binding]; other site 545693013762 MoeB interaction surface [polypeptide binding]; other site 545693013763 thiocarboxylated glycine; other site 545693013764 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 545693013765 MoaE homodimer interface [polypeptide binding]; other site 545693013766 MoaD interaction [polypeptide binding]; other site 545693013767 active site residues [active] 545693013768 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 545693013769 Walker A motif; other site 545693013770 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 545693013771 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 545693013772 dimer interface [polypeptide binding]; other site 545693013773 putative functional site; other site 545693013774 putative MPT binding site; other site 545693013775 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 545693013776 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 545693013777 ATP binding site [chemical binding]; other site 545693013778 substrate interface [chemical binding]; other site 545693013779 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 545693013780 GTP binding site; other site 545693013781 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 545693013782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693013783 FeS/SAM binding site; other site 545693013784 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 545693013785 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 545693013786 Uncharacterized conserved protein [Function unknown]; Region: COG5609 545693013787 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 545693013788 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 545693013789 catalytic loop [active] 545693013790 iron binding site [ion binding]; other site 545693013791 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 545693013792 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 545693013793 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 545693013794 [4Fe-4S] binding site [ion binding]; other site 545693013795 molybdopterin cofactor binding site; other site 545693013796 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 545693013797 molybdopterin cofactor binding site; other site 545693013798 Uncharacterized conserved protein [Function unknown]; Region: COG2427 545693013799 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 545693013800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693013801 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 545693013802 dimer interface [polypeptide binding]; other site 545693013803 conserved gate region; other site 545693013804 putative PBP binding loops; other site 545693013805 ABC-ATPase subunit interface; other site 545693013806 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 545693013807 SmpB-tmRNA interface; other site 545693013808 ribonuclease R; Region: RNase_R; TIGR02063 545693013809 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 545693013810 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 545693013811 RNB domain; Region: RNB; pfam00773 545693013812 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 545693013813 RNA binding site [nucleotide binding]; other site 545693013814 Esterase/lipase [General function prediction only]; Region: COG1647 545693013815 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693013816 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 545693013817 enolase; Provisional; Region: eno; PRK00077 545693013818 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 545693013819 dimer interface [polypeptide binding]; other site 545693013820 metal binding site [ion binding]; metal-binding site 545693013821 substrate binding pocket [chemical binding]; other site 545693013822 phosphoglyceromutase; Provisional; Region: PRK05434 545693013823 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 545693013824 substrate binding site [chemical binding]; other site 545693013825 dimer interface [polypeptide binding]; other site 545693013826 catalytic triad [active] 545693013827 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 545693013828 substrate binding site [chemical binding]; other site 545693013829 hinge regions; other site 545693013830 ADP binding site [chemical binding]; other site 545693013831 catalytic site [active] 545693013832 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 545693013833 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 545693013834 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 545693013835 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 545693013836 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 545693013837 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 545693013838 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 545693013839 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 545693013840 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 545693013841 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 545693013842 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 545693013843 oligomer interface [polypeptide binding]; other site 545693013844 active site residues [active] 545693013845 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 545693013846 dimerization domain swap beta strand [polypeptide binding]; other site 545693013847 regulatory protein interface [polypeptide binding]; other site 545693013848 active site 545693013849 regulatory phosphorylation site [posttranslational modification]; other site 545693013850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 545693013851 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 545693013852 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 545693013853 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 545693013854 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 545693013855 phosphate binding site [ion binding]; other site 545693013856 putative substrate binding pocket [chemical binding]; other site 545693013857 dimer interface [polypeptide binding]; other site 545693013858 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 545693013859 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 545693013860 putative active site [active] 545693013861 nucleotide binding site [chemical binding]; other site 545693013862 nudix motif; other site 545693013863 putative metal binding site [ion binding]; other site 545693013864 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 545693013865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693013866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693013867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693013868 binding surface 545693013869 TPR motif; other site 545693013870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693013871 binding surface 545693013872 Tetratricopeptide repeat; Region: TPR_16; pfam13432 545693013873 TPR motif; other site 545693013874 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 545693013875 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 545693013876 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 545693013877 metal binding site [ion binding]; metal-binding site 545693013878 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 545693013879 substrate binding site [chemical binding]; other site 545693013880 glutamase interaction surface [polypeptide binding]; other site 545693013881 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 545693013882 catalytic residues [active] 545693013883 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 545693013884 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 545693013885 putative active site [active] 545693013886 oxyanion strand; other site 545693013887 catalytic triad [active] 545693013888 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 545693013889 putative active site pocket [active] 545693013890 4-fold oligomerization interface [polypeptide binding]; other site 545693013891 metal binding residues [ion binding]; metal-binding site 545693013892 3-fold/trimer interface [polypeptide binding]; other site 545693013893 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 545693013894 histidinol dehydrogenase; Region: hisD; TIGR00069 545693013895 NAD binding site [chemical binding]; other site 545693013896 dimerization interface [polypeptide binding]; other site 545693013897 product binding site; other site 545693013898 substrate binding site [chemical binding]; other site 545693013899 zinc binding site [ion binding]; other site 545693013900 catalytic residues [active] 545693013901 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 545693013902 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 545693013903 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 545693013904 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 545693013905 dimer interface [polypeptide binding]; other site 545693013906 motif 1; other site 545693013907 active site 545693013908 motif 2; other site 545693013909 motif 3; other site 545693013910 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 545693013911 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 545693013912 trimer interface [polypeptide binding]; other site 545693013913 active site 545693013914 substrate binding site [chemical binding]; other site 545693013915 CoA binding site [chemical binding]; other site 545693013916 pyrophosphatase PpaX; Provisional; Region: PRK13288 545693013917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013918 active site 545693013919 motif I; other site 545693013920 motif II; other site 545693013921 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 545693013922 HPr kinase/phosphorylase; Provisional; Region: PRK05428 545693013923 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 545693013924 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 545693013925 Hpr binding site; other site 545693013926 active site 545693013927 homohexamer subunit interaction site [polypeptide binding]; other site 545693013928 Predicted membrane protein [Function unknown]; Region: COG1950 545693013929 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 545693013930 Uncharacterized conserved protein [Function unknown]; Region: COG3595 545693013931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 545693013932 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693013933 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 545693013934 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 545693013935 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 545693013936 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 545693013937 excinuclease ABC subunit B; Provisional; Region: PRK05298 545693013938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693013939 ATP binding site [chemical binding]; other site 545693013940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693013941 nucleotide binding region [chemical binding]; other site 545693013942 ATP-binding site [chemical binding]; other site 545693013943 Ultra-violet resistance protein B; Region: UvrB; pfam12344 545693013944 UvrB/uvrC motif; Region: UVR; pfam02151 545693013945 PAS domain S-box; Region: sensory_box; TIGR00229 545693013946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693013947 putative active site [active] 545693013948 heme pocket [chemical binding]; other site 545693013949 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693013950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693013951 Walker A motif; other site 545693013952 ATP binding site [chemical binding]; other site 545693013953 Walker B motif; other site 545693013954 arginine finger; other site 545693013955 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 545693013956 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 545693013957 Glutamate binding site [chemical binding]; other site 545693013958 homodimer interface [polypeptide binding]; other site 545693013959 NAD binding site [chemical binding]; other site 545693013960 catalytic residues [active] 545693013961 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 545693013962 Proline dehydrogenase; Region: Pro_dh; pfam01619 545693013963 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 545693013964 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 545693013965 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 545693013966 C-terminal peptidase (prc); Region: prc; TIGR00225 545693013967 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 545693013968 protein binding site [polypeptide binding]; other site 545693013969 Catalytic dyad [active] 545693013970 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 545693013971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 545693013972 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 545693013973 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693013974 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 545693013975 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 545693013976 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 545693013977 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 545693013978 Walker A/P-loop; other site 545693013979 ATP binding site [chemical binding]; other site 545693013980 Q-loop/lid; other site 545693013981 ABC transporter signature motif; other site 545693013982 Walker B; other site 545693013983 D-loop; other site 545693013984 H-loop/switch region; other site 545693013985 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 545693013986 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 545693013987 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 545693013988 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 545693013989 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 545693013990 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 545693013991 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 545693013992 putative active site [active] 545693013993 putative metal binding site [ion binding]; other site 545693013994 peptide chain release factor 2; Provisional; Region: PRK06746 545693013995 This domain is found in peptide chain release factors; Region: PCRF; smart00937 545693013996 RF-1 domain; Region: RF-1; pfam00472 545693013997 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 545693013998 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 545693013999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693014000 nucleotide binding region [chemical binding]; other site 545693014001 ATP-binding site [chemical binding]; other site 545693014002 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 545693014003 SEC-C motif; Region: SEC-C; pfam02810 545693014004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693014005 Coenzyme A binding pocket [chemical binding]; other site 545693014006 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 545693014007 30S subunit binding site; other site 545693014008 flagellar protein FliS; Validated; Region: fliS; PRK05685 545693014009 flagellar capping protein; Validated; Region: fliD; PRK07737 545693014010 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 545693014011 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 545693014012 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 545693014013 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 545693014014 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 545693014015 Na binding site [ion binding]; other site 545693014016 putative glycosylation site [posttranslational modification]; other site 545693014017 putative glycosylation site [posttranslational modification]; other site 545693014018 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 545693014019 tetramerization interface [polypeptide binding]; other site 545693014020 NAD(P) binding site [chemical binding]; other site 545693014021 catalytic residues [active] 545693014022 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 545693014023 active site 545693014024 NAD binding site [chemical binding]; other site 545693014025 metal binding site [ion binding]; metal-binding site 545693014026 MarR family; Region: MarR_2; cl17246 545693014027 carbon storage regulator; Provisional; Region: PRK01712 545693014028 flagellar assembly protein FliW; Provisional; Region: PRK13285 545693014029 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 545693014030 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 545693014031 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 545693014032 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 545693014033 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 545693014034 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 545693014035 FlgN protein; Region: FlgN; pfam05130 545693014036 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 545693014037 flagellar operon protein TIGR03826; Region: YvyF 545693014038 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 545693014039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693014040 active site 545693014041 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 545693014042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693014043 ATP binding site [chemical binding]; other site 545693014044 putative Mg++ binding site [ion binding]; other site 545693014045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693014046 nucleotide binding region [chemical binding]; other site 545693014047 ATP-binding site [chemical binding]; other site 545693014048 EDD domain protein, DegV family; Region: DegV; TIGR00762 545693014049 Protein of unknown function (DUF327); Region: DUF327; pfam03885 545693014050 Flagellar protein FliS; Region: FliS; cl00654 545693014051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693014052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014053 active site 545693014054 phosphorylation site [posttranslational modification] 545693014055 intermolecular recognition site; other site 545693014056 dimerization interface [polypeptide binding]; other site 545693014057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693014058 DNA binding residues [nucleotide binding] 545693014059 dimerization interface [polypeptide binding]; other site 545693014060 Sensor protein DegS; Region: DegS; pfam05384 545693014061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 545693014062 Histidine kinase; Region: HisKA_3; pfam07730 545693014063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014064 ATP binding site [chemical binding]; other site 545693014065 Mg2+ binding site [ion binding]; other site 545693014066 G-X-G motif; other site 545693014067 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 545693014068 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 545693014069 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 545693014070 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693014071 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 545693014072 Mg++ binding site [ion binding]; other site 545693014073 putative catalytic motif [active] 545693014074 substrate binding site [chemical binding]; other site 545693014075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 545693014076 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 545693014077 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 545693014078 Orbivirus outer capsid protein VP5; Region: Orbi_VP5; pfam00901 545693014079 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 545693014080 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 545693014081 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 545693014082 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 545693014083 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 545693014084 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693014085 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 545693014086 active site 545693014087 tetramer interface; other site 545693014088 Uncharacterized conserved protein [Function unknown]; Region: COG4715 545693014089 SNF2 Helicase protein; Region: DUF3670; pfam12419 545693014090 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 545693014091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693014092 ATP binding site [chemical binding]; other site 545693014093 putative Mg++ binding site [ion binding]; other site 545693014094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693014095 nucleotide binding region [chemical binding]; other site 545693014096 ATP-binding site [chemical binding]; other site 545693014097 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 545693014098 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693014099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693014100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 545693014101 NlpC/P60 family; Region: NLPC_P60; pfam00877 545693014102 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 545693014103 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 545693014104 dimer interface [polypeptide binding]; other site 545693014105 ssDNA binding site [nucleotide binding]; other site 545693014106 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693014107 YwpF-like protein; Region: YwpF; pfam14183 545693014108 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693014109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693014110 non-specific DNA binding site [nucleotide binding]; other site 545693014111 salt bridge; other site 545693014112 sequence-specific DNA binding site [nucleotide binding]; other site 545693014113 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 545693014114 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 545693014115 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 545693014116 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 545693014117 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 545693014118 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 545693014119 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 545693014120 rod shape-determining protein Mbl; Provisional; Region: PRK13928 545693014121 MreB and similar proteins; Region: MreB_like; cd10225 545693014122 nucleotide binding site [chemical binding]; other site 545693014123 Mg binding site [ion binding]; other site 545693014124 putative protofilament interaction site [polypeptide binding]; other site 545693014125 RodZ interaction site [polypeptide binding]; other site 545693014126 Stage III sporulation protein D; Region: SpoIIID; cl17560 545693014127 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 545693014128 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693014129 stage II sporulation protein D; Region: spore_II_D; TIGR02870 545693014130 Stage II sporulation protein; Region: SpoIID; pfam08486 545693014131 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 545693014132 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 545693014133 hinge; other site 545693014134 active site 545693014135 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 545693014136 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 545693014137 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 545693014138 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 545693014139 gamma subunit interface [polypeptide binding]; other site 545693014140 epsilon subunit interface [polypeptide binding]; other site 545693014141 LBP interface [polypeptide binding]; other site 545693014142 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 545693014143 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 545693014144 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 545693014145 alpha subunit interaction interface [polypeptide binding]; other site 545693014146 Walker A motif; other site 545693014147 ATP binding site [chemical binding]; other site 545693014148 Walker B motif; other site 545693014149 inhibitor binding site; inhibition site 545693014150 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 545693014151 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 545693014152 core domain interface [polypeptide binding]; other site 545693014153 delta subunit interface [polypeptide binding]; other site 545693014154 epsilon subunit interface [polypeptide binding]; other site 545693014155 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 545693014156 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 545693014157 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 545693014158 beta subunit interaction interface [polypeptide binding]; other site 545693014159 Walker A motif; other site 545693014160 ATP binding site [chemical binding]; other site 545693014161 Walker B motif; other site 545693014162 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 545693014163 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 545693014164 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 545693014165 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 545693014166 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 545693014167 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 545693014168 ATP synthase I chain; Region: ATP_synt_I; pfam03899 545693014169 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 545693014170 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 545693014171 Subtilase family; Region: Peptidase_S8; pfam00082 545693014172 catalytic triad [active] 545693014173 putative active site [active] 545693014174 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 545693014175 PA/protease or protease-like domain interface [polypeptide binding]; other site 545693014176 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 545693014177 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 545693014178 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 545693014179 active site 545693014180 homodimer interface [polypeptide binding]; other site 545693014181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693014182 active site 545693014183 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 545693014184 dimer interface [polypeptide binding]; other site 545693014185 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 545693014186 active site 545693014187 glycine-pyridoxal phosphate binding site [chemical binding]; other site 545693014188 folate binding site [chemical binding]; other site 545693014189 hypothetical protein; Provisional; Region: PRK13690 545693014190 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 545693014191 Low molecular weight phosphatase family; Region: LMWPc; cd00115 545693014192 active site 545693014193 Predicted membrane protein [Function unknown]; Region: COG1971 545693014194 Domain of unknown function DUF; Region: DUF204; pfam02659 545693014195 Domain of unknown function DUF; Region: DUF204; pfam02659 545693014196 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 545693014197 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 545693014198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693014199 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 545693014200 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 545693014201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014202 S-adenosylmethionine binding site [chemical binding]; other site 545693014203 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 545693014204 peptide chain release factor 1; Validated; Region: prfA; PRK00591 545693014205 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693014206 This domain is found in peptide chain release factors; Region: PCRF; smart00937 545693014207 RF-1 domain; Region: RF-1; pfam00472 545693014208 thymidine kinase; Provisional; Region: PRK04296 545693014209 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 545693014210 transcription termination factor Rho; Provisional; Region: rho; PRK09376 545693014211 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 545693014212 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 545693014213 RNA binding site [nucleotide binding]; other site 545693014214 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 545693014215 multimer interface [polypeptide binding]; other site 545693014216 Walker A motif; other site 545693014217 ATP binding site [chemical binding]; other site 545693014218 Walker B motif; other site 545693014219 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 545693014220 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 545693014221 hinge; other site 545693014222 active site 545693014223 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693014224 active site 545693014225 intersubunit interactions; other site 545693014226 catalytic residue [active] 545693014227 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 545693014228 intersubunit interface [polypeptide binding]; other site 545693014229 active site 545693014230 zinc binding site [ion binding]; other site 545693014231 Na+ binding site [ion binding]; other site 545693014232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014233 active site 545693014234 phosphorylation site [posttranslational modification] 545693014235 intermolecular recognition site; other site 545693014236 dimerization interface [polypeptide binding]; other site 545693014237 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 545693014238 CTP synthetase; Validated; Region: pyrG; PRK05380 545693014239 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 545693014240 Catalytic site [active] 545693014241 active site 545693014242 UTP binding site [chemical binding]; other site 545693014243 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 545693014244 active site 545693014245 putative oxyanion hole; other site 545693014246 catalytic triad [active] 545693014247 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 545693014248 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 545693014249 B12 binding site [chemical binding]; other site 545693014250 cobalt ligand [ion binding]; other site 545693014251 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 545693014252 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 545693014253 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 545693014254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693014255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693014256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693014257 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 545693014258 FAD binding site [chemical binding]; other site 545693014259 homotetramer interface [polypeptide binding]; other site 545693014260 substrate binding pocket [chemical binding]; other site 545693014261 catalytic base [active] 545693014262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693014263 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 545693014264 FAD binding site [chemical binding]; other site 545693014265 homotetramer interface [polypeptide binding]; other site 545693014266 substrate binding pocket [chemical binding]; other site 545693014267 catalytic base [active] 545693014268 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 545693014269 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 545693014270 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693014271 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 545693014272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693014273 dimer interface [polypeptide binding]; other site 545693014274 active site 545693014275 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 545693014276 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693014277 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 545693014278 Cysteine-rich domain; Region: CCG; pfam02754 545693014279 Cysteine-rich domain; Region: CCG; pfam02754 545693014280 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693014281 PLD-like domain; Region: PLDc_2; pfam13091 545693014282 putative active site [active] 545693014283 catalytic site [active] 545693014284 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693014285 PLD-like domain; Region: PLDc_2; pfam13091 545693014286 putative active site [active] 545693014287 catalytic site [active] 545693014288 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 545693014289 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 545693014290 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 545693014291 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 545693014292 active site 545693014293 HIGH motif; other site 545693014294 KMSK motif region; other site 545693014295 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 545693014296 tRNA binding surface [nucleotide binding]; other site 545693014297 anticodon binding site; other site 545693014298 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 545693014299 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 545693014300 putative active site [active] 545693014301 Mn binding site [ion binding]; other site 545693014302 spermidine synthase; Provisional; Region: PRK00811 545693014303 Transglycosylase; Region: Transgly; pfam00912 545693014304 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693014305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 545693014306 YwhD family; Region: YwhD; pfam08741 545693014307 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 545693014308 Peptidase family M50; Region: Peptidase_M50; pfam02163 545693014309 active site 545693014310 putative substrate binding region [chemical binding]; other site 545693014311 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 545693014312 active site 1 [active] 545693014313 dimer interface [polypeptide binding]; other site 545693014314 hexamer interface [polypeptide binding]; other site 545693014315 active site 2 [active] 545693014316 Uncharacterized conserved protein [Function unknown]; Region: COG3465 545693014317 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 545693014318 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693014319 Zn2+ binding site [ion binding]; other site 545693014320 Mg2+ binding site [ion binding]; other site 545693014321 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 545693014322 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 545693014323 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 545693014324 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 545693014325 putative heme peroxidase; Provisional; Region: PRK12276 545693014326 cell wall hydrolase CwlJ, frameshift 545693014327 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 545693014328 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 545693014329 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 545693014330 ligand binding site [chemical binding]; other site 545693014331 active site 545693014332 UGI interface [polypeptide binding]; other site 545693014333 catalytic site [active] 545693014334 Staygreen protein; Region: Staygreen; pfam12638 545693014335 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693014336 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693014337 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693014338 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 545693014339 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 545693014340 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 545693014341 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 545693014342 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 545693014343 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 545693014344 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 545693014345 hexamer interface [polypeptide binding]; other site 545693014346 ligand binding site [chemical binding]; other site 545693014347 putative active site [active] 545693014348 NAD(P) binding site [chemical binding]; other site 545693014349 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 545693014350 dimer interface [polypeptide binding]; other site 545693014351 substrate binding site [chemical binding]; other site 545693014352 ATP binding site [chemical binding]; other site 545693014353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693014354 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693014355 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693014356 active site 545693014357 motif I; other site 545693014358 motif II; other site 545693014359 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693014360 beta-phosphoglucomutase; Region: bPGM; TIGR01990 545693014361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693014362 motif II; other site 545693014363 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 545693014364 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 545693014365 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693014366 active site turn [active] 545693014367 phosphorylation site [posttranslational modification] 545693014368 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 545693014369 putative catalytic site [active] 545693014370 putative metal binding site [ion binding]; other site 545693014371 putative phosphate binding site [ion binding]; other site 545693014372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693014373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693014374 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 545693014375 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 545693014376 Ligand binding site; other site 545693014377 Putative Catalytic site; other site 545693014378 DXD motif; other site 545693014379 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 545693014380 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693014381 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 545693014382 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 545693014383 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 545693014384 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 545693014385 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 545693014386 TrkA-N domain; Region: TrkA_N; pfam02254 545693014387 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 545693014388 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693014389 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 545693014390 Walker A/P-loop; other site 545693014391 ATP binding site [chemical binding]; other site 545693014392 Q-loop/lid; other site 545693014393 ABC transporter signature motif; other site 545693014394 Walker B; other site 545693014395 D-loop; other site 545693014396 H-loop/switch region; other site 545693014397 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 545693014398 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 545693014399 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 545693014400 Walker A/P-loop; other site 545693014401 ATP binding site [chemical binding]; other site 545693014402 Q-loop/lid; other site 545693014403 ABC transporter signature motif; other site 545693014404 Walker B; other site 545693014405 D-loop; other site 545693014406 H-loop/switch region; other site 545693014407 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 545693014408 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 545693014409 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 545693014410 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 545693014411 Uncharacterized conserved protein [Function unknown]; Region: COG2966 545693014412 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 545693014413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693014414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693014415 DNA binding site [nucleotide binding] 545693014416 domain linker motif; other site 545693014417 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693014418 dimerization interface [polypeptide binding]; other site 545693014419 ligand binding site [chemical binding]; other site 545693014420 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 545693014421 Putative esterase; Region: Esterase; pfam00756 545693014422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 545693014423 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 545693014424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014425 putative substrate translocation pore; other site 545693014426 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 545693014427 putative catalytic cysteine [active] 545693014428 gamma-glutamyl kinase; Provisional; Region: PRK05429 545693014429 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 545693014430 nucleotide binding site [chemical binding]; other site 545693014431 homotetrameric interface [polypeptide binding]; other site 545693014432 putative phosphate binding site [ion binding]; other site 545693014433 putative allosteric binding site; other site 545693014434 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 545693014435 Carbon starvation protein CstA; Region: CstA; pfam02554 545693014436 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 545693014437 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 545693014438 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 545693014439 tetramer interface [polypeptide binding]; other site 545693014440 heme binding pocket [chemical binding]; other site 545693014441 NADPH binding site [chemical binding]; other site 545693014442 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 545693014443 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 545693014444 active site 545693014445 Na/Ca binding site [ion binding]; other site 545693014446 catalytic site [active] 545693014447 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 545693014448 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 545693014449 anion transporter; Region: dass; TIGR00785 545693014450 transmembrane helices; other site 545693014451 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 545693014452 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 545693014453 putative RNA binding site [nucleotide binding]; other site 545693014454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014455 S-adenosylmethionine binding site [chemical binding]; other site 545693014456 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014457 Predicted membrane protein [Function unknown]; Region: COG3212 545693014458 Predicted membrane protein [Function unknown]; Region: COG3212 545693014459 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693014461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014462 active site 545693014463 phosphorylation site [posttranslational modification] 545693014464 intermolecular recognition site; other site 545693014465 dimerization interface [polypeptide binding]; other site 545693014466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693014467 DNA binding site [nucleotide binding] 545693014468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693014469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693014470 dimerization interface [polypeptide binding]; other site 545693014471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693014472 dimer interface [polypeptide binding]; other site 545693014473 phosphorylation site [posttranslational modification] 545693014474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014475 ATP binding site [chemical binding]; other site 545693014476 Mg2+ binding site [ion binding]; other site 545693014477 G-X-G motif; other site 545693014478 Predicted membrane protein [Function unknown]; Region: COG3212 545693014479 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014480 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014481 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014482 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014483 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 545693014484 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 545693014485 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 545693014486 FMN binding site [chemical binding]; other site 545693014487 active site 545693014488 catalytic residues [active] 545693014489 substrate binding site [chemical binding]; other site 545693014490 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 545693014491 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 545693014492 Domain of unknown function (DUF3357); Region: DUF3357; pfam11837 545693014493 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 545693014494 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 545693014495 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 545693014496 protein binding site [polypeptide binding]; other site 545693014497 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 545693014498 YycH protein; Region: YycI; cl02015 545693014499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 545693014500 YycH protein; Region: YycH; pfam07435 545693014501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 545693014502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693014503 dimerization interface [polypeptide binding]; other site 545693014504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693014505 putative active site [active] 545693014506 heme pocket [chemical binding]; other site 545693014507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693014508 dimer interface [polypeptide binding]; other site 545693014509 phosphorylation site [posttranslational modification] 545693014510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014511 ATP binding site [chemical binding]; other site 545693014512 Mg2+ binding site [ion binding]; other site 545693014513 G-X-G motif; other site 545693014514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693014515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014516 active site 545693014517 phosphorylation site [posttranslational modification] 545693014518 intermolecular recognition site; other site 545693014519 dimerization interface [polypeptide binding]; other site 545693014520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693014521 DNA binding site [nucleotide binding] 545693014522 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 545693014523 GDP-binding site [chemical binding]; other site 545693014524 ACT binding site; other site 545693014525 IMP binding site; other site 545693014526 replicative DNA helicase; Provisional; Region: PRK05748 545693014527 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 545693014528 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 545693014529 Walker A motif; other site 545693014530 ATP binding site [chemical binding]; other site 545693014531 Walker B motif; other site 545693014532 DNA binding loops [nucleotide binding] 545693014533 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 545693014534 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 545693014535 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 545693014536 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 545693014537 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 545693014538 DHH family; Region: DHH; pfam01368 545693014539 DHHA1 domain; Region: DHHA1; pfam02272 545693014540 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 545693014541 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 545693014542 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 545693014543 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 545693014544 dimer interface [polypeptide binding]; other site 545693014545 ssDNA binding site [nucleotide binding]; other site 545693014546 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693014547 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 545693014548 GTP-binding protein YchF; Reviewed; Region: PRK09601 545693014549 YchF GTPase; Region: YchF; cd01900 545693014550 G1 box; other site 545693014551 GTP/Mg2+ binding site [chemical binding]; other site 545693014552 Switch I region; other site 545693014553 G2 box; other site 545693014554 Switch II region; other site 545693014555 G3 box; other site 545693014556 G4 box; other site 545693014557 G5 box; other site 545693014558 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 545693014559 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 545693014560 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 545693014561 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693014562 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 545693014563 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 545693014564 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 545693014565 ParB-like nuclease domain; Region: ParB; smart00470 545693014566 KorB domain; Region: KorB; pfam08535 545693014567 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 545693014568 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 545693014569 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 545693014570 P-loop; other site 545693014571 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 545693014572 Magnesium ion binding site [ion binding]; other site 545693014573 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 545693014574 ParB-like nuclease domain; Region: ParBc; pfam02195 545693014575 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 545693014576 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693014577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014578 S-adenosylmethionine binding site [chemical binding]; other site 545693014579 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 545693014580 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 545693014581 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 545693014582 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 545693014583 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 545693014584 trmE is a tRNA modification GTPase; Region: trmE; cd04164 545693014585 G1 box; other site 545693014586 GTP/Mg2+ binding site [chemical binding]; other site 545693014587 Switch I region; other site 545693014588 G2 box; other site 545693014589 Switch II region; other site 545693014590 G3 box; other site 545693014591 G4 box; other site 545693014592 G5 box; other site 545693014593 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 545693014594 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 545693014595 Jag N-terminus; Region: Jag_N; pfam14804 545693014596 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 545693014597 G-X-X-G motif; other site 545693014598 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 545693014599 RxxxH motif; other site 545693014600 OxaA-like protein precursor; Validated; Region: PRK02944 545693014601 ribonuclease P; Reviewed; Region: rnpA; PRK00499 545693014602 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 545693014603 RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127 545693014604 Beta-catenin-interacting protein ICAT; Region: ICAT; pfam06384 545693014605 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 545693014606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693014607 putative DNA binding site [nucleotide binding]; other site 545693014608 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693014609 DNA binding residues [nucleotide binding] 545693014610 putative Zn2+ binding site [ion binding]; other site 545693014611 dimerization interface [polypeptide binding]; other site 545693014612 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 545693014613 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 545693014614 Replication-relaxation; Region: Replic_Relax; pfam13814 545693014615 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693014616 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 545693014617 YolD-like protein; Region: YolD; pfam08863 545693014618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693014619 putative DNA binding site [nucleotide binding]; other site 545693014620 putative Zn2+ binding site [ion binding]; other site 545693014621 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693014622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693014623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 545693014624 Walker A/P-loop; other site 545693014625 ATP binding site [chemical binding]; other site 545693014626 Q-loop/lid; other site 545693014627 ABC transporter signature motif; other site 545693014628 Walker B; other site 545693014629 D-loop; other site 545693014630 H-loop/switch region; other site 545693014631 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693014632 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 545693014633 active site 545693014634 8-oxo-dGMP binding site [chemical binding]; other site 545693014635 nudix motif; other site 545693014636 metal binding site [ion binding]; metal-binding site 545693014637 HNH endonuclease; Region: HNH_2; pfam13391 545693014638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693014639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693014640 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693014641 putative dimerization interface [polypeptide binding]; other site 545693014642 glutamate dehydrogenase; Provisional; Region: PRK09414 545693014643 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 545693014644 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 545693014645 NAD(P) binding site [chemical binding]; other site 545693014646 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 545693014647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014648 putative substrate translocation pore; other site 545693014649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 545693014650 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 545693014651 Predicted membrane protein [Function unknown]; Region: COG2323 545693014652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693014653 DNA-binding site [nucleotide binding]; DNA binding site 545693014654 RNA-binding motif; other site 545693014655 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693014656 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 545693014657 DNA binding residues [nucleotide binding] 545693014658 dimer interface [polypeptide binding]; other site 545693014659 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 545693014660 Putative lysophospholipase; Region: Hydrolase_4; cl19140 545693014661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693014662 Anti-repressor SinI; Region: SinI; pfam08671 545693014663 YheO-like PAS domain; Region: PAS_6; pfam08348 545693014664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 545693014665 HTH domain; Region: HTH_22; pfam13309 545693014666 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 545693014667 homotrimer interaction site [polypeptide binding]; other site 545693014668 putative active site [active] 545693014669 threonine synthase; Validated; Region: PRK06450 545693014670 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 545693014671 homodimer interface [polypeptide binding]; other site 545693014672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693014673 catalytic residue [active] 545693014674 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693014675 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 545693014676 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 545693014677 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693014678 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693014679 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014680 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693014681 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693014682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693014684 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693014685 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 545693014686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014687 putative substrate translocation pore; other site 545693014688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 545693014690 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693014691 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693014692 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693014693 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 545693014694 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 545693014695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693014696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693014697 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 545693014698 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 545693014699 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693014700 DNA-binding site [nucleotide binding]; DNA binding site 545693014701 RNA-binding motif; other site 545693014702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014703 S-adenosylmethionine binding site [chemical binding]; other site 545693014704 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693014705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014706 S-adenosylmethionine binding site [chemical binding]; other site 545693014707 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 545693014708 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 545693014709 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 545693014710 putative active site [active] 545693014711 putative NTP binding site [chemical binding]; other site 545693014712 putative nucleic acid binding site [nucleotide binding]; other site 545693014713 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 545693014714 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 545693014715 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693014716 putative active site [active] 545693014717 catalytic site [active] 545693014718 putative metal binding site [ion binding]; other site 545693014719 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 545693014720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014721 putative substrate translocation pore; other site 545693014722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014723 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693014724 putative substrate translocation pore; other site 545693014725 Transposase; Region: DEDD_Tnp_IS110; pfam01548 545693014726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693014727 dimerization interface [polypeptide binding]; other site 545693014728 Transcriptional regulators [Transcription]; Region: MarR; COG1846 545693014729 putative Zn2+ binding site [ion binding]; other site 545693014730 putative DNA binding site [nucleotide binding]; other site 545693014731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693014732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693014733 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 545693014734 putative active site [active] 545693014735 putative FMN binding site [chemical binding]; other site 545693014736 putative substrate binding site [chemical binding]; other site 545693014737 putative catalytic residue [active] 545693014738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693014739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 545693014740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693014741 dimerization interface [polypeptide binding]; other site 545693014742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014743 S-adenosylmethionine binding site [chemical binding]; other site 545693014744 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693014745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014746 S-adenosylmethionine binding site [chemical binding]; other site 545693014747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 545693014748 putative acyl-acceptor binding pocket; other site 545693014749 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 545693014750 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 545693014751 dimer interface [polypeptide binding]; other site 545693014752 active site 545693014753 CoA binding pocket [chemical binding]; other site 545693014754 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 545693014755 YtxH-like protein; Region: YtxH; cl02079 545693014756 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693014757 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 545693014758 Spore germination protein; Region: Spore_permease; pfam03845 545693014759 Spore germination protein; Region: Spore_permease; pfam03845 545693014760 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693014761 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 545693014762 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693014763 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693014764 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693014765 BCCT family transporter; Region: BCCT; pfam02028 545693014766 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693014767 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693014768 Ligand Binding Site [chemical binding]; other site 545693014769 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 545693014770 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 545693014771 Sulfate transporter family; Region: Sulfate_transp; pfam00916 545693014772 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 545693014773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693014774 non-specific DNA binding site [nucleotide binding]; other site 545693014775 salt bridge; other site 545693014776 sequence-specific DNA binding site [nucleotide binding]; other site 545693014777 multiple promoter invertase; Provisional; Region: mpi; PRK13413 545693014778 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 545693014779 catalytic residues [active] 545693014780 catalytic nucleophile [active] 545693014781 Presynaptic Site I dimer interface [polypeptide binding]; other site 545693014782 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 545693014783 Synaptic Flat tetramer interface [polypeptide binding]; other site 545693014784 Synaptic Site I dimer interface [polypeptide binding]; other site 545693014785 DNA binding site [nucleotide binding] 545693014786 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 545693014787 DNA-binding interface [nucleotide binding]; DNA binding site 545693014788 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 545693014789 CrcB-like protein; Region: CRCB; cl09114 545693014790 CrcB-like protein; Region: CRCB; cl09114 545693014791 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693014792 putative DNA binding site [nucleotide binding]; other site 545693014793 dimerization interface [polypeptide binding]; other site 545693014794 putative Zn2+ binding site [ion binding]; other site 545693014795 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 545693014796 nudix motif; other site 545693014797 GrpB protein; Region: GrpB; pfam04229 545693014798 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693014799 catalytic core [active] 545693014800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693014801 classical (c) SDRs; Region: SDR_c; cd05233 545693014802 NAD(P) binding site [chemical binding]; other site 545693014803 active site 545693014804 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 545693014805 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693014806 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 545693014807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693014808 motif II; other site 545693014809 stage V sporulation protein B; Region: spore_V_B; TIGR02900 545693014810 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 545693014811 Coat F domain; Region: Coat_F; pfam07875 545693014812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 545693014813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693014814 salt bridge; other site 545693014815 non-specific DNA binding site [nucleotide binding]; other site 545693014816 sequence-specific DNA binding site [nucleotide binding]; other site 545693014817 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 545693014818 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693014819 dimer interface [polypeptide binding]; other site 545693014820 active site 545693014821 DNA polymerase IV; Reviewed; Region: PRK03103 545693014822 Y-family of DNA polymerases; Region: PolY; cl12025 545693014823 active site 545693014824 DNA binding site [nucleotide binding] 545693014825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693014826 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 545693014827 active site 545693014828 catalytic tetrad [active] 545693014829 4-carboxymuconolactone decarboxylase, frameshift 545693014830 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 545693014831 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 545693014832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693014833 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 545693014834 DNA-binding site [nucleotide binding]; DNA binding site 545693014835 RNA-binding motif; other site 545693014836 The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of...; Region: ML; cl00274 545693014837 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693014838 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 545693014839 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693014840 nucleotide binding site [chemical binding]; other site 545693014841 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 545693014842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 545693014843 Transposase; Region: DEDD_Tnp_IS110; pfam01548 545693014844 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 545693014845 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693014846 catalytic triad [active] 545693014847 conserved cis-peptide bond; other site 545693014848 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 545693014849 Subtilase family; Region: Peptidase_S8; pfam00082 545693014850 active site 545693014851 catalytic triad [active] 545693014852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693014853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693014854 dimerization interface [polypeptide binding]; other site 545693014855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693014856 dimer interface [polypeptide binding]; other site 545693014857 phosphorylation site [posttranslational modification] 545693014858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014859 ATP binding site [chemical binding]; other site 545693014860 Mg2+ binding site [ion binding]; other site 545693014861 G-X-G motif; other site 545693014862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693014863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014864 active site 545693014865 phosphorylation site [posttranslational modification] 545693014866 intermolecular recognition site; other site 545693014867 dimerization interface [polypeptide binding]; other site 545693014868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693014869 DNA binding site [nucleotide binding] 545693014870 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 545693014871 FtsX-like permease family; Region: FtsX; pfam02687 545693014872 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693014873 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 545693014874 Walker A/P-loop; other site 545693014875 ATP binding site [chemical binding]; other site 545693014876 Q-loop/lid; other site 545693014877 ABC transporter signature motif; other site 545693014878 Walker B; other site 545693014879 D-loop; other site 545693014880 H-loop/switch region; other site 545693014881 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 545693014882 Acyltransferase family; Region: Acyl_transf_3; cl19154 545693014883 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 545693014884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693014885 Walker A/P-loop; other site 545693014886 ATP binding site [chemical binding]; other site 545693014887 Q-loop/lid; other site 545693014888 ABC transporter signature motif; other site 545693014889 Walker B; other site 545693014890 D-loop; other site 545693014891 H-loop/switch region; other site 545693014892 Flavoprotein; Region: Flavoprotein; pfam02441 545693014893 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 545693014894 active site 545693014895 zinc binding site [ion binding]; other site 545693014896 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693014897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 545693014898 Walker A/P-loop; other site 545693014899 ATP binding site [chemical binding]; other site 545693014900 Q-loop/lid; other site 545693014901 ABC transporter signature motif; other site 545693014902 Walker B; other site 545693014903 D-loop; other site 545693014904 H-loop/switch region; other site 545693014905 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 545693014906 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 545693014907 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 545693014908 Gallidermin; Region: Gallidermin; cl03420 545693014909 Gallidermin; Region: Gallidermin; cl03420 545693014910 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cd00385 545693014911 substrate binding pocket [chemical binding]; other site 545693014912 substrate-Mg2+ binding site; other site 545693014913 aspartate-rich region 1; other site 545693014914 aspartate-rich region 2; other site 545693014915 Histidine kinase; Region: HisKA_3; pfam07730 545693014916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014917 ATP binding site [chemical binding]; other site 545693014918 Mg2+ binding site [ion binding]; other site 545693014919 G-X-G motif; other site 545693014920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693014921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014922 active site 545693014923 phosphorylation site [posttranslational modification] 545693014924 intermolecular recognition site; other site 545693014925 dimerization interface [polypeptide binding]; other site 545693014926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693014927 DNA binding residues [nucleotide binding] 545693014928 dimerization interface [polypeptide binding]; other site 545693014929 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 545693014930 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 545693014931 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 545693014932 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 545693014933 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693014934 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 545693014935 active site 545693014936 metal-binding site 545693014937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693014938 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 545693014939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693014940 homodimer interface [polypeptide binding]; other site 545693014941 catalytic residue [active] 545693014942 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 545693014943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 545693014944 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 545693014945 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 545693014946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693014947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014948 putative substrate translocation pore; other site 545693014949 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693014950 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 545693014951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693014952 motif II; other site 545693014953 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 545693014954 YtkA-like; Region: YtkA; pfam13115 545693014955 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 545693014956 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 545693014957 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 545693014958 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 545693014959 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693014960 Subtilase family; Region: Peptidase_S8; pfam00082 545693014961 active site 545693014962 catalytic residues [active] 545693014963 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206 545693014964 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 545693014965 Beta-catenin-interacting protein ICAT; Region: ICAT; pfam06384 545693014966 Protein of unknown function (DUF1421); Region: DUF1421; pfam07223 545693014967 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693014968 DNA binding residues [nucleotide binding] 545693014969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693014970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693014971 salt bridge; other site 545693014972 non-specific DNA binding site [nucleotide binding]; other site 545693014973 sequence-specific DNA binding site [nucleotide binding]; other site 545693014974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 545693014975 Replication-relaxation; Region: Replic_Relax; pfam13814 545693014976 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 545693014977 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 545693014978 hypothetical protein; Provisional; Region: PRK14082 545693014979 YvrJ protein family; Region: YvrJ; pfam12841 545693014980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 545693014981 DNA binding residues [nucleotide binding] 545693014982 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 545693014983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 545693014984 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693014985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014986 NAD(P) binding site [chemical binding]; other site 545693014987 active site 545693014988 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693014989 active site 545693014990 metal binding site [ion binding]; metal-binding site 545693014991 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 545693014993 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 545693014994 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 545693014995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693014996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693014997 DNA binding residues [nucleotide binding] 545693014998 Putative zinc-finger; Region: zf-HC2; pfam13490 545693014999 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 545693015000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693015001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693015002 non-specific DNA binding site [nucleotide binding]; other site 545693015003 salt bridge; other site 545693015004 sequence-specific DNA binding site [nucleotide binding]; other site 545693015005 General stress protein [General function prediction only]; Region: GsiB; COG3729 545693015006 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693015007 YolD-like protein; Region: YolD; pfam08863 545693015008 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693015009 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693015010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693015011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693015012 putative substrate translocation pore; other site 545693015013 Repeat of unknown function (DUF1103); Region: DUF1103; pfam06513 545693015014 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 545693015015 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693015016 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 545693015017 dimer interface [polypeptide binding]; other site 545693015018 active site 545693015019 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 545693015020 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 545693015021 active site 545693015022 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 545693015023 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 545693015024 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 545693015025 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 545693015026 Phosphopantetheine attachment site; Region: PP-binding; cl09936 545693015027 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693015028 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693015029 NAD(P) binding site [chemical binding]; other site 545693015030 homotetramer interface [polypeptide binding]; other site 545693015031 homodimer interface [polypeptide binding]; other site 545693015032 active site 545693015033 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 545693015034 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 545693015035 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693015036 active site 545693015037 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693015038 classical (c) SDRs; Region: SDR_c; cd05233 545693015039 NAD(P) binding site [chemical binding]; other site 545693015040 active site 545693015041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693015042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 545693015043 Coenzyme A binding pocket [chemical binding]; other site 545693015044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693015045 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693015046 putative substrate translocation pore; other site 545693015047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693015048 putative DNA binding site [nucleotide binding]; other site 545693015049 dimerization interface [polypeptide binding]; other site 545693015050 putative Zn2+ binding site [ion binding]; other site 545693015051 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 545693015052 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 545693015053 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 545693015054 dimer interface [polypeptide binding]; other site 545693015055 putative tRNA-binding site [nucleotide binding]; other site 545693015056 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 545693015057 EamA-like transporter family; Region: EamA; pfam00892 545693015058 EamA-like transporter family; Region: EamA; pfam00892 545693015059 Heat induced stress protein YflT; Region: YflT; pfam11181 545693015060 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693015061 Subtilase family; Region: Peptidase_S8; pfam00082 545693015062 active site 545693015063 catalytic residues [active] 545693015064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693015065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693015066 non-specific DNA binding site [nucleotide binding]; other site 545693015067 salt bridge; other site 545693015068 sequence-specific DNA binding site [nucleotide binding]; other site 545693015069 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 545693015070 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693015071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693015072 active site 545693015073 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 545693015074 putative metal binding site; other site 545693015075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693015076 binding surface 545693015077 TPR motif; other site 545693015078 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 545693015079 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 545693015080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 545693015081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693015082 S-adenosylmethionine binding site [chemical binding]; other site 545693015083 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 545693015084 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 545693015085 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 545693015086 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693015087 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693015088 DNA binding residues [nucleotide binding] 545693015089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 545693015090 nucleotide binding site [chemical binding]; other site 545693015091 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693015092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693015093 putative substrate translocation pore; other site 545693015094 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 545693015095 RNA polymerase factor sigma-70; Validated; Region: PRK08295 545693015096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693015097 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 545693015098 DNA binding residues [nucleotide binding] 545693015099 Initiator Replication protein; Region: Rep_3; pfam01051 545693015100 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 545693015101 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 545693015102 active site 545693015103 catalytic residues [active] 545693015104 DNA binding site [nucleotide binding] 545693015105 Int/Topo IB signature motif; other site 545693015106 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693015107 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693015108 DNA binding residues [nucleotide binding] 545693015109 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 545693015110 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693015111 catalytic residues [active] 545693015112 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693015113 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693015114 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 545693015115 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 545693015116 active site 545693015117 homodimer interface [polypeptide binding]; other site 545693015118 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 545693015119 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 545693015120 NAD(P) binding site [chemical binding]; other site 545693015121 homodimer interface [polypeptide binding]; other site 545693015122 substrate binding site [chemical binding]; other site 545693015123 active site 545693015124 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 545693015125 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 545693015126 NADP binding site [chemical binding]; other site 545693015127 active site 545693015128 putative substrate binding site [chemical binding]; other site 545693015129 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693015130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693015131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693015132 NAD(P) binding site [chemical binding]; other site 545693015133 active site 545693015134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693015135 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693015136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693015137 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 545693015138 NAD(P) binding site [chemical binding]; other site 545693015139 active site 545693015140 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 545693015141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693015142 active site 545693015143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693015144 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693015145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693015146 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693015147 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693015148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693015149 active site 545693015150 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 545693015151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693015152 active site 545693015153 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693015154 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693015155 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693015156 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693015157 putative transposase, point mutation 545693015158 Uncharacterized conserved protein [Function unknown]; Region: COG3391 545693015159 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015160 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015161 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015162 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015163 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 545693015164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693015165 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693015166 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 545693015167 ATP-grasp domain; Region: ATP-grasp_4; cl17255 545693015168 Ecdysteroid kinase; Region: EcKinase; cl17738 545693015169 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 545693015170 active site 545693015171 substrate binding site [chemical binding]; other site 545693015172 ATP binding site [chemical binding]; other site 545693015173 putative transposase OrfB; Reviewed; Region: PHA02517 545693015174 HTH-like domain; Region: HTH_21; pfam13276 545693015175 Integrase core domain; Region: rve; pfam00665 545693015176 Integrase core domain; Region: rve_3; pfam13683 545693015177 Transposase; Region: HTH_Tnp_1; pfam01527 545693015178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 545693015179 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 545693015180 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015181 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015182 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015183 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015184 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015185 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693015186 Transposase, Mutator family; Region: Transposase_mut; cl19537 545693015187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 545693015188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 545693015189 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 545693015190 FAD binding domain; Region: FAD_binding_4; pfam01565 545693015191 Berberine and berberine like; Region: BBE; pfam08031 545693015192 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 545693015193 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 545693015194 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 545693015195 Homeobox prospero-like protein (PROX1); Region: Prox1; pfam05044 545693015196 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693015197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693015198 active site 545693015199 SPW repeat; Region: SPW; pfam03779 545693015200 Transposase, Mutator family; Region: Transposase_mut; cl19537 545693015201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 545693015202 Homeodomain-like domain; Region: HTH_23; pfam13384 545693015203 putative transposase OrfB; Reviewed; Region: PHA02517 545693015204 HTH-like domain; Region: HTH_21; pfam13276 545693015205 Integrase core domain; Region: rve; pfam00665 545693015206 Integrase core domain; Region: rve_3; pfam13683 545693015207 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 545693015208 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693015209 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693015210 Predicted membrane protein [Function unknown]; Region: COG2323 545693015211 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693015212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693015213 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693015214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693015215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 545693015216 Predicted transcriptional regulators [Transcription]; Region: COG1695 545693015217 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 545693015218 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693015219 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 545693015220 putative transposase, frameshift 545693015221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 545693015222 Homeodomain-like domain; Region: HTH_23; pfam13384 545693015223 putative transposase OrfB; Reviewed; Region: PHA02517 545693015224 HTH-like domain; Region: HTH_21; pfam13276 545693015225 Integrase core domain; Region: rve; pfam00665 545693015226 Integrase core domain; Region: rve_3; pfam13683 545693015227 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 545693015228 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 545693015229 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693015230 Helix-turn-helix domain; Region: HTH_36; pfam13730