-- dump date 20140618_223332 -- class Genbank::CDS -- table cds_note -- id note YP_001485261.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001485262.1 binds the polymerase to DNA and acts as a sliding clamp YP_001485264.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001485266.1 negatively supercoils closed circular double-stranded DNA YP_001485267.1 negatively supercoils closed circular double-stranded DNA YP_001485268.1 possible sigma-F transcribed protein YP_001485271.1 LdcC YP_001485272.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001485275.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001485276.1 possible stage 0 sporulation protein YP_001485277.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_001485280.1 tetrapyrrole (corrin/porphyrin) methylase YP_001485282.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001485286.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001485287.1 spore coat protein YabG YP_001485290.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001485293.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_001485294.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001485295.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001485296.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001485297.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001485302.1 MazG family protein YP_001485305.1 possible spore cortex biosynthesis protein YP_001485308.1 stage II sporulation phosphoprotein phosphatase YP_001485311.1 YacA YP_001485313.1 class III heat-shock protein; ATP-dependent zinc (Zn2+) protease YP_001485314.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001485315.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001485319.1 amphibolic enzyme subunit from Bacillus subtilis performs both in anthranilate and para-aminobenzoate synthesis YP_001485320.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001485322.1 YacE YP_001485325.1 Dus1 YP_001485326.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001485329.1 nucleotide excision repair protein YP_001485330.1 YacI YP_001485331.1 negative regulator of genetic competence MecB YP_001485332.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001485333.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair YP_001485335.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001485336.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001485337.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001485339.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001485343.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_001485344.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_001485345.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001485346.1 Modulates Rho-dependent transcription termination YP_001485347.1 binds directly to 23S ribosomal RNA YP_001485348.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001485349.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001485350.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001485353.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001485354.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001485355.1 in Bacillus subtilis this non-essential protein associates with the ribosome YP_001485356.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001485357.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001485358.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001485359.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001485361.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001485362.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001485363.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001485364.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001485365.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001485366.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001485367.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001485368.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001485369.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001485370.1 one of the stabilizing components for the large ribosomal subunit YP_001485371.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001485373.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001485374.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001485375.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_001485376.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001485377.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001485378.1 binds 5S rRNA along with protein L5 and L25 YP_001485379.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001485380.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001485381.1 late assembly protein YP_001485382.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001485383.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001485384.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001485385.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001485386.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001485387.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001485388.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001485389.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001485390.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001485391.1 with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene YP_001485392.1 with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene YP_001485394.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001485395.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001485396.1 forms a direct contact with the tRNA during translation YP_001485409.1 structural flagella protein YP_001485416.1 ybbH YP_001485417.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001485419.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: this protein is involved in detoxification and protection against antimicrobial YP_001485421.1 YbbQ YP_001485423.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001485424.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001485439.1 YbdP YP_001485440.1 glycerophosphoryl diester phosphodiesterase YbeD YP_001485443.1 possible lytic transglycosylase YomI YP_001485445.1 possible carboxypeptidase YP_001485456.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001485468.1 protein-N(pi)-phosphohistidine--sugar phosphotransferase SytA YP_001485479.1 possible subtilisin YP_001485483.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_001485491.1 possible subtilisin YP_001485497.1 AMP-dependent synthetase/ligase YP_001485500.1 S33 family non-peptidase YP_001485501.1 ybgH YP_001485502.1 catalyzes the formation of glutamate from glutamine YP_001485514.1 corex lytic enzyme YcbQ YP_001485522.1 citE YP_001485534.1 DcuC YP_001485535.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH YP_001485541.1 spore transporter YhjI YP_001485542.1 possible lysine exporter protein YP_001485547.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001485548.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001485554.1 acetyl xylan esterase YP_001485558.1 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate YP_001485559.1 possible transcriptional regulator YP_001485567.1 Competence protein ComJ YP_001485568.1 possible Amt family ammonium or ammonia transporter YP_001485569.1 competence-specific nuclease ComI YP_001485596.1 spore transporter YckK YP_001485611.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_001485617.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001485623.1 possible copper (Cu) resistance protein YP_001485625.1 possible PTS family mannitol porter component IIA YP_001485637.1 possible kinase inhibitor KipI YP_001485638.1 possible transcriptional regulator KipA YP_001485640.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001485641.1 YcsK YP_001485654.1 catalyzes the formation of oxaloglycolate from tartrate; also catalyzes the formation of pyruvate from malate and glycerate from tartrate YP_001485655.1 decatenates replicating daughter chromosomes YP_001485662.1 catalyzes the formation of acetyl phosphate from pyruvate YP_001485673.1 possible citrate/malate metabolism transcriptional regulator YdbG YP_001485674.1 involved in the transport of C4-dicarboxylates across the membrane YP_001485682.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001485686.1 sporulation-related DEAD-box helicase YP_001485690.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001485692.1 dal YP_001485693.1 possible transcriptional regulator YP_001485695.1 anti-sigma factor antagonist YcxR YP_001485697.1 switch protein, anti-sigma-B factor YP_001485698.1 sigma factor SigB regulation protein YP_001485699.1 anti-sigma-B factor antagonist YP_001485700.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme YP_001485701.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase YP_001485702.1 sigma B-dependent serine phosphatase YP_001485706.1 acetoin dehydrogenase E1 alpha subunit YP_001485707.1 acetoin dehydrogenase E1 beta subunit YP_001485708.1 acetoin dehydrogenase E2 subunit YP_001485709.1 E3 component of acetoin cleaving system; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001485712.1 S33 family serine peptidase YP_001485720.1 lincomycin resistance protein YP_001485721.1 S9C family serine non-peptidase homolog YP_001485730.1 multidrug-efflux transporter AcfA Bmr2 Bmt YP_001485738.1 histone acetyltransferase HPA2 and related acetyltransferases YP_001485759.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001485760.1 penicillin-binding protein 5 YP_001485762.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001485763.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_001485764.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001485767.1 yaaG YP_001485768.1 spore cortex-lytic enzyme, L-alanine-stimulated germination protein YaaH YP_001485770.1 possible cytidine/deoxycytidylate deaminase YP_001485771.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001485773.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001485776.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001485779.1 YdiD YP_001485780.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001485782.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001485783.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001485784.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001485789.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001485790.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001485796.1 Pig YP_001485797.1 gamma-aminobutyrate (GABA) permease YP_001485798.1 cation efflux protein YP_001485801.1 possible transglutaminase, cysteine protease YebA YP_001485802.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001485829.1 possible C40 family dipeptidyl peptidase VI YP_001485832.1 YdcL YP_001485849.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001485850.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001485851.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001485852.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway YP_001485853.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001485854.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001485855.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001485856.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001485857.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001485858.1 involved in de novo purine biosynthesis YP_001485859.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001485863.1 possible purine catabolism related protein YcgP YP_001485864.1 BioA YP_001485866.1 3-ketoacid CoA transferase YP_001485867.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_001485869.1 M38 family peptidase YP_001485875.1 YuzE YP_001485876.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer YP_001485878.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001485883.1 GrsT YP_001485884.1 YqiM YP_001485885.1 FkbH YP_001485886.1 possible acyl carrier protein YP_001485896.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001485897.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001485898.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001485902.1 similar to YegS from E. coli YP_001485962.1 acylphosphate phosphohydrolase YP_001485963.1 possible molybdenum cofactor sulphurase YP_001485966.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential YP_001485977.1 trehalose operon transcriptional repressor YP_001485978.1 in Escherichia coli this is a periplasmic enzyme while in gram positive organisms it may be anchored at the cell surface; this protein appears to consist of a dimer fusion; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001485986.1 possible stress response protein YP_001485998.1 yfjP YP_001485999.1 yfjO YP_001486005.1 possible chloramphenicol resistance protein YP_001486007.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); Bacillus have two copies of the threonyl-tRNA synthetase, threonine starvation induces both proteins YP_001486014.1 possible sortase YP_001486039.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001486042.1 SASP K; found in the forespore compartment YP_001486044.1 possible glycosyltransferase YP_001486054.1 YfhQ YP_001486056.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001486069.1 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate YP_001486070.1 bacterioferritin comigratory protein (BCP) YP_001486078.1 GpmB YP_001486083.1 MdoB YP_001486098.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_001486106.1 cspA YP_001486112.1 possible spore coat protein YP_001486116.1 23S rRNA-specific pseudouridylate synthase YhcT YP_001486121.1 possible glyoxalase YP_001486123.1 possible transcriptional regulator YP_001486125.1 glycerol uptake operon antiterminator regulatory protein YP_001486126.1 glycerol uptake facilitator protein YP_001486127.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001486129.1 YhxB YP_001486130.1 possible two-component regulatory protein YP_001486133.1 possible GNAT family acetyltransferase YP_001486140.1 phoAIV YP_001486141.1 C40 family murein endopeptidase; gamma-D-glutamate-meso-diaminopimelate muropeptidase CwlF; PapQ phosphatase-associated protein YP_001486143.1 possible transposase YP_001486144.1 possible regulator of SigM operon YP_001486145.1 possible regulator of SigM operon YP_001486146.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in B. subtilis this protein is activated in response to cell wall antibiotics, ethanol, heat, acid, and superoxide stress YP_001486147.1 YhdO YP_001486152.1 YhdU YP_001486153.1 YhdV YP_001486154.1 YhdW YP_001486158.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001486160.1 YheM YP_001486161.1 YheK YP_001486174.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001486176.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001486180.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates YP_001486188.1 hpr; ScoC; MarR family; protease production regulatory protein YP_001486192.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001486193.1 YhaE YP_001486198.1 M20D subfamily metallopeptidase YhaA YP_001486202.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001486203.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001486204.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_001486206.1 possible phage infection protein YP_001486207.1 spore protease YhfE YP_001486212.1 LplA YP_001486213.1 activates fatty acids by binding to coenzyme A YP_001486215.1 possible metalloprotease YP_001486216.1 S8 family serine protease YP_001486218.1 haem-based aerotactic transducer HemAT YP_001486220.1 alcohol dehydrogenase like protein YP_001486222.1 competence protein K YP_001486223.1 possible amino acid aldolase/racemase YncD YP_001486226.1 possible multidrug resistance efflux protein YP_001486237.1 recombination initiation protein AddB YP_001486238.1 recombination initiation protein AddA YP_001486240.1 YirY YP_001486249.1 spore coat assembly protein YwrH YP_001486250.1 possible spore coat protein G YP_001486263.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_001486266.1 possible acetyltransferase YP_001486267.1 possible siderophore biosynthesis protein YP_001486270.1 cobalamin-dependent methionine synthase YP_001486271.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions YP_001486272.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001486273.1 possible nucleic acid binding protein YP_001486276.1 DegV family protein YitS YP_001486284.1 possible FAD/FMN-containing oxidoreductase GlcD YP_001486286.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001486287.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001486288.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001486290.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001486291.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001486292.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001486294.1 possible macrolide-efflux protein YP_001486298.1 lipoprotein YjaW YP_001486301.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001486302.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001486312.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001486315.1 sporulation related transporter Spo0KB YP_001486321.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_001486322.1 TerC YP_001486323.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_001486324.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001486325.1 CoiA YP_001486326.1 PepF YP_001486334.1 catalyzes the phosphorylation of NAD to NADP YP_001486336.1 asymmetrical; catalyzes the formation of NTP and NMP from P(1),P(4)-bis(5'-nucleosyl) tetraphosphate; acts on bis(5'-guanosyl) tetraphosphate, bis(5'-xanthosyl)-tetraphosphate, on bis(5'-adenosyl)-tetraphosphate, and bis(5'-uridyl)-tetraphosphate YP_001486339.1 regulates the production of extracellular enzymes YP_001486341.1 thiamine biosynthesis protein YjbS YP_001486342.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001486343.1 catalyzes the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD or ThiS in the molybdopterin or thiamin pyrophosphate biosynthesis pathways YP_001486344.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001486345.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001486346.1 possible spore coat protein CotO YP_001486361.1 similar to 2'-5' RNA ligase YP_001486362.1 possible methylumbelliferyl-acetate deacetylase YP_001486363.1 catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity YP_001486364.1 catalyzes the formation of L-homocysteine from cystathionine YP_001486369.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001486390.1 YncD YP_001486393.1 structural flagella protein YP_001486394.1 structural flagella protein YP_001486395.1 structural flagella protein YP_001486396.1 structural flagella protein YP_001486398.1 possible ABC superfamily ATP binding cassette transporter, binding protein YP_001486401.1 phage PBSX protein YP_001486414.1 sorbitol dehydrogenase AdhC YP_001486415.1 pyruvate/2-oxoglutarate dehydrogenase complex E1 component alpha subunit AcoA YP_001486416.1 pyruvate/2-oxoglutarate dehydrogenase complex, E1 component, beta subunit AcoB YP_001486417.1 pyruvate/2-oxoglutarate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase AcoC YP_001486418.1 pyruvate/2-oxoglutarate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase AcoL YP_001486420.1 bacilysin biosynthesis oxidoreductase BacC YP_001486424.1 YkcA YP_001486425.1 S1 family serine protease YP_001486427.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001486436.1 YkfD YP_001486449.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001486451.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001486452.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001486457.1 possible redox protein OsmC YP_001486459.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001486479.1 possible tellurium resistance protein TerC YP_001486480.1 Heat shock-induced YP_001486481.1 YkrI YP_001486483.1 YkrK YP_001486484.1 putative metalloprotease YP_001486491.1 O-6-methylguanine-DNA-alkyltransferase YP_001486492.1 isomerizes methylthioribose-1-phosphate into methylthioribulose-1-phosphate; involved in methionine salvage pathway YP_001486493.1 phosphorylates methylthioribose to form methylthioribose-1-phosphate; involved in methionine salvage pathway YP_001486494.1 produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however YP_001486495.1 converts 2,3-diketo-5-methylthiopentyl-1-phosphate into 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate; involved in methionine salvage YP_001486496.1 converts 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate to 1,2-dihydroxy-3-keto-5-methylthiopentene; involved in methionine salvage YP_001486497.1 converts methylthioribulose-1-phosphate into 2,3-diketo-5-methylthiopentyl-1-phosphate; involved in methionine salvage YP_001486502.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001486503.1 With Mot B forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. YP_001486506.1 transcriptional regulator ExsB YP_001486507.1 YkvK YP_001486508.1 organic radical activating enzyme YP_001486509.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_001486517.1 thiol:disulfide interchange protein YkvV, thiol-disulfide oxidoreductase, StoA YP_001486520.1 YkvZ YP_001486522.1 protein-N(pi)-phosphohistidine--sugar phosphotransferase YP_001486526.1 spore photoproduct (thymine dimer) lyase YP_001486531.1 possible allergen V5/Tpx-1 protein YP_001486555.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001486559.1 hippurate hydrolase YP_001486567.1 catalyzes the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD or ThiS in the molybdopterin or thiamin pyrophosphate biosynthesis pathways YP_001486587.1 transcriptional regulator of stationary/sporulation gene expression YlxT YzaA YP_001486595.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001486597.1 YkrC YP_001486599.1 AceB YP_001486600.1 AceC YP_001486601.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001486602.1 Pal YP_001486604.1 Cad YP_001486606.1 YktB YP_001486611.1 YlaG YP_001486615.1 YlaK YP_001486617.1 catalyzes the formation of glutamate from glutamine YP_001486618.1 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; putative ligand binding protein YP_001486620.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_001486622.1 heme-containing membrane protein YP_001486623.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001486637.1 adenine-specific DNA methylase YP_001486638.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001486640.1 possible MFS family major facilitator transporter YP_001486641.1 PDZ domain protein YlbL YP_001486644.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001486645.1 DNA binding protein YlbO YP_001486647.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001486649.1 YllB YP_001486652.1 penicillin binding protein PbpB YP_001486654.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001486655.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001486656.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001486658.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001486659.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001486665.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001486666.1 bifunctional bacillopeptidase F/hypothetical protein YP_001486669.1 sigma-29; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell at the onset of sporulation YP_001486670.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed after engulfment; this factor is involved in the transcription of small acid-soluble proteins involved in protecting the forespore chromatin YP_001486680.1 possible Class III pyridoxal 5 YP_001486683.1 possible RNA-binding protein YP_001486685.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme YP_001486686.1 possible suppressor protein DnaK YP_001486687.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001486688.1 23S RNA-specific pseudouridylate synthase RluA YP_001486689.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001486691.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001486693.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001486694.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001486695.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+) YP_001486696.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits YP_001486697.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001486698.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001486701.1 ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms YP_001486703.1 YlnD YP_001486704.1 YlnE YP_001486705.1 ylnF YP_001486706.1 YloA YP_001486709.1 YlzA YP_001486710.1 Essential for recycling GMP and indirectly, cGMP YP_001486711.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001486712.1 YloI YP_001486713.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001486714.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001486716.1 sun protein YloM YP_001486717.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001486720.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001486721.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001486723.1 involved in the production of the spore cortex and coat YP_001486724.1 required for 70S ribosome assembly YP_001486729.1 catalyzes branch migration in Holliday junction intermediates YP_001486730.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria YP_001486731.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001486734.1 carries the fatty acid chain in fatty acid biosynthesis YP_001486735.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001486739.1 Sec family Type II general secretory pathway protein SRP54 YP_001486740.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001486743.1 Essential for efficient processing of 16S rRNA YP_001486744.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001486745.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001486746.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_001486747.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001486750.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001486751.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001486753.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001486754.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_001486755.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001486756.1 heat shock protein involved in degradation of misfolded proteins YP_001486757.1 heat shock protein involved in degradation of misfolded proteins YP_001486758.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_001486759.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001486760.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001486761.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001486762.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001486763.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001486764.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001486765.1 involved in type III protein export during flagellum assembly YP_001486766.1 rod/hook and filament chaperone YP_001486767.1 possible flagellar motor switch protein FliG YP_001486769.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod YP_001486770.1 makes up the distal portion of the flagellar basal body rod YP_001486772.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001486773.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001486774.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001486775.1 chemotaxis protein CheB YP_001486776.1 possible structural component of the flagellum that anchors the rod to the membrane YP_001486777.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001486778.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001486779.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001486780.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001486781.1 membrane protein involved in the flagellar export apparatus YP_001486782.1 positive regulator of class III flagellar genes YP_001486783.1 possible ParA ATPase YP_001486784.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001486788.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_001486789.1 expressed in late exponential phase; controls the expression of genes coding cell surface proteins involved in chemotaxis, flagellar assembly, and autolysis YP_001486791.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001486793.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001486794.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001486796.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001486797.1 RseP YP_001486798.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001486799.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_001486800.1 Family 9 glycoside hydrolase CelA YP_001486801.1 Family 48 glycoside hydrolase YP_001486803.1 Family 5 glycoside hydrolase YdhT YP_001486804.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001486805.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001486808.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001486810.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001486811.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001486812.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001486813.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001486817.1 aminoglycoside phosphotransferase YP_001486818.1 possible PRC-barrel domain protein YP_001486819.1 catalyzes the synthesis of dipicolinic acid from dihydroxydipicolinic acid; plays a role in spore heat resistance YP_001486820.1 involved in production of dipicolinic acid (pyridine-2,6-dicarboxylic acid, DPA) which is synthesized late in sporulation in the mother cell and accumulates in the spore; mutations in this gene result in a lack of DPA synthesis; presumably functions with SpoVFA to form the synthase enzyme YP_001486821.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001486822.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive YP_001486823.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001486825.1 TepA YP_001486829.1 YdgH YP_001486830.1 YmfG YP_001486831.1 YmfH YP_001486834.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001486836.1 YmfK YP_001486840.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001486841.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_001486845.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001486846.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001486847.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001486850.1 This protein performs the mismatch recognition step during the DNA repair process YP_001486851.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001486857.1 aspartate phosphatase response regulator YP_001486866.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001486867.1 Stimulates the elongation of poly(A) tails YP_001486870.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001486871.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001486872.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001486875.1 SpoVJ YP_001486876.1 YnbA YP_001486901.1 collagen triple helix protein YP_001486905.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_001486906.1 Ku YP_001486908.1 possible fosfomycin resistance protein YP_001486909.1 possible rrf2 transcriptional regulator YP_001486916.1 possible PP2A phosphatase YP_001486917.1 possible AcrR family transcriptional regulator YP_001486919.1 extracellular metalloprotease YP_001486924.1 Represses a number of genes involved in the response to DNA damage YP_001486926.1 possible resolvase YP_001486929.1 YoxF YP_001486930.1 YoxG YP_001486932.1 stage V sporulation thiol-disulfide oxidoreductase CcdA, DsbD family membrane protein YP_001486933.1 cytochrome c defective protein YoxI CcdC YP_001486935.1 CotL YP_001486936.1 SASP O; found in forespore compartment YP_001486937.1 Catalyzes the conversion of citrate to isocitrate YP_001486938.1 possible thioredoxin YP_001486940.1 SASP N; found in forespore compartment YP_001486945.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001486947.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001486948.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001486955.1 possible NAD(P)H dehydrogenase (quinone) YP_001486958.1 YjgH YP_001486969.1 blasticidin S deaminase YP_001486973.1 possible beta-glucosidase YP_001486980.1 xylanase D YP_001486988.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001486989.1 PTS system, lactose/cellobiose specific IIB subunit YP_001487001.1 PTS system, fructose-specific enzyme II, BC component YP_001487009.1 YvgR YP_001487010.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001487014.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_001487027.1 spore germination protein B YP_001487032.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_001487033.1 GPR1/FUN34/yaaH family protein YP_001487037.1 yoeA YP_001487038.1 S13 family carboxypeptidase YP_001487044.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001487049.1 multidrug-efflux transporter 2 regulator bmr2R bmtR YP_001487054.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001487055.1 YoxE YP_001487056.1 YjiB YP_001487060.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001487066.1 YndJ YP_001487078.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_001487079.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle, glyoxylate cycle and respiration YP_001487092.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001487093.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001487097.1 YojJ YP_001487098.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001487100.1 YojF YP_001487102.1 YojE YP_001487111.1 YodH YP_001487113.1 M15 family peptidase YP_001487114.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001487130.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001487131.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001487141.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_001487146.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001487147.1 YpjQ YP_001487152.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001487156.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001487157.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001487158.1 processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids YP_001487169.1 YpbR YP_001487173.1 xanthine permease YP_001487175.1 carboxypeptidase Taq YP_001487180.1 YpsC YP_001487181.1 GpsB; guiding PBP1 shuttling; similar to DivIVA YP_001487183.1 possible exonuclease YP_001487193.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_001487198.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001487201.1 unwinds DNA YP_001487202.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001487204.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001487205.1 bifunctional biotin repressor/biotin--[acetyl-CoA-carboxylase] ligase YP_001487206.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_001487207.1 YpjH YP_001487210.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001487216.1 electron transport protein YP_001487221.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001487222.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_001487223.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001487224.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001487225.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001487226.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_001487227.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001487228.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001487229.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001487231.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001487232.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001487236.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001487237.1 GerCA, HepA YP_001487238.1 tryptophan RNA-binding attenuator protein; binds leader Trp transcript causing transcription termination YP_001487239.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001487240.1 signal recognition particle-like (SRP) component DbpA HupA HbsU YP_001487241.1 stage IV sporulation protein A SpoVP YP_001487242.1 JohF YP_001487244.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001487245.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001487247.1 YphB YP_001487250.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001487251.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001487252.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001487253.1 JofB YP_001487254.1 possible glycosyltransferase JofA YP_001487255.1 JoeB YzuA YP_001487256.1 YpeA YP_001487258.1 possible FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001487259.1 NAD-specific glutamate dehydrogenase YpcA YP_001487260.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_001487263.1 possible LysM family protein YP_001487264.1 possible prenyl protease YP_001487265.1 RecS, YpbC YP_001487269.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001487272.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in B. subtilis has been shown to regulate cell envelope modification and may effect antibiotic resistance YP_001487278.1 catalyzes the reduction of the disulfide bonds in the heme binding site of apocytochrome c YP_001487285.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB YP_001487289.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001487291.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001487294.1 AcrR YP_001487306.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the prespore at the onset of sporulation. Interaction with spoIIAB inhibits sigma F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. YP_001487307.1 binds to sigma F preventing its association with RNA polymerase during sporulation YP_001487308.1 stage II sporulation protein AA, antagonist of SpoIIAB YP_001487309.1 S11 family D-Ala-D-Ala serine carboxypeptidase YP_001487310.1 DeoD YqkO Pnp YP_001487311.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001487312.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001487328.1 possible GrpB family protein YP_001487329.1 possible GNAT family acetyltransferase YP_001487331.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001487332.1 YqjX YP_001487333.1 YqjV YP_001487334.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001487335.1 FAD-dependent pyridine nucleotide-disulfide oxidoreductase/NADH dehydrogenase YP_001487340.1 possible arginine degradation protein RocB YP_001487341.1 catalyzes the reduction of alpha, beta-unsaturated aldehydes and ketones; reduces the nitro group nitroester and nitroaromatic compounds YP_001487344.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001487345.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001487348.1 spore transporter YdhO YP_001487351.1 Converts glucose to D-glucono-1,5 lactone YP_001487352.1 glucose uptake protein YcxE YP_001487353.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001487354.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001487357.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site YP_001487371.1 BkdB YP_001487372.1 BkdA2 YP_001487373.1 BkdA1 YP_001487374.1 E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001487375.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate YP_001487376.1 YqiT YP_001487377.1 catalyzes the synthesis of butanoylphosphate from butanoyl-CoA and inorganic phosphate YP_001487378.1 sigma L-dependent transcriptional regulator YP_001487386.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001487388.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001487390.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001487391.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001487392.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001487393.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001487395.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001487396.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001487403.1 necessary for complete engulfment of forespore YP_001487406.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001487408.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001487413.1 involved in manganese homeostasis; activates the transcription of the mntABCD operon YP_001487414.1 YqhM YP_001487415.1 possible rhodanese homology domain containing protein YP_001487416.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_001487417.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_001487418.1 glycine cleavage system protein T YP_001487419.1 possible DEAD/DEAH box helicase YP_001487423.1 spore coat-associated protein TasA,YqhF YP_001487432.1 exogenous DNA-binding protein YP_001487435.1 possible stage II sporulation anti-anti-sigma factor SpoIIAA YP_001487438.1 possible zinc (Zn) dependent hydrolase YP_001487442.1 possible zinc (Zn) peptidase YP_001487443.1 MdoB YP_001487444.1 transcriptional regulator NagC YP_001487446.1 possible rhomboid family protease YP_001487449.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001487452.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001487453.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001487457.1 cell division protein FtsI YP_001487463.1 possible LysM family peptidoglycan catabolism protein YP_001487464.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001487470.1 zinc-specific metalloregulatory protein YqfV YP_001487475.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001487478.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001487480.1 possible S-adenosylmethionine (SAM)-dependent methyltransferase YP_001487482.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_001487483.1 synthesizes RNA primers at the replication forks YP_001487484.1 YqfM YP_001487486.1 possible CBS domain protein YP_001487487.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001487488.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001487489.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001487491.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001487494.1 possible metal-dependent phosphohydrolase YP_001487495.1 YqfE YP_001487501.1 possible membrane-bound ClpP family serine protease YP_001487503.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001487505.1 YqeV YP_001487506.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001487507.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001487508.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001487509.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001487510.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001487511.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_001487512.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001487513.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001487514.1 YqxA YP_001487516.1 Initiates the rapid degradation of small, acid-soluble proteins during spore germination YP_001487517.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001487518.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001487520.1 possible integral membrane protein YP_001487521.1 competence protein EB YP_001487523.1 may be involved in regulation of competence genes YP_001487524.1 UbiE YP_001487527.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001487529.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001487530.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_001487538.1 sigma-28; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell after engulfment YP_001487553.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001487554.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001487561.1 possible lipase/esterase YP_001487566.1 penicillin binding protein transpeptidase YP_001487576.1 class IV alcohol dehydrogenase, iron-containing alcohol dehydrogenase, GbsB EutG YP_001487580.1 YrkN YP_001487586.1 catalyzes the formation of L-homocysteine from cystathionine YP_001487588.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001487593.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001487595.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001487600.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001487601.1 activates fatty acids by binding to coenzyme A YP_001487602.1 BioY family protein YP_001487604.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001487606.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001487607.1 possible permease YP_001487615.1 YrrC YP_001487617.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001487622.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001487624.1 YrvJ YP_001487627.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001487628.1 yrvE YP_001487630.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001487635.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001487636.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001487637.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001487639.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001487640.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001487641.1 forespore regulator of the sigma-K checkpoint YP_001487645.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001487648.1 spore coat assembly protein YrbA YP_001487649.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001487650.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001487651.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001487653.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001487655.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001487657.1 involved in the peptidyltransferase reaction during translation YP_001487661.1 inhibitor of stage IV sporulation protein FB YP_001487662.1 ATPase activator of MinC YP_001487663.1 blocks the formation of polar Z-ring septums YP_001487665.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001487666.1 functions in MreBCD complex in some organisms YP_001487667.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001487668.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001487670.1 ComC protein YP_001487672.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001487675.1 stage VI sporulation protein D YP_001487676.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001487677.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001487679.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001487681.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001487683.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001487686.1 binds and unfolds substrates as part of the ClpXP protease YP_001487687.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001487689.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001487690.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001487691.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001487692.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001487693.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001487694.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001487695.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001487696.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001487699.1 D-alanine esterification of lipoteichoic acid and wall teichoic protein YP_001487700.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_001487701.1 D-alanine esterification of lipoteichoic acid and wall teichoic protein YP_001487702.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_001487710.1 short-chain alcohol dehydrogenase YP_001487712.1 hydrolyzes non-standard nucleotides such as xanthine and inosine YP_001487713.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001487715.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001487717.1 transcriptional regulator of spore coat genes YP_001487718.1 YraO YP_001487720.1 DUF485/possible polyaromatic hydrocarbon fluorene degradation protein YP_001487722.1 possible 4-hydroxybenzoyl-CoA thioesterase YP_001487723.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001487724.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001487727.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001487728.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001487733.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001487738.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_001487740.1 possible Colicin V production protein YP_001487742.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001487743.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001487744.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001487752.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001487754.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases YP_001487755.1 negatively regulates murein hydrolase activity YP_001487760.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001487763.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_001487764.1 replication initiation and membrane attachment protein YP_001487766.1 Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001487767.1 NADP-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during gluconeogenesis YP_001487768.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001487770.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001487771.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001487774.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_001487775.1 Converts isocitrate to alpha ketoglutarate YP_001487776.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_001487780.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001487781.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001487782.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001487783.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001487784.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001487786.1 catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. YP_001487793.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins YP_001487794.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001487796.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001487797.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001487798.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001487800.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001487804.1 periplasmic serine protease YP_001487805.1 catalyzes the phosphorylation of NAD to NADP YP_001487808.1 YocF YP_001487810.1 YxeB YP_001487813.1 BceA YP_001487814.1 BceB YP_001487821.1 Required for the synthesis of the thiazole moiety YP_001487824.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_001487825.1 catalyzes the formation of L-histidinol from L-histidinol phosphate YP_001487828.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001487833.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001487834.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001487838.1 catabolite control protein A YP_001487839.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate YP_001487844.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001487849.1 possible PfoR family toxin regulator YP_001487851.1 M42 family peptidase YP_001487853.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001487855.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001487863.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_001487882.1 Ara1 YP_001487886.1 possible S09C acylaminoacyl peptidase YP_001487887.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001487894.1 possible CcmAABC superfamily ATP binding cassette transporter, ABC protein YP_001487901.1 possible PldB family lysophospholipase YP_001487902.1 possible PaaY family carbonic anhydrase YP_001487904.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001487905.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001487918.1 possible hydrolase YP_001487919.1 possible phage holin YP_001487921.1 YtkB YP_001487923.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001487927.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001487928.1 YthA YP_001487933.1 converts O-succinylbenzoate to O-succinylbenzoyl-CoA YP_001487934.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001487936.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001487938.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001487940.1 YteA YP_001487941.1 YtaB YP_001487942.1 YuaJ YP_001487944.1 YuaI YP_001487946.1 possible stage V sporulation protein E SpoVE YP_001487955.1 YkrP YP_001487957.1 possible bacteriocin precursor YP_001487970.1 XkdQ YP_001487979.1 XkdJ YP_001487980.1 XkdI YP_001487984.1 XkdF YP_001487985.1 XkdE YP_001487988.1 Positive regulatory protein that acts at the late promoter PL YP_001487995.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_001487997.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001488000.1 YulF YP_001488007.1 involved in assembly of spore coat proteins such as GerQ by catalyzing epsilon-(gamma-glutamyl)lysine cross links YP_001488011.1 YugS YP_001488014.1 YugO YP_001488017.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001488020.1 YuzA YP_001488021.1 induced by heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation YP_001488023.1 YugG YP_001488024.1 YugF YP_001488030.1 inhibitor of the KinA pathway of sporulation YP_001488035.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_001488044.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001488045.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport YP_001488046.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001488047.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001488048.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001488049.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001488050.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001488057.1 YuzC YP_001488059.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001488062.1 YueF YP_001488077.1 stage V sporulation protein N SpoVN YP_001488078.1 YuiG YP_001488080.1 YuiF YP_001488081.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001488083.1 YuiD YP_001488084.1 YuiC YP_001488085.1 YuiB YP_001488086.1 YuiA YP_001488088.1 YumC YP_001488092.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001488094.1 YuzB YP_001488096.1 YutJ YP_001488098.1 YuzD YP_001488099.1 YutI YP_001488100.1 Dipeptidyl aminopeptidase/acylaminoacyl-peptidase Dap2 YP_001488101.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001488102.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001488103.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001488105.1 YutH YP_001488106.1 YutG YP_001488107.1 YutF YP_001488108.1 YutE YP_001488109.1 YutD YP_001488110.1 YutC YP_001488111.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001488115.1 YunC YP_001488116.1 YunD YP_001488117.1 YunF YP_001488121.1 YurG YP_001488124.1 YfhA YP_001488125.1 YfiZ YP_001488126.1 YfiY YP_001488130.1 YrkQ YP_001488131.1 YrkP YP_001488133.1 YrkO YP_001488137.1 FeS cluster assembly protein YP_001488140.1 FeS cluster assembly protein YurX YP_001488141.1 FeS cluster assembly protein YurY YP_001488143.1 YurZ YP_001488144.1 YusA YP_001488145.1 YusB YP_001488146.1 YusC YP_001488148.1 YusD YP_001488149.1 YusE YP_001488151.1 YusG YP_001488153.1 YusI YP_001488154.1 YusJ YP_001488155.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001488156.1 YusL YP_001488159.1 YusN YP_001488162.1 YusU YP_001488163.1 YusV YP_001488164.1 YusW YP_001488165.1 YusZ YP_001488166.1 YvtA YP_001488170.1 YuxN YP_001488171.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001488177.1 YvqC YP_001488178.1 YvqE YP_001488179.1 YvqF YP_001488180.1 YvqG YP_001488181.1 YvqH YP_001488182.1 YvqI YP_001488183.1 YvqK YP_001488188.1 possible sigma-L-dependent transcriptional regulator YP_001488193.1 YvrA YP_001488194.1 YvrB YP_001488195.1 YvrC YP_001488199.1 catalyzes the formation of D-tagaturonate from D-altronate YP_001488201.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001488202.1 YvrG YP_001488203.1 YvrH YP_001488209.1 YvsH YP_001488214.1 YvsG YP_001488215.1 YvgJ YP_001488216.1 YvgL YP_001488218.1 YvgN YP_001488220.1 YvgP YP_001488221.1 YvgT YP_001488228.1 YmcC YP_001488232.1 catalyzes the formation of fumarate from aspartate YP_001488236.1 CopZ YP_001488237.1 YvgZ YP_001488238.1 YybP YP_001488240.1 GGDEF domain containing protein YP_001488244.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001488267.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001488268.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001488269.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001488270.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001488276.1 YvfI YP_001488278.1 YvfG YP_001488285.1 polysaccharide biosynthesis protein YvfE YP_001488286.1 YvfD YP_001488287.1 YvfC YP_001488289.1 YveS YP_001488290.1 YveR YP_001488291.1 YveQ YP_001488292.1 YveP YP_001488293.1 YveO YP_001488294.1 YveN YP_001488295.1 YveM YP_001488296.1 YveL YP_001488297.1 YveK YP_001488304.1 YjeA YP_001488311.1 YdhE YP_001488316.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001488317.1 YvdD YP_001488318.1 YvdC YP_001488319.1 YvdB YP_001488320.1 YvdA YP_001488322.1 YvcT YP_001488324.1 barnase YP_001488325.1 YvcN YP_001488327.1 YvcL YP_001488328.1 YvcK YP_001488329.1 YvcJ YP_001488333.1 YvcE YP_001488335.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001488336.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001488337.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001488338.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001488339.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001488340.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001488341.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_001488342.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_001488348.1 hydrolyzes pyrophosphate formed during serine-46-phosphorylated HPr dephosphorylation YP_001488349.1 YvoD YP_001488350.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001488351.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_001488354.1 YvoA YP_001488355.1 YvnB YP_001488356.1 YvlD YP_001488357.1 YvlC YP_001488358.1 YvlB YP_001488359.1 YvlA YP_001488360.1 YkvN YP_001488361.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001488362.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001488365.1 YvkC YP_001488366.1 YvkB YP_001488367.1 YvkA YP_001488369.1 YclJ YP_001488371.1 YkcB YP_001488372.1 YkcC YP_001488373.1 YvbW YP_001488375.1 YfkO YP_001488376.1 YdeP YP_001488378.1 possible swarming motility protein YvzD YP_001488380.1 YvjB YP_001488381.1 YdhB YP_001488387.1 YvjA YP_001488392.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001488393.1 Protein Y YP_001488397.1 flagellin specific chaperone YP_001488398.1 involved in flagellin assembly YP_001488399.1 possibly involved in flagella export YP_001488400.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001488401.1 binds to flagellin and appears to stabilize flagellin during flagella assembly YP_001488402.1 YviE YP_001488403.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook YP_001488404.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001488406.1 anti-sigma-28 factor YP_001488407.1 YvyF YP_001488411.1 YviA YP_001488414.1 YvyE YP_001488415.1 YvhJ YP_001488416.1 TagO YP_001488418.1 YvhG YP_001488420.1 possible lipopolysaccharide biosynthesis protein TuaE YP_001488427.1 major autolysin LytC YP_001488430.1 attenuator function for control of operon expression YP_001488431.1 YvyH YP_001488433.1 with TagG is involved in the export of teichoic acids YP_001488438.1 teichoic acid biosynthesis protein F YP_001488443.1 teichoic acid synthase YP_001488444.1 teichoic acid synthase YP_001488445.1 teichoic acid synthase YP_001488459.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001488460.1 Involved in the metabolism of 2-deoxyglucose YP_001488461.1 spore germination protein B1 YP_001488465.1 sugar transporter YP_001488468.1 gamma-glutamyl DD-amidohydrolase, poly-gamma-glutamate hydrolase PgdS YP_001488470.1 PgsA YP_001488471.1 PgsC YP_001488472.1 gamma-polyglutamic acid synthetase PgsB CapB YP_001488484.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_001488492.1 HepA YP_001488498.1 large conductance mechanosensitive channel protein YwpC YP_001488506.1 possible quinolone resistance protein YP_001488507.1 possible acid phosphatase/vanadium-dependent haloperoxidase BcrC YP_001488509.1 PbpB YP_001488516.1 phosphinothricin acetyltransferase YP_001488518.1 possible methylamine utilisation protein MauE YP_001488523.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001488525.1 YhzA YP_001488527.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001488528.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001488531.1 possible D-amino acid dehydrogenase, large subunit YP_001488532.1 possible D-amino acid dehydrogenase, large subunit YP_001488534.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001488538.1 proton (H+) translocating F-type ATPase (F-ATPase), F(1) epsilon subunit YP_001488539.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001488540.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001488541.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001488542.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001488543.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001488544.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001488545.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001488546.1 proton (H+) translocating F-type ATPase (F-ATPase), F(0) subunit I YP_001488547.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001488548.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001488550.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_001488553.1 possible translation protein YwlC YP_001488554.1 possible acyl-CoA N-acyltransferase YP_001488557.1 YwkE YP_001488558.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001488559.1 remodeling and anchoring of the chromosome protein; in Bacillus subtilis this protein functions in polar chromosome segregation during sporulation; binds inverted sequence motifs called ram along the chromosome; condenses DNA via RacA-RacA interactions YP_001488561.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001488562.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001488563.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001488565.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001488566.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001488568.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001488569.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis YP_001488572.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001488573.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_001488575.1 lantibiotic immunity protein LanH YP_001488588.1 YwjD YP_001488593.1 possible microcin immunity protein YP_001488595.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001488599.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001488608.1 prespore-specific transcriptional regulator YP_001488612.1 YwfL YP_001488626.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001488631.1 ywfB YP_001488632.1 ywfC YP_001488633.1 oxidoreductase YwfD YP_001488634.1 alanine-anticapsin ligase YwfE YP_001488635.1 produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however YP_001488637.1 dTDP-4-dehydrorhamnose 3,5-epimerase RfbC YP_001488638.1 dTDP-4-dehydrorhamnose reductase RfbD YP_001488639.1 dTDP-D-glucose 4,6-dehydratase RfbB YP_001488643.1 sialic acid synthase YP_001488649.1 YwdL YP_001488650.1 possible cupin family protein YP_001488654.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001488658.1 catalyzes the phosphorylation of three vitamin B6 precursors, pyridoxal, pyridoxine and pyridoxamine YP_001488661.1 sucrose-6-phosphate hydrolase O-Glycosyl hydrolase YP_001488662.1 protein-N(pi)-phosphohistidine--sugar phosphotransferase YP_001488663.1 possible PTS family fructose/mannitol (fru) porter component II YP_001488665.1 subtilisin-like extracellular serine protease AprE YP_001488668.1 FMN-containing NADPH-linked nitro/flavin reductase YP_001488669.1 YwcF YP_001488676.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism YP_001488677.1 cell envelope biogenesis protein YP_001488678.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001488679.1 possible arabinose operon control protein YP_001488683.1 StrF YP_001488685.1 aspartate phosphatase response regulator Rap40 YqcH YP_001488693.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001488694.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001488696.1 increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation; inhibited by the antiholin-like proteins lrgAB YP_001488697.1 possible peptidoglycan hydrolase YP_001488704.1 possible AraH ABC superfamily ATP binding cassette transporter, membrane protein YP_001488707.1 YwoF YP_001488708.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001488712.1 protein-N(pi)-phosphohistidine--sugar phosphotransferase YP_001488714.1 protein-N(pi)-phosphohistidine--sugar phosphotransferase YP_001488719.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001488722.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001488743.1 YdhP YP_001488745.1 possible LicABCH operon regulator CelR YP_001488751.1 catalyzes the formation of fumarate from aspartate YP_001488753.1 ans operon repressor protein YP_001488754.1 helix-turn-helix domain protein YP_001488759.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001488763.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_001488766.1 YxjG YP_001488785.1 possible antibiotic biosynthesis monooxygenase YP_001488789.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway YP_001488791.1 Dra YP_001488792.1 YxxC YP_001488797.1 possible UbiE family methyltransferase YP_001488799.1 possible HAD superfamily hydrolase YP_001488801.1 YulF YP_001488817.1 YvfK YP_001488825.1 spore transporter YhcH YP_001488834.1 YxaA YP_001488836.1 possible transcriptional regulator CdaR YP_001488837.1 AcrR family transcriptional regulator YP_001488848.1 protein-N(pi)-phosphohistidine--sugar phosphotransferase SytA YP_001488856.1 AnsP YdgF YP_001488857.1 PurR YP_001488867.1 PhnF YP_001488880.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001488881.1 YbaF YP_001488888.1 YycK YP_001488897.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001488899.1 YjiB YP_001488900.1 possible glyoxalase YP_001488901.1 unwinds double stranded DNA YP_001488908.1 YycB YP_001488909.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001488912.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001488916.1 YxlI YP_001488919.1 glyoxalase/bleomycin resistance protein YP_001488922.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001488924.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001488925.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001488934.1 stage 0 sporulation protein J YP_001488935.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001488936.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001488937.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001488939.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; necessary for sporulation YP_001488940.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates