-- dump date 20140618_223331 -- class Genbank::misc_feature -- table misc_feature_note -- id note 315750000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 315750000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 315750000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000004 Walker A motif; other site 315750000005 ATP binding site [chemical binding]; other site 315750000006 Walker B motif; other site 315750000007 arginine finger; other site 315750000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 315750000009 DnaA box-binding interface [nucleotide binding]; other site 315750000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 315750000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 315750000012 putative DNA binding surface [nucleotide binding]; other site 315750000013 dimer interface [polypeptide binding]; other site 315750000014 beta-clamp/clamp loader binding surface; other site 315750000015 beta-clamp/translesion DNA polymerase binding surface; other site 315750000016 S4 domain; Region: S4_2; pfam13275 315750000017 recombination protein F; Reviewed; Region: recF; PRK00064 315750000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 315750000019 Walker A/P-loop; other site 315750000020 ATP binding site [chemical binding]; other site 315750000021 Q-loop/lid; other site 315750000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750000023 ABC transporter signature motif; other site 315750000024 Walker B; other site 315750000025 D-loop; other site 315750000026 H-loop/switch region; other site 315750000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 315750000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750000029 ATP binding site [chemical binding]; other site 315750000030 Mg2+ binding site [ion binding]; other site 315750000031 G-X-G motif; other site 315750000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315750000033 anchoring element; other site 315750000034 dimer interface [polypeptide binding]; other site 315750000035 ATP binding site [chemical binding]; other site 315750000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315750000037 active site 315750000038 putative metal-binding site [ion binding]; other site 315750000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315750000040 DNA gyrase subunit A; Validated; Region: PRK05560 315750000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 315750000042 CAP-like domain; other site 315750000043 active site 315750000044 primary dimer interface [polypeptide binding]; other site 315750000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000051 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 315750000052 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 315750000053 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315750000054 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315750000055 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 315750000056 homodimer interface [polypeptide binding]; other site 315750000057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000058 catalytic residue [active] 315750000059 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315750000060 thymidylate kinase; Validated; Region: tmk; PRK00698 315750000061 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 315750000062 TMP-binding site; other site 315750000063 ATP-binding site [chemical binding]; other site 315750000064 Protein of unknown function (DUF970); Region: DUF970; pfam06153 315750000065 Protein of unknown function (DUF327); Region: DUF327; pfam03885 315750000066 DNA polymerase III subunit delta'; Validated; Region: PRK08058 315750000067 DNA polymerase III subunit delta'; Validated; Region: PRK08485 315750000068 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 315750000069 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 315750000070 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 315750000071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750000072 S-adenosylmethionine binding site [chemical binding]; other site 315750000073 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 315750000074 GIY-YIG motif/motif A; other site 315750000075 putative active site [active] 315750000076 putative metal binding site [ion binding]; other site 315750000077 Predicted methyltransferases [General function prediction only]; Region: COG0313 315750000078 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 315750000079 putative SAM binding site [chemical binding]; other site 315750000080 putative homodimer interface [polypeptide binding]; other site 315750000081 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 315750000082 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315750000083 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 315750000084 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 315750000085 active site 315750000086 HIGH motif; other site 315750000087 KMSKS motif; other site 315750000088 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 315750000089 tRNA binding surface [nucleotide binding]; other site 315750000090 anticodon binding site; other site 315750000091 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 315750000092 putative tRNA-binding site [nucleotide binding]; other site 315750000093 dimer interface [polypeptide binding]; other site 315750000094 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 315750000095 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 315750000096 active site 315750000097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 315750000098 Domain of unknown function (DUF348); Region: DUF348; pfam03990 315750000099 Domain of unknown function (DUF348); Region: DUF348; pfam03990 315750000100 Domain of unknown function (DUF348); Region: DUF348; pfam03990 315750000101 G5 domain; Region: G5; pfam07501 315750000102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315750000103 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 315750000104 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 315750000105 putative active site [active] 315750000106 putative metal binding site [ion binding]; other site 315750000107 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 315750000108 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 315750000109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750000110 S-adenosylmethionine binding site [chemical binding]; other site 315750000111 YabG peptidase U57; Region: Peptidase_U57; pfam05582 315750000112 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 315750000113 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750000114 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 315750000115 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315750000116 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315750000117 pur operon repressor; Provisional; Region: PRK09213 315750000118 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 315750000119 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750000120 active site 315750000121 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750000122 homotrimer interaction site [polypeptide binding]; other site 315750000123 putative active site [active] 315750000124 regulatory protein SpoVG; Reviewed; Region: PRK13259 315750000125 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 315750000126 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 315750000127 Substrate binding site; other site 315750000128 Mg++ binding site; other site 315750000129 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 315750000130 active site 315750000131 substrate binding site [chemical binding]; other site 315750000132 CoA binding site [chemical binding]; other site 315750000133 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 315750000134 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 315750000135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750000136 active site 315750000137 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 315750000138 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 315750000139 5S rRNA interface [nucleotide binding]; other site 315750000140 CTC domain interface [polypeptide binding]; other site 315750000141 L16 interface [polypeptide binding]; other site 315750000142 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 315750000143 putative active site [active] 315750000144 catalytic residue [active] 315750000145 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 315750000146 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 315750000147 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 315750000148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750000149 ATP binding site [chemical binding]; other site 315750000150 putative Mg++ binding site [ion binding]; other site 315750000151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750000152 nucleotide binding region [chemical binding]; other site 315750000153 ATP-binding site [chemical binding]; other site 315750000154 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 315750000155 stage V sporulation protein T; Region: spore_V_T; TIGR02851 315750000156 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 315750000157 GAF domain; Region: GAF; cl17456 315750000158 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315750000159 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315750000160 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 315750000161 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 315750000162 putative SAM binding site [chemical binding]; other site 315750000163 putative homodimer interface [polypeptide binding]; other site 315750000164 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 315750000165 homodimer interface [polypeptide binding]; other site 315750000166 metal binding site [ion binding]; metal-binding site 315750000167 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 315750000168 homodimer interface [polypeptide binding]; other site 315750000169 active site 315750000170 putative chemical substrate binding site [chemical binding]; other site 315750000171 metal binding site [ion binding]; metal-binding site 315750000172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750000173 RNA binding surface [nucleotide binding]; other site 315750000174 sporulation protein YabP; Region: spore_yabP; TIGR02892 315750000175 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 315750000176 Septum formation initiator; Region: DivIC; cl17659 315750000177 hypothetical protein; Provisional; Region: PRK08582 315750000178 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 315750000179 RNA binding site [nucleotide binding]; other site 315750000180 stage II sporulation protein E; Region: spore_II_E; TIGR02865 315750000181 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 315750000182 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 315750000183 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 315750000184 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 315750000185 metal ion-dependent adhesion site (MIDAS); other site 315750000186 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 315750000187 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315750000188 active site 315750000189 ATP binding site [chemical binding]; other site 315750000190 substrate binding site [chemical binding]; other site 315750000191 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 315750000192 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 315750000193 Ligand Binding Site [chemical binding]; other site 315750000194 TilS substrate C-terminal domain; Region: TilS_C; smart00977 315750000195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750000196 active site 315750000197 FtsH Extracellular; Region: FtsH_ext; pfam06480 315750000198 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 315750000199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000200 Walker A motif; other site 315750000201 ATP binding site [chemical binding]; other site 315750000202 Walker B motif; other site 315750000203 arginine finger; other site 315750000204 Peptidase family M41; Region: Peptidase_M41; pfam01434 315750000205 pantothenate kinase; Reviewed; Region: PRK13318 315750000206 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 315750000207 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 315750000208 dimerization interface [polypeptide binding]; other site 315750000209 domain crossover interface; other site 315750000210 redox-dependent activation switch; other site 315750000211 SurA N-terminal domain; Region: SurA_N_3; cl07813 315750000212 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 315750000213 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315750000214 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315750000215 dimer interface [polypeptide binding]; other site 315750000216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000217 catalytic residue [active] 315750000218 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 315750000219 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315750000220 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 315750000221 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 315750000222 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 315750000223 glutamine binding [chemical binding]; other site 315750000224 catalytic triad [active] 315750000225 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315750000226 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 315750000227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000228 catalytic residue [active] 315750000229 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 315750000230 dihydropteroate synthase; Region: DHPS; TIGR01496 315750000231 substrate binding pocket [chemical binding]; other site 315750000232 dimer interface [polypeptide binding]; other site 315750000233 inhibitor binding site; inhibition site 315750000234 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 315750000235 homooctamer interface [polypeptide binding]; other site 315750000236 active site 315750000237 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 315750000238 catalytic center binding site [active] 315750000239 ATP binding site [chemical binding]; other site 315750000240 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750000241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750000242 non-specific DNA binding site [nucleotide binding]; other site 315750000243 salt bridge; other site 315750000244 sequence-specific DNA binding site [nucleotide binding]; other site 315750000245 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 315750000246 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315750000247 FMN binding site [chemical binding]; other site 315750000248 active site 315750000249 catalytic residues [active] 315750000250 substrate binding site [chemical binding]; other site 315750000251 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 315750000252 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 315750000253 dimer interface [polypeptide binding]; other site 315750000254 putative anticodon binding site; other site 315750000255 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 315750000256 motif 1; other site 315750000257 active site 315750000258 motif 2; other site 315750000259 motif 3; other site 315750000260 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 315750000261 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 315750000262 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 315750000263 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 315750000264 ADP binding site [chemical binding]; other site 315750000265 phosphagen binding site; other site 315750000266 substrate specificity loop; other site 315750000267 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 315750000268 Clp amino terminal domain; Region: Clp_N; pfam02861 315750000269 Clp amino terminal domain; Region: Clp_N; pfam02861 315750000270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000271 Walker A motif; other site 315750000272 ATP binding site [chemical binding]; other site 315750000273 Walker B motif; other site 315750000274 arginine finger; other site 315750000275 UvrB/uvrC motif; Region: UVR; pfam02151 315750000276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000277 Walker A motif; other site 315750000278 ATP binding site [chemical binding]; other site 315750000279 Walker B motif; other site 315750000280 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315750000281 DNA repair protein RadA; Provisional; Region: PRK11823 315750000282 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 315750000283 Walker A motif/ATP binding site; other site 315750000284 ATP binding site [chemical binding]; other site 315750000285 Walker B motif; other site 315750000286 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 315750000287 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 315750000288 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315750000289 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 315750000290 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 315750000291 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 315750000292 putative active site [active] 315750000293 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 315750000294 substrate binding site; other site 315750000295 dimer interface; other site 315750000296 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 315750000297 homotrimer interaction site [polypeptide binding]; other site 315750000298 zinc binding site [ion binding]; other site 315750000299 CDP-binding sites; other site 315750000300 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 315750000301 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315750000302 HIGH motif; other site 315750000303 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315750000304 active site 315750000305 KMSKS motif; other site 315750000306 serine O-acetyltransferase; Region: cysE; TIGR01172 315750000307 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 315750000308 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 315750000309 trimer interface [polypeptide binding]; other site 315750000310 active site 315750000311 substrate binding site [chemical binding]; other site 315750000312 CoA binding site [chemical binding]; other site 315750000313 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 315750000314 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 315750000315 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315750000316 active site 315750000317 HIGH motif; other site 315750000318 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315750000319 KMSKS motif; other site 315750000320 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 315750000321 tRNA binding surface [nucleotide binding]; other site 315750000322 anticodon binding site; other site 315750000323 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 315750000324 active site 315750000325 metal binding site [ion binding]; metal-binding site 315750000326 dimerization interface [polypeptide binding]; other site 315750000327 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 315750000328 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 315750000329 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 315750000330 YacP-like NYN domain; Region: NYN_YacP; cl01491 315750000331 RNA polymerase factor sigma-70; Validated; Region: PRK08295 315750000332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750000333 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315750000334 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 315750000335 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 315750000336 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 315750000337 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 315750000338 putative homodimer interface [polypeptide binding]; other site 315750000339 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 315750000340 heterodimer interface [polypeptide binding]; other site 315750000341 homodimer interface [polypeptide binding]; other site 315750000342 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 315750000343 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 315750000344 putative thiostrepton binding site; other site 315750000345 23S rRNA interface [nucleotide binding]; other site 315750000346 L7/L12 interface [polypeptide binding]; other site 315750000347 L25 interface [polypeptide binding]; other site 315750000348 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 315750000349 mRNA/rRNA interface [nucleotide binding]; other site 315750000350 BPUM_nc0001; ribosomal protein L10 leader 315750000351 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 315750000352 23S rRNA interface [nucleotide binding]; other site 315750000353 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 315750000354 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 315750000355 core dimer interface [polypeptide binding]; other site 315750000356 peripheral dimer interface [polypeptide binding]; other site 315750000357 L10 interface [polypeptide binding]; other site 315750000358 L11 interface [polypeptide binding]; other site 315750000359 putative EF-Tu interaction site [polypeptide binding]; other site 315750000360 putative EF-G interaction site [polypeptide binding]; other site 315750000361 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 315750000362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750000363 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 315750000364 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 315750000365 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 315750000366 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 315750000367 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 315750000368 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 315750000369 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 315750000370 RPB10 interaction site [polypeptide binding]; other site 315750000371 RPB1 interaction site [polypeptide binding]; other site 315750000372 RPB11 interaction site [polypeptide binding]; other site 315750000373 RPB3 interaction site [polypeptide binding]; other site 315750000374 RPB12 interaction site [polypeptide binding]; other site 315750000375 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 315750000376 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 315750000377 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 315750000378 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 315750000379 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 315750000380 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 315750000381 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 315750000382 G-loop; other site 315750000383 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 315750000384 DNA binding site [nucleotide binding] 315750000385 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 315750000386 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 315750000387 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 315750000388 S17 interaction site [polypeptide binding]; other site 315750000389 S8 interaction site; other site 315750000390 16S rRNA interaction site [nucleotide binding]; other site 315750000391 streptomycin interaction site [chemical binding]; other site 315750000392 23S rRNA interaction site [nucleotide binding]; other site 315750000393 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 315750000394 30S ribosomal protein S7; Validated; Region: PRK05302 315750000395 elongation factor G; Reviewed; Region: PRK00007 315750000396 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 315750000397 G1 box; other site 315750000398 putative GEF interaction site [polypeptide binding]; other site 315750000399 GTP/Mg2+ binding site [chemical binding]; other site 315750000400 Switch I region; other site 315750000401 G2 box; other site 315750000402 G3 box; other site 315750000403 Switch II region; other site 315750000404 G4 box; other site 315750000405 G5 box; other site 315750000406 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 315750000407 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 315750000408 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 315750000409 elongation factor Tu; Reviewed; Region: PRK00049 315750000410 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 315750000411 G1 box; other site 315750000412 GEF interaction site [polypeptide binding]; other site 315750000413 GTP/Mg2+ binding site [chemical binding]; other site 315750000414 Switch I region; other site 315750000415 G2 box; other site 315750000416 G3 box; other site 315750000417 Switch II region; other site 315750000418 G4 box; other site 315750000419 G5 box; other site 315750000420 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 315750000421 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 315750000422 Antibiotic Binding Site [chemical binding]; other site 315750000423 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315750000424 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 315750000425 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 315750000426 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 315750000427 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 315750000428 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 315750000429 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 315750000430 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 315750000431 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 315750000432 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 315750000433 putative translocon binding site; other site 315750000434 protein-rRNA interface [nucleotide binding]; other site 315750000435 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 315750000436 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 315750000437 G-X-X-G motif; other site 315750000438 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 315750000439 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 315750000440 23S rRNA interface [nucleotide binding]; other site 315750000441 5S rRNA interface [nucleotide binding]; other site 315750000442 putative antibiotic binding site [chemical binding]; other site 315750000443 L25 interface [polypeptide binding]; other site 315750000444 L27 interface [polypeptide binding]; other site 315750000445 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 315750000446 23S rRNA interface [nucleotide binding]; other site 315750000447 putative translocon interaction site; other site 315750000448 signal recognition particle (SRP54) interaction site; other site 315750000449 L23 interface [polypeptide binding]; other site 315750000450 trigger factor interaction site; other site 315750000451 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 315750000452 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 315750000453 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 315750000454 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 315750000455 RNA binding site [nucleotide binding]; other site 315750000456 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 315750000457 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 315750000458 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 315750000459 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 315750000460 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 315750000461 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 315750000462 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315750000463 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315750000464 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 315750000465 5S rRNA interface [nucleotide binding]; other site 315750000466 L27 interface [polypeptide binding]; other site 315750000467 23S rRNA interface [nucleotide binding]; other site 315750000468 L5 interface [polypeptide binding]; other site 315750000469 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 315750000470 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 315750000471 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 315750000472 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 315750000473 23S rRNA binding site [nucleotide binding]; other site 315750000474 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 315750000475 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 315750000476 SecY translocase; Region: SecY; pfam00344 315750000477 adenylate kinase; Reviewed; Region: adk; PRK00279 315750000478 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 315750000479 AMP-binding site [chemical binding]; other site 315750000480 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 315750000481 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315750000482 active site 315750000483 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 315750000484 rRNA binding site [nucleotide binding]; other site 315750000485 predicted 30S ribosome binding site; other site 315750000486 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 315750000487 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 315750000488 30S ribosomal protein S13; Region: bact_S13; TIGR03631 315750000489 30S ribosomal protein S11; Validated; Region: PRK05309 315750000490 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 315750000491 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 315750000492 alphaNTD homodimer interface [polypeptide binding]; other site 315750000493 alphaNTD - beta interaction site [polypeptide binding]; other site 315750000494 alphaNTD - beta' interaction site [polypeptide binding]; other site 315750000495 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 315750000496 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 315750000497 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 315750000498 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315750000499 Walker A/P-loop; other site 315750000500 ATP binding site [chemical binding]; other site 315750000501 Q-loop/lid; other site 315750000502 ABC transporter signature motif; other site 315750000503 Walker B; other site 315750000504 D-loop; other site 315750000505 H-loop/switch region; other site 315750000506 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 315750000507 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315750000508 Walker A/P-loop; other site 315750000509 ATP binding site [chemical binding]; other site 315750000510 Q-loop/lid; other site 315750000511 ABC transporter signature motif; other site 315750000512 Walker B; other site 315750000513 D-loop; other site 315750000514 H-loop/switch region; other site 315750000515 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 315750000516 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 315750000517 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 315750000518 dimerization interface 3.5A [polypeptide binding]; other site 315750000519 active site 315750000520 BPUM_nc0002; ribosomal protein L13 leader 315750000521 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 315750000522 23S rRNA interface [nucleotide binding]; other site 315750000523 L3 interface [polypeptide binding]; other site 315750000524 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 315750000525 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750000526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750000527 Coenzyme A binding pocket [chemical binding]; other site 315750000528 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 315750000529 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750000530 active site 315750000531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750000532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750000533 Coenzyme A binding pocket [chemical binding]; other site 315750000534 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 315750000535 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 315750000536 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315750000537 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750000538 active site 315750000539 metal binding site [ion binding]; metal-binding site 315750000540 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 315750000541 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 315750000542 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 315750000543 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750000544 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750000545 flagellin; Provisional; Region: PRK12804 315750000546 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750000547 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750000548 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315750000549 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 315750000550 Sulfate transporter family; Region: Sulfate_transp; pfam00916 315750000551 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315750000552 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 315750000553 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 315750000554 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 315750000555 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 315750000556 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 315750000557 putative periplasmic esterase; Provisional; Region: PRK03642 315750000558 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315750000559 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 315750000560 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750000561 active site turn [active] 315750000562 phosphorylation site [posttranslational modification] 315750000563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750000564 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750000565 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750000566 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750000567 putative active site [active] 315750000568 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 315750000569 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 315750000570 putative active site [active] 315750000571 agmatinase; Region: agmatinase; TIGR01230 315750000572 Arginase family; Region: Arginase; cd09989 315750000573 active site 315750000574 Mn binding site [ion binding]; other site 315750000575 oligomer interface [polypeptide binding]; other site 315750000576 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 315750000577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750000578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750000579 DNA binding residues [nucleotide binding] 315750000580 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 315750000581 Putative zinc-finger; Region: zf-HC2; pfam13490 315750000582 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 315750000583 Uncharacterized conserved protein [Function unknown]; Region: COG1624 315750000584 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315750000585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 315750000586 YbbR-like protein; Region: YbbR; pfam07949 315750000587 YbbR-like protein; Region: YbbR; pfam07949 315750000588 YbbR-like protein; Region: YbbR; pfam07949 315750000589 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 315750000590 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 315750000591 active site 315750000592 substrate binding site [chemical binding]; other site 315750000593 metal binding site [ion binding]; metal-binding site 315750000594 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 315750000595 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 315750000596 glutaminase active site [active] 315750000597 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 315750000598 dimer interface [polypeptide binding]; other site 315750000599 active site 315750000600 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 315750000601 dimer interface [polypeptide binding]; other site 315750000602 active site 315750000603 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 315750000604 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 315750000605 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750000606 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750000607 Walker A/P-loop; other site 315750000608 ATP binding site [chemical binding]; other site 315750000609 Q-loop/lid; other site 315750000610 ABC transporter signature motif; other site 315750000611 Walker B; other site 315750000612 D-loop; other site 315750000613 H-loop/switch region; other site 315750000614 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 315750000615 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 315750000616 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750000617 homotrimer interaction site [polypeptide binding]; other site 315750000618 putative active site [active] 315750000619 Predicted membrane protein [Function unknown]; Region: COG2311 315750000620 Protein of unknown function (DUF418); Region: DUF418; pfam04235 315750000621 Predicted transcriptional regulators [Transcription]; Region: COG1725 315750000622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750000623 DNA-binding site [nucleotide binding]; DNA binding site 315750000624 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750000625 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750000626 Walker A/P-loop; other site 315750000627 ATP binding site [chemical binding]; other site 315750000628 Q-loop/lid; other site 315750000629 ABC transporter signature motif; other site 315750000630 Walker B; other site 315750000631 D-loop; other site 315750000632 H-loop/switch region; other site 315750000633 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315750000634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750000635 non-specific DNA binding site [nucleotide binding]; other site 315750000636 salt bridge; other site 315750000637 sequence-specific DNA binding site [nucleotide binding]; other site 315750000638 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750000639 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750000640 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315750000641 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 315750000642 active site 315750000643 catalytic site [active] 315750000644 metal binding site [ion binding]; metal-binding site 315750000645 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 315750000646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000647 putative substrate translocation pore; other site 315750000648 SurA N-terminal domain; Region: SurA_N; pfam09312 315750000649 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 315750000650 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 315750000651 catalytic residues [active] 315750000652 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 315750000653 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 315750000654 putative homodimer interface [polypeptide binding]; other site 315750000655 putative homotetramer interface [polypeptide binding]; other site 315750000656 putative metal binding site [ion binding]; other site 315750000657 putative homodimer-homodimer interface [polypeptide binding]; other site 315750000658 putative allosteric switch controlling residues; other site 315750000659 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 315750000660 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750000661 active site residue [active] 315750000662 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315750000663 CPxP motif; other site 315750000664 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750000665 active site residue [active] 315750000666 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 315750000667 active site residue [active] 315750000668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315750000669 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315750000670 CPxP motif; other site 315750000671 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315750000672 prolyl-tRNA synthetase; Provisional; Region: PRK08661 315750000673 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 315750000674 dimer interface [polypeptide binding]; other site 315750000675 motif 1; other site 315750000676 active site 315750000677 motif 2; other site 315750000678 motif 3; other site 315750000679 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 315750000680 anticodon binding site; other site 315750000681 zinc-binding site [ion binding]; other site 315750000682 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750000683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000684 putative substrate translocation pore; other site 315750000685 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 315750000686 Coenzyme A binding pocket [chemical binding]; other site 315750000687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750000688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750000689 putative DNA binding site [nucleotide binding]; other site 315750000690 dimerization interface [polypeptide binding]; other site 315750000691 putative Zn2+ binding site [ion binding]; other site 315750000692 Uncharacterized conserved protein [Function unknown]; Region: COG1683 315750000693 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750000694 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750000695 active site 315750000696 catalytic tetrad [active] 315750000697 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 315750000698 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 315750000699 putative active site [active] 315750000700 metal binding site [ion binding]; metal-binding site 315750000701 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 315750000702 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 315750000703 active site residue [active] 315750000704 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 315750000705 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 315750000706 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750000707 CAT RNA binding domain; Region: CAT_RBD; smart01061 315750000708 PRD domain; Region: PRD; pfam00874 315750000709 PRD domain; Region: PRD; pfam00874 315750000710 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750000711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750000712 active site turn [active] 315750000713 phosphorylation site [posttranslational modification] 315750000714 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750000715 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 315750000716 HPr interaction site; other site 315750000717 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750000718 active site 315750000719 phosphorylation site [posttranslational modification] 315750000720 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 315750000721 beta-galactosidase; Region: BGL; TIGR03356 315750000722 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 315750000723 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750000724 HTH domain; Region: HTH_11; pfam08279 315750000725 Mga helix-turn-helix domain; Region: Mga; pfam05043 315750000726 PRD domain; Region: PRD; pfam00874 315750000727 PRD domain; Region: PRD; pfam00874 315750000728 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750000729 active site 315750000730 P-loop; other site 315750000731 phosphorylation site [posttranslational modification] 315750000732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750000733 active site 315750000734 phosphorylation site [posttranslational modification] 315750000735 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750000736 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750000737 nucleotide binding site [chemical binding]; other site 315750000738 alpha-mannosidase; Provisional; Region: PRK09819 315750000739 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 315750000740 active site 315750000741 metal binding site [ion binding]; metal-binding site 315750000742 catalytic site [active] 315750000743 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 315750000744 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 315750000745 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315750000746 active site 315750000747 P-loop; other site 315750000748 phosphorylation site [posttranslational modification] 315750000749 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750000750 active site 315750000751 phosphorylation site [posttranslational modification] 315750000752 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 315750000753 active site 315750000754 catalytic triad [active] 315750000755 MG2 domain; Region: A2M_N; pfam01835 315750000756 S-methylmethionine transporter; Provisional; Region: PRK11387 315750000757 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 315750000758 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 315750000759 Predicted transcriptional regulators [Transcription]; Region: COG1695 315750000760 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315750000761 Predicted membrane protein [Function unknown]; Region: COG4709 315750000762 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 315750000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000764 putative substrate translocation pore; other site 315750000765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750000766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750000767 Coenzyme A binding pocket [chemical binding]; other site 315750000768 Protein of unknown function (DUF402); Region: DUF402; pfam04167 315750000769 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315750000770 active site 315750000771 catalytic residues [active] 315750000772 amidase; Provisional; Region: PRK06529 315750000773 Amidase; Region: Amidase; pfam01425 315750000774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750000776 Cupin domain; Region: Cupin_2; pfam07883 315750000777 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 315750000778 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 315750000779 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315750000780 NAD binding site [chemical binding]; other site 315750000781 catalytic Zn binding site [ion binding]; other site 315750000782 structural Zn binding site [ion binding]; other site 315750000783 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750000784 MarR family; Region: MarR; pfam01047 315750000785 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315750000786 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315750000787 acyl-activating enzyme (AAE) consensus motif; other site 315750000788 AMP binding site [chemical binding]; other site 315750000789 active site 315750000790 CoA binding site [chemical binding]; other site 315750000791 amino acid transporter; Region: 2A0306; TIGR00909 315750000792 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 315750000793 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315750000794 dimer interface [polypeptide binding]; other site 315750000795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750000796 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315750000797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315750000798 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315750000799 amino acid carrier protein; Region: agcS; TIGR00835 315750000800 glutaminase; Reviewed; Region: PRK12357 315750000801 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 315750000802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750000803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750000804 ATP binding site [chemical binding]; other site 315750000805 Mg2+ binding site [ion binding]; other site 315750000806 G-X-G motif; other site 315750000807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750000808 Response regulator receiver domain; Region: Response_reg; pfam00072 315750000809 active site 315750000810 phosphorylation site [posttranslational modification] 315750000811 intermolecular recognition site; other site 315750000812 dimerization interface [polypeptide binding]; other site 315750000813 YcbB domain; Region: YcbB; pfam08664 315750000814 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 315750000815 SEC-C motif; Region: SEC-C; pfam02810 315750000816 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 315750000817 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315750000818 putative DNA binding site [nucleotide binding]; other site 315750000819 putative Zn2+ binding site [ion binding]; other site 315750000820 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 315750000821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750000822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750000823 active site 315750000824 catalytic tetrad [active] 315750000825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750000826 ATP binding site [chemical binding]; other site 315750000827 Mg2+ binding site [ion binding]; other site 315750000828 G-X-G motif; other site 315750000829 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 315750000830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750000831 active site 315750000832 phosphorylation site [posttranslational modification] 315750000833 intermolecular recognition site; other site 315750000834 dimerization interface [polypeptide binding]; other site 315750000835 LytTr DNA-binding domain; Region: LytTR; smart00850 315750000836 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750000837 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 315750000838 Walker A/P-loop; other site 315750000839 ATP binding site [chemical binding]; other site 315750000840 Q-loop/lid; other site 315750000841 ABC transporter signature motif; other site 315750000842 Walker B; other site 315750000843 D-loop; other site 315750000844 H-loop/switch region; other site 315750000845 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315750000846 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 315750000847 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 315750000848 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 315750000849 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315750000850 glucose-1-dehydrogenase; Provisional; Region: PRK08936 315750000851 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 315750000852 NAD binding site [chemical binding]; other site 315750000853 homodimer interface [polypeptide binding]; other site 315750000854 active site 315750000855 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 315750000856 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750000857 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 315750000858 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 315750000859 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750000860 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750000861 putative metal binding site [ion binding]; other site 315750000862 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750000863 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750000864 putative metal binding site [ion binding]; other site 315750000865 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750000866 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750000867 putative metal binding site [ion binding]; other site 315750000868 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 315750000869 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 315750000870 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 315750000871 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 315750000872 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 315750000873 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 315750000874 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315750000875 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 315750000876 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 315750000877 Walker A/P-loop; other site 315750000878 ATP binding site [chemical binding]; other site 315750000879 Q-loop/lid; other site 315750000880 ABC transporter signature motif; other site 315750000881 Walker B; other site 315750000882 D-loop; other site 315750000883 H-loop/switch region; other site 315750000884 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 315750000885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750000886 dimer interface [polypeptide binding]; other site 315750000887 conserved gate region; other site 315750000888 putative PBP binding loops; other site 315750000889 ABC-ATPase subunit interface; other site 315750000890 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 315750000891 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315750000892 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315750000893 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750000894 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 315750000895 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 315750000896 classical (c) SDRs; Region: SDR_c; cd05233 315750000897 NAD(P) binding site [chemical binding]; other site 315750000898 active site 315750000899 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 315750000900 amidohydrolase; Region: amidohydrolases; TIGR01891 315750000901 metal binding site [ion binding]; metal-binding site 315750000902 putative dimer interface [polypeptide binding]; other site 315750000903 Predicted membrane protein [Function unknown]; Region: COG1288 315750000904 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 315750000905 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315750000906 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315750000907 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750000908 NAD binding site [chemical binding]; other site 315750000909 dimer interface [polypeptide binding]; other site 315750000910 substrate binding site [chemical binding]; other site 315750000911 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 315750000912 L-lactate permease; Region: Lactate_perm; pfam02652 315750000913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750000914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750000915 DNA binding site [nucleotide binding] 315750000916 domain linker motif; other site 315750000917 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315750000918 putative dimerization interface [polypeptide binding]; other site 315750000919 putative ligand binding site [chemical binding]; other site 315750000920 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 315750000921 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750000922 inhibitor-cofactor binding pocket; inhibition site 315750000923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000924 catalytic residue [active] 315750000925 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 315750000926 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315750000927 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315750000928 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315750000929 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 315750000930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000931 putative substrate translocation pore; other site 315750000932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750000933 LysE type translocator; Region: LysE; pfam01810 315750000934 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 315750000935 Spore germination protein; Region: Spore_permease; cl17796 315750000936 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750000937 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 315750000938 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 315750000939 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 315750000940 homodimer interface [polypeptide binding]; other site 315750000941 NAD binding pocket [chemical binding]; other site 315750000942 ATP binding pocket [chemical binding]; other site 315750000943 Mg binding site [ion binding]; other site 315750000944 active-site loop [active] 315750000945 shikimate kinase; Reviewed; Region: aroK; PRK00131 315750000946 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 315750000947 ADP binding site [chemical binding]; other site 315750000948 magnesium binding site [ion binding]; other site 315750000949 putative shikimate binding site; other site 315750000950 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 315750000951 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 315750000952 inhibitor site; inhibition site 315750000953 active site 315750000954 dimer interface [polypeptide binding]; other site 315750000955 catalytic residue [active] 315750000956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750000957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750000958 DNA binding site [nucleotide binding] 315750000959 domain linker motif; other site 315750000960 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 315750000961 dimerization interface [polypeptide binding]; other site 315750000962 ligand binding site [chemical binding]; other site 315750000963 benzoate transport; Region: 2A0115; TIGR00895 315750000964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750000967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750000968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750000969 dimerization interface [polypeptide binding]; other site 315750000970 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315750000971 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 315750000972 putative active site [active] 315750000973 catalytic triad [active] 315750000974 putative dimer interface [polypeptide binding]; other site 315750000975 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 315750000976 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 315750000977 Proline dehydrogenase; Region: Pro_dh; cl03282 315750000978 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 315750000979 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 315750000980 Glutamate binding site [chemical binding]; other site 315750000981 homodimer interface [polypeptide binding]; other site 315750000982 NAD binding site [chemical binding]; other site 315750000983 catalytic residues [active] 315750000984 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315750000985 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750000986 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 315750000987 arsenical pump membrane protein; Provisional; Region: PRK15445 315750000988 transmembrane helices; other site 315750000989 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750000991 dimer interface [polypeptide binding]; other site 315750000992 conserved gate region; other site 315750000993 putative PBP binding loops; other site 315750000994 ABC-ATPase subunit interface; other site 315750000995 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750000996 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750000997 substrate binding pocket [chemical binding]; other site 315750000998 membrane-bound complex binding site; other site 315750000999 hinge residues; other site 315750001000 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 315750001001 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 315750001002 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 315750001003 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 315750001004 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 315750001005 AsnC family; Region: AsnC_trans_reg; pfam01037 315750001006 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 315750001007 Competence protein J (ComJ); Region: ComJ; pfam11033 315750001008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750001009 dimerization interface [polypeptide binding]; other site 315750001010 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750001011 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750001012 dimer interface [polypeptide binding]; other site 315750001013 putative CheW interface [polypeptide binding]; other site 315750001014 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 315750001015 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 315750001016 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 315750001017 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 315750001018 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 315750001019 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 315750001020 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 315750001021 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 315750001022 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 315750001023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750001024 Walker A/P-loop; other site 315750001025 ATP binding site [chemical binding]; other site 315750001026 Q-loop/lid; other site 315750001027 ABC transporter signature motif; other site 315750001028 Walker B; other site 315750001029 D-loop; other site 315750001030 H-loop/switch region; other site 315750001031 TOBE domain; Region: TOBE_2; pfam08402 315750001032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750001033 dimer interface [polypeptide binding]; other site 315750001034 conserved gate region; other site 315750001035 putative PBP binding loops; other site 315750001036 ABC-ATPase subunit interface; other site 315750001037 Condensation domain; Region: Condensation; pfam00668 315750001038 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001039 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001040 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315750001041 acyl-activating enzyme (AAE) consensus motif; other site 315750001042 AMP binding site [chemical binding]; other site 315750001043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001044 Condensation domain; Region: Condensation; pfam00668 315750001045 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001046 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001047 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 315750001048 acyl-activating enzyme (AAE) consensus motif; other site 315750001049 AMP binding site [chemical binding]; other site 315750001050 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001051 Condensation domain; Region: Condensation; pfam00668 315750001052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001053 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001054 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315750001055 acyl-activating enzyme (AAE) consensus motif; other site 315750001056 AMP binding site [chemical binding]; other site 315750001057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001058 Condensation domain; Region: Condensation; pfam00668 315750001059 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001060 Condensation domain; Region: Condensation; pfam00668 315750001061 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001062 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 315750001063 acyl-activating enzyme (AAE) consensus motif; other site 315750001064 AMP binding site [chemical binding]; other site 315750001065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001066 Condensation domain; Region: Condensation; pfam00668 315750001067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001068 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001069 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315750001070 acyl-activating enzyme (AAE) consensus motif; other site 315750001071 AMP binding site [chemical binding]; other site 315750001072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001073 Condensation domain; Region: Condensation; pfam00668 315750001074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001075 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001076 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315750001077 acyl-activating enzyme (AAE) consensus motif; other site 315750001078 AMP binding site [chemical binding]; other site 315750001079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001080 Condensation domain; Region: Condensation; pfam00668 315750001081 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001082 Condensation domain; Region: Condensation; pfam00668 315750001083 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001084 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 315750001085 acyl-activating enzyme (AAE) consensus motif; other site 315750001086 AMP binding site [chemical binding]; other site 315750001087 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001088 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 315750001089 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 315750001090 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 315750001091 acyl-activating enzyme (AAE) consensus motif; other site 315750001092 putative AMP binding site [chemical binding]; other site 315750001093 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750001094 KR domain; Region: KR; pfam08659 315750001095 putative NADP binding site [chemical binding]; other site 315750001096 active site 315750001097 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001098 Condensation domain; Region: Condensation; pfam00668 315750001099 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001100 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001101 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 315750001102 acyl-activating enzyme (AAE) consensus motif; other site 315750001103 AMP binding site [chemical binding]; other site 315750001104 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001105 Condensation domain; Region: Condensation; pfam00668 315750001106 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001107 Condensation domain; Region: Condensation; pfam00668 315750001108 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001109 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315750001110 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 315750001111 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 315750001112 acyl-activating enzyme (AAE) consensus motif; other site 315750001113 putative AMP binding site [chemical binding]; other site 315750001114 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750001115 putative NADP binding site [chemical binding]; other site 315750001116 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 315750001117 active site 315750001118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001119 Condensation domain; Region: Condensation; pfam00668 315750001120 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001121 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001122 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 315750001123 acyl-activating enzyme (AAE) consensus motif; other site 315750001124 AMP binding site [chemical binding]; other site 315750001125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001126 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 315750001127 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 315750001128 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315750001129 EamA-like transporter family; Region: EamA; pfam00892 315750001130 EamA-like transporter family; Region: EamA; pfam00892 315750001131 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750001132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001133 DNA-binding site [nucleotide binding]; DNA binding site 315750001134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750001135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001136 homodimer interface [polypeptide binding]; other site 315750001137 catalytic residue [active] 315750001138 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 315750001139 Predicted membrane protein [Function unknown]; Region: COG2364 315750001140 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750001141 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315750001142 active site 315750001143 catalytic site [active] 315750001144 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315750001145 FtsX-like permease family; Region: FtsX; pfam02687 315750001146 FtsX-like permease family; Region: FtsX; pfam02687 315750001147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750001148 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315750001149 Walker A/P-loop; other site 315750001150 ATP binding site [chemical binding]; other site 315750001151 Q-loop/lid; other site 315750001152 ABC transporter signature motif; other site 315750001153 Walker B; other site 315750001154 D-loop; other site 315750001155 H-loop/switch region; other site 315750001156 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750001157 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750001158 Walker A/P-loop; other site 315750001159 ATP binding site [chemical binding]; other site 315750001160 Q-loop/lid; other site 315750001161 ABC transporter signature motif; other site 315750001162 Walker B; other site 315750001163 D-loop; other site 315750001164 H-loop/switch region; other site 315750001165 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750001166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750001167 dimer interface [polypeptide binding]; other site 315750001168 conserved gate region; other site 315750001169 putative PBP binding loops; other site 315750001170 ABC-ATPase subunit interface; other site 315750001171 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750001172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750001173 substrate binding pocket [chemical binding]; other site 315750001174 membrane-bound complex binding site; other site 315750001175 hinge residues; other site 315750001176 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 315750001177 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315750001178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001179 putative substrate translocation pore; other site 315750001180 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 315750001181 Right handed beta helix region; Region: Beta_helix; pfam13229 315750001182 Right handed beta helix region; Region: Beta_helix; pfam13229 315750001183 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 315750001184 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 315750001185 active site 315750001186 non-prolyl cis peptide bond; other site 315750001187 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750001188 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750001189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750001190 substrate binding pocket [chemical binding]; other site 315750001191 membrane-bound complex binding site; other site 315750001192 hinge residues; other site 315750001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750001194 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750001195 dimer interface [polypeptide binding]; other site 315750001196 conserved gate region; other site 315750001197 putative PBP binding loops; other site 315750001198 ABC-ATPase subunit interface; other site 315750001199 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750001200 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750001201 Walker A/P-loop; other site 315750001202 ATP binding site [chemical binding]; other site 315750001203 Q-loop/lid; other site 315750001204 ABC transporter signature motif; other site 315750001205 Walker B; other site 315750001206 D-loop; other site 315750001207 H-loop/switch region; other site 315750001208 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315750001209 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 315750001210 metal binding site [ion binding]; metal-binding site 315750001211 dimer interface [polypeptide binding]; other site 315750001212 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 315750001213 Transposase domain (DUF772); Region: DUF772; pfam05598 315750001214 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750001215 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750001216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750001217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750001218 active site 315750001219 phosphorylation site [posttranslational modification] 315750001220 intermolecular recognition site; other site 315750001221 dimerization interface [polypeptide binding]; other site 315750001222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750001223 DNA binding site [nucleotide binding] 315750001224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750001225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750001226 dimerization interface [polypeptide binding]; other site 315750001227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750001228 dimer interface [polypeptide binding]; other site 315750001229 phosphorylation site [posttranslational modification] 315750001230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001231 ATP binding site [chemical binding]; other site 315750001232 Mg2+ binding site [ion binding]; other site 315750001233 G-X-G motif; other site 315750001234 GAF domain; Region: GAF; pfam01590 315750001235 GAF domain; Region: GAF_2; pfam13185 315750001236 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750001237 aspartate kinase; Reviewed; Region: PRK09034 315750001238 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 315750001239 putative catalytic residues [active] 315750001240 putative nucleotide binding site [chemical binding]; other site 315750001241 putative aspartate binding site [chemical binding]; other site 315750001242 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 315750001243 allosteric regulatory residue; other site 315750001244 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 315750001245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001246 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315750001247 putative substrate translocation pore; other site 315750001248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750001251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750001252 dimerization interface [polypeptide binding]; other site 315750001253 putative DNA binding site [nucleotide binding]; other site 315750001254 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750001255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001256 DNA-binding site [nucleotide binding]; DNA binding site 315750001257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750001258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001259 homodimer interface [polypeptide binding]; other site 315750001260 catalytic residue [active] 315750001261 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 315750001262 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750001263 inhibitor-cofactor binding pocket; inhibition site 315750001264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001265 catalytic residue [active] 315750001266 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 315750001267 succinic semialdehyde dehydrogenase; Region: PLN02278 315750001268 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 315750001269 tetramerization interface [polypeptide binding]; other site 315750001270 NAD(P) binding site [chemical binding]; other site 315750001271 catalytic residues [active] 315750001272 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 315750001273 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 315750001274 CopC domain; Region: CopC; pfam04234 315750001275 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 315750001276 YtkA-like; Region: YtkA; pfam13115 315750001277 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 315750001278 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 315750001279 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 315750001280 active site 315750001281 P-loop; other site 315750001282 phosphorylation site [posttranslational modification] 315750001283 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750001284 active site 315750001285 phosphorylation site [posttranslational modification] 315750001286 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 315750001287 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 315750001288 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 315750001289 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 315750001290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750001291 dimerization interface [polypeptide binding]; other site 315750001292 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750001293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750001294 dimer interface [polypeptide binding]; other site 315750001295 putative CheW interface [polypeptide binding]; other site 315750001296 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750001297 homotrimer interaction site [polypeptide binding]; other site 315750001298 putative active site [active] 315750001299 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750001300 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315750001301 active site 315750001302 metal binding site [ion binding]; metal-binding site 315750001303 Excalibur calcium-binding domain; Region: Excalibur; smart00894 315750001304 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 315750001305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750001306 active site 315750001307 motif I; other site 315750001308 motif II; other site 315750001309 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315750001310 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 315750001311 putative active site [active] 315750001312 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 315750001313 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 315750001314 hypothetical protein; Provisional; Region: PRK05463 315750001315 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 315750001316 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 315750001317 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 315750001318 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 315750001319 Transcriptional regulator [Transcription]; Region: IclR; COG1414 315750001320 Bacterial transcriptional regulator; Region: IclR; pfam01614 315750001321 azoreductase; Reviewed; Region: PRK00170 315750001322 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750001323 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315750001324 active site 315750001325 catalytic triad [active] 315750001326 oxyanion hole [active] 315750001327 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 315750001328 active site 315750001329 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 315750001330 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750001331 HTH domain; Region: HTH_11; pfam08279 315750001332 HTH domain; Region: HTH_11; pfam08279 315750001333 PRD domain; Region: PRD; pfam00874 315750001334 PRD domain; Region: PRD; pfam00874 315750001335 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750001336 active site 315750001337 P-loop; other site 315750001338 phosphorylation site [posttranslational modification] 315750001339 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315750001340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750001341 S-adenosylmethionine binding site [chemical binding]; other site 315750001342 short chain dehydrogenase; Provisional; Region: PRK06701 315750001343 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 315750001344 NAD binding site [chemical binding]; other site 315750001345 metal binding site [ion binding]; metal-binding site 315750001346 active site 315750001347 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 315750001348 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 315750001349 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 315750001350 Transcriptional regulators [Transcription]; Region: GntR; COG1802 315750001351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001352 DNA-binding site [nucleotide binding]; DNA binding site 315750001353 FCD domain; Region: FCD; pfam07729 315750001354 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 315750001355 tartrate dehydrogenase; Provisional; Region: PRK08194 315750001356 DNA topoisomerase III; Provisional; Region: PRK07726 315750001357 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315750001358 active site 315750001359 putative interdomain interaction site [polypeptide binding]; other site 315750001360 putative metal-binding site [ion binding]; other site 315750001361 putative nucleotide binding site [chemical binding]; other site 315750001362 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315750001363 domain I; other site 315750001364 DNA binding groove [nucleotide binding] 315750001365 phosphate binding site [ion binding]; other site 315750001366 domain II; other site 315750001367 domain III; other site 315750001368 nucleotide binding site [chemical binding]; other site 315750001369 catalytic site [active] 315750001370 domain IV; other site 315750001371 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 315750001372 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 315750001373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315750001374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750001375 metal binding site [ion binding]; metal-binding site 315750001376 active site 315750001377 I-site; other site 315750001378 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750001379 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 315750001380 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 315750001381 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 315750001382 DXD motif; other site 315750001383 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 315750001384 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 315750001385 possible YdaO-YuaA riboswitch; BPUM_nc0004 315750001386 Amino acid permease; Region: AA_permease_2; pfam13520 315750001387 pyruvate oxidase; Provisional; Region: PRK08611 315750001388 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 315750001389 PYR/PP interface [polypeptide binding]; other site 315750001390 dimer interface [polypeptide binding]; other site 315750001391 tetramer interface [polypeptide binding]; other site 315750001392 TPP binding site [chemical binding]; other site 315750001393 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315750001394 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 315750001395 TPP-binding site [chemical binding]; other site 315750001396 LXG domain of WXG superfamily; Region: LXG; pfam04740 315750001397 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750001398 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004 315750001399 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750001400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750001401 Coenzyme A binding pocket [chemical binding]; other site 315750001402 manganese transport protein MntH; Reviewed; Region: PRK00701 315750001403 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 315750001404 Predicted membrane protein [Function unknown]; Region: COG2261 315750001405 EcsC protein family; Region: EcsC; pfam12787 315750001406 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 315750001407 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 315750001408 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315750001409 PAS domain; Region: PAS; smart00091 315750001410 putative active site [active] 315750001411 heme pocket [chemical binding]; other site 315750001412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001413 ATP binding site [chemical binding]; other site 315750001414 Mg2+ binding site [ion binding]; other site 315750001415 G-X-G motif; other site 315750001416 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315750001417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750001418 active site 315750001419 phosphorylation site [posttranslational modification] 315750001420 intermolecular recognition site; other site 315750001421 dimerization interface [polypeptide binding]; other site 315750001422 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 315750001423 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 315750001424 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750001425 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315750001426 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750001427 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750001428 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 315750001429 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750001430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750001431 Walker A/P-loop; other site 315750001432 ATP binding site [chemical binding]; other site 315750001433 Q-loop/lid; other site 315750001434 ABC transporter signature motif; other site 315750001435 Walker B; other site 315750001436 D-loop; other site 315750001437 H-loop/switch region; other site 315750001438 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 315750001439 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315750001440 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 315750001441 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750001442 catalytic residues [active] 315750001443 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 315750001444 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 315750001445 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 315750001446 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 315750001447 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315750001448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750001449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750001450 Esterase/lipase [General function prediction only]; Region: COG1647 315750001451 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 315750001452 iron-sulfur cluster [ion binding]; other site 315750001453 [2Fe-2S] cluster binding site [ion binding]; other site 315750001454 helicase 45; Provisional; Region: PTZ00424 315750001455 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750001456 ATP binding site [chemical binding]; other site 315750001457 Mg++ binding site [ion binding]; other site 315750001458 motif III; other site 315750001459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750001460 nucleotide binding region [chemical binding]; other site 315750001461 ATP-binding site [chemical binding]; other site 315750001462 Uncharacterized conserved protein [Function unknown]; Region: COG3402 315750001463 Predicted membrane protein [Function unknown]; Region: COG3428 315750001464 Bacterial PH domain; Region: DUF304; pfam03703 315750001465 Bacterial PH domain; Region: DUF304; pfam03703 315750001466 Bacterial PH domain; Region: DUF304; pfam03703 315750001467 Rhomboid family; Region: Rhomboid; pfam01694 315750001468 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 315750001469 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 315750001470 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 315750001471 alanine racemase; Region: alr; TIGR00492 315750001472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315750001473 active site 315750001474 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750001475 dimer interface [polypeptide binding]; other site 315750001476 substrate binding site [chemical binding]; other site 315750001477 catalytic residues [active] 315750001478 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 315750001479 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 315750001480 Rsbr N terminal; Region: Rsbr_N; pfam08678 315750001481 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750001482 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750001483 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315750001484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001485 ATP binding site [chemical binding]; other site 315750001486 Mg2+ binding site [ion binding]; other site 315750001487 G-X-G motif; other site 315750001488 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 315750001489 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 315750001490 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 315750001491 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 315750001492 anti sigma factor interaction site; other site 315750001493 regulatory phosphorylation site [posttranslational modification]; other site 315750001494 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315750001495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001496 ATP binding site [chemical binding]; other site 315750001497 Mg2+ binding site [ion binding]; other site 315750001498 G-X-G motif; other site 315750001499 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 315750001500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750001501 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750001502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750001503 DNA binding residues [nucleotide binding] 315750001504 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 315750001505 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 315750001506 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 315750001507 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 315750001508 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 315750001509 RNA binding site [nucleotide binding]; other site 315750001510 hypothetical protein; Provisional; Region: PRK04351 315750001511 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 315750001512 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 315750001513 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750001514 tetramer interface [polypeptide binding]; other site 315750001515 TPP-binding site [chemical binding]; other site 315750001516 heterodimer interface [polypeptide binding]; other site 315750001517 phosphorylation loop region [posttranslational modification] 315750001518 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750001519 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750001520 alpha subunit interface [polypeptide binding]; other site 315750001521 TPP binding site [chemical binding]; other site 315750001522 heterodimer interface [polypeptide binding]; other site 315750001523 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750001524 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750001525 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750001526 E3 interaction surface; other site 315750001527 lipoyl attachment site [posttranslational modification]; other site 315750001528 e3 binding domain; Region: E3_binding; pfam02817 315750001529 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315750001530 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 315750001531 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 315750001532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750001533 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750001534 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 315750001535 GAF domain; Region: GAF; pfam01590 315750001536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750001537 Walker A motif; other site 315750001538 ATP binding site [chemical binding]; other site 315750001539 Walker B motif; other site 315750001540 arginine finger; other site 315750001541 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315750001542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750001543 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315750001544 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315750001545 DNA-binding site [nucleotide binding]; DNA binding site 315750001546 RNA-binding motif; other site 315750001547 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 315750001548 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 315750001549 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 315750001550 putative NAD(P) binding site [chemical binding]; other site 315750001551 putative substrate binding site [chemical binding]; other site 315750001552 catalytic Zn binding site [ion binding]; other site 315750001553 structural Zn binding site [ion binding]; other site 315750001554 dimer interface [polypeptide binding]; other site 315750001555 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315750001556 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 315750001557 DNA binding residues [nucleotide binding] 315750001558 putative dimer interface [polypeptide binding]; other site 315750001559 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 315750001560 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 315750001561 active site 315750001562 active site 315750001563 catalytic residues [active] 315750001564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750001566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001567 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315750001568 putative substrate translocation pore; other site 315750001569 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 315750001570 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315750001571 substrate binding pocket [chemical binding]; other site 315750001572 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315750001573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 315750001574 classical (c) SDRs; Region: SDR_c; cd05233 315750001575 NAD(P) binding site [chemical binding]; other site 315750001576 active site 315750001577 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 315750001578 active site 315750001579 homotetramer interface [polypeptide binding]; other site 315750001580 homodimer interface [polypeptide binding]; other site 315750001581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315750001582 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 315750001583 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315750001584 MarR family; Region: MarR_2; pfam12802 315750001585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750001587 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 315750001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750001590 putative substrate translocation pore; other site 315750001591 Protein of unknown function (DUF627); Region: DUF627; pfam04781 315750001592 LytTr DNA-binding domain; Region: LytTR; smart00850 315750001593 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 315750001594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750001595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750001596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001597 Coenzyme A binding pocket [chemical binding]; other site 315750001598 YesK-like protein; Region: YesK; pfam14150 315750001599 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750001600 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750001601 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 315750001602 dimer interface [polypeptide binding]; other site 315750001603 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750001604 metal binding site [ion binding]; metal-binding site 315750001605 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750001606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001607 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315750001608 RibD C-terminal domain; Region: RibD_C; cl17279 315750001609 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 315750001610 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750001611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750001612 putative DNA binding site [nucleotide binding]; other site 315750001613 putative Zn2+ binding site [ion binding]; other site 315750001614 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315750001615 dimer interface [polypeptide binding]; other site 315750001616 FMN binding site [chemical binding]; other site 315750001617 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 315750001618 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 315750001619 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315750001620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750001621 non-specific DNA binding site [nucleotide binding]; other site 315750001622 salt bridge; other site 315750001623 sequence-specific DNA binding site [nucleotide binding]; other site 315750001624 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 315750001625 Cupin domain; Region: Cupin_2; pfam07883 315750001626 LysE type translocator; Region: LysE; cl00565 315750001627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315750001628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001629 Coenzyme A binding pocket [chemical binding]; other site 315750001630 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 315750001631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750001632 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 315750001633 dimerization interface [polypeptide binding]; other site 315750001634 substrate binding pocket [chemical binding]; other site 315750001635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750001636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750001637 active site 315750001638 catalytic tetrad [active] 315750001639 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315750001640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750001641 S-adenosylmethionine binding site [chemical binding]; other site 315750001642 Predicted membrane protein [Function unknown]; Region: COG4392 315750001643 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 315750001644 EamA-like transporter family; Region: EamA; pfam00892 315750001645 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315750001646 EamA-like transporter family; Region: EamA; pfam00892 315750001647 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750001648 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750001649 YaaC-like Protein; Region: YaaC; pfam14175 315750001650 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 315750001651 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 315750001652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 315750001653 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 315750001654 active site 315750001655 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315750001656 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315750001657 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 315750001658 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750001659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001660 DNA-binding site [nucleotide binding]; DNA binding site 315750001661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750001662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001663 homodimer interface [polypeptide binding]; other site 315750001664 catalytic residue [active] 315750001665 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 315750001666 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 315750001667 active site 315750001668 multimer interface [polypeptide binding]; other site 315750001669 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 315750001670 Glutamine amidotransferase class-I; Region: GATase; pfam00117 315750001671 predicted active site [active] 315750001672 catalytic triad [active] 315750001673 seryl-tRNA synthetase; Provisional; Region: PRK05431 315750001674 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315750001675 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 315750001676 dimer interface [polypeptide binding]; other site 315750001677 active site 315750001678 motif 1; other site 315750001679 motif 2; other site 315750001680 motif 3; other site 315750001681 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750001682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750001683 dimer interface [polypeptide binding]; other site 315750001684 putative CheW interface [polypeptide binding]; other site 315750001685 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315750001686 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315750001687 Substrate-binding site [chemical binding]; other site 315750001688 Substrate specificity [chemical binding]; other site 315750001689 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315750001690 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315750001691 Substrate-binding site [chemical binding]; other site 315750001692 Substrate specificity [chemical binding]; other site 315750001693 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 315750001694 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750001695 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750001696 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 315750001697 active site 315750001698 Isochorismatase family; Region: Isochorismatase; pfam00857 315750001699 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315750001700 catalytic triad [active] 315750001701 conserved cis-peptide bond; other site 315750001702 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 315750001703 nucleoside/Zn binding site; other site 315750001704 dimer interface [polypeptide binding]; other site 315750001705 catalytic motif [active] 315750001706 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 315750001707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750001708 Walker A motif; other site 315750001709 ATP binding site [chemical binding]; other site 315750001710 Walker B motif; other site 315750001711 arginine finger; other site 315750001712 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 315750001713 hypothetical protein; Validated; Region: PRK00153 315750001714 recombination protein RecR; Reviewed; Region: recR; PRK00076 315750001715 RecR protein; Region: RecR; pfam02132 315750001716 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 315750001717 putative active site [active] 315750001718 putative metal-binding site [ion binding]; other site 315750001719 tetramer interface [polypeptide binding]; other site 315750001720 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 315750001721 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 315750001722 thiamine monophosphate kinase; Provisional; Region: PRK05731 315750001723 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 315750001724 ATP binding site [chemical binding]; other site 315750001725 dimerization interface [polypeptide binding]; other site 315750001726 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 315750001727 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 315750001728 Glycoprotease family; Region: Peptidase_M22; pfam00814 315750001729 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315750001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001731 Coenzyme A binding pocket [chemical binding]; other site 315750001732 UGMP family protein; Validated; Region: PRK09604 315750001733 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 315750001734 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750001735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750001736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750001737 ABC transporter; Region: ABC_tran_2; pfam12848 315750001738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750001739 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 315750001740 trimer interface [polypeptide binding]; other site 315750001741 dimer interface [polypeptide binding]; other site 315750001742 putative active site [active] 315750001743 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 315750001744 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 315750001745 CoA binding domain; Region: CoA_binding; pfam02629 315750001746 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 315750001747 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 315750001748 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 315750001749 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315750001750 nudix motif; other site 315750001751 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 315750001752 CAAX protease self-immunity; Region: Abi; pfam02517 315750001753 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 315750001754 oligomerisation interface [polypeptide binding]; other site 315750001755 mobile loop; other site 315750001756 roof hairpin; other site 315750001757 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 315750001758 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 315750001759 ring oligomerisation interface [polypeptide binding]; other site 315750001760 ATP/Mg binding site [chemical binding]; other site 315750001761 stacking interactions; other site 315750001762 hinge regions; other site 315750001763 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 315750001764 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 315750001765 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 315750001766 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 315750001767 Multicopper oxidase; Region: Cu-oxidase; pfam00394 315750001768 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 315750001769 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 315750001770 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315750001771 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 315750001772 MoxR-like ATPases [General function prediction only]; Region: COG0714 315750001773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750001774 Walker A motif; other site 315750001775 ATP binding site [chemical binding]; other site 315750001776 Walker B motif; other site 315750001777 arginine finger; other site 315750001778 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 315750001779 Protein of unknown function DUF58; Region: DUF58; pfam01882 315750001780 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 315750001781 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 315750001782 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 315750001783 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 315750001784 GMP synthase; Reviewed; Region: guaA; PRK00074 315750001785 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 315750001786 AMP/PPi binding site [chemical binding]; other site 315750001787 candidate oxyanion hole; other site 315750001788 catalytic triad [active] 315750001789 potential glutamine specificity residues [chemical binding]; other site 315750001790 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 315750001791 ATP Binding subdomain [chemical binding]; other site 315750001792 Ligand Binding sites [chemical binding]; other site 315750001793 Dimerization subdomain; other site 315750001794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750001795 non-specific DNA binding site [nucleotide binding]; other site 315750001796 salt bridge; other site 315750001797 sequence-specific DNA binding site [nucleotide binding]; other site 315750001798 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750001799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750001800 sequence-specific DNA binding site [nucleotide binding]; other site 315750001801 salt bridge; other site 315750001802 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315750001803 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315750001804 Replication initiation factor; Region: Rep_trans; pfam02486 315750001805 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 315750001806 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 315750001807 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315750001808 cofactor binding site; other site 315750001809 DNA binding site [nucleotide binding] 315750001810 substrate interaction site [chemical binding]; other site 315750001811 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 315750001812 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 315750001813 Walker A motif; other site 315750001814 ATP binding site [chemical binding]; other site 315750001815 Walker B motif; other site 315750001816 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 315750001817 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 315750001818 TcpE family; Region: TcpE; pfam12648 315750001819 hypothetical protein; Provisional; Region: PHA02940 315750001820 AAA-like domain; Region: AAA_10; pfam12846 315750001821 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 315750001822 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315750001823 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750001824 catalytic residue [active] 315750001825 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750001826 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750001827 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 315750001828 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 315750001829 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 315750001830 Int/Topo IB signature motif; other site 315750001831 Cupin domain; Region: Cupin_2; cl17218 315750001832 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750001833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001834 2-isopropylmalate synthase; Validated; Region: PRK03739 315750001835 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 315750001836 active site 315750001837 catalytic residues [active] 315750001838 metal binding site [ion binding]; metal-binding site 315750001839 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 315750001840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750001842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001843 Helix-turn-helix domain; Region: HTH_18; pfam12833 315750001844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 315750001845 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750001846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750001847 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750001848 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750001849 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315750001850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750001851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750001852 DNA binding residues [nucleotide binding] 315750001853 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315750001854 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750001855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001856 putative substrate translocation pore; other site 315750001857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750001858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750001859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750001860 dimerization interface [polypeptide binding]; other site 315750001861 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315750001862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 315750001863 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315750001864 NETI protein; Region: NETI; pfam14044 315750001865 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 315750001866 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 315750001867 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 315750001868 NAD binding site [chemical binding]; other site 315750001869 ATP-grasp domain; Region: ATP-grasp; pfam02222 315750001870 adenylosuccinate lyase; Provisional; Region: PRK07492 315750001871 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 315750001872 tetramer interface [polypeptide binding]; other site 315750001873 active site 315750001874 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 315750001875 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 315750001876 ATP binding site [chemical binding]; other site 315750001877 active site 315750001878 substrate binding site [chemical binding]; other site 315750001879 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 315750001880 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 315750001881 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 315750001882 putative active site [active] 315750001883 catalytic triad [active] 315750001884 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 315750001885 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 315750001886 dimerization interface [polypeptide binding]; other site 315750001887 ATP binding site [chemical binding]; other site 315750001888 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 315750001889 dimerization interface [polypeptide binding]; other site 315750001890 ATP binding site [chemical binding]; other site 315750001891 amidophosphoribosyltransferase; Provisional; Region: PRK07631 315750001892 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 315750001893 active site 315750001894 tetramer interface [polypeptide binding]; other site 315750001895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750001896 active site 315750001897 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 315750001898 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 315750001899 dimerization interface [polypeptide binding]; other site 315750001900 putative ATP binding site [chemical binding]; other site 315750001901 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 315750001902 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 315750001903 active site 315750001904 substrate binding site [chemical binding]; other site 315750001905 cosubstrate binding site; other site 315750001906 catalytic site [active] 315750001907 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 315750001908 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 315750001909 purine monophosphate binding site [chemical binding]; other site 315750001910 dimer interface [polypeptide binding]; other site 315750001911 putative catalytic residues [active] 315750001912 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 315750001913 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 315750001914 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 315750001915 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 315750001916 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 315750001917 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 315750001918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750001919 ATP binding site [chemical binding]; other site 315750001920 putative Mg++ binding site [ion binding]; other site 315750001921 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 315750001922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001923 Coenzyme A binding pocket [chemical binding]; other site 315750001924 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 315750001925 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750001926 hypothetical protein; Provisional; Region: PRK06917 315750001927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750001928 inhibitor-cofactor binding pocket; inhibition site 315750001929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001930 catalytic residue [active] 315750001931 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 315750001932 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 315750001933 acetylornithine deacetylase; Validated; Region: PRK06915 315750001934 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 315750001935 metal binding site [ion binding]; metal-binding site 315750001936 dimer interface [polypeptide binding]; other site 315750001937 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 315750001938 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 315750001939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750001940 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 315750001941 active site 315750001942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750001943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 315750001944 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 315750001945 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315750001946 active site 315750001947 FMN binding site [chemical binding]; other site 315750001948 substrate binding site [chemical binding]; other site 315750001949 3Fe-4S cluster binding site [ion binding]; other site 315750001950 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 315750001951 PcrB family; Region: PcrB; pfam01884 315750001952 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 315750001953 substrate binding site [chemical binding]; other site 315750001954 putative active site [active] 315750001955 dimer interface [polypeptide binding]; other site 315750001956 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 315750001957 Part of AAA domain; Region: AAA_19; pfam13245 315750001958 Family description; Region: UvrD_C_2; pfam13538 315750001959 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 315750001960 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 315750001961 nucleotide binding pocket [chemical binding]; other site 315750001962 K-X-D-G motif; other site 315750001963 catalytic site [active] 315750001964 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 315750001965 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 315750001966 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 315750001967 Dimer interface [polypeptide binding]; other site 315750001968 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 315750001969 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 315750001970 putative dimer interface [polypeptide binding]; other site 315750001971 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 315750001972 putative dimer interface [polypeptide binding]; other site 315750001973 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001975 Condensation domain; Region: Condensation; pfam00668 315750001976 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315750001977 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 315750001978 acyl-activating enzyme (AAE) consensus motif; other site 315750001979 AMP binding site [chemical binding]; other site 315750001980 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750001981 Condensation domain; Region: Condensation; pfam00668 315750001982 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001983 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315750001984 Beta-lactamase; Region: Beta-lactamase; pfam00144 315750001985 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 315750001986 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 315750001987 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 315750001988 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750001989 FkbH-like domain; Region: FkbH; TIGR01686 315750001990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750001991 active site 315750001992 motif I; other site 315750001993 motif II; other site 315750001994 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 315750001995 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750001996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315750001997 active site 315750001998 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001999 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315750002000 acyl-activating enzyme (AAE) consensus motif; other site 315750002001 AMP binding site [chemical binding]; other site 315750002002 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750002003 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750002004 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 315750002005 active site 315750002006 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 315750002007 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750002008 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 315750002009 putative NADP binding site [chemical binding]; other site 315750002010 active site 315750002011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750002012 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750002013 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 315750002014 active site 315750002015 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315750002016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750002017 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 315750002018 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750002019 active site 315750002020 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 315750002021 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750002022 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 315750002023 putative NADP binding site [chemical binding]; other site 315750002024 active site 315750002025 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750002026 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750002027 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 315750002028 active site 315750002029 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 315750002030 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750002031 Condensation domain; Region: Condensation; pfam00668 315750002032 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750002033 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750002034 FkbH-like domain; Region: FkbH; TIGR01686 315750002035 Acid Phosphatase; Region: Acid_PPase; cl17256 315750002036 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315750002037 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 315750002038 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315750002039 active site 315750002040 ATP binding site [chemical binding]; other site 315750002041 substrate binding site [chemical binding]; other site 315750002042 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 315750002043 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315750002044 dimer interface [polypeptide binding]; other site 315750002045 active site 315750002046 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 315750002047 MgtC family; Region: MgtC; pfam02308 315750002048 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 315750002049 Na binding site [ion binding]; other site 315750002050 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 315750002051 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 315750002052 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 315750002053 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 315750002054 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 315750002055 GatB domain; Region: GatB_Yqey; pfam02637 315750002056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750002058 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315750002059 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315750002060 Protein export membrane protein; Region: SecD_SecF; cl14618 315750002061 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 315750002062 active site 315750002063 dimerization interface [polypeptide binding]; other site 315750002064 putative lipid kinase; Reviewed; Region: PRK13337 315750002065 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 315750002066 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 315750002067 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315750002068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750002069 S-adenosylmethionine binding site [chemical binding]; other site 315750002070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002071 ATP binding site [chemical binding]; other site 315750002072 Mg2+ binding site [ion binding]; other site 315750002073 G-X-G motif; other site 315750002074 Z1 domain; Region: Z1; pfam10593 315750002075 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 315750002076 AIPR protein; Region: AIPR; pfam10592 315750002077 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315750002078 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 315750002079 cofactor binding site; other site 315750002080 DNA binding site [nucleotide binding] 315750002081 substrate interaction site [chemical binding]; other site 315750002082 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 315750002083 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315750002084 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315750002085 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 315750002086 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315750002087 FMN binding site [chemical binding]; other site 315750002088 active site 315750002089 catalytic residues [active] 315750002090 substrate binding site [chemical binding]; other site 315750002091 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315750002092 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750002093 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750002094 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750002095 putative active site [active] 315750002096 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 315750002097 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750002098 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750002099 active site turn [active] 315750002100 phosphorylation site [posttranslational modification] 315750002101 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315750002102 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 315750002103 NAD binding site [chemical binding]; other site 315750002104 sugar binding site [chemical binding]; other site 315750002105 divalent metal binding site [ion binding]; other site 315750002106 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750002107 dimer interface [polypeptide binding]; other site 315750002108 Rrf2 family protein; Region: rrf2_super; TIGR00738 315750002109 Transcriptional regulator; Region: Rrf2; pfam02082 315750002110 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315750002111 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 315750002112 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315750002113 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 315750002114 NAD binding site [chemical binding]; other site 315750002115 sugar binding site [chemical binding]; other site 315750002116 divalent metal binding site [ion binding]; other site 315750002117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750002118 dimer interface [polypeptide binding]; other site 315750002119 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750002120 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750002121 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750002122 putative active site [active] 315750002123 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 315750002124 putative deacylase active site [active] 315750002125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750002126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750002127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750002128 dimerization interface [polypeptide binding]; other site 315750002129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002131 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 315750002132 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 315750002133 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315750002134 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 315750002135 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 315750002136 substrate binding site; other site 315750002137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002138 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315750002139 NAD(P) binding site [chemical binding]; other site 315750002140 active site 315750002141 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 315750002142 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750002143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750002144 active site 315750002145 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 315750002146 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 315750002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002149 putative substrate translocation pore; other site 315750002150 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 315750002151 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750002152 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750002153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750002154 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 315750002155 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 315750002156 transmembrane helices; other site 315750002157 Spore germination protein GerPC; Region: GerPC; pfam10737 315750002158 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 315750002159 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 315750002160 putative dimer interface [polypeptide binding]; other site 315750002161 amino acid transporter; Region: 2A0306; TIGR00909 315750002162 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 315750002163 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750002164 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315750002165 putative metal binding site; other site 315750002166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750002167 binding surface 315750002168 TPR motif; other site 315750002169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750002170 binding surface 315750002171 TPR motif; other site 315750002172 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750002173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750002174 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750002175 ABC transporter; Region: ABC_tran_2; pfam12848 315750002176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750002177 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315750002178 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315750002179 DNA binding residues [nucleotide binding] 315750002180 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750002181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002182 putative substrate translocation pore; other site 315750002183 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750002184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750002185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750002186 ABC transporter; Region: ABC_tran_2; pfam12848 315750002187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750002188 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750002189 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750002190 ATP binding site [chemical binding]; other site 315750002191 Mg++ binding site [ion binding]; other site 315750002192 motif III; other site 315750002193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750002194 nucleotide binding region [chemical binding]; other site 315750002195 ATP-binding site [chemical binding]; other site 315750002196 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 315750002197 Prostaglandin dehydrogenases; Region: PGDH; cd05288 315750002198 NAD(P) binding site [chemical binding]; other site 315750002199 substrate binding site [chemical binding]; other site 315750002200 dimer interface [polypeptide binding]; other site 315750002201 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 315750002202 Heat induced stress protein YflT; Region: YflT; pfam11181 315750002203 Predicted AdoMet-dependent methyltransferase; Region: AdoMet_MTase; pfam07757 315750002204 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315750002205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750002206 S-adenosylmethionine binding site [chemical binding]; other site 315750002207 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 315750002208 dimerization interface [polypeptide binding]; other site 315750002209 active site 315750002210 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 315750002211 structural tetrad; other site 315750002212 FOG: WD40 repeat [General function prediction only]; Region: COG2319 315750002213 FOG: WD40 repeat [General function prediction only]; Region: COG2319 315750002214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 315750002215 structural tetrad; other site 315750002216 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 315750002217 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 315750002218 catalytic motif [active] 315750002219 Zn binding site [ion binding]; other site 315750002220 RibD C-terminal domain; Region: RibD_C; cl17279 315750002221 BclB C-terminal domain; Region: exospore_TM; TIGR03721 315750002222 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315750002223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002224 ATP binding site [chemical binding]; other site 315750002225 Mg2+ binding site [ion binding]; other site 315750002226 G-X-G motif; other site 315750002227 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315750002228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750002229 active site 315750002230 phosphorylation site [posttranslational modification] 315750002231 intermolecular recognition site; other site 315750002232 dimerization interface [polypeptide binding]; other site 315750002233 HTH domain; Region: HTH_11; cl17392 315750002234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 315750002235 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 315750002236 Citrate transporter; Region: CitMHS; pfam03600 315750002237 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 315750002238 active site 315750002239 Zn binding site [ion binding]; other site 315750002240 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 315750002241 Predicted transcriptional regulators [Transcription]; Region: COG1695 315750002242 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315750002243 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 315750002244 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 315750002245 active site 315750002246 dimer interface [polypeptide binding]; other site 315750002247 Acylphosphatase; Region: Acylphosphatase; cl00551 315750002248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 315750002249 MOSC domain; Region: MOSC; pfam03473 315750002250 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 315750002251 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315750002252 active site 315750002253 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750002254 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 315750002255 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750002256 active site turn [active] 315750002257 phosphorylation site [posttranslational modification] 315750002258 Protein of unknown function (DUF817); Region: DUF817; pfam05675 315750002259 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 315750002260 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750002261 Sulfatase; Region: Sulfatase; pfam00884 315750002262 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 315750002263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315750002264 catalytic residue [active] 315750002265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750002266 dimerization interface [polypeptide binding]; other site 315750002267 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750002268 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750002269 dimer interface [polypeptide binding]; other site 315750002270 putative CheW interface [polypeptide binding]; other site 315750002271 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 315750002272 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750002273 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 315750002274 active site turn [active] 315750002275 phosphorylation site [posttranslational modification] 315750002276 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750002277 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315750002278 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315750002279 Ca binding site [ion binding]; other site 315750002280 active site 315750002281 catalytic site [active] 315750002282 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 315750002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750002284 DNA-binding site [nucleotide binding]; DNA binding site 315750002285 UTRA domain; Region: UTRA; pfam07702 315750002286 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 315750002287 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315750002288 active site 315750002289 metal binding site [ion binding]; metal-binding site 315750002290 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750002291 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315750002292 active site 315750002293 metal binding site [ion binding]; metal-binding site 315750002294 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750002295 intracellular protease, PfpI family; Region: PfpI; TIGR01382 315750002296 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 315750002297 proposed catalytic triad [active] 315750002298 conserved cys residue [active] 315750002299 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 315750002300 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315750002301 amino acid carrier protein; Region: agcS; TIGR00835 315750002302 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 315750002303 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315750002304 active site 315750002305 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 315750002306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002308 putative substrate translocation pore; other site 315750002309 OsmC-like protein; Region: OsmC; pfam02566 315750002310 calcium/proton exchanger (cax); Region: cax; TIGR00378 315750002311 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315750002312 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315750002313 YfkD-like protein; Region: YfkD; pfam14167 315750002314 hypothetical protein; Provisional; Region: PRK12378 315750002315 SnoaL-like domain; Region: SnoaL_2; pfam12680 315750002316 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 315750002317 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315750002318 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 315750002319 YfkB-like domain; Region: YfkB; pfam08756 315750002320 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 315750002321 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 315750002322 NodB motif; other site 315750002323 active site 315750002324 catalytic site [active] 315750002325 Cd binding site [ion binding]; other site 315750002326 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 315750002327 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 315750002328 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 315750002329 oligomer interface [polypeptide binding]; other site 315750002330 metal binding site [ion binding]; metal-binding site 315750002331 metal binding site [ion binding]; metal-binding site 315750002332 putative Cl binding site [ion binding]; other site 315750002333 aspartate ring; other site 315750002334 basic sphincter; other site 315750002335 hydrophobic gate; other site 315750002336 periplasmic entrance; other site 315750002337 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 315750002338 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315750002339 minor groove reading motif; other site 315750002340 helix-hairpin-helix signature motif; other site 315750002341 substrate binding pocket [chemical binding]; other site 315750002342 active site 315750002343 TRAM domain; Region: TRAM; pfam01938 315750002344 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315750002345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750002346 S-adenosylmethionine binding site [chemical binding]; other site 315750002347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750002349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315750002350 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 315750002351 putative NAD(P) binding site [chemical binding]; other site 315750002352 active site 315750002353 putative substrate binding site [chemical binding]; other site 315750002354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750002355 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 315750002356 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750002357 DNA binding residues [nucleotide binding] 315750002358 drug binding residues [chemical binding]; other site 315750002359 dimer interface [polypeptide binding]; other site 315750002360 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 315750002361 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002363 putative substrate translocation pore; other site 315750002364 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 315750002365 Protein of unknown function; Region: DUF3658; pfam12395 315750002366 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 315750002367 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315750002368 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315750002369 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315750002370 active site 315750002371 dimer interface [polypeptide binding]; other site 315750002372 motif 1; other site 315750002373 motif 2; other site 315750002374 motif 3; other site 315750002375 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315750002376 anticodon binding site; other site 315750002377 Mga helix-turn-helix domain; Region: Mga; pfam05043 315750002378 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315750002379 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002380 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002381 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002382 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002383 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002384 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002385 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002386 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002387 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002388 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315750002389 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002390 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002391 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002392 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002393 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002394 Cna protein B-type domain; Region: Cna_B; pfam05738 315750002395 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 315750002396 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 315750002397 active site 315750002398 catalytic site [active] 315750002399 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315750002400 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315750002401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750002403 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 315750002404 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 315750002405 active site 315750002406 catalytic triad [active] 315750002407 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315750002408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750002409 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315750002410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750002411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750002412 DNA binding residues [nucleotide binding] 315750002413 Putative zinc-finger; Region: zf-HC2; pfam13490 315750002414 putative anti-sigmaE protein; Provisional; Region: PRK13920 315750002415 Anti-sigma-K factor rskA; Region: RskA; pfam10099 315750002416 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 315750002417 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 315750002418 putative NAD(P) binding site [chemical binding]; other site 315750002419 dimer interface [polypeptide binding]; other site 315750002420 metal-dependent hydrolase; Provisional; Region: PRK13291 315750002421 DinB superfamily; Region: DinB_2; pfam12867 315750002422 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750002423 MarR family; Region: MarR; pfam01047 315750002424 Predicted integral membrane protein [Function unknown]; Region: COG0392 315750002425 Uncharacterized conserved protein [Function unknown]; Region: COG2898 315750002426 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 315750002427 Protein of unknown function, DUF393; Region: DUF393; pfam04134 315750002428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750002429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750002430 non-specific DNA binding site [nucleotide binding]; other site 315750002431 salt bridge; other site 315750002432 sequence-specific DNA binding site [nucleotide binding]; other site 315750002433 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 315750002434 putative FMN binding site [chemical binding]; other site 315750002435 YfhD-like protein; Region: YfhD; pfam14151 315750002436 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 315750002437 TIGR01777 family protein; Region: yfcH 315750002438 putative NAD(P) binding site [chemical binding]; other site 315750002439 putative active site [active] 315750002440 recombination regulator RecX; Provisional; Region: recX; PRK14135 315750002441 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 315750002442 YpzG-like protein; Region: YpzG; pfam14139 315750002443 Small acid-soluble spore protein K family; Region: SspK; pfam08176 315750002444 WVELL protein; Region: WVELL; pfam14043 315750002445 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 315750002446 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 315750002447 Ligand binding site; other site 315750002448 Putative Catalytic site; other site 315750002449 DXD motif; other site 315750002450 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 315750002451 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 315750002452 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 315750002453 DinB superfamily; Region: DinB_2; pfam12867 315750002454 Regulatory protein YrvL; Region: YrvL; pfam14184 315750002455 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 315750002456 Cupin; Region: Cupin_1; smart00835 315750002457 Cupin; Region: Cupin_1; smart00835 315750002458 YvrJ protein family; Region: YvrJ; pfam12841 315750002459 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315750002460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750002461 DNA binding residues [nucleotide binding] 315750002462 hypothetical protein; Provisional; Region: PRK14082 315750002463 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 315750002464 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 315750002465 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315750002466 minor groove reading motif; other site 315750002467 helix-hairpin-helix signature motif; other site 315750002468 substrate binding pocket [chemical binding]; other site 315750002469 active site 315750002470 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 315750002471 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 315750002472 DNA binding and oxoG recognition site [nucleotide binding] 315750002473 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 315750002474 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 315750002475 putative NAD(P) binding site [chemical binding]; other site 315750002476 active site 315750002477 Transposase domain (DUF772); Region: DUF772; pfam05598 315750002478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750002479 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750002480 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 315750002481 YgaB-like protein; Region: YgaB; pfam14182 315750002482 hypothetical protein; Provisional; Region: PRK13662 315750002483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750002484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750002485 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 315750002486 Walker A/P-loop; other site 315750002487 ATP binding site [chemical binding]; other site 315750002488 Q-loop/lid; other site 315750002489 ABC transporter signature motif; other site 315750002490 Walker B; other site 315750002491 D-loop; other site 315750002492 H-loop/switch region; other site 315750002493 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750002494 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750002495 Walker A/P-loop; other site 315750002496 ATP binding site [chemical binding]; other site 315750002497 Q-loop/lid; other site 315750002498 ABC transporter signature motif; other site 315750002499 Walker B; other site 315750002500 D-loop; other site 315750002501 H-loop/switch region; other site 315750002502 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315750002503 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750002504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750002505 Walker A/P-loop; other site 315750002506 ATP binding site [chemical binding]; other site 315750002507 Q-loop/lid; other site 315750002508 ABC transporter signature motif; other site 315750002509 Walker B; other site 315750002510 D-loop; other site 315750002511 H-loop/switch region; other site 315750002512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750002513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315750002514 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 315750002515 peptide binding site [polypeptide binding]; other site 315750002516 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750002517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750002518 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 315750002519 conserved gate region; other site 315750002520 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750002521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750002523 dimer interface [polypeptide binding]; other site 315750002524 conserved gate region; other site 315750002525 putative PBP binding loops; other site 315750002526 ABC-ATPase subunit interface; other site 315750002527 Predicted membrane protein [Function unknown]; Region: COG4129 315750002528 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 315750002529 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 315750002530 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750002531 inhibitor-cofactor binding pocket; inhibition site 315750002532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002533 catalytic residue [active] 315750002534 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 315750002535 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 315750002536 catalytic triad [active] 315750002537 ferric uptake regulator; Provisional; Region: fur; PRK09462 315750002538 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315750002539 metal binding site 2 [ion binding]; metal-binding site 315750002540 putative DNA binding helix; other site 315750002541 metal binding site 1 [ion binding]; metal-binding site 315750002542 dimer interface [polypeptide binding]; other site 315750002543 structural Zn2+ binding site [ion binding]; other site 315750002544 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 315750002545 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315750002546 Phosphotransferase enzyme family; Region: APH; pfam01636 315750002547 active site 315750002548 substrate binding site [chemical binding]; other site 315750002549 ATP binding site [chemical binding]; other site 315750002550 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315750002551 catalytic core [active] 315750002552 Bacitracin resistance protein BacA; Region: BacA; cl00858 315750002553 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 315750002554 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 315750002555 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750002556 Sulfatase; Region: Sulfatase; pfam00884 315750002557 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315750002558 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315750002559 Catalytic site [active] 315750002560 Transposase domain (DUF772); Region: DUF772; pfam05598 315750002561 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750002562 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750002563 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 315750002564 putative binding site; other site 315750002565 putative dimer interface [polypeptide binding]; other site 315750002566 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 315750002567 Putative amidase domain; Region: Amidase_6; pfam12671 315750002568 epoxyqueuosine reductase; Region: TIGR00276 315750002569 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 315750002570 HEAT repeats; Region: HEAT_2; pfam13646 315750002571 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 315750002572 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 315750002573 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 315750002574 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750002575 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750002576 Walker A/P-loop; other site 315750002577 ATP binding site [chemical binding]; other site 315750002578 Q-loop/lid; other site 315750002579 ABC transporter signature motif; other site 315750002580 Walker B; other site 315750002581 D-loop; other site 315750002582 H-loop/switch region; other site 315750002583 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 315750002584 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750002585 homodimer interface [polypeptide binding]; other site 315750002586 substrate-cofactor binding pocket; other site 315750002587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002588 catalytic residue [active] 315750002589 similar to hypothetical protein 315750002590 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 315750002591 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 315750002592 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 315750002593 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 315750002594 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750002595 E3 interaction surface; other site 315750002596 lipoyl attachment site [posttranslational modification]; other site 315750002597 HlyD family secretion protein; Region: HlyD_3; pfam13437 315750002598 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315750002599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002600 putative substrate translocation pore; other site 315750002601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002602 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750002603 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 315750002604 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315750002605 DNA-binding site [nucleotide binding]; DNA binding site 315750002606 RNA-binding motif; other site 315750002607 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315750002608 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315750002609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750002610 metal binding site [ion binding]; metal-binding site 315750002611 active site 315750002612 I-site; other site 315750002613 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 315750002614 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750002615 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 315750002616 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 315750002617 CheB methylesterase; Region: CheB_methylest; pfam01339 315750002618 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315750002619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750002620 S-adenosylmethionine binding site [chemical binding]; other site 315750002621 PAS domain; Region: PAS_10; pfam13596 315750002622 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 315750002623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750002624 putative active site [active] 315750002625 heme pocket [chemical binding]; other site 315750002626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750002627 dimer interface [polypeptide binding]; other site 315750002628 phosphorylation site [posttranslational modification] 315750002629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002630 ATP binding site [chemical binding]; other site 315750002631 Mg2+ binding site [ion binding]; other site 315750002632 G-X-G motif; other site 315750002633 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 315750002634 generic binding surface II; other site 315750002635 generic binding surface I; other site 315750002636 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 315750002637 generic binding surface II; other site 315750002638 generic binding surface I; other site 315750002639 Staphylococcal nuclease homologues; Region: SNc; smart00318 315750002640 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 315750002641 Catalytic site; other site 315750002642 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315750002643 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 315750002644 putative active site [active] 315750002645 putative metal binding site [ion binding]; other site 315750002646 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750002647 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315750002648 active site 315750002649 catalytic site [active] 315750002650 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315750002651 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 315750002652 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315750002653 active site 315750002654 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 315750002655 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315750002656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750002657 motif II; other site 315750002658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750002659 Coenzyme A binding pocket [chemical binding]; other site 315750002660 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315750002661 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 315750002662 putative active site [active] 315750002663 catalytic triad [active] 315750002664 putative dimer interface [polypeptide binding]; other site 315750002665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 315750002666 Predicted permeases [General function prediction only]; Region: COG0679 315750002667 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 315750002668 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750002669 aminotransferase; Validated; Region: PRK07678 315750002670 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750002671 inhibitor-cofactor binding pocket; inhibition site 315750002672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002673 catalytic residue [active] 315750002674 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 315750002675 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 315750002676 amphipathic channel; other site 315750002677 Asn-Pro-Ala signature motifs; other site 315750002678 glycerol kinase; Provisional; Region: glpK; PRK00047 315750002679 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 315750002680 N- and C-terminal domain interface [polypeptide binding]; other site 315750002681 active site 315750002682 MgATP binding site [chemical binding]; other site 315750002683 catalytic site [active] 315750002684 metal binding site [ion binding]; metal-binding site 315750002685 glycerol binding site [chemical binding]; other site 315750002686 homotetramer interface [polypeptide binding]; other site 315750002687 homodimer interface [polypeptide binding]; other site 315750002688 FBP binding site [chemical binding]; other site 315750002689 protein IIAGlc interface [polypeptide binding]; other site 315750002690 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 315750002691 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 315750002692 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 315750002693 active site 315750002694 substrate binding site [chemical binding]; other site 315750002695 metal binding site [ion binding]; metal-binding site 315750002696 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 315750002697 GAF domain; Region: GAF_3; pfam13492 315750002698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750002699 Histidine kinase; Region: HisKA_3; pfam07730 315750002700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002701 ATP binding site [chemical binding]; other site 315750002702 Mg2+ binding site [ion binding]; other site 315750002703 G-X-G motif; other site 315750002704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750002705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750002706 active site 315750002707 phosphorylation site [posttranslational modification] 315750002708 intermolecular recognition site; other site 315750002709 dimerization interface [polypeptide binding]; other site 315750002710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750002711 DNA binding residues [nucleotide binding] 315750002712 dimerization interface [polypeptide binding]; other site 315750002713 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315750002714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750002715 Coenzyme A binding pocket [chemical binding]; other site 315750002716 YhdB-like protein; Region: YhdB; pfam14148 315750002717 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 315750002718 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315750002719 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 315750002720 tetramer interface [polypeptide binding]; other site 315750002721 heme binding pocket [chemical binding]; other site 315750002722 Transcriptional regulator; Region: Rrf2; cl17282 315750002723 Predicted transcriptional regulator [Transcription]; Region: COG1959 315750002724 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 315750002725 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 315750002726 heme-binding site [chemical binding]; other site 315750002727 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 315750002728 FAD binding pocket [chemical binding]; other site 315750002729 FAD binding motif [chemical binding]; other site 315750002730 phosphate binding motif [ion binding]; other site 315750002731 beta-alpha-beta structure motif; other site 315750002732 NAD binding pocket [chemical binding]; other site 315750002733 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 315750002734 SpoVR like protein; Region: SpoVR; pfam04293 315750002735 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 315750002736 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315750002737 dimer interface [polypeptide binding]; other site 315750002738 active site 315750002739 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 315750002740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750002741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750002742 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750002743 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750002744 Transposase; Region: HTH_Tnp_1; pfam01527 315750002745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 315750002746 putative transposase OrfB; Reviewed; Region: PHA02517 315750002747 HTH-like domain; Region: HTH_21; pfam13276 315750002748 Integrase core domain; Region: rve; pfam00665 315750002749 Integrase core domain; Region: rve_2; pfam13333 315750002750 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315750002751 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315750002752 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 315750002753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750002754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750002755 DNA binding residues [nucleotide binding] 315750002756 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 315750002757 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315750002758 putative acyl-acceptor binding pocket; other site 315750002759 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315750002760 Domain of unknown function DUF21; Region: DUF21; pfam01595 315750002761 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315750002762 Transporter associated domain; Region: CorC_HlyC; smart01091 315750002763 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 315750002764 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750002765 DNA binding residues [nucleotide binding] 315750002766 putative dimer interface [polypeptide binding]; other site 315750002767 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315750002768 Domain of unknown function DUF21; Region: DUF21; pfam01595 315750002769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315750002770 Transporter associated domain; Region: CorC_HlyC; smart01091 315750002771 CrcB-like protein; Region: CRCB; pfam02537 315750002772 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 315750002773 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 315750002774 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315750002775 active site 315750002776 catalytic site [active] 315750002777 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 315750002778 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315750002779 NAD-dependent deacetylase; Provisional; Region: PRK00481 315750002780 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 315750002781 NAD+ binding site [chemical binding]; other site 315750002782 substrate binding site [chemical binding]; other site 315750002783 Zn binding site [ion binding]; other site 315750002784 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750002785 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315750002786 NodB motif; other site 315750002787 active site 315750002788 catalytic site [active] 315750002789 Zn binding site [ion binding]; other site 315750002790 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315750002791 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315750002792 homodimer interface [polypeptide binding]; other site 315750002793 substrate-cofactor binding pocket; other site 315750002794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002795 catalytic residue [active] 315750002796 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 315750002797 Ligand Binding Site [chemical binding]; other site 315750002798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750002799 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 315750002800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750002801 Walker A/P-loop; other site 315750002802 ATP binding site [chemical binding]; other site 315750002803 Q-loop/lid; other site 315750002804 ABC transporter signature motif; other site 315750002805 Walker B; other site 315750002806 D-loop; other site 315750002807 H-loop/switch region; other site 315750002808 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750002809 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 315750002810 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 315750002811 Walker A/P-loop; other site 315750002812 ATP binding site [chemical binding]; other site 315750002813 Q-loop/lid; other site 315750002814 ABC transporter signature motif; other site 315750002815 Walker B; other site 315750002816 D-loop; other site 315750002817 H-loop/switch region; other site 315750002818 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315750002819 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315750002820 NAD binding site [chemical binding]; other site 315750002821 substrate binding site [chemical binding]; other site 315750002822 putative active site [active] 315750002823 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750002824 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315750002825 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 315750002826 Walker A/P-loop; other site 315750002827 ATP binding site [chemical binding]; other site 315750002828 Q-loop/lid; other site 315750002829 ABC transporter signature motif; other site 315750002830 Walker B; other site 315750002831 D-loop; other site 315750002832 H-loop/switch region; other site 315750002833 TOBE domain; Region: TOBE; pfam03459 315750002834 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750002835 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 315750002836 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 315750002837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 315750002838 hypothetical protein; Provisional; Region: PRK13676 315750002839 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 315750002840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750002841 active site 315750002842 motif I; other site 315750002843 motif II; other site 315750002844 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 315750002845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750002846 FeS/SAM binding site; other site 315750002847 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 315750002848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750002849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750002850 enoyl-CoA hydratase; Provisional; Region: PRK07659 315750002851 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750002852 substrate binding site [chemical binding]; other site 315750002853 oxyanion hole (OAH) forming residues; other site 315750002854 trimer interface [polypeptide binding]; other site 315750002855 YhzD-like protein; Region: YhzD; pfam14120 315750002856 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315750002857 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 315750002858 active site 315750002859 metal binding site [ion binding]; metal-binding site 315750002860 DNA binding site [nucleotide binding] 315750002861 Uncharacterized conserved protein [Function unknown]; Region: COG4717 315750002862 Aphid transmission protein; Region: Cauli_AT; pfam03233 315750002863 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 315750002864 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 315750002865 generic binding surface I; other site 315750002866 generic binding surface II; other site 315750002867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750002868 Zn2+ binding site [ion binding]; other site 315750002869 Mg2+ binding site [ion binding]; other site 315750002870 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 315750002871 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 315750002872 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 315750002873 similar to hypothetical protein 315750002874 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 315750002875 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 315750002876 transcriptional regulator Hpr; Provisional; Region: PRK13777 315750002877 MarR family; Region: MarR; pfam01047 315750002878 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 315750002879 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 315750002880 homodimer interface [polypeptide binding]; other site 315750002881 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 315750002882 substrate-cofactor binding pocket; other site 315750002883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002884 catalytic residue [active] 315750002885 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 315750002886 HIT family signature motif; other site 315750002887 catalytic residue [active] 315750002888 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750002889 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750002890 Walker A/P-loop; other site 315750002891 ATP binding site [chemical binding]; other site 315750002892 Q-loop/lid; other site 315750002893 ABC transporter signature motif; other site 315750002894 Walker B; other site 315750002895 D-loop; other site 315750002896 H-loop/switch region; other site 315750002897 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 315750002898 EcsC protein family; Region: EcsC; pfam12787 315750002899 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315750002900 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315750002901 metal binding site [ion binding]; metal-binding site 315750002902 dimer interface [polypeptide binding]; other site 315750002903 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 315750002904 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 315750002905 Transglycosylase; Region: Transgly; pfam00912 315750002906 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750002907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750002908 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 315750002909 substrate binding site [chemical binding]; other site 315750002910 active site 315750002911 ferrochelatase; Provisional; Region: PRK12435 315750002912 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 315750002913 C-terminal domain interface [polypeptide binding]; other site 315750002914 active site 315750002915 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 315750002916 active site 315750002917 N-terminal domain interface [polypeptide binding]; other site 315750002918 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 315750002919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750002920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750002921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750002923 Predicted membrane protein [Function unknown]; Region: COG1511 315750002924 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315750002925 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 315750002926 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315750002927 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 315750002928 putative oligomer interface [polypeptide binding]; other site 315750002929 putative active site [active] 315750002930 metal binding site [ion binding]; metal-binding site 315750002931 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750002932 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750002933 YhfH-like protein; Region: YhfH; pfam14149 315750002934 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 315750002935 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315750002936 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 315750002937 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 315750002938 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 315750002939 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 315750002940 acyl-activating enzyme (AAE) consensus motif; other site 315750002941 putative AMP binding site [chemical binding]; other site 315750002942 putative active site [active] 315750002943 putative CoA binding site [chemical binding]; other site 315750002944 Peptidase family M48; Region: Peptidase_M48; pfam01435 315750002945 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315750002946 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315750002947 active site 315750002948 catalytic residues [active] 315750002949 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315750002950 catalytic core [active] 315750002951 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 315750002952 heme-binding site [chemical binding]; other site 315750002953 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750002954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750002955 dimer interface [polypeptide binding]; other site 315750002956 putative CheW interface [polypeptide binding]; other site 315750002957 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 315750002958 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315750002959 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 315750002960 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 315750002961 [2Fe-2S] cluster binding site [ion binding]; other site 315750002962 short chain dehydrogenase; Provisional; Region: PRK06701 315750002963 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 315750002964 NAD binding site [chemical binding]; other site 315750002965 metal binding site [ion binding]; metal-binding site 315750002966 active site 315750002967 A short protein domain of unknown function; Region: IDEAL; smart00914 315750002968 ComK protein; Region: ComK; pfam06338 315750002969 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 315750002970 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 315750002971 dimer interface [polypeptide binding]; other site 315750002972 active site 315750002973 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750002974 substrate binding site [chemical binding]; other site 315750002975 catalytic residue [active] 315750002976 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750002977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750002978 DNA-binding site [nucleotide binding]; DNA binding site 315750002979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750002980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002981 homodimer interface [polypeptide binding]; other site 315750002982 catalytic residue [active] 315750002983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002985 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 315750002986 RNAase interaction site [polypeptide binding]; other site 315750002987 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750002988 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750002989 ABC-ATPase subunit interface; other site 315750002990 dimer interface [polypeptide binding]; other site 315750002991 putative PBP binding regions; other site 315750002992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750002993 ABC-ATPase subunit interface; other site 315750002994 dimer interface [polypeptide binding]; other site 315750002995 putative PBP binding regions; other site 315750002996 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 315750002997 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750002998 Walker A/P-loop; other site 315750002999 ATP binding site [chemical binding]; other site 315750003000 Q-loop/lid; other site 315750003001 ABC transporter signature motif; other site 315750003002 Walker B; other site 315750003003 D-loop; other site 315750003004 H-loop/switch region; other site 315750003005 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 315750003006 putative ligand binding residues [chemical binding]; other site 315750003007 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750003008 Transcriptional regulator [Transcription]; Region: LytR; COG1316 315750003009 Uncharacterized conserved protein [Function unknown]; Region: COG0398 315750003010 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315750003011 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 315750003012 Putative ammonia monooxygenase; Region: AmoA; pfam05145 315750003013 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 315750003014 Peptidase family M48; Region: Peptidase_M48; cl12018 315750003015 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 315750003016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 315750003017 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 315750003018 Part of AAA domain; Region: AAA_19; pfam13245 315750003019 Family description; Region: UvrD_C_2; pfam13538 315750003020 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 315750003021 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 315750003022 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315750003023 active site 315750003024 metal binding site [ion binding]; metal-binding site 315750003025 DNA binding site [nucleotide binding] 315750003026 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 315750003027 exonuclease SbcC; Region: sbcc; TIGR00618 315750003028 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 315750003029 Walker A/P-loop; other site 315750003030 ATP binding site [chemical binding]; other site 315750003031 Q-loop/lid; other site 315750003032 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 315750003033 ABC transporter signature motif; other site 315750003034 Walker B; other site 315750003035 D-loop; other site 315750003036 H-loop/switch region; other site 315750003037 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315750003038 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750003039 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 315750003040 Spore germination protein GerPC; Region: GerPC; pfam10737 315750003041 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 315750003042 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750003043 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315750003044 CotH protein; Region: CotH; pfam08757 315750003045 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 315750003046 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 315750003047 hypothetical protein; Provisional; Region: PRK13673 315750003048 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 315750003049 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315750003050 active site 315750003051 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315750003052 dimer interface [polypeptide binding]; other site 315750003053 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315750003054 Ligand Binding Site [chemical binding]; other site 315750003055 Molecular Tunnel; other site 315750003056 phytoene desaturase; Region: crtI_fam; TIGR02734 315750003057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315750003058 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 315750003059 active site lid residues [active] 315750003060 substrate binding pocket [chemical binding]; other site 315750003061 catalytic residues [active] 315750003062 substrate-Mg2+ binding site; other site 315750003063 aspartate-rich region 1; other site 315750003064 aspartate-rich region 2; other site 315750003065 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315750003066 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 315750003067 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 315750003068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750003069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750003070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750003071 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750003072 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750003073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750003074 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 315750003075 trimer interface [polypeptide binding]; other site 315750003076 active site 315750003077 substrate binding site [chemical binding]; other site 315750003078 CoA binding site [chemical binding]; other site 315750003079 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 315750003080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750003081 inhibitor-cofactor binding pocket; inhibition site 315750003082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003083 catalytic residue [active] 315750003084 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 315750003085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003086 catalytic residue [active] 315750003087 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315750003088 IucA / IucC family; Region: IucA_IucC; pfam04183 315750003089 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315750003090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 315750003091 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 315750003092 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750003093 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 315750003094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750003095 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315750003096 IucA / IucC family; Region: IucA_IucC; pfam04183 315750003097 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315750003098 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750003099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003100 Coenzyme A binding pocket [chemical binding]; other site 315750003101 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 315750003102 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 315750003103 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 315750003104 substrate binding pocket [chemical binding]; other site 315750003105 dimer interface [polypeptide binding]; other site 315750003106 inhibitor binding site; inhibition site 315750003107 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 315750003108 B12 binding site [chemical binding]; other site 315750003109 cobalt ligand [ion binding]; other site 315750003110 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 315750003111 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 315750003112 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 315750003113 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 315750003114 FAD binding site [chemical binding]; other site 315750003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 315750003116 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 315750003117 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 315750003118 S1 domain; Region: S1_2; pfam13509 315750003119 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 315750003120 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 315750003121 ligand binding site [chemical binding]; other site 315750003122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750003123 dimerization interface [polypeptide binding]; other site 315750003124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750003125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750003126 dimer interface [polypeptide binding]; other site 315750003127 putative CheW interface [polypeptide binding]; other site 315750003128 EDD domain protein, DegV family; Region: DegV; TIGR00762 315750003129 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315750003130 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750003131 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750003132 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750003133 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315750003134 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 315750003135 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 315750003136 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750003137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 315750003138 motif II; other site 315750003139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 315750003140 esterase; Provisional; Region: PRK10566 315750003141 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315750003142 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 315750003143 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315750003144 FAD binding domain; Region: FAD_binding_4; pfam01565 315750003145 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 315750003146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003147 putative substrate translocation pore; other site 315750003148 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 315750003149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 315750003150 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 315750003151 heterotetramer interface [polypeptide binding]; other site 315750003152 active site pocket [active] 315750003153 cleavage site 315750003154 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 315750003155 nucleotide binding site [chemical binding]; other site 315750003156 N-acetyl-L-glutamate binding site [chemical binding]; other site 315750003157 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 315750003158 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750003159 inhibitor-cofactor binding pocket; inhibition site 315750003160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003161 catalytic residue [active] 315750003162 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 315750003163 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 315750003164 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 315750003165 catalytic site [active] 315750003166 subunit interface [polypeptide binding]; other site 315750003167 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 315750003168 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750003169 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 315750003170 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 315750003171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750003172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315750003173 ornithine carbamoyltransferase; Provisional; Region: PRK00779 315750003174 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315750003175 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 315750003176 YjzC-like protein; Region: YjzC; pfam14168 315750003177 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003179 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 315750003180 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315750003181 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 315750003182 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 315750003183 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 315750003184 putative ligand binding site [chemical binding]; other site 315750003185 ComZ; Region: ComZ; pfam10815 315750003186 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 315750003187 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 315750003188 dimer interface [polypeptide binding]; other site 315750003189 active site 315750003190 CoA binding pocket [chemical binding]; other site 315750003191 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 315750003192 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 315750003193 dimer interface [polypeptide binding]; other site 315750003194 active site 315750003195 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 315750003196 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750003198 Walker A/P-loop; other site 315750003199 ATP binding site [chemical binding]; other site 315750003200 Q-loop/lid; other site 315750003201 ABC transporter signature motif; other site 315750003202 Walker B; other site 315750003203 D-loop; other site 315750003204 H-loop/switch region; other site 315750003205 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315750003206 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 315750003207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750003208 Walker A/P-loop; other site 315750003209 ATP binding site [chemical binding]; other site 315750003210 Q-loop/lid; other site 315750003211 ABC transporter signature motif; other site 315750003212 Walker B; other site 315750003213 D-loop; other site 315750003214 H-loop/switch region; other site 315750003215 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315750003216 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315750003217 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 315750003218 peptide binding site [polypeptide binding]; other site 315750003219 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750003220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003221 dimer interface [polypeptide binding]; other site 315750003222 conserved gate region; other site 315750003223 putative PBP binding loops; other site 315750003224 ABC-ATPase subunit interface; other site 315750003225 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750003226 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003228 dimer interface [polypeptide binding]; other site 315750003229 conserved gate region; other site 315750003230 putative PBP binding loops; other site 315750003231 ABC-ATPase subunit interface; other site 315750003232 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315750003233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750003234 S-adenosylmethionine binding site [chemical binding]; other site 315750003235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003236 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750003237 putative substrate translocation pore; other site 315750003238 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 315750003239 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 315750003240 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 315750003241 active site 315750003242 HIGH motif; other site 315750003243 dimer interface [polypeptide binding]; other site 315750003244 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315750003245 KMSKS motif; other site 315750003246 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315750003247 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315750003248 peptide binding site [polypeptide binding]; other site 315750003249 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750003250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003251 dimer interface [polypeptide binding]; other site 315750003252 conserved gate region; other site 315750003253 putative PBP binding loops; other site 315750003254 ABC-ATPase subunit interface; other site 315750003255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750003256 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750003257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003258 dimer interface [polypeptide binding]; other site 315750003259 conserved gate region; other site 315750003260 putative PBP binding loops; other site 315750003261 ABC-ATPase subunit interface; other site 315750003262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750003264 Walker A/P-loop; other site 315750003265 ATP binding site [chemical binding]; other site 315750003266 Q-loop/lid; other site 315750003267 ABC transporter signature motif; other site 315750003268 Walker B; other site 315750003269 D-loop; other site 315750003270 H-loop/switch region; other site 315750003271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750003274 Walker A/P-loop; other site 315750003275 ATP binding site [chemical binding]; other site 315750003276 Q-loop/lid; other site 315750003277 ABC transporter signature motif; other site 315750003278 Walker B; other site 315750003279 D-loop; other site 315750003280 H-loop/switch region; other site 315750003281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003282 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 315750003283 ArsC family; Region: ArsC; pfam03960 315750003284 putative catalytic residues [active] 315750003285 thiol/disulfide switch; other site 315750003286 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 315750003287 adaptor protein; Provisional; Region: PRK02315 315750003288 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 315750003289 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315750003290 putative active site [active] 315750003291 catalytic site [active] 315750003292 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315750003293 putative active site [active] 315750003294 catalytic site [active] 315750003295 Competence protein CoiA-like family; Region: CoiA; cl11541 315750003296 oligoendopeptidase F; Region: pepF; TIGR00181 315750003297 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 315750003298 active site 315750003299 Zn binding site [ion binding]; other site 315750003300 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315750003301 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315750003302 catalytic residues [active] 315750003303 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 315750003304 apolar tunnel; other site 315750003305 heme binding site [chemical binding]; other site 315750003306 dimerization interface [polypeptide binding]; other site 315750003307 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 315750003308 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315750003309 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750003310 catalytic residue [active] 315750003311 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 315750003312 putative active site [active] 315750003313 putative metal binding residues [ion binding]; other site 315750003314 signature motif; other site 315750003315 putative triphosphate binding site [ion binding]; other site 315750003316 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315750003317 synthetase active site [active] 315750003318 NTP binding site [chemical binding]; other site 315750003319 metal binding site [ion binding]; metal-binding site 315750003320 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 315750003321 ATP-NAD kinase; Region: NAD_kinase; pfam01513 315750003322 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315750003323 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315750003324 active site 315750003325 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 315750003326 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315750003327 active site 315750003328 metal binding site [ion binding]; metal-binding site 315750003329 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 315750003330 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315750003331 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315750003332 TrkA-N domain; Region: TrkA_N; pfam02254 315750003333 TrkA-C domain; Region: TrkA_C; pfam02080 315750003334 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 315750003335 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315750003336 thiamine phosphate binding site [chemical binding]; other site 315750003337 active site 315750003338 pyrophosphate binding site [ion binding]; other site 315750003339 hydroxyglutarate oxidase; Provisional; Region: PRK11728 315750003340 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 315750003341 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 315750003342 thiS-thiF/thiG interaction site; other site 315750003343 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 315750003344 ThiS interaction site; other site 315750003345 putative active site [active] 315750003346 tetramer interface [polypeptide binding]; other site 315750003347 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 315750003348 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315750003349 ATP binding site [chemical binding]; other site 315750003350 substrate interface [chemical binding]; other site 315750003351 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315750003352 dimer interface [polypeptide binding]; other site 315750003353 substrate binding site [chemical binding]; other site 315750003354 ATP binding site [chemical binding]; other site 315750003355 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 315750003356 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 315750003357 NAD binding site [chemical binding]; other site 315750003358 homotetramer interface [polypeptide binding]; other site 315750003359 homodimer interface [polypeptide binding]; other site 315750003360 substrate binding site [chemical binding]; other site 315750003361 active site 315750003362 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 315750003363 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315750003364 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315750003365 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 315750003366 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 315750003367 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 315750003368 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 315750003369 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 315750003370 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 315750003371 Part of AAA domain; Region: AAA_19; pfam13245 315750003372 Family description; Region: UvrD_C_2; pfam13538 315750003373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003374 Coenzyme A binding pocket [chemical binding]; other site 315750003375 hypothetical protein; Provisional; Region: PRK13679 315750003376 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315750003377 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 315750003378 Putative esterase; Region: Esterase; pfam00756 315750003379 cystathionine gamma-synthase; Reviewed; Region: PRK08247 315750003380 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750003381 homodimer interface [polypeptide binding]; other site 315750003382 substrate-cofactor binding pocket; other site 315750003383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003384 catalytic residue [active] 315750003385 cystathionine beta-lyase; Provisional; Region: PRK08064 315750003386 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750003387 homodimer interface [polypeptide binding]; other site 315750003388 substrate-cofactor binding pocket; other site 315750003389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003390 catalytic residue [active] 315750003391 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315750003392 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750003393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750003394 dimerization interface [polypeptide binding]; other site 315750003395 putative DNA binding site [nucleotide binding]; other site 315750003396 putative Zn2+ binding site [ion binding]; other site 315750003397 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750003398 homotrimer interaction site [polypeptide binding]; other site 315750003399 putative active site [active] 315750003400 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315750003401 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 315750003402 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003403 MarR family; Region: MarR_2; pfam12802 315750003404 Domain of unknown function (DUF303); Region: DUF303; pfam03629 315750003405 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 315750003406 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 315750003407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750003408 binding surface 315750003409 TPR motif; other site 315750003410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003411 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003412 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315750003413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750003415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750003416 dimerization interface [polypeptide binding]; other site 315750003417 aspartate racemase; Region: asp_race; TIGR00035 315750003418 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315750003419 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750003420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750003421 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750003423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750003424 dimerization interface [polypeptide binding]; other site 315750003425 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 315750003426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003427 putative substrate translocation pore; other site 315750003428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750003429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003430 Coenzyme A binding pocket [chemical binding]; other site 315750003431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750003432 binding surface 315750003433 TPR motif; other site 315750003434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003435 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750003436 alanine racemase; Region: alr; TIGR00492 315750003437 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315750003438 active site 315750003439 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750003440 dimer interface [polypeptide binding]; other site 315750003441 substrate binding site [chemical binding]; other site 315750003442 catalytic residues [active] 315750003443 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 315750003444 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 315750003445 catalytic Zn binding site [ion binding]; other site 315750003446 NAD binding site [chemical binding]; other site 315750003447 structural Zn binding site [ion binding]; other site 315750003448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750003449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750003450 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315750003451 flagellin; Provisional; Region: PRK12804 315750003452 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003453 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003454 flagellin; Provisional; Region: PRK12804 315750003455 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003456 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003457 flagellin; Provisional; Region: PRK12804 315750003458 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003459 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003460 flagellin; Provisional; Region: PRK12804 315750003461 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003462 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003463 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 315750003464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750003465 dimer interface [polypeptide binding]; other site 315750003466 putative CheW interface [polypeptide binding]; other site 315750003467 Protein of unknown function (DUF867); Region: DUF867; pfam05908 315750003468 Domain of unknown function (DUF955); Region: DUF955; pfam06114 315750003469 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 315750003470 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315750003471 amidase catalytic site [active] 315750003472 Zn binding residues [ion binding]; other site 315750003473 substrate binding site [chemical binding]; other site 315750003474 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750003475 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 315750003476 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315750003477 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 315750003478 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 315750003479 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 315750003480 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 315750003481 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 315750003482 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 315750003483 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 315750003484 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750003485 active site 315750003486 phosphorylation site [posttranslational modification] 315750003487 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 315750003488 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 315750003489 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 315750003490 active site 315750003491 P-loop; other site 315750003492 phosphorylation site [posttranslational modification] 315750003493 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315750003494 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 315750003495 putative NAD(P) binding site [chemical binding]; other site 315750003496 catalytic Zn binding site [ion binding]; other site 315750003497 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 315750003498 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750003499 tetramer interface [polypeptide binding]; other site 315750003500 TPP-binding site [chemical binding]; other site 315750003501 heterodimer interface [polypeptide binding]; other site 315750003502 phosphorylation loop region [posttranslational modification] 315750003503 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750003504 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750003505 alpha subunit interface [polypeptide binding]; other site 315750003506 TPP binding site [chemical binding]; other site 315750003507 heterodimer interface [polypeptide binding]; other site 315750003508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750003509 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750003510 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750003511 E3 interaction surface; other site 315750003512 lipoyl attachment site [posttranslational modification]; other site 315750003513 e3 binding domain; Region: E3_binding; pfam02817 315750003514 e3 binding domain; Region: E3_binding; pfam02817 315750003515 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315750003516 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 315750003517 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 315750003518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750003519 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750003520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750003522 NAD(P) binding site [chemical binding]; other site 315750003523 active site 315750003524 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 315750003525 classical (c) SDRs; Region: SDR_c; cd05233 315750003526 NAD(P) binding site [chemical binding]; other site 315750003527 active site 315750003528 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750003529 Helix-turn-helix domain; Region: HTH_38; pfam13936 315750003530 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750003531 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 315750003532 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315750003533 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750003534 Zn binding site [ion binding]; other site 315750003535 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315750003536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750003537 Zn binding site [ion binding]; other site 315750003538 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315750003539 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 315750003540 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750003541 protein binding site [polypeptide binding]; other site 315750003542 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 315750003543 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315750003544 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 315750003545 SxDxEG motif; other site 315750003546 active site 315750003547 metal binding site [ion binding]; metal-binding site 315750003548 homopentamer interface [polypeptide binding]; other site 315750003549 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750003550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003551 dimer interface [polypeptide binding]; other site 315750003552 conserved gate region; other site 315750003553 putative PBP binding loops; other site 315750003554 ABC-ATPase subunit interface; other site 315750003555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750003556 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750003557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003558 putative PBP binding loops; other site 315750003559 dimer interface [polypeptide binding]; other site 315750003560 ABC-ATPase subunit interface; other site 315750003561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750003563 Walker A/P-loop; other site 315750003564 ATP binding site [chemical binding]; other site 315750003565 Q-loop/lid; other site 315750003566 ABC transporter signature motif; other site 315750003567 Walker B; other site 315750003568 D-loop; other site 315750003569 H-loop/switch region; other site 315750003570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003571 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315750003572 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315750003573 peptide binding site [polypeptide binding]; other site 315750003574 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 315750003575 dimer interface [polypeptide binding]; other site 315750003576 catalytic triad [active] 315750003577 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 315750003578 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 315750003579 active site 315750003580 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750003581 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750003582 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 315750003583 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750003584 Walker A/P-loop; other site 315750003585 ATP binding site [chemical binding]; other site 315750003586 Q-loop/lid; other site 315750003587 ABC transporter signature motif; other site 315750003588 Walker B; other site 315750003589 D-loop; other site 315750003590 H-loop/switch region; other site 315750003591 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315750003592 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 315750003593 Amidinotransferase; Region: Amidinotransf; pfam02274 315750003594 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 315750003595 Predicted transcriptional regulators [Transcription]; Region: COG1695 315750003596 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315750003597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750003598 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 315750003599 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 315750003600 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 315750003601 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315750003602 DNA binding site [nucleotide binding] 315750003603 active site 315750003604 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315750003605 possible YkkC-YxkD riboswitch; BPUM_nc0009 315750003606 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315750003607 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315750003608 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 315750003609 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 315750003610 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 315750003611 putative active site [active] 315750003612 putative substrate binding site [chemical binding]; other site 315750003613 putative cosubstrate binding site; other site 315750003614 catalytic site [active] 315750003615 gamma-glutamyl kinase; Provisional; Region: PRK05429 315750003616 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 315750003617 nucleotide binding site [chemical binding]; other site 315750003618 homotetrameric interface [polypeptide binding]; other site 315750003619 putative phosphate binding site [ion binding]; other site 315750003620 putative allosteric binding site; other site 315750003621 PUA domain; Region: PUA; pfam01472 315750003622 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 315750003623 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 315750003624 putative catalytic cysteine [active] 315750003625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750003626 binding surface 315750003627 TPR motif; other site 315750003628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750003629 TPR motif; other site 315750003630 binding surface 315750003631 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003632 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 315750003633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003634 MarR family; Region: MarR; pfam01047 315750003635 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 315750003636 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 315750003637 nucleoside/Zn binding site; other site 315750003638 dimer interface [polypeptide binding]; other site 315750003639 catalytic motif [active] 315750003640 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 315750003641 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 315750003642 THF binding site; other site 315750003643 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 315750003644 substrate binding site [chemical binding]; other site 315750003645 THF binding site; other site 315750003646 zinc-binding site [ion binding]; other site 315750003647 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315750003648 active site 315750003649 catalytic residues [active] 315750003650 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750003651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750003652 active site 315750003653 phosphorylation site [posttranslational modification] 315750003654 intermolecular recognition site; other site 315750003655 dimerization interface [polypeptide binding]; other site 315750003656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750003657 DNA binding site [nucleotide binding] 315750003658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750003659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750003660 dimerization interface [polypeptide binding]; other site 315750003661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003662 dimer interface [polypeptide binding]; other site 315750003663 phosphorylation site [posttranslational modification] 315750003664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003665 ATP binding site [chemical binding]; other site 315750003666 Mg2+ binding site [ion binding]; other site 315750003667 G-X-G motif; other site 315750003668 Predicted membrane protein [Function unknown]; Region: COG3212 315750003669 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315750003670 Predicted membrane protein [Function unknown]; Region: COG3212 315750003671 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315750003672 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315750003673 YkoK riboswitch; BPUM_nc0010 315750003674 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 315750003675 MgtE intracellular N domain; Region: MgtE_N; smart00924 315750003676 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 315750003677 Divalent cation transporter; Region: MgtE; pfam01769 315750003678 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 315750003679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750003681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750003682 dimerization interface [polypeptide binding]; other site 315750003683 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 315750003684 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 315750003685 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315750003686 DNA binding residues [nucleotide binding] 315750003687 putative dimer interface [polypeptide binding]; other site 315750003688 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003689 MarR family; Region: MarR; pfam01047 315750003690 MarR family; Region: MarR_2; cl17246 315750003691 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 315750003692 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 315750003693 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 315750003694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315750003695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750003696 metal binding site [ion binding]; metal-binding site 315750003697 active site 315750003698 I-site; other site 315750003699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315750003700 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315750003701 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315750003702 YybP-YkoY riboswitch element; SraF riboswitch; BPUM_nc0011 315750003703 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 315750003704 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 315750003705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750003706 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 315750003707 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750003708 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 315750003709 heat shock protein HtpX; Provisional; Region: PRK05457 315750003710 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 315750003711 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315750003712 Predicted membrane protein [Function unknown]; Region: COG2323 315750003713 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 315750003714 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750003715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003716 PAS domain; Region: PAS_9; pfam13426 315750003717 putative active site [active] 315750003718 heme pocket [chemical binding]; other site 315750003719 PAS domain S-box; Region: sensory_box; TIGR00229 315750003720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003721 putative active site [active] 315750003722 heme pocket [chemical binding]; other site 315750003723 PAS domain S-box; Region: sensory_box; TIGR00229 315750003724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003725 putative active site [active] 315750003726 heme pocket [chemical binding]; other site 315750003727 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315750003728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003729 putative active site [active] 315750003730 heme pocket [chemical binding]; other site 315750003731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003732 dimer interface [polypeptide binding]; other site 315750003733 phosphorylation site [posttranslational modification] 315750003734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003735 ATP binding site [chemical binding]; other site 315750003736 Mg2+ binding site [ion binding]; other site 315750003737 G-X-G motif; other site 315750003738 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 315750003739 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 315750003740 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315750003741 DNA binding site [nucleotide binding] 315750003742 active site 315750003743 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 315750003744 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 315750003745 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315750003746 transaminase; Reviewed; Region: PRK08068 315750003747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750003748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003749 homodimer interface [polypeptide binding]; other site 315750003750 catalytic residue [active] 315750003751 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 315750003752 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 315750003753 dimer interface [polypeptide binding]; other site 315750003754 active site 315750003755 catalytic residue [active] 315750003756 metal binding site [ion binding]; metal-binding site 315750003757 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 315750003758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750003759 motif II; other site 315750003760 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 315750003761 intersubunit interface [polypeptide binding]; other site 315750003762 active site 315750003763 Zn2+ binding site [ion binding]; other site 315750003764 ARD/ARD' family; Region: ARD; pfam03079 315750003765 Cupin domain; Region: Cupin_2; pfam07883 315750003766 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315750003767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003768 dimer interface [polypeptide binding]; other site 315750003769 phosphorylation site [posttranslational modification] 315750003770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003771 ATP binding site [chemical binding]; other site 315750003772 Mg2+ binding site [ion binding]; other site 315750003773 G-X-G motif; other site 315750003774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003775 MarR family; Region: MarR; pfam01047 315750003776 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 315750003777 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 315750003778 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 315750003779 ligand binding site [chemical binding]; other site 315750003780 flagellar motor protein MotA; Validated; Region: PRK08124 315750003781 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315750003782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750003783 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315750003784 Walker A motif; other site 315750003785 ATP binding site [chemical binding]; other site 315750003786 Walker B motif; other site 315750003787 arginine finger; other site 315750003788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750003789 Walker A motif; other site 315750003790 ATP binding site [chemical binding]; other site 315750003791 Walker B motif; other site 315750003792 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315750003793 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 315750003794 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 315750003795 Ligand Binding Site [chemical binding]; other site 315750003796 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 315750003797 active site 315750003798 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 315750003799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750003800 FeS/SAM binding site; other site 315750003801 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 315750003802 putative acetyltransferase YhhY; Provisional; Region: PRK10140 315750003803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003804 Coenzyme A binding pocket [chemical binding]; other site 315750003805 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 315750003806 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315750003807 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315750003808 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750003809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315750003810 catalytic residues [active] 315750003811 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 315750003812 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750003813 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315750003814 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315750003815 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315750003816 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315750003817 active site 315750003818 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750003819 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750003820 DNA binding site [nucleotide binding] 315750003821 domain linker motif; other site 315750003822 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315750003823 putative dimerization interface [polypeptide binding]; other site 315750003824 putative ligand binding site [chemical binding]; other site 315750003825 CAT RNA binding domain; Region: CAT_RBD; smart01061 315750003826 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750003827 PRD domain; Region: PRD; pfam00874 315750003828 PRD domain; Region: PRD; pfam00874 315750003829 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750003830 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 315750003831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750003832 active site turn [active] 315750003833 phosphorylation site [posttranslational modification] 315750003834 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315750003835 HPr interaction site; other site 315750003836 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750003837 active site 315750003838 phosphorylation site [posttranslational modification] 315750003839 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315750003840 dimerization domain swap beta strand [polypeptide binding]; other site 315750003841 regulatory protein interface [polypeptide binding]; other site 315750003842 active site 315750003843 regulatory phosphorylation site [posttranslational modification]; other site 315750003844 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 315750003845 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 315750003846 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 315750003847 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 315750003848 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 315750003849 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 315750003850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750003851 FeS/SAM binding site; other site 315750003852 Cache domain; Region: Cache_1; pfam02743 315750003853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750003854 dimerization interface [polypeptide binding]; other site 315750003855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750003856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750003857 dimer interface [polypeptide binding]; other site 315750003858 putative CheW interface [polypeptide binding]; other site 315750003859 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750003860 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 315750003861 putative NAD(P) binding site [chemical binding]; other site 315750003862 putative active site [active] 315750003863 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315750003864 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315750003865 Transposase domain (DUF772); Region: DUF772; pfam05598 315750003866 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750003867 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750003868 PCI domain; Region: PCI; cl02111 315750003869 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315750003870 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315750003871 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750003872 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750003873 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750003874 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750003875 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 315750003876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003877 putative active site [active] 315750003878 heme pocket [chemical binding]; other site 315750003879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003880 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 315750003881 putative active site [active] 315750003882 heme pocket [chemical binding]; other site 315750003883 PAS domain; Region: PAS; smart00091 315750003884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315750003885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003886 dimer interface [polypeptide binding]; other site 315750003887 phosphorylation site [posttranslational modification] 315750003888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003889 ATP binding site [chemical binding]; other site 315750003890 Mg2+ binding site [ion binding]; other site 315750003891 G-X-G motif; other site 315750003892 aminotransferase A; Validated; Region: PRK07683 315750003893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750003894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003895 homodimer interface [polypeptide binding]; other site 315750003896 catalytic residue [active] 315750003897 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315750003898 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 315750003899 RDD family; Region: RDD; pfam06271 315750003900 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 315750003901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003902 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 315750003903 putative CheA interaction surface; other site 315750003904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750003905 Response regulator receiver domain; Region: Response_reg; pfam00072 315750003906 active site 315750003907 phosphorylation site [posttranslational modification] 315750003908 intermolecular recognition site; other site 315750003909 dimerization interface [polypeptide binding]; other site 315750003910 YkyB-like protein; Region: YkyB; pfam14177 315750003911 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750003912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003913 putative substrate translocation pore; other site 315750003914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750003915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 315750003916 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 315750003917 phosphodiesterase YaeI; Provisional; Region: PRK11340 315750003918 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 315750003919 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315750003920 putative active site [active] 315750003921 putative metal binding site [ion binding]; other site 315750003922 short chain dehydrogenase; Provisional; Region: PRK07677 315750003923 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 315750003924 NAD(P) binding site [chemical binding]; other site 315750003925 substrate binding site [chemical binding]; other site 315750003926 homotetramer interface [polypeptide binding]; other site 315750003927 active site 315750003928 homodimer interface [polypeptide binding]; other site 315750003929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315750003930 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 315750003931 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 315750003932 dimanganese center [ion binding]; other site 315750003933 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 315750003934 Protein of unknown function (DUF458); Region: DUF458; pfam04308 315750003935 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 315750003936 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 315750003937 FOG: CBS domain [General function prediction only]; Region: COG0517 315750003938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750003940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750003941 dimerization interface [polypeptide binding]; other site 315750003942 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 315750003943 flavodoxin; Provisional; Region: PRK06703 315750003944 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 315750003945 flavodoxin, short chain; Region: flav_short; TIGR01753 315750003946 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 315750003947 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 315750003948 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 315750003949 active site 315750003950 trimer interface [polypeptide binding]; other site 315750003951 substrate binding site [chemical binding]; other site 315750003952 CoA binding site [chemical binding]; other site 315750003953 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315750003954 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 315750003955 metal binding site [ion binding]; metal-binding site 315750003956 putative dimer interface [polypeptide binding]; other site 315750003957 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 315750003958 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 315750003959 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315750003960 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 315750003961 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 315750003962 dimer interface [polypeptide binding]; other site 315750003963 decamer (pentamer of dimers) interface [polypeptide binding]; other site 315750003964 catalytic triad [active] 315750003965 peroxidatic and resolving cysteines [active] 315750003966 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750003967 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315750003968 catalytic residues [active] 315750003969 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 315750003970 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 315750003971 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 315750003972 GTP binding site; other site 315750003973 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 315750003974 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315750003975 ATP binding site [chemical binding]; other site 315750003976 substrate interface [chemical binding]; other site 315750003977 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 315750003978 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 315750003979 dimer interface [polypeptide binding]; other site 315750003980 putative functional site; other site 315750003981 putative MPT binding site; other site 315750003982 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315750003983 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 315750003984 MoaE homodimer interface [polypeptide binding]; other site 315750003985 MoaD interaction [polypeptide binding]; other site 315750003986 active site residues [active] 315750003987 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 315750003988 MoaE interaction surface [polypeptide binding]; other site 315750003989 MoeB interaction surface [polypeptide binding]; other site 315750003990 thiocarboxylated glycine; other site 315750003991 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 315750003992 HlyD family secretion protein; Region: HlyD_3; pfam13437 315750003993 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750003994 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315750003995 Walker A/P-loop; other site 315750003996 ATP binding site [chemical binding]; other site 315750003997 Q-loop/lid; other site 315750003998 ABC transporter signature motif; other site 315750003999 Walker B; other site 315750004000 D-loop; other site 315750004001 H-loop/switch region; other site 315750004002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315750004003 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315750004004 FtsX-like permease family; Region: FtsX; pfam02687 315750004005 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315750004006 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 315750004007 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 315750004008 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 315750004009 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 315750004010 putative substrate binding site [chemical binding]; other site 315750004011 putative ATP binding site [chemical binding]; other site 315750004012 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 315750004013 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750004014 active site 315750004015 phosphorylation site [posttranslational modification] 315750004016 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315750004017 active site 315750004018 P-loop; other site 315750004019 phosphorylation site [posttranslational modification] 315750004020 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 315750004021 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315750004022 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315750004023 Catalytic site [active] 315750004024 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 315750004025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750004026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750004027 ABC transporter; Region: ABC_tran_2; pfam12848 315750004028 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750004029 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 315750004030 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 315750004031 rod-share determining protein MreBH; Provisional; Region: PRK13929 315750004032 MreB and similar proteins; Region: MreB_like; cd10225 315750004033 nucleotide binding site [chemical binding]; other site 315750004034 Mg binding site [ion binding]; other site 315750004035 putative protofilament interaction site [polypeptide binding]; other site 315750004036 RodZ interaction site [polypeptide binding]; other site 315750004037 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 315750004038 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315750004039 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315750004040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750004041 putative active site [active] 315750004042 heme pocket [chemical binding]; other site 315750004043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750004044 dimer interface [polypeptide binding]; other site 315750004045 phosphorylation site [posttranslational modification] 315750004046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750004047 ATP binding site [chemical binding]; other site 315750004048 Mg2+ binding site [ion binding]; other site 315750004049 G-X-G motif; other site 315750004050 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 315750004051 putative active site pocket [active] 315750004052 dimerization interface [polypeptide binding]; other site 315750004053 putative catalytic residue [active] 315750004054 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 315750004055 putative active site pocket [active] 315750004056 dimerization interface [polypeptide binding]; other site 315750004057 putative catalytic residue [active] 315750004058 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315750004059 TrkA-N domain; Region: TrkA_N; pfam02254 315750004060 TrkA-C domain; Region: TrkA_C; pfam02080 315750004061 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 315750004062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750004063 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 315750004064 active site 315750004065 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 315750004066 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315750004067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 315750004068 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315750004069 hypothetical protein; Provisional; Region: PRK13667 315750004070 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 315750004071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750004072 active site 315750004073 motif I; other site 315750004074 motif II; other site 315750004075 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315750004076 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315750004077 active site 315750004078 catalytic residues [active] 315750004079 metal binding site [ion binding]; metal-binding site 315750004080 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315750004081 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 315750004082 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750004083 TPP-binding site [chemical binding]; other site 315750004084 tetramer interface [polypeptide binding]; other site 315750004085 heterodimer interface [polypeptide binding]; other site 315750004086 phosphorylation loop region [posttranslational modification] 315750004087 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750004088 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750004089 alpha subunit interface [polypeptide binding]; other site 315750004090 TPP binding site [chemical binding]; other site 315750004091 heterodimer interface [polypeptide binding]; other site 315750004092 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750004093 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750004094 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750004095 E3 interaction surface; other site 315750004096 lipoyl attachment site [posttranslational modification]; other site 315750004097 e3 binding domain; Region: E3_binding; pfam02817 315750004098 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315750004099 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 315750004100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315750004101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750004102 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750004103 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315750004104 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 315750004105 homodimer interface [polypeptide binding]; other site 315750004106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750004107 catalytic residue [active] 315750004108 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315750004109 hypothetical protein; Provisional; Region: PRK04387 315750004110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 315750004111 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 315750004112 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 315750004113 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 315750004114 active site 315750004115 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 315750004116 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 315750004117 G1 box; other site 315750004118 putative GEF interaction site [polypeptide binding]; other site 315750004119 GTP/Mg2+ binding site [chemical binding]; other site 315750004120 Switch I region; other site 315750004121 G2 box; other site 315750004122 G3 box; other site 315750004123 Switch II region; other site 315750004124 G4 box; other site 315750004125 G5 box; other site 315750004126 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 315750004127 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 315750004128 YlaH-like protein; Region: YlaH; pfam14036 315750004129 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 315750004130 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 315750004131 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750004132 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 315750004133 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 315750004134 putative active site [active] 315750004135 PhoH-like protein; Region: PhoH; pfam02562 315750004136 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 315750004137 glutaminase A; Region: Gln_ase; TIGR03814 315750004138 hypothetical protein; Provisional; Region: PRK13666 315750004139 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 315750004140 pyruvate carboxylase; Reviewed; Region: PRK12999 315750004141 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750004142 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 315750004143 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 315750004144 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 315750004145 active site 315750004146 catalytic residues [active] 315750004147 metal binding site [ion binding]; metal-binding site 315750004148 homodimer binding site [polypeptide binding]; other site 315750004149 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315750004150 carboxyltransferase (CT) interaction site; other site 315750004151 biotinylation site [posttranslational modification]; other site 315750004152 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 315750004153 DNA photolyase; Region: DNA_photolyase; pfam00875 315750004154 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 315750004155 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 315750004156 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 315750004157 UbiA prenyltransferase family; Region: UbiA; pfam01040 315750004158 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 315750004159 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 315750004160 Cytochrome c; Region: Cytochrom_C; pfam00034 315750004161 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315750004162 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315750004163 D-pathway; other site 315750004164 Putative ubiquinol binding site [chemical binding]; other site 315750004165 Low-spin heme (heme b) binding site [chemical binding]; other site 315750004166 Putative water exit pathway; other site 315750004167 Binuclear center (heme o3/CuB) [ion binding]; other site 315750004168 K-pathway; other site 315750004169 Putative proton exit pathway; other site 315750004170 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315750004171 Subunit I/III interface [polypeptide binding]; other site 315750004172 Subunit III/IV interface [polypeptide binding]; other site 315750004173 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 315750004174 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 315750004175 YugN-like family; Region: YugN; pfam08868 315750004176 FOG: CBS domain [General function prediction only]; Region: COG0517 315750004177 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 315750004178 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315750004179 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315750004180 Putative coat protein; Region: YlbD_coat; pfam14071 315750004181 YlbE-like protein; Region: YlbE; pfam14003 315750004182 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 315750004183 hypothetical protein; Provisional; Region: PRK02886 315750004184 BPUM_nc0013; possible ylbH leader 315750004185 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 315750004186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750004187 S-adenosylmethionine binding site [chemical binding]; other site 315750004188 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 315750004189 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 315750004190 active site 315750004191 (T/H)XGH motif; other site 315750004192 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 315750004193 Nucleoside recognition; Region: Gate; pfam07670 315750004194 Nucleoside recognition; Region: Gate; pfam07670 315750004195 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315750004196 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 315750004197 active site 315750004198 nucleophile elbow; other site 315750004199 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 315750004200 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 315750004201 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 315750004202 protein binding site [polypeptide binding]; other site 315750004203 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 315750004204 hypothetical protein; Provisional; Region: PRK13670 315750004205 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 315750004206 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 315750004207 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 315750004208 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315750004209 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315750004210 hypothetical protein; Provisional; Region: PRK13688 315750004211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750004212 Coenzyme A binding pocket [chemical binding]; other site 315750004213 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 315750004214 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 315750004215 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 315750004216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 315750004217 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 315750004218 MraZ protein; Region: MraZ; pfam02381 315750004219 MraZ protein; Region: MraZ; pfam02381 315750004220 MraW methylase family; Region: Methyltransf_5; pfam01795 315750004221 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 315750004222 Cell division protein FtsL; Region: FtsL; cl11433 315750004223 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750004224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750004225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750004226 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 315750004227 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 315750004228 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 315750004229 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750004230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750004231 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 315750004232 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 315750004233 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315750004234 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750004235 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750004236 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 315750004237 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 315750004238 Mg++ binding site [ion binding]; other site 315750004239 putative catalytic motif [active] 315750004240 putative substrate binding site [chemical binding]; other site 315750004241 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 315750004242 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750004243 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750004244 stage V sporulation protein E; Region: spoVE; TIGR02615 315750004245 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 315750004246 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315750004247 active site 315750004248 homodimer interface [polypeptide binding]; other site 315750004249 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 315750004250 FAD binding domain; Region: FAD_binding_4; pfam01565 315750004251 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 315750004252 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 315750004253 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 315750004254 Cell division protein FtsQ; Region: FtsQ; pfam03799 315750004255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 315750004256 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 315750004257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 315750004258 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 315750004259 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 315750004260 cell division protein FtsA; Region: ftsA; TIGR01174 315750004261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750004262 nucleotide binding site [chemical binding]; other site 315750004263 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 315750004264 Cell division protein FtsA; Region: FtsA; pfam14450 315750004265 cell division protein FtsZ; Validated; Region: PRK09330 315750004266 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 315750004267 nucleotide binding site [chemical binding]; other site 315750004268 SulA interaction site; other site 315750004269 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315750004270 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 315750004271 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 315750004272 active site 315750004273 catalytic triad [active] 315750004274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315750004275 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 315750004276 Cna protein B-type domain; Region: Cna_B_2; pfam13715 315750004277 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 315750004278 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 315750004279 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 315750004280 sporulation sigma factor SigE; Reviewed; Region: PRK08301 315750004281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750004282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750004283 DNA binding residues [nucleotide binding] 315750004284 sporulation sigma factor SigG; Reviewed; Region: PRK08215 315750004285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750004286 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750004287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750004288 DNA binding residues [nucleotide binding] 315750004289 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750004290 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750004291 putative DNA binding site [nucleotide binding]; other site 315750004292 putative Zn2+ binding site [ion binding]; other site 315750004293 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750004294 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 315750004295 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315750004296 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 315750004297 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 315750004298 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 315750004299 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 315750004300 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 315750004301 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 315750004302 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 315750004303 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750004304 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750004305 Walker A/P-loop; other site 315750004306 ATP binding site [chemical binding]; other site 315750004307 Q-loop/lid; other site 315750004308 ABC transporter signature motif; other site 315750004309 Walker B; other site 315750004310 D-loop; other site 315750004311 H-loop/switch region; other site 315750004312 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 315750004313 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 315750004314 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 315750004315 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 315750004316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750004317 catalytic residue [active] 315750004318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 315750004319 YGGT family; Region: YGGT; pfam02325 315750004320 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 315750004321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750004322 RNA binding surface [nucleotide binding]; other site 315750004323 DivIVA protein; Region: DivIVA; pfam05103 315750004324 DivIVA domain; Region: DivI1A_domain; TIGR03544 315750004325 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 315750004326 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315750004327 HIGH motif; other site 315750004328 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315750004329 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315750004330 active site 315750004331 KMSKS motif; other site 315750004332 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 315750004333 tRNA binding surface [nucleotide binding]; other site 315750004334 anticodon binding site; other site 315750004335 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315750004336 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 315750004337 lipoprotein signal peptidase; Provisional; Region: PRK14787 315750004338 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 315750004339 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750004340 RNA binding surface [nucleotide binding]; other site 315750004341 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315750004342 active site 315750004343 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 315750004344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750004345 active site 315750004346 uracil transporter; Provisional; Region: PRK10720 315750004347 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 315750004348 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315750004349 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 315750004350 dihydroorotase; Validated; Region: pyrC; PRK09357 315750004351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750004352 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 315750004353 active site 315750004354 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 315750004355 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 315750004356 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 315750004357 catalytic site [active] 315750004358 subunit interface [polypeptide binding]; other site 315750004359 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 315750004360 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750004361 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 315750004362 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 315750004363 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750004364 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315750004365 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 315750004366 IMP binding site; other site 315750004367 dimer interface [polypeptide binding]; other site 315750004368 interdomain contacts; other site 315750004369 partial ornithine binding site; other site 315750004370 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 315750004371 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 315750004372 FAD binding pocket [chemical binding]; other site 315750004373 FAD binding motif [chemical binding]; other site 315750004374 phosphate binding motif [ion binding]; other site 315750004375 beta-alpha-beta structure motif; other site 315750004376 NAD binding pocket [chemical binding]; other site 315750004377 Iron coordination center [ion binding]; other site 315750004378 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 315750004379 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 315750004380 heterodimer interface [polypeptide binding]; other site 315750004381 active site 315750004382 FMN binding site [chemical binding]; other site 315750004383 homodimer interface [polypeptide binding]; other site 315750004384 substrate binding site [chemical binding]; other site 315750004385 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 315750004386 active site 315750004387 dimer interface [polypeptide binding]; other site 315750004388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750004389 active site 315750004390 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 315750004391 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 315750004392 Active Sites [active] 315750004393 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 315750004394 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 315750004395 ATP-sulfurylase; Region: ATPS; cd00517 315750004396 active site 315750004397 HXXH motif; other site 315750004398 flexible loop; other site 315750004399 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 315750004400 AAA domain; Region: AAA_18; pfam13238 315750004401 ligand-binding site [chemical binding]; other site 315750004402 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 315750004403 active site 315750004404 SAM binding site [chemical binding]; other site 315750004405 homodimer interface [polypeptide binding]; other site 315750004406 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 315750004407 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 315750004408 putative active site [active] 315750004409 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 315750004410 putative active site [active] 315750004411 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 315750004412 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 315750004413 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 315750004414 Domain of unknown function (DUF814); Region: DUF814; pfam05670 315750004415 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 315750004416 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 315750004417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750004418 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315750004419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750004420 motif II; other site 315750004421 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315750004422 hypothetical protein; Provisional; Region: PRK11820 315750004423 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 315750004424 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 315750004425 hypothetical protein; Provisional; Region: PRK04323 315750004426 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 315750004427 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 315750004428 catalytic site [active] 315750004429 G-X2-G-X-G-K; other site 315750004430 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 315750004431 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 315750004432 Flavoprotein; Region: Flavoprotein; pfam02441 315750004433 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 315750004434 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 315750004435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750004436 ATP binding site [chemical binding]; other site 315750004437 putative Mg++ binding site [ion binding]; other site 315750004438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750004439 nucleotide binding region [chemical binding]; other site 315750004440 ATP-binding site [chemical binding]; other site 315750004441 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315750004442 active site 315750004443 catalytic residues [active] 315750004444 metal binding site [ion binding]; metal-binding site 315750004445 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 315750004446 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 315750004447 putative active site [active] 315750004448 substrate binding site [chemical binding]; other site 315750004449 putative cosubstrate binding site; other site 315750004450 catalytic site [active] 315750004451 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 315750004452 substrate binding site [chemical binding]; other site 315750004453 16S rRNA methyltransferase B; Provisional; Region: PRK14902 315750004454 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 315750004455 putative RNA binding site [nucleotide binding]; other site 315750004456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750004457 S-adenosylmethionine binding site [chemical binding]; other site 315750004458 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 315750004459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750004460 FeS/SAM binding site; other site 315750004461 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 315750004462 Protein phosphatase 2C; Region: PP2C; pfam00481 315750004463 active site 315750004464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 315750004465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315750004466 active site 315750004467 ATP binding site [chemical binding]; other site 315750004468 substrate binding site [chemical binding]; other site 315750004469 activation loop (A-loop); other site 315750004470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 315750004471 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315750004472 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315750004473 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315750004474 GTPase RsgA; Reviewed; Region: PRK00098 315750004475 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 315750004476 RNA binding site [nucleotide binding]; other site 315750004477 homodimer interface [polypeptide binding]; other site 315750004478 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 315750004479 GTPase/Zn-binding domain interface [polypeptide binding]; other site 315750004480 GTP/Mg2+ binding site [chemical binding]; other site 315750004481 G4 box; other site 315750004482 G5 box; other site 315750004483 G1 box; other site 315750004484 Switch I region; other site 315750004485 G2 box; other site 315750004486 G3 box; other site 315750004487 Switch II region; other site 315750004488 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 315750004489 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 315750004490 substrate binding site [chemical binding]; other site 315750004491 hexamer interface [polypeptide binding]; other site 315750004492 metal binding site [ion binding]; metal-binding site 315750004493 Thiamine pyrophosphokinase; Region: TPK; cd07995 315750004494 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 315750004495 active site 315750004496 dimerization interface [polypeptide binding]; other site 315750004497 thiamine binding site [chemical binding]; other site 315750004498 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 315750004499 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 315750004500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 315750004501 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 315750004502 DAK2 domain; Region: Dak2; pfam02734 315750004503 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 315750004504 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 315750004505 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 315750004506 putative L-serine binding site [chemical binding]; other site 315750004507 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 315750004508 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 315750004509 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 315750004510 Y-family of DNA polymerases; Region: PolY; cl12025 315750004511 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 315750004512 generic binding surface II; other site 315750004513 ssDNA binding site; other site 315750004514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750004515 ATP binding site [chemical binding]; other site 315750004516 putative Mg++ binding site [ion binding]; other site 315750004517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750004518 nucleotide binding region [chemical binding]; other site 315750004519 ATP-binding site [chemical binding]; other site 315750004520 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 315750004521 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 315750004522 active site 2 [active] 315750004523 active site 1 [active] 315750004524 putative phosphate acyltransferase; Provisional; Region: PRK05331 315750004525 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 315750004526 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315750004527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750004528 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 315750004529 NAD(P) binding site [chemical binding]; other site 315750004530 homotetramer interface [polypeptide binding]; other site 315750004531 homodimer interface [polypeptide binding]; other site 315750004532 active site 315750004533 acyl carrier protein; Provisional; Region: acpP; PRK00982 315750004534 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 315750004535 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 315750004536 dimerization interface [polypeptide binding]; other site 315750004537 active site 315750004538 metal binding site [ion binding]; metal-binding site 315750004539 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 315750004540 dsRNA binding site [nucleotide binding]; other site 315750004541 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315750004542 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 315750004543 Walker A/P-loop; other site 315750004544 ATP binding site [chemical binding]; other site 315750004545 Q-loop/lid; other site 315750004546 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 315750004547 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 315750004548 ABC transporter signature motif; other site 315750004549 Walker B; other site 315750004550 D-loop; other site 315750004551 H-loop/switch region; other site 315750004552 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 315750004553 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 315750004554 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315750004555 P loop; other site 315750004556 GTP binding site [chemical binding]; other site 315750004557 putative DNA-binding protein; Validated; Region: PRK00118 315750004558 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 315750004559 signal recognition particle protein; Provisional; Region: PRK10867 315750004560 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 315750004561 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315750004562 P loop; other site 315750004563 GTP binding site [chemical binding]; other site 315750004564 Signal peptide binding domain; Region: SRP_SPB; pfam02978 315750004565 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 315750004566 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 315750004567 KH domain; Region: KH_4; pfam13083 315750004568 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 315750004569 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 315750004570 RimM N-terminal domain; Region: RimM; pfam01782 315750004571 PRC-barrel domain; Region: PRC; pfam05239 315750004572 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 315750004573 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 315750004574 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 315750004575 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 315750004576 GTP/Mg2+ binding site [chemical binding]; other site 315750004577 G4 box; other site 315750004578 G5 box; other site 315750004579 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 315750004580 G1 box; other site 315750004581 G1 box; other site 315750004582 GTP/Mg2+ binding site [chemical binding]; other site 315750004583 Switch I region; other site 315750004584 G2 box; other site 315750004585 G2 box; other site 315750004586 G3 box; other site 315750004587 G3 box; other site 315750004588 Switch II region; other site 315750004589 Switch II region; other site 315750004590 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 315750004591 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750004592 active site 315750004593 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 315750004594 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 315750004595 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 315750004596 CoA-ligase; Region: Ligase_CoA; pfam00549 315750004597 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 315750004598 CoA binding domain; Region: CoA_binding; pfam02629 315750004599 CoA-ligase; Region: Ligase_CoA; pfam00549 315750004600 DNA protecting protein DprA; Region: dprA; TIGR00732 315750004601 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 315750004602 DNA topoisomerase I; Validated; Region: PRK05582 315750004603 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 315750004604 active site 315750004605 interdomain interaction site; other site 315750004606 putative metal-binding site [ion binding]; other site 315750004607 nucleotide binding site [chemical binding]; other site 315750004608 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315750004609 domain I; other site 315750004610 DNA binding groove [nucleotide binding] 315750004611 phosphate binding site [ion binding]; other site 315750004612 domain II; other site 315750004613 domain III; other site 315750004614 nucleotide binding site [chemical binding]; other site 315750004615 catalytic site [active] 315750004616 domain IV; other site 315750004617 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315750004618 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315750004619 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 315750004620 Glucose inhibited division protein A; Region: GIDA; pfam01134 315750004621 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 315750004622 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315750004623 active site 315750004624 Int/Topo IB signature motif; other site 315750004625 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 315750004626 active site 315750004627 HslU subunit interaction site [polypeptide binding]; other site 315750004628 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 315750004629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750004630 Walker A motif; other site 315750004631 ATP binding site [chemical binding]; other site 315750004632 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 315750004633 Walker B motif; other site 315750004634 arginine finger; other site 315750004635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315750004636 transcriptional repressor CodY; Validated; Region: PRK04158 315750004637 CodY GAF-like domain; Region: CodY; pfam06018 315750004638 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 315750004639 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 315750004640 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 315750004641 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 315750004642 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 315750004643 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315750004644 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 315750004645 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 315750004646 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 315750004647 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 315750004648 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 315750004649 FliG C-terminal domain; Region: FliG_C; pfam01706 315750004650 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 315750004651 Flagellar assembly protein FliH; Region: FliH; pfam02108 315750004652 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 315750004653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 315750004654 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 315750004655 Walker A motif/ATP binding site; other site 315750004656 Walker B motif; other site 315750004657 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 315750004658 Uncharacterized conserved protein [Function unknown]; Region: COG3334 315750004659 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 315750004660 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 315750004661 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 315750004662 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 315750004663 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315750004664 Flagellar protein (FlbD); Region: FlbD; pfam06289 315750004665 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 315750004666 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 315750004667 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 315750004668 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 315750004669 flagellar motor switch protein; Validated; Region: PRK08119 315750004670 CheC-like family; Region: CheC; pfam04509 315750004671 CheC-like family; Region: CheC; pfam04509 315750004672 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315750004673 Response regulator receiver domain; Region: Response_reg; pfam00072 315750004674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750004675 active site 315750004676 phosphorylation site [posttranslational modification] 315750004677 intermolecular recognition site; other site 315750004678 dimerization interface [polypeptide binding]; other site 315750004679 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 315750004680 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 315750004681 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 315750004682 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 315750004683 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 315750004684 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 315750004685 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 315750004686 FHIPEP family; Region: FHIPEP; pfam00771 315750004687 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 315750004688 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315750004689 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 315750004690 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 315750004691 P-loop; other site 315750004692 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 315750004693 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 315750004694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750004695 active site 315750004696 phosphorylation site [posttranslational modification] 315750004697 intermolecular recognition site; other site 315750004698 dimerization interface [polypeptide binding]; other site 315750004699 CheB methylesterase; Region: CheB_methylest; pfam01339 315750004700 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 315750004701 putative binding surface; other site 315750004702 active site 315750004703 P2 response regulator binding domain; Region: P2; pfam07194 315750004704 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 315750004705 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 315750004706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750004707 ATP binding site [chemical binding]; other site 315750004708 Mg2+ binding site [ion binding]; other site 315750004709 G-X-G motif; other site 315750004710 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 315750004711 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 315750004712 putative CheA interaction surface; other site 315750004713 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 315750004714 CheC-like family; Region: CheC; pfam04509 315750004715 CheC-like family; Region: CheC; pfam04509 315750004716 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 315750004717 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 315750004718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750004719 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750004720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750004721 DNA binding residues [nucleotide binding] 315750004722 elongation factor Ts; Provisional; Region: tsf; PRK09377 315750004723 UBA/TS-N domain; Region: UBA; pfam00627 315750004724 Elongation factor TS; Region: EF_TS; pfam00889 315750004725 Elongation factor TS; Region: EF_TS; pfam00889 315750004726 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 315750004727 putative nucleotide binding site [chemical binding]; other site 315750004728 uridine monophosphate binding site [chemical binding]; other site 315750004729 homohexameric interface [polypeptide binding]; other site 315750004730 ribosome recycling factor; Reviewed; Region: frr; PRK00083 315750004731 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 315750004732 hinge region; other site 315750004733 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 315750004734 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 315750004735 catalytic residue [active] 315750004736 putative FPP diphosphate binding site; other site 315750004737 putative FPP binding hydrophobic cleft; other site 315750004738 dimer interface [polypeptide binding]; other site 315750004739 putative IPP diphosphate binding site; other site 315750004740 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 315750004741 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 315750004742 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 315750004743 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 315750004744 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 315750004745 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 315750004746 RIP metalloprotease RseP; Region: TIGR00054 315750004747 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315750004748 active site 315750004749 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 315750004750 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315750004751 protein binding site [polypeptide binding]; other site 315750004752 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315750004753 putative substrate binding region [chemical binding]; other site 315750004754 prolyl-tRNA synthetase; Provisional; Region: PRK09194 315750004755 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 315750004756 dimer interface [polypeptide binding]; other site 315750004757 motif 1; other site 315750004758 active site 315750004759 motif 2; other site 315750004760 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 315750004761 putative deacylase active site [active] 315750004762 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 315750004763 active site 315750004764 motif 3; other site 315750004765 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 315750004766 anticodon binding site; other site 315750004767 DNA polymerase III PolC; Validated; Region: polC; PRK00448 315750004768 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 315750004769 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 315750004770 generic binding surface II; other site 315750004771 generic binding surface I; other site 315750004772 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 315750004773 active site 315750004774 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315750004775 active site 315750004776 catalytic site [active] 315750004777 substrate binding site [chemical binding]; other site 315750004778 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 315750004779 endoglucanase; Region: PLN02420 315750004780 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 315750004781 Cellulose binding domain; Region: CBM_3; smart01067 315750004782 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 315750004783 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 315750004784 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 315750004785 ribosome maturation protein RimP; Reviewed; Region: PRK00092 315750004786 Sm and related proteins; Region: Sm_like; cl00259 315750004787 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 315750004788 putative oligomer interface [polypeptide binding]; other site 315750004789 putative RNA binding site [nucleotide binding]; other site 315750004790 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 315750004791 NusA N-terminal domain; Region: NusA_N; pfam08529 315750004792 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 315750004793 RNA binding site [nucleotide binding]; other site 315750004794 homodimer interface [polypeptide binding]; other site 315750004795 NusA-like KH domain; Region: KH_5; pfam13184 315750004796 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 315750004797 G-X-X-G motif; other site 315750004798 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 315750004799 putative RNA binding cleft [nucleotide binding]; other site 315750004800 hypothetical protein; Provisional; Region: PRK07714 315750004801 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315750004802 translation initiation factor IF-2; Region: IF-2; TIGR00487 315750004803 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315750004804 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 315750004805 G1 box; other site 315750004806 putative GEF interaction site [polypeptide binding]; other site 315750004807 GTP/Mg2+ binding site [chemical binding]; other site 315750004808 Switch I region; other site 315750004809 G2 box; other site 315750004810 G3 box; other site 315750004811 Switch II region; other site 315750004812 G4 box; other site 315750004813 G5 box; other site 315750004814 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 315750004815 Translation-initiation factor 2; Region: IF-2; pfam11987 315750004816 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 315750004817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 315750004818 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 315750004819 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 315750004820 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 315750004821 RNA binding site [nucleotide binding]; other site 315750004822 active site 315750004823 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 315750004824 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 315750004825 active site 315750004826 Riboflavin kinase; Region: Flavokinase; smart00904 315750004827 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 315750004828 16S/18S rRNA binding site [nucleotide binding]; other site 315750004829 S13e-L30e interaction site [polypeptide binding]; other site 315750004830 25S rRNA binding site [nucleotide binding]; other site 315750004831 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 315750004832 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 315750004833 RNase E interface [polypeptide binding]; other site 315750004834 trimer interface [polypeptide binding]; other site 315750004835 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 315750004836 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 315750004837 RNase E interface [polypeptide binding]; other site 315750004838 trimer interface [polypeptide binding]; other site 315750004839 active site 315750004840 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 315750004841 putative nucleic acid binding region [nucleotide binding]; other site 315750004842 G-X-X-G motif; other site 315750004843 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 315750004844 RNA binding site [nucleotide binding]; other site 315750004845 domain interface; other site 315750004846 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 315750004847 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 315750004848 NodB motif; other site 315750004849 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315750004850 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315750004851 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315750004852 Phosphotransferase enzyme family; Region: APH; pfam01636 315750004853 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315750004854 active site 315750004855 ATP binding site [chemical binding]; other site 315750004856 substrate binding site [chemical binding]; other site 315750004857 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 315750004858 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 315750004859 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 315750004860 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 315750004861 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 315750004862 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 315750004863 aspartate kinase I; Reviewed; Region: PRK08210 315750004864 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 315750004865 nucleotide binding site [chemical binding]; other site 315750004866 substrate binding site [chemical binding]; other site 315750004867 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 315750004868 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 315750004869 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 315750004870 dihydrodipicolinate synthase; Region: dapA; TIGR00674 315750004871 dimer interface [polypeptide binding]; other site 315750004872 active site 315750004873 catalytic residue [active] 315750004874 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315750004875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315750004876 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315750004877 Clp protease; Region: CLP_protease; pfam00574 315750004878 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 315750004879 active site 315750004880 YlzJ-like protein; Region: YlzJ; pfam14035 315750004881 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315750004882 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 315750004883 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315750004884 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 315750004885 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750004886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750004887 DNA-binding site [nucleotide binding]; DNA binding site 315750004888 UTRA domain; Region: UTRA; pfam07702 315750004889 MMPL family; Region: MMPL; pfam03176 315750004890 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315750004891 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315750004892 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315750004893 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315750004894 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315750004895 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315750004896 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750004897 MarR family; Region: MarR_2; pfam12802 315750004898 MMPL family; Region: MMPL; pfam03176 315750004899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315750004900 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 315750004901 dimer interface [polypeptide binding]; other site 315750004902 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315750004903 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315750004904 classical (c) SDRs; Region: SDR_c; cd05233 315750004905 NAD(P) binding site [chemical binding]; other site 315750004906 active site 315750004907 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 315750004908 ACT domain; Region: ACT; pfam01842 315750004909 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 315750004910 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 315750004911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750004912 non-specific DNA binding site [nucleotide binding]; other site 315750004913 salt bridge; other site 315750004914 sequence-specific DNA binding site [nucleotide binding]; other site 315750004915 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 315750004916 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 315750004917 competence damage-inducible protein A; Provisional; Region: PRK00549 315750004918 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 315750004919 putative MPT binding site; other site 315750004920 Competence-damaged protein; Region: CinA; pfam02464 315750004921 recombinase A; Provisional; Region: recA; PRK09354 315750004922 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 315750004923 hexamer interface [polypeptide binding]; other site 315750004924 Walker A motif; other site 315750004925 ATP binding site [chemical binding]; other site 315750004926 Walker B motif; other site 315750004927 phosphodiesterase; Provisional; Region: PRK12704 315750004928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750004929 Zn2+ binding site [ion binding]; other site 315750004930 Mg2+ binding site [ion binding]; other site 315750004931 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 315750004932 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315750004933 putative active site [active] 315750004934 metal binding site [ion binding]; metal-binding site 315750004935 homodimer binding site [polypeptide binding]; other site 315750004936 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 315750004937 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315750004938 Protein export membrane protein; Region: SecD_SecF; cl14618 315750004939 Threonine dehydrogenase; Region: TDH; cd05281 315750004940 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 315750004941 structural Zn binding site [ion binding]; other site 315750004942 catalytic Zn binding site [ion binding]; other site 315750004943 tetramer interface [polypeptide binding]; other site 315750004944 NADP binding site [chemical binding]; other site 315750004945 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 315750004946 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 315750004947 substrate-cofactor binding pocket; other site 315750004948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750004949 catalytic residue [active] 315750004950 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 315750004951 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315750004952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750004953 FeS/SAM binding site; other site 315750004954 TRAM domain; Region: TRAM; pfam01938 315750004955 Predicted membrane protein [Function unknown]; Region: COG4550 315750004956 Outer spore coat protein E (CotE); Region: CotE; pfam10628 315750004957 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 315750004958 MutS domain I; Region: MutS_I; pfam01624 315750004959 MutS domain II; Region: MutS_II; pfam05188 315750004960 MutS domain III; Region: MutS_III; pfam05192 315750004961 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 315750004962 Walker A/P-loop; other site 315750004963 ATP binding site [chemical binding]; other site 315750004964 Q-loop/lid; other site 315750004965 ABC transporter signature motif; other site 315750004966 Walker B; other site 315750004967 D-loop; other site 315750004968 H-loop/switch region; other site 315750004969 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 315750004970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750004971 ATP binding site [chemical binding]; other site 315750004972 Mg2+ binding site [ion binding]; other site 315750004973 G-X-G motif; other site 315750004974 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 315750004975 ATP binding site [chemical binding]; other site 315750004976 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 315750004977 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315750004978 Protein of unknown function (DUF867); Region: DUF867; pfam05908 315750004979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750004980 TPR motif; other site 315750004981 binding surface 315750004982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750004983 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 315750004984 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 315750004985 active site 315750004986 catalytic triad [active] 315750004987 Protein of unknown function (DUF867); Region: DUF867; pfam05908 315750004988 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 315750004989 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315750004990 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315750004991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750004992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750004993 YmaF family; Region: YmaF; pfam12788 315750004994 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 315750004995 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 315750004996 bacterial Hfq-like; Region: Hfq; cd01716 315750004997 hexamer interface [polypeptide binding]; other site 315750004998 Sm1 motif; other site 315750004999 RNA binding site [nucleotide binding]; other site 315750005000 Sm2 motif; other site 315750005001 YmzC-like protein; Region: YmzC; pfam14157 315750005002 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 315750005003 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 315750005004 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 315750005005 Class I ribonucleotide reductase; Region: RNR_I; cd01679 315750005006 active site 315750005007 dimer interface [polypeptide binding]; other site 315750005008 catalytic residues [active] 315750005009 effector binding site; other site 315750005010 R2 peptide binding site; other site 315750005011 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 315750005012 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 315750005013 dimer interface [polypeptide binding]; other site 315750005014 putative radical transfer pathway; other site 315750005015 diiron center [ion binding]; other site 315750005016 tyrosyl radical; other site 315750005017 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 315750005018 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315750005019 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750005020 active site 315750005021 metal binding site [ion binding]; metal-binding site 315750005022 Sporulation related domain; Region: SPOR; pfam05036 315750005023 stage V sporulation protein K; Region: spore_V_K; TIGR02881 315750005024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005025 Walker A motif; other site 315750005026 ATP binding site [chemical binding]; other site 315750005027 Walker B motif; other site 315750005028 arginine finger; other site 315750005029 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 315750005030 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 315750005031 HflX GTPase family; Region: HflX; cd01878 315750005032 G1 box; other site 315750005033 GTP/Mg2+ binding site [chemical binding]; other site 315750005034 Switch I region; other site 315750005035 G2 box; other site 315750005036 G3 box; other site 315750005037 Switch II region; other site 315750005038 G4 box; other site 315750005039 G5 box; other site 315750005040 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 315750005041 Aluminium resistance protein; Region: Alum_res; pfam06838 315750005042 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 315750005043 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750005044 DNA binding residues [nucleotide binding] 315750005045 putative dimer interface [polypeptide binding]; other site 315750005046 glutamine synthetase, type I; Region: GlnA; TIGR00653 315750005047 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 315750005048 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 315750005049 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315750005050 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 315750005051 active site 315750005052 nucleophile elbow; other site 315750005053 positive control sigma-like factor; Validated; Region: PRK06930 315750005054 positive control sigma-like factor; Validated; Region: PRK06930 315750005055 DNA binding residues [nucleotide binding] 315750005056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 315750005057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750005058 binding surface 315750005059 TPR motif; other site 315750005060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750005061 Uncharacterized conserved protein [Function unknown]; Region: COG5444 315750005062 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 315750005063 Protein of unknown function, DUF600; Region: DUF600; cl04640 315750005064 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 315750005065 Protein of unknown function, DUF600; Region: DUF600; pfam04634 315750005066 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 315750005067 ADP-ribose binding site [chemical binding]; other site 315750005068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750005069 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750005070 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315750005071 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315750005072 active site 315750005073 Uncharacterized conserved protein [Function unknown]; Region: COG5646 315750005074 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315750005075 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315750005076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750005077 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 315750005078 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 315750005079 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 315750005080 active site 315750005081 DNA binding site [nucleotide binding] 315750005082 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 315750005083 nucleotide binding site [chemical binding]; other site 315750005084 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 315750005085 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 315750005086 putative DNA binding site [nucleotide binding]; other site 315750005087 putative homodimer interface [polypeptide binding]; other site 315750005088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 315750005089 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315750005090 active site 315750005091 metal binding site [ion binding]; metal-binding site 315750005092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750005093 Rrf2 family protein; Region: rrf2_super; TIGR00738 315750005094 Transcriptional regulator; Region: Rrf2; pfam02082 315750005095 Transcriptional regulator; Region: Rrf2; cl17282 315750005096 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 315750005097 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 315750005098 NADP binding site [chemical binding]; other site 315750005099 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 315750005100 Cysteine-rich domain; Region: CCG; pfam02754 315750005101 Cysteine-rich domain; Region: CCG; pfam02754 315750005102 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 315750005103 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 315750005104 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 315750005105 Uncharacterized conserved protein [Function unknown]; Region: COG1556 315750005106 EamA-like transporter family; Region: EamA; pfam00892 315750005107 EamA-like transporter family; Region: EamA; pfam00892 315750005108 Predicted kinase [General function prediction only]; Region: COG4639 315750005109 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315750005110 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 315750005111 active site 315750005112 metal binding site [ion binding]; metal-binding site 315750005113 RNA ligase; Region: RNA_lig_T4_1; pfam09511 315750005114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750005115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750005116 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 315750005117 Cytochrome P450; Region: p450; pfam00067 315750005118 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 315750005119 Flavodoxin; Region: Flavodoxin_1; pfam00258 315750005120 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 315750005121 FAD binding pocket [chemical binding]; other site 315750005122 FAD binding motif [chemical binding]; other site 315750005123 catalytic residues [active] 315750005124 NAD binding pocket [chemical binding]; other site 315750005125 phosphate binding motif [ion binding]; other site 315750005126 beta-alpha-beta structure motif; other site 315750005127 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 315750005128 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 315750005129 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750005130 LexA repressor; Validated; Region: PRK00215 315750005131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750005132 putative DNA binding site [nucleotide binding]; other site 315750005133 putative Zn2+ binding site [ion binding]; other site 315750005134 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 315750005135 Catalytic site [active] 315750005136 cell division suppressor protein YneA; Provisional; Region: PRK14125 315750005137 LysM domain; Region: LysM; pfam01476 315750005138 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315750005139 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315750005140 catalytic residues [active] 315750005141 catalytic nucleophile [active] 315750005142 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 315750005143 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 315750005144 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 315750005145 TPP-binding site [chemical binding]; other site 315750005146 dimer interface [polypeptide binding]; other site 315750005147 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315750005148 PYR/PP interface [polypeptide binding]; other site 315750005149 dimer interface [polypeptide binding]; other site 315750005150 TPP binding site [chemical binding]; other site 315750005151 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750005152 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 315750005153 hypothetical protein; Provisional; Region: PRK01844 315750005154 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315750005155 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 315750005156 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 315750005157 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 315750005158 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 315750005159 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 315750005160 Small acid-soluble spore protein O family; Region: SspO; pfam08175 315750005161 aconitate hydratase; Validated; Region: PRK09277 315750005162 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 315750005163 substrate binding site [chemical binding]; other site 315750005164 ligand binding site [chemical binding]; other site 315750005165 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 315750005166 substrate binding site [chemical binding]; other site 315750005167 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750005168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315750005169 catalytic residues [active] 315750005170 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 315750005171 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 315750005172 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315750005173 active site 315750005174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 315750005175 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 315750005176 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 315750005177 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 315750005178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750005179 ATP binding site [chemical binding]; other site 315750005180 Mg2+ binding site [ion binding]; other site 315750005181 G-X-G motif; other site 315750005182 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315750005183 anchoring element; other site 315750005184 dimer interface [polypeptide binding]; other site 315750005185 ATP binding site [chemical binding]; other site 315750005186 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315750005187 active site 315750005188 putative metal-binding site [ion binding]; other site 315750005189 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315750005190 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 315750005191 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 315750005192 CAP-like domain; other site 315750005193 active site 315750005194 primary dimer interface [polypeptide binding]; other site 315750005195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750005196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750005197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750005198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750005199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005200 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750005201 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 315750005202 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 315750005203 active site 315750005204 FMN binding site [chemical binding]; other site 315750005205 substrate binding site [chemical binding]; other site 315750005206 homotetramer interface [polypeptide binding]; other site 315750005207 catalytic residue [active] 315750005208 MarR family; Region: MarR_2; pfam12802 315750005209 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 315750005210 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750005211 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750005212 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315750005213 threonine synthase; Validated; Region: PRK08329 315750005214 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 315750005215 homodimer interface [polypeptide binding]; other site 315750005216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750005217 catalytic residue [active] 315750005218 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750005219 homotrimer interaction site [polypeptide binding]; other site 315750005220 putative active site [active] 315750005221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 315750005222 YheO-like PAS domain; Region: PAS_6; pfam08348 315750005223 HTH domain; Region: HTH_22; pfam13309 315750005224 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315750005225 MarR family; Region: MarR_2; pfam12802 315750005226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750005227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750005228 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750005229 Predicted flavoprotein [General function prediction only]; Region: COG0431 315750005230 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315750005231 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315750005232 catalytic residues [active] 315750005233 putative monooxygenase; Provisional; Region: PRK11118 315750005234 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315750005235 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315750005236 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315750005237 active site 315750005238 catalytic motif [active] 315750005239 Zn binding site [ion binding]; other site 315750005240 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 315750005241 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315750005242 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 315750005243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750005244 DNA binding residues [nucleotide binding] 315750005245 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750005246 beta-galactosidase; Region: BGL; TIGR03356 315750005247 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750005248 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750005249 active site turn [active] 315750005250 phosphorylation site [posttranslational modification] 315750005251 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750005252 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 315750005253 HPr interaction site; other site 315750005254 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750005255 active site 315750005256 phosphorylation site [posttranslational modification] 315750005257 CAT RNA binding domain; Region: CAT_RBD; smart01061 315750005258 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750005259 PRD domain; Region: PRD; pfam00874 315750005260 PRD domain; Region: PRD; pfam00874 315750005261 Tic20-like protein; Region: Tic20; pfam09685 315750005262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750005263 HAMP domain; Region: HAMP; pfam00672 315750005264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750005265 dimer interface [polypeptide binding]; other site 315750005266 phosphorylation site [posttranslational modification] 315750005267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750005268 ATP binding site [chemical binding]; other site 315750005269 Mg2+ binding site [ion binding]; other site 315750005270 G-X-G motif; other site 315750005271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750005272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750005273 active site 315750005274 phosphorylation site [posttranslational modification] 315750005275 intermolecular recognition site; other site 315750005276 dimerization interface [polypeptide binding]; other site 315750005277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750005278 DNA binding site [nucleotide binding] 315750005279 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 315750005280 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 315750005281 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 315750005282 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 315750005283 substrate binding site [chemical binding]; other site 315750005284 active site 315750005285 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 315750005286 metal binding site [ion binding]; metal-binding site 315750005287 ligand binding site [chemical binding]; other site 315750005288 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 315750005289 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 315750005290 tetrameric interface [polypeptide binding]; other site 315750005291 NAD binding site [chemical binding]; other site 315750005292 catalytic residues [active] 315750005293 alpha-galactosidase; Provisional; Region: PRK15076 315750005294 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 315750005295 NAD binding site [chemical binding]; other site 315750005296 sugar binding site [chemical binding]; other site 315750005297 divalent metal binding site [ion binding]; other site 315750005298 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750005299 dimer interface [polypeptide binding]; other site 315750005300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750005301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750005302 dimer interface [polypeptide binding]; other site 315750005303 conserved gate region; other site 315750005304 putative PBP binding loops; other site 315750005305 ABC-ATPase subunit interface; other site 315750005306 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750005307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750005308 dimer interface [polypeptide binding]; other site 315750005309 conserved gate region; other site 315750005310 putative PBP binding loops; other site 315750005311 ABC-ATPase subunit interface; other site 315750005312 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315750005313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 315750005314 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750005315 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750005316 DNA binding site [nucleotide binding] 315750005317 domain linker motif; other site 315750005318 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 315750005319 putative ligand binding site [chemical binding]; other site 315750005320 putative dimerization interface [polypeptide binding]; other site 315750005321 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 315750005322 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 315750005323 substrate binding site [chemical binding]; other site 315750005324 hexamer interface [polypeptide binding]; other site 315750005325 metal binding site [ion binding]; metal-binding site 315750005326 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 315750005327 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 315750005328 active site 315750005329 P-loop; other site 315750005330 phosphorylation site [posttranslational modification] 315750005331 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750005332 HTH domain; Region: HTH_11; pfam08279 315750005333 PRD domain; Region: PRD; pfam00874 315750005334 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750005335 active site 315750005336 P-loop; other site 315750005337 phosphorylation site [posttranslational modification] 315750005338 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750005339 active site 315750005340 phosphorylation site [posttranslational modification] 315750005341 LXG domain of WXG superfamily; Region: LXG; pfam04740 315750005342 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750005343 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 315750005344 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750005345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750005346 putative DNA binding site [nucleotide binding]; other site 315750005347 putative Zn2+ binding site [ion binding]; other site 315750005348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750005350 putative substrate translocation pore; other site 315750005351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005352 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 315750005353 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 315750005354 intersubunit interface [polypeptide binding]; other site 315750005355 active site 315750005356 zinc binding site [ion binding]; other site 315750005357 Na+ binding site [ion binding]; other site 315750005358 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750005359 active site 315750005360 phosphorylation site [posttranslational modification] 315750005361 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315750005362 active site 315750005363 P-loop; other site 315750005364 phosphorylation site [posttranslational modification] 315750005365 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 315750005366 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 315750005367 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 315750005368 putative substrate binding site [chemical binding]; other site 315750005369 putative ATP binding site [chemical binding]; other site 315750005370 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750005371 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750005372 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750005373 putative active site [active] 315750005374 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 315750005375 PLD-like domain; Region: PLDc_2; pfam13091 315750005376 putative active site [active] 315750005377 catalytic site [active] 315750005378 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 315750005379 PLD-like domain; Region: PLDc_2; pfam13091 315750005380 putative active site [active] 315750005381 catalytic site [active] 315750005382 Protein of unknown function, DUF606; Region: DUF606; pfam04657 315750005383 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315750005384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315750005385 ligand binding site [chemical binding]; other site 315750005386 flexible hinge region; other site 315750005387 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 315750005388 Protein of unknown function, DUF606; Region: DUF606; pfam04657 315750005389 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 315750005390 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750005391 NAD binding site [chemical binding]; other site 315750005392 catalytic residues [active] 315750005393 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 315750005394 Flavodoxin; Region: Flavodoxin_1; pfam00258 315750005395 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 315750005396 FAD binding pocket [chemical binding]; other site 315750005397 FAD binding motif [chemical binding]; other site 315750005398 catalytic residues [active] 315750005399 NAD binding pocket [chemical binding]; other site 315750005400 phosphate binding motif [ion binding]; other site 315750005401 beta-alpha-beta structure motif; other site 315750005402 sulfite reductase subunit beta; Provisional; Region: PRK13504 315750005403 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315750005404 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315750005405 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315750005406 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 315750005407 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 315750005408 acyl-activating enzyme (AAE) consensus motif; other site 315750005409 putative AMP binding site [chemical binding]; other site 315750005410 putative active site [active] 315750005411 putative CoA binding site [chemical binding]; other site 315750005412 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 315750005413 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 315750005414 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 315750005415 enoyl-CoA hydratase; Provisional; Region: PRK07657 315750005416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750005417 substrate binding site [chemical binding]; other site 315750005418 oxyanion hole (OAH) forming residues; other site 315750005419 trimer interface [polypeptide binding]; other site 315750005420 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 315750005421 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 315750005422 active site 315750005423 catalytic residues [active] 315750005424 metal binding site [ion binding]; metal-binding site 315750005425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315750005426 carboxyltransferase (CT) interaction site; other site 315750005427 biotinylation site [posttranslational modification]; other site 315750005428 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 315750005429 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750005430 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 315750005431 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 315750005432 AMP-binding domain protein; Validated; Region: PRK08315 315750005433 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315750005434 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 315750005435 acyl-activating enzyme (AAE) consensus motif; other site 315750005436 putative AMP binding site [chemical binding]; other site 315750005437 putative active site [active] 315750005438 putative CoA binding site [chemical binding]; other site 315750005439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750005440 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315750005441 FAD binding site [chemical binding]; other site 315750005442 homotetramer interface [polypeptide binding]; other site 315750005443 substrate binding pocket [chemical binding]; other site 315750005444 catalytic base [active] 315750005445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 315750005446 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 315750005447 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 315750005448 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 315750005449 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 315750005450 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315750005451 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 315750005452 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 315750005453 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750005454 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 315750005455 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750005456 FAD binding domain; Region: FAD_binding_4; pfam01565 315750005457 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 315750005458 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315750005459 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315750005460 Cysteine-rich domain; Region: CCG; pfam02754 315750005461 Cysteine-rich domain; Region: CCG; pfam02754 315750005462 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750005463 Spore germination protein; Region: Spore_permease; cl17796 315750005464 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315750005465 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315750005466 Helix-turn-helix domain; Region: HTH_17; cl17695 315750005467 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315750005468 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315750005469 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 315750005470 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 315750005471 active site 315750005472 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 315750005473 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 315750005474 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750005475 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 315750005476 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315750005477 trimer interface [polypeptide binding]; other site 315750005478 active site 315750005479 substrate binding site [chemical binding]; other site 315750005480 CoA binding site [chemical binding]; other site 315750005481 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315750005482 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 315750005483 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 315750005484 putative pectinesterase; Region: PLN02432; cl01911 315750005485 Pectinesterase; Region: Pectinesterase; pfam01095 315750005486 Predicted membrane protein [Function unknown]; Region: COG2323 315750005487 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 315750005488 [2Fe-2S] cluster binding site [ion binding]; other site 315750005489 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 315750005490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750005491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750005492 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 315750005493 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 315750005494 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315750005495 Transposase domain (DUF772); Region: DUF772; pfam05598 315750005496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750005497 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750005498 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 315750005499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750005500 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 315750005501 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 315750005502 active site 315750005503 dimer interface [polypeptide binding]; other site 315750005504 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 315750005505 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315750005506 active site 315750005507 FMN binding site [chemical binding]; other site 315750005508 substrate binding site [chemical binding]; other site 315750005509 3Fe-4S cluster binding site [ion binding]; other site 315750005510 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 315750005511 domain interface; other site 315750005512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750005513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750005514 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 315750005515 putative dimerization interface [polypeptide binding]; other site 315750005516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750005517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750005518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750005519 Walker A/P-loop; other site 315750005520 ATP binding site [chemical binding]; other site 315750005521 Q-loop/lid; other site 315750005522 ABC transporter signature motif; other site 315750005523 Walker B; other site 315750005524 D-loop; other site 315750005525 H-loop/switch region; other site 315750005526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750005527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750005528 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 315750005529 Walker A/P-loop; other site 315750005530 ATP binding site [chemical binding]; other site 315750005531 Q-loop/lid; other site 315750005532 ABC transporter signature motif; other site 315750005533 Walker B; other site 315750005534 D-loop; other site 315750005535 H-loop/switch region; other site 315750005536 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 315750005537 DNA binding residues [nucleotide binding] 315750005538 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750005539 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750005540 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750005541 Transposase domain (DUF772); Region: DUF772; pfam05598 315750005542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750005543 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750005544 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750005545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750005546 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 315750005547 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 315750005548 putative catalytic cysteine [active] 315750005549 gamma-glutamyl kinase; Provisional; Region: PRK13402 315750005550 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 315750005551 nucleotide binding site [chemical binding]; other site 315750005552 homotetrameric interface [polypeptide binding]; other site 315750005553 putative phosphate binding site [ion binding]; other site 315750005554 putative allosteric binding site; other site 315750005555 PUA domain; Region: PUA; pfam01472 315750005556 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 315750005557 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315750005558 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 315750005559 Cytochrome P450; Region: p450; cl12078 315750005560 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 315750005561 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 315750005562 putative [4Fe-4S] binding site [ion binding]; other site 315750005563 putative molybdopterin cofactor binding site [chemical binding]; other site 315750005564 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 315750005565 putative molybdopterin cofactor binding site; other site 315750005566 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 315750005567 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 315750005568 N- and C-terminal domain interface [polypeptide binding]; other site 315750005569 D-xylulose kinase; Region: XylB; TIGR01312 315750005570 active site 315750005571 MgATP binding site [chemical binding]; other site 315750005572 catalytic site [active] 315750005573 metal binding site [ion binding]; metal-binding site 315750005574 xylulose binding site [chemical binding]; other site 315750005575 homodimer interface [polypeptide binding]; other site 315750005576 xylose isomerase; Provisional; Region: PRK05474 315750005577 xylose isomerase; Region: xylose_isom_A; TIGR02630 315750005578 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315750005579 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 315750005580 putative DNA binding site [nucleotide binding]; other site 315750005581 putative Zn2+ binding site [ion binding]; other site 315750005582 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750005583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750005584 nucleotide binding site [chemical binding]; other site 315750005585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 315750005586 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 315750005587 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 315750005588 inhibitor binding site; inhibition site 315750005589 active site 315750005590 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 315750005591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005592 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 315750005593 dimer interface [polypeptide binding]; other site 315750005594 putative tRNA-binding site [nucleotide binding]; other site 315750005595 YndJ-like protein; Region: YndJ; pfam14158 315750005596 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 315750005597 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 315750005598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750005599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750005600 WHG domain; Region: WHG; pfam13305 315750005601 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315750005602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 315750005603 Predicted transcriptional regulator [Transcription]; Region: COG2378 315750005604 HTH domain; Region: HTH_11; pfam08279 315750005605 WYL domain; Region: WYL; pfam13280 315750005606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750005607 dimerization interface [polypeptide binding]; other site 315750005608 putative DNA binding site [nucleotide binding]; other site 315750005609 putative Zn2+ binding site [ion binding]; other site 315750005610 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 315750005611 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315750005612 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750005613 catalytic residue [active] 315750005614 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 315750005615 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 315750005616 tetramer interface [polypeptide binding]; other site 315750005617 active site 315750005618 Mg2+/Mn2+ binding site [ion binding]; other site 315750005619 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 315750005620 2-methylcitrate dehydratase; Region: prpD; TIGR02330 315750005621 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 315750005622 dimer interface [polypeptide binding]; other site 315750005623 Citrate synthase; Region: Citrate_synt; pfam00285 315750005624 active site 315750005625 coenzyme A binding site [chemical binding]; other site 315750005626 citrylCoA binding site [chemical binding]; other site 315750005627 oxalacetate/citrate binding site [chemical binding]; other site 315750005628 catalytic triad [active] 315750005629 Predicted membrane protein [Function unknown]; Region: COG2322 315750005630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750005631 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750005632 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750005633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315750005634 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 315750005635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750005636 ATP binding site [chemical binding]; other site 315750005637 putative Mg++ binding site [ion binding]; other site 315750005638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750005639 nucleotide binding region [chemical binding]; other site 315750005640 ATP-binding site [chemical binding]; other site 315750005641 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 315750005642 HRDC domain; Region: HRDC; pfam00570 315750005643 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315750005644 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 315750005645 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315750005646 NAD(P) binding site [chemical binding]; other site 315750005647 putative active site [active] 315750005648 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 315750005649 pentamer interface [polypeptide binding]; other site 315750005650 dodecaamer interface [polypeptide binding]; other site 315750005651 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 315750005652 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750005653 NAD(P) binding site [chemical binding]; other site 315750005654 catalytic residues [active] 315750005655 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 315750005656 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 315750005657 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315750005658 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315750005659 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315750005660 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 315750005661 Sodium Bile acid symporter family; Region: SBF; cl17470 315750005662 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 315750005663 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750005664 E3 interaction surface; other site 315750005665 lipoyl attachment site [posttranslational modification]; other site 315750005666 e3 binding domain; Region: E3_binding; pfam02817 315750005667 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315750005668 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 315750005669 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 315750005670 TPP-binding site [chemical binding]; other site 315750005671 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 315750005672 dimer interface [polypeptide binding]; other site 315750005673 PYR/PP interface [polypeptide binding]; other site 315750005674 TPP binding site [chemical binding]; other site 315750005675 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 315750005676 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 315750005677 metal ion-dependent adhesion site (MIDAS); other site 315750005678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005679 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315750005680 Walker A motif; other site 315750005681 ATP binding site [chemical binding]; other site 315750005682 Walker B motif; other site 315750005683 arginine finger; other site 315750005684 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 315750005685 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 315750005686 E-class dimer interface [polypeptide binding]; other site 315750005687 P-class dimer interface [polypeptide binding]; other site 315750005688 active site 315750005689 Cu2+ binding site [ion binding]; other site 315750005690 Zn2+ binding site [ion binding]; other site 315750005691 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 315750005692 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315750005693 multidrug efflux protein; Reviewed; Region: PRK01766 315750005694 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 315750005695 cation binding site [ion binding]; other site 315750005696 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 315750005697 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 315750005698 Predicted permeases [General function prediction only]; Region: RarD; COG2962 315750005699 EamA-like transporter family; Region: EamA; pfam00892 315750005700 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 315750005701 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750005702 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315750005703 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315750005704 dimer interface [polypeptide binding]; other site 315750005705 FMN binding site [chemical binding]; other site 315750005706 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 315750005707 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 315750005708 Na binding site [ion binding]; other site 315750005709 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 315750005710 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 315750005711 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 315750005712 C-terminal peptidase (prc); Region: prc; TIGR00225 315750005713 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 315750005714 protein binding site [polypeptide binding]; other site 315750005715 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 315750005716 Catalytic dyad [active] 315750005717 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315750005718 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315750005719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750005720 S-adenosylmethionine binding site [chemical binding]; other site 315750005721 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315750005722 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315750005723 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 315750005724 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 315750005725 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315750005726 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315750005727 active site 315750005728 YozD-like protein; Region: YozD; pfam14162 315750005729 hypothetical protein; Provisional; Region: PRK13672 315750005730 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 315750005731 toxin interface [polypeptide binding]; other site 315750005732 Zn binding site [ion binding]; other site 315750005733 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 315750005734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750005735 FeS/SAM binding site; other site 315750005736 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 315750005737 PAS domain S-box; Region: sensory_box; TIGR00229 315750005738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750005739 putative active site [active] 315750005740 heme pocket [chemical binding]; other site 315750005741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005742 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 315750005743 Walker A motif; other site 315750005744 ATP binding site [chemical binding]; other site 315750005745 Walker B motif; other site 315750005746 arginine finger; other site 315750005747 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315750005748 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750005749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750005750 active site 315750005751 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 315750005752 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 315750005753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750005754 active site 315750005755 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315750005756 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 315750005757 NAD(P) binding site [chemical binding]; other site 315750005758 homodimer interface [polypeptide binding]; other site 315750005759 substrate binding site [chemical binding]; other site 315750005760 active site 315750005761 methionine sulfoxide reductase B; Provisional; Region: PRK00222 315750005762 SelR domain; Region: SelR; pfam01641 315750005763 methionine sulfoxide reductase A; Provisional; Region: PRK14054 315750005764 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750005765 MarR family; Region: MarR; pfam01047 315750005766 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315750005767 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 315750005768 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 315750005769 active site 315750005770 catalytic triad [active] 315750005771 oxyanion hole [active] 315750005772 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 315750005773 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 315750005774 Cu(I) binding site [ion binding]; other site 315750005775 EDD domain protein, DegV family; Region: DegV; TIGR00762 315750005776 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315750005777 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 315750005778 threonine dehydratase; Validated; Region: PRK08639 315750005779 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 315750005780 tetramer interface [polypeptide binding]; other site 315750005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750005782 catalytic residue [active] 315750005783 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 315750005784 putative Ile/Val binding site [chemical binding]; other site 315750005785 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 315750005786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005787 Walker A motif; other site 315750005788 ATP binding site [chemical binding]; other site 315750005789 Walker B motif; other site 315750005790 arginine finger; other site 315750005791 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 315750005792 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 315750005793 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315750005794 putative acyl-acceptor binding pocket; other site 315750005795 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 315750005796 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 315750005797 folate binding site [chemical binding]; other site 315750005798 NADP+ binding site [chemical binding]; other site 315750005799 thymidylate synthase; Reviewed; Region: thyA; PRK01827 315750005800 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 315750005801 dimerization interface [polypeptide binding]; other site 315750005802 active site 315750005803 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 315750005804 tetramer interfaces [polypeptide binding]; other site 315750005805 binuclear metal-binding site [ion binding]; other site 315750005806 YpjP-like protein; Region: YpjP; pfam14005 315750005807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750005808 S-adenosylmethionine binding site [chemical binding]; other site 315750005809 Disulphide isomerase; Region: Disulph_isomer; pfam06491 315750005810 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 315750005811 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 315750005812 Virulence factor; Region: Virulence_fact; pfam13769 315750005813 HEAT repeats; Region: HEAT_2; pfam13646 315750005814 HEAT repeats; Region: HEAT_2; pfam13646 315750005815 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 315750005816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750005817 Zn2+ binding site [ion binding]; other site 315750005818 Mg2+ binding site [ion binding]; other site 315750005819 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 315750005820 catalytic residues [active] 315750005821 dimer interface [polypeptide binding]; other site 315750005822 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 315750005823 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 315750005824 Potassium binding sites [ion binding]; other site 315750005825 Cesium cation binding sites [ion binding]; other site 315750005826 homoserine O-succinyltransferase; Provisional; Region: PRK05368 315750005827 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 315750005828 proposed active site lysine [active] 315750005829 conserved cys residue [active] 315750005830 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 315750005831 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 315750005832 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750005833 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 315750005834 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315750005835 DNA-binding site [nucleotide binding]; DNA binding site 315750005836 RNA-binding motif; other site 315750005837 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 315750005838 hypothetical protein; Validated; Region: PRK07708 315750005839 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315750005840 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750005841 active site 315750005842 conserved hypothetical integral membrane protein; Region: TIGR00697 315750005843 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315750005844 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750005845 active site 315750005846 5'-3' exonuclease; Region: 53EXOc; smart00475 315750005847 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315750005848 active site 315750005849 metal binding site 1 [ion binding]; metal-binding site 315750005850 putative 5' ssDNA interaction site; other site 315750005851 metal binding site 3; metal-binding site 315750005852 metal binding site 2 [ion binding]; metal-binding site 315750005853 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315750005854 putative DNA binding site [nucleotide binding]; other site 315750005855 putative metal binding site [ion binding]; other site 315750005856 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 315750005857 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315750005858 Dynamin family; Region: Dynamin_N; pfam00350 315750005859 G1 box; other site 315750005860 GTP/Mg2+ binding site [chemical binding]; other site 315750005861 G2 box; other site 315750005862 Switch I region; other site 315750005863 G3 box; other site 315750005864 Switch II region; other site 315750005865 G4 box; other site 315750005866 G5 box; other site 315750005867 Dynamin family; Region: Dynamin_N; pfam00350 315750005868 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315750005869 G3 box; other site 315750005870 Switch II region; other site 315750005871 GTP/Mg2+ binding site [chemical binding]; other site 315750005872 G4 box; other site 315750005873 G5 box; other site 315750005874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 315750005875 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 315750005876 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 315750005877 malonyl-CoA binding site [chemical binding]; other site 315750005878 dimer interface [polypeptide binding]; other site 315750005879 active site 315750005880 product binding site; other site 315750005881 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750005882 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315750005883 NodB motif; other site 315750005884 active site 315750005885 catalytic site [active] 315750005886 Zn binding site [ion binding]; other site 315750005887 xanthine permease; Region: pbuX; TIGR03173 315750005888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750005889 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 315750005890 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 315750005891 active site 315750005892 Zn binding site [ion binding]; other site 315750005893 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 315750005894 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 315750005895 putative transposase OrfB; Reviewed; Region: PHA02517 315750005896 HTH-like domain; Region: HTH_21; pfam13276 315750005897 Integrase core domain; Region: rve; pfam00665 315750005898 Integrase core domain; Region: rve_2; pfam13333 315750005899 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 315750005900 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 315750005901 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 315750005902 cell division protein GpsB; Provisional; Region: PRK14127 315750005903 DivIVA domain; Region: DivI1A_domain; TIGR03544 315750005904 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 315750005905 hypothetical protein; Provisional; Region: PRK13660 315750005906 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 315750005907 RNase_H superfamily; Region: RNase_H_2; pfam13482 315750005908 active site 315750005909 catalytic site [active] 315750005910 substrate binding site [chemical binding]; other site 315750005911 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 315750005912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750005913 ATP binding site [chemical binding]; other site 315750005914 putative Mg++ binding site [ion binding]; other site 315750005915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750005916 nucleotide binding region [chemical binding]; other site 315750005917 ATP-binding site [chemical binding]; other site 315750005918 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 315750005919 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 315750005920 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 315750005921 putative active site [active] 315750005922 putative FMN binding site [chemical binding]; other site 315750005923 putative substrate binding site [chemical binding]; other site 315750005924 putative catalytic residue [active] 315750005925 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 315750005926 HPr interaction site; other site 315750005927 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750005928 active site 315750005929 phosphorylation site [posttranslational modification] 315750005930 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 315750005931 YppG-like protein; Region: YppG; pfam14179 315750005932 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 315750005933 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 315750005934 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 315750005935 Transglycosylase; Region: Transgly; pfam00912 315750005936 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750005937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750005938 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315750005939 Interdomain contacts; other site 315750005940 Cytokine receptor motif; other site 315750005941 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 315750005942 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315750005943 minor groove reading motif; other site 315750005944 helix-hairpin-helix signature motif; other site 315750005945 substrate binding pocket [chemical binding]; other site 315750005946 active site 315750005947 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 315750005948 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 315750005949 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 315750005950 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 315750005951 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 315750005952 putative dimer interface [polypeptide binding]; other site 315750005953 putative anticodon binding site; other site 315750005954 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 315750005955 homodimer interface [polypeptide binding]; other site 315750005956 motif 1; other site 315750005957 motif 2; other site 315750005958 active site 315750005959 motif 3; other site 315750005960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 315750005961 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315750005962 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 315750005963 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 315750005964 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315750005965 active site 315750005966 catalytic site [active] 315750005967 substrate binding site [chemical binding]; other site 315750005968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 315750005969 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 315750005970 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 315750005971 tetramerization interface [polypeptide binding]; other site 315750005972 active site 315750005973 pantoate--beta-alanine ligase; Region: panC; TIGR00018 315750005974 Pantoate-beta-alanine ligase; Region: PanC; cd00560 315750005975 active site 315750005976 ATP-binding site [chemical binding]; other site 315750005977 pantoate-binding site; other site 315750005978 HXXH motif; other site 315750005979 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 315750005980 oligomerization interface [polypeptide binding]; other site 315750005981 active site 315750005982 metal binding site [ion binding]; metal-binding site 315750005983 Biotin operon repressor [Transcription]; Region: BirA; COG1654 315750005984 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 315750005985 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 315750005986 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 315750005987 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 315750005988 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 315750005989 active site 315750005990 NTP binding site [chemical binding]; other site 315750005991 metal binding triad [ion binding]; metal-binding site 315750005992 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 315750005993 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 315750005994 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 315750005995 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 315750005996 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 315750005997 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 315750005998 active site 315750005999 dimer interfaces [polypeptide binding]; other site 315750006000 catalytic residues [active] 315750006001 dihydrodipicolinate reductase; Provisional; Region: PRK00048 315750006002 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 315750006003 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 315750006004 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 315750006005 homodimer interface [polypeptide binding]; other site 315750006006 metal binding site [ion binding]; metal-binding site 315750006007 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750006008 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750006009 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750006010 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315750006011 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 315750006012 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 315750006013 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 315750006014 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 315750006015 interchain domain interface [polypeptide binding]; other site 315750006016 intrachain domain interface; other site 315750006017 Qi binding site; other site 315750006018 Qo binding site; other site 315750006019 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315750006020 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 315750006021 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 315750006022 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 315750006023 interchain domain interface [polypeptide binding]; other site 315750006024 intrachain domain interface; other site 315750006025 heme bH binding site [chemical binding]; other site 315750006026 Qi binding site; other site 315750006027 heme bL binding site [chemical binding]; other site 315750006028 Qo binding site; other site 315750006029 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 315750006030 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 315750006031 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 315750006032 iron-sulfur cluster [ion binding]; other site 315750006033 [2Fe-2S] cluster binding site [ion binding]; other site 315750006034 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 315750006035 hypothetical protein; Provisional; Region: PRK03636 315750006036 UPF0302 domain; Region: UPF0302; pfam08864 315750006037 IDEAL domain; Region: IDEAL; pfam08858 315750006038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750006039 TPR motif; other site 315750006040 binding surface 315750006041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006042 binding surface 315750006043 TPR motif; other site 315750006044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750006045 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 315750006046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006047 binding surface 315750006048 TPR motif; other site 315750006049 TPR repeat; Region: TPR_11; pfam13414 315750006050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006051 binding surface 315750006052 TPR motif; other site 315750006053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750006054 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 315750006055 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 315750006056 hinge; other site 315750006057 active site 315750006058 prephenate dehydrogenase; Validated; Region: PRK06545 315750006059 prephenate dehydrogenase; Validated; Region: PRK08507 315750006060 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 315750006061 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 315750006062 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750006063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006064 homodimer interface [polypeptide binding]; other site 315750006065 catalytic residue [active] 315750006066 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 315750006067 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 315750006068 substrate binding site [chemical binding]; other site 315750006069 active site 315750006070 catalytic residues [active] 315750006071 heterodimer interface [polypeptide binding]; other site 315750006072 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 315750006073 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 315750006074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006075 catalytic residue [active] 315750006076 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 315750006077 active site 315750006078 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 315750006079 active site 315750006080 ribulose/triose binding site [chemical binding]; other site 315750006081 phosphate binding site [ion binding]; other site 315750006082 substrate (anthranilate) binding pocket [chemical binding]; other site 315750006083 product (indole) binding pocket [chemical binding]; other site 315750006084 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 315750006085 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315750006086 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315750006087 anthranilate synthase component I; Provisional; Region: PRK13569 315750006088 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315750006089 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 315750006090 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 315750006091 homotrimer interaction site [polypeptide binding]; other site 315750006092 active site 315750006093 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 315750006094 active site 315750006095 dimer interface [polypeptide binding]; other site 315750006096 metal binding site [ion binding]; metal-binding site 315750006097 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 315750006098 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 315750006099 Tetramer interface [polypeptide binding]; other site 315750006100 active site 315750006101 FMN-binding site [chemical binding]; other site 315750006102 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315750006103 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 315750006104 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 315750006105 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 315750006106 active site 315750006107 multimer interface [polypeptide binding]; other site 315750006108 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 315750006109 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315750006110 substrate binding pocket [chemical binding]; other site 315750006111 chain length determination region; other site 315750006112 substrate-Mg2+ binding site; other site 315750006113 catalytic residues [active] 315750006114 aspartate-rich region 1; other site 315750006115 active site lid residues [active] 315750006116 aspartate-rich region 2; other site 315750006117 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 315750006118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006119 S-adenosylmethionine binding site [chemical binding]; other site 315750006120 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 315750006121 transcription attenuation protein MtrB; Provisional; Region: PRK13251 315750006122 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 315750006123 homodecamer interface [polypeptide binding]; other site 315750006124 GTP cyclohydrolase I; Provisional; Region: PLN03044 315750006125 active site 315750006126 putative catalytic site residues [active] 315750006127 zinc binding site [ion binding]; other site 315750006128 GTP-CH-I/GFRP interaction surface; other site 315750006129 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315750006130 IHF dimer interface [polypeptide binding]; other site 315750006131 IHF - DNA interface [nucleotide binding]; other site 315750006132 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 315750006133 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 315750006134 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 315750006135 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 315750006136 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 315750006137 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 315750006138 GTP-binding protein Der; Reviewed; Region: PRK00093 315750006139 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 315750006140 G1 box; other site 315750006141 GTP/Mg2+ binding site [chemical binding]; other site 315750006142 Switch I region; other site 315750006143 G2 box; other site 315750006144 Switch II region; other site 315750006145 G3 box; other site 315750006146 G4 box; other site 315750006147 G5 box; other site 315750006148 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 315750006149 G1 box; other site 315750006150 GTP/Mg2+ binding site [chemical binding]; other site 315750006151 Switch I region; other site 315750006152 G2 box; other site 315750006153 G3 box; other site 315750006154 Switch II region; other site 315750006155 G4 box; other site 315750006156 G5 box; other site 315750006157 YIEGIA protein; Region: YIEGIA; pfam14045 315750006158 YpzI-like protein; Region: YpzI; pfam14140 315750006159 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 315750006160 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 315750006161 homotetramer interface [polypeptide binding]; other site 315750006162 FMN binding site [chemical binding]; other site 315750006163 homodimer contacts [polypeptide binding]; other site 315750006164 putative active site [active] 315750006165 putative substrate binding site [chemical binding]; other site 315750006166 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 315750006167 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 315750006168 RNA binding site [nucleotide binding]; other site 315750006169 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 315750006170 RNA binding site [nucleotide binding]; other site 315750006171 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750006172 RNA binding site [nucleotide binding]; other site 315750006173 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 315750006174 RNA binding site [nucleotide binding]; other site 315750006175 cytidylate kinase; Provisional; Region: cmk; PRK00023 315750006176 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 315750006177 CMP-binding site; other site 315750006178 The sites determining sugar specificity; other site 315750006179 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 315750006180 Flagellar protein YcgR; Region: YcgR_2; pfam12945 315750006181 PilZ domain; Region: PilZ; pfam07238 315750006182 germination protein YpeB; Region: spore_YpeB; TIGR02889 315750006183 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315750006184 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315750006185 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315750006186 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 315750006187 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 315750006188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 315750006189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750006190 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315750006191 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315750006192 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 315750006193 NAD(P) binding site [chemical binding]; other site 315750006194 adaptor protein; Provisional; Region: PRK02899 315750006195 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315750006196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315750006197 putative active site [active] 315750006198 putative metal binding site [ion binding]; other site 315750006199 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 315750006200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750006201 CAAX protease self-immunity; Region: Abi; pfam02517 315750006202 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 315750006203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750006204 ATP binding site [chemical binding]; other site 315750006205 putative Mg++ binding site [ion binding]; other site 315750006206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750006207 nucleotide binding region [chemical binding]; other site 315750006208 ATP-binding site [chemical binding]; other site 315750006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 315750006210 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 315750006211 Predicted membrane protein [Function unknown]; Region: COG3601 315750006212 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 315750006213 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 315750006214 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 315750006215 ligand binding site [chemical binding]; other site 315750006216 NAD binding site [chemical binding]; other site 315750006217 dimerization interface [polypeptide binding]; other site 315750006218 catalytic site [active] 315750006219 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 315750006220 putative L-serine binding site [chemical binding]; other site 315750006221 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315750006222 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750006223 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750006224 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 315750006225 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 315750006226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750006227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750006228 DNA binding residues [nucleotide binding] 315750006229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315750006230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750006231 dimerization interface [polypeptide binding]; other site 315750006232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750006233 putative active site [active] 315750006234 heme pocket [chemical binding]; other site 315750006235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750006236 dimer interface [polypeptide binding]; other site 315750006237 phosphorylation site [posttranslational modification] 315750006238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750006239 ATP binding site [chemical binding]; other site 315750006240 Mg2+ binding site [ion binding]; other site 315750006241 G-X-G motif; other site 315750006242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750006243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750006244 active site 315750006245 phosphorylation site [posttranslational modification] 315750006246 intermolecular recognition site; other site 315750006247 dimerization interface [polypeptide binding]; other site 315750006248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750006249 DNA binding site [nucleotide binding] 315750006250 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315750006251 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315750006252 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 315750006253 ResB-like family; Region: ResB; pfam05140 315750006254 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750006255 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315750006256 catalytic residues [active] 315750006257 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315750006258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750006259 RNA binding surface [nucleotide binding]; other site 315750006260 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 315750006261 active site 315750006262 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 315750006263 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 315750006264 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315750006265 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315750006266 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 315750006267 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 315750006268 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 315750006269 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 315750006270 Domain of unknown function (DUF309); Region: DUF309; pfam03745 315750006271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006272 Coenzyme A binding pocket [chemical binding]; other site 315750006273 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 315750006274 homopentamer interface [polypeptide binding]; other site 315750006275 active site 315750006276 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 315750006277 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 315750006278 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 315750006279 Lumazine binding domain; Region: Lum_binding; pfam00677 315750006280 Lumazine binding domain; Region: Lum_binding; pfam00677 315750006281 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 315750006282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750006283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750006284 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750006285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006286 putative substrate translocation pore; other site 315750006287 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 315750006288 active site 315750006289 Predicted secreted protein [Function unknown]; Region: COG4086 315750006290 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 315750006291 diaminopimelate decarboxylase; Region: lysA; TIGR01048 315750006292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 315750006293 active site 315750006294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750006295 substrate binding site [chemical binding]; other site 315750006296 catalytic residues [active] 315750006297 dimer interface [polypeptide binding]; other site 315750006298 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750006299 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 315750006300 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 315750006301 stage V sporulation protein AD; Validated; Region: PRK08304 315750006302 stage V sporulation protein AD; Provisional; Region: PRK12404 315750006303 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 315750006304 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 315750006305 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 315750006306 sporulation sigma factor SigF; Validated; Region: PRK05572 315750006307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750006308 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750006309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750006310 DNA binding residues [nucleotide binding] 315750006311 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315750006312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750006313 ATP binding site [chemical binding]; other site 315750006314 Mg2+ binding site [ion binding]; other site 315750006315 G-X-G motif; other site 315750006316 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 315750006317 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315750006318 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315750006319 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 315750006320 purine nucleoside phosphorylase; Provisional; Region: PRK08202 315750006321 phosphopentomutase; Provisional; Region: PRK05362 315750006322 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 315750006323 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 315750006324 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315750006325 active site 315750006326 Int/Topo IB signature motif; other site 315750006327 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 315750006328 ferric uptake regulator; Provisional; Region: fur; PRK09462 315750006329 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315750006330 metal binding site 2 [ion binding]; metal-binding site 315750006331 putative DNA binding helix; other site 315750006332 metal binding site 1 [ion binding]; metal-binding site 315750006333 dimer interface [polypeptide binding]; other site 315750006334 structural Zn2+ binding site [ion binding]; other site 315750006335 stage II sporulation protein M; Region: spo_II_M; TIGR02831 315750006336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006337 Coenzyme A binding pocket [chemical binding]; other site 315750006338 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 315750006339 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 315750006340 PHP-associated; Region: PHP_C; pfam13263 315750006341 Y-family of DNA polymerases; Region: PolY; cl12025 315750006342 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 315750006343 dimer interface [polypeptide binding]; other site 315750006344 ADP-ribose binding site [chemical binding]; other site 315750006345 active site 315750006346 nudix motif; other site 315750006347 metal binding site [ion binding]; metal-binding site 315750006348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750006349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750006350 active site 315750006351 catalytic tetrad [active] 315750006352 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 315750006353 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315750006354 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750006355 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315750006356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006357 TPR motif; other site 315750006358 binding surface 315750006359 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750006360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006361 TPR motif; other site 315750006362 binding surface 315750006363 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 315750006364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 315750006365 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315750006366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750006368 Coenzyme A binding pocket [chemical binding]; other site 315750006369 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315750006370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315750006371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006372 Coenzyme A binding pocket [chemical binding]; other site 315750006373 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 315750006374 DNA polymerase IV; Reviewed; Region: PRK03103 315750006375 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 315750006376 active site 315750006377 DNA binding site [nucleotide binding] 315750006378 YolD-like protein; Region: YolD; pfam08863 315750006379 putative transporter; Provisional; Region: PRK10054 315750006380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006381 putative substrate translocation pore; other site 315750006382 pantothenate kinase; Provisional; Region: PRK05439 315750006383 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 315750006384 ATP-binding site [chemical binding]; other site 315750006385 CoA-binding site [chemical binding]; other site 315750006386 Mg2+-binding site [ion binding]; other site 315750006387 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 315750006388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750006389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750006390 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750006391 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 315750006392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750006393 NAD(P) binding site [chemical binding]; other site 315750006394 active site 315750006395 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315750006396 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 315750006397 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315750006398 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 315750006399 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 315750006400 putative metal binding site [ion binding]; other site 315750006401 putative dimer interface [polypeptide binding]; other site 315750006402 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 315750006403 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 315750006404 active site 315750006405 FMN binding site [chemical binding]; other site 315750006406 substrate binding site [chemical binding]; other site 315750006407 homotetramer interface [polypeptide binding]; other site 315750006408 catalytic residue [active] 315750006409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750006410 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 315750006411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750006412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006413 homodimer interface [polypeptide binding]; other site 315750006414 catalytic residue [active] 315750006415 ribonuclease Z; Region: RNase_Z; TIGR02651 315750006416 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 315750006417 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 315750006418 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 315750006419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750006420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750006421 DNA-binding site [nucleotide binding]; DNA binding site 315750006422 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 315750006423 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 315750006424 beta-galactosidase; Region: BGL; TIGR03356 315750006425 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315750006426 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 315750006427 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315750006428 active site 315750006429 methionine cluster; other site 315750006430 phosphorylation site [posttranslational modification] 315750006431 metal binding site [ion binding]; metal-binding site 315750006432 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315750006433 active site 315750006434 P-loop; other site 315750006435 phosphorylation site [posttranslational modification] 315750006436 glucose-1-dehydrogenase; Provisional; Region: PRK08936 315750006437 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 315750006438 NAD binding site [chemical binding]; other site 315750006439 homodimer interface [polypeptide binding]; other site 315750006440 active site 315750006441 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 315750006442 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315750006443 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 315750006444 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 315750006445 DNA polymerase IV; Validated; Region: PRK01810 315750006446 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 315750006447 active site 315750006448 DNA binding site [nucleotide binding] 315750006449 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315750006450 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 315750006451 putative active site [active] 315750006452 catalytic triad [active] 315750006453 putative dimer interface [polypeptide binding]; other site 315750006454 OxaA-like protein precursor; Validated; Region: PRK01622 315750006455 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 315750006456 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 315750006457 peptidase T-like protein; Region: PepT-like; TIGR01883 315750006458 metal binding site [ion binding]; metal-binding site 315750006459 putative dimer interface [polypeptide binding]; other site 315750006460 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 315750006461 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 315750006462 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 315750006463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750006464 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 315750006465 dimer interface [polypeptide binding]; other site 315750006466 substrate binding site [chemical binding]; other site 315750006467 metal binding site [ion binding]; metal-binding site 315750006468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 315750006469 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 315750006470 Predicted membrane protein [Function unknown]; Region: COG4129 315750006471 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 315750006472 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 315750006473 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750006474 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750006475 Walker A/P-loop; other site 315750006476 ATP binding site [chemical binding]; other site 315750006477 Q-loop/lid; other site 315750006478 ABC transporter signature motif; other site 315750006479 Walker B; other site 315750006480 D-loop; other site 315750006481 H-loop/switch region; other site 315750006482 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750006483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006484 dimer interface [polypeptide binding]; other site 315750006485 conserved gate region; other site 315750006486 putative PBP binding loops; other site 315750006487 ABC-ATPase subunit interface; other site 315750006488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750006489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750006490 substrate binding pocket [chemical binding]; other site 315750006491 membrane-bound complex binding site; other site 315750006492 hinge residues; other site 315750006493 Disulphide isomerase; Region: Disulph_isomer; pfam06491 315750006494 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 315750006495 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 315750006496 YesK-like protein; Region: YesK; pfam14150 315750006497 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750006498 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750006499 E3 interaction surface; other site 315750006500 lipoyl attachment site [posttranslational modification]; other site 315750006501 e3 binding domain; Region: E3_binding; pfam02817 315750006502 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315750006503 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750006504 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750006505 alpha subunit interface [polypeptide binding]; other site 315750006506 TPP binding site [chemical binding]; other site 315750006507 heterodimer interface [polypeptide binding]; other site 315750006508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750006509 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 315750006510 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750006511 tetramer interface [polypeptide binding]; other site 315750006512 TPP-binding site [chemical binding]; other site 315750006513 heterodimer interface [polypeptide binding]; other site 315750006514 phosphorylation loop region [posttranslational modification] 315750006515 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 315750006516 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 315750006517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750006518 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750006519 butyrate kinase; Provisional; Region: PRK03011 315750006520 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315750006521 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315750006522 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 315750006523 NAD binding site [chemical binding]; other site 315750006524 Phe binding site; other site 315750006525 phosphate butyryltransferase; Validated; Region: PRK07742 315750006526 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315750006527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750006528 putative active site [active] 315750006529 heme pocket [chemical binding]; other site 315750006530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750006531 putative active site [active] 315750006532 heme pocket [chemical binding]; other site 315750006533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750006534 Walker A motif; other site 315750006535 ATP binding site [chemical binding]; other site 315750006536 Walker B motif; other site 315750006537 arginine finger; other site 315750006538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315750006539 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 315750006540 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315750006541 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 315750006542 active site 315750006543 catalytic site [active] 315750006544 metal binding site [ion binding]; metal-binding site 315750006545 dimer interface [polypeptide binding]; other site 315750006546 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 315750006547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750006548 active site 315750006549 phosphorylation site [posttranslational modification] 315750006550 intermolecular recognition site; other site 315750006551 dimerization interface [polypeptide binding]; other site 315750006552 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 315750006553 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 315750006554 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315750006555 protein binding site [polypeptide binding]; other site 315750006556 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 315750006557 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 315750006558 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 315750006559 Walker A/P-loop; other site 315750006560 ATP binding site [chemical binding]; other site 315750006561 Q-loop/lid; other site 315750006562 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 315750006563 ABC transporter signature motif; other site 315750006564 Walker B; other site 315750006565 D-loop; other site 315750006566 H-loop/switch region; other site 315750006567 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 315750006568 arginine repressor; Provisional; Region: PRK04280 315750006569 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 315750006570 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 315750006571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750006572 RNA binding surface [nucleotide binding]; other site 315750006573 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 315750006574 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 315750006575 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 315750006576 TPP-binding site; other site 315750006577 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315750006578 PYR/PP interface [polypeptide binding]; other site 315750006579 dimer interface [polypeptide binding]; other site 315750006580 TPP binding site [chemical binding]; other site 315750006581 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750006582 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 315750006583 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315750006584 substrate binding pocket [chemical binding]; other site 315750006585 chain length determination region; other site 315750006586 substrate-Mg2+ binding site; other site 315750006587 catalytic residues [active] 315750006588 aspartate-rich region 1; other site 315750006589 active site lid residues [active] 315750006590 aspartate-rich region 2; other site 315750006591 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 315750006592 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 315750006593 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 315750006594 generic binding surface II; other site 315750006595 generic binding surface I; other site 315750006596 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 315750006597 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 315750006598 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 315750006599 homodimer interface [polypeptide binding]; other site 315750006600 NADP binding site [chemical binding]; other site 315750006601 substrate binding site [chemical binding]; other site 315750006602 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 315750006603 putative RNA binding site [nucleotide binding]; other site 315750006604 Asp23 family; Region: Asp23; pfam03780 315750006605 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 315750006606 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750006607 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315750006608 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 315750006609 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 315750006610 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315750006611 carboxyltransferase (CT) interaction site; other site 315750006612 biotinylation site [posttranslational modification]; other site 315750006613 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 315750006614 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 315750006615 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 315750006616 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 315750006617 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 315750006618 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 315750006619 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 315750006620 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 315750006621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750006622 Walker A motif; other site 315750006623 ATP binding site [chemical binding]; other site 315750006624 Walker B motif; other site 315750006625 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 315750006626 elongation factor P; Validated; Region: PRK00529 315750006627 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 315750006628 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 315750006629 RNA binding site [nucleotide binding]; other site 315750006630 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 315750006631 RNA binding site [nucleotide binding]; other site 315750006632 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315750006633 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315750006634 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315750006635 active site 315750006636 Dehydroquinase class II; Region: DHquinase_II; pfam01220 315750006637 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 315750006638 trimer interface [polypeptide binding]; other site 315750006639 active site 315750006640 dimer interface [polypeptide binding]; other site 315750006641 Conserved membrane protein YqhR; Region: YqhR; pfam11085 315750006642 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 315750006643 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315750006644 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 315750006645 manganese transport transcriptional regulator; Provisional; Region: PRK03902 315750006646 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 315750006647 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 315750006648 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315750006649 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750006650 active site residue [active] 315750006651 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315750006652 tetramer interface [polypeptide binding]; other site 315750006653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006654 catalytic residue [active] 315750006655 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 315750006656 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315750006657 tetramer interface [polypeptide binding]; other site 315750006658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006659 catalytic residue [active] 315750006660 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 315750006661 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 315750006662 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750006663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750006664 ATP binding site [chemical binding]; other site 315750006665 putative Mg++ binding site [ion binding]; other site 315750006666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750006667 nucleotide binding region [chemical binding]; other site 315750006668 ATP-binding site [chemical binding]; other site 315750006669 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 315750006670 Anti-repressor SinI; Region: SinI; pfam08671 315750006671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750006672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750006673 non-specific DNA binding site [nucleotide binding]; other site 315750006674 salt bridge; other site 315750006675 sequence-specific DNA binding site [nucleotide binding]; other site 315750006676 Anti-repressor SinI; Region: SinI; pfam08671 315750006677 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 315750006678 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 315750006679 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 315750006680 Catalytic site [active] 315750006681 YqxM protein; Region: YqxM_for_SipW; TIGR04087 315750006682 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 315750006683 YqzE-like protein; Region: YqzE; pfam14038 315750006684 ComG operon protein 7; Region: ComGG; pfam14173 315750006685 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 315750006686 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 315750006687 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 315750006688 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 315750006689 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 315750006690 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 315750006691 Type II/IV secretion system protein; Region: T2SE; pfam00437 315750006692 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 315750006693 Walker A motif; other site 315750006694 ATP binding site [chemical binding]; other site 315750006695 Walker B motif; other site 315750006696 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750006697 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 315750006698 ArsC family; Region: ArsC; pfam03960 315750006699 putative catalytic residues [active] 315750006700 thiol/disulfide switch; other site 315750006701 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 315750006702 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315750006703 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 315750006704 Domain of unknown function DUF77; Region: DUF77; pfam01910 315750006705 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750006706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006707 putative substrate translocation pore; other site 315750006708 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 315750006709 active site 315750006710 Zn binding site [ion binding]; other site 315750006711 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750006712 Sulfatase; Region: Sulfatase; pfam00884 315750006713 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 315750006714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750006715 nucleotide binding site [chemical binding]; other site 315750006716 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 315750006717 Rhomboid family; Region: Rhomboid; pfam01694 315750006718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006719 binding surface 315750006720 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750006721 TPR motif; other site 315750006722 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750006723 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 315750006724 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 315750006725 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 315750006726 YceG-like family; Region: YceG; pfam02618 315750006727 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 315750006728 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 315750006729 Walker A/P-loop; other site 315750006730 ATP binding site [chemical binding]; other site 315750006731 Q-loop/lid; other site 315750006732 ABC transporter signature motif; other site 315750006733 Walker B; other site 315750006734 D-loop; other site 315750006735 H-loop/switch region; other site 315750006736 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 315750006737 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 315750006738 Walker A/P-loop; other site 315750006739 ATP binding site [chemical binding]; other site 315750006740 Q-loop/lid; other site 315750006741 ABC transporter signature motif; other site 315750006742 Walker B; other site 315750006743 D-loop; other site 315750006744 H-loop/switch region; other site 315750006745 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 315750006746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006747 dimer interface [polypeptide binding]; other site 315750006748 conserved gate region; other site 315750006749 putative PBP binding loops; other site 315750006750 ABC-ATPase subunit interface; other site 315750006751 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 315750006752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006753 dimer interface [polypeptide binding]; other site 315750006754 conserved gate region; other site 315750006755 putative PBP binding loops; other site 315750006756 ABC-ATPase subunit interface; other site 315750006757 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315750006758 PBP superfamily domain; Region: PBP_like_2; cl17296 315750006759 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750006760 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750006761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750006762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750006764 putative substrate translocation pore; other site 315750006765 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315750006766 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315750006767 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315750006768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 315750006769 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 315750006770 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750006771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750006772 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 315750006773 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 315750006774 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315750006775 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315750006776 Uncharacterized conserved protein [Function unknown]; Region: COG5663 315750006777 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750006778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750006779 nucleotide binding site [chemical binding]; other site 315750006780 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315750006781 metal binding site 2 [ion binding]; metal-binding site 315750006782 putative DNA binding helix; other site 315750006783 metal binding site 1 [ion binding]; metal-binding site 315750006784 dimer interface [polypeptide binding]; other site 315750006785 structural Zn2+ binding site [ion binding]; other site 315750006786 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 315750006787 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750006788 ABC-ATPase subunit interface; other site 315750006789 dimer interface [polypeptide binding]; other site 315750006790 putative PBP binding regions; other site 315750006791 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 315750006792 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 315750006793 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750006794 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750006795 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315750006796 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 315750006797 endonuclease IV; Provisional; Region: PRK01060 315750006798 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 315750006799 AP (apurinic/apyrimidinic) site pocket; other site 315750006800 DNA interaction; other site 315750006801 Metal-binding active site; metal-binding site 315750006802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750006803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750006804 ATP binding site [chemical binding]; other site 315750006805 Mg++ binding site [ion binding]; other site 315750006806 motif III; other site 315750006807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750006808 nucleotide binding region [chemical binding]; other site 315750006809 ATP-binding site [chemical binding]; other site 315750006810 YqfQ-like protein; Region: YqfQ; pfam14181 315750006811 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 315750006812 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 315750006813 Uncharacterized conserved protein [Function unknown]; Region: COG0327 315750006814 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 315750006815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 315750006816 Uncharacterized conserved protein [Function unknown]; Region: COG0327 315750006817 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 315750006818 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 315750006819 Family of unknown function (DUF633); Region: DUF633; pfam04816 315750006820 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315750006821 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 315750006822 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 315750006823 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 315750006824 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 315750006825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750006826 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750006827 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750006828 DNA binding residues [nucleotide binding] 315750006829 DNA primase; Validated; Region: dnaG; PRK05667 315750006830 CHC2 zinc finger; Region: zf-CHC2; pfam01807 315750006831 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 315750006832 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 315750006833 active site 315750006834 metal binding site [ion binding]; metal-binding site 315750006835 interdomain interaction site; other site 315750006836 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 315750006837 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315750006838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 315750006839 PEP synthetase regulatory protein; Provisional; Region: PRK05339 315750006840 HTH domain; Region: HTH_11; pfam08279 315750006841 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 315750006842 FOG: CBS domain [General function prediction only]; Region: COG0517 315750006843 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 315750006844 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 315750006845 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 315750006846 dimer interface [polypeptide binding]; other site 315750006847 motif 1; other site 315750006848 active site 315750006849 motif 2; other site 315750006850 motif 3; other site 315750006851 Recombination protein O N terminal; Region: RecO_N; pfam11967 315750006852 DNA repair protein RecO; Region: reco; TIGR00613 315750006853 Recombination protein O C terminal; Region: RecO_C; pfam02565 315750006854 YqzL-like protein; Region: YqzL; pfam14006 315750006855 GTPase Era; Reviewed; Region: era; PRK00089 315750006856 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 315750006857 G1 box; other site 315750006858 GTP/Mg2+ binding site [chemical binding]; other site 315750006859 Switch I region; other site 315750006860 G2 box; other site 315750006861 Switch II region; other site 315750006862 G3 box; other site 315750006863 G4 box; other site 315750006864 G5 box; other site 315750006865 KH domain; Region: KH_2; pfam07650 315750006866 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315750006867 active site 315750006868 catalytic motif [active] 315750006869 Zn binding site [ion binding]; other site 315750006870 metal-binding heat shock protein; Provisional; Region: PRK00016 315750006871 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 315750006872 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 315750006873 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750006874 Zn2+ binding site [ion binding]; other site 315750006875 Mg2+ binding site [ion binding]; other site 315750006876 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 315750006877 PhoH-like protein; Region: PhoH; pfam02562 315750006878 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 315750006879 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 315750006880 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 315750006881 RES domain; Region: RES; smart00953 315750006882 hypothetical protein; Provisional; Region: PRK13665 315750006883 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 315750006884 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 315750006885 dimer interface [polypeptide binding]; other site 315750006886 active site residues [active] 315750006887 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 315750006888 Yqey-like protein; Region: YqeY; pfam09424 315750006889 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 315750006890 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 315750006891 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315750006892 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315750006893 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 315750006894 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315750006895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750006896 FeS/SAM binding site; other site 315750006897 TRAM domain; Region: TRAM; cl01282 315750006898 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 315750006899 RNA methyltransferase, RsmE family; Region: TIGR00046 315750006900 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 315750006901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006902 S-adenosylmethionine binding site [chemical binding]; other site 315750006903 chaperone protein DnaJ; Provisional; Region: PRK14280 315750006904 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 315750006905 HSP70 interaction site [polypeptide binding]; other site 315750006906 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 315750006907 substrate binding site [polypeptide binding]; other site 315750006908 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 315750006909 Zn binding sites [ion binding]; other site 315750006910 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 315750006911 dimer interface [polypeptide binding]; other site 315750006912 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 315750006913 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 315750006914 nucleotide binding site [chemical binding]; other site 315750006915 NEF interaction site [polypeptide binding]; other site 315750006916 SBD interface [polypeptide binding]; other site 315750006917 GrpE; Region: GrpE; pfam01025 315750006918 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 315750006919 dimer interface [polypeptide binding]; other site 315750006920 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 315750006921 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 315750006922 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 315750006923 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 315750006924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750006925 FeS/SAM binding site; other site 315750006926 HemN C-terminal domain; Region: HemN_C; pfam06969 315750006927 GTP-binding protein LepA; Provisional; Region: PRK05433 315750006928 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 315750006929 G1 box; other site 315750006930 putative GEF interaction site [polypeptide binding]; other site 315750006931 GTP/Mg2+ binding site [chemical binding]; other site 315750006932 Switch I region; other site 315750006933 G2 box; other site 315750006934 G3 box; other site 315750006935 Switch II region; other site 315750006936 G4 box; other site 315750006937 G5 box; other site 315750006938 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 315750006939 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 315750006940 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 315750006941 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 315750006942 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 315750006943 stage II sporulation protein P; Region: spore_II_P; TIGR02867 315750006944 germination protease; Provisional; Region: PRK02858 315750006945 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 315750006946 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 315750006947 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 315750006948 YqzM-like protein; Region: YqzM; pfam14141 315750006949 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 315750006950 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 315750006951 Competence protein; Region: Competence; pfam03772 315750006952 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315750006953 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 315750006954 catalytic motif [active] 315750006955 Zn binding site [ion binding]; other site 315750006956 SLBB domain; Region: SLBB; pfam10531 315750006957 comEA protein; Region: comE; TIGR01259 315750006958 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 315750006959 late competence protein ComER; Validated; Region: PRK07680 315750006960 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 315750006961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315750006962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006963 S-adenosylmethionine binding site [chemical binding]; other site 315750006964 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 315750006965 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750006966 Zn2+ binding site [ion binding]; other site 315750006967 Mg2+ binding site [ion binding]; other site 315750006968 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 315750006969 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 315750006970 active site 315750006971 (T/H)XGH motif; other site 315750006972 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 315750006973 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 315750006974 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 315750006975 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315750006976 shikimate binding site; other site 315750006977 NAD(P) binding site [chemical binding]; other site 315750006978 GTPase YqeH; Provisional; Region: PRK13796 315750006979 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 315750006980 GTP/Mg2+ binding site [chemical binding]; other site 315750006981 G4 box; other site 315750006982 G5 box; other site 315750006983 G1 box; other site 315750006984 Switch I region; other site 315750006985 G2 box; other site 315750006986 G3 box; other site 315750006987 Switch II region; other site 315750006988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750006989 motif II; other site 315750006990 Sporulation inhibitor A; Region: Sda; pfam08970 315750006991 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315750006992 active site 315750006993 catalytic triad [active] 315750006994 oxyanion hole [active] 315750006995 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750006996 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 315750006997 NodB motif; other site 315750006998 putative active site [active] 315750006999 putative catalytic site [active] 315750007000 putative Zn binding site [ion binding]; other site 315750007001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750007002 binding surface 315750007003 TPR motif; other site 315750007004 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750007005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750007006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750007007 binding surface 315750007008 TPR motif; other site 315750007009 sporulation sigma factor SigK; Reviewed; Region: PRK05803 315750007010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750007011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750007012 DNA binding residues [nucleotide binding] 315750007013 Transposase domain (DUF772); Region: DUF772; pfam05598 315750007014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750007015 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750007016 Immunity protein Imm6; Region: Imm6; pfam14434 315750007017 Domain of unknown function (DUF955); Region: DUF955; cl01076 315750007018 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 315750007019 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750007020 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750007021 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750007022 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750007023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750007024 Coenzyme A binding pocket [chemical binding]; other site 315750007025 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 315750007026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750007027 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 315750007028 putative substrate translocation pore; other site 315750007029 L-arabinose isomerase; Provisional; Region: PRK02929 315750007030 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 315750007031 hexamer (dimer of trimers) interface [polypeptide binding]; other site 315750007032 trimer interface [polypeptide binding]; other site 315750007033 substrate binding site [chemical binding]; other site 315750007034 Mn binding site [ion binding]; other site 315750007035 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 315750007036 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 315750007037 intersubunit interface [polypeptide binding]; other site 315750007038 active site 315750007039 Zn2+ binding site [ion binding]; other site 315750007040 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 315750007041 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 315750007042 putative N- and C-terminal domain interface [polypeptide binding]; other site 315750007043 putative active site [active] 315750007044 MgATP binding site [chemical binding]; other site 315750007045 catalytic site [active] 315750007046 metal binding site [ion binding]; metal-binding site 315750007047 putative carbohydrate binding site [chemical binding]; other site 315750007048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750007049 DNA-binding site [nucleotide binding]; DNA binding site 315750007050 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750007051 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 315750007052 putative dimerization interface [polypeptide binding]; other site 315750007053 putative ligand binding site [chemical binding]; other site 315750007054 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 315750007055 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 315750007056 catalytic residues [active] 315750007057 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750007058 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 315750007059 tetramer interface [polypeptide binding]; other site 315750007060 active site 315750007061 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 315750007062 active site 315750007063 dimer interface [polypeptide binding]; other site 315750007064 magnesium binding site [ion binding]; other site 315750007065 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750007066 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315750007067 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 315750007068 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315750007069 YxiJ-like protein; Region: YxiJ; pfam14176 315750007070 RHS Repeat; Region: RHS_repeat; pfam05593 315750007071 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 315750007072 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 315750007073 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 315750007074 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 315750007075 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 315750007076 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 315750007077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750007078 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 315750007079 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 315750007080 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750007081 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750007082 Walker A/P-loop; other site 315750007083 ATP binding site [chemical binding]; other site 315750007084 Q-loop/lid; other site 315750007085 ABC transporter signature motif; other site 315750007086 Walker B; other site 315750007087 D-loop; other site 315750007088 H-loop/switch region; other site 315750007089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750007090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750007091 substrate binding pocket [chemical binding]; other site 315750007092 membrane-bound complex binding site; other site 315750007093 hinge residues; other site 315750007094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750007095 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750007096 dimer interface [polypeptide binding]; other site 315750007097 conserved gate region; other site 315750007098 putative PBP binding loops; other site 315750007099 ABC-ATPase subunit interface; other site 315750007100 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750007101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750007102 dimer interface [polypeptide binding]; other site 315750007103 conserved gate region; other site 315750007104 putative PBP binding loops; other site 315750007105 ABC-ATPase subunit interface; other site 315750007106 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 315750007107 dimanganese center [ion binding]; other site 315750007108 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 315750007109 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315750007110 putative NAD(P) binding site [chemical binding]; other site 315750007111 catalytic Zn binding site [ion binding]; other site 315750007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750007113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750007114 putative substrate translocation pore; other site 315750007115 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315750007116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007117 NAD(P) binding site [chemical binding]; other site 315750007118 active site 315750007119 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315750007120 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 315750007121 active site 315750007122 metal binding site [ion binding]; metal-binding site 315750007123 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315750007124 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315750007125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750007126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750007127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750007128 dimerization interface [polypeptide binding]; other site 315750007129 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750007130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750007131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750007132 Walker A/P-loop; other site 315750007133 ATP binding site [chemical binding]; other site 315750007134 Q-loop/lid; other site 315750007135 ABC transporter signature motif; other site 315750007136 Walker B; other site 315750007137 D-loop; other site 315750007138 H-loop/switch region; other site 315750007139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750007140 Coenzyme A binding pocket [chemical binding]; other site 315750007141 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 315750007142 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 315750007143 NAD binding site [chemical binding]; other site 315750007144 catalytic Zn binding site [ion binding]; other site 315750007145 structural Zn binding site [ion binding]; other site 315750007146 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315750007147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750007148 S-adenosylmethionine binding site [chemical binding]; other site 315750007149 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315750007150 YrhC-like protein; Region: YrhC; pfam14143 315750007151 cystathionine beta-lyase; Provisional; Region: PRK07671 315750007152 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750007153 homodimer interface [polypeptide binding]; other site 315750007154 substrate-cofactor binding pocket; other site 315750007155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007156 catalytic residue [active] 315750007157 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315750007158 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315750007159 dimer interface [polypeptide binding]; other site 315750007160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007161 catalytic residue [active] 315750007162 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 315750007163 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 315750007164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315750007165 Methyltransferase domain; Region: Methyltransf_18; pfam12847 315750007166 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 315750007167 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315750007168 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750007169 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750007170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315750007171 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 315750007172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 315750007173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 315750007174 Transposase domain (DUF772); Region: DUF772; pfam05598 315750007175 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750007176 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750007177 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 315750007178 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 315750007179 ATP-binding site [chemical binding]; other site 315750007180 Sugar specificity; other site 315750007181 Pyrimidine base specificity; other site 315750007182 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 315750007183 Peptidase family U32; Region: Peptidase_U32; pfam01136 315750007184 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 315750007185 Peptidase family U32; Region: Peptidase_U32; pfam01136 315750007186 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315750007187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750007188 S-adenosylmethionine binding site [chemical binding]; other site 315750007189 YceG-like family; Region: YceG; pfam02618 315750007190 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 315750007191 dimerization interface [polypeptide binding]; other site 315750007192 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 315750007193 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315750007194 dimer interface [polypeptide binding]; other site 315750007195 active site 315750007196 acyl-CoA synthetase; Validated; Region: PRK07638 315750007197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315750007198 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 315750007199 acyl-activating enzyme (AAE) consensus motif; other site 315750007200 acyl-activating enzyme (AAE) consensus motif; other site 315750007201 AMP binding site [chemical binding]; other site 315750007202 active site 315750007203 CoA binding site [chemical binding]; other site 315750007204 BioY family; Region: BioY; pfam02632 315750007205 hypothetical protein; Provisional; Region: PRK13678 315750007206 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 315750007207 hypothetical protein; Provisional; Region: PRK05473 315750007208 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 315750007209 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 315750007210 motif 1; other site 315750007211 active site 315750007212 motif 2; other site 315750007213 motif 3; other site 315750007214 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315750007215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 315750007216 DHHA1 domain; Region: DHHA1; pfam02272 315750007217 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315750007218 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750007219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750007220 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750007221 Walker A/P-loop; other site 315750007222 ATP binding site [chemical binding]; other site 315750007223 Q-loop/lid; other site 315750007224 ABC transporter signature motif; other site 315750007225 Walker B; other site 315750007226 D-loop; other site 315750007227 H-loop/switch region; other site 315750007228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750007229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750007230 substrate binding pocket [chemical binding]; other site 315750007231 membrane-bound complex binding site; other site 315750007232 hinge residues; other site 315750007233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750007235 dimer interface [polypeptide binding]; other site 315750007236 conserved gate region; other site 315750007237 putative PBP binding loops; other site 315750007238 ABC-ATPase subunit interface; other site 315750007239 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750007240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750007241 dimer interface [polypeptide binding]; other site 315750007242 conserved gate region; other site 315750007243 putative PBP binding loops; other site 315750007244 ABC-ATPase subunit interface; other site 315750007245 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 315750007246 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 315750007247 AAA domain; Region: AAA_30; pfam13604 315750007248 Family description; Region: UvrD_C_2; pfam13538 315750007249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750007250 binding surface 315750007251 TPR motif; other site 315750007252 TPR repeat; Region: TPR_11; pfam13414 315750007253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750007254 binding surface 315750007255 TPR motif; other site 315750007256 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 315750007257 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 315750007258 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 315750007259 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 315750007260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315750007261 catalytic residue [active] 315750007262 Predicted transcriptional regulator [Transcription]; Region: COG1959 315750007263 Transcriptional regulator; Region: Rrf2; pfam02082 315750007264 recombination factor protein RarA; Reviewed; Region: PRK13342 315750007265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007266 Walker A motif; other site 315750007267 ATP binding site [chemical binding]; other site 315750007268 Walker B motif; other site 315750007269 arginine finger; other site 315750007270 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 315750007271 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 315750007272 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 315750007273 putative ATP binding site [chemical binding]; other site 315750007274 putative substrate interface [chemical binding]; other site 315750007275 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 315750007276 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 315750007277 dimer interface [polypeptide binding]; other site 315750007278 anticodon binding site; other site 315750007279 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 315750007280 homodimer interface [polypeptide binding]; other site 315750007281 motif 1; other site 315750007282 active site 315750007283 motif 2; other site 315750007284 GAD domain; Region: GAD; pfam02938 315750007285 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 315750007286 motif 3; other site 315750007287 histidyl-tRNA synthetase; Region: hisS; TIGR00442 315750007288 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 315750007289 dimer interface [polypeptide binding]; other site 315750007290 motif 1; other site 315750007291 active site 315750007292 motif 2; other site 315750007293 motif 3; other site 315750007294 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 315750007295 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 315750007296 Bacterial SH3 domain; Region: SH3_3; pfam08239 315750007297 Bacterial SH3 domain; Region: SH3_3; pfam08239 315750007298 Bacterial SH3 domain; Region: SH3_3; pfam08239 315750007299 Bacterial SH3 domain; Region: SH3_3; pfam08239 315750007300 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315750007301 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750007302 active site 315750007303 metal binding site [ion binding]; metal-binding site 315750007304 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 315750007305 putative active site [active] 315750007306 dimerization interface [polypeptide binding]; other site 315750007307 putative tRNAtyr binding site [nucleotide binding]; other site 315750007308 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 315750007309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750007310 Zn2+ binding site [ion binding]; other site 315750007311 Mg2+ binding site [ion binding]; other site 315750007312 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315750007313 synthetase active site [active] 315750007314 NTP binding site [chemical binding]; other site 315750007315 metal binding site [ion binding]; metal-binding site 315750007316 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 315750007317 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 315750007318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750007319 active site 315750007320 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 315750007321 DHH family; Region: DHH; pfam01368 315750007322 DHHA1 domain; Region: DHHA1; pfam02272 315750007323 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 315750007324 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 315750007325 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 315750007326 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 315750007327 Protein export membrane protein; Region: SecD_SecF; pfam02355 315750007328 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 315750007329 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315750007330 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315750007331 Predicted membrane protein [Function unknown]; Region: COG2323 315750007332 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 315750007333 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 315750007334 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 315750007335 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 315750007336 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 315750007337 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 315750007338 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 315750007339 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 315750007340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007341 Walker A motif; other site 315750007342 ATP binding site [chemical binding]; other site 315750007343 Walker B motif; other site 315750007344 arginine finger; other site 315750007345 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 315750007346 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 315750007347 RuvA N terminal domain; Region: RuvA_N; pfam01330 315750007348 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 315750007349 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 315750007350 BofC C-terminal domain; Region: BofC_C; pfam08955 315750007351 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315750007352 active site 315750007353 substrate binding site [chemical binding]; other site 315750007354 ATP binding site [chemical binding]; other site 315750007355 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 315750007356 ThiC-associated domain; Region: ThiC-associated; pfam13667 315750007357 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 315750007358 LysE type translocator; Region: LysE; pfam01810 315750007359 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750007360 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750007361 quinolinate synthetase; Provisional; Region: PRK09375 315750007362 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 315750007363 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 315750007364 dimerization interface [polypeptide binding]; other site 315750007365 active site 315750007366 L-aspartate oxidase; Provisional; Region: PRK08071 315750007367 L-aspartate oxidase; Provisional; Region: PRK06175 315750007368 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315750007369 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 315750007370 HTH domain; Region: HTH_11; pfam08279 315750007371 3H domain; Region: 3H; pfam02829 315750007372 prephenate dehydratase; Provisional; Region: PRK11898 315750007373 Prephenate dehydratase; Region: PDT; pfam00800 315750007374 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 315750007375 putative L-Phe binding site [chemical binding]; other site 315750007376 hypothetical protein; Provisional; Region: PRK04435 315750007377 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 315750007378 GTPase CgtA; Reviewed; Region: obgE; PRK12297 315750007379 GTP1/OBG; Region: GTP1_OBG; pfam01018 315750007380 Obg GTPase; Region: Obg; cd01898 315750007381 G1 box; other site 315750007382 GTP/Mg2+ binding site [chemical binding]; other site 315750007383 Switch I region; other site 315750007384 G2 box; other site 315750007385 G3 box; other site 315750007386 Switch II region; other site 315750007387 G4 box; other site 315750007388 G5 box; other site 315750007389 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 315750007390 sensory histidine kinase DcuS; Provisional; Region: PRK11086 315750007391 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 315750007392 hypothetical protein; Provisional; Region: PRK14553 315750007393 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 315750007394 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 315750007395 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 315750007396 Peptidase family M50; Region: Peptidase_M50; pfam02163 315750007397 active site 315750007398 putative substrate binding region [chemical binding]; other site 315750007399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315750007400 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750007401 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 315750007402 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 315750007403 Switch I; other site 315750007404 Switch II; other site 315750007405 septum formation inhibitor; Reviewed; Region: minC; PRK00513 315750007406 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 315750007407 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 315750007408 rod shape-determining protein MreC; Region: mreC; TIGR00219 315750007409 rod shape-determining protein MreC; Region: MreC; pfam04085 315750007410 rod shape-determining protein MreB; Provisional; Region: PRK13927 315750007411 MreB and similar proteins; Region: MreB_like; cd10225 315750007412 nucleotide binding site [chemical binding]; other site 315750007413 Mg binding site [ion binding]; other site 315750007414 putative protofilament interaction site [polypeptide binding]; other site 315750007415 RodZ interaction site [polypeptide binding]; other site 315750007416 hypothetical protein; Reviewed; Region: PRK00024 315750007417 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 315750007418 MPN+ (JAMM) motif; other site 315750007419 Zinc-binding site [ion binding]; other site 315750007420 Maf-like protein; Region: Maf; pfam02545 315750007421 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 315750007422 active site 315750007423 dimer interface [polypeptide binding]; other site 315750007424 Sporulation related domain; Region: SPOR; pfam05036 315750007425 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 315750007426 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 315750007427 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 315750007428 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 315750007429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750007430 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750007431 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 315750007432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315750007433 active site 315750007434 HIGH motif; other site 315750007435 nucleotide binding site [chemical binding]; other site 315750007436 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315750007437 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 315750007438 active site 315750007439 KMSKS motif; other site 315750007440 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 315750007441 tRNA binding surface [nucleotide binding]; other site 315750007442 anticodon binding site; other site 315750007443 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 315750007444 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 315750007445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750007446 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 315750007447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750007448 inhibitor-cofactor binding pocket; inhibition site 315750007449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007450 catalytic residue [active] 315750007451 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 315750007452 dimer interface [polypeptide binding]; other site 315750007453 active site 315750007454 Schiff base residues; other site 315750007455 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 315750007456 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 315750007457 active site 315750007458 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 315750007459 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 315750007460 domain interfaces; other site 315750007461 active site 315750007462 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 315750007463 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 315750007464 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 315750007465 tRNA; other site 315750007466 putative tRNA binding site [nucleotide binding]; other site 315750007467 putative NADP binding site [chemical binding]; other site 315750007468 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 315750007469 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 315750007470 G1 box; other site 315750007471 GTP/Mg2+ binding site [chemical binding]; other site 315750007472 Switch I region; other site 315750007473 G2 box; other site 315750007474 G3 box; other site 315750007475 Switch II region; other site 315750007476 G4 box; other site 315750007477 G5 box; other site 315750007478 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 315750007479 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315750007480 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315750007481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007482 Walker A motif; other site 315750007483 ATP binding site [chemical binding]; other site 315750007484 Walker B motif; other site 315750007485 arginine finger; other site 315750007486 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 315750007487 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 315750007488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007489 Walker A motif; other site 315750007490 ATP binding site [chemical binding]; other site 315750007491 Walker B motif; other site 315750007492 arginine finger; other site 315750007493 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 315750007494 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 315750007495 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 315750007496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007497 Walker A motif; other site 315750007498 ATP binding site [chemical binding]; other site 315750007499 Walker B motif; other site 315750007500 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315750007501 trigger factor; Provisional; Region: tig; PRK01490 315750007502 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 315750007503 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 315750007504 TPR repeat; Region: TPR_11; pfam13414 315750007505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750007506 binding surface 315750007507 TPR motif; other site 315750007508 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 315750007509 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 315750007510 substrate binding site [chemical binding]; other site 315750007511 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 315750007512 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 315750007513 substrate binding site [chemical binding]; other site 315750007514 ligand binding site [chemical binding]; other site 315750007515 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 315750007516 tartrate dehydrogenase; Region: TTC; TIGR02089 315750007517 2-isopropylmalate synthase; Validated; Region: PRK00915 315750007518 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 315750007519 active site 315750007520 catalytic residues [active] 315750007521 metal binding site [ion binding]; metal-binding site 315750007522 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 315750007523 ketol-acid reductoisomerase; Provisional; Region: PRK05479 315750007524 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 315750007525 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 315750007526 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 315750007527 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 315750007528 putative valine binding site [chemical binding]; other site 315750007529 dimer interface [polypeptide binding]; other site 315750007530 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 315750007531 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 315750007532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315750007533 PYR/PP interface [polypeptide binding]; other site 315750007534 dimer interface [polypeptide binding]; other site 315750007535 TPP binding site [chemical binding]; other site 315750007536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315750007537 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 315750007538 TPP-binding site [chemical binding]; other site 315750007539 dimer interface [polypeptide binding]; other site 315750007540 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315750007541 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315750007542 homodimer interface [polypeptide binding]; other site 315750007543 substrate-cofactor binding pocket; other site 315750007544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007545 catalytic residue [active] 315750007546 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315750007547 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 315750007548 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 315750007549 DltD N-terminal region; Region: DltD_N; pfam04915 315750007550 DltD central region; Region: DltD_M; pfam04918 315750007551 DltD C-terminal region; Region: DltD_C; pfam04914 315750007552 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 315750007553 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 315750007554 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 315750007555 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 315750007556 acyl-activating enzyme (AAE) consensus motif; other site 315750007557 AMP binding site [chemical binding]; other site 315750007558 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 315750007559 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 315750007560 putative dimer interface [polypeptide binding]; other site 315750007561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750007562 ligand binding site [chemical binding]; other site 315750007563 Zn binding site [ion binding]; other site 315750007564 Autophagy protein Apg9; Region: APG9; pfam04109 315750007565 LXG domain of WXG superfamily; Region: LXG; pfam04740 315750007566 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750007567 short chain dehydrogenase; Provisional; Region: PRK06701 315750007568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007569 NAD(P) binding site [chemical binding]; other site 315750007570 active site 315750007571 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 315750007572 active site 315750007573 metal binding site [ion binding]; metal-binding site 315750007574 homotetramer interface [polypeptide binding]; other site 315750007575 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 315750007576 active site 315750007577 dimerization interface [polypeptide binding]; other site 315750007578 ribonuclease PH; Reviewed; Region: rph; PRK00173 315750007579 Ribonuclease PH; Region: RNase_PH_bact; cd11362 315750007580 hexamer interface [polypeptide binding]; other site 315750007581 active site 315750007582 Sporulation and spore germination; Region: Germane; pfam10646 315750007583 Spore germination protein [General function prediction only]; Region: COG5401 315750007584 Sporulation and spore germination; Region: Germane; pfam10646 315750007585 glutamate racemase; Provisional; Region: PRK00865 315750007586 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750007587 MarR family; Region: MarR; pfam01047 315750007588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750007589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750007590 DNA binding residues [nucleotide binding] 315750007591 dimerization interface [polypeptide binding]; other site 315750007592 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 315750007593 Citrate transporter; Region: CitMHS; pfam03600 315750007594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750007595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750007596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750007597 dimerization interface [polypeptide binding]; other site 315750007598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 315750007599 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 315750007600 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 315750007601 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315750007602 active site 315750007603 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 315750007604 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 315750007605 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315750007606 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 315750007607 L-aspartate oxidase; Provisional; Region: PRK06175 315750007608 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315750007609 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 315750007610 putative Iron-sulfur protein interface [polypeptide binding]; other site 315750007611 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 315750007612 proximal heme binding site [chemical binding]; other site 315750007613 distal heme binding site [chemical binding]; other site 315750007614 putative dimer interface [polypeptide binding]; other site 315750007615 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 315750007616 aspartate kinase; Reviewed; Region: PRK06635 315750007617 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 315750007618 putative nucleotide binding site [chemical binding]; other site 315750007619 putative catalytic residues [active] 315750007620 putative Mg ion binding site [ion binding]; other site 315750007621 putative aspartate binding site [chemical binding]; other site 315750007622 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 315750007623 putative allosteric regulatory site; other site 315750007624 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 315750007625 putative allosteric regulatory residue; other site 315750007626 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 315750007627 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315750007628 GIY-YIG motif/motif A; other site 315750007629 active site 315750007630 catalytic site [active] 315750007631 putative DNA binding site [nucleotide binding]; other site 315750007632 metal binding site [ion binding]; metal-binding site 315750007633 UvrB/uvrC motif; Region: UVR; pfam02151 315750007634 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 315750007635 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750007636 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315750007637 catalytic residues [active] 315750007638 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 315750007639 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 315750007640 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 315750007641 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 315750007642 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 315750007643 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 315750007644 Ligand binding site [chemical binding]; other site 315750007645 Electron transfer flavoprotein domain; Region: ETF; pfam01012 315750007646 enoyl-CoA hydratase; Provisional; Region: PRK07658 315750007647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750007648 substrate binding site [chemical binding]; other site 315750007649 oxyanion hole (OAH) forming residues; other site 315750007650 trimer interface [polypeptide binding]; other site 315750007651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750007652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750007653 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 315750007654 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 315750007655 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 315750007656 acyl-activating enzyme (AAE) consensus motif; other site 315750007657 putative AMP binding site [chemical binding]; other site 315750007658 putative active site [active] 315750007659 putative CoA binding site [chemical binding]; other site 315750007660 Predicted membrane protein [Function unknown]; Region: COG3766 315750007661 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315750007662 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315750007663 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 315750007664 MutS domain III; Region: MutS_III; pfam05192 315750007665 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 315750007666 Walker A/P-loop; other site 315750007667 ATP binding site [chemical binding]; other site 315750007668 Q-loop/lid; other site 315750007669 ABC transporter signature motif; other site 315750007670 Walker B; other site 315750007671 D-loop; other site 315750007672 H-loop/switch region; other site 315750007673 Smr domain; Region: Smr; pfam01713 315750007674 hypothetical protein; Provisional; Region: PRK08609 315750007675 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 315750007676 active site 315750007677 primer binding site [nucleotide binding]; other site 315750007678 NTP binding site [chemical binding]; other site 315750007679 metal binding triad [ion binding]; metal-binding site 315750007680 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 315750007681 active site 315750007682 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 315750007683 Colicin V production protein; Region: Colicin_V; pfam02674 315750007684 cell division protein ZapA; Provisional; Region: PRK14126 315750007685 ribonuclease HIII; Provisional; Region: PRK00996 315750007686 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 315750007687 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 315750007688 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750007689 active site 315750007690 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 315750007691 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315750007692 putative tRNA-binding site [nucleotide binding]; other site 315750007693 B3/4 domain; Region: B3_4; pfam03483 315750007694 tRNA synthetase B5 domain; Region: B5; smart00874 315750007695 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 315750007696 dimer interface [polypeptide binding]; other site 315750007697 motif 1; other site 315750007698 motif 3; other site 315750007699 motif 2; other site 315750007700 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 315750007701 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 315750007702 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 315750007703 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 315750007704 dimer interface [polypeptide binding]; other site 315750007705 motif 1; other site 315750007706 active site 315750007707 motif 2; other site 315750007708 motif 3; other site 315750007709 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 315750007710 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 315750007711 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 315750007712 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 315750007713 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 315750007714 Carbon starvation protein CstA; Region: CstA; pfam02554 315750007715 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 315750007716 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315750007717 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315750007718 oligomer interface [polypeptide binding]; other site 315750007719 active site 315750007720 metal binding site [ion binding]; metal-binding site 315750007721 Predicted membrane protein [Function unknown]; Region: COG3326 315750007722 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 315750007723 23S rRNA binding site [nucleotide binding]; other site 315750007724 L21 binding site [polypeptide binding]; other site 315750007725 L13 binding site [polypeptide binding]; other site 315750007726 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 315750007727 antiholin-like protein LrgB; Provisional; Region: PRK04288 315750007728 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 315750007729 two-component response regulator; Provisional; Region: PRK14084 315750007730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007731 active site 315750007732 phosphorylation site [posttranslational modification] 315750007733 intermolecular recognition site; other site 315750007734 dimerization interface [polypeptide binding]; other site 315750007735 LytTr DNA-binding domain; Region: LytTR; smart00850 315750007736 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 315750007737 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315750007738 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 315750007739 Histidine kinase; Region: His_kinase; pfam06580 315750007740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007741 ATP binding site [chemical binding]; other site 315750007742 Mg2+ binding site [ion binding]; other site 315750007743 G-X-G motif; other site 315750007744 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 315750007745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750007746 motif II; other site 315750007747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750007748 PAS domain; Region: PAS_9; pfam13426 315750007749 putative active site [active] 315750007750 heme pocket [chemical binding]; other site 315750007751 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315750007752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750007753 dimer interface [polypeptide binding]; other site 315750007754 putative CheW interface [polypeptide binding]; other site 315750007755 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 315750007756 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315750007757 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315750007758 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315750007759 active site 315750007760 dimer interface [polypeptide binding]; other site 315750007761 motif 1; other site 315750007762 motif 2; other site 315750007763 motif 3; other site 315750007764 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315750007765 anticodon binding site; other site 315750007766 YtxC-like family; Region: YtxC; pfam08812 315750007767 Uncharacterized conserved protein [Function unknown]; Region: COG0398 315750007768 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315750007769 primosomal protein DnaI; Reviewed; Region: PRK08939 315750007770 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 315750007771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007772 Walker A motif; other site 315750007773 ATP binding site [chemical binding]; other site 315750007774 Walker B motif; other site 315750007775 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 315750007776 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 315750007777 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 315750007778 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 315750007779 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 315750007780 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 315750007781 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 315750007782 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 315750007783 CoA-binding site [chemical binding]; other site 315750007784 ATP-binding [chemical binding]; other site 315750007785 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 315750007786 Domain of unknown function DUF; Region: DUF204; pfam02659 315750007787 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 315750007788 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 315750007789 DNA binding site [nucleotide binding] 315750007790 catalytic residue [active] 315750007791 H2TH interface [polypeptide binding]; other site 315750007792 putative catalytic residues [active] 315750007793 turnover-facilitating residue; other site 315750007794 intercalation triad [nucleotide binding]; other site 315750007795 8OG recognition residue [nucleotide binding]; other site 315750007796 putative reading head residues; other site 315750007797 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 315750007798 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 315750007799 DNA polymerase I; Provisional; Region: PRK05755 315750007800 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315750007801 active site 315750007802 metal binding site 1 [ion binding]; metal-binding site 315750007803 putative 5' ssDNA interaction site; other site 315750007804 metal binding site 3; metal-binding site 315750007805 metal binding site 2 [ion binding]; metal-binding site 315750007806 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315750007807 putative DNA binding site [nucleotide binding]; other site 315750007808 putative metal binding site [ion binding]; other site 315750007809 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 315750007810 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 315750007811 active site 315750007812 DNA binding site [nucleotide binding] 315750007813 catalytic site [active] 315750007814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315750007815 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315750007816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750007817 putative active site [active] 315750007818 heme pocket [chemical binding]; other site 315750007819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750007820 dimer interface [polypeptide binding]; other site 315750007821 phosphorylation site [posttranslational modification] 315750007822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007823 ATP binding site [chemical binding]; other site 315750007824 Mg2+ binding site [ion binding]; other site 315750007825 G-X-G motif; other site 315750007826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750007827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007828 active site 315750007829 phosphorylation site [posttranslational modification] 315750007830 intermolecular recognition site; other site 315750007831 dimerization interface [polypeptide binding]; other site 315750007832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750007833 DNA binding site [nucleotide binding] 315750007834 malate dehydrogenase; Reviewed; Region: PRK06223 315750007835 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 315750007836 NAD(P) binding site [chemical binding]; other site 315750007837 dimer interface [polypeptide binding]; other site 315750007838 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750007839 substrate binding site [chemical binding]; other site 315750007840 isocitrate dehydrogenase; Reviewed; Region: PRK07006 315750007841 isocitrate dehydrogenase; Validated; Region: PRK07362 315750007842 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 315750007843 dimer interface [polypeptide binding]; other site 315750007844 Citrate synthase; Region: Citrate_synt; pfam00285 315750007845 active site 315750007846 citrylCoA binding site [chemical binding]; other site 315750007847 oxalacetate/citrate binding site [chemical binding]; other site 315750007848 coenzyme A binding site [chemical binding]; other site 315750007849 catalytic triad [active] 315750007850 Protein of unknown function (DUF441); Region: DUF441; pfam04284 315750007851 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 315750007852 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750007853 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 315750007854 pyruvate kinase; Provisional; Region: PRK06354 315750007855 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 315750007856 domain interfaces; other site 315750007857 active site 315750007858 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 315750007859 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 315750007860 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 315750007861 active site 315750007862 ADP/pyrophosphate binding site [chemical binding]; other site 315750007863 dimerization interface [polypeptide binding]; other site 315750007864 allosteric effector site; other site 315750007865 fructose-1,6-bisphosphate binding site; other site 315750007866 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 315750007867 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315750007868 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 315750007869 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 315750007870 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 315750007871 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315750007872 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 315750007873 putative NAD(P) binding site [chemical binding]; other site 315750007874 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 315750007875 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 315750007876 active site 315750007877 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 315750007878 generic binding surface I; other site 315750007879 generic binding surface II; other site 315750007880 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 315750007881 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 315750007882 DHH family; Region: DHH; pfam01368 315750007883 DHHA1 domain; Region: DHHA1; pfam02272 315750007884 YtpI-like protein; Region: YtpI; pfam14007 315750007885 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 315750007886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 315750007887 DNA-binding site [nucleotide binding]; DNA binding site 315750007888 DRTGG domain; Region: DRTGG; pfam07085 315750007889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 315750007890 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 315750007891 active site 2 [active] 315750007892 active site 1 [active] 315750007893 metal-dependent hydrolase; Provisional; Region: PRK00685 315750007894 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 315750007895 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 315750007896 classical (c) SDRs; Region: SDR_c; cd05233 315750007897 NAD(P) binding site [chemical binding]; other site 315750007898 active site 315750007899 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315750007900 Phosphotransferase enzyme family; Region: APH; pfam01636 315750007901 active site 315750007902 ATP binding site [chemical binding]; other site 315750007903 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315750007904 active site 315750007905 ATP binding site [chemical binding]; other site 315750007906 argininosuccinate lyase; Provisional; Region: PRK00855 315750007907 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 315750007908 active sites [active] 315750007909 tetramer interface [polypeptide binding]; other site 315750007910 argininosuccinate synthase; Provisional; Region: PRK13820 315750007911 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 315750007912 ANP binding site [chemical binding]; other site 315750007913 Substrate Binding Site II [chemical binding]; other site 315750007914 Substrate Binding Site I [chemical binding]; other site 315750007915 propionate/acetate kinase; Provisional; Region: PRK12379 315750007916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750007917 nucleotide binding site [chemical binding]; other site 315750007918 butyrate kinase; Provisional; Region: PRK03011 315750007919 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 315750007920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750007921 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 315750007922 dimer interface [polypeptide binding]; other site 315750007923 catalytic triad [active] 315750007924 peroxidatic and resolving cysteines [active] 315750007925 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 315750007926 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 315750007927 RDD family; Region: RDD; pfam06271 315750007928 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 315750007929 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 315750007930 tandem repeat interface [polypeptide binding]; other site 315750007931 oligomer interface [polypeptide binding]; other site 315750007932 active site residues [active] 315750007933 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 315750007934 ATP-NAD kinase; Region: NAD_kinase; pfam01513 315750007935 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 315750007936 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750007937 ATP binding site [chemical binding]; other site 315750007938 Mg++ binding site [ion binding]; other site 315750007939 motif III; other site 315750007940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750007941 nucleotide binding region [chemical binding]; other site 315750007942 ATP-binding site [chemical binding]; other site 315750007943 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 315750007944 RNA binding site [nucleotide binding]; other site 315750007945 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 315750007946 Fatty acid desaturase; Region: FA_desaturase; pfam00487 315750007947 putative di-iron ligands [ion binding]; other site 315750007948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750007949 Histidine kinase; Region: HisKA_3; pfam07730 315750007950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007951 ATP binding site [chemical binding]; other site 315750007952 Mg2+ binding site [ion binding]; other site 315750007953 G-X-G motif; other site 315750007954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750007955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007956 active site 315750007957 phosphorylation site [posttranslational modification] 315750007958 intermolecular recognition site; other site 315750007959 dimerization interface [polypeptide binding]; other site 315750007960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750007961 DNA binding residues [nucleotide binding] 315750007962 dimerization interface [polypeptide binding]; other site 315750007963 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750007964 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750007965 putative ligand binding residues [chemical binding]; other site 315750007966 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750007967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007968 active site 315750007969 phosphorylation site [posttranslational modification] 315750007970 intermolecular recognition site; other site 315750007971 dimerization interface [polypeptide binding]; other site 315750007972 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750007973 DNA binding site [nucleotide binding] 315750007974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750007975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007976 ATP binding site [chemical binding]; other site 315750007977 Mg2+ binding site [ion binding]; other site 315750007978 G-X-G motif; other site 315750007979 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750007980 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315750007981 Walker A/P-loop; other site 315750007982 ATP binding site [chemical binding]; other site 315750007983 Q-loop/lid; other site 315750007984 ABC transporter signature motif; other site 315750007985 Walker B; other site 315750007986 D-loop; other site 315750007987 H-loop/switch region; other site 315750007988 FtsX-like permease family; Region: FtsX; pfam02687 315750007989 hypothetical protein; Provisional; Region: PRK08204 315750007990 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750007991 active site 315750007992 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 315750007993 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750007994 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750007995 MarR family; Region: MarR_2; pfam12802 315750007996 Lysine efflux permease [General function prediction only]; Region: COG1279 315750007997 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 315750007998 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 315750007999 active site 315750008000 acyl-activating enzyme (AAE) consensus motif; other site 315750008001 putative CoA binding site [chemical binding]; other site 315750008002 AMP binding site [chemical binding]; other site 315750008003 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750008004 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 315750008005 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 315750008006 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 315750008007 Ligand Binding Site [chemical binding]; other site 315750008008 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315750008009 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315750008010 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 315750008011 histidinol-phosphatase; Reviewed; Region: PRK08123 315750008012 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 315750008013 active site 315750008014 dimer interface [polypeptide binding]; other site 315750008015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750008016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750008017 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 315750008018 GAF domain; Region: GAF_2; pfam13185 315750008019 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 315750008020 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 315750008021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750008022 RNA binding surface [nucleotide binding]; other site 315750008023 Isochorismatase family; Region: Isochorismatase; pfam00857 315750008024 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315750008025 catalytic triad [active] 315750008026 conserved cis-peptide bond; other site 315750008027 Lipase (class 2); Region: Lipase_2; pfam01674 315750008028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750008029 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 315750008030 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 315750008031 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 315750008032 active site 315750008033 HIGH motif; other site 315750008034 dimer interface [polypeptide binding]; other site 315750008035 KMSKS motif; other site 315750008036 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750008037 RNA binding surface [nucleotide binding]; other site 315750008038 acetyl-CoA synthetase; Provisional; Region: PRK04319 315750008039 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315750008040 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 315750008041 active site 315750008042 acyl-activating enzyme (AAE) consensus motif; other site 315750008043 putative CoA binding site [chemical binding]; other site 315750008044 AMP binding site [chemical binding]; other site 315750008045 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315750008046 Coenzyme A binding pocket [chemical binding]; other site 315750008047 FOG: CBS domain [General function prediction only]; Region: COG0517 315750008048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 315750008049 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 315750008050 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 315750008051 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 315750008052 active site 315750008053 Zn binding site [ion binding]; other site 315750008054 catabolite control protein A; Region: ccpA; TIGR01481 315750008055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750008056 DNA binding site [nucleotide binding] 315750008057 domain linker motif; other site 315750008058 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 315750008059 dimerization interface [polypeptide binding]; other site 315750008060 effector binding site; other site 315750008061 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 315750008062 Chorismate mutase type II; Region: CM_2; cl00693 315750008063 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 315750008064 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 315750008065 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 315750008066 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 315750008067 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 315750008068 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315750008069 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750008070 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750008071 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315750008072 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315750008073 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 315750008074 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315750008075 putative tRNA-binding site [nucleotide binding]; other site 315750008076 hypothetical protein; Provisional; Region: PRK13668 315750008077 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750008078 catalytic residues [active] 315750008079 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 315750008080 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 315750008081 YtoQ family protein; Region: YtoQ_fam; TIGR03646 315750008082 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315750008083 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315750008084 oligomer interface [polypeptide binding]; other site 315750008085 active site 315750008086 metal binding site [ion binding]; metal-binding site 315750008087 Predicted small secreted protein [Function unknown]; Region: COG5584 315750008088 malate dehydrogenase; Provisional; Region: PRK13529 315750008089 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315750008090 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 315750008091 NAD(P) binding site [chemical binding]; other site 315750008092 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315750008093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750008094 S-adenosylmethionine binding site [chemical binding]; other site 315750008095 YtzH-like protein; Region: YtzH; pfam14165 315750008096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315750008097 Phosphotransferase enzyme family; Region: APH; pfam01636 315750008098 active site 315750008099 substrate binding site [chemical binding]; other site 315750008100 ATP binding site [chemical binding]; other site 315750008101 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 315750008102 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 315750008103 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 315750008104 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315750008105 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315750008106 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315750008107 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315750008108 dimer interface [polypeptide binding]; other site 315750008109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008110 catalytic residue [active] 315750008111 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 315750008112 conserved cys residue [active] 315750008113 dipeptidase PepV; Reviewed; Region: PRK07318 315750008114 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 315750008115 active site 315750008116 metal binding site [ion binding]; metal-binding site 315750008117 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315750008118 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315750008119 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 315750008120 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315750008121 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750008122 RNA binding surface [nucleotide binding]; other site 315750008123 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 315750008124 active site 315750008125 uracil binding [chemical binding]; other site 315750008126 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315750008127 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315750008128 HI0933-like protein; Region: HI0933_like; pfam03486 315750008129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750008130 BCCT family transporter; Region: BCCT; pfam02028 315750008131 Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691 315750008132 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 315750008133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750008134 active site residue [active] 315750008135 Predicted integral membrane protein [Function unknown]; Region: COG5578 315750008136 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315750008137 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315750008138 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 315750008139 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 315750008140 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750008141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008142 ABC-ATPase subunit interface; other site 315750008143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750008144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750008145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750008146 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750008147 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315750008148 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750008149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750008150 putative substrate translocation pore; other site 315750008151 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750008152 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750008153 active site 315750008154 catalytic tetrad [active] 315750008155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315750008156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 315750008157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750008158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008159 dimer interface [polypeptide binding]; other site 315750008160 conserved gate region; other site 315750008161 putative PBP binding loops; other site 315750008162 ABC-ATPase subunit interface; other site 315750008163 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315750008164 extended (e) SDRs; Region: SDR_e; cd08946 315750008165 NAD(P) binding site [chemical binding]; other site 315750008166 substrate binding site [chemical binding]; other site 315750008167 active site 315750008168 Abhydrolase family; Region: Abhydrolase_7; pfam12715 315750008169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750008170 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 315750008171 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315750008172 HIGH motif; other site 315750008173 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315750008174 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315750008175 active site 315750008176 KMSKS motif; other site 315750008177 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 315750008178 tRNA binding surface [nucleotide binding]; other site 315750008179 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 315750008180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750008181 PAS domain; Region: PAS_9; pfam13426 315750008182 putative active site [active] 315750008183 heme pocket [chemical binding]; other site 315750008184 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750008185 Predicted membrane protein [Function unknown]; Region: COG3374 315750008186 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 315750008187 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315750008188 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315750008189 FtsX-like permease family; Region: FtsX; pfam02687 315750008190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750008191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315750008192 Walker A/P-loop; other site 315750008193 ATP binding site [chemical binding]; other site 315750008194 Q-loop/lid; other site 315750008195 ABC transporter signature motif; other site 315750008196 Walker B; other site 315750008197 D-loop; other site 315750008198 H-loop/switch region; other site 315750008199 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 315750008200 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315750008201 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750008202 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750008203 Walker A/P-loop; other site 315750008204 ATP binding site [chemical binding]; other site 315750008205 Q-loop/lid; other site 315750008206 ABC transporter signature motif; other site 315750008207 Walker B; other site 315750008208 D-loop; other site 315750008209 H-loop/switch region; other site 315750008210 Predicted transcriptional regulators [Transcription]; Region: COG1725 315750008211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750008212 DNA-binding site [nucleotide binding]; DNA binding site 315750008213 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 315750008214 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 315750008215 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315750008216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750008217 S-adenosylmethionine binding site [chemical binding]; other site 315750008218 Beta2-adaptin appendage, C-terminal sub-domain; Region: B2-adapt-app_C; cl07618 315750008219 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 315750008220 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315750008221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315750008222 PGAP1-like protein; Region: PGAP1; pfam07819 315750008223 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 315750008224 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 315750008225 trimer interface [polypeptide binding]; other site 315750008226 putative metal binding site [ion binding]; other site 315750008227 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 315750008228 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315750008229 active site 315750008230 dimer interface [polypeptide binding]; other site 315750008231 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315750008232 Ligand Binding Site [chemical binding]; other site 315750008233 Molecular Tunnel; other site 315750008234 S-adenosylmethionine synthetase; Validated; Region: PRK05250 315750008235 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 315750008236 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 315750008237 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 315750008238 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 315750008239 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 315750008240 active site 315750008241 substrate-binding site [chemical binding]; other site 315750008242 metal-binding site [ion binding] 315750008243 ATP binding site [chemical binding]; other site 315750008244 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 315750008245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750008246 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315750008247 phytoene desaturase; Region: crtI_fam; TIGR02734 315750008248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315750008249 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 315750008250 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750008251 active site 315750008252 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 315750008253 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 315750008254 putative acyl-acceptor binding pocket; other site 315750008255 Protein of unknown function (DUF422); Region: DUF422; cl00991 315750008256 NMT1-like family; Region: NMT1_2; pfam13379 315750008257 NMT1/THI5 like; Region: NMT1; pfam09084 315750008258 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315750008259 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 315750008260 Walker A/P-loop; other site 315750008261 ATP binding site [chemical binding]; other site 315750008262 Q-loop/lid; other site 315750008263 ABC transporter signature motif; other site 315750008264 Walker B; other site 315750008265 D-loop; other site 315750008266 H-loop/switch region; other site 315750008267 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 315750008268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008269 dimer interface [polypeptide binding]; other site 315750008270 conserved gate region; other site 315750008271 putative PBP binding loops; other site 315750008272 ABC-ATPase subunit interface; other site 315750008273 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 315750008274 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 315750008275 nudix motif; other site 315750008276 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750008277 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750008278 putative metal binding site [ion binding]; other site 315750008279 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 315750008280 Holin family; Region: Phage_holin_4; cl01989 315750008281 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 315750008282 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 315750008283 dimerization interface [polypeptide binding]; other site 315750008284 DPS ferroxidase diiron center [ion binding]; other site 315750008285 ion pore; other site 315750008286 YtkA-like; Region: YtkA; pfam13115 315750008287 S-ribosylhomocysteinase; Provisional; Region: PRK02260 315750008288 Haemolytic domain; Region: Haemolytic; pfam01809 315750008289 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315750008290 active site clefts [active] 315750008291 zinc binding site [ion binding]; other site 315750008292 dimer interface [polypeptide binding]; other site 315750008293 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 315750008294 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 315750008295 metal binding site [ion binding]; metal-binding site 315750008296 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 315750008297 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 315750008298 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 315750008299 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315750008300 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 315750008301 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 315750008302 active site 315750008303 octamer interface [polypeptide binding]; other site 315750008304 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 315750008305 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 315750008306 acyl-activating enzyme (AAE) consensus motif; other site 315750008307 putative AMP binding site [chemical binding]; other site 315750008308 putative active site [active] 315750008309 putative CoA binding site [chemical binding]; other site 315750008310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750008311 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 315750008312 substrate binding site [chemical binding]; other site 315750008313 oxyanion hole (OAH) forming residues; other site 315750008314 trimer interface [polypeptide binding]; other site 315750008315 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 315750008316 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 315750008317 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 315750008318 dimer interface [polypeptide binding]; other site 315750008319 tetramer interface [polypeptide binding]; other site 315750008320 PYR/PP interface [polypeptide binding]; other site 315750008321 TPP binding site [chemical binding]; other site 315750008322 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 315750008323 TPP-binding site; other site 315750008324 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 315750008325 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315750008326 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 315750008327 UbiA prenyltransferase family; Region: UbiA; pfam01040 315750008328 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315750008329 TspO/MBR family; Region: TspO_MBR; pfam03073 315750008330 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 315750008331 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315750008332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750008333 Coenzyme A binding pocket [chemical binding]; other site 315750008334 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 315750008335 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 315750008336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 315750008337 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 315750008338 metal-dependent hydrolase; Provisional; Region: PRK13291 315750008339 DinB superfamily; Region: DinB_2; pfam12867 315750008340 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315750008341 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 315750008342 active site 315750008343 NAD binding site [chemical binding]; other site 315750008344 metal binding site [ion binding]; metal-binding site 315750008345 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 315750008346 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 315750008347 tetramerization interface [polypeptide binding]; other site 315750008348 NAD(P) binding site [chemical binding]; other site 315750008349 catalytic residues [active] 315750008350 Predicted transcriptional regulators [Transcription]; Region: COG1510 315750008351 MarR family; Region: MarR_2; pfam12802 315750008352 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315750008353 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 315750008354 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 315750008355 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315750008356 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 315750008357 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750008358 holin, SPP1 family; Region: holin_SPP1; TIGR01592 315750008359 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 315750008360 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 315750008361 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 315750008362 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 315750008363 XkdW protein; Region: XkdW; pfam09636 315750008364 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 315750008365 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 315750008366 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 315750008367 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 315750008368 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 315750008369 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 315750008370 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750008371 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315750008372 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750008373 catalytic residue [active] 315750008374 Phage XkdN-like protein; Region: XkdN; pfam08890 315750008375 similar to hypothetical protein 315750008376 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 315750008377 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 315750008378 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 315750008379 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 315750008380 Phage capsid family; Region: Phage_capsid; pfam05065 315750008381 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 315750008382 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 315750008383 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 315750008384 Terminase-like family; Region: Terminase_6; pfam03237 315750008385 Uncharacterized conserved protein [Function unknown]; Region: COG5484 315750008386 Homeodomain-like domain; Region: HTH_23; pfam13384 315750008387 positive control sigma-like factor; Validated; Region: PRK06930 315750008388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750008389 DNA binding residues [nucleotide binding] 315750008390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750008391 non-specific DNA binding site [nucleotide binding]; other site 315750008392 salt bridge; other site 315750008393 sequence-specific DNA binding site [nucleotide binding]; other site 315750008394 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750008395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750008396 non-specific DNA binding site [nucleotide binding]; other site 315750008397 salt bridge; other site 315750008398 sequence-specific DNA binding site [nucleotide binding]; other site 315750008399 biotin synthase; Validated; Region: PRK06256 315750008400 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750008401 FeS/SAM binding site; other site 315750008402 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 315750008403 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 315750008404 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315750008405 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750008406 Predicted membrane protein [Function unknown]; Region: COG4270 315750008407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315750008408 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315750008409 intracellular protease, PfpI family; Region: PfpI; TIGR01382 315750008410 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 315750008411 proposed catalytic triad [active] 315750008412 conserved cys residue [active] 315750008413 Tar ligand binding domain homologue; Region: TarH; pfam02203 315750008414 Cache domain; Region: Cache_1; pfam02743 315750008415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008416 dimerization interface [polypeptide binding]; other site 315750008417 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008419 dimer interface [polypeptide binding]; other site 315750008420 putative CheW interface [polypeptide binding]; other site 315750008421 Cache domain; Region: Cache_1; pfam02743 315750008422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008423 dimerization interface [polypeptide binding]; other site 315750008424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008425 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008426 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008427 dimer interface [polypeptide binding]; other site 315750008428 putative CheW interface [polypeptide binding]; other site 315750008429 Tar ligand binding domain homologue; Region: TarH; pfam02203 315750008430 Cache domain; Region: Cache_1; pfam02743 315750008431 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315750008432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008433 dimerization interface [polypeptide binding]; other site 315750008434 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008435 dimer interface [polypeptide binding]; other site 315750008436 putative CheW interface [polypeptide binding]; other site 315750008437 Tar ligand binding domain homologue; Region: TarH; pfam02203 315750008438 Cache domain; Region: Cache_1; pfam02743 315750008439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008440 dimerization interface [polypeptide binding]; other site 315750008441 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008443 dimer interface [polypeptide binding]; other site 315750008444 putative CheW interface [polypeptide binding]; other site 315750008445 transglutaminase; Provisional; Region: tgl; PRK03187 315750008446 Nitronate monooxygenase; Region: NMO; pfam03060 315750008447 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 315750008448 FMN binding site [chemical binding]; other site 315750008449 substrate binding site [chemical binding]; other site 315750008450 putative catalytic residue [active] 315750008451 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 315750008452 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315750008453 Domain of unknown function DUF21; Region: DUF21; pfam01595 315750008454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315750008455 Transporter associated domain; Region: CorC_HlyC; smart01091 315750008456 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 315750008457 Ion transport protein; Region: Ion_trans; pfam00520 315750008458 Ion channel; Region: Ion_trans_2; pfam07885 315750008459 TrkA-N domain; Region: TrkA_N; pfam02254 315750008460 YugN-like family; Region: YugN; pfam08868 315750008461 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750008462 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 315750008463 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 315750008464 active site 315750008465 dimer interface [polypeptide binding]; other site 315750008466 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 315750008467 dimer interface [polypeptide binding]; other site 315750008468 active site 315750008469 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 315750008470 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 315750008471 dimer interface [polypeptide binding]; other site 315750008472 active site 315750008473 metal binding site [ion binding]; metal-binding site 315750008474 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 315750008475 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 315750008476 dimer interface [polypeptide binding]; other site 315750008477 active site 315750008478 metal binding site [ion binding]; metal-binding site 315750008479 Uncharacterized conserved protein [Function unknown]; Region: COG2155 315750008480 general stress protein 13; Validated; Region: PRK08059 315750008481 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 315750008482 RNA binding site [nucleotide binding]; other site 315750008483 Global regulator protein family; Region: CsrA; cl00670 315750008484 hypothetical protein; Validated; Region: PRK07682 315750008485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750008486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008487 homodimer interface [polypeptide binding]; other site 315750008488 catalytic residue [active] 315750008489 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315750008490 AsnC family; Region: AsnC_trans_reg; pfam01037 315750008491 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 315750008492 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750008493 nucleophilic elbow; other site 315750008494 catalytic triad; other site 315750008495 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 315750008496 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 315750008497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750008498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008499 homodimer interface [polypeptide binding]; other site 315750008500 catalytic residue [active] 315750008501 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315750008502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008504 dimer interface [polypeptide binding]; other site 315750008505 phosphorylation site [posttranslational modification] 315750008506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008507 ATP binding site [chemical binding]; other site 315750008508 Mg2+ binding site [ion binding]; other site 315750008509 G-X-G motif; other site 315750008510 Kinase associated protein B; Region: KapB; pfam08810 315750008511 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 315750008512 active site 315750008513 catalytic site [active] 315750008514 substrate binding site [chemical binding]; other site 315750008515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750008516 drug efflux system protein MdtG; Provisional; Region: PRK09874 315750008517 putative substrate translocation pore; other site 315750008518 Transglycosylase; Region: Transgly; pfam00912 315750008519 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750008520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 315750008521 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 315750008522 sensory histidine kinase DcuS; Provisional; Region: PRK11086 315750008523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008524 ATP binding site [chemical binding]; other site 315750008525 Mg2+ binding site [ion binding]; other site 315750008526 G-X-G motif; other site 315750008527 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315750008528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008529 active site 315750008530 phosphorylation site [posttranslational modification] 315750008531 intermolecular recognition site; other site 315750008532 dimerization interface [polypeptide binding]; other site 315750008533 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 315750008534 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 315750008535 ligand binding site [chemical binding]; other site 315750008536 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 315750008537 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315750008538 Walker A/P-loop; other site 315750008539 ATP binding site [chemical binding]; other site 315750008540 Q-loop/lid; other site 315750008541 ABC transporter signature motif; other site 315750008542 Walker B; other site 315750008543 D-loop; other site 315750008544 H-loop/switch region; other site 315750008545 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315750008546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315750008547 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315750008548 TM-ABC transporter signature motif; other site 315750008549 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315750008550 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315750008551 TM-ABC transporter signature motif; other site 315750008552 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 315750008553 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 315750008554 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 315750008555 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 315750008556 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 315750008557 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 315750008558 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 315750008559 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 315750008560 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 315750008561 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 315750008562 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 315750008563 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 315750008564 CoenzymeA binding site [chemical binding]; other site 315750008565 subunit interaction site [polypeptide binding]; other site 315750008566 PHB binding site; other site 315750008567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750008568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008569 active site 315750008570 phosphorylation site [posttranslational modification] 315750008571 intermolecular recognition site; other site 315750008572 dimerization interface [polypeptide binding]; other site 315750008573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750008574 DNA binding residues [nucleotide binding] 315750008575 dimerization interface [polypeptide binding]; other site 315750008576 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750008577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750008578 Histidine kinase; Region: HisKA_3; pfam07730 315750008579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008580 ATP binding site [chemical binding]; other site 315750008581 Mg2+ binding site [ion binding]; other site 315750008582 G-X-G motif; other site 315750008583 Bacillus competence pheromone ComX; Region: ComX; pfam05952 315750008584 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 315750008585 aspartate-rich region 2; other site 315750008586 DegQ (SacQ) family; Region: DegQ; pfam08181 315750008587 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 315750008588 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315750008589 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 315750008590 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 315750008591 active site 315750008592 Isochorismatase family; Region: Isochorismatase; pfam00857 315750008593 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315750008594 catalytic triad [active] 315750008595 conserved cis-peptide bond; other site 315750008596 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 315750008597 YueH-like protein; Region: YueH; pfam14166 315750008598 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750008599 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750008600 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315750008601 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750008602 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 315750008603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315750008604 PGAP1-like protein; Region: PGAP1; pfam07819 315750008605 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 315750008606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750008607 Zn2+ binding site [ion binding]; other site 315750008608 Mg2+ binding site [ion binding]; other site 315750008609 short chain dehydrogenase; Provisional; Region: PRK06924 315750008610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008611 NAD(P) binding site [chemical binding]; other site 315750008612 active site 315750008613 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 315750008614 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315750008615 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 315750008616 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 315750008617 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750008618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750008619 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 315750008620 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 315750008621 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315750008622 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315750008623 Domain of unknown function DUF87; Region: DUF87; pfam01935 315750008624 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 315750008625 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 315750008626 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 315750008627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 315750008628 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315750008629 CodY GAF-like domain; Region: CodY; pfam06018 315750008630 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750008631 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315750008632 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 315750008633 hexamer interface [polypeptide binding]; other site 315750008634 ligand binding site [chemical binding]; other site 315750008635 putative active site [active] 315750008636 NAD(P) binding site [chemical binding]; other site 315750008637 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 315750008638 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 315750008639 SpoOM protein; Region: Spo0M; pfam07070 315750008640 Predicted permease [General function prediction only]; Region: COG2056 315750008641 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 315750008642 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 315750008643 multifunctional aminopeptidase A; Provisional; Region: PRK00913 315750008644 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 315750008645 interface (dimer of trimers) [polypeptide binding]; other site 315750008646 Substrate-binding/catalytic site; other site 315750008647 Zn-binding sites [ion binding]; other site 315750008648 Divergent PAP2 family; Region: DUF212; pfam02681 315750008649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315750008650 Putative membrane protein; Region: YuiB; pfam14068 315750008651 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 315750008652 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315750008653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008654 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315750008655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750008656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008657 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 315750008658 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 315750008659 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 315750008660 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 315750008661 hypothetical protein; Provisional; Region: PRK13669 315750008662 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315750008663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008664 WYL domain; Region: WYL; cl14852 315750008665 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 315750008666 NifU-like domain; Region: NifU; pfam01106 315750008667 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 315750008668 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315750008669 homoserine kinase; Provisional; Region: PRK01212 315750008670 threonine synthase; Reviewed; Region: PRK06721 315750008671 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 315750008672 homodimer interface [polypeptide binding]; other site 315750008673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008674 catalytic residue [active] 315750008675 homoserine dehydrogenase; Provisional; Region: PRK06349 315750008676 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 315750008677 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315750008678 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 315750008679 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 315750008680 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 315750008681 dimerization interface [polypeptide binding]; other site 315750008682 ligand binding site [chemical binding]; other site 315750008683 NADP binding site [chemical binding]; other site 315750008684 catalytic site [active] 315750008685 spore coat protein YutH; Region: spore_yutH; TIGR02905 315750008686 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 315750008687 tetramer interfaces [polypeptide binding]; other site 315750008688 binuclear metal-binding site [ion binding]; other site 315750008689 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 315750008690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750008691 active site 315750008692 motif I; other site 315750008693 motif II; other site 315750008694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750008695 Uncharacterized conserved protein [Function unknown]; Region: COG2445 315750008696 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 315750008697 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750008698 lipoyl synthase; Provisional; Region: PRK05481 315750008699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750008700 FeS/SAM binding site; other site 315750008701 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315750008702 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750008703 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 315750008704 Uncharacterized conserved protein [Function unknown]; Region: COG3377 315750008705 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315750008706 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 315750008707 active site 315750008708 metal binding site [ion binding]; metal-binding site 315750008709 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750008710 Uncharacterized conserved protein [Function unknown]; Region: COG1801 315750008711 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315750008712 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750008713 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 315750008714 Cupin; Region: Cupin_1; smart00835 315750008715 Cupin; Region: Cupin_1; smart00835 315750008716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750008717 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750008718 putative substrate translocation pore; other site 315750008719 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 315750008720 homodimer interface [polypeptide binding]; other site 315750008721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008722 catalytic residue [active] 315750008723 Endonuclease I; Region: Endonuclease_1; pfam04231 315750008724 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 315750008725 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315750008726 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 315750008727 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008729 ABC-ATPase subunit interface; other site 315750008730 dimer interface [polypeptide binding]; other site 315750008731 putative PBP binding regions; other site 315750008732 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008734 ABC-ATPase subunit interface; other site 315750008735 dimer interface [polypeptide binding]; other site 315750008736 putative PBP binding regions; other site 315750008737 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315750008738 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750008739 siderophore binding site; other site 315750008740 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315750008741 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315750008742 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 315750008743 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315750008744 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 315750008745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008746 HAMP domain; Region: HAMP; pfam00672 315750008747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008748 dimer interface [polypeptide binding]; other site 315750008749 phosphorylation site [posttranslational modification] 315750008750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750008751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008752 active site 315750008753 phosphorylation site [posttranslational modification] 315750008754 intermolecular recognition site; other site 315750008755 dimerization interface [polypeptide binding]; other site 315750008756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750008757 DNA binding site [nucleotide binding] 315750008758 Predicted membrane protein [Function unknown]; Region: COG2311 315750008759 Protein of unknown function (DUF418); Region: DUF418; cl12135 315750008760 Protein of unknown function (DUF418); Region: DUF418; pfam04235 315750008761 Predicted transcriptional regulator [Transcription]; Region: COG2378 315750008762 HTH domain; Region: HTH_11; pfam08279 315750008763 WYL domain; Region: WYL; pfam13280 315750008764 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 315750008765 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750008766 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 315750008767 FeS assembly protein SufB; Region: sufB; TIGR01980 315750008768 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 315750008769 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 315750008770 trimerization site [polypeptide binding]; other site 315750008771 active site 315750008772 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 315750008773 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 315750008774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315750008775 catalytic residue [active] 315750008776 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 315750008777 FeS assembly protein SufD; Region: sufD; TIGR01981 315750008778 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 315750008779 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 315750008780 Walker A/P-loop; other site 315750008781 ATP binding site [chemical binding]; other site 315750008782 Q-loop/lid; other site 315750008783 ABC transporter signature motif; other site 315750008784 Walker B; other site 315750008785 D-loop; other site 315750008786 H-loop/switch region; other site 315750008787 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 315750008788 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 315750008789 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 315750008790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008791 dimer interface [polypeptide binding]; other site 315750008792 conserved gate region; other site 315750008793 ABC-ATPase subunit interface; other site 315750008794 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 315750008795 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 315750008796 Walker A/P-loop; other site 315750008797 ATP binding site [chemical binding]; other site 315750008798 Q-loop/lid; other site 315750008799 ABC transporter signature motif; other site 315750008800 Walker B; other site 315750008801 D-loop; other site 315750008802 H-loop/switch region; other site 315750008803 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 315750008804 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 315750008805 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750008806 catalytic residues [active] 315750008807 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 315750008808 active site 315750008809 metal binding site [ion binding]; metal-binding site 315750008810 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 315750008811 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 315750008812 lipoyl attachment site [posttranslational modification]; other site 315750008813 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 315750008814 ArsC family; Region: ArsC; pfam03960 315750008815 putative ArsC-like catalytic residues; other site 315750008816 putative TRX-like catalytic residues [active] 315750008817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315750008818 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750008819 active site 315750008820 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 315750008821 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315750008822 dimer interface [polypeptide binding]; other site 315750008823 active site 315750008824 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 315750008825 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 315750008826 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750008827 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750008828 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 315750008829 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750008830 substrate binding site [chemical binding]; other site 315750008831 oxyanion hole (OAH) forming residues; other site 315750008832 trimer interface [polypeptide binding]; other site 315750008833 YuzL-like protein; Region: YuzL; pfam14115 315750008834 Coat F domain; Region: Coat_F; pfam07875 315750008835 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 315750008836 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750008837 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750008838 Walker A/P-loop; other site 315750008839 ATP binding site [chemical binding]; other site 315750008840 Q-loop/lid; other site 315750008841 ABC transporter signature motif; other site 315750008842 Walker B; other site 315750008843 D-loop; other site 315750008844 H-loop/switch region; other site 315750008845 YusW-like protein; Region: YusW; pfam14039 315750008846 short chain dehydrogenase; Provisional; Region: PRK06914 315750008847 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 315750008848 NADP binding site [chemical binding]; other site 315750008849 active site 315750008850 steroid binding site; other site 315750008851 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315750008852 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 315750008853 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750008854 protein binding site [polypeptide binding]; other site 315750008855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750008856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008857 active site 315750008858 phosphorylation site [posttranslational modification] 315750008859 intermolecular recognition site; other site 315750008860 dimerization interface [polypeptide binding]; other site 315750008861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750008862 DNA binding site [nucleotide binding] 315750008863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008865 dimerization interface [polypeptide binding]; other site 315750008866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008867 dimer interface [polypeptide binding]; other site 315750008868 phosphorylation site [posttranslational modification] 315750008869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008870 ATP binding site [chemical binding]; other site 315750008871 Mg2+ binding site [ion binding]; other site 315750008872 G-X-G motif; other site 315750008873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750008874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750008875 fumarate hydratase; Reviewed; Region: fumC; PRK00485 315750008876 Class II fumarases; Region: Fumarase_classII; cd01362 315750008877 active site 315750008878 tetramer interface [polypeptide binding]; other site 315750008879 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 315750008880 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750008881 Spore germination protein; Region: Spore_permease; cl17796 315750008882 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315750008883 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315750008884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750008885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008886 active site 315750008887 phosphorylation site [posttranslational modification] 315750008888 intermolecular recognition site; other site 315750008889 dimerization interface [polypeptide binding]; other site 315750008890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750008891 DNA binding residues [nucleotide binding] 315750008892 dimerization interface [polypeptide binding]; other site 315750008893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750008894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008895 dimerization interface [polypeptide binding]; other site 315750008896 Histidine kinase; Region: HisKA_3; pfam07730 315750008897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008898 ATP binding site [chemical binding]; other site 315750008899 Mg2+ binding site [ion binding]; other site 315750008900 G-X-G motif; other site 315750008901 Predicted membrane protein [Function unknown]; Region: COG4758 315750008902 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 315750008903 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 315750008904 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 315750008905 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315750008906 PspA/IM30 family; Region: PspA_IM30; pfam04012 315750008907 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 315750008908 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750008909 classical (c) SDRs; Region: SDR_c; cd05233 315750008910 NAD(P) binding site [chemical binding]; other site 315750008911 active site 315750008912 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 315750008913 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 315750008914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 315750008915 Propionate catabolism activator; Region: PrpR_N; pfam06506 315750008916 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315750008917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750008918 Walker A motif; other site 315750008919 ATP binding site [chemical binding]; other site 315750008920 Walker B motif; other site 315750008921 arginine finger; other site 315750008922 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315750008923 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 315750008924 BNR repeat-like domain; Region: BNR_2; pfam13088 315750008925 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 315750008926 Na binding site [ion binding]; other site 315750008927 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 315750008928 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315750008929 putative active site [active] 315750008930 metal binding site [ion binding]; metal-binding site 315750008931 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 315750008932 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 315750008933 inhibitor site; inhibition site 315750008934 active site 315750008935 dimer interface [polypeptide binding]; other site 315750008936 catalytic residue [active] 315750008937 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750008938 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750008939 Walker A/P-loop; other site 315750008940 ATP binding site [chemical binding]; other site 315750008941 Q-loop/lid; other site 315750008942 ABC transporter signature motif; other site 315750008943 Walker B; other site 315750008944 D-loop; other site 315750008945 H-loop/switch region; other site 315750008946 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008948 dimer interface [polypeptide binding]; other site 315750008949 ABC-ATPase subunit interface; other site 315750008950 putative PBP binding regions; other site 315750008951 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750008952 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 315750008953 putative binding site residues; other site 315750008954 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 315750008955 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 315750008956 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 315750008957 galactarate dehydratase; Region: galactar-dH20; TIGR03248 315750008958 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 315750008959 altronate oxidoreductase; Provisional; Region: PRK03643 315750008960 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 315750008961 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 315750008962 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750008963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750008964 DNA binding site [nucleotide binding] 315750008965 domain linker motif; other site 315750008966 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 315750008967 dimerization interface [polypeptide binding]; other site 315750008968 ligand binding site [chemical binding]; other site 315750008969 Glucuronate isomerase; Region: UxaC; pfam02614 315750008970 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 315750008971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008973 dimer interface [polypeptide binding]; other site 315750008974 phosphorylation site [posttranslational modification] 315750008975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008976 ATP binding site [chemical binding]; other site 315750008977 Mg2+ binding site [ion binding]; other site 315750008978 G-X-G motif; other site 315750008979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750008980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008981 active site 315750008982 phosphorylation site [posttranslational modification] 315750008983 intermolecular recognition site; other site 315750008984 dimerization interface [polypeptide binding]; other site 315750008985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750008986 DNA binding site [nucleotide binding] 315750008987 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750008988 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750008989 Walker A/P-loop; other site 315750008990 ATP binding site [chemical binding]; other site 315750008991 Q-loop/lid; other site 315750008992 ABC transporter signature motif; other site 315750008993 Walker B; other site 315750008994 D-loop; other site 315750008995 H-loop/switch region; other site 315750008996 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008997 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008998 ABC-ATPase subunit interface; other site 315750008999 dimer interface [polypeptide binding]; other site 315750009000 putative PBP binding regions; other site 315750009001 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750009002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750009003 ABC-ATPase subunit interface; other site 315750009004 dimer interface [polypeptide binding]; other site 315750009005 putative PBP binding regions; other site 315750009006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750009007 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750009008 putative ligand binding residues [chemical binding]; other site 315750009009 arginine:agmatin antiporter; Provisional; Region: PRK10644 315750009010 Spore germination protein; Region: Spore_permease; cl17796 315750009011 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; pfam09575 315750009012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750009013 MarR family; Region: MarR_2; pfam12802 315750009014 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 315750009015 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750009016 Sulfatase; Region: Sulfatase; pfam00884 315750009017 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 315750009018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750009019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750009020 substrate binding pocket [chemical binding]; other site 315750009021 membrane-bound complex binding site; other site 315750009022 hinge residues; other site 315750009023 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 315750009024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009025 dimer interface [polypeptide binding]; other site 315750009026 conserved gate region; other site 315750009027 putative PBP binding loops; other site 315750009028 ABC-ATPase subunit interface; other site 315750009029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750009030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750009031 active site 315750009032 catalytic tetrad [active] 315750009033 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750009034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315750009035 nucleotide binding site [chemical binding]; other site 315750009036 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 315750009037 Predicted membrane protein [Function unknown]; Region: COG2860 315750009038 UPF0126 domain; Region: UPF0126; pfam03458 315750009039 UPF0126 domain; Region: UPF0126; pfam03458 315750009040 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 315750009041 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 315750009042 Thioredoxin; Region: Thioredoxin_4; pfam13462 315750009043 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315750009044 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750009045 metal-binding site [ion binding] 315750009046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750009047 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315750009048 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 315750009049 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 315750009050 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 315750009051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750009052 dimer interface [polypeptide binding]; other site 315750009053 ABC-ATPase subunit interface; other site 315750009054 putative PBP binding regions; other site 315750009055 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 315750009056 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 315750009057 metal binding site [ion binding]; metal-binding site 315750009058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750009059 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 315750009060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009061 Response regulator receiver domain; Region: Response_reg; pfam00072 315750009062 active site 315750009063 phosphorylation site [posttranslational modification] 315750009064 intermolecular recognition site; other site 315750009065 dimerization interface [polypeptide binding]; other site 315750009066 YcbB domain; Region: YcbB; pfam08664 315750009067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750009068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009069 ATP binding site [chemical binding]; other site 315750009070 Mg2+ binding site [ion binding]; other site 315750009071 G-X-G motif; other site 315750009072 aspartate ammonia-lyase; Provisional; Region: PRK13353 315750009073 Aspartase; Region: Aspartase; cd01357 315750009074 active sites [active] 315750009075 tetramer interface [polypeptide binding]; other site 315750009076 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750009077 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750009078 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315750009079 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750009080 metal-binding site [ion binding] 315750009081 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315750009082 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750009083 metal-binding site [ion binding] 315750009084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750009085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009086 motif II; other site 315750009087 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750009088 metal-binding site [ion binding] 315750009089 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 315750009090 putative homodimer interface [polypeptide binding]; other site 315750009091 putative homotetramer interface [polypeptide binding]; other site 315750009092 putative allosteric switch controlling residues; other site 315750009093 putative metal binding site [ion binding]; other site 315750009094 putative homodimer-homodimer interface [polypeptide binding]; other site 315750009095 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cl11617 315750009096 PAS domain; Region: PAS_9; pfam13426 315750009097 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315750009098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750009099 metal binding site [ion binding]; metal-binding site 315750009100 active site 315750009101 I-site; other site 315750009102 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 315750009103 SmpB-tmRNA interface; other site 315750009104 ribonuclease R; Region: RNase_R; TIGR02063 315750009105 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 315750009106 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750009107 RNB domain; Region: RNB; pfam00773 315750009108 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 315750009109 RNA binding site [nucleotide binding]; other site 315750009110 Esterase/lipase [General function prediction only]; Region: COG1647 315750009111 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315750009112 Preprotein translocase SecG subunit; Region: SecG; pfam03840 315750009113 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315750009114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750009115 salt bridge; other site 315750009116 non-specific DNA binding site [nucleotide binding]; other site 315750009117 sequence-specific DNA binding site [nucleotide binding]; other site 315750009118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750009119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750009120 non-specific DNA binding site [nucleotide binding]; other site 315750009121 salt bridge; other site 315750009122 sequence-specific DNA binding site [nucleotide binding]; other site 315750009123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750009124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750009125 non-specific DNA binding site [nucleotide binding]; other site 315750009126 salt bridge; other site 315750009127 sequence-specific DNA binding site [nucleotide binding]; other site 315750009128 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750009129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750009130 putative DNA binding site [nucleotide binding]; other site 315750009131 dimerization interface [polypeptide binding]; other site 315750009132 putative Zn2+ binding site [ion binding]; other site 315750009133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009134 dimer interface [polypeptide binding]; other site 315750009135 conserved gate region; other site 315750009136 putative PBP binding loops; other site 315750009137 ABC-ATPase subunit interface; other site 315750009138 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 315750009139 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 315750009140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009141 dimer interface [polypeptide binding]; other site 315750009142 conserved gate region; other site 315750009143 putative PBP binding loops; other site 315750009144 ABC-ATPase subunit interface; other site 315750009145 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 315750009146 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 315750009147 Walker A/P-loop; other site 315750009148 ATP binding site [chemical binding]; other site 315750009149 Q-loop/lid; other site 315750009150 ABC transporter signature motif; other site 315750009151 Walker B; other site 315750009152 D-loop; other site 315750009153 H-loop/switch region; other site 315750009154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 315750009155 Predicted transcriptional regulators [Transcription]; Region: COG1510 315750009156 MarR family; Region: MarR_2; pfam12802 315750009157 MarC family integral membrane protein; Region: MarC; cl00919 315750009158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750009159 Coenzyme A binding pocket [chemical binding]; other site 315750009160 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750009161 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315750009162 Walker A/P-loop; other site 315750009163 ATP binding site [chemical binding]; other site 315750009164 Q-loop/lid; other site 315750009165 ABC transporter signature motif; other site 315750009166 Walker B; other site 315750009167 D-loop; other site 315750009168 H-loop/switch region; other site 315750009169 enolase; Provisional; Region: eno; PRK00077 315750009170 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 315750009171 dimer interface [polypeptide binding]; other site 315750009172 metal binding site [ion binding]; metal-binding site 315750009173 substrate binding pocket [chemical binding]; other site 315750009174 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 315750009175 phosphoglyceromutase; Provisional; Region: PRK05434 315750009176 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 315750009177 triosephosphate isomerase; Provisional; Region: PRK14565 315750009178 substrate binding site [chemical binding]; other site 315750009179 dimer interface [polypeptide binding]; other site 315750009180 catalytic triad [active] 315750009181 Phosphoglycerate kinase; Region: PGK; pfam00162 315750009182 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 315750009183 substrate binding site [chemical binding]; other site 315750009184 hinge regions; other site 315750009185 ADP binding site [chemical binding]; other site 315750009186 catalytic site [active] 315750009187 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 315750009188 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 315750009189 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 315750009190 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750009191 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750009192 S-methylmethionine transporter; Provisional; Region: PRK11387 315750009193 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 315750009194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750009195 inhibitor-cofactor binding pocket; inhibition site 315750009196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750009197 catalytic residue [active] 315750009198 PAS domain; Region: PAS; smart00091 315750009199 PAS fold; Region: PAS_4; pfam08448 315750009200 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 315750009201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750009202 Walker A motif; other site 315750009203 ATP binding site [chemical binding]; other site 315750009204 Walker B motif; other site 315750009205 arginine finger; other site 315750009206 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315750009207 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315750009208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750009209 DNA-binding site [nucleotide binding]; DNA binding site 315750009210 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 315750009211 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 315750009212 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 315750009213 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 315750009214 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 315750009215 YvfG protein; Region: YvfG; pfam09628 315750009216 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315750009217 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 315750009218 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 315750009219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750009220 Walker A/P-loop; other site 315750009221 ATP binding site [chemical binding]; other site 315750009222 Q-loop/lid; other site 315750009223 ABC transporter signature motif; other site 315750009224 Walker B; other site 315750009225 D-loop; other site 315750009226 H-loop/switch region; other site 315750009227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750009228 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 315750009229 Walker A/P-loop; other site 315750009230 ATP binding site [chemical binding]; other site 315750009231 Q-loop/lid; other site 315750009232 ABC transporter signature motif; other site 315750009233 Walker B; other site 315750009234 D-loop; other site 315750009235 H-loop/switch region; other site 315750009236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750009237 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 315750009238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009239 dimer interface [polypeptide binding]; other site 315750009240 conserved gate region; other site 315750009241 putative PBP binding loops; other site 315750009242 ABC-ATPase subunit interface; other site 315750009243 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 315750009244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009245 dimer interface [polypeptide binding]; other site 315750009246 conserved gate region; other site 315750009247 putative PBP binding loops; other site 315750009248 ABC-ATPase subunit interface; other site 315750009249 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315750009250 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 315750009251 substrate binding site [chemical binding]; other site 315750009252 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 315750009253 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750009254 inhibitor-cofactor binding pocket; inhibition site 315750009255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750009256 catalytic residue [active] 315750009257 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 315750009258 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 315750009259 putative trimer interface [polypeptide binding]; other site 315750009260 putative CoA binding site [chemical binding]; other site 315750009261 Bacterial sugar transferase; Region: Bac_transf; pfam02397 315750009262 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 315750009263 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 315750009264 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 315750009265 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315750009266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009267 active site 315750009268 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750009269 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 315750009270 putative ADP-binding pocket [chemical binding]; other site 315750009271 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750009272 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750009273 active site 315750009274 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 315750009275 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750009276 putative ADP-binding pocket [chemical binding]; other site 315750009277 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315750009278 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 315750009279 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315750009280 NAD(P) binding site [chemical binding]; other site 315750009281 homodimer interface [polypeptide binding]; other site 315750009282 substrate binding site [chemical binding]; other site 315750009283 active site 315750009284 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315750009285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315750009286 Magnesium ion binding site [ion binding]; other site 315750009287 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 315750009288 Chain length determinant protein; Region: Wzz; cl15801 315750009289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750009290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750009291 non-specific DNA binding site [nucleotide binding]; other site 315750009292 salt bridge; other site 315750009293 sequence-specific DNA binding site [nucleotide binding]; other site 315750009294 Anti-repressor SinI; Region: SinI; pfam08671 315750009295 Phage lysis protein, holin; Region: Phage_holin; pfam04688 315750009296 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750009297 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750009298 putative ligand binding residues [chemical binding]; other site 315750009299 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315750009300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750009301 ABC-ATPase subunit interface; other site 315750009302 dimer interface [polypeptide binding]; other site 315750009303 putative PBP binding regions; other site 315750009304 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315750009305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750009306 ABC-ATPase subunit interface; other site 315750009307 dimer interface [polypeptide binding]; other site 315750009308 putative PBP binding regions; other site 315750009309 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750009310 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750009311 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750009312 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750009313 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750009314 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750009315 ABC transporter; Region: ABC_tran_2; pfam12848 315750009316 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315750009317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315750009318 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 315750009319 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750009320 Walker A/P-loop; other site 315750009321 ATP binding site [chemical binding]; other site 315750009322 Q-loop/lid; other site 315750009323 ABC transporter signature motif; other site 315750009324 Walker B; other site 315750009325 D-loop; other site 315750009326 H-loop/switch region; other site 315750009327 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315750009328 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 315750009329 Walker A/P-loop; other site 315750009330 ATP binding site [chemical binding]; other site 315750009331 Q-loop/lid; other site 315750009332 ABC transporter signature motif; other site 315750009333 Walker B; other site 315750009334 D-loop; other site 315750009335 H-loop/switch region; other site 315750009336 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750009337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009338 dimer interface [polypeptide binding]; other site 315750009339 conserved gate region; other site 315750009340 putative PBP binding loops; other site 315750009341 ABC-ATPase subunit interface; other site 315750009342 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 315750009343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009344 dimer interface [polypeptide binding]; other site 315750009345 conserved gate region; other site 315750009346 putative PBP binding loops; other site 315750009347 ABC-ATPase subunit interface; other site 315750009348 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315750009349 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 315750009350 substrate binding site [chemical binding]; other site 315750009351 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315750009352 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315750009353 active site 315750009354 TDP-binding site; other site 315750009355 acceptor substrate-binding pocket; other site 315750009356 homodimer interface [polypeptide binding]; other site 315750009357 TM2 domain; Region: TM2; pfam05154 315750009358 Clp protease; Region: CLP_protease; pfam00574 315750009359 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 315750009360 oligomer interface [polypeptide binding]; other site 315750009361 active site residues [active] 315750009362 TIGR00730 family protein; Region: TIGR00730 315750009363 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 315750009364 metal binding site [ion binding]; metal-binding site 315750009365 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315750009366 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 315750009367 Sulfate transporter family; Region: Sulfate_transp; pfam00916 315750009368 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315750009369 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315750009370 active site clefts [active] 315750009371 zinc binding site [ion binding]; other site 315750009372 dimer interface [polypeptide binding]; other site 315750009373 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 315750009374 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 315750009375 dimerization interface [polypeptide binding]; other site 315750009376 ligand binding site [chemical binding]; other site 315750009377 NADP binding site [chemical binding]; other site 315750009378 catalytic site [active] 315750009379 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 315750009380 active site 315750009381 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 315750009382 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315750009383 dimerization domain swap beta strand [polypeptide binding]; other site 315750009384 regulatory protein interface [polypeptide binding]; other site 315750009385 active site 315750009386 regulatory phosphorylation site [posttranslational modification]; other site 315750009387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 315750009388 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 315750009389 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 315750009390 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 315750009391 phosphate binding site [ion binding]; other site 315750009392 putative substrate binding pocket [chemical binding]; other site 315750009393 dimer interface [polypeptide binding]; other site 315750009394 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 315750009395 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315750009396 putative active site [active] 315750009397 nucleotide binding site [chemical binding]; other site 315750009398 nudix motif; other site 315750009399 putative metal binding site [ion binding]; other site 315750009400 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 315750009401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315750009402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750009403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315750009404 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750009405 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750009406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750009407 binding surface 315750009408 TPR motif; other site 315750009409 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750009410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750009411 TPR motif; other site 315750009412 binding surface 315750009413 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 315750009414 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 315750009415 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 315750009416 metal binding site [ion binding]; metal-binding site 315750009417 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 315750009418 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 315750009419 substrate binding site [chemical binding]; other site 315750009420 glutamase interaction surface [polypeptide binding]; other site 315750009421 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 315750009422 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 315750009423 catalytic residues [active] 315750009424 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 315750009425 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 315750009426 putative active site [active] 315750009427 oxyanion strand; other site 315750009428 catalytic triad [active] 315750009429 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 315750009430 putative active site pocket [active] 315750009431 4-fold oligomerization interface [polypeptide binding]; other site 315750009432 metal binding residues [ion binding]; metal-binding site 315750009433 3-fold/trimer interface [polypeptide binding]; other site 315750009434 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 315750009435 histidinol dehydrogenase; Region: hisD; TIGR00069 315750009436 NAD binding site [chemical binding]; other site 315750009437 dimerization interface [polypeptide binding]; other site 315750009438 product binding site; other site 315750009439 substrate binding site [chemical binding]; other site 315750009440 zinc binding site [ion binding]; other site 315750009441 catalytic residues [active] 315750009442 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 315750009443 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 315750009444 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 315750009445 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 315750009446 dimer interface [polypeptide binding]; other site 315750009447 motif 1; other site 315750009448 active site 315750009449 motif 2; other site 315750009450 motif 3; other site 315750009451 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 315750009452 putative active site [active] 315750009453 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 315750009454 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315750009455 catalytic residues [active] 315750009456 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315750009457 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315750009458 NAD binding site [chemical binding]; other site 315750009459 substrate binding site [chemical binding]; other site 315750009460 putative active site [active] 315750009461 Predicted transcriptional regulator [Transcription]; Region: COG1959 315750009462 Transcriptional regulator; Region: Rrf2; pfam02082 315750009463 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 315750009464 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 315750009465 trimer interface [polypeptide binding]; other site 315750009466 active site 315750009467 substrate binding site [chemical binding]; other site 315750009468 CoA binding site [chemical binding]; other site 315750009469 pyrophosphatase PpaX; Provisional; Region: PRK13288 315750009470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009471 active site 315750009472 motif I; other site 315750009473 motif II; other site 315750009474 Nucleoside recognition; Region: Gate; pfam07670 315750009475 Nucleoside recognition; Region: Gate; pfam07670 315750009476 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 315750009477 HPr kinase/phosphorylase; Provisional; Region: PRK05428 315750009478 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 315750009479 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 315750009480 Hpr binding site; other site 315750009481 active site 315750009482 homohexamer subunit interaction site [polypeptide binding]; other site 315750009483 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 315750009484 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 315750009485 active site 315750009486 dimer interface [polypeptide binding]; other site 315750009487 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 315750009488 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 315750009489 active site 315750009490 trimer interface [polypeptide binding]; other site 315750009491 allosteric site; other site 315750009492 active site lid [active] 315750009493 hexamer (dimer of trimers) interface [polypeptide binding]; other site 315750009494 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750009495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750009496 DNA-binding site [nucleotide binding]; DNA binding site 315750009497 UTRA domain; Region: UTRA; pfam07702 315750009498 Lamin Tail Domain; Region: LTD; pfam00932 315750009499 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 315750009500 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 315750009501 putative active site [active] 315750009502 putative metal binding site [ion binding]; other site 315750009503 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315750009504 Predicted membrane protein [Function unknown]; Region: COG1950 315750009505 PspC domain; Region: PspC; pfam04024 315750009506 Uncharacterized conserved protein [Function unknown]; Region: COG3595 315750009507 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315750009508 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315750009509 Tic20-like protein; Region: Tic20; pfam09685 315750009510 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 315750009511 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 315750009512 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 315750009513 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 315750009514 excinuclease ABC subunit B; Provisional; Region: PRK05298 315750009515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750009516 ATP binding site [chemical binding]; other site 315750009517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009518 nucleotide binding region [chemical binding]; other site 315750009519 ATP-binding site [chemical binding]; other site 315750009520 Ultra-violet resistance protein B; Region: UvrB; pfam12344 315750009521 UvrB/uvrC motif; Region: UVR; pfam02151 315750009522 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 315750009523 phosphoenolpyruvate synthase; Validated; Region: PRK06241 315750009524 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 315750009525 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 315750009526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750009527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750009528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750009530 putative substrate translocation pore; other site 315750009531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009532 Uncharacterized conserved protein [Function unknown]; Region: COG3391 315750009533 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315750009534 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315750009535 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750009536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009537 active site 315750009538 phosphorylation site [posttranslational modification] 315750009539 intermolecular recognition site; other site 315750009540 dimerization interface [polypeptide binding]; other site 315750009541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750009542 DNA binding site [nucleotide binding] 315750009543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750009544 dimerization interface [polypeptide binding]; other site 315750009545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750009546 dimer interface [polypeptide binding]; other site 315750009547 phosphorylation site [posttranslational modification] 315750009548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009549 ATP binding site [chemical binding]; other site 315750009550 Mg2+ binding site [ion binding]; other site 315750009551 G-X-G motif; other site 315750009552 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 315750009553 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 315750009554 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 315750009555 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 315750009556 Ligand binding site; other site 315750009557 Putative Catalytic site; other site 315750009558 DXD motif; other site 315750009559 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 315750009560 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750009561 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 315750009562 dimer interface [polypeptide binding]; other site 315750009563 FMN binding site [chemical binding]; other site 315750009564 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750009565 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315750009566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750009567 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315750009568 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 315750009569 C-terminal peptidase (prc); Region: prc; TIGR00225 315750009570 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 315750009571 protein binding site [polypeptide binding]; other site 315750009572 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 315750009573 Catalytic dyad [active] 315750009574 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315750009575 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315750009576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315750009577 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750009578 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315750009579 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 315750009580 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 315750009581 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 315750009582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750009583 Walker A/P-loop; other site 315750009584 ATP binding site [chemical binding]; other site 315750009585 Q-loop/lid; other site 315750009586 ABC transporter signature motif; other site 315750009587 Walker B; other site 315750009588 D-loop; other site 315750009589 H-loop/switch region; other site 315750009590 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315750009591 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 315750009592 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750009593 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750009594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750009595 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315750009596 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750009597 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 315750009598 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 315750009599 active site 315750009600 Zn binding site [ion binding]; other site 315750009601 peptide chain release factor 2; Provisional; Region: PRK06746 315750009602 This domain is found in peptide chain release factors; Region: PCRF; smart00937 315750009603 RF-1 domain; Region: RF-1; pfam00472 315750009604 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 315750009605 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 315750009606 nucleotide binding region [chemical binding]; other site 315750009607 helicase superfamily c-terminal domain; Region: HELICc; smart00490 315750009608 ATP-binding site [chemical binding]; other site 315750009609 SEC-C motif; Region: SEC-C; pfam02810 315750009610 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 315750009611 30S subunit binding site; other site 315750009612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750009613 dimerization interface [polypeptide binding]; other site 315750009614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750009615 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750009616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750009617 dimer interface [polypeptide binding]; other site 315750009618 putative CheW interface [polypeptide binding]; other site 315750009619 flagellar protein FliS; Validated; Region: fliS; PRK05685 315750009620 flagellar capping protein; Validated; Region: fliD; PRK07737 315750009621 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 315750009622 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 315750009623 flagellar protein FlaG; Provisional; Region: PRK07738 315750009624 carbon storage regulator; Provisional; Region: PRK01712 315750009625 flagellar assembly protein FliW; Provisional; Region: PRK13285 315750009626 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 315750009627 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750009628 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750009629 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 315750009630 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315750009631 FlgN protein; Region: FlgN; pfam05130 315750009632 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 315750009633 flagellar operon protein TIGR03826; Region: YvyF 315750009634 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 315750009635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750009636 Late competence development protein ComFB; Region: ComFB; pfam10719 315750009637 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 315750009638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750009639 ATP binding site [chemical binding]; other site 315750009640 putative Mg++ binding site [ion binding]; other site 315750009641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009642 nucleotide binding region [chemical binding]; other site 315750009643 ATP-binding site [chemical binding]; other site 315750009644 EDD domain protein, DegV family; Region: DegV; TIGR00762 315750009645 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315750009646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750009647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009648 active site 315750009649 phosphorylation site [posttranslational modification] 315750009650 intermolecular recognition site; other site 315750009651 dimerization interface [polypeptide binding]; other site 315750009652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750009653 DNA binding residues [nucleotide binding] 315750009654 dimerization interface [polypeptide binding]; other site 315750009655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750009656 Histidine kinase; Region: HisKA_3; pfam07730 315750009657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009658 ATP binding site [chemical binding]; other site 315750009659 Mg2+ binding site [ion binding]; other site 315750009660 G-X-G motif; other site 315750009661 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 315750009662 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 315750009663 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 315750009664 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315750009665 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 315750009666 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 315750009667 Mg++ binding site [ion binding]; other site 315750009668 putative catalytic motif [active] 315750009669 substrate binding site [chemical binding]; other site 315750009670 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 315750009671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750009672 putative homodimer interface [polypeptide binding]; other site 315750009673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750009674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009675 active site 315750009676 O-Antigen ligase; Region: Wzy_C; pfam04932 315750009677 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315750009678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009679 NAD(P) binding site [chemical binding]; other site 315750009680 active site 315750009681 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315750009682 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 315750009683 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315750009684 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315750009685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750009686 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 315750009687 colanic acid exporter; Provisional; Region: PRK10459 315750009688 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 315750009689 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 315750009690 Bacterial sugar transferase; Region: Bac_transf; pfam02397 315750009691 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 315750009692 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009693 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009694 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009695 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315750009696 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750009697 active site 315750009698 metal binding site [ion binding]; metal-binding site 315750009699 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009700 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 315750009701 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009702 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009703 Stage II sporulation protein; Region: SpoIID; pfam08486 315750009704 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 315750009705 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 315750009706 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 315750009707 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 315750009708 active site 315750009709 homodimer interface [polypeptide binding]; other site 315750009710 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 315750009711 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 315750009712 active site 315750009713 tetramer interface; other site 315750009714 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 315750009715 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 315750009716 Walker A/P-loop; other site 315750009717 ATP binding site [chemical binding]; other site 315750009718 Q-loop/lid; other site 315750009719 ABC transporter signature motif; other site 315750009720 Walker B; other site 315750009721 D-loop; other site 315750009722 H-loop/switch region; other site 315750009723 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 315750009724 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 315750009725 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750009726 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009727 active site 315750009728 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 315750009729 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750009730 inhibitor-cofactor binding pocket; inhibition site 315750009731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750009732 catalytic residue [active] 315750009733 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 315750009734 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 315750009735 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009736 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 315750009737 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 315750009738 NAD binding site [chemical binding]; other site 315750009739 substrate binding site [chemical binding]; other site 315750009740 homodimer interface [polypeptide binding]; other site 315750009741 active site 315750009742 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 315750009743 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 315750009744 substrate binding site; other site 315750009745 tetramer interface; other site 315750009746 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 315750009747 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009748 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 315750009749 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 315750009750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750009751 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 315750009752 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 315750009753 active site 315750009754 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 315750009755 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 315750009756 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 315750009757 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 315750009758 Bacterial SH3 domain; Region: SH3_3; pfam08239 315750009759 Lysozyme subfamily 2; Region: LYZ2; smart00047 315750009760 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 315750009761 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750009763 SH3-like domain; Region: SH3_8; pfam13457 315750009764 SH3-like domain; Region: SH3_8; pfam13457 315750009765 SH3-like domain; Region: SH3_8; pfam13457 315750009766 SH3-like domain; Region: SH3_8; pfam13457 315750009767 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315750009768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750009769 putative ADP-binding pocket [chemical binding]; other site 315750009770 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 315750009771 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 315750009772 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750009773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009774 dimer interface [polypeptide binding]; other site 315750009775 conserved gate region; other site 315750009776 putative PBP binding loops; other site 315750009777 ABC-ATPase subunit interface; other site 315750009778 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 315750009779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009780 dimer interface [polypeptide binding]; other site 315750009781 ABC-ATPase subunit interface; other site 315750009782 putative PBP binding loops; other site 315750009783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315750009784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 315750009785 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 315750009786 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 315750009787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009788 active site 315750009789 phosphorylation site [posttranslational modification] 315750009790 intermolecular recognition site; other site 315750009791 dimerization interface [polypeptide binding]; other site 315750009792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750009793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750009794 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 315750009795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750009796 dimerization interface [polypeptide binding]; other site 315750009797 Histidine kinase; Region: His_kinase; pfam06580 315750009798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009799 ATP binding site [chemical binding]; other site 315750009800 Mg2+ binding site [ion binding]; other site 315750009801 G-X-G motif; other site 315750009802 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 315750009803 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315750009804 ligand binding site [chemical binding]; other site 315750009805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750009806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750009807 Coenzyme A binding pocket [chemical binding]; other site 315750009808 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 315750009809 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 315750009810 active site 315750009811 intersubunit interface [polypeptide binding]; other site 315750009812 catalytic residue [active] 315750009813 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315750009814 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 315750009815 substrate binding site [chemical binding]; other site 315750009816 ATP binding site [chemical binding]; other site 315750009817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750009818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750009819 DNA binding site [nucleotide binding] 315750009820 domain linker motif; other site 315750009821 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 315750009822 putative dimerization interface [polypeptide binding]; other site 315750009823 putative ligand binding site [chemical binding]; other site 315750009824 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 315750009825 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 315750009826 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 315750009827 NADP binding site [chemical binding]; other site 315750009828 homodimer interface [polypeptide binding]; other site 315750009829 active site 315750009830 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750009831 Spore germination protein; Region: Spore_permease; cl17796 315750009832 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315750009833 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315750009834 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315750009835 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 315750009836 Probable Catalytic site; other site 315750009837 metal-binding site 315750009838 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315750009839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750009840 S-adenosylmethionine binding site [chemical binding]; other site 315750009841 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 315750009842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009843 putative substrate translocation pore; other site 315750009844 Transcriptional regulator [Transcription]; Region: LytR; COG1316 315750009845 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750009846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009847 active site 315750009848 motif I; other site 315750009849 motif II; other site 315750009850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009851 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750009852 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750009853 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750009854 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750009855 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315750009856 NlpC/P60 family; Region: NLPC_P60; pfam00877 315750009857 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 315750009858 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 315750009859 putative active site [active] 315750009860 putative metal binding site [ion binding]; other site 315750009861 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 315750009862 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 315750009863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750009864 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750009865 Spore germination protein; Region: Spore_permease; cl17796 315750009866 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315750009867 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315750009868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750009869 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750009870 DNA binding site [nucleotide binding] 315750009871 domain linker motif; other site 315750009872 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 315750009873 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315750009874 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 315750009875 substrate binding site [chemical binding]; other site 315750009876 dimer interface [polypeptide binding]; other site 315750009877 ATP binding site [chemical binding]; other site 315750009878 D-ribose pyranase; Provisional; Region: PRK11797 315750009879 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315750009880 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315750009881 Walker A/P-loop; other site 315750009882 ATP binding site [chemical binding]; other site 315750009883 Q-loop/lid; other site 315750009884 ABC transporter signature motif; other site 315750009885 Walker B; other site 315750009886 D-loop; other site 315750009887 H-loop/switch region; other site 315750009888 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315750009889 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315750009890 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315750009891 TM-ABC transporter signature motif; other site 315750009892 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 315750009893 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315750009894 ligand binding site [chemical binding]; other site 315750009895 dimerization interface [polypeptide binding]; other site 315750009896 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 315750009897 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 315750009898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750009899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750009900 dimerization interface [polypeptide binding]; other site 315750009901 acetolactate synthase; Reviewed; Region: PRK08617 315750009902 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315750009903 PYR/PP interface [polypeptide binding]; other site 315750009904 dimer interface [polypeptide binding]; other site 315750009905 TPP binding site [chemical binding]; other site 315750009906 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315750009907 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 315750009908 TPP-binding site [chemical binding]; other site 315750009909 dimer interface [polypeptide binding]; other site 315750009910 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 315750009911 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315750009912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750009913 putative DNA binding site [nucleotide binding]; other site 315750009914 putative Zn2+ binding site [ion binding]; other site 315750009915 AsnC family; Region: AsnC_trans_reg; pfam01037 315750009916 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 315750009917 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 315750009918 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315750009919 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 315750009920 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315750009921 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315750009922 SWIM zinc finger; Region: SWIM; pfam04434 315750009923 SNF2 Helicase protein; Region: DUF3670; pfam12419 315750009924 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 315750009925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750009926 ATP binding site [chemical binding]; other site 315750009927 putative Mg++ binding site [ion binding]; other site 315750009928 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 315750009929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009930 nucleotide binding region [chemical binding]; other site 315750009931 ATP-binding site [chemical binding]; other site 315750009932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750009933 PAS domain; Region: PAS_9; pfam13426 315750009934 putative active site [active] 315750009935 heme pocket [chemical binding]; other site 315750009936 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750009937 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750009938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009939 motif II; other site 315750009940 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 315750009941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009942 YwpF-like protein; Region: YwpF; pfam14183 315750009943 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 315750009944 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 315750009945 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 315750009946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750009947 binding surface 315750009948 TPR motif; other site 315750009949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750009950 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 315750009951 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 315750009952 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315750009953 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 315750009954 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 315750009955 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315750009956 rod shape-determining protein Mbl; Provisional; Region: PRK13928 315750009957 MreB and similar proteins; Region: MreB_like; cd10225 315750009958 nucleotide binding site [chemical binding]; other site 315750009959 Mg binding site [ion binding]; other site 315750009960 putative protofilament interaction site [polypeptide binding]; other site 315750009961 RodZ interaction site [polypeptide binding]; other site 315750009962 Stage III sporulation protein D; Region: SpoIIID; pfam12116 315750009963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750009964 MarR family; Region: MarR; pfam01047 315750009965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750009967 putative substrate translocation pore; other site 315750009968 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315750009969 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315750009970 active site 315750009971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009972 D-galactonate transporter; Region: 2A0114; TIGR00893 315750009973 putative substrate translocation pore; other site 315750009974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750009976 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750009977 substrate binding pocket [chemical binding]; other site 315750009978 membrane-bound complex binding site; other site 315750009979 hinge residues; other site 315750009980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009981 dimer interface [polypeptide binding]; other site 315750009982 conserved gate region; other site 315750009983 putative PBP binding loops; other site 315750009984 ABC-ATPase subunit interface; other site 315750009985 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750009986 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750009987 Walker A/P-loop; other site 315750009988 ATP binding site [chemical binding]; other site 315750009989 Q-loop/lid; other site 315750009990 ABC transporter signature motif; other site 315750009991 Walker B; other site 315750009992 D-loop; other site 315750009993 H-loop/switch region; other site 315750009994 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 315750009995 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 315750009996 Nitrogen regulatory protein P-II; Region: P-II; smart00938 315750009997 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315750009998 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750009999 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315750010000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750010001 Coenzyme A binding pocket [chemical binding]; other site 315750010002 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315750010003 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315750010004 Methylamine utilisation protein MauE; Region: MauE; pfam07291 315750010005 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750010006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750010007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750010008 Walker A/P-loop; other site 315750010009 ATP binding site [chemical binding]; other site 315750010010 Q-loop/lid; other site 315750010011 ABC transporter signature motif; other site 315750010012 Walker B; other site 315750010013 D-loop; other site 315750010014 H-loop/switch region; other site 315750010015 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 315750010016 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 315750010017 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 315750010018 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 315750010019 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 315750010020 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 315750010021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750010022 FeS/SAM binding site; other site 315750010023 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 315750010024 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 315750010025 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 315750010026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010027 putative substrate translocation pore; other site 315750010028 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 315750010029 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315750010030 molybdopterin cofactor binding site; other site 315750010031 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 315750010032 molybdopterin cofactor binding site; other site 315750010033 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750010034 metal ion-dependent adhesion site (MIDAS); other site 315750010035 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750010036 metal ion-dependent adhesion site (MIDAS); other site 315750010037 stage II sporulation protein D; Region: spore_II_D; TIGR02870 315750010038 Stage II sporulation protein; Region: SpoIID; pfam08486 315750010039 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315750010040 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315750010041 hinge; other site 315750010042 active site 315750010043 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 315750010044 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 315750010045 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 315750010046 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 315750010047 gamma subunit interface [polypeptide binding]; other site 315750010048 epsilon subunit interface [polypeptide binding]; other site 315750010049 LBP interface [polypeptide binding]; other site 315750010050 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 315750010051 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 315750010052 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 315750010053 alpha subunit interaction interface [polypeptide binding]; other site 315750010054 Walker A motif; other site 315750010055 ATP binding site [chemical binding]; other site 315750010056 Walker B motif; other site 315750010057 inhibitor binding site; inhibition site 315750010058 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315750010059 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 315750010060 core domain interface [polypeptide binding]; other site 315750010061 delta subunit interface [polypeptide binding]; other site 315750010062 epsilon subunit interface [polypeptide binding]; other site 315750010063 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 315750010064 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 315750010065 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 315750010066 beta subunit interaction interface [polypeptide binding]; other site 315750010067 Walker A motif; other site 315750010068 ATP binding site [chemical binding]; other site 315750010069 Walker B motif; other site 315750010070 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315750010071 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 315750010072 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 315750010073 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 315750010074 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 315750010075 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 315750010076 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 315750010077 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 315750010078 ATP synthase I chain; Region: ATP_synt_I; pfam03899 315750010079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750010080 active site 315750010081 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 315750010082 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 315750010083 dimer interface [polypeptide binding]; other site 315750010084 active site 315750010085 glycine-pyridoxal phosphate binding site [chemical binding]; other site 315750010086 folate binding site [chemical binding]; other site 315750010087 hypothetical protein; Provisional; Region: PRK13690 315750010088 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 315750010089 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315750010090 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315750010091 active site 315750010092 Predicted membrane protein [Function unknown]; Region: COG1971 315750010093 Domain of unknown function DUF; Region: DUF204; pfam02659 315750010094 Domain of unknown function DUF; Region: DUF204; pfam02659 315750010095 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 315750010096 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 315750010097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315750010098 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 315750010099 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 315750010100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750010101 S-adenosylmethionine binding site [chemical binding]; other site 315750010102 peptide chain release factor 1; Validated; Region: prfA; PRK00591 315750010103 This domain is found in peptide chain release factors; Region: PCRF; smart00937 315750010104 RF-1 domain; Region: RF-1; pfam00472 315750010105 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 315750010106 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 315750010107 DNA binding residues [nucleotide binding] 315750010108 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 315750010109 malate dehydrogenase; Provisional; Region: PRK13529 315750010110 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315750010111 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 315750010112 NAD(P) binding site [chemical binding]; other site 315750010113 thymidine kinase; Provisional; Region: PRK04296 315750010114 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 315750010115 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 315750010116 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 315750010117 putative active site [active] 315750010118 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315750010119 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315750010120 hinge; other site 315750010121 active site 315750010122 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 315750010123 active site 315750010124 intersubunit interactions; other site 315750010125 catalytic residue [active] 315750010126 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 315750010127 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 315750010128 intersubunit interface [polypeptide binding]; other site 315750010129 active site 315750010130 zinc binding site [ion binding]; other site 315750010131 Na+ binding site [ion binding]; other site 315750010132 Response regulator receiver domain; Region: Response_reg; pfam00072 315750010133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750010134 active site 315750010135 phosphorylation site [posttranslational modification] 315750010136 intermolecular recognition site; other site 315750010137 dimerization interface [polypeptide binding]; other site 315750010138 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 315750010139 CTP synthetase; Validated; Region: pyrG; PRK05380 315750010140 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 315750010141 Catalytic site [active] 315750010142 active site 315750010143 UTP binding site [chemical binding]; other site 315750010144 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 315750010145 active site 315750010146 putative oxyanion hole; other site 315750010147 catalytic triad [active] 315750010148 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 315750010149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750010150 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 315750010151 Walker A/P-loop; other site 315750010152 ATP binding site [chemical binding]; other site 315750010153 Q-loop/lid; other site 315750010154 ABC transporter signature motif; other site 315750010155 Walker B; other site 315750010156 D-loop; other site 315750010157 H-loop/switch region; other site 315750010158 Integral membrane protein DUF95; Region: DUF95; pfam01944 315750010159 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750010160 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315750010161 FAD binding site [chemical binding]; other site 315750010162 homotetramer interface [polypeptide binding]; other site 315750010163 substrate binding pocket [chemical binding]; other site 315750010164 catalytic base [active] 315750010165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750010166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315750010167 active site 315750010168 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 315750010169 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 315750010170 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750010171 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 315750010172 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315750010173 dimer interface [polypeptide binding]; other site 315750010174 active site 315750010175 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 315750010176 Protein of unknown function (DUF998); Region: DUF998; pfam06197 315750010177 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315750010178 4Fe-4S binding domain; Region: Fer4; cl02805 315750010179 Cysteine-rich domain; Region: CCG; pfam02754 315750010180 Cysteine-rich domain; Region: CCG; pfam02754 315750010181 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315750010182 PLD-like domain; Region: PLDc_2; pfam13091 315750010183 putative active site [active] 315750010184 catalytic site [active] 315750010185 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315750010186 PLD-like domain; Region: PLDc_2; pfam13091 315750010187 putative active site [active] 315750010188 catalytic site [active] 315750010189 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 315750010190 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315750010191 putative dimer interface [polypeptide binding]; other site 315750010192 catalytic triad [active] 315750010193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750010194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750010195 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 315750010196 Walker A/P-loop; other site 315750010197 ATP binding site [chemical binding]; other site 315750010198 Q-loop/lid; other site 315750010199 ABC transporter signature motif; other site 315750010200 Walker B; other site 315750010201 D-loop; other site 315750010202 H-loop/switch region; other site 315750010203 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 315750010204 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 315750010205 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315750010206 putative active site [active] 315750010207 catalytic site [active] 315750010208 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315750010209 putative active site [active] 315750010210 catalytic site [active] 315750010211 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315750010212 putative dimer interface [polypeptide binding]; other site 315750010213 catalytic triad [active] 315750010214 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 315750010215 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 315750010216 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 315750010217 active site 315750010218 HIGH motif; other site 315750010219 KMSK motif region; other site 315750010220 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 315750010221 tRNA binding surface [nucleotide binding]; other site 315750010222 anticodon binding site; other site 315750010223 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 315750010224 agmatinase; Region: agmatinase; TIGR01230 315750010225 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 315750010226 putative active site [active] 315750010227 Mn binding site [ion binding]; other site 315750010228 spermidine synthase; Provisional; Region: PRK00811 315750010229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750010230 Transglycosylase; Region: Transgly; pfam00912 315750010231 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750010232 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 315750010233 YwhD family; Region: YwhD; pfam08741 315750010234 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 315750010235 Peptidase family M50; Region: Peptidase_M50; pfam02163 315750010236 active site 315750010237 putative substrate binding region [chemical binding]; other site 315750010238 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 315750010239 active site 1 [active] 315750010240 dimer interface [polypeptide binding]; other site 315750010241 hexamer interface [polypeptide binding]; other site 315750010242 active site 2 [active] 315750010243 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 315750010244 Uncharacterized conserved protein [Function unknown]; Region: COG3465 315750010245 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 315750010246 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750010247 Zn2+ binding site [ion binding]; other site 315750010248 Mg2+ binding site [ion binding]; other site 315750010249 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 315750010250 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315750010251 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315750010252 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 315750010253 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315750010254 DXD motif; other site 315750010255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750010256 PilZ domain; Region: PilZ; pfam07238 315750010257 PilZ domain; Region: PilZ; pfam07238 315750010258 TPR repeat; Region: TPR_11; pfam13414 315750010259 Tetratrico peptide repeat; Region: TPR_5; pfam12688 315750010260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750010261 binding surface 315750010262 TPR motif; other site 315750010263 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315750010264 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 315750010265 LXG domain of WXG superfamily; Region: LXG; pfam04740 315750010266 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750010267 Cytotoxic; Region: Cytotoxic; pfam09000 315750010268 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 315750010269 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315750010270 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 315750010271 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 315750010272 hypothetical protein; Validated; Region: PRK06201 315750010273 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 315750010274 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750010275 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750010276 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750010277 putative active site [active] 315750010278 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 315750010279 putative heme peroxidase; Provisional; Region: PRK12276 315750010280 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750010281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010282 putative substrate translocation pore; other site 315750010283 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315750010284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750010285 putative DNA binding site [nucleotide binding]; other site 315750010286 putative Zn2+ binding site [ion binding]; other site 315750010287 AsnC family; Region: AsnC_trans_reg; pfam01037 315750010288 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750010289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010290 putative substrate translocation pore; other site 315750010291 Prephenate dehydratase; Region: PDT; pfam00800 315750010292 Cupin domain; Region: Cupin_2; cl17218 315750010293 Cupin domain; Region: Cupin_2; pfam07883 315750010294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750010295 classical (c) SDRs; Region: SDR_c; cd05233 315750010296 NAD(P) binding site [chemical binding]; other site 315750010297 active site 315750010298 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 315750010299 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 315750010300 transaminase; Reviewed; Region: PRK08068 315750010301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750010302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750010303 homodimer interface [polypeptide binding]; other site 315750010304 catalytic residue [active] 315750010305 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750010306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750010307 NAD(P) binding site [chemical binding]; other site 315750010308 active site 315750010309 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 315750010310 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 315750010311 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 315750010312 NADP binding site [chemical binding]; other site 315750010313 active site 315750010314 putative substrate binding site [chemical binding]; other site 315750010315 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 315750010316 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 315750010317 NAD binding site [chemical binding]; other site 315750010318 substrate binding site [chemical binding]; other site 315750010319 homodimer interface [polypeptide binding]; other site 315750010320 active site 315750010321 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 315750010322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750010323 active site 315750010324 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 315750010325 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750010326 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 315750010327 ligand binding site; other site 315750010328 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 315750010329 NeuB family; Region: NeuB; pfam03102 315750010330 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 315750010331 NeuB binding interface [polypeptide binding]; other site 315750010332 putative substrate binding site [chemical binding]; other site 315750010333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750010334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750010335 Coenzyme A binding pocket [chemical binding]; other site 315750010336 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 315750010337 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750010338 inhibitor-cofactor binding pocket; inhibition site 315750010339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750010340 catalytic residue [active] 315750010341 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 315750010342 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750010343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750010344 active site 315750010345 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 315750010346 Cupin; Region: Cupin_1; smart00835 315750010347 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 315750010348 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 315750010349 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 315750010350 ligand binding site [chemical binding]; other site 315750010351 active site 315750010352 UGI interface [polypeptide binding]; other site 315750010353 catalytic site [active] 315750010354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750010355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750010356 active site 315750010357 Heat induced stress protein YflT; Region: YflT; pfam11181 315750010358 Heat induced stress protein YflT; Region: YflT; pfam11181 315750010359 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315750010360 dimer interface [polypeptide binding]; other site 315750010361 substrate binding site [chemical binding]; other site 315750010362 ATP binding site [chemical binding]; other site 315750010363 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 315750010364 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 315750010365 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 315750010366 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 315750010367 substrate binding [chemical binding]; other site 315750010368 active site 315750010369 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 315750010370 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 315750010371 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750010372 active site turn [active] 315750010373 phosphorylation site [posttranslational modification] 315750010374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750010375 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750010376 CAT RNA binding domain; Region: CAT_RBD; smart01061 315750010377 PRD domain; Region: PRD; pfam00874 315750010378 PRD domain; Region: PRD; pfam00874 315750010379 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315750010380 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 315750010381 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315750010382 putative active site [active] 315750010383 catalytic triad [active] 315750010384 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 315750010385 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315750010386 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 315750010387 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 315750010388 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750010389 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 315750010390 dimer interface [polypeptide binding]; other site 315750010391 FMN binding site [chemical binding]; other site 315750010392 NADPH bind site [chemical binding]; other site 315750010393 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 315750010394 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 315750010395 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315750010396 Subunit I/III interface [polypeptide binding]; other site 315750010397 Subunit III/IV interface [polypeptide binding]; other site 315750010398 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315750010399 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315750010400 D-pathway; other site 315750010401 Putative ubiquinol binding site [chemical binding]; other site 315750010402 Low-spin heme (heme b) binding site [chemical binding]; other site 315750010403 Putative water exit pathway; other site 315750010404 Binuclear center (heme o3/CuB) [ion binding]; other site 315750010405 K-pathway; other site 315750010406 Putative proton exit pathway; other site 315750010407 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 315750010408 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 315750010409 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 315750010410 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315750010411 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315750010412 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 315750010413 active site 315750010414 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 315750010415 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 315750010416 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 315750010417 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 315750010418 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 315750010419 NAD binding site [chemical binding]; other site 315750010420 homodimer interface [polypeptide binding]; other site 315750010421 active site 315750010422 substrate binding site [chemical binding]; other site 315750010423 galactokinase; Provisional; Region: PRK05322 315750010424 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 315750010425 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315750010426 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315750010427 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 315750010428 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750010429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750010430 Predicted membrane protein [Function unknown]; Region: COG2246 315750010431 GtrA-like protein; Region: GtrA; pfam04138 315750010432 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315750010433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750010434 S-adenosylmethionine binding site [chemical binding]; other site 315750010435 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 315750010436 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750010437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750010438 methionine aminopeptidase 2; Provisional; Region: PTZ00053 315750010439 Protein of unknown function, DUF485; Region: DUF485; cl01231 315750010440 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315750010441 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 315750010442 Na binding site [ion binding]; other site 315750010443 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 315750010444 SnoaL-like domain; Region: SnoaL_2; pfam12680 315750010445 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315750010446 thiamine phosphate binding site [chemical binding]; other site 315750010447 active site 315750010448 pyrophosphate binding site [ion binding]; other site 315750010449 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 315750010450 substrate binding site [chemical binding]; other site 315750010451 multimerization interface [polypeptide binding]; other site 315750010452 ATP binding site [chemical binding]; other site 315750010453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750010454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750010455 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 315750010456 putative dimerization interface [polypeptide binding]; other site 315750010457 holin-like protein; Validated; Region: PRK01658 315750010458 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 315750010459 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 315750010460 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 315750010461 putative RNA binding site [nucleotide binding]; other site 315750010462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750010463 S-adenosylmethionine binding site [chemical binding]; other site 315750010464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750010465 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315750010466 active site 315750010467 metal binding site [ion binding]; metal-binding site 315750010468 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750010469 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315750010470 Walker A/P-loop; other site 315750010471 ATP binding site [chemical binding]; other site 315750010472 Q-loop/lid; other site 315750010473 ABC transporter signature motif; other site 315750010474 Walker B; other site 315750010475 D-loop; other site 315750010476 H-loop/switch region; other site 315750010477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750010478 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315750010479 synthetase active site [active] 315750010480 NTP binding site [chemical binding]; other site 315750010481 metal binding site [ion binding]; metal-binding site 315750010482 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315750010483 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315750010484 TM-ABC transporter signature motif; other site 315750010485 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315750010486 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315750010487 Walker A/P-loop; other site 315750010488 ATP binding site [chemical binding]; other site 315750010489 Q-loop/lid; other site 315750010490 ABC transporter signature motif; other site 315750010491 Walker B; other site 315750010492 D-loop; other site 315750010493 H-loop/switch region; other site 315750010494 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315750010495 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 315750010496 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315750010497 putative ligand binding site [chemical binding]; other site 315750010498 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 315750010499 Right handed beta helix region; Region: Beta_helix; pfam13229 315750010500 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 315750010501 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 315750010502 homodimer interface [polypeptide binding]; other site 315750010503 substrate-cofactor binding pocket; other site 315750010504 catalytic residue [active] 315750010505 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315750010506 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 315750010507 NAD binding site [chemical binding]; other site 315750010508 sugar binding site [chemical binding]; other site 315750010509 divalent metal binding site [ion binding]; other site 315750010510 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750010511 dimer interface [polypeptide binding]; other site 315750010512 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315750010513 methionine cluster; other site 315750010514 active site 315750010515 phosphorylation site [posttranslational modification] 315750010516 metal binding site [ion binding]; metal-binding site 315750010517 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315750010518 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 315750010519 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315750010520 active site 315750010521 P-loop; other site 315750010522 phosphorylation site [posttranslational modification] 315750010523 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750010524 HTH domain; Region: HTH_11; pfam08279 315750010525 Mga helix-turn-helix domain; Region: Mga; pfam05043 315750010526 PRD domain; Region: PRD; pfam00874 315750010527 PRD domain; Region: PRD; pfam00874 315750010528 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750010529 active site 315750010530 P-loop; other site 315750010531 phosphorylation site [posttranslational modification] 315750010532 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750010533 active site 315750010534 phosphorylation site [posttranslational modification] 315750010535 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 315750010536 active site 315750010537 putative catalytic site [active] 315750010538 glutamate dehydrogenase; Provisional; Region: PRK09414 315750010539 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315750010540 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 315750010541 NAD(P) binding site [chemical binding]; other site 315750010542 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 315750010543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750010544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750010545 DNA binding residues [nucleotide binding] 315750010546 Amb_all domain; Region: Amb_all; smart00656 315750010547 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 315750010548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750010549 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 315750010550 Walker A/P-loop; other site 315750010551 ATP binding site [chemical binding]; other site 315750010552 Q-loop/lid; other site 315750010553 ABC transporter signature motif; other site 315750010554 Walker B; other site 315750010555 D-loop; other site 315750010556 H-loop/switch region; other site 315750010557 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 315750010558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315750010559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750010560 Walker A/P-loop; other site 315750010561 ATP binding site [chemical binding]; other site 315750010562 Q-loop/lid; other site 315750010563 ABC transporter signature motif; other site 315750010564 Walker B; other site 315750010565 D-loop; other site 315750010566 H-loop/switch region; other site 315750010567 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 315750010568 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 315750010569 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 315750010570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750010571 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750010572 Walker A/P-loop; other site 315750010573 ATP binding site [chemical binding]; other site 315750010574 Q-loop/lid; other site 315750010575 ABC transporter signature motif; other site 315750010576 Walker B; other site 315750010577 D-loop; other site 315750010578 H-loop/switch region; other site 315750010579 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315750010580 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315750010581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750010582 ABC-ATPase subunit interface; other site 315750010583 dimer interface [polypeptide binding]; other site 315750010584 putative PBP binding regions; other site 315750010585 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750010586 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315750010587 intersubunit interface [polypeptide binding]; other site 315750010588 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 315750010589 active site 315750010590 catalytic site [active] 315750010591 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750010592 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750010593 Walker A/P-loop; other site 315750010594 ATP binding site [chemical binding]; other site 315750010595 Q-loop/lid; other site 315750010596 ABC transporter signature motif; other site 315750010597 Walker B; other site 315750010598 D-loop; other site 315750010599 H-loop/switch region; other site 315750010600 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315750010601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750010602 ABC-ATPase subunit interface; other site 315750010603 dimer interface [polypeptide binding]; other site 315750010604 putative PBP binding regions; other site 315750010605 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 315750010606 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315750010607 intersubunit interface [polypeptide binding]; other site 315750010608 Predicted transcriptional regulators [Transcription]; Region: COG1733 315750010609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750010610 dimerization interface [polypeptide binding]; other site 315750010611 putative DNA binding site [nucleotide binding]; other site 315750010612 putative Zn2+ binding site [ion binding]; other site 315750010613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 315750010614 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315750010615 putative metal binding site [ion binding]; other site 315750010616 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315750010617 active site 315750010618 metal binding site [ion binding]; metal-binding site 315750010619 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 315750010620 dimerization interface [polypeptide binding]; other site 315750010621 active site 315750010622 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 315750010623 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 315750010624 catalytic motif [active] 315750010625 Zn binding site [ion binding]; other site 315750010626 RibD C-terminal domain; Region: RibD_C; cl17279 315750010627 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315750010628 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 315750010629 putative active site [active] 315750010630 putative metal binding site [ion binding]; other site 315750010631 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315750010632 methionine cluster; other site 315750010633 active site 315750010634 phosphorylation site [posttranslational modification] 315750010635 metal binding site [ion binding]; metal-binding site 315750010636 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315750010637 active site 315750010638 P-loop; other site 315750010639 phosphorylation site [posttranslational modification] 315750010640 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 315750010641 beta-galactosidase; Region: BGL; TIGR03356 315750010642 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 315750010643 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315750010644 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750010645 HTH domain; Region: HTH_11; pfam08279 315750010646 Mga helix-turn-helix domain; Region: Mga; pfam05043 315750010647 PRD domain; Region: PRD; pfam00874 315750010648 PRD domain; Region: PRD; pfam00874 315750010649 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750010650 active site 315750010651 P-loop; other site 315750010652 phosphorylation site [posttranslational modification] 315750010653 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750010654 active site 315750010655 phosphorylation site [posttranslational modification] 315750010656 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 315750010657 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315750010658 aspartate ammonia-lyase; Provisional; Region: PRK13353 315750010659 Aspartase; Region: Aspartase; cd01357 315750010660 active sites [active] 315750010661 tetramer interface [polypeptide binding]; other site 315750010662 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 315750010663 active site 315750010664 homodimer interface [polypeptide binding]; other site 315750010665 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750010666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750010667 sequence-specific DNA binding site [nucleotide binding]; other site 315750010668 salt bridge; other site 315750010669 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315750010670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750010671 non-specific DNA binding site [nucleotide binding]; other site 315750010672 salt bridge; other site 315750010673 sequence-specific DNA binding site [nucleotide binding]; other site 315750010674 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315750010675 peptidase T; Region: peptidase-T; TIGR01882 315750010676 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 315750010677 metal binding site [ion binding]; metal-binding site 315750010678 dimer interface [polypeptide binding]; other site 315750010679 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 315750010680 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750010681 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750010682 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750010683 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750010684 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750010685 putative active site [active] 315750010686 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 315750010687 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315750010688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 315750010689 GntP family permease; Region: GntP_permease; pfam02447 315750010690 fructuronate transporter; Provisional; Region: PRK10034; cl15264 315750010691 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 315750010692 substrate binding site [chemical binding]; other site 315750010693 THF binding site; other site 315750010694 zinc-binding site [ion binding]; other site 315750010695 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750010696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750010697 Walker A/P-loop; other site 315750010698 ATP binding site [chemical binding]; other site 315750010699 Q-loop/lid; other site 315750010700 ABC transporter signature motif; other site 315750010701 Walker B; other site 315750010702 D-loop; other site 315750010703 H-loop/switch region; other site 315750010704 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 315750010705 beta-galactosidase; Region: BGL; TIGR03356 315750010706 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750010707 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750010708 active site turn [active] 315750010709 phosphorylation site [posttranslational modification] 315750010710 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750010711 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315750010712 HPr interaction site; other site 315750010713 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750010714 active site 315750010715 phosphorylation site [posttranslational modification] 315750010716 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750010717 CAT RNA binding domain; Region: CAT_RBD; smart01061 315750010718 PRD domain; Region: PRD; pfam00874 315750010719 PRD domain; Region: PRD; pfam00874 315750010720 Transposase domain (DUF772); Region: DUF772; pfam05598 315750010721 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750010722 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 315750010723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 315750010724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750010725 dimer interface [polypeptide binding]; other site 315750010726 putative CheW interface [polypeptide binding]; other site 315750010727 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 315750010728 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 315750010729 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315750010730 Walker A/P-loop; other site 315750010731 ATP binding site [chemical binding]; other site 315750010732 Q-loop/lid; other site 315750010733 ABC transporter signature motif; other site 315750010734 Walker B; other site 315750010735 D-loop; other site 315750010736 H-loop/switch region; other site 315750010737 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315750010738 Walker A/P-loop; other site 315750010739 ATP binding site [chemical binding]; other site 315750010740 Q-loop/lid; other site 315750010741 ABC transporter signature motif; other site 315750010742 Walker B; other site 315750010743 D-loop; other site 315750010744 H-loop/switch region; other site 315750010745 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 315750010746 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 315750010747 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 315750010748 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 315750010749 potential catalytic triad [active] 315750010750 conserved cys residue [active] 315750010751 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 315750010752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315750010753 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 315750010754 Uncharacterized conserved protein [Function unknown]; Region: COG1359 315750010755 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315750010756 dimer interface [polypeptide binding]; other site 315750010757 FMN binding site [chemical binding]; other site 315750010758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750010759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750010760 putative DNA binding site [nucleotide binding]; other site 315750010761 putative Zn2+ binding site [ion binding]; other site 315750010762 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 315750010763 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315750010764 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315750010765 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 315750010766 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315750010767 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315750010768 Nucleoside recognition; Region: Gate; pfam07670 315750010769 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315750010770 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 315750010771 intersubunit interface [polypeptide binding]; other site 315750010772 active site 315750010773 catalytic residue [active] 315750010774 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750010775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750010776 DNA binding residues [nucleotide binding] 315750010777 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750010778 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 315750010779 active site 315750010780 catalytic residues [active] 315750010781 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 315750010782 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 315750010783 catalytic triad [active] 315750010784 catalytic triad [active] 315750010785 oxyanion hole [active] 315750010786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750010788 putative substrate translocation pore; other site 315750010789 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 315750010790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750010791 S-adenosylmethionine binding site [chemical binding]; other site 315750010792 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750010793 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750010794 DNA binding residues [nucleotide binding] 315750010795 dimerization interface [polypeptide binding]; other site 315750010796 sugar phosphate phosphatase; Provisional; Region: PRK10513 315750010797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750010798 active site 315750010799 motif I; other site 315750010800 motif II; other site 315750010801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750010802 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750010803 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315750010804 DNA binding residues [nucleotide binding] 315750010805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315750010806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315750010807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750010808 PAS fold; Region: PAS_3; pfam08447 315750010809 putative active site [active] 315750010810 heme pocket [chemical binding]; other site 315750010811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750010812 PAS fold; Region: PAS_3; pfam08447 315750010813 putative active site [active] 315750010814 heme pocket [chemical binding]; other site 315750010815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750010816 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750010817 dimer interface [polypeptide binding]; other site 315750010818 putative CheW interface [polypeptide binding]; other site 315750010819 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750010820 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 315750010821 GntP family permease; Region: GntP_permease; pfam02447 315750010822 fructuronate transporter; Provisional; Region: PRK10034; cl15264 315750010823 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 315750010824 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 315750010825 N- and C-terminal domain interface [polypeptide binding]; other site 315750010826 active site 315750010827 catalytic site [active] 315750010828 metal binding site [ion binding]; metal-binding site 315750010829 carbohydrate binding site [chemical binding]; other site 315750010830 ATP binding site [chemical binding]; other site 315750010831 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750010832 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750010833 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750010834 putative active site [active] 315750010835 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 315750010836 active site 315750010837 tetramer interface [polypeptide binding]; other site 315750010838 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 315750010839 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 315750010840 nucleophilic elbow; other site 315750010841 catalytic triad; other site 315750010842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750010843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750010844 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 315750010845 putative dimerization interface [polypeptide binding]; other site 315750010846 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 315750010847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750010848 DNA binding site [nucleotide binding] 315750010849 domain linker motif; other site 315750010850 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 315750010851 putative dimerization interface [polypeptide binding]; other site 315750010852 putative ligand binding site [chemical binding]; other site 315750010853 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 315750010854 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 315750010855 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750010856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750010857 dimer interface [polypeptide binding]; other site 315750010858 conserved gate region; other site 315750010859 putative PBP binding loops; other site 315750010860 ABC-ATPase subunit interface; other site 315750010861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750010862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750010863 dimer interface [polypeptide binding]; other site 315750010864 conserved gate region; other site 315750010865 putative PBP binding loops; other site 315750010866 ABC-ATPase subunit interface; other site 315750010867 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 315750010868 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 315750010869 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 315750010870 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 315750010871 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 315750010872 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 315750010873 Citrate transporter; Region: CitMHS; pfam03600 315750010874 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 315750010875 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315750010876 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 315750010877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750010878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750010879 Walker A/P-loop; other site 315750010880 ATP binding site [chemical binding]; other site 315750010881 Q-loop/lid; other site 315750010882 ABC transporter signature motif; other site 315750010883 Walker B; other site 315750010884 D-loop; other site 315750010885 H-loop/switch region; other site 315750010886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750010887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750010888 Walker A/P-loop; other site 315750010889 ATP binding site [chemical binding]; other site 315750010890 Q-loop/lid; other site 315750010891 ABC transporter signature motif; other site 315750010892 Walker B; other site 315750010893 D-loop; other site 315750010894 H-loop/switch region; other site 315750010895 LytTr DNA-binding domain; Region: LytTR; smart00850 315750010896 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 315750010897 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 315750010898 PhnA protein; Region: PhnA; pfam03831 315750010899 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 315750010900 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 315750010901 fructuronate transporter; Provisional; Region: PRK10034; cl15264 315750010902 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750010903 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 315750010904 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315750010905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750010906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750010907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010908 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750010909 putative substrate translocation pore; other site 315750010910 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315750010911 FtsX-like permease family; Region: FtsX; pfam02687 315750010912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750010913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315750010914 Walker A/P-loop; other site 315750010915 ATP binding site [chemical binding]; other site 315750010916 Q-loop/lid; other site 315750010917 ABC transporter signature motif; other site 315750010918 Walker B; other site 315750010919 D-loop; other site 315750010920 H-loop/switch region; other site 315750010921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750010922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750010923 TPR motif; other site 315750010924 binding surface 315750010925 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750010926 CAT RNA binding domain; Region: CAT_RBD; smart01061 315750010927 PRD domain; Region: PRD; pfam00874 315750010928 PRD domain; Region: PRD; pfam00874 315750010929 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 315750010930 beta-galactosidase; Region: BGL; TIGR03356 315750010931 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750010932 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750010933 active site turn [active] 315750010934 phosphorylation site [posttranslational modification] 315750010935 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315750010936 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 315750010937 HPr interaction site; other site 315750010938 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750010939 active site 315750010940 phosphorylation site [posttranslational modification] 315750010941 Predicted transcriptional regulators [Transcription]; Region: COG1695 315750010942 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315750010943 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 315750010944 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 315750010945 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 315750010946 putative active site [active] 315750010947 putative CoA binding site [chemical binding]; other site 315750010948 nudix motif; other site 315750010949 metal binding site [ion binding]; metal-binding site 315750010950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750010951 non-specific DNA binding site [nucleotide binding]; other site 315750010952 salt bridge; other site 315750010953 sequence-specific DNA binding site [nucleotide binding]; other site 315750010954 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 315750010955 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750010956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750010957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750010958 DNA binding site [nucleotide binding] 315750010959 domain linker motif; other site 315750010960 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 315750010961 putative dimerization interface [polypeptide binding]; other site 315750010962 putative ligand binding site [chemical binding]; other site 315750010963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750010964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010966 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 315750010967 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 315750010968 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315750010969 shikimate binding site; other site 315750010970 NAD(P) binding site [chemical binding]; other site 315750010971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750010973 putative substrate translocation pore; other site 315750010974 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750010975 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750010976 putative metal binding site [ion binding]; other site 315750010977 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750010978 putative metal binding site [ion binding]; other site 315750010979 Uncharacterized conserved protein [Function unknown]; Region: COG4127 315750010980 Restriction endonuclease; Region: Mrr_cat; pfam04471 315750010981 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750010982 beta-galactosidase; Region: BGL; TIGR03356 315750010983 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750010984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750010985 DNA-binding site [nucleotide binding]; DNA binding site 315750010986 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 315750010987 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 315750010988 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315750010989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750010990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315750010991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750010992 dimerization interface [polypeptide binding]; other site 315750010993 Tubby C 2; Region: Tub_2; cl02043 315750010994 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315750010995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 315750010996 ligand binding site [chemical binding]; other site 315750010997 flexible hinge region; other site 315750010998 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315750010999 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750011000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750011001 ATP binding site [chemical binding]; other site 315750011002 putative Mg++ binding site [ion binding]; other site 315750011003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 315750011004 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 315750011005 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 315750011006 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315750011007 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315750011008 Walker A/P-loop; other site 315750011009 ATP binding site [chemical binding]; other site 315750011010 Q-loop/lid; other site 315750011011 ABC transporter signature motif; other site 315750011012 Walker B; other site 315750011013 D-loop; other site 315750011014 H-loop/switch region; other site 315750011015 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 315750011016 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315750011017 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315750011018 Walker A/P-loop; other site 315750011019 ATP binding site [chemical binding]; other site 315750011020 Q-loop/lid; other site 315750011021 ABC transporter signature motif; other site 315750011022 Walker B; other site 315750011023 D-loop; other site 315750011024 H-loop/switch region; other site 315750011025 hypothetical protein; Provisional; Region: PRK13661 315750011026 Uncharacterized conserved protein [Function unknown]; Region: COG1912 315750011027 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 315750011028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315750011029 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 315750011030 Walker A/P-loop; other site 315750011031 ATP binding site [chemical binding]; other site 315750011032 Q-loop/lid; other site 315750011033 ABC transporter signature motif; other site 315750011034 Walker B; other site 315750011035 D-loop; other site 315750011036 H-loop/switch region; other site 315750011037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750011038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750011039 Coenzyme A binding pocket [chemical binding]; other site 315750011040 serine endoprotease; Provisional; Region: PRK10898 315750011041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 315750011042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750011043 protein binding site [polypeptide binding]; other site 315750011044 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 315750011045 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 315750011046 YycH protein; Region: YycI; cl02015 315750011047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 315750011048 YycH protein; Region: YycH; pfam07435 315750011049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315750011050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750011051 dimerization interface [polypeptide binding]; other site 315750011052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750011053 putative active site [active] 315750011054 heme pocket [chemical binding]; other site 315750011055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750011056 dimer interface [polypeptide binding]; other site 315750011057 phosphorylation site [posttranslational modification] 315750011058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750011059 ATP binding site [chemical binding]; other site 315750011060 Mg2+ binding site [ion binding]; other site 315750011061 G-X-G motif; other site 315750011062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750011063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750011064 active site 315750011065 phosphorylation site [posttranslational modification] 315750011066 intermolecular recognition site; other site 315750011067 dimerization interface [polypeptide binding]; other site 315750011068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750011069 DNA binding site [nucleotide binding] 315750011070 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 315750011071 putative catalytic residues [active] 315750011072 Predicted membrane protein [Function unknown]; Region: COG2311 315750011073 Protein of unknown function (DUF418); Region: DUF418; pfam04235 315750011074 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 315750011075 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 315750011076 GDP-binding site [chemical binding]; other site 315750011077 ACT binding site; other site 315750011078 IMP binding site; other site 315750011079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750011080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315750011081 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315750011082 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 315750011083 Cytochrome P450; Region: p450; cl12078 315750011084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750011085 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315750011086 active site 315750011087 replicative DNA helicase; Provisional; Region: PRK05748 315750011088 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315750011089 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315750011090 Walker A motif; other site 315750011091 ATP binding site [chemical binding]; other site 315750011092 Walker B motif; other site 315750011093 DNA binding loops [nucleotide binding] 315750011094 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750011095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750011096 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750011097 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315750011098 intersubunit interface [polypeptide binding]; other site 315750011099 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750011100 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750011101 putative ligand binding residues [chemical binding]; other site 315750011102 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 315750011103 YycC-like protein; Region: YycC; pfam14174 315750011104 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 315750011105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750011106 putative substrate translocation pore; other site 315750011107 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 315750011108 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 315750011109 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 315750011110 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 315750011111 diguanylate cyclase; Region: GGDEF; smart00267 315750011112 DHH family; Region: DHH; pfam01368 315750011113 DHHA1 domain; Region: DHHA1; pfam02272 315750011114 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 315750011115 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 315750011116 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 315750011117 DHHA2 domain; Region: DHHA2; pfam02833 315750011118 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750011119 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750011120 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315750011121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750011122 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750011123 DNA binding residues [nucleotide binding] 315750011124 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315750011125 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 315750011126 tetramer interface [polypeptide binding]; other site 315750011127 heme binding pocket [chemical binding]; other site 315750011128 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 315750011129 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315750011130 Predicted esterase [General function prediction only]; Region: COG0400 315750011131 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315750011132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750011133 Zn binding site [ion binding]; other site 315750011134 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315750011135 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750011136 Zn binding site [ion binding]; other site 315750011137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750011138 ABC-ATPase subunit interface; other site 315750011139 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315750011140 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 315750011141 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 315750011142 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 315750011143 Walker A/P-loop; other site 315750011144 ATP binding site [chemical binding]; other site 315750011145 Q-loop/lid; other site 315750011146 ABC transporter signature motif; other site 315750011147 Walker B; other site 315750011148 D-loop; other site 315750011149 H-loop/switch region; other site 315750011150 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 315750011151 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 315750011152 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315750011153 dimer interface [polypeptide binding]; other site 315750011154 ssDNA binding site [nucleotide binding]; other site 315750011155 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750011156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 315750011157 GTP-binding protein YchF; Reviewed; Region: PRK09601 315750011158 YchF GTPase; Region: YchF; cd01900 315750011159 G1 box; other site 315750011160 GTP/Mg2+ binding site [chemical binding]; other site 315750011161 Switch I region; other site 315750011162 G2 box; other site 315750011163 Switch II region; other site 315750011164 G3 box; other site 315750011165 G4 box; other site 315750011166 G5 box; other site 315750011167 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 315750011168 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 315750011169 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 315750011170 Uncharacterized membrane protein [Function unknown]; Region: COG3949 315750011171 Spore germination protein; Region: Spore_permease; cl17796 315750011172 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 315750011173 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 315750011174 ParB-like nuclease domain; Region: ParB; smart00470 315750011175 KorB domain; Region: KorB; pfam08535 315750011176 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315750011177 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315750011178 P-loop; other site 315750011179 Magnesium ion binding site [ion binding]; other site 315750011180 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315750011181 Magnesium ion binding site [ion binding]; other site 315750011182 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315750011183 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 315750011184 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 315750011185 ParB-like nuclease domain; Region: ParB; smart00470 315750011186 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 315750011187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750011188 S-adenosylmethionine binding site [chemical binding]; other site 315750011189 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 315750011190 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 315750011191 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 315750011192 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 315750011193 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 315750011194 trmE is a tRNA modification GTPase; Region: trmE; cd04164 315750011195 G1 box; other site 315750011196 GTP/Mg2+ binding site [chemical binding]; other site 315750011197 Switch I region; other site 315750011198 G2 box; other site 315750011199 Switch II region; other site 315750011200 G3 box; other site 315750011201 G4 box; other site 315750011202 G5 box; other site 315750011203 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 315750011204 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 315750011205 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 315750011206 G-X-X-G motif; other site 315750011207 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 315750011208 RxxxH motif; other site 315750011209 OxaA-like protein precursor; Validated; Region: PRK02944 315750011210 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 315750011211 ribonuclease P; Reviewed; Region: rnpA; PRK00499 315750011212 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399