-- dump date   	20140618_223540
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1147161000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1147161000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1147161000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161000004	Walker A motif; other site
1147161000005	ATP binding site [chemical binding]; other site
1147161000006	Walker B motif; other site
1147161000007	arginine finger; other site
1147161000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1147161000009	DnaA box-binding interface [nucleotide binding]; other site
1147161000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1147161000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1147161000012	putative DNA binding surface [nucleotide binding]; other site
1147161000013	dimer interface [polypeptide binding]; other site
1147161000014	beta-clamp/clamp loader binding surface; other site
1147161000015	beta-clamp/translesion DNA polymerase binding surface; other site
1147161000016	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1147161000017	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
1147161000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1147161000019	Walker A/P-loop; other site
1147161000020	ATP binding site [chemical binding]; other site
1147161000021	Q-loop/lid; other site
1147161000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161000023	ABC transporter signature motif; other site
1147161000024	Walker B; other site
1147161000025	D-loop; other site
1147161000026	H-loop/switch region; other site
1147161000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1147161000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161000029	ATP binding site [chemical binding]; other site
1147161000030	Mg2+ binding site [ion binding]; other site
1147161000031	G-X-G motif; other site
1147161000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1147161000033	anchoring element; other site
1147161000034	dimer interface [polypeptide binding]; other site
1147161000035	ATP binding site [chemical binding]; other site
1147161000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1147161000037	active site
1147161000038	putative metal-binding site [ion binding]; other site
1147161000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1147161000040	DNA gyrase subunit A; Validated; Region: PRK05560
1147161000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1147161000042	CAP-like domain; other site
1147161000043	active site
1147161000044	primary dimer interface [polypeptide binding]; other site
1147161000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161000051	YaaC-like Protein; Region: YaaC; pfam14175
1147161000052	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1147161000053	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1147161000054	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1147161000055	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1147161000056	active site
1147161000057	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1147161000058	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1147161000059	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1147161000060	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1147161000061	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1147161000062	active site
1147161000063	multimer interface [polypeptide binding]; other site
1147161000064	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1147161000065	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1147161000066	predicted active site [active]
1147161000067	catalytic triad [active]
1147161000068	seryl-tRNA synthetase; Provisional; Region: PRK05431
1147161000069	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1147161000070	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1147161000071	dimer interface [polypeptide binding]; other site
1147161000072	active site
1147161000073	motif 1; other site
1147161000074	motif 2; other site
1147161000075	motif 3; other site
1147161000076	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1147161000077	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1147161000078	Substrate-binding site [chemical binding]; other site
1147161000079	Substrate specificity [chemical binding]; other site
1147161000080	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1147161000081	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1147161000082	Substrate-binding site [chemical binding]; other site
1147161000083	Substrate specificity [chemical binding]; other site
1147161000084	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1147161000085	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161000086	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161000087	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1147161000088	active site
1147161000089	Isochorismatase family; Region: Isochorismatase; pfam00857
1147161000090	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1147161000091	catalytic triad [active]
1147161000092	conserved cis-peptide bond; other site
1147161000093	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1147161000094	nucleoside/Zn binding site; other site
1147161000095	dimer interface [polypeptide binding]; other site
1147161000096	catalytic motif [active]
1147161000097	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1147161000098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161000099	Walker A motif; other site
1147161000100	ATP binding site [chemical binding]; other site
1147161000101	Walker B motif; other site
1147161000102	arginine finger; other site
1147161000103	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1147161000104	hypothetical protein; Validated; Region: PRK00153
1147161000105	recombination protein RecR; Reviewed; Region: recR; PRK00076
1147161000106	RecR protein; Region: RecR; pfam02132
1147161000107	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1147161000108	putative active site [active]
1147161000109	putative metal-binding site [ion binding]; other site
1147161000110	tetramer interface [polypeptide binding]; other site
1147161000111	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1147161000112	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
1147161000113	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
1147161000114	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1147161000115	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1147161000116	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
1147161000117	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1147161000118	homodimer interface [polypeptide binding]; other site
1147161000119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161000120	catalytic residue [active]
1147161000121	thymidylate kinase; Validated; Region: tmk; PRK00698
1147161000122	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1147161000123	TMP-binding site; other site
1147161000124	ATP-binding site [chemical binding]; other site
1147161000125	Protein of unknown function (DUF970); Region: DUF970; pfam06153
1147161000126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728
1147161000127	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1147161000128	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1147161000129	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1147161000130	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1147161000131	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1147161000132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161000133	S-adenosylmethionine binding site [chemical binding]; other site
1147161000134	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1147161000135	GIY-YIG motif/motif A; other site
1147161000136	putative active site [active]
1147161000137	putative metal binding site [ion binding]; other site
1147161000138	Predicted methyltransferases [General function prediction only]; Region: COG0313
1147161000139	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1147161000140	putative SAM binding site [chemical binding]; other site
1147161000141	putative homodimer interface [polypeptide binding]; other site
1147161000142	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1147161000143	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1147161000144	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1147161000145	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1147161000146	active site
1147161000147	HIGH motif; other site
1147161000148	KMSKS motif; other site
1147161000149	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1147161000150	tRNA binding surface [nucleotide binding]; other site
1147161000151	anticodon binding site; other site
1147161000152	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1147161000153	dimer interface [polypeptide binding]; other site
1147161000154	putative tRNA-binding site [nucleotide binding]; other site
1147161000155	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1147161000156	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1147161000157	active site
1147161000158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1147161000159	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1147161000160	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1147161000161	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1147161000162	G5 domain; Region: G5; pfam07501
1147161000163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1147161000164	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1147161000165	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1147161000166	putative active site [active]
1147161000167	putative metal binding site [ion binding]; other site
1147161000168	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1147161000169	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1147161000170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161000171	S-adenosylmethionine binding site [chemical binding]; other site
1147161000172	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
1147161000173	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1147161000174	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147161000175	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1147161000176	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1147161000177	pur operon repressor; Provisional; Region: PRK09213
1147161000178	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1147161000179	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161000180	active site
1147161000181	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1147161000182	homotrimer interaction site [polypeptide binding]; other site
1147161000183	putative active site [active]
1147161000184	regulatory protein SpoVG; Reviewed; Region: PRK13259
1147161000185	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1147161000186	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1147161000187	Substrate binding site; other site
1147161000188	Mg++ binding site; other site
1147161000189	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1147161000190	active site
1147161000191	substrate binding site [chemical binding]; other site
1147161000192	CoA binding site [chemical binding]; other site
1147161000193	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1147161000194	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1147161000195	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161000196	active site
1147161000197	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1147161000198	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1147161000199	5S rRNA interface [nucleotide binding]; other site
1147161000200	CTC domain interface [polypeptide binding]; other site
1147161000201	L16 interface [polypeptide binding]; other site
1147161000202	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1147161000203	putative active site [active]
1147161000204	catalytic residue [active]
1147161000205	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
1147161000206	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1147161000207	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1147161000208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161000209	ATP binding site [chemical binding]; other site
1147161000210	putative Mg++ binding site [ion binding]; other site
1147161000211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161000212	nucleotide binding region [chemical binding]; other site
1147161000213	ATP-binding site [chemical binding]; other site
1147161000214	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1147161000215	stage V sporulation protein T; Region: spore_V_T; TIGR02851
1147161000216	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1147161000217	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1147161000218	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1147161000219	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1147161000220	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1147161000221	putative SAM binding site [chemical binding]; other site
1147161000222	putative homodimer interface [polypeptide binding]; other site
1147161000223	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1147161000224	homodimer interface [polypeptide binding]; other site
1147161000225	metal binding site [ion binding]; metal-binding site
1147161000226	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1147161000227	homodimer interface [polypeptide binding]; other site
1147161000228	active site
1147161000229	putative chemical substrate binding site [chemical binding]; other site
1147161000230	metal binding site [ion binding]; metal-binding site
1147161000231	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161000232	RNA binding surface [nucleotide binding]; other site
1147161000233	sporulation protein YabP; Region: spore_yabP; TIGR02892
1147161000234	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
1147161000235	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1147161000236	Septum formation initiator; Region: DivIC; pfam04977
1147161000237	hypothetical protein; Provisional; Region: PRK08582
1147161000238	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1147161000239	RNA binding site [nucleotide binding]; other site
1147161000240	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1147161000241	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1147161000242	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1147161000243	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1147161000244	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1147161000245	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1147161000246	metal ion-dependent adhesion site (MIDAS); other site
1147161000247	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1147161000248	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1147161000249	active site
1147161000250	ATP binding site [chemical binding]; other site
1147161000251	substrate binding site [chemical binding]; other site
1147161000252	activation loop (A-loop); other site
1147161000253	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1147161000254	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1147161000255	Ligand Binding Site [chemical binding]; other site
1147161000256	TilS substrate binding domain; Region: TilS; pfam09179
1147161000257	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1147161000258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161000259	active site
1147161000260	FtsH Extracellular; Region: FtsH_ext; pfam06480
1147161000261	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1147161000262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161000263	Walker A motif; other site
1147161000264	ATP binding site [chemical binding]; other site
1147161000265	Walker B motif; other site
1147161000266	arginine finger; other site
1147161000267	Peptidase family M41; Region: Peptidase_M41; pfam01434
1147161000268	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161000269	nucleotide binding site [chemical binding]; other site
1147161000270	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1147161000271	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1147161000272	dimerization interface [polypeptide binding]; other site
1147161000273	domain crossover interface; other site
1147161000274	redox-dependent activation switch; other site
1147161000275	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1147161000276	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1147161000277	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1147161000278	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1147161000279	dimer interface [polypeptide binding]; other site
1147161000280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161000281	catalytic residue [active]
1147161000282	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1147161000283	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1147161000284	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1147161000285	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1147161000286	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1147161000287	glutamine binding [chemical binding]; other site
1147161000288	catalytic triad [active]
1147161000289	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1147161000290	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1147161000291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161000292	catalytic residue [active]
1147161000293	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1147161000294	dihydropteroate synthase; Region: DHPS; TIGR01496
1147161000295	substrate binding pocket [chemical binding]; other site
1147161000296	dimer interface [polypeptide binding]; other site
1147161000297	inhibitor binding site; inhibition site
1147161000298	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1147161000299	homooctamer interface [polypeptide binding]; other site
1147161000300	active site
1147161000301	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1147161000302	catalytic center binding site [active]
1147161000303	ATP binding site [chemical binding]; other site
1147161000304	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161000305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161000306	non-specific DNA binding site [nucleotide binding]; other site
1147161000307	salt bridge; other site
1147161000308	sequence-specific DNA binding site [nucleotide binding]; other site
1147161000309	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1147161000310	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1147161000311	FMN binding site [chemical binding]; other site
1147161000312	active site
1147161000313	catalytic residues [active]
1147161000314	substrate binding site [chemical binding]; other site
1147161000315	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1147161000316	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1147161000317	dimer interface [polypeptide binding]; other site
1147161000318	putative anticodon binding site; other site
1147161000319	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1147161000320	motif 1; other site
1147161000321	active site
1147161000322	motif 2; other site
1147161000323	motif 3; other site
1147161000324	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1147161000325	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1147161000326	UvrB/uvrC motif; Region: UVR; pfam02151
1147161000327	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1147161000328	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1147161000329	ADP binding site [chemical binding]; other site
1147161000330	phosphagen binding site; other site
1147161000331	substrate specificity loop; other site
1147161000332	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1147161000333	Clp amino terminal domain; Region: Clp_N; pfam02861
1147161000334	Clp amino terminal domain; Region: Clp_N; pfam02861
1147161000335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161000336	Walker A motif; other site
1147161000337	ATP binding site [chemical binding]; other site
1147161000338	Walker B motif; other site
1147161000339	arginine finger; other site
1147161000340	UvrB/uvrC motif; Region: UVR; pfam02151
1147161000341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161000342	Walker A motif; other site
1147161000343	ATP binding site [chemical binding]; other site
1147161000344	Walker B motif; other site
1147161000345	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1147161000346	DNA repair protein RadA; Provisional; Region: PRK11823
1147161000347	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1147161000348	Walker A motif/ATP binding site; other site
1147161000349	ATP binding site [chemical binding]; other site
1147161000350	Walker B motif; other site
1147161000351	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1147161000352	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1147161000353	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1147161000354	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1147161000355	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1147161000356	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1147161000357	putative active site [active]
1147161000358	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1147161000359	substrate binding site; other site
1147161000360	dimer interface; other site
1147161000361	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1147161000362	homotrimer interaction site [polypeptide binding]; other site
1147161000363	zinc binding site [ion binding]; other site
1147161000364	CDP-binding sites; other site
1147161000365	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1147161000366	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1147161000367	active site
1147161000368	HIGH motif; other site
1147161000369	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1147161000370	active site
1147161000371	KMSKS motif; other site
1147161000372	serine O-acetyltransferase; Region: cysE; TIGR01172
1147161000373	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1147161000374	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1147161000375	trimer interface [polypeptide binding]; other site
1147161000376	active site
1147161000377	substrate binding site [chemical binding]; other site
1147161000378	CoA binding site [chemical binding]; other site
1147161000379	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1147161000380	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1147161000381	active site
1147161000382	HIGH motif; other site
1147161000383	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1147161000384	KMSKS motif; other site
1147161000385	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1147161000386	tRNA binding surface [nucleotide binding]; other site
1147161000387	anticodon binding site; other site
1147161000388	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1147161000389	active site
1147161000390	metal binding site [ion binding]; metal-binding site
1147161000391	dimerization interface [polypeptide binding]; other site
1147161000392	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1147161000393	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1147161000394	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1147161000395	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1147161000396	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1147161000397	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161000398	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1147161000399	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1147161000400	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1147161000401	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1147161000402	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1147161000403	putative homodimer interface [polypeptide binding]; other site
1147161000404	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1147161000405	heterodimer interface [polypeptide binding]; other site
1147161000406	homodimer interface [polypeptide binding]; other site
1147161000407	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1147161000408	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1147161000409	23S rRNA interface [nucleotide binding]; other site
1147161000410	L7/L12 interface [polypeptide binding]; other site
1147161000411	putative thiostrepton binding site; other site
1147161000412	L25 interface [polypeptide binding]; other site
1147161000413	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1147161000414	mRNA/rRNA interface [nucleotide binding]; other site
1147161000415	L10_leader; BSU6051_0103010
1147161000416	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1147161000417	23S rRNA interface [nucleotide binding]; other site
1147161000418	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1147161000419	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1147161000420	core dimer interface [polypeptide binding]; other site
1147161000421	peripheral dimer interface [polypeptide binding]; other site
1147161000422	L10 interface [polypeptide binding]; other site
1147161000423	L11 interface [polypeptide binding]; other site
1147161000424	putative EF-Tu interaction site [polypeptide binding]; other site
1147161000425	putative EF-G interaction site [polypeptide binding]; other site
1147161000426	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1147161000427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161000428	S-adenosylmethionine binding site [chemical binding]; other site
1147161000429	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1147161000430	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1147161000431	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1147161000432	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1147161000433	RPB1 interaction site [polypeptide binding]; other site
1147161000434	RPB10 interaction site [polypeptide binding]; other site
1147161000435	RPB11 interaction site [polypeptide binding]; other site
1147161000436	RPB3 interaction site [polypeptide binding]; other site
1147161000437	RPB12 interaction site [polypeptide binding]; other site
1147161000438	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1147161000439	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1147161000440	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1147161000441	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1147161000442	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1147161000443	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1147161000444	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1147161000445	G-loop; other site
1147161000446	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1147161000447	DNA binding site [nucleotide binding]
1147161000448	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1147161000449	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
1147161000450	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1147161000451	S17 interaction site [polypeptide binding]; other site
1147161000452	S8 interaction site; other site
1147161000453	16S rRNA interaction site [nucleotide binding]; other site
1147161000454	streptomycin interaction site [chemical binding]; other site
1147161000455	23S rRNA interaction site [nucleotide binding]; other site
1147161000456	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1147161000457	30S ribosomal protein S7; Validated; Region: PRK05302
1147161000458	elongation factor G; Reviewed; Region: PRK00007
1147161000459	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1147161000460	G1 box; other site
1147161000461	putative GEF interaction site [polypeptide binding]; other site
1147161000462	GTP/Mg2+ binding site [chemical binding]; other site
1147161000463	Switch I region; other site
1147161000464	G2 box; other site
1147161000465	G3 box; other site
1147161000466	Switch II region; other site
1147161000467	G4 box; other site
1147161000468	G5 box; other site
1147161000469	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1147161000470	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1147161000471	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1147161000472	elongation factor Tu; Reviewed; Region: PRK00049
1147161000473	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1147161000474	G1 box; other site
1147161000475	GEF interaction site [polypeptide binding]; other site
1147161000476	GTP/Mg2+ binding site [chemical binding]; other site
1147161000477	Switch I region; other site
1147161000478	G2 box; other site
1147161000479	G3 box; other site
1147161000480	Switch II region; other site
1147161000481	G4 box; other site
1147161000482	G5 box; other site
1147161000483	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1147161000484	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1147161000485	Antibiotic Binding Site [chemical binding]; other site
1147161000486	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161000487	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1147161000488	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1147161000489	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1147161000490	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1147161000491	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1147161000492	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1147161000493	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1147161000494	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1147161000495	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1147161000496	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1147161000497	putative translocon binding site; other site
1147161000498	protein-rRNA interface [nucleotide binding]; other site
1147161000499	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1147161000500	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1147161000501	G-X-X-G motif; other site
1147161000502	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1147161000503	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1147161000504	23S rRNA interface [nucleotide binding]; other site
1147161000505	5S rRNA interface [nucleotide binding]; other site
1147161000506	putative antibiotic binding site [chemical binding]; other site
1147161000507	L25 interface [polypeptide binding]; other site
1147161000508	L27 interface [polypeptide binding]; other site
1147161000509	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1147161000510	23S rRNA interface [nucleotide binding]; other site
1147161000511	putative translocon interaction site; other site
1147161000512	signal recognition particle (SRP54) interaction site; other site
1147161000513	L23 interface [polypeptide binding]; other site
1147161000514	trigger factor interaction site; other site
1147161000515	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1147161000516	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1147161000517	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1147161000518	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1147161000519	RNA binding site [nucleotide binding]; other site
1147161000520	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1147161000521	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1147161000522	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1147161000523	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1147161000524	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1147161000525	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1147161000526	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1147161000527	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1147161000528	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1147161000529	5S rRNA interface [nucleotide binding]; other site
1147161000530	L27 interface [polypeptide binding]; other site
1147161000531	23S rRNA interface [nucleotide binding]; other site
1147161000532	L5 interface [polypeptide binding]; other site
1147161000533	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1147161000534	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1147161000535	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1147161000536	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1147161000537	23S rRNA binding site [nucleotide binding]; other site
1147161000538	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1147161000539	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1147161000540	SecY translocase; Region: SecY; pfam00344
1147161000541	adenylate kinase; Reviewed; Region: adk; PRK00279
1147161000542	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1147161000543	AMP-binding site [chemical binding]; other site
1147161000544	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1147161000545	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1147161000546	active site
1147161000547	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
1147161000548	RNA binding site [nucleotide binding]; other site
1147161000549	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1147161000550	rRNA binding site [nucleotide binding]; other site
1147161000551	predicted 30S ribosome binding site; other site
1147161000552	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1147161000553	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1147161000554	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1147161000555	30S ribosomal protein S11; Validated; Region: PRK05309
1147161000556	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1147161000557	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1147161000558	alphaNTD homodimer interface [polypeptide binding]; other site
1147161000559	alphaNTD - beta interaction site [polypeptide binding]; other site
1147161000560	alphaNTD - beta' interaction site [polypeptide binding]; other site
1147161000561	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1147161000562	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1147161000563	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1147161000564	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147161000565	Walker A/P-loop; other site
1147161000566	ATP binding site [chemical binding]; other site
1147161000567	Q-loop/lid; other site
1147161000568	ABC transporter signature motif; other site
1147161000569	Walker B; other site
1147161000570	D-loop; other site
1147161000571	H-loop/switch region; other site
1147161000572	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1147161000573	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147161000574	Walker A/P-loop; other site
1147161000575	ATP binding site [chemical binding]; other site
1147161000576	Q-loop/lid; other site
1147161000577	ABC transporter signature motif; other site
1147161000578	Walker B; other site
1147161000579	D-loop; other site
1147161000580	H-loop/switch region; other site
1147161000581	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1147161000582	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1147161000583	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1147161000584	dimerization interface 3.5A [polypeptide binding]; other site
1147161000585	active site
1147161000586	L13_leader; BSU6051_0148010
1147161000587	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1147161000588	23S rRNA interface [nucleotide binding]; other site
1147161000589	L3 interface [polypeptide binding]; other site
1147161000590	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1147161000591	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1147161000592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161000593	S-adenosylmethionine binding site [chemical binding]; other site
1147161000594	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
1147161000595	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1147161000596	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1147161000597	active site
1147161000598	metal binding site [ion binding]; metal-binding site
1147161000599	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1147161000600	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1147161000601	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
1147161000602	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1147161000603	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
1147161000604	NodB motif; other site
1147161000605	putative active site [active]
1147161000606	putative catalytic site [active]
1147161000607	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1147161000608	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1147161000609	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1147161000610	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1147161000611	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1147161000612	Sodium Bile acid symporter family; Region: SBF; cl17470
1147161000613	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1147161000614	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1147161000615	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161000616	dimer interface [polypeptide binding]; other site
1147161000617	putative PBP binding regions; other site
1147161000618	ABC-ATPase subunit  interface; other site
1147161000619	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1147161000620	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1147161000621	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161000622	ABC-ATPase subunit  interface; other site
1147161000623	dimer interface [polypeptide binding]; other site
1147161000624	putative PBP binding regions; other site
1147161000625	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1147161000626	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1147161000627	putative ligand binding residues [chemical binding]; other site
1147161000628	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161000629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161000630	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1147161000631	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1147161000632	putative ligand binding residues [chemical binding]; other site
1147161000633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876
1147161000634	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1147161000635	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1147161000636	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1147161000637	putative periplasmic esterase; Provisional; Region: PRK03642
1147161000638	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1147161000639	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1147161000640	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161000641	active site turn [active]
1147161000642	phosphorylation site [posttranslational modification]
1147161000643	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161000644	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1147161000645	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1147161000646	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1147161000647	putative active site [active]
1147161000648	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
1147161000649	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1147161000650	putative active site [active]
1147161000651	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1147161000652	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1147161000653	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
1147161000654	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161000655	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161000656	DNA binding residues [nucleotide binding]
1147161000657	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1147161000658	Putative zinc-finger; Region: zf-HC2; pfam13490
1147161000659	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1147161000660	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1147161000661	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1147161000662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1147161000663	YbbR-like protein; Region: YbbR; pfam07949
1147161000664	YbbR-like protein; Region: YbbR; pfam07949
1147161000665	YbbR-like protein; Region: YbbR; pfam07949
1147161000666	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1147161000667	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1147161000668	active site
1147161000669	substrate binding site [chemical binding]; other site
1147161000670	metal binding site [ion binding]; metal-binding site
1147161000671	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1147161000672	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1147161000673	glutaminase active site [active]
1147161000674	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1147161000675	dimer interface [polypeptide binding]; other site
1147161000676	active site
1147161000677	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1147161000678	dimer interface [polypeptide binding]; other site
1147161000679	active site
1147161000680	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
1147161000681	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1147161000682	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1147161000683	minor groove reading motif; other site
1147161000684	helix-hairpin-helix signature motif; other site
1147161000685	substrate binding pocket [chemical binding]; other site
1147161000686	active site
1147161000687	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1147161000688	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1147161000689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161000690	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161000691	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1147161000692	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1147161000693	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1147161000694	DNA binding site [nucleotide binding]
1147161000695	active site
1147161000696	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1147161000697	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147161000698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1147161000699	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1147161000700	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
1147161000701	zinc binding site [ion binding]; other site
1147161000702	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1147161000703	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161000704	dimerization interface [polypeptide binding]; other site
1147161000705	putative DNA binding site [nucleotide binding]; other site
1147161000706	putative Zn2+ binding site [ion binding]; other site
1147161000707	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161000708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000709	putative substrate translocation pore; other site
1147161000710	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449
1147161000711	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161000712	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1147161000713	FeS/SAM binding site; other site
1147161000714	CAAX protease self-immunity; Region: Abi; pfam02517
1147161000715	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1147161000716	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161000717	Walker A/P-loop; other site
1147161000718	ATP binding site [chemical binding]; other site
1147161000719	Q-loop/lid; other site
1147161000720	ABC transporter signature motif; other site
1147161000721	Walker B; other site
1147161000722	D-loop; other site
1147161000723	H-loop/switch region; other site
1147161000724	HEAT repeats; Region: HEAT_2; pfam13646
1147161000725	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161000726	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1147161000727	catalytic residues [active]
1147161000728	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161000729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161000730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161000731	active site
1147161000732	phosphorylation site [posttranslational modification]
1147161000733	intermolecular recognition site; other site
1147161000734	dimerization interface [polypeptide binding]; other site
1147161000735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161000736	DNA binding site [nucleotide binding]
1147161000737	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161000738	HAMP domain; Region: HAMP; pfam00672
1147161000739	dimerization interface [polypeptide binding]; other site
1147161000740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161000741	dimer interface [polypeptide binding]; other site
1147161000742	phosphorylation site [posttranslational modification]
1147161000743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161000744	ATP binding site [chemical binding]; other site
1147161000745	Mg2+ binding site [ion binding]; other site
1147161000746	G-X-G motif; other site
1147161000747	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1147161000748	active site
1147161000749	ATP binding site [chemical binding]; other site
1147161000750	substrate binding site [chemical binding]; other site
1147161000751	activation loop (A-loop); other site
1147161000752	putative transport protein YifK; Provisional; Region: PRK10746
1147161000753	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1147161000754	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161000755	Cytochrome P450; Region: p450; cl12078
1147161000756	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1147161000757	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1147161000758	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1147161000759	active site
1147161000760	catalytic site [active]
1147161000761	metal binding site [ion binding]; metal-binding site
1147161000762	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
1147161000763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000764	putative substrate translocation pore; other site
1147161000765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000766	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1147161000767	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161000768	MarR family; Region: MarR; pfam01047
1147161000769	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1147161000770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161000771	Coenzyme A binding pocket [chemical binding]; other site
1147161000772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000773	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161000774	putative substrate translocation pore; other site
1147161000775	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147161000776	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161000777	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147161000778	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161000779	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1147161000780	active site
1147161000781	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161000782	EamA-like transporter family; Region: EamA; pfam00892
1147161000783	EamA-like transporter family; Region: EamA; pfam00892
1147161000784	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1147161000785	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161000786	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161000787	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161000788	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1147161000789	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161000790	ATP-grasp domain; Region: ATP-grasp; pfam02222
1147161000791	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1147161000792	Protein of unknown function (DUF2606); Region: DUF2606; pfam10794
1147161000793	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161000794	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1147161000795	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1147161000796	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1147161000797	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1147161000798	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
1147161000799	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
1147161000800	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161000801	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161000802	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1147161000803	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1147161000804	active site residue [active]
1147161000805	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1147161000806	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1147161000807	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1147161000808	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161000809	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1147161000810	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161000811	active site turn [active]
1147161000812	phosphorylation site [posttranslational modification]
1147161000813	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1147161000814	HPr interaction site; other site
1147161000815	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1147161000816	active site
1147161000817	phosphorylation site [posttranslational modification]
1147161000818	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1147161000819	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1147161000820	active site
1147161000821	trimer interface [polypeptide binding]; other site
1147161000822	allosteric site; other site
1147161000823	active site lid [active]
1147161000824	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1147161000825	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147161000826	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161000827	DNA-binding site [nucleotide binding]; DNA binding site
1147161000828	UTRA domain; Region: UTRA; pfam07702
1147161000829	Predicted integral membrane protein [Function unknown]; Region: COG5658
1147161000830	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1147161000831	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1147161000832	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1147161000833	homodimer interface [polypeptide binding]; other site
1147161000834	substrate-cofactor binding pocket; other site
1147161000835	catalytic residue [active]
1147161000836	S-methylmethionine transporter; Provisional; Region: PRK11387
1147161000837	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1147161000838	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1147161000839	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1147161000840	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1147161000841	glutaminase; Reviewed; Region: PRK12357
1147161000842	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1147161000843	Chorismate mutase type II; Region: CM_2; cl00693
1147161000844	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161000845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161000846	ATP binding site [chemical binding]; other site
1147161000847	Mg2+ binding site [ion binding]; other site
1147161000848	G-X-G motif; other site
1147161000849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161000850	Response regulator receiver domain; Region: Response_reg; pfam00072
1147161000851	active site
1147161000852	phosphorylation site [posttranslational modification]
1147161000853	intermolecular recognition site; other site
1147161000854	dimerization interface [polypeptide binding]; other site
1147161000855	YcbB domain; Region: YcbB; pfam08664
1147161000856	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1147161000857	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1147161000858	putative active site [active]
1147161000859	catalytic residue [active]
1147161000860	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1147161000861	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1147161000862	NAD(P) binding site [chemical binding]; other site
1147161000863	catalytic residues [active]
1147161000864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000865	D-galactonate transporter; Region: 2A0114; TIGR00893
1147161000866	putative substrate translocation pore; other site
1147161000867	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1147161000868	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1147161000869	active site
1147161000870	tetramer interface [polypeptide binding]; other site
1147161000871	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1147161000872	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161000873	DNA-binding site [nucleotide binding]; DNA binding site
1147161000874	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1147161000875	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1147161000876	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1147161000877	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1147161000878	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
1147161000879	putative active site [active]
1147161000880	putative substrate binding site [chemical binding]; other site
1147161000881	Phosphotransferase enzyme family; Region: APH; pfam01636
1147161000882	ATP binding site [chemical binding]; other site
1147161000883	anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748
1147161000884	dodecamer interface 1 [polypeptide binding]; other site
1147161000885	dodecamer interface 2 [polypeptide binding]; other site
1147161000886	trimer interface [polypeptide binding]; other site
1147161000887	TRAP binding interface [polypeptide binding]; other site
1147161000888	Zn binding site [ion binding]; other site
1147161000889	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161000890	EamA-like transporter family; Region: EamA; pfam00892
1147161000891	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161000892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161000893	active site
1147161000894	phosphorylation site [posttranslational modification]
1147161000895	intermolecular recognition site; other site
1147161000896	dimerization interface [polypeptide binding]; other site
1147161000897	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161000898	DNA binding site [nucleotide binding]
1147161000899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161000900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161000901	dimer interface [polypeptide binding]; other site
1147161000902	phosphorylation site [posttranslational modification]
1147161000903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161000904	ATP binding site [chemical binding]; other site
1147161000905	Mg2+ binding site [ion binding]; other site
1147161000906	G-X-G motif; other site
1147161000907	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161000908	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1147161000909	Walker A/P-loop; other site
1147161000910	ATP binding site [chemical binding]; other site
1147161000911	Q-loop/lid; other site
1147161000912	ABC transporter signature motif; other site
1147161000913	Walker B; other site
1147161000914	D-loop; other site
1147161000915	H-loop/switch region; other site
1147161000916	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1147161000917	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1147161000918	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1147161000919	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1147161000920	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1147161000921	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1147161000922	metal ion-dependent adhesion site (MIDAS); other site
1147161000923	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1147161000924	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1147161000925	putative active site [active]
1147161000926	putative metal binding site [ion binding]; other site
1147161000927	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1147161000928	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1147161000929	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1147161000930	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1147161000931	putative substrate binding pocket [chemical binding]; other site
1147161000932	AC domain interface; other site
1147161000933	catalytic triad [active]
1147161000934	AB domain interface; other site
1147161000935	interchain disulfide; other site
1147161000936	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1147161000937	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1147161000938	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161000939	catalytic residue [active]
1147161000940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000941	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161000942	putative substrate translocation pore; other site
1147161000943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161000944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161000945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161000946	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1147161000947	active site
1147161000948	homotetramer interface [polypeptide binding]; other site
1147161000949	homodimer interface [polypeptide binding]; other site
1147161000950	Lipase (class 2); Region: Lipase_2; pfam01674
1147161000951	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1147161000952	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1147161000953	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
1147161000954	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
1147161000955	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1147161000956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161000957	ATP binding site [chemical binding]; other site
1147161000958	Mg2+ binding site [ion binding]; other site
1147161000959	G-X-G motif; other site
1147161000960	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1147161000961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161000962	active site
1147161000963	phosphorylation site [posttranslational modification]
1147161000964	intermolecular recognition site; other site
1147161000965	dimerization interface [polypeptide binding]; other site
1147161000966	LytTr DNA-binding domain; Region: LytTR; pfam04397
1147161000967	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1147161000968	ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266
1147161000969	Walker A/P-loop; other site
1147161000970	ATP binding site [chemical binding]; other site
1147161000971	Q-loop/lid; other site
1147161000972	ABC transporter signature motif; other site
1147161000973	Walker B; other site
1147161000974	D-loop; other site
1147161000975	H-loop/switch region; other site
1147161000976	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1147161000977	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147161000978	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161000979	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161000980	active site
1147161000981	catalytic tetrad [active]
1147161000982	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1147161000983	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147161000984	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1147161000985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161000986	binding surface
1147161000987	TPR motif; other site
1147161000988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161000989	TPR motif; other site
1147161000990	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161000991	binding surface
1147161000992	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1147161000993	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1147161000994	NAD binding site [chemical binding]; other site
1147161000995	homodimer interface [polypeptide binding]; other site
1147161000996	active site
1147161000997	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1147161000998	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1147161000999	Ca binding site [ion binding]; other site
1147161001000	active site
1147161001001	catalytic site [active]
1147161001002	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1147161001003	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1147161001004	metal binding site [ion binding]; metal-binding site
1147161001005	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1147161001006	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1147161001007	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1147161001008	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161001009	ABC-ATPase subunit  interface; other site
1147161001010	dimer interface [polypeptide binding]; other site
1147161001011	putative PBP binding regions; other site
1147161001012	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1147161001013	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1147161001014	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1147161001015	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1147161001016	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1147161001017	putative metal binding site [ion binding]; other site
1147161001018	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1147161001019	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1147161001020	putative metal binding site [ion binding]; other site
1147161001021	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1147161001022	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1147161001023	putative metal binding site [ion binding]; other site
1147161001024	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1147161001025	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
1147161001026	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
1147161001027	benzoate transport; Region: 2A0115; TIGR00895
1147161001028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001029	putative substrate translocation pore; other site
1147161001030	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161001031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001032	putative substrate translocation pore; other site
1147161001033	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161001034	dimerization interface [polypeptide binding]; other site
1147161001035	putative DNA binding site [nucleotide binding]; other site
1147161001036	putative Zn2+ binding site [ion binding]; other site
1147161001037	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1147161001038	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1147161001039	Walker A/P-loop; other site
1147161001040	ATP binding site [chemical binding]; other site
1147161001041	Q-loop/lid; other site
1147161001042	ABC transporter signature motif; other site
1147161001043	Walker B; other site
1147161001044	D-loop; other site
1147161001045	H-loop/switch region; other site
1147161001046	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1147161001047	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1147161001048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161001049	dimer interface [polypeptide binding]; other site
1147161001050	conserved gate region; other site
1147161001051	putative PBP binding loops; other site
1147161001052	ABC-ATPase subunit interface; other site
1147161001053	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1147161001054	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1147161001055	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1147161001056	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
1147161001057	amidohydrolase; Region: amidohydrolases; TIGR01891
1147161001058	metal binding site [ion binding]; metal-binding site
1147161001059	putative dimer interface [polypeptide binding]; other site
1147161001060	Predicted membrane protein [Function unknown]; Region: COG1288
1147161001061	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1147161001062	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
1147161001063	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1147161001064	active site
1147161001065	Ca binding site [ion binding]; other site
1147161001066	catalytic site [active]
1147161001067	Aamy_C domain; Region: Aamy_C; smart00632
1147161001068	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1147161001069	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1147161001070	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161001071	NAD binding site [chemical binding]; other site
1147161001072	dimer interface [polypeptide binding]; other site
1147161001073	substrate binding site [chemical binding]; other site
1147161001074	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1147161001075	L-lactate permease; Region: Lactate_perm; pfam02652
1147161001076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001077	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161001078	putative substrate translocation pore; other site
1147161001079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001080	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161001081	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161001082	putative DNA binding site [nucleotide binding]; other site
1147161001083	putative Zn2+ binding site [ion binding]; other site
1147161001084	LysE type translocator; Region: LysE; pfam01810
1147161001085	Uncharacterized conserved protein [Function unknown]; Region: COG3403
1147161001086	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1147161001087	Spore germination protein; Region: Spore_permease; cl17796
1147161001088	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1147161001089	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1147161001090	NAD+ synthetase; Region: nadE; TIGR00552
1147161001091	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1147161001092	homodimer interface [polypeptide binding]; other site
1147161001093	NAD binding pocket [chemical binding]; other site
1147161001094	ATP binding pocket [chemical binding]; other site
1147161001095	Mg binding site [ion binding]; other site
1147161001096	active-site loop [active]
1147161001097	AAA domain; Region: AAA_17; cl17253
1147161001098	AAA domain; Region: AAA_18; pfam13238
1147161001099	shikimate kinase; Reviewed; Region: aroK; PRK00131
1147161001100	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1147161001101	ADP binding site [chemical binding]; other site
1147161001102	magnesium binding site [ion binding]; other site
1147161001103	putative shikimate binding site; other site
1147161001104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161001105	S-adenosylmethionine binding site [chemical binding]; other site
1147161001106	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161001107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161001108	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161001109	dimerization interface [polypeptide binding]; other site
1147161001110	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1147161001111	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1147161001112	Proline dehydrogenase; Region: Pro_dh; pfam01619
1147161001113	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1147161001114	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1147161001115	Glutamate binding site [chemical binding]; other site
1147161001116	homodimer interface [polypeptide binding]; other site
1147161001117	NAD binding site [chemical binding]; other site
1147161001118	catalytic residues [active]
1147161001119	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1147161001120	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147161001121	Predicted membrane protein [Function unknown]; Region: COG3689
1147161001122	Predicted permeases [General function prediction only]; Region: COG0701
1147161001123	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161001124	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1147161001125	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147161001126	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161001127	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1147161001128	active site
1147161001129	SAM binding site [chemical binding]; other site
1147161001130	homodimer interface [polypeptide binding]; other site
1147161001131	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1147161001132	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1147161001133	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1147161001134	[2Fe-2S] cluster binding site [ion binding]; other site
1147161001135	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
1147161001136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161001137	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1147161001138	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1147161001139	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1147161001140	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1147161001141	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1147161001142	[4Fe-4S] binding site [ion binding]; other site
1147161001143	molybdopterin cofactor binding site; other site
1147161001144	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1147161001145	molybdopterin cofactor binding site; other site
1147161001146	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
1147161001147	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161001148	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1147161001149	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1147161001150	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1147161001151	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1147161001152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001153	putative substrate translocation pore; other site
1147161001154	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
1147161001155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1147161001156	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1147161001157	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1147161001158	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1147161001159	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1147161001160	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1147161001161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161001162	dimer interface [polypeptide binding]; other site
1147161001163	conserved gate region; other site
1147161001164	putative PBP binding loops; other site
1147161001165	ABC-ATPase subunit interface; other site
1147161001166	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1147161001167	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161001168	substrate binding pocket [chemical binding]; other site
1147161001169	membrane-bound complex binding site; other site
1147161001170	hinge residues; other site
1147161001171	RDD family; Region: RDD; pfam06271
1147161001172	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
1147161001173	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1147161001174	beta-galactosidase; Region: BGL; TIGR03356
1147161001175	Competence protein J (ComJ); Region: ComJ; pfam11033
1147161001176	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1147161001177	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161001178	dimerization interface [polypeptide binding]; other site
1147161001179	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161001180	dimer interface [polypeptide binding]; other site
1147161001181	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1147161001182	putative CheW interface [polypeptide binding]; other site
1147161001183	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1147161001184	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1147161001185	tetramer interface [polypeptide binding]; other site
1147161001186	active site
1147161001187	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1147161001188	active site
1147161001189	dimer interface [polypeptide binding]; other site
1147161001190	magnesium binding site [ion binding]; other site
1147161001191	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161001192	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161001193	Condensation domain; Region: Condensation; pfam00668
1147161001194	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001195	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161001196	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161001197	acyl-activating enzyme (AAE) consensus motif; other site
1147161001198	AMP binding site [chemical binding]; other site
1147161001199	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001200	Condensation domain; Region: Condensation; pfam00668
1147161001201	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001202	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161001203	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1147161001204	acyl-activating enzyme (AAE) consensus motif; other site
1147161001205	AMP binding site [chemical binding]; other site
1147161001206	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001207	Condensation domain; Region: Condensation; pfam00668
1147161001208	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001209	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161001210	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161001211	acyl-activating enzyme (AAE) consensus motif; other site
1147161001212	AMP binding site [chemical binding]; other site
1147161001213	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001214	Condensation domain; Region: Condensation; pfam00668
1147161001215	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001216	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161001217	Condensation domain; Region: Condensation; pfam00668
1147161001218	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001219	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1147161001220	acyl-activating enzyme (AAE) consensus motif; other site
1147161001221	AMP binding site [chemical binding]; other site
1147161001222	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001223	Condensation domain; Region: Condensation; pfam00668
1147161001224	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001225	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161001226	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161001227	acyl-activating enzyme (AAE) consensus motif; other site
1147161001228	AMP binding site [chemical binding]; other site
1147161001229	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001230	Condensation domain; Region: Condensation; pfam00668
1147161001231	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001232	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161001233	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161001234	acyl-activating enzyme (AAE) consensus motif; other site
1147161001235	AMP binding site [chemical binding]; other site
1147161001236	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001237	Condensation domain; Region: Condensation; pfam00668
1147161001238	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161001239	Condensation domain; Region: Condensation; pfam00668
1147161001240	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161001241	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1147161001242	acyl-activating enzyme (AAE) consensus motif; other site
1147161001243	AMP binding site [chemical binding]; other site
1147161001244	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161001245	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1147161001246	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1147161001247	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
1147161001248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001249	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161001250	putative substrate translocation pore; other site
1147161001251	YcxB-like protein; Region: YcxB; pfam14317
1147161001252	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161001253	EamA-like transporter family; Region: EamA; pfam00892
1147161001254	EamA-like transporter family; Region: EamA; pfam00892
1147161001255	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161001256	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001257	DNA-binding site [nucleotide binding]; DNA binding site
1147161001258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161001259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161001260	homodimer interface [polypeptide binding]; other site
1147161001261	catalytic residue [active]
1147161001262	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1147161001263	phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556
1147161001264	Predicted membrane protein [Function unknown]; Region: COG2364
1147161001265	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161001266	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1147161001267	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1147161001268	Walker A/P-loop; other site
1147161001269	ATP binding site [chemical binding]; other site
1147161001270	Q-loop/lid; other site
1147161001271	ABC transporter signature motif; other site
1147161001272	Walker B; other site
1147161001273	D-loop; other site
1147161001274	H-loop/switch region; other site
1147161001275	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1147161001276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161001277	dimer interface [polypeptide binding]; other site
1147161001278	conserved gate region; other site
1147161001279	putative PBP binding loops; other site
1147161001280	ABC-ATPase subunit interface; other site
1147161001281	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1147161001282	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161001283	substrate binding pocket [chemical binding]; other site
1147161001284	membrane-bound complex binding site; other site
1147161001285	hinge residues; other site
1147161001286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161001287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161001288	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161001289	dimerization interface [polypeptide binding]; other site
1147161001290	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
1147161001291	Flavoprotein; Region: Flavoprotein; pfam02441
1147161001292	UbiD family decarboxylase; Region: TIGR00148
1147161001293	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1147161001294	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161001295	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1147161001296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001297	putative substrate translocation pore; other site
1147161001298	POT family; Region: PTR2; pfam00854
1147161001299	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1147161001300	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
1147161001301	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147161001302	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147161001303	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147161001304	Spore germination protein; Region: Spore_permease; pfam03845
1147161001305	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161001306	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161001307	Walker A/P-loop; other site
1147161001308	ATP binding site [chemical binding]; other site
1147161001309	Q-loop/lid; other site
1147161001310	ABC transporter signature motif; other site
1147161001311	Walker B; other site
1147161001312	D-loop; other site
1147161001313	H-loop/switch region; other site
1147161001314	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1147161001315	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147161001316	FtsX-like permease family; Region: FtsX; pfam02687
1147161001317	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161001318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161001319	active site
1147161001320	phosphorylation site [posttranslational modification]
1147161001321	intermolecular recognition site; other site
1147161001322	dimerization interface [polypeptide binding]; other site
1147161001323	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161001324	DNA binding site [nucleotide binding]
1147161001325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161001326	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161001327	dimerization interface [polypeptide binding]; other site
1147161001328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161001329	dimer interface [polypeptide binding]; other site
1147161001330	phosphorylation site [posttranslational modification]
1147161001331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161001332	ATP binding site [chemical binding]; other site
1147161001333	Mg2+ binding site [ion binding]; other site
1147161001334	G-X-G motif; other site
1147161001335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161001336	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161001337	TPR motif; other site
1147161001338	binding surface
1147161001339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161001340	Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131
1147161001341	aspartate kinase; Reviewed; Region: PRK09034
1147161001342	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1147161001343	putative catalytic residues [active]
1147161001344	putative nucleotide binding site [chemical binding]; other site
1147161001345	putative aspartate binding site [chemical binding]; other site
1147161001346	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1147161001347	allosteric regulatory residue; other site
1147161001348	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1147161001349	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1147161001350	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161001351	ABC-ATPase subunit  interface; other site
1147161001352	dimer interface [polypeptide binding]; other site
1147161001353	putative PBP binding regions; other site
1147161001354	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161001355	ABC-ATPase subunit  interface; other site
1147161001356	dimer interface [polypeptide binding]; other site
1147161001357	putative PBP binding regions; other site
1147161001358	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1147161001359	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1147161001360	Walker A/P-loop; other site
1147161001361	ATP binding site [chemical binding]; other site
1147161001362	Q-loop/lid; other site
1147161001363	ABC transporter signature motif; other site
1147161001364	Walker B; other site
1147161001365	D-loop; other site
1147161001366	H-loop/switch region; other site
1147161001367	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1147161001368	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1147161001369	putative ligand binding residues [chemical binding]; other site
1147161001370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001371	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161001372	putative substrate translocation pore; other site
1147161001373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001374	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161001375	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161001376	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1147161001377	dimer interface [polypeptide binding]; other site
1147161001378	FMN binding site [chemical binding]; other site
1147161001379	NADPH bind site [chemical binding]; other site
1147161001380	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1147161001381	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161001382	dimerization interface [polypeptide binding]; other site
1147161001383	putative DNA binding site [nucleotide binding]; other site
1147161001384	putative Zn2+ binding site [ion binding]; other site
1147161001385	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161001386	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001387	DNA-binding site [nucleotide binding]; DNA binding site
1147161001388	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161001389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161001390	homodimer interface [polypeptide binding]; other site
1147161001391	catalytic residue [active]
1147161001392	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
1147161001393	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161001394	inhibitor-cofactor binding pocket; inhibition site
1147161001395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161001396	catalytic residue [active]
1147161001397	succinic semialdehyde dehydrogenase; Region: PLN02278
1147161001398	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1147161001399	tetramerization interface [polypeptide binding]; other site
1147161001400	NAD(P) binding site [chemical binding]; other site
1147161001401	catalytic residues [active]
1147161001402	Sugar transport protein; Region: Sugar_transport; pfam06800
1147161001403	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1147161001404	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1147161001405	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1147161001406	NAD binding site [chemical binding]; other site
1147161001407	homodimer interface [polypeptide binding]; other site
1147161001408	active site
1147161001409	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1147161001410	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1147161001411	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1147161001412	YtkA-like; Region: YtkA; pfam13115
1147161001413	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147161001414	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1147161001415	NosL; Region: NosL; cl01769
1147161001416	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1147161001417	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1147161001418	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1147161001419	active site
1147161001420	P-loop; other site
1147161001421	phosphorylation site [posttranslational modification]
1147161001422	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1147161001423	active site
1147161001424	phosphorylation site [posttranslational modification]
1147161001425	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1147161001426	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1147161001427	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1147161001428	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1147161001429	tartrate dehydrogenase; Provisional; Region: PRK08194
1147161001430	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1147161001431	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147161001432	Catalytic site [active]
1147161001433	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1147161001434	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1147161001435	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1147161001436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161001437	active site
1147161001438	motif I; other site
1147161001439	motif II; other site
1147161001440	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161001441	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1147161001442	putative active site [active]
1147161001443	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1147161001444	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1147161001445	hypothetical protein; Provisional; Region: PRK05463
1147161001446	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1147161001447	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1147161001448	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1147161001449	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1147161001450	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1147161001451	Bacterial transcriptional regulator; Region: IclR; pfam01614
1147161001452	Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755
1147161001453	active site
1147161001454	catalytic triad [active]
1147161001455	oxyanion hole [active]
1147161001456	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
1147161001457	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1147161001458	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1147161001459	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1147161001460	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161001461	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161001462	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161001463	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161001464	active site
1147161001465	catalytic tetrad [active]
1147161001466	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1147161001467	HTH domain; Region: HTH_11; pfam08279
1147161001468	PRD domain; Region: PRD; pfam00874
1147161001469	PRD domain; Region: PRD; pfam00874
1147161001470	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1147161001471	active site
1147161001472	P-loop; other site
1147161001473	phosphorylation site [posttranslational modification]
1147161001474	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1147161001475	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1147161001476	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1147161001477	acyl-activating enzyme (AAE) consensus motif; other site
1147161001478	putative AMP binding site [chemical binding]; other site
1147161001479	putative active site [active]
1147161001480	putative CoA binding site [chemical binding]; other site
1147161001481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161001482	S-adenosylmethionine binding site [chemical binding]; other site
1147161001483	short chain dehydrogenase; Provisional; Region: PRK06701
1147161001484	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1147161001485	NAD binding site [chemical binding]; other site
1147161001486	metal binding site [ion binding]; metal-binding site
1147161001487	active site
1147161001488	ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822
1147161001489	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161001490	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1147161001491	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1147161001492	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1147161001493	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1147161001494	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1147161001495	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1147161001496	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1147161001497	putative DNA binding site [nucleotide binding]; other site
1147161001498	putative Zn2+ binding site [ion binding]; other site
1147161001499	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161001500	DNA topoisomerase III; Provisional; Region: PRK07726
1147161001501	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1147161001502	active site
1147161001503	putative interdomain interaction site [polypeptide binding]; other site
1147161001504	putative metal-binding site [ion binding]; other site
1147161001505	putative nucleotide binding site [chemical binding]; other site
1147161001506	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1147161001507	domain I; other site
1147161001508	DNA binding groove [nucleotide binding]
1147161001509	phosphate binding site [ion binding]; other site
1147161001510	domain II; other site
1147161001511	domain III; other site
1147161001512	nucleotide binding site [chemical binding]; other site
1147161001513	catalytic site [active]
1147161001514	domain IV; other site
1147161001515	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1147161001516	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1147161001517	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147161001518	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147161001519	metal binding site [ion binding]; metal-binding site
1147161001520	active site
1147161001521	I-site; other site
1147161001522	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
1147161001523	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1147161001524	NodB motif; other site
1147161001525	putative active site [active]
1147161001526	putative catalytic site [active]
1147161001527	putative Zn binding site [ion binding]; other site
1147161001528	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1147161001529	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1147161001530	DXD motif; other site
1147161001531	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1147161001532	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1147161001533	ydaO-yuaA; BSU6051_0431010
1147161001534	Amino acid permease; Region: AA_permease_2; pfam13520
1147161001535	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1147161001536	nudix motif; other site
1147161001537	pyruvate oxidase; Provisional; Region: PRK08611
1147161001538	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1147161001539	PYR/PP interface [polypeptide binding]; other site
1147161001540	tetramer interface [polypeptide binding]; other site
1147161001541	dimer interface [polypeptide binding]; other site
1147161001542	TPP binding site [chemical binding]; other site
1147161001543	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147161001544	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1147161001545	TPP-binding site [chemical binding]; other site
1147161001546	manganese transport protein MntH; Reviewed; Region: PRK00701
1147161001547	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1147161001548	Predicted membrane protein [Function unknown]; Region: COG2261
1147161001549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1147161001550	EcsC protein family; Region: EcsC; pfam12787
1147161001551	General stress protein [General function prediction only]; Region: GsiB; COG3729
1147161001552	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1147161001553	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1147161001554	dimanganese center [ion binding]; other site
1147161001555	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1147161001556	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
1147161001557	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1147161001558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161001559	putative active site [active]
1147161001560	heme pocket [chemical binding]; other site
1147161001561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161001562	ATP binding site [chemical binding]; other site
1147161001563	Mg2+ binding site [ion binding]; other site
1147161001564	G-X-G motif; other site
1147161001565	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1147161001566	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161001567	active site
1147161001568	phosphorylation site [posttranslational modification]
1147161001569	intermolecular recognition site; other site
1147161001570	dimerization interface [polypeptide binding]; other site
1147161001571	HTH domain; Region: HTH_11; cl17392
1147161001572	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1147161001573	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1147161001574	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1147161001575	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147161001576	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161001577	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161001578	Walker A/P-loop; other site
1147161001579	ATP binding site [chemical binding]; other site
1147161001580	Q-loop/lid; other site
1147161001581	ABC transporter signature motif; other site
1147161001582	Walker B; other site
1147161001583	D-loop; other site
1147161001584	H-loop/switch region; other site
1147161001585	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1147161001586	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1147161001587	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1147161001588	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1147161001589	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1147161001590	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1147161001591	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1147161001592	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1147161001593	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161001594	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161001595	catalytic residues [active]
1147161001596	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1147161001597	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1147161001598	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1147161001599	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1147161001600	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1147161001601	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147161001602	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147161001603	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1147161001604	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1147161001605	ATP binding site [chemical binding]; other site
1147161001606	Mg++ binding site [ion binding]; other site
1147161001607	motif III; other site
1147161001608	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161001609	nucleotide binding region [chemical binding]; other site
1147161001610	ATP-binding site [chemical binding]; other site
1147161001611	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1147161001612	Predicted membrane protein [Function unknown]; Region: COG3428
1147161001613	Bacterial PH domain; Region: DUF304; pfam03703
1147161001614	Bacterial PH domain; Region: DUF304; pfam03703
1147161001615	Bacterial PH domain; Region: DUF304; pfam03703
1147161001616	Rhomboid family; Region: Rhomboid; pfam01694
1147161001617	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
1147161001618	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1147161001619	alanine racemase; Region: alr; TIGR00492
1147161001620	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1147161001621	active site
1147161001622	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147161001623	dimer interface [polypeptide binding]; other site
1147161001624	substrate binding site [chemical binding]; other site
1147161001625	catalytic residues [active]
1147161001626	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1147161001627	ribbon-helix-helix domain containing protein; Region: PHA00617
1147161001628	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1147161001629	Rsbr N terminal; Region: Rsbr_N; pfam08678
1147161001630	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1147161001631	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1147161001632	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1147161001633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161001634	ATP binding site [chemical binding]; other site
1147161001635	Mg2+ binding site [ion binding]; other site
1147161001636	G-X-G motif; other site
1147161001637	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1147161001638	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1147161001639	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1147161001640	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1147161001641	anti sigma factor interaction site; other site
1147161001642	regulatory phosphorylation site [posttranslational modification]; other site
1147161001643	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1147161001644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161001645	ATP binding site [chemical binding]; other site
1147161001646	Mg2+ binding site [ion binding]; other site
1147161001647	G-X-G motif; other site
1147161001648	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
1147161001649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161001650	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147161001651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161001652	DNA binding residues [nucleotide binding]
1147161001653	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1147161001654	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
1147161001655	hypothetical protein; Provisional; Region: PRK02268
1147161001656	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161001657	MarR family; Region: MarR; pfam01047
1147161001658	MarR family; Region: MarR_2; cl17246
1147161001659	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1147161001660	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1147161001661	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1147161001662	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1147161001663	RNA binding site [nucleotide binding]; other site
1147161001664	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1147161001665	hypothetical protein; Provisional; Region: PRK04351
1147161001666	integrase; Provisional; Region: int; PHA02601
1147161001667	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1147161001668	Int/Topo IB signature motif; other site
1147161001669	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1147161001670	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161001671	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161001672	non-specific DNA binding site [nucleotide binding]; other site
1147161001673	salt bridge; other site
1147161001674	sequence-specific DNA binding site [nucleotide binding]; other site
1147161001675	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1147161001676	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147161001677	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161001678	Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946
1147161001679	Replication initiation factor; Region: Rep_trans; pfam02486
1147161001680	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1147161001681	TcpE family; Region: TcpE; pfam12648
1147161001682	AAA-like domain; Region: AAA_10; pfam12846
1147161001683	Domain of unknown function (DUF1874); Region: DUF1874; pfam08960
1147161001684	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
1147161001685	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1147161001686	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147161001687	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147161001688	catalytic residue [active]
1147161001689	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161001690	Toll - interleukin 1 - resistance; Region: TIR; smart00255
1147161001691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161001692	binding surface
1147161001693	TPR motif; other site
1147161001694	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161001695	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1147161001696	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1147161001697	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1147161001698	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1147161001699	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161001700	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1147161001701	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1147161001702	putative DNA binding site [nucleotide binding]; other site
1147161001703	putative Zn2+ binding site [ion binding]; other site
1147161001704	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161001705	Isochorismatase family; Region: Isochorismatase; pfam00857
1147161001706	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1147161001707	catalytic triad [active]
1147161001708	conserved cis-peptide bond; other site
1147161001709	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1147161001710	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1147161001711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001712	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161001713	putative substrate translocation pore; other site
1147161001714	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1147161001715	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1147161001716	conserved cys residue [active]
1147161001717	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1147161001718	DNA-binding site [nucleotide binding]; DNA binding site
1147161001719	RNA-binding motif; other site
1147161001720	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1147161001721	EamA-like transporter family; Region: EamA; pfam00892
1147161001722	Cupin domain; Region: Cupin_2; pfam07883
1147161001723	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161001724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161001725	EamA-like transporter family; Region: EamA; pfam00892
1147161001726	EamA-like transporter family; Region: EamA; pfam00892
1147161001727	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161001728	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161001729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1147161001730	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161001731	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001732	DNA-binding site [nucleotide binding]; DNA binding site
1147161001733	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161001734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161001735	homodimer interface [polypeptide binding]; other site
1147161001736	catalytic residue [active]
1147161001737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001738	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161001739	putative substrate translocation pore; other site
1147161001740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1147161001741	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1147161001742	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1147161001743	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161001744	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161001745	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001746	DNA-binding site [nucleotide binding]; DNA binding site
1147161001747	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161001748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161001749	homodimer interface [polypeptide binding]; other site
1147161001750	catalytic residue [active]
1147161001751	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1147161001752	putative active site [active]
1147161001753	putative catalytic site [active]
1147161001754	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1147161001755	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1147161001756	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161001757	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161001758	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161001759	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161001760	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161001761	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161001762	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161001763	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161001764	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1147161001765	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147161001766	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161001767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001768	putative substrate translocation pore; other site
1147161001769	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161001770	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161001771	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161001772	dimerization interface [polypeptide binding]; other site
1147161001773	putative DNA binding site [nucleotide binding]; other site
1147161001774	putative Zn2+ binding site [ion binding]; other site
1147161001775	arsenical pump membrane protein; Provisional; Region: PRK15445
1147161001776	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1147161001777	transmembrane helices; other site
1147161001778	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1147161001779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1147161001780	EamA-like transporter family; Region: EamA; pfam00892
1147161001781	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1147161001782	EamA-like transporter family; Region: EamA; pfam00892
1147161001783	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161001784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001785	DNA-binding site [nucleotide binding]; DNA binding site
1147161001786	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161001787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161001788	homodimer interface [polypeptide binding]; other site
1147161001789	catalytic residue [active]
1147161001790	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1147161001791	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161001792	putative DNA binding site [nucleotide binding]; other site
1147161001793	putative Zn2+ binding site [ion binding]; other site
1147161001794	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1147161001795	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1147161001796	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161001797	Histidine kinase; Region: HisKA_3; pfam07730
1147161001798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161001799	ATP binding site [chemical binding]; other site
1147161001800	Mg2+ binding site [ion binding]; other site
1147161001801	G-X-G motif; other site
1147161001802	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161001803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161001804	active site
1147161001805	phosphorylation site [posttranslational modification]
1147161001806	intermolecular recognition site; other site
1147161001807	dimerization interface [polypeptide binding]; other site
1147161001808	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161001809	DNA binding residues [nucleotide binding]
1147161001810	dimerization interface [polypeptide binding]; other site
1147161001811	MMPL family; Region: MMPL; pfam03176
1147161001812	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1147161001813	MMPL family; Region: MMPL; pfam03176
1147161001814	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161001815	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
1147161001816	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1147161001817	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147161001818	DNA binding residues [nucleotide binding]
1147161001819	drug binding residues [chemical binding]; other site
1147161001820	dimer interface [polypeptide binding]; other site
1147161001821	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1147161001822	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1147161001823	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1147161001824	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1147161001825	dimer interface [polypeptide binding]; other site
1147161001826	FMN binding site [chemical binding]; other site
1147161001827	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1147161001828	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161001829	Zn binding site [ion binding]; other site
1147161001830	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1147161001831	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161001832	Zn binding site [ion binding]; other site
1147161001833	Predicted membrane protein [Function unknown]; Region: COG2259
1147161001834	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161001835	catalytic residues [active]
1147161001836	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161001837	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161001838	Predicted membrane protein [Function unknown]; Region: COG2323
1147161001839	Predicted membrane protein [Function unknown]; Region: COG2323
1147161001840	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1147161001841	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1147161001842	putative dimer interface [polypeptide binding]; other site
1147161001843	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161001844	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161001845	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161001846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161001847	DoxX-like family; Region: DoxX_2; pfam13564
1147161001848	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1147161001849	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161001850	Coenzyme A binding pocket [chemical binding]; other site
1147161001851	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147161001852	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161001853	ABC transporter; Region: ABC_tran_2; pfam12848
1147161001854	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161001855	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1147161001856	DinB family; Region: DinB; pfam05163
1147161001857	DinB superfamily; Region: DinB_2; pfam12867
1147161001858	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161001859	MarR family; Region: MarR; pfam01047
1147161001860	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1147161001861	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1147161001862	dimer interface [polypeptide binding]; other site
1147161001863	FMN binding site [chemical binding]; other site
1147161001864	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161001865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161001866	putative DNA binding site [nucleotide binding]; other site
1147161001867	putative Zn2+ binding site [ion binding]; other site
1147161001868	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1147161001869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001870	putative substrate translocation pore; other site
1147161001871	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1147161001872	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1147161001873	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001874	DNA-binding site [nucleotide binding]; DNA binding site
1147161001875	FCD domain; Region: FCD; pfam07729
1147161001876	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1147161001877	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161001878	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161001879	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1147161001880	active site
1147161001881	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1147161001882	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1147161001883	homodimer interface [polypeptide binding]; other site
1147161001884	active site
1147161001885	TDP-binding site; other site
1147161001886	acceptor substrate-binding pocket; other site
1147161001887	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1147161001888	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1147161001889	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1147161001890	dimer interface [polypeptide binding]; other site
1147161001891	active site
1147161001892	Uncharacterized conserved protein [Function unknown]; Region: COG5646
1147161001893	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161001894	Coenzyme A binding pocket [chemical binding]; other site
1147161001895	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1147161001896	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161001897	Zn2+ binding site [ion binding]; other site
1147161001898	Mg2+ binding site [ion binding]; other site
1147161001899	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1147161001900	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1147161001901	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161001902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001903	putative substrate translocation pore; other site
1147161001904	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1147161001905	active site
1147161001906	P-loop; other site
1147161001907	phosphorylation site [posttranslational modification]
1147161001908	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1147161001909	active site
1147161001910	methionine cluster; other site
1147161001911	phosphorylation site [posttranslational modification]
1147161001912	metal binding site [ion binding]; metal-binding site
1147161001913	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1147161001914	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
1147161001915	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1147161001916	beta-galactosidase; Region: BGL; TIGR03356
1147161001917	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147161001918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161001919	DNA-binding site [nucleotide binding]; DNA binding site
1147161001920	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1147161001921	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1147161001922	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161001923	nucleotide binding site [chemical binding]; other site
1147161001924	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1147161001925	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1147161001926	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1147161001927	thiamine-monophosphate kinase; Region: thiL; TIGR01379
1147161001928	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1147161001929	ATP binding site [chemical binding]; other site
1147161001930	dimerization interface [polypeptide binding]; other site
1147161001931	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1147161001932	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1147161001933	Glycoprotease family; Region: Peptidase_M22; pfam00814
1147161001934	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1147161001935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161001936	Coenzyme A binding pocket [chemical binding]; other site
1147161001937	UGMP family protein; Validated; Region: PRK09604
1147161001938	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161001939	nucleotide binding site [chemical binding]; other site
1147161001940	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147161001941	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161001942	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161001943	ABC transporter; Region: ABC_tran_2; pfam12848
1147161001944	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161001945	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1147161001946	trimer interface [polypeptide binding]; other site
1147161001947	dimer interface [polypeptide binding]; other site
1147161001948	putative active site [active]
1147161001949	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1147161001950	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1147161001951	CoA binding domain; Region: CoA_binding; pfam02629
1147161001952	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1147161001953	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
1147161001954	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
1147161001955	CAAX protease self-immunity; Region: Abi; pfam02517
1147161001956	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1147161001957	oligomerisation interface [polypeptide binding]; other site
1147161001958	mobile loop; other site
1147161001959	roof hairpin; other site
1147161001960	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1147161001961	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1147161001962	ring oligomerisation interface [polypeptide binding]; other site
1147161001963	ATP/Mg binding site [chemical binding]; other site
1147161001964	stacking interactions; other site
1147161001965	hinge regions; other site
1147161001966	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1147161001967	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147161001968	cofactor binding site; other site
1147161001969	DNA binding site [nucleotide binding]
1147161001970	substrate interaction site [chemical binding]; other site
1147161001971	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1147161001972	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147161001973	cofactor binding site; other site
1147161001974	DNA binding site [nucleotide binding]
1147161001975	substrate interaction site [chemical binding]; other site
1147161001976	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
1147161001977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1147161001978	LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563
1147161001979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1147161001980	Walker A motif; other site
1147161001981	ATP binding site [chemical binding]; other site
1147161001982	Walker B motif; other site
1147161001983	TPR repeat; Region: TPR_11; pfam13414
1147161001984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161001985	TPR motif; other site
1147161001986	TPR repeat; Region: TPR_11; pfam13414
1147161001987	binding surface
1147161001988	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1147161001989	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1147161001990	inhibitor binding site; inhibition site
1147161001991	catalytic Zn binding site [ion binding]; other site
1147161001992	structural Zn binding site [ion binding]; other site
1147161001993	NADP binding site [chemical binding]; other site
1147161001994	tetramer interface [polypeptide binding]; other site
1147161001995	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1147161001996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161001997	putative substrate translocation pore; other site
1147161001998	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1147161001999	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1147161002000	putative substrate binding site [chemical binding]; other site
1147161002001	putative ATP binding site [chemical binding]; other site
1147161002002	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1147161002003	TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
1147161002004	DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981
1147161002005	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1147161002006	Repair protein; Region: Repair_PSII; pfam04536
1147161002007	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
1147161002008	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
1147161002009	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1147161002010	Double zinc ribbon; Region: DZR; pfam12773
1147161002011	Ion channel; Region: Ion_trans_2; pfam07885
1147161002012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002013	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1147161002014	putative substrate translocation pore; other site
1147161002015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002016	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1147161002017	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1147161002018	putative NAD(P) binding site [chemical binding]; other site
1147161002019	catalytic Zn binding site [ion binding]; other site
1147161002020	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1147161002021	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1147161002022	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161002023	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147161002024	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
1147161002025	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1147161002026	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1147161002027	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1147161002028	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1147161002029	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1147161002030	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1147161002031	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1147161002032	MoxR-like ATPases [General function prediction only]; Region: COG0714
1147161002033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161002034	Walker A motif; other site
1147161002035	ATP binding site [chemical binding]; other site
1147161002036	Walker B motif; other site
1147161002037	arginine finger; other site
1147161002038	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1147161002039	Protein of unknown function DUF58; Region: DUF58; pfam01882
1147161002040	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1147161002041	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1147161002042	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1147161002043	GMP synthase; Reviewed; Region: guaA; PRK00074
1147161002044	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1147161002045	AMP/PPi binding site [chemical binding]; other site
1147161002046	candidate oxyanion hole; other site
1147161002047	catalytic triad [active]
1147161002048	potential glutamine specificity residues [chemical binding]; other site
1147161002049	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1147161002050	ATP Binding subdomain [chemical binding]; other site
1147161002051	Ligand Binding sites [chemical binding]; other site
1147161002052	Dimerization subdomain; other site
1147161002053	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1147161002054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1147161002055	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161002056	NETI protein; Region: NETI; pfam14044
1147161002057	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1147161002058	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1147161002059	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1147161002060	NAD binding site [chemical binding]; other site
1147161002061	ATP-grasp domain; Region: ATP-grasp; pfam02222
1147161002062	adenylosuccinate lyase; Provisional; Region: PRK07492
1147161002063	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1147161002064	tetramer interface [polypeptide binding]; other site
1147161002065	active site
1147161002066	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1147161002067	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1147161002068	ATP binding site [chemical binding]; other site
1147161002069	active site
1147161002070	substrate binding site [chemical binding]; other site
1147161002071	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1147161002072	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1147161002073	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1147161002074	putative active site [active]
1147161002075	catalytic triad [active]
1147161002076	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1147161002077	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1147161002078	dimerization interface [polypeptide binding]; other site
1147161002079	ATP binding site [chemical binding]; other site
1147161002080	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1147161002081	dimerization interface [polypeptide binding]; other site
1147161002082	ATP binding site [chemical binding]; other site
1147161002083	amidophosphoribosyltransferase; Provisional; Region: PRK07631
1147161002084	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1147161002085	active site
1147161002086	tetramer interface [polypeptide binding]; other site
1147161002087	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161002088	active site
1147161002089	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1147161002090	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1147161002091	dimerization interface [polypeptide binding]; other site
1147161002092	putative ATP binding site [chemical binding]; other site
1147161002093	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1147161002094	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1147161002095	active site
1147161002096	substrate binding site [chemical binding]; other site
1147161002097	cosubstrate binding site; other site
1147161002098	catalytic site [active]
1147161002099	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1147161002100	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1147161002101	purine monophosphate binding site [chemical binding]; other site
1147161002102	dimer interface [polypeptide binding]; other site
1147161002103	putative catalytic residues [active]
1147161002104	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1147161002105	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1147161002106	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1147161002107	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1147161002108	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1147161002109	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1147161002110	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1147161002111	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161002112	putative DNA binding site [nucleotide binding]; other site
1147161002113	putative Zn2+ binding site [ion binding]; other site
1147161002114	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161002115	putative transporter; Provisional; Region: PRK11021
1147161002116	Spore germination protein; Region: Spore_permease; cl17796
1147161002117	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1147161002118	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1147161002119	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147161002120	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1147161002121	active site
1147161002122	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147161002123	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
1147161002124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
1147161002125	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1147161002126	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1147161002127	active site
1147161002128	FMN binding site [chemical binding]; other site
1147161002129	substrate binding site [chemical binding]; other site
1147161002130	3Fe-4S cluster binding site [ion binding]; other site
1147161002131	PcrB family; Region: PcrB; pfam01884
1147161002132	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1147161002133	substrate binding site [chemical binding]; other site
1147161002134	putative active site [active]
1147161002135	dimer interface [polypeptide binding]; other site
1147161002136	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1147161002137	Part of AAA domain; Region: AAA_19; pfam13245
1147161002138	Family description; Region: UvrD_C_2; pfam13538
1147161002139	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1147161002140	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1147161002141	nucleotide binding pocket [chemical binding]; other site
1147161002142	K-X-D-G motif; other site
1147161002143	catalytic site [active]
1147161002144	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1147161002145	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1147161002146	Helix-hairpin-helix motif; Region: HHH; pfam00633
1147161002147	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1147161002148	Dimer interface [polypeptide binding]; other site
1147161002149	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1147161002150	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1147161002151	putative dimer interface [polypeptide binding]; other site
1147161002152	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1147161002153	putative dimer interface [polypeptide binding]; other site
1147161002154	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1147161002155	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1147161002156	active site
1147161002157	ATP binding site [chemical binding]; other site
1147161002158	substrate binding site [chemical binding]; other site
1147161002159	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1147161002160	MgtC family; Region: MgtC; pfam02308
1147161002161	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1147161002162	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1147161002163	Na binding site [ion binding]; other site
1147161002164	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1147161002165	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1147161002166	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1147161002167	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1147161002168	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1147161002169	GatB domain; Region: GatB_Yqey; pfam02637
1147161002170	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161002171	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161002172	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1147161002173	Protein export membrane protein; Region: SecD_SecF; cl14618
1147161002174	Protein export membrane protein; Region: SecD_SecF; cl14618
1147161002175	putative lipid kinase; Reviewed; Region: PRK13337
1147161002176	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1147161002177	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1147161002178	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1147161002179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161002180	S-adenosylmethionine binding site [chemical binding]; other site
1147161002181	Recombinase; Region: Recombinase; pfam07508
1147161002182	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1147161002183	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147161002184	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1147161002185	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1147161002186	DNA-binding interface [nucleotide binding]; DNA binding site
1147161002187	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1147161002188	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1147161002189	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1147161002190	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161002191	ATP binding site [chemical binding]; other site
1147161002192	putative Mg++ binding site [ion binding]; other site
1147161002193	T5orf172 domain; Region: T5orf172; pfam10544
1147161002194	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
1147161002195	Protein of unknown function, DUF600; Region: DUF600; cl04640
1147161002196	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1147161002197	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1147161002198	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161002199	hypothetical protein; Provisional; Region: PRK12378
1147161002200	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161002201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161002202	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1147161002203	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1147161002204	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1147161002205	NADP binding site [chemical binding]; other site
1147161002206	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1147161002207	CotJB protein; Region: CotJB; pfam12652
1147161002208	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1147161002209	dimanganese center [ion binding]; other site
1147161002210	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161002211	Coenzyme A binding pocket [chemical binding]; other site
1147161002212	YesK-like protein; Region: YesK; pfam14150
1147161002213	Predicted integral membrane protein [Function unknown]; Region: COG5578
1147161002214	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1147161002215	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1147161002216	dimerization interface [polypeptide binding]; other site
1147161002217	Histidine kinase; Region: His_kinase; pfam06580
1147161002218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161002219	ATP binding site [chemical binding]; other site
1147161002220	Mg2+ binding site [ion binding]; other site
1147161002221	G-X-G motif; other site
1147161002222	Response regulator receiver domain; Region: Response_reg; pfam00072
1147161002223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161002224	active site
1147161002225	phosphorylation site [posttranslational modification]
1147161002226	intermolecular recognition site; other site
1147161002227	dimerization interface [polypeptide binding]; other site
1147161002228	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161002229	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161002230	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147161002231	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161002232	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1147161002233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161002234	dimer interface [polypeptide binding]; other site
1147161002235	conserved gate region; other site
1147161002236	putative PBP binding loops; other site
1147161002237	ABC-ATPase subunit interface; other site
1147161002238	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161002239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161002240	dimer interface [polypeptide binding]; other site
1147161002241	conserved gate region; other site
1147161002242	putative PBP binding loops; other site
1147161002243	ABC-ATPase subunit interface; other site
1147161002244	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1147161002245	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161002246	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161002247	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1147161002248	active site
1147161002249	catalytic triad [active]
1147161002250	Domain of unknown function (DUF1961); Region: DUF1961; pfam09224
1147161002251	Predicted integral membrane protein [Function unknown]; Region: COG5578
1147161002252	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1147161002253	metal binding site [ion binding]; metal-binding site
1147161002254	active site
1147161002255	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1147161002256	metal binding site [ion binding]; metal-binding site
1147161002257	active site
1147161002258	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1147161002259	active site
1147161002260	catalytic triad [active]
1147161002261	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1147161002262	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1147161002263	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1147161002264	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1147161002265	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147161002266	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161002267	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1147161002268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161002269	dimer interface [polypeptide binding]; other site
1147161002270	putative PBP binding loops; other site
1147161002271	ABC-ATPase subunit interface; other site
1147161002272	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161002273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161002274	dimer interface [polypeptide binding]; other site
1147161002275	conserved gate region; other site
1147161002276	putative PBP binding loops; other site
1147161002277	ABC-ATPase subunit interface; other site
1147161002278	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1147161002279	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1147161002280	NAD binding site [chemical binding]; other site
1147161002281	sugar binding site [chemical binding]; other site
1147161002282	divalent metal binding site [ion binding]; other site
1147161002283	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161002284	dimer interface [polypeptide binding]; other site
1147161002285	Predicted membrane protein [Function unknown]; Region: COG2323
1147161002286	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1147161002287	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161002288	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1147161002289	Uncharacterized small protein [Function unknown]; Region: COG5583
1147161002290	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1147161002291	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1147161002292	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161002293	EamA-like transporter family; Region: EamA; pfam00892
1147161002294	EamA-like transporter family; Region: EamA; pfam00892
1147161002295	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161002296	MarR family; Region: MarR; pfam01047
1147161002297	hypothetical protein; Provisional; Region: PRK06847
1147161002298	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1147161002299	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
1147161002300	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
1147161002301	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161002302	Cytochrome P450; Region: p450; pfam00067
1147161002303	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1147161002304	Flavodoxin; Region: Flavodoxin_1; pfam00258
1147161002305	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1147161002306	FAD binding pocket [chemical binding]; other site
1147161002307	FAD binding motif [chemical binding]; other site
1147161002308	catalytic residues [active]
1147161002309	NAD binding pocket [chemical binding]; other site
1147161002310	phosphate binding motif [ion binding]; other site
1147161002311	beta-alpha-beta structure motif; other site
1147161002312	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1147161002313	Sulfatase; Region: Sulfatase; pfam00884
1147161002314	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1147161002315	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1147161002316	substrate binding site; other site
1147161002317	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1147161002318	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161002319	NAD(P) binding site [chemical binding]; other site
1147161002320	active site
1147161002321	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
1147161002322	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161002323	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161002324	active site
1147161002325	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147161002326	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
1147161002327	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161002328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002329	putative substrate translocation pore; other site
1147161002330	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1147161002331	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161002332	active site
1147161002333	motif I; other site
1147161002334	motif II; other site
1147161002335	amino acid transporter; Region: 2A0306; TIGR00909
1147161002336	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1147161002337	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
1147161002338	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1147161002339	NAD(P) binding site [chemical binding]; other site
1147161002340	catalytic residues [active]
1147161002341	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1147161002342	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161002343	dimer interface [polypeptide binding]; other site
1147161002344	putative CheW interface [polypeptide binding]; other site
1147161002345	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147161002346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161002347	Walker A/P-loop; other site
1147161002348	ATP binding site [chemical binding]; other site
1147161002349	Q-loop/lid; other site
1147161002350	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161002351	ABC transporter signature motif; other site
1147161002352	Walker B; other site
1147161002353	D-loop; other site
1147161002354	ABC transporter; Region: ABC_tran_2; pfam12848
1147161002355	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161002356	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
1147161002357	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147161002358	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
1147161002359	DNA binding residues [nucleotide binding]
1147161002360	putative dimer interface [polypeptide binding]; other site
1147161002361	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161002362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002363	putative substrate translocation pore; other site
1147161002364	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147161002365	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161002366	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161002367	ABC transporter; Region: ABC_tran_2; pfam12848
1147161002368	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161002369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1147161002370	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1147161002371	ATP binding site [chemical binding]; other site
1147161002372	putative Mg++ binding site [ion binding]; other site
1147161002373	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161002374	nucleotide binding region [chemical binding]; other site
1147161002375	ATP-binding site [chemical binding]; other site
1147161002376	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1147161002377	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147161002378	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1147161002379	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1147161002380	NAD(P) binding site [chemical binding]; other site
1147161002381	substrate binding site [chemical binding]; other site
1147161002382	dimer interface [polypeptide binding]; other site
1147161002383	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147161002384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002385	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1147161002386	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1147161002387	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147161002388	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1147161002389	Walker A/P-loop; other site
1147161002390	ATP binding site [chemical binding]; other site
1147161002391	Q-loop/lid; other site
1147161002392	ABC transporter signature motif; other site
1147161002393	Walker B; other site
1147161002394	D-loop; other site
1147161002395	H-loop/switch region; other site
1147161002396	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1147161002397	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161002398	ABC-ATPase subunit  interface; other site
1147161002399	dimer interface [polypeptide binding]; other site
1147161002400	putative PBP binding regions; other site
1147161002401	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1147161002402	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161002403	ABC-ATPase subunit  interface; other site
1147161002404	dimer interface [polypeptide binding]; other site
1147161002405	putative PBP binding regions; other site
1147161002406	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1147161002407	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1147161002408	siderophore binding site; other site
1147161002409	Protein of unknown function (DUF3212); Region: DUF3212; pfam11486
1147161002410	Heat induced stress protein YflT; Region: YflT; pfam11181
1147161002411	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1147161002412	Amb_all domain; Region: Amb_all; smart00656
1147161002413	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1147161002414	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1147161002415	transmembrane helices; other site
1147161002416	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1147161002417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161002418	ATP binding site [chemical binding]; other site
1147161002419	Mg2+ binding site [ion binding]; other site
1147161002420	G-X-G motif; other site
1147161002421	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1147161002422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161002423	active site
1147161002424	phosphorylation site [posttranslational modification]
1147161002425	intermolecular recognition site; other site
1147161002426	dimerization interface [polypeptide binding]; other site
1147161002427	Transcriptional regulator; Region: CitT; pfam12431
1147161002428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1147161002429	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
1147161002430	Citrate transporter; Region: CitMHS; pfam03600
1147161002431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161002432	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1147161002433	active site
1147161002434	dimer interface [polypeptide binding]; other site
1147161002435	acylphosphatase; Provisional; Region: PRK14420
1147161002436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1147161002437	MOSC domain; Region: MOSC; pfam03473
1147161002438	3-alpha domain; Region: 3-alpha; pfam03475
1147161002439	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
1147161002440	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1147161002441	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1147161002442	active site
1147161002443	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1147161002444	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161002445	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161002446	active site turn [active]
1147161002447	phosphorylation site [posttranslational modification]
1147161002448	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1147161002449	Sulfatase; Region: Sulfatase; pfam00884
1147161002450	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1147161002451	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1147161002452	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1147161002453	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
1147161002454	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147161002455	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147161002456	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147161002457	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1147161002458	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161002459	active site turn [active]
1147161002460	phosphorylation site [posttranslational modification]
1147161002461	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161002462	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1147161002463	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1147161002464	Ca binding site [ion binding]; other site
1147161002465	active site
1147161002466	catalytic site [active]
1147161002467	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1147161002468	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161002469	DNA-binding site [nucleotide binding]; DNA binding site
1147161002470	UTRA domain; Region: UTRA; pfam07702
1147161002471	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1147161002472	dimer interface [polypeptide binding]; other site
1147161002473	FMN binding site [chemical binding]; other site
1147161002474	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
1147161002475	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1147161002476	active site
1147161002477	metal binding site [ion binding]; metal-binding site
1147161002478	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1147161002479	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
1147161002480	active site
1147161002481	metal binding site [ion binding]; metal-binding site
1147161002482	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1147161002483	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1147161002484	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1147161002485	proposed catalytic triad [active]
1147161002486	conserved cys residue [active]
1147161002487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002488	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161002489	putative substrate translocation pore; other site
1147161002490	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
1147161002491	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1147161002492	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1147161002493	active site
1147161002494	YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
1147161002495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002496	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161002497	putative substrate translocation pore; other site
1147161002498	calcium/proton exchanger (cax); Region: cax; TIGR00378
1147161002499	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1147161002500	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1147161002501	YfkD-like protein; Region: YfkD; pfam14167
1147161002502	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1147161002503	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1147161002504	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1147161002505	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161002506	FeS/SAM binding site; other site
1147161002507	YfkB-like domain; Region: YfkB; pfam08756
1147161002508	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1147161002509	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1147161002510	NodB motif; other site
1147161002511	active site
1147161002512	catalytic site [active]
1147161002513	Cd binding site [ion binding]; other site
1147161002514	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1147161002515	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1147161002516	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1147161002517	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1147161002518	oligomer interface [polypeptide binding]; other site
1147161002519	metal binding site [ion binding]; metal-binding site
1147161002520	metal binding site [ion binding]; metal-binding site
1147161002521	putative Cl binding site [ion binding]; other site
1147161002522	aspartate ring; other site
1147161002523	basic sphincter; other site
1147161002524	hydrophobic gate; other site
1147161002525	periplasmic entrance; other site
1147161002526	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1147161002527	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1147161002528	minor groove reading motif; other site
1147161002529	helix-hairpin-helix signature motif; other site
1147161002530	substrate binding pocket [chemical binding]; other site
1147161002531	active site
1147161002532	TRAM domain; Region: TRAM; pfam01938
1147161002533	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1147161002534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161002535	S-adenosylmethionine binding site [chemical binding]; other site
1147161002536	YfzA-like protein; Region: YfzA; pfam14118
1147161002537	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1147161002538	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1147161002539	FMN binding site [chemical binding]; other site
1147161002540	active site
1147161002541	catalytic residues [active]
1147161002542	substrate binding site [chemical binding]; other site
1147161002543	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
1147161002544	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1147161002545	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1147161002546	tetramer interface [polypeptide binding]; other site
1147161002547	TPP-binding site [chemical binding]; other site
1147161002548	heterodimer interface [polypeptide binding]; other site
1147161002549	phosphorylation loop region [posttranslational modification]
1147161002550	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1147161002551	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1147161002552	alpha subunit interface [polypeptide binding]; other site
1147161002553	TPP binding site [chemical binding]; other site
1147161002554	heterodimer interface [polypeptide binding]; other site
1147161002555	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147161002556	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1147161002557	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1147161002558	E3 interaction surface; other site
1147161002559	lipoyl attachment site [posttranslational modification]; other site
1147161002560	e3 binding domain; Region: E3_binding; pfam02817
1147161002561	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1147161002562	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
1147161002563	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161002564	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1147161002565	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1147161002566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161002567	Walker A motif; other site
1147161002568	ATP binding site [chemical binding]; other site
1147161002569	Walker B motif; other site
1147161002570	arginine finger; other site
1147161002571	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1147161002572	acid-soluble spore protein H; Provisional; Region: sspH; PRK03174
1147161002573	hypothetical protein; Provisional; Region: PRK02237
1147161002574	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1147161002575	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1147161002576	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1147161002577	NAD binding site [chemical binding]; other site
1147161002578	sugar binding site [chemical binding]; other site
1147161002579	divalent metal binding site [ion binding]; other site
1147161002580	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161002581	dimer interface [polypeptide binding]; other site
1147161002582	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1147161002583	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1147161002584	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1147161002585	putative active site [active]
1147161002586	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1147161002587	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1147161002588	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161002589	active site turn [active]
1147161002590	phosphorylation site [posttranslational modification]
1147161002591	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161002592	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161002593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161002594	Walker A/P-loop; other site
1147161002595	ATP binding site [chemical binding]; other site
1147161002596	Q-loop/lid; other site
1147161002597	ABC transporter signature motif; other site
1147161002598	Walker B; other site
1147161002599	D-loop; other site
1147161002600	H-loop/switch region; other site
1147161002601	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161002602	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161002603	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1147161002604	Walker A/P-loop; other site
1147161002605	ATP binding site [chemical binding]; other site
1147161002606	Q-loop/lid; other site
1147161002607	ABC transporter signature motif; other site
1147161002608	Walker B; other site
1147161002609	D-loop; other site
1147161002610	H-loop/switch region; other site
1147161002611	Predicted membrane protein [Function unknown]; Region: COG2259
1147161002612	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1147161002613	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1147161002614	putative metal binding site [ion binding]; other site
1147161002615	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1147161002616	active site
1147161002617	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1147161002618	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1147161002619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161002620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161002621	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1147161002622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002623	putative substrate translocation pore; other site
1147161002624	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1147161002625	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1147161002626	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161002627	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161002628	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161002629	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161002630	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1147161002631	Histidine kinase; Region: HisKA_3; pfam07730
1147161002632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161002633	ATP binding site [chemical binding]; other site
1147161002634	Mg2+ binding site [ion binding]; other site
1147161002635	G-X-G motif; other site
1147161002636	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161002637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161002638	active site
1147161002639	phosphorylation site [posttranslational modification]
1147161002640	intermolecular recognition site; other site
1147161002641	dimerization interface [polypeptide binding]; other site
1147161002642	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161002643	DNA binding residues [nucleotide binding]
1147161002644	dimerization interface [polypeptide binding]; other site
1147161002645	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161002646	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161002647	Walker A/P-loop; other site
1147161002648	ATP binding site [chemical binding]; other site
1147161002649	Q-loop/lid; other site
1147161002650	ABC transporter signature motif; other site
1147161002651	Walker B; other site
1147161002652	D-loop; other site
1147161002653	H-loop/switch region; other site
1147161002654	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1147161002655	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1147161002656	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1147161002657	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1147161002658	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1147161002659	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1147161002660	Predicted transcriptional regulators [Transcription]; Region: COG1695
1147161002661	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1147161002662	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1147161002663	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1147161002664	Lipase (class 2); Region: Lipase_2; pfam01674
1147161002665	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1147161002666	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1147161002667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161002668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161002669	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147161002670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002671	putative substrate translocation pore; other site
1147161002672	metal-dependent hydrolase; Provisional; Region: PRK13291
1147161002673	DinB superfamily; Region: DinB_2; pfam12867
1147161002674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002675	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161002676	putative substrate translocation pore; other site
1147161002677	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161002678	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161002679	putative Zn2+ binding site [ion binding]; other site
1147161002680	putative DNA binding site [nucleotide binding]; other site
1147161002681	Predicted integral membrane protein [Function unknown]; Region: COG0392
1147161002682	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1147161002683	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1147161002684	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1147161002685	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1147161002686	siderophore binding site; other site
1147161002687	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1147161002688	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161002689	ABC-ATPase subunit  interface; other site
1147161002690	dimer interface [polypeptide binding]; other site
1147161002691	putative PBP binding regions; other site
1147161002692	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1147161002693	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161002694	ABC-ATPase subunit  interface; other site
1147161002695	dimer interface [polypeptide binding]; other site
1147161002696	putative PBP binding regions; other site
1147161002697	phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654
1147161002698	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1147161002699	putative FMN binding site [chemical binding]; other site
1147161002700	YfhD-like protein; Region: YfhD; pfam14151
1147161002701	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1147161002702	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1147161002703	putative NAD(P) binding site [chemical binding]; other site
1147161002704	putative active site [active]
1147161002705	recombination regulator RecX; Provisional; Region: recX; PRK14135
1147161002706	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1147161002707	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161002708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002709	putative substrate translocation pore; other site
1147161002710	Small acid-soluble spore protein K family; Region: SspK; pfam08176
1147161002711	WVELL protein; Region: WVELL; pfam14043
1147161002712	Bacterial SH3 domain; Region: SH3_3; pfam08239
1147161002713	Bacterial SH3 domain; Region: SH3_3; cl17532
1147161002714	Predicted integral membrane protein [Function unknown]; Region: COG5658
1147161002715	SdpI/YhfL protein family; Region: SdpI; pfam13630
1147161002716	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161002717	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147161002718	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1147161002719	catalytic site [active]
1147161002720	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1147161002721	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1147161002722	Ligand binding site; other site
1147161002723	Putative Catalytic site; other site
1147161002724	DXD motif; other site
1147161002725	Predicted membrane protein [Function unknown]; Region: COG4485
1147161002726	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1147161002727	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
1147161002728	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1147161002729	minor groove reading motif; other site
1147161002730	helix-hairpin-helix signature motif; other site
1147161002731	substrate binding pocket [chemical binding]; other site
1147161002732	active site
1147161002733	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1147161002734	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1147161002735	DNA binding and oxoG recognition site [nucleotide binding]
1147161002736	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
1147161002737	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
1147161002738	putative NAD(P) binding site [chemical binding]; other site
1147161002739	active site
1147161002740	YgaB-like protein; Region: YgaB; pfam14182
1147161002741	hypothetical protein; Provisional; Region: PRK13662
1147161002742	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161002743	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161002744	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1147161002745	Walker A/P-loop; other site
1147161002746	ATP binding site [chemical binding]; other site
1147161002747	Q-loop/lid; other site
1147161002748	ABC transporter signature motif; other site
1147161002749	Walker B; other site
1147161002750	D-loop; other site
1147161002751	H-loop/switch region; other site
1147161002752	Predicted membrane protein [Function unknown]; Region: COG4129
1147161002753	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1147161002754	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1147161002755	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161002756	inhibitor-cofactor binding pocket; inhibition site
1147161002757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161002758	catalytic residue [active]
1147161002759	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1147161002760	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1147161002761	catalytic triad [active]
1147161002762	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1147161002763	metal binding site 2 [ion binding]; metal-binding site
1147161002764	putative DNA binding helix; other site
1147161002765	metal binding site 1 [ion binding]; metal-binding site
1147161002766	dimer interface [polypeptide binding]; other site
1147161002767	structural Zn2+ binding site [ion binding]; other site
1147161002768	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
1147161002769	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1147161002770	SpoOM protein; Region: Spo0M; pfam07070
1147161002771	Coat F domain; Region: Coat_F; pfam07875
1147161002772	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1147161002773	active site pocket [active]
1147161002774	oxyanion hole [active]
1147161002775	catalytic triad [active]
1147161002776	active site nucleophile [active]
1147161002777	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1147161002778	ThiC-associated domain; Region: ThiC-associated; pfam13667
1147161002779	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1147161002780	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1147161002781	FAD binding domain; Region: FAD_binding_4; pfam01565
1147161002782	Berberine and berberine like; Region: BBE; pfam08031
1147161002783	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1147161002784	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1147161002785	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1147161002786	tetramer interface [polypeptide binding]; other site
1147161002787	heme binding pocket [chemical binding]; other site
1147161002788	NADPH binding site [chemical binding]; other site
1147161002789	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1147161002790	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1147161002791	Walker A/P-loop; other site
1147161002792	ATP binding site [chemical binding]; other site
1147161002793	Q-loop/lid; other site
1147161002794	ABC transporter signature motif; other site
1147161002795	Walker B; other site
1147161002796	D-loop; other site
1147161002797	H-loop/switch region; other site
1147161002798	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1147161002799	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161002800	substrate binding pocket [chemical binding]; other site
1147161002801	membrane-bound complex binding site; other site
1147161002802	hinge residues; other site
1147161002803	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1147161002804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161002805	dimer interface [polypeptide binding]; other site
1147161002806	conserved gate region; other site
1147161002807	putative PBP binding loops; other site
1147161002808	ABC-ATPase subunit interface; other site
1147161002809	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1147161002810	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1147161002811	active site
1147161002812	dimer interface [polypeptide binding]; other site
1147161002813	non-prolyl cis peptide bond; other site
1147161002814	insertion regions; other site
1147161002815	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1147161002816	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161002817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161002818	non-specific DNA binding site [nucleotide binding]; other site
1147161002819	salt bridge; other site
1147161002820	sequence-specific DNA binding site [nucleotide binding]; other site
1147161002821	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1147161002822	epoxyqueuosine reductase; Region: TIGR00276
1147161002823	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1147161002824	Putative amidase domain; Region: Amidase_6; pfam12671
1147161002825	tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185
1147161002826	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
1147161002827	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1147161002828	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1147161002829	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1147161002830	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1147161002831	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1147161002832	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
1147161002833	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161002834	MarR family; Region: MarR; pfam01047
1147161002835	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1147161002836	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147161002837	carboxyltransferase (CT) interaction site; other site
1147161002838	biotinylation site [posttranslational modification]; other site
1147161002839	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147161002840	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1147161002841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002842	putative substrate translocation pore; other site
1147161002843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161002844	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1147161002845	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147161002846	Predicted transcriptional regulators [Transcription]; Region: COG1725
1147161002847	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161002848	DNA-binding site [nucleotide binding]; DNA binding site
1147161002849	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1147161002850	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161002851	Walker A/P-loop; other site
1147161002852	ATP binding site [chemical binding]; other site
1147161002853	Q-loop/lid; other site
1147161002854	ABC transporter signature motif; other site
1147161002855	Walker B; other site
1147161002856	D-loop; other site
1147161002857	H-loop/switch region; other site
1147161002858	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161002859	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161002860	Walker A/P-loop; other site
1147161002861	ATP binding site [chemical binding]; other site
1147161002862	Q-loop/lid; other site
1147161002863	ABC transporter signature motif; other site
1147161002864	Walker B; other site
1147161002865	D-loop; other site
1147161002866	H-loop/switch region; other site
1147161002867	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1147161002868	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1147161002869	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1147161002870	DNA-binding site [nucleotide binding]; DNA binding site
1147161002871	RNA-binding motif; other site
1147161002872	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1147161002873	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1147161002874	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1147161002875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147161002876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147161002877	metal binding site [ion binding]; metal-binding site
1147161002878	active site
1147161002879	I-site; other site
1147161002880	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1147161002881	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1147161002882	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1147161002883	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1147161002884	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1147161002885	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1147161002886	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1147161002887	generic binding surface II; other site
1147161002888	generic binding surface I; other site
1147161002889	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1147161002890	generic binding surface II; other site
1147161002891	generic binding surface I; other site
1147161002892	Staphylococcal nuclease homologues; Region: SNc; smart00318
1147161002893	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1147161002894	Catalytic site; other site
1147161002895	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1147161002896	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1147161002897	putative active site [active]
1147161002898	putative metal binding site [ion binding]; other site
1147161002899	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1147161002900	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1147161002901	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
1147161002902	active site
1147161002903	catalytic site [active]
1147161002904	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1147161002905	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161002906	RNA binding surface [nucleotide binding]; other site
1147161002907	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147161002908	active site
1147161002909	FOG: CBS domain [General function prediction only]; Region: COG0517
1147161002910	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1147161002911	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1147161002912	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161002913	motif II; other site
1147161002914	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161002915	Coenzyme A binding pocket [chemical binding]; other site
1147161002916	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1147161002917	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1147161002918	putative active site [active]
1147161002919	catalytic triad [active]
1147161002920	putative dimer interface [polypeptide binding]; other site
1147161002921	aminotransferase; Validated; Region: PRK07678
1147161002922	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161002923	inhibitor-cofactor binding pocket; inhibition site
1147161002924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161002925	catalytic residue [active]
1147161002926	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
1147161002927	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1147161002928	amphipathic channel; other site
1147161002929	Asn-Pro-Ala signature motifs; other site
1147161002930	glycerol kinase; Provisional; Region: glpK; PRK00047
1147161002931	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1147161002932	N- and C-terminal domain interface [polypeptide binding]; other site
1147161002933	active site
1147161002934	MgATP binding site [chemical binding]; other site
1147161002935	catalytic site [active]
1147161002936	metal binding site [ion binding]; metal-binding site
1147161002937	glycerol binding site [chemical binding]; other site
1147161002938	homotetramer interface [polypeptide binding]; other site
1147161002939	homodimer interface [polypeptide binding]; other site
1147161002940	FBP binding site [chemical binding]; other site
1147161002941	protein IIAGlc interface [polypeptide binding]; other site
1147161002942	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1147161002943	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1147161002944	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1147161002945	active site
1147161002946	substrate binding site [chemical binding]; other site
1147161002947	metal binding site [ion binding]; metal-binding site
1147161002948	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1147161002949	GAF domain; Region: GAF; pfam01590
1147161002950	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161002951	Histidine kinase; Region: HisKA_3; pfam07730
1147161002952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161002953	ATP binding site [chemical binding]; other site
1147161002954	Mg2+ binding site [ion binding]; other site
1147161002955	G-X-G motif; other site
1147161002956	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161002957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161002958	active site
1147161002959	phosphorylation site [posttranslational modification]
1147161002960	intermolecular recognition site; other site
1147161002961	dimerization interface [polypeptide binding]; other site
1147161002962	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161002963	DNA binding residues [nucleotide binding]
1147161002964	dimerization interface [polypeptide binding]; other site
1147161002965	Predicted flavoprotein [General function prediction only]; Region: COG0431
1147161002966	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147161002967	YhdB-like protein; Region: YhdB; pfam14148
1147161002968	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1147161002969	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002970	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002971	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002972	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002973	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002974	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161002975	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161002976	Transcriptional regulator; Region: Rrf2; cl17282
1147161002977	Rrf2 family protein; Region: rrf2_super; TIGR00738
1147161002978	Conserved TM helix; Region: TM_helix; pfam05552
1147161002979	Conserved TM helix; Region: TM_helix; pfam05552
1147161002980	Conserved TM helix; Region: TM_helix; pfam05552
1147161002981	Conserved TM helix; Region: TM_helix; pfam05552
1147161002982	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1147161002983	SpoVR like protein; Region: SpoVR; pfam04293
1147161002984	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1147161002985	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1147161002986	dimer interface [polypeptide binding]; other site
1147161002987	active site
1147161002988	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002989	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002990	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161002991	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161002992	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161002993	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161002994	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161002995	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161002996	dimerization interface [polypeptide binding]; other site
1147161002997	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
1147161002998	dimer interface [polypeptide binding]; other site
1147161002999	Citrate synthase; Region: Citrate_synt; pfam00285
1147161003000	active site
1147161003001	citrylCoA binding site [chemical binding]; other site
1147161003002	oxalacetate/citrate binding site [chemical binding]; other site
1147161003003	coenzyme A binding site [chemical binding]; other site
1147161003004	catalytic triad [active]
1147161003005	short chain dehydrogenase; Provisional; Region: PRK06701
1147161003006	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1147161003007	NAD binding site [chemical binding]; other site
1147161003008	metal binding site [ion binding]; metal-binding site
1147161003009	active site
1147161003010	amino acid transporter; Region: 2A0306; TIGR00909
1147161003011	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1147161003012	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1147161003013	Na2 binding site [ion binding]; other site
1147161003014	putative substrate binding site 1 [chemical binding]; other site
1147161003015	Na binding site 1 [ion binding]; other site
1147161003016	putative substrate binding site 2 [chemical binding]; other site
1147161003017	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161003018	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161003019	DNA-binding site [nucleotide binding]; DNA binding site
1147161003020	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161003021	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003022	homodimer interface [polypeptide binding]; other site
1147161003023	catalytic residue [active]
1147161003024	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1147161003025	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161003026	Coenzyme A binding pocket [chemical binding]; other site
1147161003027	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1147161003028	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1147161003029	RNA polymerase sigma factor SigM; Provisional; Region: PRK09644
1147161003030	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161003031	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161003032	DNA binding residues [nucleotide binding]
1147161003033	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161003034	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161003035	active site
1147161003036	catalytic tetrad [active]
1147161003037	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1147161003038	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1147161003039	putative acyl-acceptor binding pocket; other site
1147161003040	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1147161003041	Domain of unknown function DUF21; Region: DUF21; pfam01595
1147161003042	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1147161003043	Transporter associated domain; Region: CorC_HlyC; smart01091
1147161003044	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
1147161003045	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1147161003046	DNA binding residues [nucleotide binding]
1147161003047	putative dimer interface [polypeptide binding]; other site
1147161003048	aspartate aminotransferase; Provisional; Region: PRK06836
1147161003049	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161003050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003051	homodimer interface [polypeptide binding]; other site
1147161003052	catalytic residue [active]
1147161003053	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1147161003054	Domain of unknown function DUF21; Region: DUF21; pfam01595
1147161003055	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1147161003056	Transporter associated domain; Region: CorC_HlyC; smart01091
1147161003057	camphor resistance protein CrcB; Provisional; Region: PRK14213
1147161003058	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1147161003059	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1147161003060	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1147161003061	active site
1147161003062	catalytic site [active]
1147161003063	metal binding site [ion binding]; metal-binding site
1147161003064	dimer interface [polypeptide binding]; other site
1147161003065	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1147161003066	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1147161003067	NAD-dependent deacetylase; Provisional; Region: PRK00481
1147161003068	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1147161003069	NAD+ binding site [chemical binding]; other site
1147161003070	substrate binding site [chemical binding]; other site
1147161003071	Zn binding site [ion binding]; other site
1147161003072	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1147161003073	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1147161003074	NodB motif; other site
1147161003075	active site
1147161003076	catalytic site [active]
1147161003077	Zn binding site [ion binding]; other site
1147161003078	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1147161003079	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1147161003080	homodimer interface [polypeptide binding]; other site
1147161003081	substrate-cofactor binding pocket; other site
1147161003082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003083	catalytic residue [active]
1147161003084	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1147161003085	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1147161003086	Ligand Binding Site [chemical binding]; other site
1147161003087	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161003088	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1147161003089	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161003090	Walker A/P-loop; other site
1147161003091	ATP binding site [chemical binding]; other site
1147161003092	Q-loop/lid; other site
1147161003093	ABC transporter signature motif; other site
1147161003094	Walker B; other site
1147161003095	D-loop; other site
1147161003096	H-loop/switch region; other site
1147161003097	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161003098	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161003099	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1147161003100	Walker A/P-loop; other site
1147161003101	ATP binding site [chemical binding]; other site
1147161003102	Q-loop/lid; other site
1147161003103	ABC transporter signature motif; other site
1147161003104	Walker B; other site
1147161003105	D-loop; other site
1147161003106	H-loop/switch region; other site
1147161003107	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1147161003108	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1147161003109	NAD binding site [chemical binding]; other site
1147161003110	substrate binding site [chemical binding]; other site
1147161003111	putative active site [active]
1147161003112	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147161003113	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1147161003114	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1147161003115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1147161003116	hypothetical protein; Provisional; Region: PRK13676
1147161003117	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1147161003118	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1147161003119	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161003120	active site
1147161003121	motif I; other site
1147161003122	motif II; other site
1147161003123	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1147161003124	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
1147161003125	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161003126	FeS/SAM binding site; other site
1147161003127	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1147161003128	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1147161003129	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1147161003130	TrkA-C domain; Region: TrkA_C; pfam02080
1147161003131	enoyl-CoA hydratase; Provisional; Region: PRK07659
1147161003132	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161003133	substrate binding site [chemical binding]; other site
1147161003134	oxyanion hole (OAH) forming residues; other site
1147161003135	trimer interface [polypeptide binding]; other site
1147161003136	YhzD-like protein; Region: YhzD; pfam14120
1147161003137	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1147161003138	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
1147161003139	Walker A/P-loop; other site
1147161003140	ATP binding site [chemical binding]; other site
1147161003141	Q-loop/lid; other site
1147161003142	ABC transporter signature motif; other site
1147161003143	Walker B; other site
1147161003144	D-loop; other site
1147161003145	H-loop/switch region; other site
1147161003146	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1147161003147	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1147161003148	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147161003149	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1147161003150	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1147161003151	active site
1147161003152	metal binding site [ion binding]; metal-binding site
1147161003153	DNA binding site [nucleotide binding]
1147161003154	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1147161003155	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1147161003156	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1147161003157	generic binding surface II; other site
1147161003158	generic binding surface I; other site
1147161003159	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161003160	Zn2+ binding site [ion binding]; other site
1147161003161	Mg2+ binding site [ion binding]; other site
1147161003162	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
1147161003163	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1147161003164	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1147161003165	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1147161003166	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
1147161003167	transcriptional regulator Hpr; Provisional; Region: PRK13777
1147161003168	MarR family; Region: MarR; pfam01047
1147161003169	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1147161003170	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1147161003171	homodimer interface [polypeptide binding]; other site
1147161003172	substrate-cofactor binding pocket; other site
1147161003173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003174	catalytic residue [active]
1147161003175	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1147161003176	HIT family signature motif; other site
1147161003177	catalytic residue [active]
1147161003178	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1147161003179	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161003180	Walker A/P-loop; other site
1147161003181	ATP binding site [chemical binding]; other site
1147161003182	Q-loop/lid; other site
1147161003183	ABC transporter signature motif; other site
1147161003184	Walker B; other site
1147161003185	D-loop; other site
1147161003186	H-loop/switch region; other site
1147161003187	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1147161003188	EcsC protein family; Region: EcsC; pfam12787
1147161003189	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1147161003190	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1147161003191	metal binding site [ion binding]; metal-binding site
1147161003192	dimer interface [polypeptide binding]; other site
1147161003193	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1147161003194	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1147161003195	Transglycosylase; Region: Transgly; pfam00912
1147161003196	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161003197	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1147161003198	substrate binding site [chemical binding]; other site
1147161003199	active site
1147161003200	ferrochelatase; Provisional; Region: PRK12435
1147161003201	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1147161003202	C-terminal domain interface [polypeptide binding]; other site
1147161003203	active site
1147161003204	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1147161003205	active site
1147161003206	N-terminal domain interface [polypeptide binding]; other site
1147161003207	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1147161003208	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147161003209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161003210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161003211	Predicted membrane protein [Function unknown]; Region: COG1511
1147161003212	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1147161003213	Pex19 protein family; Region: Pex19; pfam04614
1147161003214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003215	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1147161003216	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1147161003217	dimer interface [polypeptide binding]; other site
1147161003218	active site
1147161003219	CoA binding pocket [chemical binding]; other site
1147161003220	Predicted membrane protein [Function unknown]; Region: COG4377
1147161003221	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1147161003222	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1147161003223	putative oligomer interface [polypeptide binding]; other site
1147161003224	putative active site [active]
1147161003225	metal binding site [ion binding]; metal-binding site
1147161003226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405
1147161003227	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1147161003228	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1147161003229	YhfH-like protein; Region: YhfH; pfam14149
1147161003230	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1147161003231	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1147161003232	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1147161003233	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1147161003234	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1147161003235	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1147161003236	NAD(P) binding site [chemical binding]; other site
1147161003237	putative active site [active]
1147161003238	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1147161003239	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1147161003240	acyl-activating enzyme (AAE) consensus motif; other site
1147161003241	putative AMP binding site [chemical binding]; other site
1147161003242	putative active site [active]
1147161003243	putative CoA binding site [chemical binding]; other site
1147161003244	Peptidase family M48; Region: Peptidase_M48; pfam01435
1147161003245	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1147161003246	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1147161003247	active site
1147161003248	catalytic residues [active]
1147161003249	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1147161003250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161003251	Coenzyme A binding pocket [chemical binding]; other site
1147161003252	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
1147161003253	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1147161003254	putative NADP binding site [chemical binding]; other site
1147161003255	putative dimer interface [polypeptide binding]; other site
1147161003256	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1147161003257	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1147161003258	siderophore binding site; other site
1147161003259	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1147161003260	catalytic core [active]
1147161003261	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
1147161003262	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1147161003263	dimer interface [polypeptide binding]; other site
1147161003264	active site
1147161003265	acyl-CoA synthetase; Validated; Region: PRK07638
1147161003266	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147161003267	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1147161003268	acyl-activating enzyme (AAE) consensus motif; other site
1147161003269	acyl-activating enzyme (AAE) consensus motif; other site
1147161003270	AMP binding site [chemical binding]; other site
1147161003271	active site
1147161003272	CoA binding site [chemical binding]; other site
1147161003273	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1147161003274	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1147161003275	heme-binding site [chemical binding]; other site
1147161003276	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147161003277	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161003278	dimer interface [polypeptide binding]; other site
1147161003279	putative CheW interface [polypeptide binding]; other site
1147161003280	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1147161003281	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1147161003282	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1147161003283	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1147161003284	[2Fe-2S] cluster binding site [ion binding]; other site
1147161003285	short chain dehydrogenase; Provisional; Region: PRK06701
1147161003286	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1147161003287	NAD binding site [chemical binding]; other site
1147161003288	metal binding site [ion binding]; metal-binding site
1147161003289	active site
1147161003290	IDEAL domain; Region: IDEAL; pfam08858
1147161003291	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1147161003292	oxidoreductase; Provisional; Region: PRK07985
1147161003293	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1147161003294	NAD binding site [chemical binding]; other site
1147161003295	metal binding site [ion binding]; metal-binding site
1147161003296	active site
1147161003297	Excalibur calcium-binding domain; Region: Excalibur; cl05460
1147161003298	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1147161003299	Na binding site [ion binding]; other site
1147161003300	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1147161003301	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1147161003302	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1147161003303	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1147161003304	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147161003305	Catalytic site [active]
1147161003306	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1147161003307	hypothetical protein; Provisional; Region: PRK08244
1147161003308	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1147161003309	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161003310	MarR family; Region: MarR; pfam01047
1147161003311	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1147161003312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003313	putative substrate translocation pore; other site
1147161003314	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161003315	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161003316	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161003317	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1147161003318	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161003319	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1147161003320	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147161003321	inhibitor-cofactor binding pocket; inhibition site
1147161003322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003323	catalytic residue [active]
1147161003324	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161003325	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161003326	DNA binding site [nucleotide binding]
1147161003327	domain linker motif; other site
1147161003328	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1147161003329	putative dimerization interface [polypeptide binding]; other site
1147161003330	putative ligand binding site [chemical binding]; other site
1147161003331	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1147161003332	Putative ammonia monooxygenase; Region: AmoA; pfam05145
1147161003333	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1147161003334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003335	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161003336	putative substrate translocation pore; other site
1147161003337	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1147161003338	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1147161003339	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1147161003340	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1147161003341	dimerization interface [polypeptide binding]; other site
1147161003342	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1147161003343	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1147161003344	dinuclear metal binding motif [ion binding]; other site
1147161003345	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1147161003346	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1147161003347	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1147161003348	Part of AAA domain; Region: AAA_19; pfam13245
1147161003349	Family description; Region: UvrD_C_2; pfam13538
1147161003350	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1147161003351	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1147161003352	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1147161003353	active site
1147161003354	metal binding site [ion binding]; metal-binding site
1147161003355	DNA binding site [nucleotide binding]
1147161003356	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1147161003357	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1147161003358	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1147161003359	Walker A/P-loop; other site
1147161003360	ATP binding site [chemical binding]; other site
1147161003361	Q-loop/lid; other site
1147161003362	ABC transporter signature motif; other site
1147161003363	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1147161003364	ABC transporter signature motif; other site
1147161003365	Walker B; other site
1147161003366	D-loop; other site
1147161003367	H-loop/switch region; other site
1147161003368	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1147161003369	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161003370	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1147161003371	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1147161003372	Spore germination protein GerPC; Region: GerPC; pfam10737
1147161003373	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
1147161003374	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161003375	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1147161003376	CotH protein; Region: CotH; pfam08757
1147161003377	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1147161003378	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1147161003379	hypothetical protein; Provisional; Region: PRK13673
1147161003380	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1147161003381	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1147161003382	active site
1147161003383	catalytic triad [active]
1147161003384	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
1147161003385	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1147161003386	active site
1147161003387	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1147161003388	dimer interface [polypeptide binding]; other site
1147161003389	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1147161003390	Ligand Binding Site [chemical binding]; other site
1147161003391	Molecular Tunnel; other site
1147161003392	DinB family; Region: DinB; cl17821
1147161003393	DinB superfamily; Region: DinB_2; pfam12867
1147161003394	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
1147161003395	substrate binding pocket [chemical binding]; other site
1147161003396	aspartate-rich region 2; other site
1147161003397	substrate-Mg2+ binding site; other site
1147161003398	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1147161003399	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1147161003400	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1147161003401	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161003402	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161003403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161003404	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161003405	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161003406	DNA binding site [nucleotide binding]
1147161003407	domain linker motif; other site
1147161003408	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1147161003409	dimerization interface [polypeptide binding]; other site
1147161003410	ligand binding site [chemical binding]; other site
1147161003411	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161003412	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161003413	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161003414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1147161003415	Lysine efflux permease [General function prediction only]; Region: COG1279
1147161003416	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1147161003417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161003418	DNA-binding site [nucleotide binding]; DNA binding site
1147161003419	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161003420	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003421	homodimer interface [polypeptide binding]; other site
1147161003422	catalytic residue [active]
1147161003423	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1147161003424	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1147161003425	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1147161003426	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161003427	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1147161003428	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1147161003429	ligand-binding site [chemical binding]; other site
1147161003430	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1147161003431	ATP-sulfurylase; Region: ATPS; cd00517
1147161003432	active site
1147161003433	HXXH motif; other site
1147161003434	flexible loop; other site
1147161003435	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1147161003436	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1147161003437	Active Sites [active]
1147161003438	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
1147161003439	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
1147161003440	(2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM    biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809
1147161003441	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161003442	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161003443	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1147161003444	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1147161003445	active site pocket [active]
1147161003446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003447	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161003448	putative substrate translocation pore; other site
1147161003449	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1147161003450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161003451	Coenzyme A binding pocket [chemical binding]; other site
1147161003452	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1147161003453	Coenzyme A binding pocket [chemical binding]; other site
1147161003454	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1147161003455	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1147161003456	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1147161003457	FAD binding site [chemical binding]; other site
1147161003458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1147161003459	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1147161003460	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1147161003461	S1 domain; Region: S1_2; pfam13509
1147161003462	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1147161003463	RNA binding site [nucleotide binding]; other site
1147161003464	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
1147161003465	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1147161003466	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
1147161003467	Predicted transcriptional regulators [Transcription]; Region: COG1695
1147161003468	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1147161003469	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1147161003470	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1147161003471	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147161003472	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1147161003473	active site
1147161003474	Zn binding site [ion binding]; other site
1147161003475	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147161003476	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147161003477	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161003478	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161003479	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161003480	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161003481	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
1147161003482	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
1147161003483	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1147161003484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161003485	motif II; other site
1147161003486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161003487	esterase; Provisional; Region: PRK10566
1147161003488	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1147161003489	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1147161003490	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1147161003491	FAD binding domain; Region: FAD_binding_4; pfam01565
1147161003492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161003494	putative substrate translocation pore; other site
1147161003495	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1147161003496	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1147161003497	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1147161003498	heterotetramer interface [polypeptide binding]; other site
1147161003499	active site pocket [active]
1147161003500	cleavage site
1147161003501	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1147161003502	nucleotide binding site [chemical binding]; other site
1147161003503	N-acetyl-L-glutamate binding site [chemical binding]; other site
1147161003504	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
1147161003505	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161003506	inhibitor-cofactor binding pocket; inhibition site
1147161003507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003508	catalytic residue [active]
1147161003509	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
1147161003510	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1147161003511	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1147161003512	catalytic site [active]
1147161003513	subunit interface [polypeptide binding]; other site
1147161003514	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815
1147161003515	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161003516	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147161003517	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1147161003518	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161003519	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147161003520	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1147161003521	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1147161003522	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1147161003523	YjzC-like protein; Region: YjzC; pfam14168
1147161003524	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1147161003525	UDP-apiose/xylose synthase; Region: PLN02427
1147161003526	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1147161003527	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1147161003528	putative ligand binding site [chemical binding]; other site
1147161003529	ComZ; Region: ComZ; pfam10815
1147161003530	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1147161003531	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1147161003532	dimer interface [polypeptide binding]; other site
1147161003533	active site
1147161003534	CoA binding pocket [chemical binding]; other site
1147161003535	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1147161003536	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1147161003537	dimer interface [polypeptide binding]; other site
1147161003538	active site
1147161003539	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1147161003540	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1147161003541	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1147161003542	Walker A/P-loop; other site
1147161003543	ATP binding site [chemical binding]; other site
1147161003544	Q-loop/lid; other site
1147161003545	ABC transporter signature motif; other site
1147161003546	Walker B; other site
1147161003547	D-loop; other site
1147161003548	H-loop/switch region; other site
1147161003549	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1147161003550	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1147161003551	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1147161003552	Walker A/P-loop; other site
1147161003553	ATP binding site [chemical binding]; other site
1147161003554	Q-loop/lid; other site
1147161003555	ABC transporter signature motif; other site
1147161003556	Walker B; other site
1147161003557	D-loop; other site
1147161003558	H-loop/switch region; other site
1147161003559	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1147161003560	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1147161003561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161003562	dimer interface [polypeptide binding]; other site
1147161003563	conserved gate region; other site
1147161003564	putative PBP binding loops; other site
1147161003565	ABC-ATPase subunit interface; other site
1147161003566	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1147161003567	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1147161003568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161003569	dimer interface [polypeptide binding]; other site
1147161003570	conserved gate region; other site
1147161003571	putative PBP binding loops; other site
1147161003572	ABC-ATPase subunit interface; other site
1147161003573	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
1147161003574	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1147161003575	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1147161003576	active site
1147161003577	HIGH motif; other site
1147161003578	dimer interface [polypeptide binding]; other site
1147161003579	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1147161003580	KMSKS motif; other site
1147161003581	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1147161003582	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1147161003583	peptide binding site [polypeptide binding]; other site
1147161003584	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1147161003585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161003586	dimer interface [polypeptide binding]; other site
1147161003587	conserved gate region; other site
1147161003588	putative PBP binding loops; other site
1147161003589	ABC-ATPase subunit interface; other site
1147161003590	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1147161003591	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1147161003592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161003593	dimer interface [polypeptide binding]; other site
1147161003594	conserved gate region; other site
1147161003595	putative PBP binding loops; other site
1147161003596	ABC-ATPase subunit interface; other site
1147161003597	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1147161003598	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1147161003599	Walker A/P-loop; other site
1147161003600	ATP binding site [chemical binding]; other site
1147161003601	Q-loop/lid; other site
1147161003602	ABC transporter signature motif; other site
1147161003603	Walker B; other site
1147161003604	D-loop; other site
1147161003605	H-loop/switch region; other site
1147161003606	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1147161003607	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1147161003608	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1147161003609	Walker A/P-loop; other site
1147161003610	ATP binding site [chemical binding]; other site
1147161003611	Q-loop/lid; other site
1147161003612	ABC transporter signature motif; other site
1147161003613	Walker B; other site
1147161003614	D-loop; other site
1147161003615	H-loop/switch region; other site
1147161003616	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1147161003617	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147161003618	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1147161003619	ArsC family; Region: ArsC; pfam03960
1147161003620	putative catalytic residues [active]
1147161003621	thiol/disulfide switch; other site
1147161003622	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1147161003623	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
1147161003624	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
1147161003625	oligoendopeptidase F; Region: pepF; TIGR00181
1147161003626	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1147161003627	active site
1147161003628	Zn binding site [ion binding]; other site
1147161003629	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1147161003630	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1147161003631	catalytic residues [active]
1147161003632	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1147161003633	apolar tunnel; other site
1147161003634	heme binding site [chemical binding]; other site
1147161003635	dimerization interface [polypeptide binding]; other site
1147161003636	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1147161003637	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147161003638	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147161003639	catalytic residue [active]
1147161003640	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1147161003641	putative active site [active]
1147161003642	putative metal binding residues [ion binding]; other site
1147161003643	signature motif; other site
1147161003644	putative triphosphate binding site [ion binding]; other site
1147161003645	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1147161003646	synthetase active site [active]
1147161003647	NTP binding site [chemical binding]; other site
1147161003648	metal binding site [ion binding]; metal-binding site
1147161003649	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1147161003650	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1147161003651	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1147161003652	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1147161003653	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147161003654	active site
1147161003655	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
1147161003656	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
1147161003657	active site
1147161003658	metal binding site [ion binding]; metal-binding site
1147161003659	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1147161003660	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1147161003661	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1147161003662	TrkA-N domain; Region: TrkA_N; pfam02254
1147161003663	TrkA-C domain; Region: TrkA_C; pfam02080
1147161003664	thiaminase II; Region: salvage_TenA; TIGR04306
1147161003665	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1147161003666	thiamine phosphate binding site [chemical binding]; other site
1147161003667	active site
1147161003668	pyrophosphate binding site [ion binding]; other site
1147161003669	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1147161003670	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1147161003671	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1147161003672	thiS-thiF/thiG interaction site; other site
1147161003673	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1147161003674	ThiS interaction site; other site
1147161003675	putative active site [active]
1147161003676	tetramer interface [polypeptide binding]; other site
1147161003677	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1147161003678	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1147161003679	ATP binding site [chemical binding]; other site
1147161003680	substrate interface [chemical binding]; other site
1147161003681	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1147161003682	dimer interface [polypeptide binding]; other site
1147161003683	substrate binding site [chemical binding]; other site
1147161003684	ATP binding site [chemical binding]; other site
1147161003685	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1147161003686	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1147161003687	NAD binding site [chemical binding]; other site
1147161003688	homotetramer interface [polypeptide binding]; other site
1147161003689	homodimer interface [polypeptide binding]; other site
1147161003690	substrate binding site [chemical binding]; other site
1147161003691	active site
1147161003692	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
1147161003693	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
1147161003694	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
1147161003695	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
1147161003696	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
1147161003697	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
1147161003698	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
1147161003699	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1147161003700	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1147161003701	Part of AAA domain; Region: AAA_19; pfam13245
1147161003702	Family description; Region: UvrD_C_2; pfam13538
1147161003703	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161003704	Coenzyme A binding pocket [chemical binding]; other site
1147161003705	hypothetical protein; Provisional; Region: PRK13679
1147161003706	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1147161003707	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1147161003708	Putative esterase; Region: Esterase; pfam00756
1147161003709	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1147161003710	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1147161003711	homodimer interface [polypeptide binding]; other site
1147161003712	substrate-cofactor binding pocket; other site
1147161003713	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003714	catalytic residue [active]
1147161003715	cystathionine beta-lyase; Provisional; Region: PRK08064
1147161003716	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1147161003717	homodimer interface [polypeptide binding]; other site
1147161003718	substrate-cofactor binding pocket; other site
1147161003719	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161003720	catalytic residue [active]
1147161003721	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161003722	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1147161003723	Predicted integral membrane protein [Function unknown]; Region: COG5505
1147161003724	Putative amidase domain; Region: Amidase_6; pfam12671
1147161003725	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147161003726	YjcQ protein; Region: YjcQ; pfam09639
1147161003727	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1147161003728	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1147161003729	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1147161003730	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
1147161003731	classical (c) SDRs; Region: SDR_c; cd05233
1147161003732	NAD(P) binding site [chemical binding]; other site
1147161003733	active site
1147161003734	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1147161003735	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1147161003736	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1147161003737	HTH domain; Region: HTH_11; pfam08279
1147161003738	PRD domain; Region: PRD; pfam00874
1147161003739	PRD domain; Region: PRD; pfam00874
1147161003740	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1147161003741	active site
1147161003742	P-loop; other site
1147161003743	phosphorylation site [posttranslational modification]
1147161003744	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1147161003745	active site
1147161003746	phosphorylation site [posttranslational modification]
1147161003747	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1147161003748	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1147161003749	active site
1147161003750	P-loop; other site
1147161003751	phosphorylation site [posttranslational modification]
1147161003752	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1147161003753	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1147161003754	active site
1147161003755	phosphorylation site [posttranslational modification]
1147161003756	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1147161003757	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1147161003758	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1147161003759	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161003760	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147161003761	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1147161003762	putative deacylase active site [active]
1147161003763	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1147161003764	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
1147161003765	Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109
1147161003766	UbiA prenyltransferase family; Region: UbiA; pfam01040
1147161003767	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1147161003768	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1147161003769	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1147161003770	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
1147161003771	NodB motif; other site
1147161003772	active site
1147161003773	catalytic site [active]
1147161003774	Zn binding site [ion binding]; other site
1147161003775	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
1147161003776	Putative motility protein; Region: YjfB_motility; pfam14070
1147161003777	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1147161003778	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1147161003779	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
1147161003780	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1147161003781	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1147161003782	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1147161003783	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1147161003784	4Fe-4S binding domain; Region: Fer4; pfam00037
1147161003785	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1147161003786	[4Fe-4S] binding site [ion binding]; other site
1147161003787	molybdopterin cofactor binding site; other site
1147161003788	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1147161003789	molybdopterin cofactor binding site; other site
1147161003790	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1147161003791	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1147161003792	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1147161003793	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1147161003794	nudix motif; other site
1147161003795	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161003796	Cytochrome P450; Region: p450; cl12078
1147161003797	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1147161003798	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1147161003799	active site
1147161003800	TDP-binding site; other site
1147161003801	acceptor substrate-binding pocket; other site
1147161003802	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1147161003803	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1147161003804	active site
1147161003805	TIGR00245 family protein; Region: TIGR00245
1147161003806	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1147161003807	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1147161003808	Walker A/P-loop; other site
1147161003809	ATP binding site [chemical binding]; other site
1147161003810	Q-loop/lid; other site
1147161003811	ABC transporter signature motif; other site
1147161003812	Walker B; other site
1147161003813	D-loop; other site
1147161003814	H-loop/switch region; other site
1147161003815	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1147161003816	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
1147161003817	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1147161003818	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1147161003819	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161003820	Glucuronate isomerase; Region: UxaC; pfam02614
1147161003821	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1147161003822	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1147161003823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003824	putative substrate translocation pore; other site
1147161003825	Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615
1147161003826	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1147161003827	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1147161003828	putative NAD(P) binding site [chemical binding]; other site
1147161003829	catalytic Zn binding site [ion binding]; other site
1147161003830	structural Zn binding site [ion binding]; other site
1147161003831	mannonate dehydratase; Provisional; Region: PRK03906
1147161003832	mannonate dehydratase; Region: uxuA; TIGR00695
1147161003833	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1147161003834	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
1147161003835	putative NAD(P) binding site [chemical binding]; other site
1147161003836	active site
1147161003837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161003838	D-galactonate transporter; Region: 2A0114; TIGR00893
1147161003839	putative substrate translocation pore; other site
1147161003840	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161003841	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161003842	DNA binding site [nucleotide binding]
1147161003843	domain linker motif; other site
1147161003844	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1147161003845	dimerization interface [polypeptide binding]; other site
1147161003846	ligand binding site [chemical binding]; other site
1147161003847	altronate oxidoreductase; Provisional; Region: PRK03643
1147161003848	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1147161003849	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1147161003850	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1147161003851	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1147161003852	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1147161003853	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1147161003854	DinB family; Region: DinB; pfam05163
1147161003855	DinB superfamily; Region: DinB_2; pfam12867
1147161003856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161003857	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161003858	Walker A motif; other site
1147161003859	ATP binding site [chemical binding]; other site
1147161003860	Walker B motif; other site
1147161003861	arginine finger; other site
1147161003862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161003863	binding surface
1147161003864	TPR motif; other site
1147161003865	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161003866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161003867	binding surface
1147161003868	TPR motif; other site
1147161003869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
1147161003870	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1147161003871	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1147161003872	amidase catalytic site [active]
1147161003873	Zn binding residues [ion binding]; other site
1147161003874	substrate binding site [chemical binding]; other site
1147161003875	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147161003876	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161003877	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147161003878	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161003879	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1147161003880	pentamer interface [polypeptide binding]; other site
1147161003881	dodecaamer interface [polypeptide binding]; other site
1147161003882	Phage-related replication protein [General function prediction only]; Region: COG4195
1147161003883	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1147161003884	dimanganese center [ion binding]; other site
1147161003885	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1147161003886	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161003887	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161003888	non-specific DNA binding site [nucleotide binding]; other site
1147161003889	salt bridge; other site
1147161003890	sequence-specific DNA binding site [nucleotide binding]; other site
1147161003891	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1147161003892	putative Zn2+ binding site [ion binding]; other site
1147161003893	putative DNA binding site [nucleotide binding]; other site
1147161003894	hypothetical protein; Provisional; Region: PRK06921
1147161003895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161003896	Walker A motif; other site
1147161003897	ATP binding site [chemical binding]; other site
1147161003898	Walker B motif; other site
1147161003899	positive control sigma-like factor; Validated; Region: PRK06930
1147161003900	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161003901	DNA binding residues [nucleotide binding]
1147161003902	Phage terminase small subunit; Region: Phage_terminase; pfam10668
1147161003903	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
1147161003904	Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783
1147161003905	Terminase-like family; Region: Terminase_6; pfam03237
1147161003906	Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518
1147161003907	Phage capsid family; Region: Phage_capsid; pfam05065
1147161003908	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
1147161003909	Domain of unknown function (DUF3599); Region: DUF3599; pfam12206
1147161003910	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
1147161003911	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
1147161003912	Phage XkdN-like protein; Region: XkdN; pfam08890
1147161003913	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1147161003914	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147161003915	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147161003916	catalytic residue [active]
1147161003917	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1147161003918	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161003919	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
1147161003920	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
1147161003921	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
1147161003922	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
1147161003923	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
1147161003924	XkdW protein; Region: XkdW; pfam09636
1147161003925	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
1147161003926	Haemolysin XhlA; Region: XhlA; pfam10779
1147161003927	holin, SPP1 family; Region: holin_SPP1; TIGR01592
1147161003928	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1147161003929	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1147161003930	amidase catalytic site [active]
1147161003931	Zn binding residues [ion binding]; other site
1147161003932	substrate binding site [chemical binding]; other site
1147161003933	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161003934	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147161003935	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161003936	Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185
1147161003937	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
1147161003938	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1147161003939	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1147161003940	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
1147161003941	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1147161003942	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161003943	Zn binding site [ion binding]; other site
1147161003944	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1147161003945	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161003946	Zn binding site [ion binding]; other site
1147161003947	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1147161003948	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1147161003949	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1147161003950	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1147161003951	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1147161003952	Ligand binding site; other site
1147161003953	Putative Catalytic site; other site
1147161003954	DXD motif; other site
1147161003955	Trypsin; Region: Trypsin; pfam00089
1147161003956	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1147161003957	protein binding site [polypeptide binding]; other site
1147161003958	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
1147161003959	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1147161003960	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281
1147161003961	SxDxEG motif; other site
1147161003962	active site
1147161003963	metal binding site [ion binding]; metal-binding site
1147161003964	homopentamer interface [polypeptide binding]; other site
1147161003965	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1147161003966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161003967	dimer interface [polypeptide binding]; other site
1147161003968	conserved gate region; other site
1147161003969	putative PBP binding loops; other site
1147161003970	ABC-ATPase subunit interface; other site
1147161003971	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1147161003972	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1147161003973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161003974	dimer interface [polypeptide binding]; other site
1147161003975	conserved gate region; other site
1147161003976	putative PBP binding loops; other site
1147161003977	ABC-ATPase subunit interface; other site
1147161003978	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1147161003979	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1147161003980	Walker A/P-loop; other site
1147161003981	ATP binding site [chemical binding]; other site
1147161003982	Q-loop/lid; other site
1147161003983	ABC transporter signature motif; other site
1147161003984	Walker B; other site
1147161003985	D-loop; other site
1147161003986	H-loop/switch region; other site
1147161003987	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1147161003988	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1147161003989	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1147161003990	peptide binding site [polypeptide binding]; other site
1147161003991	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1147161003992	dimer interface [polypeptide binding]; other site
1147161003993	catalytic triad [active]
1147161003994	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1147161003995	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1147161003996	active site
1147161003997	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161003998	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161003999	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1147161004000	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1147161004001	Walker A/P-loop; other site
1147161004002	ATP binding site [chemical binding]; other site
1147161004003	Q-loop/lid; other site
1147161004004	ABC transporter signature motif; other site
1147161004005	Walker B; other site
1147161004006	D-loop; other site
1147161004007	H-loop/switch region; other site
1147161004008	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1147161004009	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1147161004010	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1147161004011	Amidinotransferase; Region: Amidinotransf; pfam02274
1147161004012	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1147161004013	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1147161004014	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1147161004015	heme-binding site [chemical binding]; other site
1147161004016	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1147161004017	FAD binding pocket [chemical binding]; other site
1147161004018	FAD binding motif [chemical binding]; other site
1147161004019	phosphate binding motif [ion binding]; other site
1147161004020	beta-alpha-beta structure motif; other site
1147161004021	NAD binding pocket [chemical binding]; other site
1147161004022	Heme binding  pocket [chemical binding]; other site
1147161004023	Predicted membrane protein [Function unknown]; Region: COG2323
1147161004024	DinB superfamily; Region: DinB_2; pfam12867
1147161004025	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1147161004026	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147161004027	ykkC-yxkD; BSU6051_1308010
1147161004028	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1147161004029	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1147161004030	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1147161004031	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1147161004032	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1147161004033	putative active site [active]
1147161004034	putative substrate binding site [chemical binding]; other site
1147161004035	putative cosubstrate binding site; other site
1147161004036	catalytic site [active]
1147161004037	glutamate 5-kinase; Region: proB; TIGR01027
1147161004038	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1147161004039	nucleotide binding site [chemical binding]; other site
1147161004040	homotetrameric interface [polypeptide binding]; other site
1147161004041	putative phosphate binding site [ion binding]; other site
1147161004042	putative allosteric binding site; other site
1147161004043	PUA domain; Region: PUA; pfam01472
1147161004044	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1147161004045	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1147161004046	putative catalytic cysteine [active]
1147161004047	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1147161004048	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161004049	MarR family; Region: MarR; pfam01047
1147161004050	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1147161004051	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1147161004052	nucleoside/Zn binding site; other site
1147161004053	dimer interface [polypeptide binding]; other site
1147161004054	catalytic motif [active]
1147161004055	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1147161004056	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
1147161004057	THF binding site; other site
1147161004058	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1147161004059	substrate binding site [chemical binding]; other site
1147161004060	THF binding site; other site
1147161004061	zinc-binding site [ion binding]; other site
1147161004062	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1147161004063	active site
1147161004064	catalytic residues [active]
1147161004065	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1147161004066	Cobalt transport protein; Region: CbiQ; pfam02361
1147161004067	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1147161004068	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147161004069	Walker A/P-loop; other site
1147161004070	ATP binding site [chemical binding]; other site
1147161004071	Q-loop/lid; other site
1147161004072	ABC transporter signature motif; other site
1147161004073	Walker B; other site
1147161004074	D-loop; other site
1147161004075	H-loop/switch region; other site
1147161004076	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147161004077	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1147161004078	Walker A/P-loop; other site
1147161004079	ATP binding site [chemical binding]; other site
1147161004080	Q-loop/lid; other site
1147161004081	ABC transporter signature motif; other site
1147161004082	Walker B; other site
1147161004083	D-loop; other site
1147161004084	H-loop/switch region; other site
1147161004085	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1147161004086	YKOF-related Family; Region: Ykof; pfam07615
1147161004087	YKOF-related Family; Region: Ykof; pfam07615
1147161004088	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161004089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161004090	active site
1147161004091	phosphorylation site [posttranslational modification]
1147161004092	intermolecular recognition site; other site
1147161004093	dimerization interface [polypeptide binding]; other site
1147161004094	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161004095	DNA binding site [nucleotide binding]
1147161004096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161004097	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161004098	dimerization interface [polypeptide binding]; other site
1147161004099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161004100	dimer interface [polypeptide binding]; other site
1147161004101	phosphorylation site [posttranslational modification]
1147161004102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161004103	ATP binding site [chemical binding]; other site
1147161004104	Mg2+ binding site [ion binding]; other site
1147161004105	G-X-G motif; other site
1147161004106	Predicted membrane protein [Function unknown]; Region: COG3212
1147161004107	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147161004108	Predicted membrane protein [Function unknown]; Region: COG3212
1147161004109	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147161004110	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
1147161004111	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
1147161004112	MgtE intracellular N domain; Region: MgtE_N; smart00924
1147161004113	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1147161004114	Divalent cation transporter; Region: MgtE; pfam01769
1147161004115	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1147161004116	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147161004117	DNA binding residues [nucleotide binding]
1147161004118	putative dimer interface [polypeptide binding]; other site
1147161004119	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161004120	MarR family; Region: MarR; pfam01047
1147161004121	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
1147161004122	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1147161004123	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1147161004124	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161004125	putative active site [active]
1147161004126	putative metal binding site [ion binding]; other site
1147161004127	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1147161004128	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161004129	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1147161004130	Ligand binding site; other site
1147161004131	Putative Catalytic site; other site
1147161004132	DXD motif; other site
1147161004133	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633
1147161004134	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1147161004135	active site
1147161004136	DNA binding site [nucleotide binding]
1147161004137	LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866
1147161004138	nucleotide binding site [chemical binding]; other site
1147161004139	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1147161004140	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1147161004141	putative DNA binding site [nucleotide binding]; other site
1147161004142	putative homodimer interface [polypeptide binding]; other site
1147161004143	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1147161004144	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1147161004145	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1147161004146	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1147161004147	PAS domain; Region: PAS_9; pfam13426
1147161004148	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147161004149	metal binding site [ion binding]; metal-binding site
1147161004150	active site
1147161004151	I-site; other site
1147161004152	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1147161004153	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1147161004154	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1147161004155	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1147161004156	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
1147161004157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161004158	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
1147161004159	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147161004160	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1147161004161	heat shock protein HtpX; Provisional; Region: PRK05457
1147161004162	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1147161004163	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1147161004164	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1147161004165	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1147161004166	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161004167	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147161004168	putative active site [active]
1147161004169	heme pocket [chemical binding]; other site
1147161004170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1147161004171	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147161004172	putative active site [active]
1147161004173	heme pocket [chemical binding]; other site
1147161004174	PAS domain; Region: PAS; smart00091
1147161004175	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1147161004176	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161004177	putative active site [active]
1147161004178	heme pocket [chemical binding]; other site
1147161004179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161004180	dimer interface [polypeptide binding]; other site
1147161004181	phosphorylation site [posttranslational modification]
1147161004182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161004183	ATP binding site [chemical binding]; other site
1147161004184	Mg2+ binding site [ion binding]; other site
1147161004185	G-X-G motif; other site
1147161004186	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1147161004187	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1147161004188	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1147161004189	DNA binding site [nucleotide binding]
1147161004190	active site
1147161004191	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1147161004192	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
1147161004193	Predicted kinase [General function prediction only]; Region: COG4857
1147161004194	Phosphotransferase enzyme family; Region: APH; pfam01636
1147161004195	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1147161004196	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1147161004197	putative active site [active]
1147161004198	catalytic triad [active]
1147161004199	putative dimer interface [polypeptide binding]; other site
1147161004200	transaminase; Reviewed; Region: PRK08068
1147161004201	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161004202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161004203	homodimer interface [polypeptide binding]; other site
1147161004204	catalytic residue [active]
1147161004205	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332
1147161004206	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1147161004207	dimer interface [polypeptide binding]; other site
1147161004208	active site
1147161004209	catalytic residue [active]
1147161004210	metal binding site [ion binding]; metal-binding site
1147161004211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161004212	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1147161004213	motif II; other site
1147161004214	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
1147161004215	intersubunit interface [polypeptide binding]; other site
1147161004216	active site
1147161004217	Zn2+ binding site [ion binding]; other site
1147161004218	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1147161004219	Cupin domain; Region: Cupin_2; pfam07883
1147161004220	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1147161004221	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1147161004222	Cache domain; Region: Cache_1; pfam02743
1147161004223	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1147161004224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161004225	dimer interface [polypeptide binding]; other site
1147161004226	phosphorylation site [posttranslational modification]
1147161004227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161004228	ATP binding site [chemical binding]; other site
1147161004229	Mg2+ binding site [ion binding]; other site
1147161004230	G-X-G motif; other site
1147161004231	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161004232	MarR family; Region: MarR; pfam01047
1147161004233	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1147161004234	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1147161004235	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1147161004236	ligand binding site [chemical binding]; other site
1147161004237	flagellar motor protein MotA; Validated; Region: PRK08124
1147161004238	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1147161004239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161004240	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161004241	Walker A motif; other site
1147161004242	ATP binding site [chemical binding]; other site
1147161004243	Walker B motif; other site
1147161004244	arginine finger; other site
1147161004245	UvrB/uvrC motif; Region: UVR; pfam02151
1147161004246	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161004247	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161004248	Walker A motif; other site
1147161004249	ATP binding site [chemical binding]; other site
1147161004250	Walker B motif; other site
1147161004251	arginine finger; other site
1147161004252	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1147161004253	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1147161004254	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1147161004255	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1147161004256	Ligand Binding Site [chemical binding]; other site
1147161004257	6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039
1147161004258	active site
1147161004259	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1147161004260	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161004261	FeS/SAM binding site; other site
1147161004262	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1147161004263	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161004264	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161004265	short chain dehydrogenase; Provisional; Region: PRK06500
1147161004266	classical (c) SDRs; Region: SDR_c; cd05233
1147161004267	NAD(P) binding site [chemical binding]; other site
1147161004268	active site
1147161004269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1147161004270	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147161004271	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1147161004272	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147161004273	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161004274	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147161004275	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161004276	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1147161004277	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1147161004278	active site
1147161004279	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1147161004280	Protein of unknown function (DUF3219); Region: DUF3219; pfam11514
1147161004281	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
1147161004282	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1147161004283	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1147161004284	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1147161004285	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1147161004286	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161004287	catalytic residues [active]
1147161004288	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1147161004289	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147161004290	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161004291	motif II; other site
1147161004292	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1147161004293	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1147161004294	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1147161004295	active site
1147161004296	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161004297	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161004298	DNA binding site [nucleotide binding]
1147161004299	domain linker motif; other site
1147161004300	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1147161004301	putative dimerization interface [polypeptide binding]; other site
1147161004302	putative ligand binding site [chemical binding]; other site
1147161004303	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1147161004304	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1147161004305	PRD domain; Region: PRD; pfam00874
1147161004306	PRD domain; Region: PRD; pfam00874
1147161004307	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161004308	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1147161004309	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161004310	active site turn [active]
1147161004311	phosphorylation site [posttranslational modification]
1147161004312	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1147161004313	HPr interaction site; other site
1147161004314	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1147161004315	active site
1147161004316	phosphorylation site [posttranslational modification]
1147161004317	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1147161004318	dimerization domain swap beta strand [polypeptide binding]; other site
1147161004319	regulatory protein interface [polypeptide binding]; other site
1147161004320	active site
1147161004321	regulatory phosphorylation site [posttranslational modification]; other site
1147161004322	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1147161004323	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1147161004324	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1147161004325	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1147161004326	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
1147161004327	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1147161004328	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161004329	FeS/SAM binding site; other site
1147161004330	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161004331	Coenzyme A binding pocket [chemical binding]; other site
1147161004332	Cache domain; Region: Cache_1; pfam02743
1147161004333	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161004334	dimerization interface [polypeptide binding]; other site
1147161004335	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147161004336	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161004337	dimer interface [polypeptide binding]; other site
1147161004338	putative CheW interface [polypeptide binding]; other site
1147161004339	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1147161004340	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1147161004341	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1147161004342	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1147161004343	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161004344	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161004345	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1147161004346	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161004347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161004348	putative active site [active]
1147161004349	heme pocket [chemical binding]; other site
1147161004350	PAS fold; Region: PAS; pfam00989
1147161004351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161004352	putative active site [active]
1147161004353	heme pocket [chemical binding]; other site
1147161004354	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1147161004355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161004356	putative active site [active]
1147161004357	heme pocket [chemical binding]; other site
1147161004358	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161004359	dimer interface [polypeptide binding]; other site
1147161004360	phosphorylation site [posttranslational modification]
1147161004361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161004362	ATP binding site [chemical binding]; other site
1147161004363	Mg2+ binding site [ion binding]; other site
1147161004364	G-X-G motif; other site
1147161004365	aminotransferase A; Validated; Region: PRK07683
1147161004366	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161004367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161004368	homodimer interface [polypeptide binding]; other site
1147161004369	catalytic residue [active]
1147161004370	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1147161004371	putative CheA interaction surface; other site
1147161004372	Response regulator receiver domain; Region: Response_reg; pfam00072
1147161004373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161004374	active site
1147161004375	phosphorylation site [posttranslational modification]
1147161004376	intermolecular recognition site; other site
1147161004377	dimerization interface [polypeptide binding]; other site
1147161004378	YkyB-like protein; Region: YkyB; pfam14177
1147161004379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161004380	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147161004381	putative substrate translocation pore; other site
1147161004382	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161004383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1147161004384	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1147161004385	phosphodiesterase YaeI; Provisional; Region: PRK11340
1147161004386	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1147161004387	putative active site [active]
1147161004388	putative metal binding site [ion binding]; other site
1147161004389	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1147161004390	short chain dehydrogenase; Provisional; Region: PRK07677
1147161004391	NAD(P) binding site [chemical binding]; other site
1147161004392	substrate binding site [chemical binding]; other site
1147161004393	homotetramer interface [polypeptide binding]; other site
1147161004394	active site
1147161004395	homodimer interface [polypeptide binding]; other site
1147161004396	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1147161004397	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
1147161004398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
1147161004399	Protein of unknown function (DUF458); Region: DUF458; pfam04308
1147161004400	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
1147161004401	FOG: CBS domain [General function prediction only]; Region: COG0517
1147161004402	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1147161004403	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161004404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161004405	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161004406	dimerization interface [polypeptide binding]; other site
1147161004407	flavodoxin; Provisional; Region: PRK06703
1147161004408	BNR repeat-like domain; Region: BNR_2; pfam13088
1147161004409	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1147161004410	flavodoxin, short chain; Region: flav_short; TIGR01753
1147161004411	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1147161004412	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1147161004413	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1147161004414	active site
1147161004415	trimer interface [polypeptide binding]; other site
1147161004416	substrate binding site [chemical binding]; other site
1147161004417	CoA binding site [chemical binding]; other site
1147161004418	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1147161004419	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1147161004420	metal binding site [ion binding]; metal-binding site
1147161004421	putative dimer interface [polypeptide binding]; other site
1147161004422	hypothetical protein; Provisional; Region: PRK03094
1147161004423	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1147161004424	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1147161004425	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1147161004426	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1147161004427	dimer interface [polypeptide binding]; other site
1147161004428	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1147161004429	catalytic triad [active]
1147161004430	peroxidatic and resolving cysteines [active]
1147161004431	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1147161004432	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161004433	catalytic residues [active]
1147161004434	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1147161004435	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1147161004436	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1147161004437	GTP binding site; other site
1147161004438	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1147161004439	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1147161004440	ATP binding site [chemical binding]; other site
1147161004441	substrate interface [chemical binding]; other site
1147161004442	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1147161004443	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1147161004444	dimer interface [polypeptide binding]; other site
1147161004445	putative functional site; other site
1147161004446	putative MPT binding site; other site
1147161004447	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1147161004448	Walker A motif; other site
1147161004449	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1147161004450	MoaE homodimer interface [polypeptide binding]; other site
1147161004451	MoaD interaction [polypeptide binding]; other site
1147161004452	active site residues [active]
1147161004453	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1147161004454	MoaE interaction surface [polypeptide binding]; other site
1147161004455	MoeB interaction surface [polypeptide binding]; other site
1147161004456	thiocarboxylated glycine; other site
1147161004457	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161004458	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161004459	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1147161004460	Walker A/P-loop; other site
1147161004461	ATP binding site [chemical binding]; other site
1147161004462	Q-loop/lid; other site
1147161004463	ABC transporter signature motif; other site
1147161004464	Walker B; other site
1147161004465	D-loop; other site
1147161004466	H-loop/switch region; other site
1147161004467	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161004468	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161004469	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1147161004470	Walker A/P-loop; other site
1147161004471	ATP binding site [chemical binding]; other site
1147161004472	Q-loop/lid; other site
1147161004473	ABC transporter signature motif; other site
1147161004474	Walker B; other site
1147161004475	D-loop; other site
1147161004476	H-loop/switch region; other site
1147161004477	Yip1 domain; Region: Yip1; pfam04893
1147161004478	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
1147161004479	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1147161004480	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147161004481	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161004482	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161004483	Walker A/P-loop; other site
1147161004484	ATP binding site [chemical binding]; other site
1147161004485	Q-loop/lid; other site
1147161004486	ABC transporter signature motif; other site
1147161004487	Walker B; other site
1147161004488	D-loop; other site
1147161004489	H-loop/switch region; other site
1147161004490	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1147161004491	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147161004492	FtsX-like permease family; Region: FtsX; pfam02687
1147161004493	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147161004494	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1147161004495	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1147161004496	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1147161004497	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1147161004498	putative substrate binding site [chemical binding]; other site
1147161004499	putative ATP binding site [chemical binding]; other site
1147161004500	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1147161004501	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1147161004502	active site
1147161004503	phosphorylation site [posttranslational modification]
1147161004504	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1147161004505	active site
1147161004506	P-loop; other site
1147161004507	phosphorylation site [posttranslational modification]
1147161004508	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1147161004509	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1147161004510	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147161004511	Catalytic site [active]
1147161004512	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1147161004513	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161004514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161004515	ABC transporter; Region: ABC_tran_2; pfam12848
1147161004516	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147161004517	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1147161004518	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1147161004519	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1147161004520	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1147161004521	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1147161004522	rod-share determining protein MreBH; Provisional; Region: PRK13929
1147161004523	MreB and similar proteins; Region: MreB_like; cd10225
1147161004524	nucleotide binding site [chemical binding]; other site
1147161004525	Mg binding site [ion binding]; other site
1147161004526	putative protofilament interaction site [polypeptide binding]; other site
1147161004527	RodZ interaction site [polypeptide binding]; other site
1147161004528	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1147161004529	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1147161004530	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1147161004531	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161004532	putative active site [active]
1147161004533	heme pocket [chemical binding]; other site
1147161004534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161004535	dimer interface [polypeptide binding]; other site
1147161004536	phosphorylation site [posttranslational modification]
1147161004537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161004538	ATP binding site [chemical binding]; other site
1147161004539	Mg2+ binding site [ion binding]; other site
1147161004540	G-X-G motif; other site
1147161004541	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1147161004542	putative active site pocket [active]
1147161004543	dimerization interface [polypeptide binding]; other site
1147161004544	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1147161004545	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1147161004546	putative active site pocket [active]
1147161004547	dimerization interface [polypeptide binding]; other site
1147161004548	putative catalytic residue [active]
1147161004549	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1147161004550	TrkA-N domain; Region: TrkA_N; pfam02254
1147161004551	TrkA-C domain; Region: TrkA_C; pfam02080
1147161004552	adenine deaminase; Region: ade; TIGR01178
1147161004553	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147161004554	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1147161004555	active site
1147161004556	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1147161004557	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1147161004558	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1147161004559	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1147161004560	hypothetical protein; Provisional; Region: PRK13667
1147161004561	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1147161004562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161004563	active site
1147161004564	motif I; other site
1147161004565	motif II; other site
1147161004566	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161004567	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1147161004568	active site
1147161004569	catalytic residues [active]
1147161004570	metal binding site [ion binding]; metal-binding site
1147161004571	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1147161004572	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1147161004573	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1147161004574	TPP-binding site [chemical binding]; other site
1147161004575	tetramer interface [polypeptide binding]; other site
1147161004576	heterodimer interface [polypeptide binding]; other site
1147161004577	phosphorylation loop region [posttranslational modification]
1147161004578	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1147161004579	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1147161004580	alpha subunit interface [polypeptide binding]; other site
1147161004581	TPP binding site [chemical binding]; other site
1147161004582	heterodimer interface [polypeptide binding]; other site
1147161004583	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147161004584	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1147161004585	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1147161004586	E3 interaction surface; other site
1147161004587	lipoyl attachment site [posttranslational modification]; other site
1147161004588	e3 binding domain; Region: E3_binding; pfam02817
1147161004589	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1147161004590	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1147161004591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147161004592	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161004593	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1147161004594	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
1147161004595	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1147161004596	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1147161004597	homodimer interface [polypeptide binding]; other site
1147161004598	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161004599	catalytic residue [active]
1147161004600	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1147161004601	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
1147161004602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1147161004603	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1147161004604	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1147161004605	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1147161004606	active site
1147161004607	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1147161004608	Coenzyme A binding pocket [chemical binding]; other site
1147161004609	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1147161004610	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1147161004611	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1147161004612	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1147161004613	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147161004614	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1147161004615	active site
1147161004616	Zn binding site [ion binding]; other site
1147161004617	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161004618	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1147161004619	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161004620	DNA binding residues [nucleotide binding]
1147161004621	Predicted integral membrane protein [Function unknown]; Region: COG5660
1147161004622	Putative zinc-finger; Region: zf-HC2; pfam13490
1147161004623	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1147161004624	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1147161004625	G1 box; other site
1147161004626	putative GEF interaction site [polypeptide binding]; other site
1147161004627	GTP/Mg2+ binding site [chemical binding]; other site
1147161004628	Switch I region; other site
1147161004629	G2 box; other site
1147161004630	G3 box; other site
1147161004631	Switch II region; other site
1147161004632	G4 box; other site
1147161004633	G5 box; other site
1147161004634	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1147161004635	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1147161004636	YlaH-like protein; Region: YlaH; pfam14036
1147161004637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
1147161004638	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1147161004639	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1147161004640	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1147161004641	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1147161004642	putative active site [active]
1147161004643	PhoH-like protein; Region: PhoH; pfam02562
1147161004644	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1147161004645	glutaminase A; Region: Gln_ase; TIGR03814
1147161004646	hypothetical protein; Provisional; Region: PRK13666
1147161004647	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
1147161004648	pyruvate carboxylase; Reviewed; Region: PRK12999
1147161004649	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161004650	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147161004651	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1147161004652	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1147161004653	active site
1147161004654	catalytic residues [active]
1147161004655	metal binding site [ion binding]; metal-binding site
1147161004656	homodimer binding site [polypeptide binding]; other site
1147161004657	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147161004658	carboxyltransferase (CT) interaction site; other site
1147161004659	biotinylation site [posttranslational modification]; other site
1147161004660	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1147161004661	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1147161004662	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1147161004663	UbiA prenyltransferase family; Region: UbiA; pfam01040
1147161004664	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1147161004665	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1147161004666	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
1147161004667	Cytochrome c; Region: Cytochrom_C; pfam00034
1147161004668	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1147161004669	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1147161004670	D-pathway; other site
1147161004671	Putative ubiquinol binding site [chemical binding]; other site
1147161004672	Low-spin heme (heme b) binding site [chemical binding]; other site
1147161004673	Putative water exit pathway; other site
1147161004674	Binuclear center (heme o3/CuB) [ion binding]; other site
1147161004675	K-pathway; other site
1147161004676	Putative proton exit pathway; other site
1147161004677	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1147161004678	Subunit I/III interface [polypeptide binding]; other site
1147161004679	Subunit III/IV interface [polypeptide binding]; other site
1147161004680	cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908
1147161004681	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
1147161004682	YugN-like family; Region: YugN; pfam08868
1147161004683	FOG: CBS domain [General function prediction only]; Region: COG0517
1147161004684	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1147161004685	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1147161004686	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1147161004687	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1147161004688	Putative coat protein; Region: YlbD_coat; pfam14071
1147161004689	YlbE-like protein; Region: YlbE; pfam14003
1147161004690	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
1147161004691	hypothetical protein; Provisional; Region: PRK02886
1147161004692	ylbH leader; BSU6051_1500010
1147161004693	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1147161004694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161004695	S-adenosylmethionine binding site [chemical binding]; other site
1147161004696	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1147161004697	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1147161004698	active site
1147161004699	(T/H)XGH motif; other site
1147161004700	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1147161004701	Nucleoside recognition; Region: Gate; pfam07670
1147161004702	Nucleoside recognition; Region: Gate; pfam07670
1147161004703	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1147161004704	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1147161004705	nucleophile elbow; other site
1147161004706	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1147161004707	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1147161004708	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
1147161004709	protein binding site [polypeptide binding]; other site
1147161004710	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1147161004711	hypothetical protein; Provisional; Region: PRK13670
1147161004712	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1147161004713	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1147161004714	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1147161004715	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1147161004716	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1147161004717	hypothetical protein; Provisional; Region: PRK13688
1147161004718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161004719	Coenzyme A binding pocket [chemical binding]; other site
1147161004720	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
1147161004721	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1147161004722	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1147161004723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1147161004724	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1147161004725	mraZ protein; Region: TIGR00242
1147161004726	MraZ protein; Region: MraZ; pfam02381
1147161004727	MraZ protein; Region: MraZ; pfam02381
1147161004728	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1147161004729	MraW methylase family; Region: Methyltransf_5; pfam01795
1147161004730	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1147161004731	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1147161004732	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161004733	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161004734	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1147161004735	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1147161004736	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1147161004737	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161004738	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161004739	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
1147161004740	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1147161004741	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1147161004742	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147161004743	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147161004744	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1147161004745	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1147161004746	Mg++ binding site [ion binding]; other site
1147161004747	putative catalytic motif [active]
1147161004748	putative substrate binding site [chemical binding]; other site
1147161004749	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1147161004750	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147161004751	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147161004752	stage V sporulation protein E; Region: spoVE; TIGR02615
1147161004753	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1147161004754	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1147161004755	active site
1147161004756	homodimer interface [polypeptide binding]; other site
1147161004757	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1147161004758	FAD binding domain; Region: FAD_binding_4; pfam01565
1147161004759	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1147161004760	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1147161004761	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1147161004762	Cell division protein FtsQ; Region: FtsQ; pfam03799
1147161004763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1147161004764	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1147161004765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1147161004766	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1147161004767	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
1147161004768	cell division protein FtsA; Region: ftsA; TIGR01174
1147161004769	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161004770	nucleotide binding site [chemical binding]; other site
1147161004771	Cell division protein FtsA; Region: FtsA; pfam14450
1147161004772	cell division protein FtsZ; Validated; Region: PRK09330
1147161004773	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1147161004774	nucleotide binding site [chemical binding]; other site
1147161004775	SulA interaction site; other site
1147161004776	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1147161004777	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1147161004778	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
1147161004779	active site
1147161004780	catalytic triad [active]
1147161004781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1147161004782	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1147161004783	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1147161004784	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1147161004785	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1147161004786	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1147161004787	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1147161004788	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161004789	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161004790	DNA binding residues [nucleotide binding]
1147161004791	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1147161004792	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161004793	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147161004794	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161004795	DNA binding residues [nucleotide binding]
1147161004796	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147161004797	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147161004798	Walker A/P-loop; other site
1147161004799	ATP binding site [chemical binding]; other site
1147161004800	Q-loop/lid; other site
1147161004801	ABC transporter signature motif; other site
1147161004802	Walker B; other site
1147161004803	D-loop; other site
1147161004804	H-loop/switch region; other site
1147161004805	acetylornithine deacetylase; Validated; Region: PRK08596
1147161004806	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1147161004807	metal binding site [ion binding]; metal-binding site
1147161004808	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1147161004809	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1147161004810	uncharacterized protein, YfiH family; Region: TIGR00726
1147161004811	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1147161004812	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147161004813	catalytic residue [active]
1147161004814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1147161004815	YGGT family; Region: YGGT; pfam02325
1147161004816	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1147161004817	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161004818	RNA binding surface [nucleotide binding]; other site
1147161004819	DivIVA protein; Region: DivIVA; pfam05103
1147161004820	DivIVA domain; Region: DivI1A_domain; TIGR03544
1147161004821	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1147161004822	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1147161004823	HIGH motif; other site
1147161004824	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1147161004825	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1147161004826	active site
1147161004827	KMSKS motif; other site
1147161004828	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1147161004829	tRNA binding surface [nucleotide binding]; other site
1147161004830	anticodon binding site; other site
1147161004831	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1147161004832	lipoprotein signal peptidase; Region: lspA; TIGR00077
1147161004833	lipoprotein signal peptidase; Provisional; Region: PRK14787
1147161004834	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1147161004835	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161004836	RNA binding surface [nucleotide binding]; other site
1147161004837	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147161004838	active site
1147161004839	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1147161004840	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161004841	active site
1147161004842	uracil-xanthine permease; Region: ncs2; TIGR00801
1147161004843	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1147161004844	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1147161004845	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1147161004846	dihydroorotase; Validated; Region: pyrC; PRK09357
1147161004847	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1147161004848	active site
1147161004849	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1147161004850	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1147161004851	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1147161004852	catalytic site [active]
1147161004853	subunit interface [polypeptide binding]; other site
1147161004854	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1147161004855	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161004856	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147161004857	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1147161004858	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161004859	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147161004860	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1147161004861	IMP binding site; other site
1147161004862	dimer interface [polypeptide binding]; other site
1147161004863	interdomain contacts; other site
1147161004864	partial ornithine binding site; other site
1147161004865	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1147161004866	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1147161004867	FAD binding pocket [chemical binding]; other site
1147161004868	FAD binding motif [chemical binding]; other site
1147161004869	phosphate binding motif [ion binding]; other site
1147161004870	beta-alpha-beta structure motif; other site
1147161004871	NAD binding pocket [chemical binding]; other site
1147161004872	Iron coordination center [ion binding]; other site
1147161004873	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1147161004874	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1147161004875	heterodimer interface [polypeptide binding]; other site
1147161004876	active site
1147161004877	FMN binding site [chemical binding]; other site
1147161004878	homodimer interface [polypeptide binding]; other site
1147161004879	substrate binding site [chemical binding]; other site
1147161004880	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1147161004881	active site
1147161004882	dimer interface [polypeptide binding]; other site
1147161004883	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161004884	active site
1147161004885	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1147161004886	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1147161004887	Active Sites [active]
1147161004888	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1147161004889	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1147161004890	ATP-sulfurylase; Region: ATPS; cd00517
1147161004891	active site
1147161004892	HXXH motif; other site
1147161004893	flexible loop; other site
1147161004894	AAA domain; Region: AAA_33; pfam13671
1147161004895	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1147161004896	ligand-binding site [chemical binding]; other site
1147161004897	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1147161004898	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
1147161004899	active site
1147161004900	SAM binding site [chemical binding]; other site
1147161004901	homodimer interface [polypeptide binding]; other site
1147161004902	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1147161004903	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1147161004904	putative active site [active]
1147161004905	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1147161004906	putative active site [active]
1147161004907	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1147161004908	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1147161004909	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1147161004910	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1147161004911	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1147161004912	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1147161004913	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147161004914	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1147161004915	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161004916	motif II; other site
1147161004917	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1147161004918	TIGR00255 family protein; Region: TIGR00255
1147161004919	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1147161004920	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1147161004921	hypothetical protein; Provisional; Region: PRK04323
1147161004922	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1147161004923	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1147161004924	catalytic site [active]
1147161004925	G-X2-G-X-G-K; other site
1147161004926	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1147161004927	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1147161004928	Flavoprotein; Region: Flavoprotein; pfam02441
1147161004929	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1147161004930	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1147161004931	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161004932	ATP binding site [chemical binding]; other site
1147161004933	putative Mg++ binding site [ion binding]; other site
1147161004934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161004935	nucleotide binding region [chemical binding]; other site
1147161004936	ATP-binding site [chemical binding]; other site
1147161004937	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1147161004938	active site
1147161004939	catalytic residues [active]
1147161004940	metal binding site [ion binding]; metal-binding site
1147161004941	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1147161004942	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1147161004943	putative active site [active]
1147161004944	substrate binding site [chemical binding]; other site
1147161004945	putative cosubstrate binding site; other site
1147161004946	catalytic site [active]
1147161004947	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1147161004948	substrate binding site [chemical binding]; other site
1147161004949	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1147161004950	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1147161004951	putative RNA binding site [nucleotide binding]; other site
1147161004952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161004953	S-adenosylmethionine binding site [chemical binding]; other site
1147161004954	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1147161004955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161004956	FeS/SAM binding site; other site
1147161004957	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1147161004958	Protein phosphatase 2C; Region: PP2C; pfam00481
1147161004959	active site
1147161004960	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1147161004961	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1147161004962	active site
1147161004963	ATP binding site [chemical binding]; other site
1147161004964	substrate binding site [chemical binding]; other site
1147161004965	activation loop (A-loop); other site
1147161004966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1147161004967	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1147161004968	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1147161004969	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1147161004970	GTPase RsgA; Reviewed; Region: PRK00098
1147161004971	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1147161004972	RNA binding site [nucleotide binding]; other site
1147161004973	homodimer interface [polypeptide binding]; other site
1147161004974	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1147161004975	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1147161004976	GTP/Mg2+ binding site [chemical binding]; other site
1147161004977	G4 box; other site
1147161004978	G5 box; other site
1147161004979	G1 box; other site
1147161004980	Switch I region; other site
1147161004981	G2 box; other site
1147161004982	G3 box; other site
1147161004983	Switch II region; other site
1147161004984	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1147161004985	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1147161004986	substrate binding site [chemical binding]; other site
1147161004987	hexamer interface [polypeptide binding]; other site
1147161004988	metal binding site [ion binding]; metal-binding site
1147161004989	Thiamine pyrophosphokinase; Region: TPK; cd07995
1147161004990	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1147161004991	active site
1147161004992	dimerization interface [polypeptide binding]; other site
1147161004993	thiamine binding site [chemical binding]; other site
1147161004994	stage V sporulation protein M; Provisional; Region: spoVM; PRK14741
1147161004995	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1147161004996	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1147161004997	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1147161004998	DAK2 domain; Region: Dak2; pfam02734
1147161004999	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1147161005000	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1147161005001	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1147161005002	putative L-serine binding site [chemical binding]; other site
1147161005003	L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718
1147161005004	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1147161005005	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1147161005006	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1147161005007	generic binding surface II; other site
1147161005008	ssDNA binding site; other site
1147161005009	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161005010	ATP binding site [chemical binding]; other site
1147161005011	putative Mg++ binding site [ion binding]; other site
1147161005012	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161005013	nucleotide binding region [chemical binding]; other site
1147161005014	ATP-binding site [chemical binding]; other site
1147161005015	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1147161005016	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
1147161005017	putative phosphate acyltransferase; Provisional; Region: PRK05331
1147161005018	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1147161005019	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1147161005020	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1147161005021	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1147161005022	NAD(P) binding site [chemical binding]; other site
1147161005023	homotetramer interface [polypeptide binding]; other site
1147161005024	homodimer interface [polypeptide binding]; other site
1147161005025	active site
1147161005026	acyl carrier protein; Provisional; Region: acpP; PRK00982
1147161005027	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1147161005028	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1147161005029	dimerization interface [polypeptide binding]; other site
1147161005030	active site
1147161005031	metal binding site [ion binding]; metal-binding site
1147161005032	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1147161005033	dsRNA binding site [nucleotide binding]; other site
1147161005034	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1147161005035	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1147161005036	Walker A/P-loop; other site
1147161005037	ATP binding site [chemical binding]; other site
1147161005038	Q-loop/lid; other site
1147161005039	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1147161005040	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1147161005041	ABC transporter signature motif; other site
1147161005042	Walker B; other site
1147161005043	D-loop; other site
1147161005044	H-loop/switch region; other site
1147161005045	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1147161005046	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1147161005047	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1147161005048	GTP binding site [chemical binding]; other site
1147161005049	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1147161005050	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1147161005051	putative DNA-binding protein; Validated; Region: PRK00118
1147161005052	signal recognition particle protein; Provisional; Region: PRK10867
1147161005053	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1147161005054	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1147161005055	P loop; other site
1147161005056	GTP binding site [chemical binding]; other site
1147161005057	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1147161005058	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1147161005059	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1147161005060	KH domain; Region: KH_4; pfam13083
1147161005061	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
1147161005062	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1147161005063	RimM N-terminal domain; Region: RimM; pfam01782
1147161005064	PRC-barrel domain; Region: PRC; pfam05239
1147161005065	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1147161005066	L19_leader; BSU6051_1603010
1147161005067	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1147161005068	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1147161005069	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1147161005070	GTP/Mg2+ binding site [chemical binding]; other site
1147161005071	G4 box; other site
1147161005072	G5 box; other site
1147161005073	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1147161005074	G1 box; other site
1147161005075	G1 box; other site
1147161005076	GTP/Mg2+ binding site [chemical binding]; other site
1147161005077	Switch I region; other site
1147161005078	G2 box; other site
1147161005079	G2 box; other site
1147161005080	G3 box; other site
1147161005081	G3 box; other site
1147161005082	Switch II region; other site
1147161005083	Switch II region; other site
1147161005084	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1147161005085	RNA/DNA hybrid binding site [nucleotide binding]; other site
1147161005086	active site
1147161005087	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1147161005088	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1147161005089	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1147161005090	CoA-ligase; Region: Ligase_CoA; pfam00549
1147161005091	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1147161005092	CoA binding domain; Region: CoA_binding; smart00881
1147161005093	CoA-ligase; Region: Ligase_CoA; pfam00549
1147161005094	DNA protecting protein DprA; Region: dprA; TIGR00732
1147161005095	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1147161005096	DNA topoisomerase I; Validated; Region: PRK05582
1147161005097	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1147161005098	active site
1147161005099	interdomain interaction site; other site
1147161005100	putative metal-binding site [ion binding]; other site
1147161005101	nucleotide binding site [chemical binding]; other site
1147161005102	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1147161005103	domain I; other site
1147161005104	DNA binding groove [nucleotide binding]
1147161005105	phosphate binding site [ion binding]; other site
1147161005106	domain II; other site
1147161005107	domain III; other site
1147161005108	nucleotide binding site [chemical binding]; other site
1147161005109	catalytic site [active]
1147161005110	domain IV; other site
1147161005111	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1147161005112	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1147161005113	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1147161005114	Glucose inhibited division protein A; Region: GIDA; pfam01134
1147161005115	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1147161005116	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1147161005117	active site
1147161005118	Int/Topo IB signature motif; other site
1147161005119	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1147161005120	active site
1147161005121	HslU subunit interaction site [polypeptide binding]; other site
1147161005122	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1147161005123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161005124	Walker A motif; other site
1147161005125	ATP binding site [chemical binding]; other site
1147161005126	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1147161005127	Walker B motif; other site
1147161005128	arginine finger; other site
1147161005129	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1147161005130	transcriptional repressor CodY; Validated; Region: PRK04158
1147161005131	CodY GAF-like domain; Region: CodY; pfam06018
1147161005132	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1147161005133	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1147161005134	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1147161005135	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1147161005136	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1147161005137	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1147161005138	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147161005139	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
1147161005140	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
1147161005141	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1147161005142	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1147161005143	flagellar motor switch protein FliG; Region: fliG; TIGR00207
1147161005144	MgtE intracellular N domain; Region: MgtE_N; smart00924
1147161005145	FliG C-terminal domain; Region: FliG_C; pfam01706
1147161005146	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
1147161005147	Flagellar assembly protein FliH; Region: FliH; pfam02108
1147161005148	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
1147161005149	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1147161005150	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1147161005151	Walker A motif/ATP binding site; other site
1147161005152	Walker B motif; other site
1147161005153	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
1147161005154	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
1147161005155	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1147161005156	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
1147161005157	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1147161005158	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
1147161005159	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1147161005160	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
1147161005161	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1147161005162	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147161005163	Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582
1147161005164	Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580
1147161005165	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
1147161005166	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1147161005167	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1147161005168	flagellar motor switch protein; Validated; Region: PRK08119
1147161005169	CheC-like family; Region: CheC; pfam04509
1147161005170	CheC-like family; Region: CheC; pfam04509
1147161005171	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1147161005172	Response regulator receiver domain; Region: Response_reg; pfam00072
1147161005173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161005174	active site
1147161005175	phosphorylation site [posttranslational modification]
1147161005176	intermolecular recognition site; other site
1147161005177	dimerization interface [polypeptide binding]; other site
1147161005178	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
1147161005179	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1147161005180	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1147161005181	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1147161005182	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1147161005183	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1147161005184	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1147161005185	FHIPEP family; Region: FHIPEP; pfam00771
1147161005186	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1147161005187	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147161005188	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1147161005189	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1147161005190	P-loop; other site
1147161005191	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1147161005192	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1147161005193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161005194	active site
1147161005195	phosphorylation site [posttranslational modification]
1147161005196	intermolecular recognition site; other site
1147161005197	dimerization interface [polypeptide binding]; other site
1147161005198	CheB methylesterase; Region: CheB_methylest; pfam01339
1147161005199	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1147161005200	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1147161005201	putative binding surface; other site
1147161005202	active site
1147161005203	P2 response regulator binding domain; Region: P2; pfam07194
1147161005204	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1147161005205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161005206	ATP binding site [chemical binding]; other site
1147161005207	Mg2+ binding site [ion binding]; other site
1147161005208	G-X-G motif; other site
1147161005209	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1147161005210	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1147161005211	putative CheA interaction surface; other site
1147161005212	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1147161005213	CheC-like family; Region: CheC; pfam04509
1147161005214	CheC-like family; Region: CheC; pfam04509
1147161005215	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
1147161005216	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
1147161005217	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161005218	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147161005219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161005220	DNA binding residues [nucleotide binding]
1147161005221	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1147161005222	rRNA interaction site [nucleotide binding]; other site
1147161005223	S8 interaction site; other site
1147161005224	putative laminin-1 binding site; other site
1147161005225	elongation factor Ts; Provisional; Region: tsf; PRK09377
1147161005226	UBA/TS-N domain; Region: UBA; pfam00627
1147161005227	Elongation factor TS; Region: EF_TS; pfam00889
1147161005228	Elongation factor TS; Region: EF_TS; pfam00889
1147161005229	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1147161005230	putative nucleotide binding site [chemical binding]; other site
1147161005231	uridine monophosphate binding site [chemical binding]; other site
1147161005232	homohexameric interface [polypeptide binding]; other site
1147161005233	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1147161005234	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1147161005235	hinge region; other site
1147161005236	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1147161005237	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1147161005238	catalytic residue [active]
1147161005239	putative FPP diphosphate  binding site; other site
1147161005240	putative FPP binding hydrophobic cleft; other site
1147161005241	dimer interface [polypeptide binding]; other site
1147161005242	putative IPP diphosphate binding site; other site
1147161005243	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1147161005244	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1147161005245	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1147161005246	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1147161005247	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1147161005248	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1147161005249	RIP metalloprotease RseP; Region: TIGR00054
1147161005250	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1147161005251	active site
1147161005252	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1147161005253	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1147161005254	protein binding site [polypeptide binding]; other site
1147161005255	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1147161005256	putative substrate binding region [chemical binding]; other site
1147161005257	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1147161005258	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1147161005259	dimer interface [polypeptide binding]; other site
1147161005260	motif 1; other site
1147161005261	active site
1147161005262	motif 2; other site
1147161005263	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1147161005264	putative deacylase active site [active]
1147161005265	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1147161005266	active site
1147161005267	motif 3; other site
1147161005268	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1147161005269	anticodon binding site; other site
1147161005270	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1147161005271	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1147161005272	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1147161005273	generic binding surface II; other site
1147161005274	generic binding surface I; other site
1147161005275	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1147161005276	active site
1147161005277	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1147161005278	active site
1147161005279	catalytic site [active]
1147161005280	substrate binding site [chemical binding]; other site
1147161005281	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1147161005282	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1147161005283	Sm and related proteins; Region: Sm_like; cl00259
1147161005284	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1147161005285	putative oligomer interface [polypeptide binding]; other site
1147161005286	putative RNA binding site [nucleotide binding]; other site
1147161005287	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1147161005288	NusA N-terminal domain; Region: NusA_N; pfam08529
1147161005289	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1147161005290	RNA binding site [nucleotide binding]; other site
1147161005291	homodimer interface [polypeptide binding]; other site
1147161005292	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1147161005293	G-X-X-G motif; other site
1147161005294	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1147161005295	G-X-X-G motif; other site
1147161005296	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1147161005297	putative RNA binding cleft [nucleotide binding]; other site
1147161005298	hypothetical protein; Provisional; Region: PRK07714
1147161005299	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1147161005300	translation initiation factor IF-2; Region: IF-2; TIGR00487
1147161005301	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1147161005302	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1147161005303	G1 box; other site
1147161005304	putative GEF interaction site [polypeptide binding]; other site
1147161005305	GTP/Mg2+ binding site [chemical binding]; other site
1147161005306	Switch I region; other site
1147161005307	G2 box; other site
1147161005308	G3 box; other site
1147161005309	Switch II region; other site
1147161005310	G4 box; other site
1147161005311	G5 box; other site
1147161005312	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1147161005313	Translation-initiation factor 2; Region: IF-2; pfam11987
1147161005314	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1147161005315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
1147161005316	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1147161005317	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1147161005318	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1147161005319	RNA binding site [nucleotide binding]; other site
1147161005320	active site
1147161005321	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1147161005322	riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083
1147161005323	active site
1147161005324	Riboflavin kinase; Region: Flavokinase; smart00904
1147161005325	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1147161005326	16S/18S rRNA binding site [nucleotide binding]; other site
1147161005327	S13e-L30e interaction site [polypeptide binding]; other site
1147161005328	25S rRNA binding site [nucleotide binding]; other site
1147161005329	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1147161005330	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1147161005331	RNase E interface [polypeptide binding]; other site
1147161005332	trimer interface [polypeptide binding]; other site
1147161005333	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1147161005334	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1147161005335	RNase E interface [polypeptide binding]; other site
1147161005336	trimer interface [polypeptide binding]; other site
1147161005337	active site
1147161005338	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1147161005339	putative nucleic acid binding region [nucleotide binding]; other site
1147161005340	G-X-X-G motif; other site
1147161005341	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1147161005342	RNA binding site [nucleotide binding]; other site
1147161005343	domain interface; other site
1147161005344	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
1147161005345	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1147161005346	NodB motif; other site
1147161005347	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1147161005348	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1147161005349	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1147161005350	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1147161005351	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1147161005352	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1147161005353	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
1147161005354	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1147161005355	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1147161005356	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1147161005357	aspartate kinase I; Reviewed; Region: PRK08210
1147161005358	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
1147161005359	putative catalytic residues [active]
1147161005360	putative nucleotide binding site [chemical binding]; other site
1147161005361	putative aspartate binding site [chemical binding]; other site
1147161005362	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1147161005363	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
1147161005364	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1147161005365	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1147161005366	dimer interface [polypeptide binding]; other site
1147161005367	active site
1147161005368	catalytic residue [active]
1147161005369	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1147161005370	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161005371	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1147161005372	Clp protease; Region: CLP_protease; pfam00574
1147161005373	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1147161005374	active site
1147161005375	YlzJ-like protein; Region: YlzJ; pfam14035
1147161005376	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1147161005377	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1147161005378	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147161005379	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1147161005380	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147161005381	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161005382	DNA-binding site [nucleotide binding]; DNA binding site
1147161005383	UTRA domain; Region: UTRA; pfam07702
1147161005384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161005385	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161005386	putative substrate translocation pore; other site
1147161005387	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1147161005388	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1147161005389	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1147161005390	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1147161005391	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1147161005392	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1147161005393	classical (c) SDRs; Region: SDR_c; cd05233
1147161005394	NAD(P) binding site [chemical binding]; other site
1147161005395	active site
1147161005396	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1147161005397	ACT domain; Region: ACT; pfam01842
1147161005398	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1147161005399	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1147161005400	Helix-turn-helix domain; Region: HTH_25; pfam13413
1147161005401	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1147161005402	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1147161005403	competence damage-inducible protein A; Provisional; Region: PRK00549
1147161005404	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1147161005405	putative MPT binding site; other site
1147161005406	competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199
1147161005407	recombinase A; Provisional; Region: recA; PRK09354
1147161005408	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1147161005409	hexamer interface [polypeptide binding]; other site
1147161005410	Walker A motif; other site
1147161005411	ATP binding site [chemical binding]; other site
1147161005412	Walker B motif; other site
1147161005413	Beta-lactamase; Region: Beta-lactamase; pfam00144
1147161005414	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1147161005415	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
1147161005416	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1147161005417	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161005418	Zn2+ binding site [ion binding]; other site
1147161005419	Mg2+ binding site [ion binding]; other site
1147161005420	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1147161005421	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161005422	putative active site [active]
1147161005423	metal binding site [ion binding]; metal-binding site
1147161005424	homodimer binding site [polypeptide binding]; other site
1147161005425	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1147161005426	Threonine dehydrogenase; Region: TDH; cd05281
1147161005427	L-threonine 3-dehydrogenase; Region: tdh; TIGR00692
1147161005428	structural Zn binding site [ion binding]; other site
1147161005429	catalytic Zn binding site [ion binding]; other site
1147161005430	tetramer interface [polypeptide binding]; other site
1147161005431	NADP binding site [chemical binding]; other site
1147161005432	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1147161005433	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1147161005434	substrate-cofactor binding pocket; other site
1147161005435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161005436	catalytic residue [active]
1147161005437	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1147161005438	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1147161005439	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161005440	FeS/SAM binding site; other site
1147161005441	TRAM domain; Region: TRAM; pfam01938
1147161005442	Predicted membrane protein [Function unknown]; Region: COG4550
1147161005443	Outer spore coat protein E (CotE); Region: CotE; pfam10628
1147161005444	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1147161005445	MutS domain I; Region: MutS_I; pfam01624
1147161005446	MutS domain II; Region: MutS_II; pfam05188
1147161005447	MutS domain III; Region: MutS_III; pfam05192
1147161005448	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1147161005449	Walker A/P-loop; other site
1147161005450	ATP binding site [chemical binding]; other site
1147161005451	Q-loop/lid; other site
1147161005452	ABC transporter signature motif; other site
1147161005453	Walker B; other site
1147161005454	D-loop; other site
1147161005455	H-loop/switch region; other site
1147161005456	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1147161005457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161005458	ATP binding site [chemical binding]; other site
1147161005459	Mg2+ binding site [ion binding]; other site
1147161005460	G-X-G motif; other site
1147161005461	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1147161005462	ATP binding site [chemical binding]; other site
1147161005463	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1147161005464	Regulatory protein YrvL; Region: YrvL; pfam14184
1147161005465	transcriptional regulator BetI; Validated; Region: PRK00767
1147161005466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161005467	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1147161005468	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1147161005469	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1147161005470	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1147161005471	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1147161005472	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1147161005473	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1147161005474	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1147161005475	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
1147161005476	FMN binding site [chemical binding]; other site
1147161005477	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1147161005478	substrate binding site [chemical binding]; other site
1147161005479	putative catalytic residue [active]
1147161005480	acyl carrier protein; Validated; Region: PRK07117
1147161005481	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
1147161005482	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1147161005483	dimer interface [polypeptide binding]; other site
1147161005484	active site
1147161005485	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
1147161005486	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1147161005487	dimer interface [polypeptide binding]; other site
1147161005488	active site
1147161005489	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161005490	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1147161005491	substrate binding site [chemical binding]; other site
1147161005492	oxyanion hole (OAH) forming residues; other site
1147161005493	trimer interface [polypeptide binding]; other site
1147161005494	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1147161005495	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161005496	substrate binding site [chemical binding]; other site
1147161005497	oxyanion hole (OAH) forming residues; other site
1147161005498	trimer interface [polypeptide binding]; other site
1147161005499	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
1147161005500	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1147161005501	acyl-activating enzyme (AAE) consensus motif; other site
1147161005502	putative AMP binding site [chemical binding]; other site
1147161005503	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005504	Condensation domain; Region: Condensation; pfam00668
1147161005505	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005506	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005507	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1147161005508	acyl-activating enzyme (AAE) consensus motif; other site
1147161005509	AMP binding site [chemical binding]; other site
1147161005510	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005511	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005512	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005513	active site
1147161005514	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005515	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005516	KR domain; Region: KR; pfam08659
1147161005517	putative NADP binding site [chemical binding]; other site
1147161005518	active site
1147161005519	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005520	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005521	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005522	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005523	active site
1147161005524	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005525	putative NADP binding site [chemical binding]; other site
1147161005526	active site
1147161005527	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005528	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005529	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1147161005530	active site
1147161005531	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005532	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005533	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005534	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005535	active site
1147161005536	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005537	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005538	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1147161005539	putative NADP binding site [chemical binding]; other site
1147161005540	active site
1147161005541	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005542	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005543	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1147161005544	active site
1147161005545	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005546	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005547	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005548	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005549	active site
1147161005550	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161005551	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005552	putative NADP binding site [chemical binding]; other site
1147161005553	active site
1147161005554	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005555	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005556	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1147161005557	active site
1147161005558	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005559	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005560	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005561	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005562	active site
1147161005563	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005564	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005565	putative NADP binding site [chemical binding]; other site
1147161005566	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1147161005567	active site
1147161005568	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1147161005569	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005570	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005571	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005572	active site
1147161005573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161005574	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005575	putative NADP binding site [chemical binding]; other site
1147161005576	active site
1147161005577	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005578	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005579	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1147161005580	active site
1147161005581	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005582	Condensation domain; Region: Condensation; pfam00668
1147161005583	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005584	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005585	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005586	acyl-activating enzyme (AAE) consensus motif; other site
1147161005587	AMP binding site [chemical binding]; other site
1147161005588	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005589	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005590	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005591	active site
1147161005592	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005593	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005594	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1147161005595	putative NADP binding site [chemical binding]; other site
1147161005596	active site
1147161005597	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005598	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005599	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005600	active site
1147161005601	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005602	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005603	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1147161005604	putative NADP binding site [chemical binding]; other site
1147161005605	active site
1147161005606	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005607	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005608	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005609	active site
1147161005610	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1147161005611	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1147161005612	putative NADP binding site [chemical binding]; other site
1147161005613	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1147161005614	active site
1147161005615	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1147161005616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161005617	S-adenosylmethionine binding site [chemical binding]; other site
1147161005618	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005619	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005620	active site
1147161005621	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1147161005622	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1147161005623	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1147161005624	active site
1147161005625	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1147161005626	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161005627	Cytochrome P450; Region: p450; cl12078
1147161005628	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161005629	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1147161005630	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
1147161005631	active site
1147161005632	catalytic triad [active]
1147161005633	Phage-related replication protein [General function prediction only]; Region: COG4195
1147161005634	peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563
1147161005635	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1147161005636	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1147161005637	YmaF family; Region: YmaF; pfam12788
1147161005638	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1147161005639	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1147161005640	bacterial Hfq-like; Region: Hfq; cd01716
1147161005641	hexamer interface [polypeptide binding]; other site
1147161005642	Sm1 motif; other site
1147161005643	RNA binding site [nucleotide binding]; other site
1147161005644	Sm2 motif; other site
1147161005645	YmzC-like protein; Region: YmzC; pfam14157
1147161005646	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1147161005647	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1147161005648	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1147161005649	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1147161005650	active site
1147161005651	dimer interface [polypeptide binding]; other site
1147161005652	catalytic residues [active]
1147161005653	effector binding site; other site
1147161005654	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1147161005655	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1147161005656	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1147161005657	dimer interface [polypeptide binding]; other site
1147161005658	putative radical transfer pathway; other site
1147161005659	diiron center [ion binding]; other site
1147161005660	tyrosyl radical; other site
1147161005661	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1147161005662	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1147161005663	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1147161005664	active site
1147161005665	metal binding site [ion binding]; metal-binding site
1147161005666	Sporulation related domain; Region: SPOR; pfam05036
1147161005667	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1147161005668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161005669	Walker A motif; other site
1147161005670	ATP binding site [chemical binding]; other site
1147161005671	Walker B motif; other site
1147161005672	arginine finger; other site
1147161005673	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1147161005674	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1147161005675	HflX GTPase family; Region: HflX; cd01878
1147161005676	G1 box; other site
1147161005677	GTP/Mg2+ binding site [chemical binding]; other site
1147161005678	Switch I region; other site
1147161005679	G2 box; other site
1147161005680	G3 box; other site
1147161005681	Switch II region; other site
1147161005682	G4 box; other site
1147161005683	G5 box; other site
1147161005684	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1147161005685	Aluminium resistance protein; Region: Alum_res; pfam06838
1147161005686	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1147161005687	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1147161005688	DNA binding residues [nucleotide binding]
1147161005689	putative dimer interface [polypeptide binding]; other site
1147161005690	glutamine synthetase, type I; Region: GlnA; TIGR00653
1147161005691	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1147161005692	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1147161005693	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
1147161005694	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161005695	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161005696	Coenzyme A binding pocket [chemical binding]; other site
1147161005697	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
1147161005698	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1147161005699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161005700	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1147161005701	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1147161005702	inhibitor binding site; inhibition site
1147161005703	active site
1147161005704	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1147161005705	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161005706	nucleotide binding site [chemical binding]; other site
1147161005707	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1147161005708	xylose isomerase; Provisional; Region: PRK05474
1147161005709	xylose isomerase; Region: xylose_isom_A; TIGR02630
1147161005710	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1147161005711	N- and C-terminal domain interface [polypeptide binding]; other site
1147161005712	D-xylulose kinase; Region: XylB; TIGR01312
1147161005713	active site
1147161005714	MgATP binding site [chemical binding]; other site
1147161005715	catalytic site [active]
1147161005716	metal binding site [ion binding]; metal-binding site
1147161005717	xylulose binding site [chemical binding]; other site
1147161005718	homodimer interface [polypeptide binding]; other site
1147161005719	Staphylococcal nuclease homologues; Region: SNc; smart00318
1147161005720	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1147161005721	Catalytic site; other site
1147161005722	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161005723	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1147161005724	putative substrate translocation pore; other site
1147161005725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161005726	alanine racemase; Region: alr; TIGR00492
1147161005727	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1147161005728	active site
1147161005729	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147161005730	dimer interface [polypeptide binding]; other site
1147161005731	substrate binding site [chemical binding]; other site
1147161005732	catalytic residues [active]
1147161005733	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
1147161005734	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1147161005735	trimer interface [polypeptide binding]; other site
1147161005736	active site
1147161005737	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1147161005738	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1147161005739	dimerization interface [polypeptide binding]; other site
1147161005740	active site
1147161005741	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
1147161005742	putative binding site; other site
1147161005743	putative dimer interface [polypeptide binding]; other site
1147161005744	YoqO-like protein; Region: YoqO; pfam14037
1147161005745	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1147161005746	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1147161005747	putative hydrophobic ligand binding site [chemical binding]; other site
1147161005748	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147161005749	Spore germination protein; Region: Spore_permease; pfam03845
1147161005750	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147161005751	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147161005752	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1147161005753	YndJ-like protein; Region: YndJ; pfam14158
1147161005754	Phage-related replication protein [General function prediction only]; Region: COG4195
1147161005755	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1147161005756	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1147161005757	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
1147161005758	putative active site [active]
1147161005759	putative Mg binding site [ion binding]; other site
1147161005760	LexA repressor; Validated; Region: PRK00215
1147161005761	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161005762	putative DNA binding site [nucleotide binding]; other site
1147161005763	putative Zn2+ binding site [ion binding]; other site
1147161005764	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1147161005765	Catalytic site [active]
1147161005766	cell division suppressor protein YneA; Provisional; Region: PRK14125
1147161005767	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161005768	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147161005769	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1147161005770	catalytic residues [active]
1147161005771	catalytic nucleophile [active]
1147161005772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
1147161005773	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1147161005774	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1147161005775	TPP-binding site [chemical binding]; other site
1147161005776	dimer interface [polypeptide binding]; other site
1147161005777	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1147161005778	PYR/PP interface [polypeptide binding]; other site
1147161005779	dimer interface [polypeptide binding]; other site
1147161005780	TPP binding site [chemical binding]; other site
1147161005781	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147161005782	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
1147161005783	hypothetical protein; Provisional; Region: PRK01844
1147161005784	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1147161005785	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1147161005786	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1147161005787	Response regulator receiver domain; Region: Response_reg; pfam00072
1147161005788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161005789	active site
1147161005790	phosphorylation site [posttranslational modification]
1147161005791	intermolecular recognition site; other site
1147161005792	dimerization interface [polypeptide binding]; other site
1147161005793	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1147161005794	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
1147161005795	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1147161005796	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1147161005797	putative dimer interface [polypeptide binding]; other site
1147161005798	acid-soluble spore protein P; Provisional; Region: sspP; PRK09399
1147161005799	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
1147161005800	aconitate hydratase; Validated; Region: PRK09277
1147161005801	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1147161005802	substrate binding site [chemical binding]; other site
1147161005803	ligand binding site [chemical binding]; other site
1147161005804	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1147161005805	substrate binding site [chemical binding]; other site
1147161005806	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1147161005807	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161005808	catalytic residues [active]
1147161005809	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1147161005810	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
1147161005811	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
1147161005812	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1147161005813	active site
1147161005814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1147161005815	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1147161005816	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1147161005817	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
1147161005818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161005819	ATP binding site [chemical binding]; other site
1147161005820	Mg2+ binding site [ion binding]; other site
1147161005821	G-X-G motif; other site
1147161005822	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1147161005823	anchoring element; other site
1147161005824	dimer interface [polypeptide binding]; other site
1147161005825	ATP binding site [chemical binding]; other site
1147161005826	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1147161005827	active site
1147161005828	putative metal-binding site [ion binding]; other site
1147161005829	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1147161005830	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1147161005831	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1147161005832	CAP-like domain; other site
1147161005833	active site
1147161005834	primary dimer interface [polypeptide binding]; other site
1147161005835	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161005836	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161005837	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161005838	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147161005839	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1147161005840	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1147161005841	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1147161005842	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1147161005843	Cellulose binding domain; Region: CBM_3; pfam00942
1147161005844	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
1147161005845	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1147161005846	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
1147161005847	substrate binding site [chemical binding]; other site
1147161005848	active site
1147161005849	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1147161005850	metal binding site [ion binding]; metal-binding site
1147161005851	ligand binding site [chemical binding]; other site
1147161005852	Predicted membrane protein [Function unknown]; Region: COG2246
1147161005853	GtrA-like protein; Region: GtrA; pfam04138
1147161005854	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1147161005855	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1147161005856	active site
1147161005857	tetramer interface; other site
1147161005858	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1147161005859	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1147161005860	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
1147161005861	DHH family; Region: DHH; pfam01368
1147161005862	DHHA1 domain; Region: DHHA1; pfam02272
1147161005863	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1147161005864	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1147161005865	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1147161005866	enoyl-CoA hydratase; Provisional; Region: PRK07657
1147161005867	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161005868	substrate binding site [chemical binding]; other site
1147161005869	oxyanion hole (OAH) forming residues; other site
1147161005870	trimer interface [polypeptide binding]; other site
1147161005871	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1147161005872	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1147161005873	active site
1147161005874	catalytic residues [active]
1147161005875	metal binding site [ion binding]; metal-binding site
1147161005876	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147161005877	carboxyltransferase (CT) interaction site; other site
1147161005878	biotinylation site [posttranslational modification]; other site
1147161005879	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
1147161005880	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161005881	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147161005882	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1147161005883	AMP-binding domain protein; Validated; Region: PRK08315
1147161005884	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147161005885	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1147161005886	acyl-activating enzyme (AAE) consensus motif; other site
1147161005887	putative AMP binding site [chemical binding]; other site
1147161005888	putative active site [active]
1147161005889	putative CoA binding site [chemical binding]; other site
1147161005890	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1147161005891	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1147161005892	active site
1147161005893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1147161005894	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1147161005895	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
1147161005896	Condensation domain; Region: Condensation; pfam00668
1147161005897	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005898	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161005899	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1147161005900	acyl-activating enzyme (AAE) consensus motif; other site
1147161005901	AMP binding site [chemical binding]; other site
1147161005902	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005903	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1147161005904	Condensation domain; Region: Condensation; pfam00668
1147161005905	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005906	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005907	acyl-activating enzyme (AAE) consensus motif; other site
1147161005908	AMP binding site [chemical binding]; other site
1147161005909	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005910	Condensation domain; Region: Condensation; pfam00668
1147161005911	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005912	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005913	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005914	acyl-activating enzyme (AAE) consensus motif; other site
1147161005915	AMP binding site [chemical binding]; other site
1147161005916	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005917	Condensation domain; Region: Condensation; pfam00668
1147161005918	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005919	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005920	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005921	acyl-activating enzyme (AAE) consensus motif; other site
1147161005922	AMP binding site [chemical binding]; other site
1147161005923	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005924	Condensation domain; Region: Condensation; pfam00668
1147161005925	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161005926	Condensation domain; Region: Condensation; pfam00668
1147161005927	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005928	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005929	acyl-activating enzyme (AAE) consensus motif; other site
1147161005930	AMP binding site [chemical binding]; other site
1147161005931	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005932	Condensation domain; Region: Condensation; pfam00668
1147161005933	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005934	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005935	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1147161005936	acyl-activating enzyme (AAE) consensus motif; other site
1147161005937	AMP binding site [chemical binding]; other site
1147161005938	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005939	Condensation domain; Region: Condensation; pfam00668
1147161005940	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161005941	Condensation domain; Region: Condensation; pfam00668
1147161005942	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005943	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005944	acyl-activating enzyme (AAE) consensus motif; other site
1147161005945	AMP binding site [chemical binding]; other site
1147161005946	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005947	Condensation domain; Region: Condensation; pfam00668
1147161005948	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005949	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005950	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005951	acyl-activating enzyme (AAE) consensus motif; other site
1147161005952	AMP binding site [chemical binding]; other site
1147161005953	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005954	Condensation domain; Region: Condensation; pfam00668
1147161005955	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005956	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161005957	Condensation domain; Region: Condensation; pfam00668
1147161005958	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005959	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005960	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005961	acyl-activating enzyme (AAE) consensus motif; other site
1147161005962	AMP binding site [chemical binding]; other site
1147161005963	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005964	Condensation domain; Region: Condensation; pfam00668
1147161005965	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005966	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161005967	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161005968	acyl-activating enzyme (AAE) consensus motif; other site
1147161005969	AMP binding site [chemical binding]; other site
1147161005970	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161005971	Condensation domain; Region: Condensation; pfam00668
1147161005972	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161005973	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1147161005974	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
1147161005975	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1147161005976	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1147161005977	active site
1147161005978	catalytic residues [active]
1147161005979	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1147161005980	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1147161005981	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1147161005982	Int/Topo IB signature motif; other site
1147161005983	Helix-turn-helix domain; Region: HTH_17; cl17695
1147161005984	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1147161005985	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1147161005986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161005987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161005988	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1147161005989	putative dimerization interface [polypeptide binding]; other site
1147161005990	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1147161005991	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1147161005992	NAD(P) binding site [chemical binding]; other site
1147161005993	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
1147161005994	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147161005995	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1147161005996	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1147161005997	active site
1147161005998	dimer interface [polypeptide binding]; other site
1147161005999	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1147161006000	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1147161006001	active site
1147161006002	FMN binding site [chemical binding]; other site
1147161006003	substrate binding site [chemical binding]; other site
1147161006004	3Fe-4S cluster binding site [ion binding]; other site
1147161006005	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1147161006006	domain interface; other site
1147161006007	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161006008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161006009	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1147161006010	putative dimerization interface [polypeptide binding]; other site
1147161006011	gamma-glutamyl kinase; Provisional; Region: PRK13402
1147161006012	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1147161006013	nucleotide binding site [chemical binding]; other site
1147161006014	homotetrameric interface [polypeptide binding]; other site
1147161006015	putative phosphate binding site [ion binding]; other site
1147161006016	putative allosteric binding site; other site
1147161006017	PUA domain; Region: PUA; pfam01472
1147161006018	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1147161006019	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1147161006020	Replication terminator protein; Region: RTP; pfam02334
1147161006021	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
1147161006022	classical (c) SDRs; Region: SDR_c; cd05233
1147161006023	NAD(P) binding site [chemical binding]; other site
1147161006024	active site
1147161006025	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1147161006026	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161006027	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147161006028	polyol permease family; Region: 2A0118; TIGR00897
1147161006029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161006030	putative substrate translocation pore; other site
1147161006031	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1147161006032	Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798
1147161006033	putative N- and C-terminal domain interface [polypeptide binding]; other site
1147161006034	putative active site [active]
1147161006035	putative MgATP binding site [chemical binding]; other site
1147161006036	catalytic site [active]
1147161006037	metal binding site [ion binding]; metal-binding site
1147161006038	carbohydrate binding site [chemical binding]; other site
1147161006039	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1147161006040	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1147161006041	putative ligand binding site [chemical binding]; other site
1147161006042	putative NAD binding site [chemical binding]; other site
1147161006043	catalytic site [active]
1147161006044	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1147161006045	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1147161006046	putative [4Fe-4S] binding site [ion binding]; other site
1147161006047	putative molybdopterin cofactor binding site [chemical binding]; other site
1147161006048	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1147161006049	putative molybdopterin cofactor binding site; other site
1147161006050	Protein of unknown function (DUF4025); Region: DUF4025; pfam13217
1147161006051	CHASE3 domain; Region: CHASE3; cl05000
1147161006052	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161006053	dimerization interface [polypeptide binding]; other site
1147161006054	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147161006055	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161006056	dimer interface [polypeptide binding]; other site
1147161006057	putative CheW interface [polypeptide binding]; other site
1147161006058	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1147161006059	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1147161006060	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
1147161006061	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1147161006062	Predicted membrane protein [Function unknown]; Region: COG3619
1147161006063	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1147161006064	Amb_all domain; Region: Amb_all; smart00656
1147161006065	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1147161006066	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
1147161006067	Cupin; Region: Cupin_1; smart00835
1147161006068	Cupin; Region: Cupin_1; smart00835
1147161006069	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1147161006070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161006071	Coenzyme A binding pocket [chemical binding]; other site
1147161006072	YoaP-like; Region: YoaP; pfam14268
1147161006073	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
1147161006074	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1147161006075	VanW like protein; Region: VanW; pfam04294
1147161006076	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1147161006077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161006078	salt bridge; other site
1147161006079	non-specific DNA binding site [nucleotide binding]; other site
1147161006080	sequence-specific DNA binding site [nucleotide binding]; other site
1147161006081	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
1147161006082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161006083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161006084	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161006085	dimerization interface [polypeptide binding]; other site
1147161006086	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161006087	EamA-like transporter family; Region: EamA; pfam00892
1147161006088	EamA-like transporter family; Region: EamA; pfam00892
1147161006089	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1147161006090	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1147161006091	conserved cys residue [active]
1147161006092	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1147161006093	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1147161006094	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
1147161006095	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1147161006096	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1147161006097	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1147161006098	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
1147161006099	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1147161006100	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161006101	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161006102	non-specific DNA binding site [nucleotide binding]; other site
1147161006103	salt bridge; other site
1147161006104	sequence-specific DNA binding site [nucleotide binding]; other site
1147161006105	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1147161006106	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
1147161006107	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1147161006108	putative active site [active]
1147161006109	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161006110	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161006111	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161006112	TPR motif; other site
1147161006113	binding surface
1147161006114	Y-family of DNA polymerases; Region: PolY; cl12025
1147161006115	DNA binding site [nucleotide binding]
1147161006116	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1147161006117	Y-family of DNA polymerases; Region: PolY; cl12025
1147161006118	active site
1147161006119	YolD-like protein; Region: YolD; pfam08863
1147161006120	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1147161006121	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1147161006122	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
1147161006123	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1147161006124	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1147161006125	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147161006126	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1147161006127	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
1147161006128	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1147161006129	dimer interface [polypeptide binding]; other site
1147161006130	putative tRNA-binding site [nucleotide binding]; other site
1147161006131	Cupin domain; Region: Cupin_2; pfam07883
1147161006132	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161006133	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161006134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161006135	Coenzyme A binding pocket [chemical binding]; other site
1147161006136	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161006137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161006138	WHG domain; Region: WHG; pfam13305
1147161006139	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161006140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1147161006141	Predicted transcriptional regulator [Transcription]; Region: COG2378
1147161006142	HTH domain; Region: HTH_11; pfam08279
1147161006143	WYL domain; Region: WYL; pfam13280
1147161006144	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161006145	dimerization interface [polypeptide binding]; other site
1147161006146	putative DNA binding site [nucleotide binding]; other site
1147161006147	putative Zn2+ binding site [ion binding]; other site
1147161006148	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1147161006149	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147161006150	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147161006151	catalytic residue [active]
1147161006152	Predicted membrane protein [Function unknown]; Region: COG2322
1147161006153	Protein required for attachment to host cells; Region: Host_attach; cl02398
1147161006154	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147161006155	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1147161006156	putative dimer interface [polypeptide binding]; other site
1147161006157	catalytic triad [active]
1147161006158	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1147161006159	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1147161006160	putative di-iron ligands [ion binding]; other site
1147161006161	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161006162	Histidine kinase; Region: HisKA_3; pfam07730
1147161006163	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1147161006164	ATP binding site [chemical binding]; other site
1147161006165	Mg2+ binding site [ion binding]; other site
1147161006166	G-X-G motif; other site
1147161006167	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161006168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161006169	active site
1147161006170	phosphorylation site [posttranslational modification]
1147161006171	intermolecular recognition site; other site
1147161006172	dimerization interface [polypeptide binding]; other site
1147161006173	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161006174	DNA binding residues [nucleotide binding]
1147161006175	dimerization interface [polypeptide binding]; other site
1147161006176	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006177	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1147161006179	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1147161006180	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161006181	ATP binding site [chemical binding]; other site
1147161006182	putative Mg++ binding site [ion binding]; other site
1147161006183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161006184	nucleotide binding region [chemical binding]; other site
1147161006185	ATP-binding site [chemical binding]; other site
1147161006186	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1147161006187	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1147161006188	azoreductase; Provisional; Region: PRK13556
1147161006189	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1147161006190	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1147161006191	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1147161006192	putative dimer interface [polypeptide binding]; other site
1147161006193	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1147161006194	pentamer interface [polypeptide binding]; other site
1147161006195	dodecaamer interface [polypeptide binding]; other site
1147161006196	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1147161006197	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1147161006198	NAD(P) binding site [chemical binding]; other site
1147161006199	catalytic residues [active]
1147161006200	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1147161006201	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1147161006202	Active site cavity [active]
1147161006203	Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657
1147161006204	catalytic acid [active]
1147161006205	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1147161006206	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1147161006207	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1147161006208	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1147161006209	Na2 binding site [ion binding]; other site
1147161006210	putative substrate binding site 1 [chemical binding]; other site
1147161006211	Na binding site 1 [ion binding]; other site
1147161006212	putative substrate binding site 2 [chemical binding]; other site
1147161006213	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1147161006214	Sodium Bile acid symporter family; Region: SBF; pfam01758
1147161006215	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1147161006216	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1147161006217	E3 interaction surface; other site
1147161006218	lipoyl attachment site [posttranslational modification]; other site
1147161006219	e3 binding domain; Region: E3_binding; pfam02817
1147161006220	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1147161006221	2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239
1147161006222	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1147161006223	TPP-binding site [chemical binding]; other site
1147161006224	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1147161006225	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1147161006226	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1147161006227	metal ion-dependent adhesion site (MIDAS); other site
1147161006228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161006229	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161006230	Walker A motif; other site
1147161006231	ATP binding site [chemical binding]; other site
1147161006232	Walker B motif; other site
1147161006233	arginine finger; other site
1147161006234	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
1147161006235	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1147161006236	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1147161006237	E-class dimer interface [polypeptide binding]; other site
1147161006238	P-class dimer interface [polypeptide binding]; other site
1147161006239	active site
1147161006240	Cu2+ binding site [ion binding]; other site
1147161006241	Zn2+ binding site [ion binding]; other site
1147161006242	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006243	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006244	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006245	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006246	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161006247	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161006248	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1147161006249	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1147161006250	active site
1147161006251	TDP-binding site; other site
1147161006252	acceptor substrate-binding pocket; other site
1147161006253	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1147161006254	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
1147161006255	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1147161006256	multidrug efflux protein; Reviewed; Region: PRK01766
1147161006257	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1147161006258	cation binding site [ion binding]; other site
1147161006259	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1147161006260	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1147161006261	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1147161006262	rarD protein; Region: rarD; TIGR00688
1147161006263	EamA-like transporter family; Region: EamA; pfam00892
1147161006264	GntP family permease; Region: GntP_permease; pfam02447
1147161006265	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1147161006266	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1147161006267	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161006268	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161006269	dimerization interface [polypeptide binding]; other site
1147161006270	putative DNA binding site [nucleotide binding]; other site
1147161006271	putative Zn2+ binding site [ion binding]; other site
1147161006272	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1147161006273	dimer interface [polypeptide binding]; other site
1147161006274	FMN binding site [chemical binding]; other site
1147161006275	Predicted esterase [General function prediction only]; Region: COG0400
1147161006276	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1147161006277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161006278	Zn binding site [ion binding]; other site
1147161006279	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1147161006280	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161006281	Zn binding site [ion binding]; other site
1147161006282	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1147161006283	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1147161006284	Na binding site [ion binding]; other site
1147161006285	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1147161006286	C-terminal peptidase (prc); Region: prc; TIGR00225
1147161006287	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1147161006288	protein binding site [polypeptide binding]; other site
1147161006289	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1147161006290	Catalytic dyad [active]
1147161006291	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161006292	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1147161006293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161006294	S-adenosylmethionine binding site [chemical binding]; other site
1147161006295	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1147161006296	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1147161006297	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1147161006298	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1147161006299	YodL-like; Region: YodL; pfam14191
1147161006300	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1147161006301	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1147161006302	active site
1147161006303	YozD-like protein; Region: YozD; pfam14162
1147161006304	hypothetical protein; Provisional; Region: PRK13672
1147161006305	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
1147161006306	toxin interface [polypeptide binding]; other site
1147161006307	Zn binding site [ion binding]; other site
1147161006308	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
1147161006309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161006310	FeS/SAM binding site; other site
1147161006311	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1147161006312	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
1147161006313	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161006314	Coenzyme A binding pocket [chemical binding]; other site
1147161006315	acetylornithine deacetylase; Validated; Region: PRK06915
1147161006316	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
1147161006317	metal binding site [ion binding]; metal-binding site
1147161006318	dimer interface [polypeptide binding]; other site
1147161006319	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1147161006320	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1147161006321	hypothetical protein; Provisional; Region: PRK06917
1147161006322	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161006323	inhibitor-cofactor binding pocket; inhibition site
1147161006324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161006325	catalytic residue [active]
1147161006326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161006327	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1147161006328	Coenzyme A binding pocket [chemical binding]; other site
1147161006329	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161006330	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161006331	active site
1147161006332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1147161006333	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1147161006334	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1147161006335	Phytase; Region: Phytase; pfam02333
1147161006336	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1147161006337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161006338	NAD(P) binding site [chemical binding]; other site
1147161006339	active site
1147161006340	Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331
1147161006341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161006342	non-specific DNA binding site [nucleotide binding]; other site
1147161006343	salt bridge; other site
1147161006344	sequence-specific DNA binding site [nucleotide binding]; other site
1147161006345	Rubrerythrin [Energy production and conversion]; Region: COG1592
1147161006346	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1147161006347	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161006348	active site
1147161006349	metal binding site [ion binding]; metal-binding site
1147161006350	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147161006351	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
1147161006352	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1147161006353	trimer interface [polypeptide binding]; other site
1147161006354	active site
1147161006355	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161006356	catalytic residues [active]
1147161006357	HNH endonuclease; Region: HNH_3; pfam13392
1147161006358	ribonucleoside-diphosphate reductase 2, operon protein nrdI; Region: nrdI; TIGR00333
1147161006359	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1147161006360	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147161006361	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
1147161006362	cofactor binding site; other site
1147161006363	DNA binding site [nucleotide binding]
1147161006364	substrate interaction site [chemical binding]; other site
1147161006365	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147161006366	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1147161006367	AAA domain; Region: AAA_33; pfam13671
1147161006368	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1147161006369	active site
1147161006370	YorP protein; Region: YorP; pfam09629
1147161006371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1147161006372	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1147161006373	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1147161006374	active site
1147161006375	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1147161006376	DHH family; Region: DHH; pfam01368
1147161006377	hypothetical protein; Provisional; Region: PRK08624
1147161006378	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
1147161006379	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1147161006380	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147161006381	ATP binding site [chemical binding]; other site
1147161006382	Walker B motif; other site
1147161006383	AAA domain; Region: AAA_24; pfam13479
1147161006384	Right handed beta helix region; Region: Beta_helix; pfam13229
1147161006385	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
1147161006386	Phage-related replication protein [General function prediction only]; Region: COG4195
1147161006387	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1147161006388	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
1147161006389	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1147161006390	active site
1147161006391	DNA binding site [nucleotide binding]
1147161006392	YoqO-like protein; Region: YoqO; pfam14037
1147161006393	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1147161006394	active site
1147161006395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4474
1147161006396	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
1147161006397	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1147161006398	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
1147161006399	YopX protein; Region: YopX; pfam09643
1147161006400	Hypothetical protein Yopt; Region: Yopt; pfam09467
1147161006401	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161006402	salt bridge; other site
1147161006403	non-specific DNA binding site [nucleotide binding]; other site
1147161006404	sequence-specific DNA binding site [nucleotide binding]; other site
1147161006405	DNA-sulfur modification-associated; Region: DndB; pfam14072
1147161006406	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1147161006407	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1147161006408	active site
1147161006409	catalytic residues [active]
1147161006410	DNA binding site [nucleotide binding]
1147161006411	Int/Topo IB signature motif; other site
1147161006412	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161006413	non-specific DNA binding site [nucleotide binding]; other site
1147161006414	salt bridge; other site
1147161006415	sequence-specific DNA binding site [nucleotide binding]; other site
1147161006416	Superinfection exclusion protein B; Region: SieB; pfam14163
1147161006417	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1147161006418	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1147161006419	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1147161006420	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161006421	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161006422	non-specific DNA binding site [nucleotide binding]; other site
1147161006423	salt bridge; other site
1147161006424	sequence-specific DNA binding site [nucleotide binding]; other site
1147161006425	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1147161006426	IHF - DNA interface [nucleotide binding]; other site
1147161006427	IHF dimer interface [polypeptide binding]; other site
1147161006428	YonK protein; Region: YonK; pfam09642
1147161006429	Terminase-like family; Region: Terminase_6; pfam03237
1147161006430	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1147161006431	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
1147161006432	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1147161006433	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1147161006434	active site
1147161006435	catalytic residues [active]
1147161006436	DNA binding site [nucleotide binding]
1147161006437	Int/Topo IB signature motif; other site
1147161006438	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1147161006439	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1147161006440	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147161006441	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147161006442	catalytic residue [active]
1147161006443	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147161006444	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147161006445	Phage-related protein [Function unknown]; Region: COG4722
1147161006446	Phage tail protein; Region: Sipho_tail; cl17486
1147161006447	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1147161006448	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
1147161006449	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1147161006450	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1147161006451	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1147161006452	amidase catalytic site [active]
1147161006453	Zn binding residues [ion binding]; other site
1147161006454	substrate binding site [chemical binding]; other site
1147161006455	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
1147161006456	holin, SPP1 family; Region: holin_SPP1; TIGR01592
1147161006457	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1147161006458	peptide S-glycosyltransferase, SunS family; Region: S_glycosyl_SunS; TIGR04195
1147161006459	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147161006460	active site
1147161006461	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161006462	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161006463	catalytic residues [active]
1147161006464	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1147161006465	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1147161006466	putative active site [active]
1147161006467	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161006468	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1147161006469	Walker A/P-loop; other site
1147161006470	ATP binding site [chemical binding]; other site
1147161006471	Q-loop/lid; other site
1147161006472	ABC transporter signature motif; other site
1147161006473	Walker B; other site
1147161006474	D-loop; other site
1147161006475	H-loop/switch region; other site
1147161006476	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1147161006477	DNA polymerase IV; Reviewed; Region: PRK03103
1147161006478	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1147161006479	active site
1147161006480	DNA binding site [nucleotide binding]
1147161006481	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1147161006482	YolD-like protein; Region: YolD; pfam08863
1147161006483	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161006484	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161006485	Coenzyme A binding pocket [chemical binding]; other site
1147161006486	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1147161006487	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
1147161006488	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1147161006489	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
1147161006490	Staphylococcal nuclease homologues; Region: SNc; smart00318
1147161006491	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1147161006492	Catalytic site; other site
1147161006493	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1147161006494	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1147161006495	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147161006496	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1147161006497	catalytic residues [active]
1147161006498	catalytic nucleophile [active]
1147161006499	Recombinase; Region: Recombinase; pfam07508
1147161006500	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1147161006501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161006502	active site
1147161006503	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1147161006504	SelR domain; Region: SelR; pfam01641
1147161006505	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1147161006506	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161006507	MarR family; Region: MarR; pfam01047
1147161006508	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1147161006509	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1147161006510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
1147161006511	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1147161006512	active site
1147161006513	catalytic triad [active]
1147161006514	oxyanion hole [active]
1147161006515	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1147161006516	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1147161006517	Cu(I) binding site [ion binding]; other site
1147161006518	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
1147161006519	threonine dehydratase; Validated; Region: PRK08639
1147161006520	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1147161006521	tetramer interface [polypeptide binding]; other site
1147161006522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161006523	catalytic residue [active]
1147161006524	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1147161006525	putative Ile/Val binding site [chemical binding]; other site
1147161006526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161006527	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161006528	Walker A motif; other site
1147161006529	ATP binding site [chemical binding]; other site
1147161006530	Walker B motif; other site
1147161006531	arginine finger; other site
1147161006532	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
1147161006533	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1147161006534	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1147161006535	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1147161006536	putative acyl-acceptor binding pocket; other site
1147161006537	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1147161006538	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1147161006539	folate binding site [chemical binding]; other site
1147161006540	NADP+ binding site [chemical binding]; other site
1147161006541	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1147161006542	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1147161006543	dimerization interface [polypeptide binding]; other site
1147161006544	active site
1147161006545	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1147161006546	tetramer interfaces [polypeptide binding]; other site
1147161006547	binuclear metal-binding site [ion binding]; other site
1147161006548	YpjP-like protein; Region: YpjP; pfam14005
1147161006549	ribosomal biogenesis protein; Validated; Region: PRK00933
1147161006550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161006551	S-adenosylmethionine binding site [chemical binding]; other site
1147161006552	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1147161006553	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1147161006554	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1147161006555	Virulence factor; Region: Virulence_fact; pfam13769
1147161006556	HEAT repeats; Region: HEAT_2; pfam13646
1147161006557	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1147161006558	HEAT repeats; Region: HEAT_2; pfam13646
1147161006559	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1147161006560	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1147161006561	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161006562	Zn2+ binding site [ion binding]; other site
1147161006563	Mg2+ binding site [ion binding]; other site
1147161006564	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1147161006565	catalytic residues [active]
1147161006566	dimer interface [polypeptide binding]; other site
1147161006567	homoserine O-succinyltransferase; Provisional; Region: PRK05368
1147161006568	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1147161006569	proposed active site lysine [active]
1147161006570	conserved cys residue [active]
1147161006571	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1147161006572	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1147161006573	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1147161006574	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1147161006575	DNA-binding site [nucleotide binding]; DNA binding site
1147161006576	RNA-binding motif; other site
1147161006577	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
1147161006578	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1147161006579	hypothetical protein; Validated; Region: PRK07708
1147161006580	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1147161006581	RNA/DNA hybrid binding site [nucleotide binding]; other site
1147161006582	active site
1147161006583	conserved hypothetical integral membrane protein; Region: TIGR00697
1147161006584	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1147161006585	RNA/DNA hybrid binding site [nucleotide binding]; other site
1147161006586	active site
1147161006587	small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093
1147161006588	5'-3' exonuclease; Region: 53EXOc; smart00475
1147161006589	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1147161006590	active site
1147161006591	metal binding site 1 [ion binding]; metal-binding site
1147161006592	putative 5' ssDNA interaction site; other site
1147161006593	metal binding site 3; metal-binding site
1147161006594	metal binding site 2 [ion binding]; metal-binding site
1147161006595	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1147161006596	putative DNA binding site [nucleotide binding]; other site
1147161006597	putative metal binding site [ion binding]; other site
1147161006598	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
1147161006599	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1147161006600	Dynamin family; Region: Dynamin_N; pfam00350
1147161006601	G1 box; other site
1147161006602	GTP/Mg2+ binding site [chemical binding]; other site
1147161006603	G2 box; other site
1147161006604	Switch I region; other site
1147161006605	G3 box; other site
1147161006606	Switch II region; other site
1147161006607	G4 box; other site
1147161006608	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1147161006609	G1 box; other site
1147161006610	GTP/Mg2+ binding site [chemical binding]; other site
1147161006611	Dynamin family; Region: Dynamin_N; pfam00350
1147161006612	G2 box; other site
1147161006613	Switch I region; other site
1147161006614	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1147161006615	G3 box; other site
1147161006616	Switch II region; other site
1147161006617	GTP/Mg2+ binding site [chemical binding]; other site
1147161006618	G4 box; other site
1147161006619	G5 box; other site
1147161006620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1147161006621	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1147161006622	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1147161006623	malonyl-CoA binding site [chemical binding]; other site
1147161006624	dimer interface [polypeptide binding]; other site
1147161006625	active site
1147161006626	product binding site; other site
1147161006627	xanthine permease; Region: pbuX; TIGR03173
1147161006628	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1147161006629	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161006630	active site
1147161006631	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1147161006632	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1147161006633	active site
1147161006634	Zn binding site [ion binding]; other site
1147161006635	2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812
1147161006636	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1147161006637	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1147161006638	active site
1147161006639	intersubunit interface [polypeptide binding]; other site
1147161006640	catalytic residue [active]
1147161006641	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1147161006642	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1147161006643	substrate binding site [chemical binding]; other site
1147161006644	ATP binding site [chemical binding]; other site
1147161006645	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161006646	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161006647	DNA binding site [nucleotide binding]
1147161006648	domain linker motif; other site
1147161006649	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1147161006650	putative dimerization interface [polypeptide binding]; other site
1147161006651	putative ligand binding site [chemical binding]; other site
1147161006652	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1147161006653	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
1147161006654	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1147161006655	NADP binding site [chemical binding]; other site
1147161006656	homodimer interface [polypeptide binding]; other site
1147161006657	active site
1147161006658	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1147161006659	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1147161006660	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1147161006661	YpzG-like protein; Region: YpzG; pfam14139
1147161006662	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1147161006663	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1147161006664	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1147161006665	cell division protein GpsB; Provisional; Region: PRK14127
1147161006666	DivIVA domain; Region: DivI1A_domain; TIGR03544
1147161006667	hypothetical protein; Provisional; Region: PRK13660
1147161006668	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
1147161006669	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
1147161006670	RNase_H superfamily; Region: RNase_H_2; pfam13482
1147161006671	active site
1147161006672	substrate binding site [chemical binding]; other site
1147161006673	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1147161006674	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1147161006675	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161006676	ATP binding site [chemical binding]; other site
1147161006677	putative Mg++ binding site [ion binding]; other site
1147161006678	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161006679	nucleotide binding region [chemical binding]; other site
1147161006680	ATP-binding site [chemical binding]; other site
1147161006681	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1147161006682	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1147161006683	HPr interaction site; other site
1147161006684	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1147161006685	active site
1147161006686	phosphorylation site [posttranslational modification]
1147161006687	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
1147161006688	YppG-like protein; Region: YppG; pfam14179
1147161006689	YppF-like protein; Region: YppF; pfam14178
1147161006690	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1147161006691	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1147161006692	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1147161006693	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1147161006694	Transglycosylase; Region: Transgly; pfam00912
1147161006695	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161006696	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147161006697	Interdomain contacts; other site
1147161006698	Cytokine receptor motif; other site
1147161006699	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1147161006700	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1147161006701	minor groove reading motif; other site
1147161006702	helix-hairpin-helix signature motif; other site
1147161006703	substrate binding pocket [chemical binding]; other site
1147161006704	active site
1147161006705	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1147161006706	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1147161006707	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1147161006708	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1147161006709	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1147161006710	putative dimer interface [polypeptide binding]; other site
1147161006711	putative anticodon binding site; other site
1147161006712	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1147161006713	homodimer interface [polypeptide binding]; other site
1147161006714	motif 1; other site
1147161006715	motif 2; other site
1147161006716	active site
1147161006717	motif 3; other site
1147161006718	aspartate aminotransferase; Provisional; Region: PRK05764
1147161006719	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161006720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161006721	homodimer interface [polypeptide binding]; other site
1147161006722	catalytic residue [active]
1147161006723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1147161006724	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147161006725	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
1147161006726	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1147161006727	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1147161006728	active site
1147161006729	catalytic site [active]
1147161006730	substrate binding site [chemical binding]; other site
1147161006731	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1147161006732	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1147161006733	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1147161006734	tetramerization interface [polypeptide binding]; other site
1147161006735	active site
1147161006736	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1147161006737	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1147161006738	active site
1147161006739	ATP-binding site [chemical binding]; other site
1147161006740	pantoate-binding site; other site
1147161006741	HXXH motif; other site
1147161006742	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1147161006743	oligomerization interface [polypeptide binding]; other site
1147161006744	active site
1147161006745	metal binding site [ion binding]; metal-binding site
1147161006746	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1147161006747	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
1147161006748	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1147161006749	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1147161006750	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1147161006751	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1147161006752	active site
1147161006753	NTP binding site [chemical binding]; other site
1147161006754	metal binding triad [ion binding]; metal-binding site
1147161006755	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1147161006756	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1147161006757	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1147161006758	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1147161006759	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1147161006760	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1147161006761	active site
1147161006762	dimer interfaces [polypeptide binding]; other site
1147161006763	catalytic residues [active]
1147161006764	dihydrodipicolinate reductase; Region: dapB; TIGR00036
1147161006765	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1147161006766	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1147161006767	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1147161006768	homodimer interface [polypeptide binding]; other site
1147161006769	metal binding site [ion binding]; metal-binding site
1147161006770	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161006771	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161006772	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161006773	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161006774	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577
1147161006775	Predicted membrane protein [Function unknown]; Region: COG4347
1147161006776	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1147161006777	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1147161006778	intrachain domain interface; other site
1147161006779	Qi binding site; other site
1147161006780	Qo binding site; other site
1147161006781	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1147161006782	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1147161006783	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1147161006784	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1147161006785	interchain domain interface [polypeptide binding]; other site
1147161006786	intrachain domain interface; other site
1147161006787	heme bH binding site [chemical binding]; other site
1147161006788	Qi binding site; other site
1147161006789	heme bL binding site [chemical binding]; other site
1147161006790	Qo binding site; other site
1147161006791	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1147161006792	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
1147161006793	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1147161006794	iron-sulfur cluster [ion binding]; other site
1147161006795	[2Fe-2S] cluster binding site [ion binding]; other site
1147161006796	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
1147161006797	hypothetical protein; Provisional; Region: PRK03636
1147161006798	UPF0302 domain; Region: UPF0302; pfam08864
1147161006799	IDEAL domain; Region: IDEAL; pfam08858
1147161006800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1147161006801	TPR motif; other site
1147161006802	binding surface
1147161006803	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1147161006804	binding surface
1147161006805	TPR motif; other site
1147161006806	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1147161006807	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161006808	TPR motif; other site
1147161006809	binding surface
1147161006810	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1147161006811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161006812	binding surface
1147161006813	TPR motif; other site
1147161006814	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1147161006815	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1147161006816	hinge; other site
1147161006817	active site
1147161006818	prephenate dehydrogenase; Validated; Region: PRK06545
1147161006819	prephenate dehydrogenase; Validated; Region: PRK08507
1147161006820	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1147161006821	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1147161006822	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161006823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161006824	homodimer interface [polypeptide binding]; other site
1147161006825	catalytic residue [active]
1147161006826	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1147161006827	substrate binding site [chemical binding]; other site
1147161006828	active site
1147161006829	catalytic residues [active]
1147161006830	heterodimer interface [polypeptide binding]; other site
1147161006831	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1147161006832	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1147161006833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161006834	catalytic residue [active]
1147161006835	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1147161006836	active site
1147161006837	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1147161006838	active site
1147161006839	ribulose/triose binding site [chemical binding]; other site
1147161006840	phosphate binding site [ion binding]; other site
1147161006841	substrate (anthranilate) binding pocket [chemical binding]; other site
1147161006842	product (indole) binding pocket [chemical binding]; other site
1147161006843	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1147161006844	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1147161006845	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1147161006846	anthranilate synthase component I; Provisional; Region: PRK13569
1147161006847	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1147161006848	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1147161006849	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1147161006850	homotrimer interaction site [polypeptide binding]; other site
1147161006851	active site
1147161006852	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1147161006853	active site
1147161006854	dimer interface [polypeptide binding]; other site
1147161006855	metal binding site [ion binding]; metal-binding site
1147161006856	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1147161006857	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1147161006858	Tetramer interface [polypeptide binding]; other site
1147161006859	active site
1147161006860	FMN-binding site [chemical binding]; other site
1147161006861	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1147161006862	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1147161006863	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1147161006864	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1147161006865	active site
1147161006866	multimer interface [polypeptide binding]; other site
1147161006867	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1147161006868	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1147161006869	substrate binding pocket [chemical binding]; other site
1147161006870	chain length determination region; other site
1147161006871	substrate-Mg2+ binding site; other site
1147161006872	catalytic residues [active]
1147161006873	aspartate-rich region 1; other site
1147161006874	active site lid residues [active]
1147161006875	aspartate-rich region 2; other site
1147161006876	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1147161006877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161006878	S-adenosylmethionine binding site [chemical binding]; other site
1147161006879	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1147161006880	Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081
1147161006881	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1147161006882	homodecamer interface [polypeptide binding]; other site
1147161006883	GTP cyclohydrolase I; Provisional; Region: PLN03044
1147161006884	active site
1147161006885	putative catalytic site residues [active]
1147161006886	zinc binding site [ion binding]; other site
1147161006887	GTP-CH-I/GFRP interaction surface; other site
1147161006888	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1147161006889	IHF dimer interface [polypeptide binding]; other site
1147161006890	IHF - DNA interface [nucleotide binding]; other site
1147161006891	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
1147161006892	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1147161006893	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
1147161006894	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1147161006895	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1147161006896	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1147161006897	GTP-binding protein Der; Reviewed; Region: PRK00093
1147161006898	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1147161006899	G1 box; other site
1147161006900	GTP/Mg2+ binding site [chemical binding]; other site
1147161006901	Switch I region; other site
1147161006902	G2 box; other site
1147161006903	Switch II region; other site
1147161006904	G3 box; other site
1147161006905	G4 box; other site
1147161006906	G5 box; other site
1147161006907	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1147161006908	G1 box; other site
1147161006909	GTP/Mg2+ binding site [chemical binding]; other site
1147161006910	Switch I region; other site
1147161006911	G2 box; other site
1147161006912	G3 box; other site
1147161006913	Switch II region; other site
1147161006914	G4 box; other site
1147161006915	G5 box; other site
1147161006916	YIEGIA protein; Region: YIEGIA; pfam14045
1147161006917	YpzI-like protein; Region: YpzI; pfam14140
1147161006918	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1147161006919	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1147161006920	homotetramer interface [polypeptide binding]; other site
1147161006921	FMN binding site [chemical binding]; other site
1147161006922	homodimer contacts [polypeptide binding]; other site
1147161006923	putative active site [active]
1147161006924	putative substrate binding site [chemical binding]; other site
1147161006925	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1147161006926	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1147161006927	RNA binding site [nucleotide binding]; other site
1147161006928	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1147161006929	RNA binding site [nucleotide binding]; other site
1147161006930	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1147161006931	RNA binding site [nucleotide binding]; other site
1147161006932	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1147161006933	RNA binding site [nucleotide binding]; other site
1147161006934	cytidylate kinase; Provisional; Region: cmk; PRK00023
1147161006935	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1147161006936	CMP-binding site; other site
1147161006937	The sites determining sugar specificity; other site
1147161006938	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1147161006939	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1147161006940	PilZ domain; Region: PilZ; pfam07238
1147161006941	germination protein YpeB; Region: spore_YpeB; TIGR02889
1147161006942	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161006943	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1147161006944	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1147161006945	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1147161006946	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1147161006947	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161006948	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1147161006949	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1147161006950	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1147161006951	NAD(P) binding site [chemical binding]; other site
1147161006952	adaptor protein; Provisional; Region: PRK02899
1147161006953	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1147161006954	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161006955	putative active site [active]
1147161006956	putative metal binding site [ion binding]; other site
1147161006957	Protein of unknown function (DUF2663); Region: DUF2663; pfam10864
1147161006958	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161006959	CAAX protease self-immunity; Region: Abi; pfam02517
1147161006960	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1147161006961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161006962	ATP binding site [chemical binding]; other site
1147161006963	putative Mg++ binding site [ion binding]; other site
1147161006964	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161006965	nucleotide binding region [chemical binding]; other site
1147161006966	ATP-binding site [chemical binding]; other site
1147161006967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1147161006968	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1147161006969	Predicted membrane protein [Function unknown]; Region: COG3601
1147161006970	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1147161006971	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1147161006972	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1147161006973	ligand binding site [chemical binding]; other site
1147161006974	NAD binding site [chemical binding]; other site
1147161006975	dimerization interface [polypeptide binding]; other site
1147161006976	catalytic site [active]
1147161006977	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1147161006978	putative L-serine binding site [chemical binding]; other site
1147161006979	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1147161006980	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1147161006981	active site
1147161006982	catalytic residue [active]
1147161006983	dimer interface [polypeptide binding]; other site
1147161006984	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
1147161006985	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161006986	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161006987	DNA binding residues [nucleotide binding]
1147161006988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1147161006989	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161006990	dimerization interface [polypeptide binding]; other site
1147161006991	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161006992	putative active site [active]
1147161006993	heme pocket [chemical binding]; other site
1147161006994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161006995	dimer interface [polypeptide binding]; other site
1147161006996	phosphorylation site [posttranslational modification]
1147161006997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161006998	ATP binding site [chemical binding]; other site
1147161006999	Mg2+ binding site [ion binding]; other site
1147161007000	G-X-G motif; other site
1147161007001	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161007002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161007003	active site
1147161007004	phosphorylation site [posttranslational modification]
1147161007005	intermolecular recognition site; other site
1147161007006	dimerization interface [polypeptide binding]; other site
1147161007007	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161007008	DNA binding site [nucleotide binding]
1147161007009	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1147161007010	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1147161007011	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1147161007012	ResB-like family; Region: ResB; pfam05140
1147161007013	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1147161007014	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161007015	catalytic residues [active]
1147161007016	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1147161007017	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161007018	RNA binding surface [nucleotide binding]; other site
1147161007019	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1147161007020	active site
1147161007021	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1147161007022	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1147161007023	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1147161007024	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1147161007025	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1147161007026	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
1147161007027	segregation and condensation protein B; Region: TIGR00281
1147161007028	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1147161007029	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1147161007030	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161007031	Coenzyme A binding pocket [chemical binding]; other site
1147161007032	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1147161007033	homopentamer interface [polypeptide binding]; other site
1147161007034	active site
1147161007035	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1147161007036	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1147161007037	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1147161007038	dimerization interface [polypeptide binding]; other site
1147161007039	active site
1147161007040	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1147161007041	Lumazine binding domain; Region: Lum_binding; pfam00677
1147161007042	Lumazine binding domain; Region: Lum_binding; pfam00677
1147161007043	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1147161007044	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1147161007045	catalytic motif [active]
1147161007046	Zn binding site [ion binding]; other site
1147161007047	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
1147161007048	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1147161007049	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147161007050	Catalytic site [active]
1147161007051	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
1147161007052	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1147161007053	active site
1147161007054	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161007055	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1147161007056	active site
1147161007057	Predicted secreted protein [Function unknown]; Region: COG4086
1147161007058	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1147161007059	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1147161007060	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1147161007061	active site
1147161007062	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147161007063	substrate binding site [chemical binding]; other site
1147161007064	catalytic residues [active]
1147161007065	dimer interface [polypeptide binding]; other site
1147161007066	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147161007067	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
1147161007068	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
1147161007069	stage V sporulation protein AD; Validated; Region: PRK08304
1147161007070	stage V sporulation protein AD; Provisional; Region: PRK12404
1147161007071	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1147161007072	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
1147161007073	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
1147161007074	sporulation sigma factor SigF; Validated; Region: PRK05572
1147161007075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161007076	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147161007077	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161007078	DNA binding residues [nucleotide binding]
1147161007079	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1147161007080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161007081	ATP binding site [chemical binding]; other site
1147161007082	Mg2+ binding site [ion binding]; other site
1147161007083	G-X-G motif; other site
1147161007084	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
1147161007085	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1147161007086	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1147161007087	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1147161007088	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1147161007089	phosphopentomutase; Provisional; Region: PRK05362
1147161007090	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1147161007091	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1147161007092	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1147161007093	active site
1147161007094	Int/Topo IB signature motif; other site
1147161007095	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
1147161007096	ferric uptake regulator; Provisional; Region: fur; PRK09462
1147161007097	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1147161007098	metal binding site 2 [ion binding]; metal-binding site
1147161007099	putative DNA binding helix; other site
1147161007100	metal binding site 1 [ion binding]; metal-binding site
1147161007101	dimer interface [polypeptide binding]; other site
1147161007102	structural Zn2+ binding site [ion binding]; other site
1147161007103	stage II sporulation protein M; Region: spo_II_M; TIGR02831
1147161007104	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1147161007105	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1147161007106	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1147161007107	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1147161007108	NAD(P) binding pocket [chemical binding]; other site
1147161007109	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1147161007110	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1147161007111	Aspartase; Region: Aspartase; cd01357
1147161007112	active sites [active]
1147161007113	tetramer interface [polypeptide binding]; other site
1147161007114	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1147161007115	active site
1147161007116	homodimer interface [polypeptide binding]; other site
1147161007117	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161007118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161007119	non-specific DNA binding site [nucleotide binding]; other site
1147161007120	salt bridge; other site
1147161007121	sequence-specific DNA binding site [nucleotide binding]; other site
1147161007122	TIGR00375 family protein; Region: TIGR00375
1147161007123	PHP-associated; Region: PHP_C; pfam13263
1147161007124	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1147161007125	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1147161007126	dimer interface [polypeptide binding]; other site
1147161007127	ADP-ribose binding site [chemical binding]; other site
1147161007128	active site
1147161007129	nudix motif; other site
1147161007130	metal binding site [ion binding]; metal-binding site
1147161007131	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161007132	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161007133	active site
1147161007134	catalytic tetrad [active]
1147161007135	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1147161007136	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147161007137	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
1147161007138	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
1147161007139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1147161007140	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1147161007141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161007142	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1147161007143	Coenzyme A binding pocket [chemical binding]; other site
1147161007144	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1147161007145	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1147161007146	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1147161007147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161007148	Coenzyme A binding pocket [chemical binding]; other site
1147161007149	YolD-like protein; Region: YolD; pfam08863
1147161007150	DNA polymerase IV; Reviewed; Region: PRK03103
1147161007151	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1147161007152	active site
1147161007153	DNA binding site [nucleotide binding]
1147161007154	YqzH-like protein; Region: YqzH; pfam14164
1147161007155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161007156	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161007157	putative substrate translocation pore; other site
1147161007158	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1147161007159	putative dimer interface [polypeptide binding]; other site
1147161007160	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161007161	ligand binding site [chemical binding]; other site
1147161007162	Zn binding site [ion binding]; other site
1147161007163	pantothenate kinase; Provisional; Region: PRK05439
1147161007164	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1147161007165	ATP-binding site [chemical binding]; other site
1147161007166	CoA-binding site [chemical binding]; other site
1147161007167	Mg2+-binding site [ion binding]; other site
1147161007168	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1147161007169	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1147161007170	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161007171	catalytic residue [active]
1147161007172	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1147161007173	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
1147161007174	NADP binding site [chemical binding]; other site
1147161007175	homodimer interface [polypeptide binding]; other site
1147161007176	substrate binding site [chemical binding]; other site
1147161007177	active site
1147161007178	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1147161007179	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1147161007180	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1147161007181	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
1147161007182	putative metal binding site [ion binding]; other site
1147161007183	putative dimer interface [polypeptide binding]; other site
1147161007184	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1147161007185	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1147161007186	active site
1147161007187	FMN binding site [chemical binding]; other site
1147161007188	substrate binding site [chemical binding]; other site
1147161007189	homotetramer interface [polypeptide binding]; other site
1147161007190	catalytic residue [active]
1147161007191	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1147161007192	putative hydrolase; Provisional; Region: PRK02113
1147161007193	ribonuclease Z; Region: RNase_Z; TIGR02651
1147161007194	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1147161007195	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1147161007196	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1147161007197	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1147161007198	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1147161007199	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1147161007200	DNA polymerase IV; Validated; Region: PRK01810
1147161007201	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1147161007202	active site
1147161007203	DNA binding site [nucleotide binding]
1147161007204	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1147161007205	OxaA-like protein precursor; Validated; Region: PRK01622
1147161007206	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1147161007207	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
1147161007208	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1147161007209	peptidase T-like protein; Region: PepT-like; TIGR01883
1147161007210	metal binding site [ion binding]; metal-binding site
1147161007211	putative dimer interface [polypeptide binding]; other site
1147161007212	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1147161007213	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1147161007214	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1147161007215	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161007216	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1147161007217	dimer interface [polypeptide binding]; other site
1147161007218	substrate binding site [chemical binding]; other site
1147161007219	metal binding site [ion binding]; metal-binding site
1147161007220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1147161007221	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1147161007222	Predicted membrane protein [Function unknown]; Region: COG4129
1147161007223	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1147161007224	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1147161007225	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1147161007226	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1147161007227	Walker A/P-loop; other site
1147161007228	ATP binding site [chemical binding]; other site
1147161007229	Q-loop/lid; other site
1147161007230	ABC transporter signature motif; other site
1147161007231	Walker B; other site
1147161007232	D-loop; other site
1147161007233	H-loop/switch region; other site
1147161007234	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1147161007235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161007236	dimer interface [polypeptide binding]; other site
1147161007237	conserved gate region; other site
1147161007238	putative PBP binding loops; other site
1147161007239	ABC-ATPase subunit interface; other site
1147161007240	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161007241	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1147161007242	substrate binding pocket [chemical binding]; other site
1147161007243	membrane-bound complex binding site; other site
1147161007244	hinge residues; other site
1147161007245	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1147161007246	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
1147161007247	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1147161007248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161007249	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161007250	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1147161007251	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1147161007252	DNA binding residues [nucleotide binding]
1147161007253	drug binding residues [chemical binding]; other site
1147161007254	dimer interface [polypeptide binding]; other site
1147161007255	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1147161007256	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1147161007257	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1147161007258	E3 interaction surface; other site
1147161007259	lipoyl attachment site [posttranslational modification]; other site
1147161007260	e3 binding domain; Region: E3_binding; pfam02817
1147161007261	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1147161007262	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1147161007263	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1147161007264	alpha subunit interface [polypeptide binding]; other site
1147161007265	TPP binding site [chemical binding]; other site
1147161007266	heterodimer interface [polypeptide binding]; other site
1147161007267	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147161007268	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1147161007269	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1147161007270	tetramer interface [polypeptide binding]; other site
1147161007271	TPP-binding site [chemical binding]; other site
1147161007272	heterodimer interface [polypeptide binding]; other site
1147161007273	phosphorylation loop region [posttranslational modification]
1147161007274	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1147161007275	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1147161007276	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161007277	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1147161007278	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161007279	nucleotide binding site [chemical binding]; other site
1147161007280	Acetokinase family; Region: Acetate_kinase; cl17229
1147161007281	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1147161007282	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1147161007283	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1147161007284	NAD binding site [chemical binding]; other site
1147161007285	Phe binding site; other site
1147161007286	phosphate butyryltransferase; Validated; Region: PRK07742
1147161007287	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1147161007288	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161007289	putative active site [active]
1147161007290	heme pocket [chemical binding]; other site
1147161007291	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161007292	putative active site [active]
1147161007293	heme pocket [chemical binding]; other site
1147161007294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161007295	Walker A motif; other site
1147161007296	ATP binding site [chemical binding]; other site
1147161007297	Walker B motif; other site
1147161007298	arginine finger; other site
1147161007299	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1147161007300	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
1147161007301	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1147161007302	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1147161007303	tetramer interface [polypeptide binding]; other site
1147161007304	active site
1147161007305	Mg2+/Mn2+ binding site [ion binding]; other site
1147161007306	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1147161007307	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1147161007308	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
1147161007309	dimer interface [polypeptide binding]; other site
1147161007310	Citrate synthase; Region: Citrate_synt; pfam00285
1147161007311	active site
1147161007312	coenzyme A binding site [chemical binding]; other site
1147161007313	citrylCoA binding site [chemical binding]; other site
1147161007314	oxalacetate/citrate binding site [chemical binding]; other site
1147161007315	catalytic triad [active]
1147161007316	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1147161007317	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1147161007318	FAD binding site [chemical binding]; other site
1147161007319	homotetramer interface [polypeptide binding]; other site
1147161007320	substrate binding pocket [chemical binding]; other site
1147161007321	catalytic base [active]
1147161007322	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1147161007323	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1147161007324	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1147161007325	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
1147161007326	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1147161007327	dimer interface [polypeptide binding]; other site
1147161007328	active site
1147161007329	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1147161007330	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1147161007331	active site
1147161007332	catalytic site [active]
1147161007333	metal binding site [ion binding]; metal-binding site
1147161007334	dimer interface [polypeptide binding]; other site
1147161007335	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
1147161007336	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1147161007337	active site
1147161007338	metal binding site [ion binding]; metal-binding site
1147161007339	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1147161007340	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1147161007341	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1147161007342	putative active site [active]
1147161007343	putative FMN binding site [chemical binding]; other site
1147161007344	putative substrate binding site [chemical binding]; other site
1147161007345	putative catalytic residue [active]
1147161007346	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1147161007347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161007348	active site
1147161007349	phosphorylation site [posttranslational modification]
1147161007350	intermolecular recognition site; other site
1147161007351	dimerization interface [polypeptide binding]; other site
1147161007352	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1147161007353	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1147161007354	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1147161007355	protein binding site [polypeptide binding]; other site
1147161007356	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1147161007357	DNA repair protein RecN; Region: recN; TIGR00634
1147161007358	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1147161007359	Walker A/P-loop; other site
1147161007360	ATP binding site [chemical binding]; other site
1147161007361	Q-loop/lid; other site
1147161007362	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1147161007363	ABC transporter signature motif; other site
1147161007364	Walker B; other site
1147161007365	D-loop; other site
1147161007366	H-loop/switch region; other site
1147161007367	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1147161007368	arginine repressor; Provisional; Region: PRK04280
1147161007369	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1147161007370	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1147161007371	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161007372	RNA binding surface [nucleotide binding]; other site
1147161007373	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1147161007374	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
1147161007375	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1147161007376	TPP-binding site; other site
1147161007377	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1147161007378	PYR/PP interface [polypeptide binding]; other site
1147161007379	dimer interface [polypeptide binding]; other site
1147161007380	TPP binding site [chemical binding]; other site
1147161007381	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147161007382	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1147161007383	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1147161007384	substrate binding pocket [chemical binding]; other site
1147161007385	chain length determination region; other site
1147161007386	substrate-Mg2+ binding site; other site
1147161007387	catalytic residues [active]
1147161007388	aspartate-rich region 1; other site
1147161007389	active site lid residues [active]
1147161007390	aspartate-rich region 2; other site
1147161007391	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
1147161007392	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
1147161007393	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1147161007394	generic binding surface II; other site
1147161007395	generic binding surface I; other site
1147161007396	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1147161007397	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1147161007398	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1147161007399	homodimer interface [polypeptide binding]; other site
1147161007400	NADP binding site [chemical binding]; other site
1147161007401	substrate binding site [chemical binding]; other site
1147161007402	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1147161007403	putative RNA binding site [nucleotide binding]; other site
1147161007404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1147161007405	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1147161007406	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147161007407	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147161007408	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1147161007409	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1147161007410	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147161007411	carboxyltransferase (CT) interaction site; other site
1147161007412	biotinylation site [posttranslational modification]; other site
1147161007413	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1147161007414	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1147161007415	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
1147161007416	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
1147161007417	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
1147161007418	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
1147161007419	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
1147161007420	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
1147161007421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161007422	Walker A motif; other site
1147161007423	ATP binding site [chemical binding]; other site
1147161007424	Walker B motif; other site
1147161007425	arginine finger; other site
1147161007426	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
1147161007427	elongation factor P; Validated; Region: PRK00529
1147161007428	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1147161007429	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1147161007430	RNA binding site [nucleotide binding]; other site
1147161007431	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1147161007432	RNA binding site [nucleotide binding]; other site
1147161007433	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1147161007434	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1147161007435	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1147161007436	active site
1147161007437	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1147161007438	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1147161007439	trimer interface [polypeptide binding]; other site
1147161007440	active site
1147161007441	dimer interface [polypeptide binding]; other site
1147161007442	Conserved membrane protein YqhR; Region: YqhR; pfam11085
1147161007443	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
1147161007444	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1147161007445	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1147161007446	active site
1147161007447	nucleophile elbow; other site
1147161007448	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1147161007449	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1147161007450	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1147161007451	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1147161007452	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1147161007453	active site residue [active]
1147161007454	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1147161007455	tetramer interface [polypeptide binding]; other site
1147161007456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161007457	catalytic residue [active]
1147161007458	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1147161007459	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1147161007460	tetramer interface [polypeptide binding]; other site
1147161007461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161007462	catalytic residue [active]
1147161007463	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1147161007464	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1147161007465	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1147161007466	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1147161007467	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161007468	ATP binding site [chemical binding]; other site
1147161007469	putative Mg++ binding site [ion binding]; other site
1147161007470	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161007471	nucleotide binding region [chemical binding]; other site
1147161007472	ATP-binding site [chemical binding]; other site
1147161007473	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
1147161007474	Anti-repressor SinI; Region: SinI; pfam08671
1147161007475	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161007476	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161007477	non-specific DNA binding site [nucleotide binding]; other site
1147161007478	salt bridge; other site
1147161007479	sequence-specific DNA binding site [nucleotide binding]; other site
1147161007480	Anti-repressor SinI; Region: SinI; pfam08671
1147161007481	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1147161007482	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
1147161007483	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147161007484	Catalytic site [active]
1147161007485	YqxM protein; Region: YqxM_for_SipW; TIGR04087
1147161007486	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1147161007487	YqzE-like protein; Region: YqzE; pfam14038
1147161007488	ComG operon protein 7; Region: ComGG; pfam14173
1147161007489	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1147161007490	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1147161007491	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1147161007492	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147161007493	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147161007494	Type II/IV secretion system protein; Region: T2SE; pfam00437
1147161007495	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1147161007496	Walker A motif; other site
1147161007497	ATP binding site [chemical binding]; other site
1147161007498	Walker B motif; other site
1147161007499	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1147161007500	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
1147161007501	Cl binding site [ion binding]; other site
1147161007502	oligomer interface [polypeptide binding]; other site
1147161007503	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1147161007504	Domain of unknown function DUF21; Region: DUF21; pfam01595
1147161007505	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1147161007506	Transporter associated domain; Region: CorC_HlyC; smart01091
1147161007507	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1147161007508	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1147161007509	ArsC family; Region: ArsC; pfam03960
1147161007510	putative catalytic residues [active]
1147161007511	thiol/disulfide switch; other site
1147161007512	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
1147161007513	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161007514	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
1147161007515	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1147161007516	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1147161007517	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
1147161007518	putative active site [active]
1147161007519	Zn binding site [ion binding]; other site
1147161007520	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1147161007521	Sulfatase; Region: Sulfatase; pfam00884
1147161007522	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1147161007523	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147161007524	nucleotide binding site [chemical binding]; other site
1147161007525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
1147161007526	Rhomboid family; Region: Rhomboid; pfam01694
1147161007527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161007528	binding surface
1147161007529	TPR motif; other site
1147161007530	TPR repeat; Region: TPR_11; pfam13414
1147161007531	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1147161007532	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1147161007533	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1147161007534	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161007535	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1147161007536	YceG-like family; Region: YceG; pfam02618
1147161007537	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274
1147161007538	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1147161007539	Walker A/P-loop; other site
1147161007540	ATP binding site [chemical binding]; other site
1147161007541	Q-loop/lid; other site
1147161007542	ABC transporter signature motif; other site
1147161007543	Walker B; other site
1147161007544	D-loop; other site
1147161007545	H-loop/switch region; other site
1147161007546	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248
1147161007547	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1147161007548	Walker A/P-loop; other site
1147161007549	ATP binding site [chemical binding]; other site
1147161007550	Q-loop/lid; other site
1147161007551	ABC transporter signature motif; other site
1147161007552	Walker B; other site
1147161007553	D-loop; other site
1147161007554	H-loop/switch region; other site
1147161007555	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1147161007556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161007557	dimer interface [polypeptide binding]; other site
1147161007558	conserved gate region; other site
1147161007559	ABC-ATPase subunit interface; other site
1147161007560	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1147161007561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161007562	dimer interface [polypeptide binding]; other site
1147161007563	conserved gate region; other site
1147161007564	putative PBP binding loops; other site
1147161007565	ABC-ATPase subunit interface; other site
1147161007566	PBP superfamily domain; Region: PBP_like_2; cl17296
1147161007567	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1147161007568	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1147161007569	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161007570	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161007571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161007572	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161007573	putative substrate translocation pore; other site
1147161007574	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1147161007575	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1147161007576	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1147161007577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1147161007578	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
1147161007579	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161007580	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1147161007581	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1147161007582	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1147161007583	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1147161007584	Uncharacterized conserved protein [Function unknown]; Region: COG5663
1147161007585	ferric uptake regulator; Provisional; Region: fur; PRK09462
1147161007586	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1147161007587	metal binding site 2 [ion binding]; metal-binding site
1147161007588	putative DNA binding helix; other site
1147161007589	metal binding site 1 [ion binding]; metal-binding site
1147161007590	dimer interface [polypeptide binding]; other site
1147161007591	structural Zn2+ binding site [ion binding]; other site
1147161007592	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161007593	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161007594	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161007595	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161007596	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
1147161007597	endonuclease IV; Provisional; Region: PRK01060
1147161007598	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1147161007599	AP (apurinic/apyrimidinic) site pocket; other site
1147161007600	DNA interaction; other site
1147161007601	Metal-binding active site; metal-binding site
1147161007602	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1147161007603	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1147161007604	ATP binding site [chemical binding]; other site
1147161007605	Mg++ binding site [ion binding]; other site
1147161007606	motif III; other site
1147161007607	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161007608	nucleotide binding region [chemical binding]; other site
1147161007609	ATP-binding site [chemical binding]; other site
1147161007610	YqfQ-like protein; Region: YqfQ; pfam14181
1147161007611	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1147161007612	LytB protein; Region: LYTB; pfam02401
1147161007613	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1147161007614	dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486
1147161007615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1147161007616	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1147161007617	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1147161007618	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1147161007619	Family of unknown function (DUF633); Region: DUF633; pfam04816
1147161007620	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1147161007621	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1147161007622	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1147161007623	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1147161007624	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1147161007625	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161007626	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147161007627	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161007628	DNA binding residues [nucleotide binding]
1147161007629	DNA primase; Validated; Region: dnaG; PRK05667
1147161007630	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1147161007631	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1147161007632	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1147161007633	active site
1147161007634	metal binding site [ion binding]; metal-binding site
1147161007635	interdomain interaction site; other site
1147161007636	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1147161007637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
1147161007638	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1147161007639	HTH domain; Region: HTH_11; pfam08279
1147161007640	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1147161007641	FOG: CBS domain [General function prediction only]; Region: COG0517
1147161007642	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
1147161007643	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1147161007644	dimer interface [polypeptide binding]; other site
1147161007645	motif 1; other site
1147161007646	active site
1147161007647	motif 2; other site
1147161007648	motif 3; other site
1147161007649	Recombination protein O N terminal; Region: RecO_N; pfam11967
1147161007650	DNA repair protein RecO; Region: reco; TIGR00613
1147161007651	Recombination protein O C terminal; Region: RecO_C; pfam02565
1147161007652	YqzL-like protein; Region: YqzL; pfam14006
1147161007653	GTPase Era; Reviewed; Region: era; PRK00089
1147161007654	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1147161007655	G1 box; other site
1147161007656	GTP/Mg2+ binding site [chemical binding]; other site
1147161007657	Switch I region; other site
1147161007658	G2 box; other site
1147161007659	Switch II region; other site
1147161007660	G3 box; other site
1147161007661	G4 box; other site
1147161007662	G5 box; other site
1147161007663	KH domain; Region: KH_2; pfam07650
1147161007664	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1147161007665	active site
1147161007666	catalytic motif [active]
1147161007667	Zn binding site [ion binding]; other site
1147161007668	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1147161007669	metal-binding heat shock protein; Provisional; Region: PRK00016
1147161007670	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1147161007671	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
1147161007672	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161007673	Zn2+ binding site [ion binding]; other site
1147161007674	Mg2+ binding site [ion binding]; other site
1147161007675	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1147161007676	PhoH-like protein; Region: PhoH; pfam02562
1147161007677	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
1147161007678	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1147161007679	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
1147161007680	hypothetical protein; Provisional; Region: PRK13665
1147161007681	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1147161007682	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
1147161007683	dimer interface [polypeptide binding]; other site
1147161007684	active site residues [active]
1147161007685	Yqey-like protein; Region: YqeY; pfam09424
1147161007686	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1147161007687	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
1147161007688	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1147161007689	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1147161007690	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1147161007691	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1147161007692	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161007693	FeS/SAM binding site; other site
1147161007694	TRAM domain; Region: TRAM; cl01282
1147161007695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1147161007696	RNA methyltransferase, RsmE family; Region: TIGR00046
1147161007697	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
1147161007698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161007699	S-adenosylmethionine binding site [chemical binding]; other site
1147161007700	chaperone protein DnaJ; Provisional; Region: PRK14280
1147161007701	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1147161007702	HSP70 interaction site [polypeptide binding]; other site
1147161007703	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1147161007704	substrate binding site [polypeptide binding]; other site
1147161007705	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1147161007706	Zn binding sites [ion binding]; other site
1147161007707	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1147161007708	dimer interface [polypeptide binding]; other site
1147161007709	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1147161007710	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1147161007711	nucleotide binding site [chemical binding]; other site
1147161007712	NEF interaction site [polypeptide binding]; other site
1147161007713	SBD interface [polypeptide binding]; other site
1147161007714	GrpE; Region: GrpE; pfam01025
1147161007715	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1147161007716	dimer interface [polypeptide binding]; other site
1147161007717	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1147161007718	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1147161007719	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1147161007720	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1147161007721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161007722	FeS/SAM binding site; other site
1147161007723	HemN C-terminal domain; Region: HemN_C; pfam06969
1147161007724	GTP-binding protein LepA; Provisional; Region: PRK05433
1147161007725	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1147161007726	G1 box; other site
1147161007727	putative GEF interaction site [polypeptide binding]; other site
1147161007728	GTP/Mg2+ binding site [chemical binding]; other site
1147161007729	Switch I region; other site
1147161007730	G2 box; other site
1147161007731	G3 box; other site
1147161007732	Switch II region; other site
1147161007733	G4 box; other site
1147161007734	G5 box; other site
1147161007735	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1147161007736	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1147161007737	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1147161007738	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
1147161007739	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1147161007740	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1147161007741	germination protease; Provisional; Region: PRK02858
1147161007742	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1147161007743	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1147161007744	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1147161007745	YqzM-like protein; Region: YqzM; pfam14141
1147161007746	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1147161007747	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1147161007748	Competence protein; Region: Competence; pfam03772
1147161007749	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161007750	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1147161007751	catalytic motif [active]
1147161007752	Zn binding site [ion binding]; other site
1147161007753	SLBB domain; Region: SLBB; pfam10531
1147161007754	comEA protein; Region: comE; TIGR01259
1147161007755	Helix-hairpin-helix motif; Region: HHH; pfam00633
1147161007756	late competence protein ComER; Validated; Region: PRK07680
1147161007757	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1147161007758	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1147161007759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161007760	S-adenosylmethionine binding site [chemical binding]; other site
1147161007761	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1147161007762	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161007763	Zn2+ binding site [ion binding]; other site
1147161007764	Mg2+ binding site [ion binding]; other site
1147161007765	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1147161007766	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1147161007767	active site
1147161007768	(T/H)XGH motif; other site
1147161007769	putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253
1147161007770	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
1147161007771	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1147161007772	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1147161007773	shikimate binding site; other site
1147161007774	NAD(P) binding site [chemical binding]; other site
1147161007775	GTPase YqeH; Provisional; Region: PRK13796
1147161007776	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1147161007777	GTP/Mg2+ binding site [chemical binding]; other site
1147161007778	G4 box; other site
1147161007779	G5 box; other site
1147161007780	G1 box; other site
1147161007781	Switch I region; other site
1147161007782	G2 box; other site
1147161007783	G3 box; other site
1147161007784	Switch II region; other site
1147161007785	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1147161007786	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161007787	active site
1147161007788	motif I; other site
1147161007789	motif II; other site
1147161007790	Sporulation inhibitor A; Region: Sda; pfam08970
1147161007791	GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657
1147161007792	active site
1147161007793	catalytic triad [active]
1147161007794	oxyanion hole [active]
1147161007795	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1147161007796	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1147161007797	amidase catalytic site [active]
1147161007798	Zn binding residues [ion binding]; other site
1147161007799	substrate binding site [chemical binding]; other site
1147161007800	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147161007801	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161007802	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1147161007803	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1147161007804	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
1147161007805	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1147161007806	arginine decarboxylase; Provisional; Region: PRK15029
1147161007807	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1147161007808	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161007809	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147161007810	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1147161007811	catalytic residues [active]
1147161007812	catalytic nucleophile [active]
1147161007813	Recombinase; Region: Recombinase; pfam07508
1147161007814	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1147161007815	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1147161007816	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1147161007817	active site
1147161007818	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1147161007819	arsenical-resistance protein; Region: acr3; TIGR00832
1147161007820	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1147161007821	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161007822	putative metal binding site [ion binding]; other site
1147161007823	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161007824	dimerization interface [polypeptide binding]; other site
1147161007825	putative DNA binding site [nucleotide binding]; other site
1147161007826	putative Zn2+ binding site [ion binding]; other site
1147161007827	Uncharacterized conserved protein [Function unknown]; Region: COG3403
1147161007828	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161007829	binding surface
1147161007830	TPR motif; other site
1147161007831	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161007832	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161007833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161007834	TPR motif; other site
1147161007835	binding surface
1147161007836	TPR repeat; Region: TPR_11; pfam13414
1147161007837	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1147161007838	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1147161007839	HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410
1147161007840	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1147161007841	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1147161007842	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1147161007843	amidase catalytic site [active]
1147161007844	Zn binding residues [ion binding]; other site
1147161007845	substrate binding site [chemical binding]; other site
1147161007846	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147161007847	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161007848	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
1147161007849	phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669
1147161007850	XkdW protein; Region: XkdW; pfam09636
1147161007851	C1q domain; Region: C1q; cl17543
1147161007852	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
1147161007853	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
1147161007854	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
1147161007855	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
1147161007856	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1147161007857	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161007858	Phage-related minor tail protein [Function unknown]; Region: COG5280
1147161007859	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147161007860	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147161007861	catalytic residue [active]
1147161007862	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
1147161007863	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
1147161007864	Domain of unknown function (DUF3599); Region: DUF3599; pfam12206
1147161007865	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
1147161007866	Phage capsid family; Region: Phage_capsid; pfam05065
1147161007867	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
1147161007868	Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518
1147161007869	Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783
1147161007870	Terminase-like family; Region: Terminase_6; pfam03237
1147161007871	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1147161007872	Helix-turn-helix domain; Region: HTH_28; pfam13518
1147161007873	Homeodomain-like domain; Region: HTH_23; cl17451
1147161007874	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
1147161007875	hypothetical protein; Provisional; Region: PRK06921
1147161007876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161007877	Walker A motif; other site
1147161007878	ATP binding site [chemical binding]; other site
1147161007879	Walker B motif; other site
1147161007880	arginine finger; other site
1147161007881	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1147161007882	Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723
1147161007883	Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377
1147161007884	Hypothetical protein Yqai; Region: Yqai; pfam09466
1147161007885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161007886	non-specific DNA binding site [nucleotide binding]; other site
1147161007887	salt bridge; other site
1147161007888	sequence-specific DNA binding site [nucleotide binding]; other site
1147161007889	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161007890	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161007891	non-specific DNA binding site [nucleotide binding]; other site
1147161007892	salt bridge; other site
1147161007893	sequence-specific DNA binding site [nucleotide binding]; other site
1147161007894	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161007895	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161007896	non-specific DNA binding site [nucleotide binding]; other site
1147161007897	salt bridge; other site
1147161007898	sequence-specific DNA binding site [nucleotide binding]; other site
1147161007899	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1147161007900	hypothetical protein; Validated; Region: PRK06217
1147161007901	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
1147161007902	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1147161007903	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161007904	DNA binding residues [nucleotide binding]
1147161007905	Predicted membrane protein [Function unknown]; Region: COG3223
1147161007906	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161007907	HAMP domain; Region: HAMP; pfam00672
1147161007908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161007909	dimer interface [polypeptide binding]; other site
1147161007910	phosphorylation site [posttranslational modification]
1147161007911	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1147161007912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161007913	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1147161007914	active site
1147161007915	phosphorylation site [posttranslational modification]
1147161007916	intermolecular recognition site; other site
1147161007917	dimerization interface [polypeptide binding]; other site
1147161007918	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161007919	DNA binding site [nucleotide binding]
1147161007920	Predicted membrane protein [Function unknown]; Region: COG2311
1147161007921	Protein of unknown function (DUF418); Region: DUF418; cl12135
1147161007922	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1147161007923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161007924	Coenzyme A binding pocket [chemical binding]; other site
1147161007925	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1147161007926	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1147161007927	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1147161007928	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1147161007929	CPxP  motif; other site
1147161007930	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1147161007931	active site residue [active]
1147161007932	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161007933	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1147161007934	CPxP  motif; other site
1147161007935	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1147161007936	active site residue [active]
1147161007937	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1147161007938	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
1147161007939	putative homodimer interface [polypeptide binding]; other site
1147161007940	putative homotetramer interface [polypeptide binding]; other site
1147161007941	putative allosteric switch controlling residues; other site
1147161007942	putative metal binding site [ion binding]; other site
1147161007943	putative homodimer-homodimer interface [polypeptide binding]; other site
1147161007944	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1147161007945	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147161007946	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
1147161007947	DNA binding residues [nucleotide binding]
1147161007948	dimer interface [polypeptide binding]; other site
1147161007949	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1147161007950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161007951	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161007952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161007953	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147161007954	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147161007955	Coenzyme A binding pocket [chemical binding]; other site
1147161007956	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1147161007957	Domain of unknown function DUF21; Region: DUF21; pfam01595
1147161007958	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1147161007959	Transporter associated domain; Region: CorC_HlyC; smart01091
1147161007960	YrzO-like protein; Region: YrzO; pfam14142
1147161007961	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161007962	EamA-like transporter family; Region: EamA; pfam00892
1147161007963	EamA-like transporter family; Region: EamA; pfam00892
1147161007964	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161007965	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161007966	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1147161007967	putative dimerization interface [polypeptide binding]; other site
1147161007968	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1147161007969	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1147161007970	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1147161007971	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1147161007972	Tautomerase enzyme; Region: Tautomerase; pfam01361
1147161007973	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161007974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161007975	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1147161007976	putative dimerization interface [polypeptide binding]; other site
1147161007977	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1147161007978	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1147161007979	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
1147161007980	4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346
1147161007981	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1147161007982	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161007983	putative DNA binding site [nucleotide binding]; other site
1147161007984	putative Zn2+ binding site [ion binding]; other site
1147161007985	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161007986	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1147161007987	RNAase interaction site [polypeptide binding]; other site
1147161007988	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161007989	Cytochrome P450; Region: p450; cl12078
1147161007990	Isochorismatase family; Region: Isochorismatase; pfam00857
1147161007991	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1147161007992	catalytic triad [active]
1147161007993	conserved cis-peptide bond; other site
1147161007994	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
1147161007995	DinB family; Region: DinB; pfam05163
1147161007996	DinB superfamily; Region: DinB_2; pfam12867
1147161007997	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1147161007998	Nitronate monooxygenase; Region: NMO; pfam03060
1147161007999	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1147161008000	FMN binding site [chemical binding]; other site
1147161008001	substrate binding site [chemical binding]; other site
1147161008002	putative catalytic residue [active]
1147161008003	glutamate racemase; Region: glut_race; TIGR00067
1147161008004	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
1147161008005	putative binding site; other site
1147161008006	putative dimer interface [polypeptide binding]; other site
1147161008007	YodA lipocalin-like domain; Region: YodA; pfam09223
1147161008008	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
1147161008009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161008010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161008011	DNA binding residues [nucleotide binding]
1147161008012	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161008013	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161008014	active site
1147161008015	catalytic tetrad [active]
1147161008016	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
1147161008017	Citrate transporter; Region: CitMHS; pfam03600
1147161008018	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161008019	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161008020	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161008021	dimerization interface [polypeptide binding]; other site
1147161008022	PrpF protein; Region: PrpF; pfam04303
1147161008023	Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978
1147161008024	chitosan binding site [chemical binding]; other site
1147161008025	catalytic residues [active]
1147161008026	Mor transcription activator family; Region: Mor; cl02360
1147161008027	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161008028	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147161008029	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1147161008030	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1147161008031	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1147161008032	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1147161008033	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161008034	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1147161008035	active site
1147161008036	metal binding site [ion binding]; metal-binding site
1147161008037	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1147161008038	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1147161008039	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1147161008040	NAD binding site [chemical binding]; other site
1147161008041	catalytic Zn binding site [ion binding]; other site
1147161008042	structural Zn binding site [ion binding]; other site
1147161008043	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1147161008044	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147161008045	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1147161008046	DNA binding residues [nucleotide binding]
1147161008047	putative dimer interface [polypeptide binding]; other site
1147161008048	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1147161008049	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1147161008050	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1147161008051	putative NAD(P) binding site [chemical binding]; other site
1147161008052	putative substrate binding site [chemical binding]; other site
1147161008053	catalytic Zn binding site [ion binding]; other site
1147161008054	structural Zn binding site [ion binding]; other site
1147161008055	dimer interface [polypeptide binding]; other site
1147161008056	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1147161008057	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1147161008058	proposed catalytic triad [active]
1147161008059	conserved cys residue [active]
1147161008060	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1147161008061	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1147161008062	substrate binding [chemical binding]; other site
1147161008063	active site
1147161008064	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1147161008065	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
1147161008066	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
1147161008067	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1147161008068	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1147161008069	active site
1147161008070	phosphorylation site [posttranslational modification]
1147161008071	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1147161008072	active pocket/dimerization site; other site
1147161008073	active site
1147161008074	phosphorylation site [posttranslational modification]
1147161008075	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1147161008076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008077	Walker A motif; other site
1147161008078	ATP binding site [chemical binding]; other site
1147161008079	Walker B motif; other site
1147161008080	arginine finger; other site
1147161008081	Transcriptional antiterminator [Transcription]; Region: COG3933
1147161008082	PRD domain; Region: PRD; pfam00874
1147161008083	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1147161008084	active pocket/dimerization site; other site
1147161008085	active site
1147161008086	phosphorylation site [posttranslational modification]
1147161008087	PRD domain; Region: PRD; pfam00874
1147161008088	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1147161008089	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
1147161008090	Predicted transcriptional regulators [Transcription]; Region: COG1378
1147161008091	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1147161008092	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1147161008093	C-terminal domain interface [polypeptide binding]; other site
1147161008094	sugar binding site [chemical binding]; other site
1147161008095	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147161008096	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161008097	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161008098	DNA binding residues [nucleotide binding]
1147161008099	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1147161008100	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1147161008101	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1147161008102	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1147161008103	catalytic triad [active]
1147161008104	catalytic triad [active]
1147161008105	oxyanion hole [active]
1147161008106	YrhK-like protein; Region: YrhK; pfam14145
1147161008107	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161008108	Cytochrome P450; Region: p450; pfam00067
1147161008109	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1147161008110	Flavodoxin; Region: Flavodoxin_1; pfam00258
1147161008111	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1147161008112	FAD binding pocket [chemical binding]; other site
1147161008113	FAD binding motif [chemical binding]; other site
1147161008114	catalytic residues [active]
1147161008115	NAD binding pocket [chemical binding]; other site
1147161008116	phosphate binding motif [ion binding]; other site
1147161008117	beta-alpha-beta structure motif; other site
1147161008118	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161008119	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161008120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161008121	S-adenosylmethionine binding site [chemical binding]; other site
1147161008122	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
1147161008123	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1147161008124	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1147161008125	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1147161008126	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147161008127	catalytic loop [active]
1147161008128	iron binding site [ion binding]; other site
1147161008129	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1147161008130	4Fe-4S binding domain; Region: Fer4; pfam00037
1147161008131	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1147161008132	[4Fe-4S] binding site [ion binding]; other site
1147161008133	molybdopterin cofactor binding site; other site
1147161008134	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1147161008135	molybdopterin cofactor binding site; other site
1147161008136	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1147161008137	YrhC-like protein; Region: YrhC; pfam14143
1147161008138	cystathionine beta-lyase; Provisional; Region: PRK07671
1147161008139	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1147161008140	homodimer interface [polypeptide binding]; other site
1147161008141	substrate-cofactor binding pocket; other site
1147161008142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161008143	catalytic residue [active]
1147161008144	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1147161008145	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1147161008146	dimer interface [polypeptide binding]; other site
1147161008147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161008148	catalytic residue [active]
1147161008149	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1147161008150	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1147161008151	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1147161008152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161008153	S-adenosylmethionine binding site [chemical binding]; other site
1147161008154	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
1147161008155	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1147161008156	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1147161008157	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147161008158	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147161008159	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1147161008160	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1147161008161	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1147161008162	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1147161008163	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1147161008164	ATP-binding site [chemical binding]; other site
1147161008165	Sugar specificity; other site
1147161008166	Pyrimidine base specificity; other site
1147161008167	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1147161008168	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1147161008169	Peptidase family U32; Region: Peptidase_U32; pfam01136
1147161008170	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1147161008171	Peptidase family U32; Region: Peptidase_U32; pfam01136
1147161008172	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1147161008173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161008174	S-adenosylmethionine binding site [chemical binding]; other site
1147161008175	conserved hypothetical protein, YceG family; Region: TIGR00247
1147161008176	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1147161008177	dimerization interface [polypeptide binding]; other site
1147161008178	hypothetical protein; Provisional; Region: PRK13678
1147161008179	RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250
1147161008180	hypothetical protein; Provisional; Region: PRK05473
1147161008181	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1147161008182	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1147161008183	motif 1; other site
1147161008184	active site
1147161008185	motif 2; other site
1147161008186	motif 3; other site
1147161008187	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1147161008188	DHHA1 domain; Region: DHHA1; pfam02272
1147161008189	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1147161008190	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147161008191	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1147161008192	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1147161008193	Walker A/P-loop; other site
1147161008194	ATP binding site [chemical binding]; other site
1147161008195	Q-loop/lid; other site
1147161008196	ABC transporter signature motif; other site
1147161008197	Walker B; other site
1147161008198	D-loop; other site
1147161008199	H-loop/switch region; other site
1147161008200	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1147161008201	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161008202	substrate binding pocket [chemical binding]; other site
1147161008203	membrane-bound complex binding site; other site
1147161008204	hinge residues; other site
1147161008205	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1147161008206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161008207	dimer interface [polypeptide binding]; other site
1147161008208	conserved gate region; other site
1147161008209	putative PBP binding loops; other site
1147161008210	ABC-ATPase subunit interface; other site
1147161008211	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
1147161008212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161008213	dimer interface [polypeptide binding]; other site
1147161008214	ABC-ATPase subunit interface; other site
1147161008215	putative PBP binding loops; other site
1147161008216	Protein of unknown function (DUF3918); Region: DUF3918; pfam13056
1147161008217	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
1147161008218	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1147161008219	AAA domain; Region: AAA_30; pfam13604
1147161008220	Family description; Region: UvrD_C_2; pfam13538
1147161008221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161008222	TPR motif; other site
1147161008223	TPR repeat; Region: TPR_11; pfam13414
1147161008224	binding surface
1147161008225	TPR repeat; Region: TPR_11; pfam13414
1147161008226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161008227	binding surface
1147161008228	TPR motif; other site
1147161008229	TPR repeat; Region: TPR_11; pfam13414
1147161008230	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161008231	binding surface
1147161008232	TPR motif; other site
1147161008233	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1147161008234	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1147161008235	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1147161008236	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1147161008237	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161008238	catalytic residue [active]
1147161008239	Predicted transcriptional regulator [Transcription]; Region: COG1959
1147161008240	Transcriptional regulator; Region: Rrf2; pfam02082
1147161008241	recombination factor protein RarA; Reviewed; Region: PRK13342
1147161008242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008243	Walker A motif; other site
1147161008244	ATP binding site [chemical binding]; other site
1147161008245	Walker B motif; other site
1147161008246	arginine finger; other site
1147161008247	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1147161008248	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1147161008249	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1147161008250	putative ATP binding site [chemical binding]; other site
1147161008251	putative substrate interface [chemical binding]; other site
1147161008252	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1147161008253	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1147161008254	dimer interface [polypeptide binding]; other site
1147161008255	anticodon binding site; other site
1147161008256	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1147161008257	homodimer interface [polypeptide binding]; other site
1147161008258	motif 1; other site
1147161008259	active site
1147161008260	motif 2; other site
1147161008261	GAD domain; Region: GAD; pfam02938
1147161008262	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1147161008263	motif 3; other site
1147161008264	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1147161008265	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1147161008266	dimer interface [polypeptide binding]; other site
1147161008267	motif 1; other site
1147161008268	active site
1147161008269	motif 2; other site
1147161008270	motif 3; other site
1147161008271	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1147161008272	anticodon binding site; other site
1147161008273	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
1147161008274	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1147161008275	Bacterial SH3 domain; Region: SH3_3; pfam08239
1147161008276	Bacterial SH3 domain; Region: SH3_3; pfam08239
1147161008277	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1147161008278	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1147161008279	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1147161008280	active site
1147161008281	metal binding site [ion binding]; metal-binding site
1147161008282	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1147161008283	dimerization interface [polypeptide binding]; other site
1147161008284	putative tRNAtyr binding site [nucleotide binding]; other site
1147161008285	putative active site [active]
1147161008286	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1147161008287	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161008288	Zn2+ binding site [ion binding]; other site
1147161008289	Mg2+ binding site [ion binding]; other site
1147161008290	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1147161008291	synthetase active site [active]
1147161008292	NTP binding site [chemical binding]; other site
1147161008293	metal binding site [ion binding]; metal-binding site
1147161008294	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1147161008295	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1147161008296	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161008297	active site
1147161008298	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1147161008299	DHH family; Region: DHH; pfam01368
1147161008300	DHHA1 domain; Region: DHHA1; pfam02272
1147161008301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1147161008302	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1147161008303	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1147161008304	TrkA-C domain; Region: TrkA_C; pfam02080
1147161008305	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1147161008306	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1147161008307	Protein export membrane protein; Region: SecD_SecF; pfam02355
1147161008308	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1147161008309	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1147161008310	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1147161008311	Predicted membrane protein [Function unknown]; Region: COG2323
1147161008312	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
1147161008313	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1147161008314	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1147161008315	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1147161008316	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1147161008317	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1147161008318	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1147161008319	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1147161008320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008321	Walker A motif; other site
1147161008322	ATP binding site [chemical binding]; other site
1147161008323	Walker B motif; other site
1147161008324	arginine finger; other site
1147161008325	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1147161008326	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1147161008327	RuvA N terminal domain; Region: RuvA_N; pfam01330
1147161008328	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1147161008329	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
1147161008330	BofC C-terminal domain; Region: BofC_C; pfam08955
1147161008331	polyol permease family; Region: 2A0118; TIGR00897
1147161008332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161008333	putative substrate translocation pore; other site
1147161008334	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161008335	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161008336	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161008337	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1147161008338	active site
1147161008339	substrate binding site [chemical binding]; other site
1147161008340	ATP binding site [chemical binding]; other site
1147161008341	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1147161008342	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1147161008343	hypothetical protein; Validated; Region: PRK00110
1147161008344	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1147161008345	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161008346	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147161008347	quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550
1147161008348	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
1147161008349	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1147161008350	dimerization interface [polypeptide binding]; other site
1147161008351	active site
1147161008352	L-aspartate oxidase; Provisional; Region: PRK08071
1147161008353	L-aspartate oxidase; Provisional; Region: PRK06175
1147161008354	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1147161008355	cysteine desulfurase; Provisional; Region: PRK02948
1147161008356	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1147161008357	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161008358	catalytic residue [active]
1147161008359	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1147161008360	HTH domain; Region: HTH_11; pfam08279
1147161008361	3H domain; Region: 3H; pfam02829
1147161008362	prephenate dehydratase; Provisional; Region: PRK11898
1147161008363	Prephenate dehydratase; Region: PDT; pfam00800
1147161008364	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1147161008365	putative L-Phe binding site [chemical binding]; other site
1147161008366	hypothetical protein; Provisional; Region: PRK04435
1147161008367	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
1147161008368	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1147161008369	GTP1/OBG; Region: GTP1_OBG; pfam01018
1147161008370	Obg GTPase; Region: Obg; cd01898
1147161008371	G1 box; other site
1147161008372	GTP/Mg2+ binding site [chemical binding]; other site
1147161008373	Switch I region; other site
1147161008374	G2 box; other site
1147161008375	G3 box; other site
1147161008376	Switch II region; other site
1147161008377	G4 box; other site
1147161008378	G5 box; other site
1147161008379	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1147161008380	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1147161008381	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1147161008382	hypothetical protein; Provisional; Region: PRK14553
1147161008383	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1147161008384	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1147161008385	L21 leader
1147161008386	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1147161008387	active site
1147161008388	Peptidase family M50; Region: Peptidase_M50; pfam02163
1147161008389	putative substrate binding region [chemical binding]; other site
1147161008390	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147161008391	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147161008392	septum site-determining protein MinD; Region: minD_bact; TIGR01968
1147161008393	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1147161008394	Switch I; other site
1147161008395	Switch II; other site
1147161008396	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1147161008397	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1147161008398	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1147161008399	rod shape-determining protein MreC; Region: mreC; TIGR00219
1147161008400	rod shape-determining protein MreC; Region: MreC; pfam04085
1147161008401	rod shape-determining protein MreB; Provisional; Region: PRK13927
1147161008402	MreB and similar proteins; Region: MreB_like; cd10225
1147161008403	nucleotide binding site [chemical binding]; other site
1147161008404	Mg binding site [ion binding]; other site
1147161008405	putative protofilament interaction site [polypeptide binding]; other site
1147161008406	RodZ interaction site [polypeptide binding]; other site
1147161008407	hypothetical protein; Reviewed; Region: PRK00024
1147161008408	Helix-hairpin-helix motif; Region: HHH; pfam00633
1147161008409	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1147161008410	MPN+ (JAMM) motif; other site
1147161008411	Zinc-binding site [ion binding]; other site
1147161008412	Maf-like protein; Region: Maf; pfam02545
1147161008413	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1147161008414	active site
1147161008415	dimer interface [polypeptide binding]; other site
1147161008416	Sporulation related domain; Region: SPOR; pfam05036
1147161008417	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1147161008418	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1147161008419	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1147161008420	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1147161008421	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147161008422	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147161008423	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1147161008424	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1147161008425	active site
1147161008426	HIGH motif; other site
1147161008427	nucleotide binding site [chemical binding]; other site
1147161008428	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1147161008429	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1147161008430	active site
1147161008431	KMSKS motif; other site
1147161008432	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1147161008433	tRNA binding surface [nucleotide binding]; other site
1147161008434	anticodon binding site; other site
1147161008435	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1147161008436	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
1147161008437	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
1147161008438	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147161008439	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1147161008440	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161008441	inhibitor-cofactor binding pocket; inhibition site
1147161008442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161008443	catalytic residue [active]
1147161008444	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1147161008445	dimer interface [polypeptide binding]; other site
1147161008446	active site
1147161008447	Schiff base residues; other site
1147161008448	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1147161008449	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1147161008450	active site
1147161008451	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1147161008452	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1147161008453	domain interfaces; other site
1147161008454	active site
1147161008455	Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578
1147161008456	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1147161008457	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1147161008458	tRNA; other site
1147161008459	putative tRNA binding site [nucleotide binding]; other site
1147161008460	putative NADP binding site [chemical binding]; other site
1147161008461	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1147161008462	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1147161008463	G1 box; other site
1147161008464	GTP/Mg2+ binding site [chemical binding]; other site
1147161008465	Switch I region; other site
1147161008466	G2 box; other site
1147161008467	G3 box; other site
1147161008468	Switch II region; other site
1147161008469	G4 box; other site
1147161008470	G5 box; other site
1147161008471	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1147161008472	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1147161008473	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1147161008474	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008475	Walker A motif; other site
1147161008476	ATP binding site [chemical binding]; other site
1147161008477	Walker B motif; other site
1147161008478	arginine finger; other site
1147161008479	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1147161008480	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1147161008481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008482	Walker A motif; other site
1147161008483	ATP binding site [chemical binding]; other site
1147161008484	Walker B motif; other site
1147161008485	arginine finger; other site
1147161008486	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1147161008487	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1147161008488	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1147161008489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008490	Walker A motif; other site
1147161008491	ATP binding site [chemical binding]; other site
1147161008492	Walker B motif; other site
1147161008493	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1147161008494	trigger factor; Provisional; Region: tig; PRK01490
1147161008495	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1147161008496	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1147161008497	TPR repeat; Region: TPR_11; pfam13414
1147161008498	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161008499	binding surface
1147161008500	TPR motif; other site
1147161008501	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1147161008502	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1147161008503	substrate binding site [chemical binding]; other site
1147161008504	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1147161008505	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1147161008506	substrate binding site [chemical binding]; other site
1147161008507	ligand binding site [chemical binding]; other site
1147161008508	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1147161008509	tartrate dehydrogenase; Region: TTC; TIGR02089
1147161008510	2-isopropylmalate synthase; Validated; Region: PRK00915
1147161008511	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1147161008512	active site
1147161008513	catalytic residues [active]
1147161008514	metal binding site [ion binding]; metal-binding site
1147161008515	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1147161008516	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1147161008517	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1147161008518	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1147161008519	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1147161008520	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1147161008521	putative valine binding site [chemical binding]; other site
1147161008522	dimer interface [polypeptide binding]; other site
1147161008523	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1147161008524	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1147161008525	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1147161008526	PYR/PP interface [polypeptide binding]; other site
1147161008527	dimer interface [polypeptide binding]; other site
1147161008528	TPP binding site [chemical binding]; other site
1147161008529	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147161008530	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1147161008531	TPP-binding site [chemical binding]; other site
1147161008532	dimer interface [polypeptide binding]; other site
1147161008533	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1147161008534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161008535	Coenzyme A binding pocket [chemical binding]; other site
1147161008536	Heat induced stress protein YflT; Region: YflT; pfam11181
1147161008537	conserved domain; Region: TIGR02271
1147161008538	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1147161008539	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161008540	active site
1147161008541	metal binding site [ion binding]; metal-binding site
1147161008542	homotetramer interface [polypeptide binding]; other site
1147161008543	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1147161008544	active site
1147161008545	dimerization interface [polypeptide binding]; other site
1147161008546	ribonuclease PH; Reviewed; Region: rph; PRK00173
1147161008547	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1147161008548	hexamer interface [polypeptide binding]; other site
1147161008549	active site
1147161008550	Spore germination protein [General function prediction only]; Region: COG5401
1147161008551	Sporulation and spore germination; Region: Germane; pfam10646
1147161008552	Sporulation and spore germination; Region: Germane; pfam10646
1147161008553	glutamate racemase; Region: glut_race; TIGR00067
1147161008554	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161008555	MarR family; Region: MarR; pfam01047
1147161008556	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161008557	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161008558	DNA binding residues [nucleotide binding]
1147161008559	dimerization interface [polypeptide binding]; other site
1147161008560	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1147161008561	active site
1147161008562	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1147161008563	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1147161008564	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147161008565	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1147161008566	L-aspartate oxidase; Provisional; Region: PRK06175
1147161008567	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1147161008568	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1147161008569	putative Iron-sulfur protein interface [polypeptide binding]; other site
1147161008570	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1147161008571	proximal heme binding site [chemical binding]; other site
1147161008572	distal heme binding site [chemical binding]; other site
1147161008573	putative dimer interface [polypeptide binding]; other site
1147161008574	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1147161008575	aspartate kinase; Reviewed; Region: PRK06635
1147161008576	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1147161008577	putative nucleotide binding site [chemical binding]; other site
1147161008578	putative catalytic residues [active]
1147161008579	putative Mg ion binding site [ion binding]; other site
1147161008580	putative aspartate binding site [chemical binding]; other site
1147161008581	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1147161008582	putative allosteric regulatory site; other site
1147161008583	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1147161008584	putative allosteric regulatory residue; other site
1147161008585	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1147161008586	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1147161008587	GIY-YIG motif/motif A; other site
1147161008588	active site
1147161008589	catalytic site [active]
1147161008590	putative DNA binding site [nucleotide binding]; other site
1147161008591	metal binding site [ion binding]; metal-binding site
1147161008592	UvrB/uvrC motif; Region: UVR; pfam02151
1147161008593	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1147161008594	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161008595	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147161008596	catalytic residues [active]
1147161008597	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1147161008598	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1147161008599	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1147161008600	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1147161008601	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1147161008602	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1147161008603	Ligand binding site [chemical binding]; other site
1147161008604	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1147161008605	enoyl-CoA hydratase; Provisional; Region: PRK07658
1147161008606	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161008607	substrate binding site [chemical binding]; other site
1147161008608	oxyanion hole (OAH) forming residues; other site
1147161008609	trimer interface [polypeptide binding]; other site
1147161008610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161008611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161008612	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1147161008613	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1147161008614	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1147161008615	acyl-activating enzyme (AAE) consensus motif; other site
1147161008616	putative AMP binding site [chemical binding]; other site
1147161008617	putative active site [active]
1147161008618	putative CoA binding site [chemical binding]; other site
1147161008619	Predicted membrane protein [Function unknown]; Region: COG3766
1147161008620	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1147161008621	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1147161008622	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1147161008623	MutS domain III; Region: MutS_III; pfam05192
1147161008624	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1147161008625	Walker A/P-loop; other site
1147161008626	ATP binding site [chemical binding]; other site
1147161008627	Q-loop/lid; other site
1147161008628	ABC transporter signature motif; other site
1147161008629	Walker B; other site
1147161008630	D-loop; other site
1147161008631	H-loop/switch region; other site
1147161008632	Smr domain; Region: Smr; pfam01713
1147161008633	hypothetical protein; Provisional; Region: PRK08609
1147161008634	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1147161008635	active site
1147161008636	primer binding site [nucleotide binding]; other site
1147161008637	NTP  binding site [chemical binding]; other site
1147161008638	metal binding triad [ion binding]; metal-binding site
1147161008639	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1147161008640	active site
1147161008641	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1147161008642	Colicin V production protein; Region: Colicin_V; pfam02674
1147161008643	cell division protein ZapA; Provisional; Region: PRK14126
1147161008644	ribonuclease HIII; Provisional; Region: PRK00996
1147161008645	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1147161008646	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1147161008647	RNA/DNA hybrid binding site [nucleotide binding]; other site
1147161008648	active site
1147161008649	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1147161008650	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1147161008651	putative tRNA-binding site [nucleotide binding]; other site
1147161008652	B3/4 domain; Region: B3_4; pfam03483
1147161008653	tRNA synthetase B5 domain; Region: B5; smart00874
1147161008654	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1147161008655	dimer interface [polypeptide binding]; other site
1147161008656	motif 1; other site
1147161008657	motif 3; other site
1147161008658	motif 2; other site
1147161008659	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1147161008660	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1147161008661	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1147161008662	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1147161008663	dimer interface [polypeptide binding]; other site
1147161008664	motif 1; other site
1147161008665	active site
1147161008666	motif 2; other site
1147161008667	motif 3; other site
1147161008668	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1147161008669	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1147161008670	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1147161008671	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
1147161008672	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1147161008673	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1147161008674	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147161008675	FAD binding domain; Region: FAD_binding_4; pfam01565
1147161008676	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1147161008677	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147161008678	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1147161008679	Cysteine-rich domain; Region: CCG; pfam02754
1147161008680	Cysteine-rich domain; Region: CCG; pfam02754
1147161008681	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1147161008682	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161008683	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1147161008684	Carbon starvation protein CstA; Region: CstA; pfam02554
1147161008685	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1147161008686	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1147161008687	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1147161008688	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161008689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161008690	putative PBP binding loops; other site
1147161008691	dimer interface [polypeptide binding]; other site
1147161008692	ABC-ATPase subunit interface; other site
1147161008693	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1147161008694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161008695	dimer interface [polypeptide binding]; other site
1147161008696	conserved gate region; other site
1147161008697	putative PBP binding loops; other site
1147161008698	ABC-ATPase subunit interface; other site
1147161008699	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147161008700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161008701	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1147161008702	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
1147161008703	active site
1147161008704	metal binding site [ion binding]; metal-binding site
1147161008705	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1147161008706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161008707	active site
1147161008708	motif I; other site
1147161008709	motif II; other site
1147161008710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161008711	motif II; other site
1147161008712	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1147161008713	L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760
1147161008714	intersubunit interface [polypeptide binding]; other site
1147161008715	active site
1147161008716	Zn2+ binding site [ion binding]; other site
1147161008717	L-ribulokinase; Region: L-ribulokinase; TIGR01234
1147161008718	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1147161008719	N- and C-terminal domain interface [polypeptide binding]; other site
1147161008720	active site
1147161008721	MgATP binding site [chemical binding]; other site
1147161008722	catalytic site [active]
1147161008723	metal binding site [ion binding]; metal-binding site
1147161008724	carbohydrate binding site [chemical binding]; other site
1147161008725	homodimer interface [polypeptide binding]; other site
1147161008726	L-arabinose isomerase; Provisional; Region: PRK02929
1147161008727	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1147161008728	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1147161008729	trimer interface [polypeptide binding]; other site
1147161008730	putative substrate binding site [chemical binding]; other site
1147161008731	putative metal binding site [ion binding]; other site
1147161008732	Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988
1147161008733	substrate binding site [chemical binding]; other site
1147161008734	active site
1147161008735	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1147161008736	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1147161008737	oligomer interface [polypeptide binding]; other site
1147161008738	active site
1147161008739	metal binding site [ion binding]; metal-binding site
1147161008740	Predicted membrane protein [Function unknown]; Region: COG3326
1147161008741	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1147161008742	23S rRNA binding site [nucleotide binding]; other site
1147161008743	L21 binding site [polypeptide binding]; other site
1147161008744	L13 binding site [polypeptide binding]; other site
1147161008745	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1147161008746	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1147161008747	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1147161008748	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1147161008749	L20_leader; BSU6051_2887010
1147161008750	antiholin-like protein LrgB; Provisional; Region: PRK04288
1147161008751	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1147161008752	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1147161008753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161008754	active site
1147161008755	phosphorylation site [posttranslational modification]
1147161008756	intermolecular recognition site; other site
1147161008757	dimerization interface [polypeptide binding]; other site
1147161008758	LytTr DNA-binding domain; Region: LytTR; pfam04397
1147161008759	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1147161008760	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1147161008761	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1147161008762	Histidine kinase; Region: His_kinase; pfam06580
1147161008763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161008764	ATP binding site [chemical binding]; other site
1147161008765	Mg2+ binding site [ion binding]; other site
1147161008766	G-X-G motif; other site
1147161008767	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1147161008768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161008769	motif II; other site
1147161008770	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1147161008771	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1147161008772	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1147161008773	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1147161008774	active site
1147161008775	dimer interface [polypeptide binding]; other site
1147161008776	motif 1; other site
1147161008777	motif 2; other site
1147161008778	motif 3; other site
1147161008779	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1147161008780	anticodon binding site; other site
1147161008781	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
1147161008782	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1147161008783	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1147161008784	primosomal protein DnaI; Reviewed; Region: PRK08939
1147161008785	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1147161008786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161008787	Walker A motif; other site
1147161008788	ATP binding site [chemical binding]; other site
1147161008789	Walker B motif; other site
1147161008790	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1147161008791	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1147161008792	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1147161008793	ATP cone domain; Region: ATP-cone; pfam03477
1147161008794	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
1147161008795	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1147161008796	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1147161008797	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1147161008798	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161008799	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161008800	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161008801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161008802	putative substrate translocation pore; other site
1147161008803	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161008804	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161008805	active site
1147161008806	catalytic tetrad [active]
1147161008807	dephospho-CoA kinase; Region: TIGR00152
1147161008808	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1147161008809	CoA-binding site [chemical binding]; other site
1147161008810	ATP-binding [chemical binding]; other site
1147161008811	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1147161008812	Domain of unknown function DUF; Region: DUF204; pfam02659
1147161008813	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1147161008814	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1147161008815	DNA binding site [nucleotide binding]
1147161008816	catalytic residue [active]
1147161008817	H2TH interface [polypeptide binding]; other site
1147161008818	putative catalytic residues [active]
1147161008819	turnover-facilitating residue; other site
1147161008820	intercalation triad [nucleotide binding]; other site
1147161008821	8OG recognition residue [nucleotide binding]; other site
1147161008822	putative reading head residues; other site
1147161008823	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1147161008824	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1147161008825	DNA polymerase I; Provisional; Region: PRK05755
1147161008826	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1147161008827	active site
1147161008828	metal binding site 1 [ion binding]; metal-binding site
1147161008829	putative 5' ssDNA interaction site; other site
1147161008830	metal binding site 3; metal-binding site
1147161008831	metal binding site 2 [ion binding]; metal-binding site
1147161008832	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1147161008833	putative DNA binding site [nucleotide binding]; other site
1147161008834	putative metal binding site [ion binding]; other site
1147161008835	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1147161008836	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1147161008837	active site
1147161008838	DNA binding site [nucleotide binding]
1147161008839	catalytic site [active]
1147161008840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1147161008841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161008842	putative active site [active]
1147161008843	heme pocket [chemical binding]; other site
1147161008844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161008845	dimer interface [polypeptide binding]; other site
1147161008846	phosphorylation site [posttranslational modification]
1147161008847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161008848	ATP binding site [chemical binding]; other site
1147161008849	Mg2+ binding site [ion binding]; other site
1147161008850	G-X-G motif; other site
1147161008851	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161008852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161008853	active site
1147161008854	phosphorylation site [posttranslational modification]
1147161008855	intermolecular recognition site; other site
1147161008856	dimerization interface [polypeptide binding]; other site
1147161008857	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161008858	DNA binding site [nucleotide binding]
1147161008859	malate dehydrogenase; Reviewed; Region: PRK06223
1147161008860	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1147161008861	NAD(P) binding site [chemical binding]; other site
1147161008862	dimer interface [polypeptide binding]; other site
1147161008863	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161008864	substrate binding site [chemical binding]; other site
1147161008865	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1147161008866	isocitrate dehydrogenase; Validated; Region: PRK07362
1147161008867	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1147161008868	dimer interface [polypeptide binding]; other site
1147161008869	Citrate synthase; Region: Citrate_synt; pfam00285
1147161008870	active site
1147161008871	citrylCoA binding site [chemical binding]; other site
1147161008872	oxalacetate/citrate binding site [chemical binding]; other site
1147161008873	coenzyme A binding site [chemical binding]; other site
1147161008874	catalytic triad [active]
1147161008875	Predicted membrane protein [Function unknown]; Region: COG2707
1147161008876	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
1147161008877	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147161008878	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1147161008879	pyruvate kinase; Provisional; Region: PRK06354
1147161008880	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1147161008881	domain interfaces; other site
1147161008882	active site
1147161008883	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1147161008884	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1147161008885	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1147161008886	active site
1147161008887	ADP/pyrophosphate binding site [chemical binding]; other site
1147161008888	dimerization interface [polypeptide binding]; other site
1147161008889	allosteric effector site; other site
1147161008890	fructose-1,6-bisphosphate binding site; other site
1147161008891	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1147161008892	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1147161008893	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1147161008894	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1147161008895	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1147161008896	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1147161008897	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1147161008898	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1147161008899	putative NAD(P) binding site [chemical binding]; other site
1147161008900	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
1147161008901	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1147161008902	active site
1147161008903	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1147161008904	generic binding surface I; other site
1147161008905	generic binding surface II; other site
1147161008906	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
1147161008907	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1147161008908	DHH family; Region: DHH; pfam01368
1147161008909	DHHA1 domain; Region: DHHA1; pfam02272
1147161008910	YtpI-like protein; Region: YtpI; pfam14007
1147161008911	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1147161008912	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161008913	DNA-binding site [nucleotide binding]; DNA binding site
1147161008914	DRTGG domain; Region: DRTGG; pfam07085
1147161008915	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1147161008916	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1147161008917	active site 2 [active]
1147161008918	active site 1 [active]
1147161008919	Predicted permeases [General function prediction only]; Region: COG0730
1147161008920	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1147161008921	amidohydrolase; Region: amidohydrolases; TIGR01891
1147161008922	metal binding site [ion binding]; metal-binding site
1147161008923	dimer interface [polypeptide binding]; other site
1147161008924	Riboflavin kinase; Region: Flavokinase; pfam01687
1147161008925	Riboflavin kinase; Region: Flavokinase; smart00904
1147161008926	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1147161008927	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1147161008928	active site
1147161008929	non-prolyl cis peptide bond; other site
1147161008930	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1147161008931	catalytic residues [active]
1147161008932	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1147161008933	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1147161008934	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1147161008935	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1147161008936	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1147161008937	Walker A/P-loop; other site
1147161008938	ATP binding site [chemical binding]; other site
1147161008939	Q-loop/lid; other site
1147161008940	ABC transporter signature motif; other site
1147161008941	Walker B; other site
1147161008942	D-loop; other site
1147161008943	H-loop/switch region; other site
1147161008944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161008945	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1147161008946	dimer interface [polypeptide binding]; other site
1147161008947	conserved gate region; other site
1147161008948	putative PBP binding loops; other site
1147161008949	ABC-ATPase subunit interface; other site
1147161008950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161008951	dimer interface [polypeptide binding]; other site
1147161008952	conserved gate region; other site
1147161008953	putative PBP binding loops; other site
1147161008954	ABC-ATPase subunit interface; other site
1147161008955	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1147161008956	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161008957	substrate binding pocket [chemical binding]; other site
1147161008958	membrane-bound complex binding site; other site
1147161008959	hinge residues; other site
1147161008960	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1147161008961	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161008962	substrate binding pocket [chemical binding]; other site
1147161008963	membrane-bound complex binding site; other site
1147161008964	hinge residues; other site
1147161008965	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1147161008966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161008967	Coenzyme A binding pocket [chemical binding]; other site
1147161008968	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161008969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161008970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161008971	dimerization interface [polypeptide binding]; other site
1147161008972	metal-dependent hydrolase; Provisional; Region: PRK00685
1147161008973	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1147161008974	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1147161008975	classical (c) SDRs; Region: SDR_c; cd05233
1147161008976	NAD(P) binding site [chemical binding]; other site
1147161008977	active site
1147161008978	argininosuccinate lyase; Provisional; Region: PRK00855
1147161008979	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1147161008980	active sites [active]
1147161008981	tetramer interface [polypeptide binding]; other site
1147161008982	argininosuccinate synthase; Provisional; Region: PRK13820
1147161008983	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1147161008984	ANP binding site [chemical binding]; other site
1147161008985	Substrate Binding Site II [chemical binding]; other site
1147161008986	Substrate Binding Site I [chemical binding]; other site
1147161008987	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1147161008988	MPT binding site; other site
1147161008989	trimer interface [polypeptide binding]; other site
1147161008990	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1147161008991	propionate/acetate kinase; Provisional; Region: PRK12379
1147161008992	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1147161008993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161008994	S-adenosylmethionine binding site [chemical binding]; other site
1147161008995	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1147161008996	dimer interface [polypeptide binding]; other site
1147161008997	catalytic triad [active]
1147161008998	peroxidatic and resolving cysteines [active]
1147161008999	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
1147161009000	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1147161009001	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1147161009002	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1147161009003	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1147161009004	tandem repeat interface [polypeptide binding]; other site
1147161009005	oligomer interface [polypeptide binding]; other site
1147161009006	active site residues [active]
1147161009007	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
1147161009008	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1147161009009	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1147161009010	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1147161009011	active site
1147161009012	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1147161009013	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
1147161009014	active site
1147161009015	acyl-activating enzyme (AAE) consensus motif; other site
1147161009016	putative CoA binding site [chemical binding]; other site
1147161009017	AMP binding site [chemical binding]; other site
1147161009018	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147161009019	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1147161009020	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1147161009021	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1147161009022	Ligand Binding Site [chemical binding]; other site
1147161009023	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1147161009024	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1147161009025	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161009026	catalytic residue [active]
1147161009027	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1147161009028	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1147161009029	histidinol-phosphatase; Reviewed; Region: PRK08123
1147161009030	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1147161009031	active site
1147161009032	dimer interface [polypeptide binding]; other site
1147161009033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161009034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161009035	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1147161009036	GAF domain; Region: GAF_2; pfam13185
1147161009037	GAF domain; Region: GAF; cl17456
1147161009038	GAF domain; Region: GAF_3; pfam13492
1147161009039	GAF domain; Region: GAF_2; pfam13185
1147161009040	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147161009041	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147161009042	metal binding site [ion binding]; metal-binding site
1147161009043	active site
1147161009044	I-site; other site
1147161009045	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1147161009046	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1147161009047	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161009048	RNA binding surface [nucleotide binding]; other site
1147161009049	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1147161009050	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1147161009051	active site
1147161009052	HIGH motif; other site
1147161009053	dimer interface [polypeptide binding]; other site
1147161009054	KMSKS motif; other site
1147161009055	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161009056	RNA binding surface [nucleotide binding]; other site
1147161009057	acetyl-CoA synthetase; Provisional; Region: PRK04319
1147161009058	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1147161009059	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1147161009060	active site
1147161009061	acyl-activating enzyme (AAE) consensus motif; other site
1147161009062	putative CoA binding site [chemical binding]; other site
1147161009063	AMP binding site [chemical binding]; other site
1147161009064	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161009065	Coenzyme A binding pocket [chemical binding]; other site
1147161009066	FOG: CBS domain [General function prediction only]; Region: COG0517
1147161009067	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
1147161009068	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
1147161009069	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1147161009070	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1147161009071	active site
1147161009072	Zn binding site [ion binding]; other site
1147161009073	flagellar motor protein MotS; Reviewed; Region: PRK06925
1147161009074	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1147161009075	ligand binding site [chemical binding]; other site
1147161009076	flagellar motor protein MotP; Reviewed; Region: PRK06926
1147161009077	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1147161009078	catabolite control protein A; Region: ccpA; TIGR01481
1147161009079	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161009080	DNA binding site [nucleotide binding]
1147161009081	domain linker motif; other site
1147161009082	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1147161009083	dimerization interface [polypeptide binding]; other site
1147161009084	effector binding site; other site
1147161009085	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1147161009086	chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801
1147161009087	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1147161009088	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1147161009089	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1147161009090	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1147161009091	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1147161009092	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1147161009093	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147161009094	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147161009095	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147161009096	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147161009097	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1147161009098	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1147161009099	putative tRNA-binding site [nucleotide binding]; other site
1147161009100	hypothetical protein; Provisional; Region: PRK13668
1147161009101	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161009102	catalytic residues [active]
1147161009103	YtoQ family protein; Region: YtoQ_fam; TIGR03646
1147161009104	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1147161009105	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1147161009106	oligomer interface [polypeptide binding]; other site
1147161009107	active site
1147161009108	metal binding site [ion binding]; metal-binding site
1147161009109	Predicted small secreted protein [Function unknown]; Region: COG5584
1147161009110	malate dehydrogenase; Provisional; Region: PRK13529
1147161009111	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1147161009112	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1147161009113	NAD(P) binding site [chemical binding]; other site
1147161009114	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161009115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161009116	S-adenosylmethionine binding site [chemical binding]; other site
1147161009117	YtzH-like protein; Region: YtzH; pfam14165
1147161009118	Phosphotransferase enzyme family; Region: APH; pfam01636
1147161009119	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1147161009120	substrate binding site [chemical binding]; other site
1147161009121	pullulanase, type I; Region: pulA_typeI; TIGR02104
1147161009122	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1147161009123	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1147161009124	Ca binding site [ion binding]; other site
1147161009125	active site
1147161009126	catalytic site [active]
1147161009127	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
1147161009128	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1147161009129	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1147161009130	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1147161009131	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1147161009132	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1147161009133	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1147161009134	dimer interface [polypeptide binding]; other site
1147161009135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161009136	catalytic residue [active]
1147161009137	dipeptidase PepV; Reviewed; Region: PRK07318
1147161009138	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1147161009139	active site
1147161009140	metal binding site [ion binding]; metal-binding site
1147161009141	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1147161009142	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1147161009143	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1147161009144	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161009145	Walker A/P-loop; other site
1147161009146	ATP binding site [chemical binding]; other site
1147161009147	Q-loop/lid; other site
1147161009148	ABC transporter signature motif; other site
1147161009149	Walker B; other site
1147161009150	D-loop; other site
1147161009151	H-loop/switch region; other site
1147161009152	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147161009153	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1147161009154	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1147161009155	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161009156	RNA binding surface [nucleotide binding]; other site
1147161009157	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1147161009158	active site
1147161009159	uracil binding [chemical binding]; other site
1147161009160	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1147161009161	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1147161009162	Predicted flavoproteins [General function prediction only]; Region: COG2081
1147161009163	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147161009164	BCCT family transporter; Region: BCCT; pfam02028
1147161009165	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
1147161009166	Predicted integral membrane protein [Function unknown]; Region: COG5578
1147161009167	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161009168	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161009169	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161009170	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1147161009171	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1147161009172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009173	dimer interface [polypeptide binding]; other site
1147161009174	conserved gate region; other site
1147161009175	ABC-ATPase subunit interface; other site
1147161009176	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1147161009177	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161009178	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147161009179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147161009180	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147161009181	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161009182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009183	dimer interface [polypeptide binding]; other site
1147161009184	conserved gate region; other site
1147161009185	putative PBP binding loops; other site
1147161009186	ABC-ATPase subunit interface; other site
1147161009187	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1147161009188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161009189	NAD(P) binding site [chemical binding]; other site
1147161009190	active site
1147161009191	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161009192	Cytochrome P450; Region: p450; cl12078
1147161009193	biotin synthase; Validated; Region: PRK06256
1147161009194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161009195	FeS/SAM binding site; other site
1147161009196	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1147161009197	AAA domain; Region: AAA_26; pfam13500
1147161009198	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147161009199	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1147161009200	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1147161009201	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1147161009202	substrate-cofactor binding pocket; other site
1147161009203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161009204	catalytic residue [active]
1147161009205	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
1147161009206	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161009207	inhibitor-cofactor binding pocket; inhibition site
1147161009208	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161009209	catalytic residue [active]
1147161009210	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1147161009211	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1147161009212	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1147161009213	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161009214	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161009215	DNA binding site [nucleotide binding]
1147161009216	domain linker motif; other site
1147161009217	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1147161009218	putative ligand binding site [chemical binding]; other site
1147161009219	putative dimerization interface [polypeptide binding]; other site
1147161009220	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161009221	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1147161009222	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1147161009223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009224	dimer interface [polypeptide binding]; other site
1147161009225	conserved gate region; other site
1147161009226	putative PBP binding loops; other site
1147161009227	ABC-ATPase subunit interface; other site
1147161009228	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161009229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009230	dimer interface [polypeptide binding]; other site
1147161009231	conserved gate region; other site
1147161009232	putative PBP binding loops; other site
1147161009233	ABC-ATPase subunit interface; other site
1147161009234	alpha-galactosidase; Provisional; Region: PRK15076
1147161009235	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1147161009236	NAD binding site [chemical binding]; other site
1147161009237	sugar binding site [chemical binding]; other site
1147161009238	divalent metal binding site [ion binding]; other site
1147161009239	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161009240	dimer interface [polypeptide binding]; other site
1147161009241	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1147161009242	active site residue [active]
1147161009243	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1147161009244	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1147161009245	HIGH motif; other site
1147161009246	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1147161009247	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1147161009248	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1147161009249	active site
1147161009250	KMSKS motif; other site
1147161009251	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1147161009252	tRNA binding surface [nucleotide binding]; other site
1147161009253	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
1147161009254	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161009255	PAS domain; Region: PAS_9; pfam13426
1147161009256	putative active site [active]
1147161009257	heme pocket [chemical binding]; other site
1147161009258	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1147161009259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161009260	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161009261	putative substrate translocation pore; other site
1147161009262	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1147161009263	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1147161009264	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147161009265	FtsX-like permease family; Region: FtsX; pfam02687
1147161009266	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147161009267	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161009268	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161009269	Walker A/P-loop; other site
1147161009270	ATP binding site [chemical binding]; other site
1147161009271	Q-loop/lid; other site
1147161009272	ABC transporter signature motif; other site
1147161009273	Walker B; other site
1147161009274	D-loop; other site
1147161009275	H-loop/switch region; other site
1147161009276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161009277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161009278	ATP binding site [chemical binding]; other site
1147161009279	Mg2+ binding site [ion binding]; other site
1147161009280	G-X-G motif; other site
1147161009281	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161009282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161009283	active site
1147161009284	phosphorylation site [posttranslational modification]
1147161009285	intermolecular recognition site; other site
1147161009286	dimerization interface [polypeptide binding]; other site
1147161009287	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161009288	DNA binding site [nucleotide binding]
1147161009289	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1147161009290	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147161009291	FtsX-like permease family; Region: FtsX; pfam02687
1147161009292	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161009293	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161009294	Walker A/P-loop; other site
1147161009295	ATP binding site [chemical binding]; other site
1147161009296	Q-loop/lid; other site
1147161009297	ABC transporter signature motif; other site
1147161009298	Walker B; other site
1147161009299	D-loop; other site
1147161009300	H-loop/switch region; other site
1147161009301	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147161009302	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147161009303	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161009304	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161009305	Walker A/P-loop; other site
1147161009306	ATP binding site [chemical binding]; other site
1147161009307	Q-loop/lid; other site
1147161009308	ABC transporter signature motif; other site
1147161009309	Walker B; other site
1147161009310	D-loop; other site
1147161009311	H-loop/switch region; other site
1147161009312	Predicted transcriptional regulators [Transcription]; Region: COG1725
1147161009313	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161009314	DNA-binding site [nucleotide binding]; DNA binding site
1147161009315	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
1147161009316	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1147161009317	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1147161009318	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
1147161009319	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1147161009320	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147161009321	PGAP1-like protein; Region: PGAP1; pfam07819
1147161009322	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1147161009323	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1147161009324	trimer interface [polypeptide binding]; other site
1147161009325	putative metal binding site [ion binding]; other site
1147161009326	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1147161009327	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1147161009328	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1147161009329	active site
1147161009330	dimer interface [polypeptide binding]; other site
1147161009331	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1147161009332	Ligand Binding Site [chemical binding]; other site
1147161009333	Molecular Tunnel; other site
1147161009334	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1147161009335	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1147161009336	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1147161009337	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1147161009338	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1147161009339	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1147161009340	active site
1147161009341	substrate-binding site [chemical binding]; other site
1147161009342	metal-binding site [ion binding]
1147161009343	ATP binding site [chemical binding]; other site
1147161009344	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
1147161009345	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1147161009346	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1147161009347	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1147161009348	NMT1-like family; Region: NMT1_2; pfam13379
1147161009349	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1147161009350	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1147161009351	Walker A/P-loop; other site
1147161009352	ATP binding site [chemical binding]; other site
1147161009353	Q-loop/lid; other site
1147161009354	ABC transporter signature motif; other site
1147161009355	Walker B; other site
1147161009356	D-loop; other site
1147161009357	H-loop/switch region; other site
1147161009358	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1147161009359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009360	dimer interface [polypeptide binding]; other site
1147161009361	conserved gate region; other site
1147161009362	putative PBP binding loops; other site
1147161009363	ABC-ATPase subunit interface; other site
1147161009364	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1147161009365	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1147161009366	nudix motif; other site
1147161009367	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
1147161009368	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1147161009369	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1147161009370	dimerization interface [polypeptide binding]; other site
1147161009371	DPS ferroxidase diiron center [ion binding]; other site
1147161009372	ion pore; other site
1147161009373	YtkA-like; Region: YtkA; pfam13115
1147161009374	S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664
1147161009375	Haemolytic domain; Region: Haemolytic; pfam01809
1147161009376	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1147161009377	active site clefts [active]
1147161009378	zinc binding site [ion binding]; other site
1147161009379	dimer interface [polypeptide binding]; other site
1147161009380	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1147161009381	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1147161009382	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1147161009383	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1147161009384	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1147161009385	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161009386	ABC-ATPase subunit  interface; other site
1147161009387	dimer interface [polypeptide binding]; other site
1147161009388	putative PBP binding regions; other site
1147161009389	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1147161009390	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161009391	ABC-ATPase subunit  interface; other site
1147161009392	dimer interface [polypeptide binding]; other site
1147161009393	putative PBP binding regions; other site
1147161009394	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1147161009395	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1147161009396	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1147161009397	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1147161009398	Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species.  The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016
1147161009399	metal binding site [ion binding]; metal-binding site
1147161009400	intersubunit interface [polypeptide binding]; other site
1147161009401	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
1147161009402	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1147161009403	active site
1147161009404	octamer interface [polypeptide binding]; other site
1147161009405	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1147161009406	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1147161009407	acyl-activating enzyme (AAE) consensus motif; other site
1147161009408	putative AMP binding site [chemical binding]; other site
1147161009409	putative active site [active]
1147161009410	putative CoA binding site [chemical binding]; other site
1147161009411	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161009412	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1147161009413	substrate binding site [chemical binding]; other site
1147161009414	oxyanion hole (OAH) forming residues; other site
1147161009415	trimer interface [polypeptide binding]; other site
1147161009416	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1147161009417	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1147161009418	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1147161009419	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1147161009420	dimer interface [polypeptide binding]; other site
1147161009421	tetramer interface [polypeptide binding]; other site
1147161009422	PYR/PP interface [polypeptide binding]; other site
1147161009423	TPP binding site [chemical binding]; other site
1147161009424	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1147161009425	TPP-binding site; other site
1147161009426	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1147161009427	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1147161009428	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
1147161009429	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1147161009430	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1147161009431	active site
1147161009432	tetramer interface; other site
1147161009433	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1147161009434	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1147161009435	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1147161009436	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1147161009437	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1147161009438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161009439	NAD(P) binding site [chemical binding]; other site
1147161009440	active site
1147161009441	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161009442	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1147161009443	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
1147161009444	spore coat protein YutH; Region: spore_yutH; TIGR02905
1147161009445	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161009446	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1147161009447	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
1147161009448	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
1147161009449	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
1147161009450	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1147161009451	homodimer interface [polypeptide binding]; other site
1147161009452	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1147161009453	active site pocket [active]
1147161009454	glycogen synthase; Provisional; Region: glgA; PRK00654
1147161009455	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1147161009456	ADP-binding pocket [chemical binding]; other site
1147161009457	homodimer interface [polypeptide binding]; other site
1147161009458	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1147161009459	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1147161009460	ligand binding site; other site
1147161009461	oligomer interface; other site
1147161009462	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1147161009463	dimer interface [polypeptide binding]; other site
1147161009464	N-terminal domain interface [polypeptide binding]; other site
1147161009465	sulfate 1 binding site; other site
1147161009466	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1147161009467	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1147161009468	ligand binding site; other site
1147161009469	oligomer interface; other site
1147161009470	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1147161009471	dimer interface [polypeptide binding]; other site
1147161009472	N-terminal domain interface [polypeptide binding]; other site
1147161009473	sulfate 1 binding site; other site
1147161009474	alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515
1147161009475	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1147161009476	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1147161009477	active site
1147161009478	catalytic site [active]
1147161009479	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1147161009480	Predicted membrane protein [Function unknown]; Region: COG3859
1147161009481	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1147161009482	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161009483	Coenzyme A binding pocket [chemical binding]; other site
1147161009484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1147161009485	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1147161009486	DinB superfamily; Region: DinB_2; pfam12867
1147161009487	MOSC domain; Region: MOSC; pfam03473
1147161009488	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1147161009489	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1147161009490	active site
1147161009491	NAD binding site [chemical binding]; other site
1147161009492	metal binding site [ion binding]; metal-binding site
1147161009493	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1147161009494	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1147161009495	tetramerization interface [polypeptide binding]; other site
1147161009496	NAD(P) binding site [chemical binding]; other site
1147161009497	catalytic residues [active]
1147161009498	Predicted transcriptional regulators [Transcription]; Region: COG1510
1147161009499	MarR family; Region: MarR_2; pfam12802
1147161009500	ydaO-yuaA; BSU6051_3108010
1147161009501	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1147161009502	TrkA-N domain; Region: TrkA_N; pfam02254
1147161009503	TrkA-C domain; Region: TrkA_C; pfam02080
1147161009504	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1147161009505	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1147161009506	Predicted membrane protein [Function unknown]; Region: COG4682
1147161009507	yiaA/B two helix domain; Region: YiaAB; pfam05360
1147161009508	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1147161009509	SH3-like domain; Region: SH3_8; pfam13457
1147161009510	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161009511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161009512	putative substrate translocation pore; other site
1147161009513	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1147161009514	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
1147161009515	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147161009516	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1147161009517	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161009518	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161009519	L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134
1147161009520	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1147161009521	Domain of unknown function (DUF718); Region: DUF718; cl01281
1147161009522	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1147161009523	N- and C-terminal domain interface [polypeptide binding]; other site
1147161009524	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1147161009525	active site
1147161009526	putative catalytic site [active]
1147161009527	metal binding site [ion binding]; metal-binding site
1147161009528	ATP binding site [chemical binding]; other site
1147161009529	carbohydrate binding site [chemical binding]; other site
1147161009530	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147161009531	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1147161009532	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1147161009533	short chain dehydrogenase; Validated; Region: PRK08324
1147161009534	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1147161009535	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
1147161009536	putative NAD(P) binding site [chemical binding]; other site
1147161009537	active site
1147161009538	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
1147161009539	Cache domain; Region: Cache_1; pfam02743
1147161009540	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161009541	dimerization interface [polypeptide binding]; other site
1147161009542	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147161009543	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161009544	dimer interface [polypeptide binding]; other site
1147161009545	putative CheW interface [polypeptide binding]; other site
1147161009546	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161009547	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
1147161009548	Cache domain; Region: Cache_1; pfam02743
1147161009549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161009550	dimerization interface [polypeptide binding]; other site
1147161009551	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161009552	dimer interface [polypeptide binding]; other site
1147161009553	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1147161009554	putative CheW interface [polypeptide binding]; other site
1147161009555	Tar ligand binding domain homologue; Region: TarH; pfam02203
1147161009556	Cache domain; Region: Cache_1; pfam02743
1147161009557	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1147161009558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161009559	dimerization interface [polypeptide binding]; other site
1147161009560	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161009561	dimer interface [polypeptide binding]; other site
1147161009562	putative CheW interface [polypeptide binding]; other site
1147161009563	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
1147161009564	Cache domain; Region: Cache_1; pfam02743
1147161009565	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161009566	dimerization interface [polypeptide binding]; other site
1147161009567	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147161009568	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161009569	dimer interface [polypeptide binding]; other site
1147161009570	putative CheW interface [polypeptide binding]; other site
1147161009571	transglutaminase; Provisional; Region: tgl; PRK03187
1147161009572	secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ
1147161009573	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1147161009574	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1147161009575	Ca binding site [ion binding]; other site
1147161009576	active site
1147161009577	catalytic site [active]
1147161009578	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1147161009579	Domain of unknown function DUF21; Region: DUF21; pfam01595
1147161009580	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1147161009581	Transporter associated domain; Region: CorC_HlyC; smart01091
1147161009582	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1147161009583	Membrane-integrating protein Mistic; Region: Mistic; pfam11458
1147161009584	Ion channel; Region: Ion_trans_2; pfam07885
1147161009585	TrkA-N domain; Region: TrkA_N; pfam02254
1147161009586	YugN-like family; Region: YugN; pfam08868
1147161009587	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1147161009588	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1147161009589	active site
1147161009590	dimer interface [polypeptide binding]; other site
1147161009591	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1147161009592	dimer interface [polypeptide binding]; other site
1147161009593	active site
1147161009594	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1147161009595	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1147161009596	dimer interface [polypeptide binding]; other site
1147161009597	active site
1147161009598	metal binding site [ion binding]; metal-binding site
1147161009599	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1147161009600	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1147161009601	dimer interface [polypeptide binding]; other site
1147161009602	active site
1147161009603	metal binding site [ion binding]; metal-binding site
1147161009604	Uncharacterized conserved protein [Function unknown]; Region: COG2155
1147161009605	general stress protein 13; Validated; Region: PRK08059
1147161009606	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1147161009607	RNA binding site [nucleotide binding]; other site
1147161009608	hypothetical protein; Validated; Region: PRK07682
1147161009609	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161009610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161009611	homodimer interface [polypeptide binding]; other site
1147161009612	catalytic residue [active]
1147161009613	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1147161009614	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161009615	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161009616	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1147161009617	nucleophilic elbow; other site
1147161009618	catalytic triad; other site
1147161009619	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
1147161009620	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1147161009621	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161009622	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161009623	homodimer interface [polypeptide binding]; other site
1147161009624	catalytic residue [active]
1147161009625	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161009626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161009627	dimer interface [polypeptide binding]; other site
1147161009628	phosphorylation site [posttranslational modification]
1147161009629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161009630	ATP binding site [chemical binding]; other site
1147161009631	Mg2+ binding site [ion binding]; other site
1147161009632	G-X-G motif; other site
1147161009633	Kinase associated protein B; Region: KapB; pfam08810
1147161009634	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1147161009635	active site
1147161009636	catalytic site [active]
1147161009637	substrate binding site [chemical binding]; other site
1147161009638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161009639	drug efflux system protein MdtG; Provisional; Region: PRK09874
1147161009640	putative substrate translocation pore; other site
1147161009641	Transglycosylase; Region: Transgly; pfam00912
1147161009642	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1147161009643	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1147161009644	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1147161009645	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1147161009646	PAS domain; Region: PAS; smart00091
1147161009647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161009648	ATP binding site [chemical binding]; other site
1147161009649	G-X-G motif; other site
1147161009650	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1147161009651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161009652	active site
1147161009653	phosphorylation site [posttranslational modification]
1147161009654	intermolecular recognition site; other site
1147161009655	dimerization interface [polypeptide binding]; other site
1147161009656	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1147161009657	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1147161009658	ligand binding site [chemical binding]; other site
1147161009659	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1147161009660	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1147161009661	Walker A/P-loop; other site
1147161009662	ATP binding site [chemical binding]; other site
1147161009663	Q-loop/lid; other site
1147161009664	ABC transporter signature motif; other site
1147161009665	Walker B; other site
1147161009666	D-loop; other site
1147161009667	H-loop/switch region; other site
1147161009668	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1147161009669	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1147161009670	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1147161009671	TM-ABC transporter signature motif; other site
1147161009672	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1147161009673	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1147161009674	TM-ABC transporter signature motif; other site
1147161009675	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1147161009676	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1147161009677	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147161009678	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1147161009679	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1147161009680	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
1147161009681	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1147161009682	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147161009683	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
1147161009684	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
1147161009685	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1147161009686	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1147161009687	CoenzymeA binding site [chemical binding]; other site
1147161009688	subunit interaction site [polypeptide binding]; other site
1147161009689	PHB binding site; other site
1147161009690	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161009691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161009692	active site
1147161009693	phosphorylation site [posttranslational modification]
1147161009694	intermolecular recognition site; other site
1147161009695	dimerization interface [polypeptide binding]; other site
1147161009696	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161009697	DNA binding residues [nucleotide binding]
1147161009698	dimerization interface [polypeptide binding]; other site
1147161009699	Bacillus competence pheromone ComX; Region: ComX; pfam05952
1147161009700	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1147161009701	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1147161009702	substrate binding pocket [chemical binding]; other site
1147161009703	substrate-Mg2+ binding site; other site
1147161009704	aspartate-rich region 1; other site
1147161009705	DegQ (SacQ) family; Region: DegQ; pfam08181
1147161009706	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1147161009707	EAL domain; Region: EAL; pfam00563
1147161009708	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1147161009709	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1147161009710	active site
1147161009711	Isochorismatase family; Region: Isochorismatase; pfam00857
1147161009712	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1147161009713	catalytic triad [active]
1147161009714	conserved cis-peptide bond; other site
1147161009715	Uncharacterized conserved protein [Function unknown]; Region: COG5506
1147161009716	YueH-like protein; Region: YueH; pfam14166
1147161009717	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1147161009718	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1147161009719	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147161009720	Uncharacterized conserved small protein [Function unknown]; Region: COG5428
1147161009721	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
1147161009722	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1147161009723	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161009724	Zn2+ binding site [ion binding]; other site
1147161009725	Mg2+ binding site [ion binding]; other site
1147161009726	short chain dehydrogenase; Provisional; Region: PRK06924
1147161009727	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
1147161009728	NADP binding site [chemical binding]; other site
1147161009729	homodimer interface [polypeptide binding]; other site
1147161009730	active site
1147161009731	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
1147161009732	Predicted membrane protein [Function unknown]; Region: COG1511
1147161009733	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1147161009734	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1147161009735	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
1147161009736	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1147161009737	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1147161009738	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147161009739	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147161009740	Domain of unknown function DUF87; Region: DUF87; pfam01935
1147161009741	Predicted membrane protein [Function unknown]; Region: COG4499
1147161009742	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1147161009743	Uncharacterized small protein [Function unknown]; Region: COG5417
1147161009744	Ubiquitin homologues; Region: UBQ; smart00213
1147161009745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1147161009746	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1147161009747	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147161009748	alanine dehydrogenase; Region: alaDH; TIGR00518
1147161009749	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1147161009750	hexamer interface [polypeptide binding]; other site
1147161009751	ligand binding site [chemical binding]; other site
1147161009752	putative active site [active]
1147161009753	NAD(P) binding site [chemical binding]; other site
1147161009754	Uncharacterized conserved protein [Function unknown]; Region: COG5634
1147161009755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1147161009756	Condensation domain; Region: Condensation; pfam00668
1147161009757	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147161009758	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1147161009759	acyl-activating enzyme (AAE) consensus motif; other site
1147161009760	AMP binding site [chemical binding]; other site
1147161009761	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161009762	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1147161009763	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147161009764	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147161009765	acyl-activating enzyme (AAE) consensus motif; other site
1147161009766	AMP binding site [chemical binding]; other site
1147161009767	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147161009768	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1147161009769	hydrophobic substrate binding pocket; other site
1147161009770	Isochorismatase family; Region: Isochorismatase; pfam00857
1147161009771	active site
1147161009772	conserved cis-peptide bond; other site
1147161009773	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1147161009774	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
1147161009775	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1147161009776	acyl-activating enzyme (AAE) consensus motif; other site
1147161009777	active site
1147161009778	AMP binding site [chemical binding]; other site
1147161009779	substrate binding site [chemical binding]; other site
1147161009780	isochorismate synthase DhbC; Validated; Region: PRK06923
1147161009781	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1147161009782	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1147161009783	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1147161009784	putative NAD(P) binding site [chemical binding]; other site
1147161009785	active site
1147161009786	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1147161009787	Putative esterase; Region: Esterase; pfam00756
1147161009788	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1147161009789	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1147161009790	Moco binding site; other site
1147161009791	metal coordination site [ion binding]; other site
1147161009792	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1147161009793	Predicted permease [General function prediction only]; Region: COG2056
1147161009794	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1147161009795	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1147161009796	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1147161009797	interface (dimer of trimers) [polypeptide binding]; other site
1147161009798	Substrate-binding/catalytic site; other site
1147161009799	Zn-binding sites [ion binding]; other site
1147161009800	Divergent PAP2 family; Region: DUF212; pfam02681
1147161009801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1147161009802	Putative membrane protein; Region: YuiB; pfam14068
1147161009803	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
1147161009804	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1147161009805	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161009806	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1147161009807	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147161009808	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161009809	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1147161009810	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1147161009811	active site
1147161009812	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
1147161009813	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1147161009814	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161009815	Coenzyme A binding pocket [chemical binding]; other site
1147161009816	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1147161009817	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1147161009818	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1147161009819	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1147161009820	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1147161009821	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1147161009822	Nucleoside recognition; Region: Gate; pfam07670
1147161009823	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1147161009824	hypothetical protein; Provisional; Region: PRK13669
1147161009825	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1147161009826	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161009827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
1147161009828	NifU-like domain; Region: NifU; pfam01106
1147161009829	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1147161009830	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1147161009831	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1147161009832	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1147161009833	homoserine kinase; Region: thrB; TIGR00191
1147161009834	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1147161009835	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1147161009836	threonine synthase; Reviewed; Region: PRK06721
1147161009837	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1147161009838	homodimer interface [polypeptide binding]; other site
1147161009839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161009840	catalytic residue [active]
1147161009841	homoserine dehydrogenase; Provisional; Region: PRK06349
1147161009842	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1147161009843	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1147161009844	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1147161009845	spore coat protein YutH; Region: spore_yutH; TIGR02905
1147161009846	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1147161009847	tetramer interfaces [polypeptide binding]; other site
1147161009848	binuclear metal-binding site [ion binding]; other site
1147161009849	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1147161009850	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161009851	active site
1147161009852	motif I; other site
1147161009853	motif II; other site
1147161009854	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161009855	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1147161009856	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1147161009857	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1147161009858	lipoyl synthase; Provisional; Region: PRK05481
1147161009859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161009860	FeS/SAM binding site; other site
1147161009861	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147161009862	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147161009863	sporulation protein YunB; Region: spo_yunB; TIGR02832
1147161009864	Uncharacterized conserved protein [Function unknown]; Region: COG3377
1147161009865	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1147161009866	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1147161009867	active site
1147161009868	metal binding site [ion binding]; metal-binding site
1147161009869	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1147161009870	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1147161009871	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1147161009872	allantoinase; Provisional; Region: PRK06189
1147161009873	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1147161009874	active site
1147161009875	DRTGG domain; Region: DRTGG; pfam07085
1147161009876	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1147161009877	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147161009878	xanthine permease; Region: pbuX; TIGR03173
1147161009879	xanthine permease; Region: pbuX; TIGR03173
1147161009880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
1147161009881	Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648
1147161009882	Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445
1147161009883	tetramer interface [polypeptide binding]; other site
1147161009884	active site
1147161009885	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cd05469
1147161009886	active site
1147161009887	homotetramer interface [polypeptide binding]; other site
1147161009888	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
1147161009889	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1147161009890	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1147161009891	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
1147161009892	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1147161009893	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1147161009894	xanthine dehydrogenase C subunit; Region: pucC; TIGR03199
1147161009895	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1147161009896	Ligand binding site; other site
1147161009897	metal-binding site
1147161009898	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1147161009899	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1147161009900	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1147161009901	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1147161009902	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161009903	catalytic residue [active]
1147161009904	allantoate amidohydrolase; Reviewed; Region: PRK09290
1147161009905	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1147161009906	active site
1147161009907	metal binding site [ion binding]; metal-binding site
1147161009908	dimer interface [polypeptide binding]; other site
1147161009909	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
1147161009910	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1147161009911	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1147161009912	Walker A/P-loop; other site
1147161009913	ATP binding site [chemical binding]; other site
1147161009914	Q-loop/lid; other site
1147161009915	ABC transporter signature motif; other site
1147161009916	Walker B; other site
1147161009917	D-loop; other site
1147161009918	H-loop/switch region; other site
1147161009919	TOBE domain; Region: TOBE_2; pfam08402
1147161009920	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
1147161009921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161009922	DNA-binding site [nucleotide binding]; DNA binding site
1147161009923	UTRA domain; Region: UTRA; pfam07702
1147161009924	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1147161009925	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
1147161009926	substrate binding site [chemical binding]; other site
1147161009927	ATP binding site [chemical binding]; other site
1147161009928	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161009929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009930	dimer interface [polypeptide binding]; other site
1147161009931	conserved gate region; other site
1147161009932	putative PBP binding loops; other site
1147161009933	ABC-ATPase subunit interface; other site
1147161009934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009935	dimer interface [polypeptide binding]; other site
1147161009936	conserved gate region; other site
1147161009937	putative PBP binding loops; other site
1147161009938	ABC-ATPase subunit interface; other site
1147161009939	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147161009940	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161009941	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1147161009942	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1147161009943	putative active site [active]
1147161009944	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1147161009945	dimer interface [polypeptide binding]; other site
1147161009946	active site
1147161009947	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
1147161009948	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1147161009949	GIY-YIG motif/motif A; other site
1147161009950	active site
1147161009951	catalytic site [active]
1147161009952	putative DNA binding site [nucleotide binding]; other site
1147161009953	metal binding site [ion binding]; metal-binding site
1147161009954	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1147161009955	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1147161009956	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161009957	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1147161009958	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161009959	dimerization interface [polypeptide binding]; other site
1147161009960	putative DNA binding site [nucleotide binding]; other site
1147161009961	putative Zn2+ binding site [ion binding]; other site
1147161009962	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1147161009963	FeS assembly protein SufB; Region: sufB; TIGR01980
1147161009964	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1147161009965	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1147161009966	trimerization site [polypeptide binding]; other site
1147161009967	active site
1147161009968	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1147161009969	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1147161009970	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147161009971	catalytic residue [active]
1147161009972	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1147161009973	FeS assembly protein SufD; Region: sufD; TIGR01981
1147161009974	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1147161009975	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1147161009976	Walker A/P-loop; other site
1147161009977	ATP binding site [chemical binding]; other site
1147161009978	Q-loop/lid; other site
1147161009979	ABC transporter signature motif; other site
1147161009980	Walker B; other site
1147161009981	D-loop; other site
1147161009982	H-loop/switch region; other site
1147161009983	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1147161009984	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1147161009985	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1147161009986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161009987	conserved gate region; other site
1147161009988	ABC-ATPase subunit interface; other site
1147161009989	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1147161009990	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1147161009991	Walker A/P-loop; other site
1147161009992	ATP binding site [chemical binding]; other site
1147161009993	Q-loop/lid; other site
1147161009994	ABC transporter signature motif; other site
1147161009995	Walker B; other site
1147161009996	D-loop; other site
1147161009997	H-loop/switch region; other site
1147161009998	NIL domain; Region: NIL; pfam09383
1147161009999	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1147161010000	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147161010001	catalytic residues [active]
1147161010002	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1147161010003	putative active site [active]
1147161010004	putative metal binding site [ion binding]; other site
1147161010005	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
1147161010006	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1147161010007	lipoyl attachment site [posttranslational modification]; other site
1147161010008	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1147161010009	ArsC family; Region: ArsC; pfam03960
1147161010010	putative ArsC-like catalytic residues; other site
1147161010011	putative TRX-like catalytic residues [active]
1147161010012	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1147161010013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1147161010014	active site
1147161010015	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1147161010016	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1147161010017	dimer interface [polypeptide binding]; other site
1147161010018	active site
1147161010019	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1147161010020	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1147161010021	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1147161010022	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1147161010023	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1147161010024	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147161010025	substrate binding site [chemical binding]; other site
1147161010026	oxyanion hole (OAH) forming residues; other site
1147161010027	trimer interface [polypeptide binding]; other site
1147161010028	Proline dehydrogenase; Region: Pro_dh; pfam01619
1147161010029	Coat F domain; Region: Coat_F; pfam07875
1147161010030	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161010031	MarR family; Region: MarR; pfam01047
1147161010032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161010033	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161010034	putative substrate translocation pore; other site
1147161010035	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1147161010036	classical (c) SDRs; Region: SDR_c; cd05233
1147161010037	active site
1147161010038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147161010039	NAD(P) binding site [chemical binding]; other site
1147161010040	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161010041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161010042	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1147161010043	dimerization interface [polypeptide binding]; other site
1147161010044	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
1147161010045	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147161010046	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1147161010047	Walker A/P-loop; other site
1147161010048	ATP binding site [chemical binding]; other site
1147161010049	Q-loop/lid; other site
1147161010050	ABC transporter signature motif; other site
1147161010051	Walker B; other site
1147161010052	D-loop; other site
1147161010053	H-loop/switch region; other site
1147161010054	YusW-like protein; Region: YusW; pfam14039
1147161010055	short chain dehydrogenase; Provisional; Region: PRK06914
1147161010056	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1147161010057	NADP binding site [chemical binding]; other site
1147161010058	active site
1147161010059	steroid binding site; other site
1147161010060	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1147161010061	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1147161010062	dimerization interface [polypeptide binding]; other site
1147161010063	DPS ferroxidase diiron center [ion binding]; other site
1147161010064	ion pore; other site
1147161010065	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1147161010066	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1147161010067	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1147161010068	protein binding site [polypeptide binding]; other site
1147161010069	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161010070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161010071	active site
1147161010072	phosphorylation site [posttranslational modification]
1147161010073	intermolecular recognition site; other site
1147161010074	dimerization interface [polypeptide binding]; other site
1147161010075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161010076	DNA binding site [nucleotide binding]
1147161010077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161010078	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161010079	dimerization interface [polypeptide binding]; other site
1147161010080	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161010081	dimer interface [polypeptide binding]; other site
1147161010082	phosphorylation site [posttranslational modification]
1147161010083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161010084	ATP binding site [chemical binding]; other site
1147161010085	Mg2+ binding site [ion binding]; other site
1147161010086	G-X-G motif; other site
1147161010087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161010088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161010089	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1147161010090	Class II fumarases; Region: Fumarase_classII; cd01362
1147161010091	active site
1147161010092	tetramer interface [polypeptide binding]; other site
1147161010093	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
1147161010094	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147161010095	Spore germination protein; Region: Spore_permease; pfam03845
1147161010096	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147161010097	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147161010098	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161010099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161010100	active site
1147161010101	phosphorylation site [posttranslational modification]
1147161010102	intermolecular recognition site; other site
1147161010103	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161010104	DNA binding residues [nucleotide binding]
1147161010105	dimerization interface [polypeptide binding]; other site
1147161010106	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161010107	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161010108	dimerization interface [polypeptide binding]; other site
1147161010109	Histidine kinase; Region: HisKA_3; pfam07730
1147161010110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161010111	ATP binding site [chemical binding]; other site
1147161010112	Mg2+ binding site [ion binding]; other site
1147161010113	G-X-G motif; other site
1147161010114	Predicted membrane protein [Function unknown]; Region: COG4758
1147161010115	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
1147161010116	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1147161010117	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1147161010118	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1147161010119	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1147161010120	PspA/IM30 family; Region: PspA_IM30; pfam04012
1147161010121	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147161010122	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
1147161010123	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147161010124	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1147161010125	Walker A/P-loop; other site
1147161010126	ATP binding site [chemical binding]; other site
1147161010127	Q-loop/lid; other site
1147161010128	ABC transporter signature motif; other site
1147161010129	Walker B; other site
1147161010130	D-loop; other site
1147161010131	H-loop/switch region; other site
1147161010132	Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865
1147161010133	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1147161010134	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161010135	ABC-ATPase subunit  interface; other site
1147161010136	dimer interface [polypeptide binding]; other site
1147161010137	putative PBP binding regions; other site
1147161010138	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1147161010139	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1147161010140	putative binding site residues; other site
1147161010141	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1147161010142	classical (c) SDRs; Region: SDR_c; cd05233
1147161010143	NAD(P) binding site [chemical binding]; other site
1147161010144	active site
1147161010145	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1147161010146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161010147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161010148	dimer interface [polypeptide binding]; other site
1147161010149	phosphorylation site [posttranslational modification]
1147161010150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161010151	ATP binding site [chemical binding]; other site
1147161010152	Mg2+ binding site [ion binding]; other site
1147161010153	G-X-G motif; other site
1147161010154	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161010155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161010156	active site
1147161010157	phosphorylation site [posttranslational modification]
1147161010158	intermolecular recognition site; other site
1147161010159	dimerization interface [polypeptide binding]; other site
1147161010160	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161010161	DNA binding site [nucleotide binding]
1147161010162	hypothetical protein; Provisional; Region: PRK14082
1147161010163	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147161010164	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161010165	DNA binding residues [nucleotide binding]
1147161010166	YvrJ protein family; Region: YvrJ; pfam12841
1147161010167	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
1147161010168	Cupin; Region: Cupin_1; smart00835
1147161010169	Cupin; Region: Cupin_1; smart00835
1147161010170	Regulatory protein YrvL; Region: YrvL; pfam14184
1147161010171	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1147161010172	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147161010173	FtsX-like permease family; Region: FtsX; pfam02687
1147161010174	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161010175	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161010176	Walker A/P-loop; other site
1147161010177	ATP binding site [chemical binding]; other site
1147161010178	Q-loop/lid; other site
1147161010179	ABC transporter signature motif; other site
1147161010180	Walker B; other site
1147161010181	D-loop; other site
1147161010182	H-loop/switch region; other site
1147161010183	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1147161010184	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1147161010185	DNA damage checkpoint protein; Region: LCD1; pfam09798
1147161010186	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147161010187	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147161010188	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1147161010189	Walker A/P-loop; other site
1147161010190	ATP binding site [chemical binding]; other site
1147161010191	Q-loop/lid; other site
1147161010192	ABC transporter signature motif; other site
1147161010193	Walker B; other site
1147161010194	D-loop; other site
1147161010195	H-loop/switch region; other site
1147161010196	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1147161010197	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161010198	ABC-ATPase subunit  interface; other site
1147161010199	dimer interface [polypeptide binding]; other site
1147161010200	putative PBP binding regions; other site
1147161010201	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1147161010202	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147161010203	ABC-ATPase subunit  interface; other site
1147161010204	dimer interface [polypeptide binding]; other site
1147161010205	putative PBP binding regions; other site
1147161010206	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1147161010207	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1147161010208	putative ligand binding residues [chemical binding]; other site
1147161010209	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1147161010210	small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863
1147161010211	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1147161010212	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1147161010213	Sulfatase; Region: Sulfatase; pfam00884
1147161010214	DNA binding domain, excisionase family; Region: excise; TIGR01764
1147161010215	Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910
1147161010216	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1147161010217	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1147161010218	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1147161010219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010220	dimer interface [polypeptide binding]; other site
1147161010221	conserved gate region; other site
1147161010222	putative PBP binding loops; other site
1147161010223	ABC-ATPase subunit interface; other site
1147161010224	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161010225	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161010226	active site
1147161010227	catalytic tetrad [active]
1147161010228	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1147161010229	sulfite reductase subunit beta; Provisional; Region: PRK13504
1147161010230	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1147161010231	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1147161010232	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
1147161010233	Flavodoxin; Region: Flavodoxin_1; pfam00258
1147161010234	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1147161010235	FAD binding pocket [chemical binding]; other site
1147161010236	FAD binding motif [chemical binding]; other site
1147161010237	catalytic residues [active]
1147161010238	NAD binding pocket [chemical binding]; other site
1147161010239	phosphate binding motif [ion binding]; other site
1147161010240	beta-alpha-beta structure motif; other site
1147161010241	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1147161010242	Part of AAA domain; Region: AAA_19; pfam13245
1147161010243	Family description; Region: UvrD_C_2; pfam13538
1147161010244	Predicted membrane protein [Function unknown]; Region: COG2860
1147161010245	UPF0126 domain; Region: UPF0126; pfam03458
1147161010246	UPF0126 domain; Region: UPF0126; pfam03458
1147161010247	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1147161010248	Thioredoxin; Region: Thioredoxin_4; pfam13462
1147161010249	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1147161010250	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147161010251	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147161010252	metal-binding site [ion binding]
1147161010253	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147161010254	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1147161010255	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147161010256	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147161010257	metal-binding site [ion binding]
1147161010258	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147161010259	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147161010260	metal-binding site [ion binding]
1147161010261	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147161010262	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1147161010263	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147161010264	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147161010265	metal-binding site [ion binding]
1147161010266	Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157
1147161010267	putative homodimer interface [polypeptide binding]; other site
1147161010268	putative homotetramer interface [polypeptide binding]; other site
1147161010269	allosteric switch controlling residues; other site
1147161010270	putative metal binding site [ion binding]; other site
1147161010271	putative homodimer-homodimer interface [polypeptide binding]; other site
1147161010272	putative oxidoreductase; Provisional; Region: PRK11579
1147161010273	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161010274	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161010275	azoreductase; Reviewed; Region: PRK00170
1147161010276	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147161010277	Predicted membrane protein [Function unknown]; Region: COG1289
1147161010278	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1147161010279	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1147161010280	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1147161010281	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161010282	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161010283	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1147161010284	classical (c) SDRs; Region: SDR_c; cd05233
1147161010285	NAD(P) binding site [chemical binding]; other site
1147161010286	active site
1147161010287	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1147161010288	SmpB-tmRNA interface; other site
1147161010289	ribonuclease R; Region: RNase_R; TIGR02063
1147161010290	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1147161010291	Cold shock protein domain; Region: CSP; smart00357
1147161010292	RNB domain; Region: RNB; pfam00773
1147161010293	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1147161010294	RNA binding site [nucleotide binding]; other site
1147161010295	Esterase/lipase [General function prediction only]; Region: COG1647
1147161010296	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147161010297	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161010298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161010299	salt bridge; other site
1147161010300	non-specific DNA binding site [nucleotide binding]; other site
1147161010301	sequence-specific DNA binding site [nucleotide binding]; other site
1147161010302	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161010303	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161010304	non-specific DNA binding site [nucleotide binding]; other site
1147161010305	salt bridge; other site
1147161010306	sequence-specific DNA binding site [nucleotide binding]; other site
1147161010307	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161010308	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161010309	non-specific DNA binding site [nucleotide binding]; other site
1147161010310	salt bridge; other site
1147161010311	sequence-specific DNA binding site [nucleotide binding]; other site
1147161010312	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161010313	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161010314	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1147161010315	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161010316	dimerization interface [polypeptide binding]; other site
1147161010317	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147161010318	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147161010319	dimer interface [polypeptide binding]; other site
1147161010320	putative CheW interface [polypeptide binding]; other site
1147161010321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010322	dimer interface [polypeptide binding]; other site
1147161010323	conserved gate region; other site
1147161010324	putative PBP binding loops; other site
1147161010325	ABC-ATPase subunit interface; other site
1147161010326	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1147161010327	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1147161010328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010329	dimer interface [polypeptide binding]; other site
1147161010330	conserved gate region; other site
1147161010331	putative PBP binding loops; other site
1147161010332	ABC-ATPase subunit interface; other site
1147161010333	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1147161010334	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1147161010335	Walker A/P-loop; other site
1147161010336	ATP binding site [chemical binding]; other site
1147161010337	Q-loop/lid; other site
1147161010338	ABC transporter signature motif; other site
1147161010339	Walker B; other site
1147161010340	D-loop; other site
1147161010341	H-loop/switch region; other site
1147161010342	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1147161010343	Predicted transcriptional regulators [Transcription]; Region: COG1510
1147161010344	MarR family; Region: MarR_2; pfam12802
1147161010345	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
1147161010346	antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033
1147161010347	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
1147161010348	Predicted integral membrane protein [Function unknown]; Region: COG5658
1147161010349	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1147161010350	SdpI/YhfL protein family; Region: SdpI; pfam13630
1147161010351	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161010352	dimerization interface [polypeptide binding]; other site
1147161010353	putative DNA binding site [nucleotide binding]; other site
1147161010354	putative Zn2+ binding site [ion binding]; other site
1147161010355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010356	dimer interface [polypeptide binding]; other site
1147161010357	conserved gate region; other site
1147161010358	putative PBP binding loops; other site
1147161010359	ABC-ATPase subunit interface; other site
1147161010360	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1147161010361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010362	dimer interface [polypeptide binding]; other site
1147161010363	conserved gate region; other site
1147161010364	putative PBP binding loops; other site
1147161010365	ABC-ATPase subunit interface; other site
1147161010366	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1147161010367	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1147161010368	Walker A/P-loop; other site
1147161010369	ATP binding site [chemical binding]; other site
1147161010370	Q-loop/lid; other site
1147161010371	ABC transporter signature motif; other site
1147161010372	Walker B; other site
1147161010373	D-loop; other site
1147161010374	H-loop/switch region; other site
1147161010375	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1147161010376	Predicted transcriptional regulators [Transcription]; Region: COG1510
1147161010377	MarR family; Region: MarR_2; pfam12802
1147161010378	membrane protein, MarC family; Region: TIGR00427
1147161010379	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1147161010380	pentamer interface [polypeptide binding]; other site
1147161010381	dodecaamer interface [polypeptide binding]; other site
1147161010382	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
1147161010383	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1147161010384	Double zinc ribbon; Region: DZR; pfam12773
1147161010385	Predicted membrane protein [Function unknown]; Region: COG4640
1147161010386	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1147161010387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161010388	Coenzyme A binding pocket [chemical binding]; other site
1147161010389	enolase; Provisional; Region: eno; PRK00077
1147161010390	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1147161010391	dimer interface [polypeptide binding]; other site
1147161010392	metal binding site [ion binding]; metal-binding site
1147161010393	substrate binding pocket [chemical binding]; other site
1147161010394	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1147161010395	phosphoglyceromutase; Provisional; Region: PRK05434
1147161010396	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1147161010397	triosephosphate isomerase; Provisional; Region: PRK14565
1147161010398	substrate binding site [chemical binding]; other site
1147161010399	dimer interface [polypeptide binding]; other site
1147161010400	catalytic triad [active]
1147161010401	Phosphoglycerate kinase; Region: PGK; pfam00162
1147161010402	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1147161010403	substrate binding site [chemical binding]; other site
1147161010404	hinge regions; other site
1147161010405	ADP binding site [chemical binding]; other site
1147161010406	catalytic site [active]
1147161010407	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1147161010408	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1147161010409	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1147161010410	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1147161010411	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1147161010412	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1147161010413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161010414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161010415	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161010416	DNA-binding site [nucleotide binding]; DNA binding site
1147161010417	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161010418	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
1147161010419	putative dimerization interface [polypeptide binding]; other site
1147161010420	putative ligand binding site [chemical binding]; other site
1147161010421	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1147161010422	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1147161010423	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1147161010424	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161010425	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161010426	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161010427	dimerization interface [polypeptide binding]; other site
1147161010428	EamA-like transporter family; Region: EamA; pfam00892
1147161010429	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1147161010430	EamA-like transporter family; Region: EamA; pfam00892
1147161010431	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1147161010432	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1147161010433	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1147161010434	active site
1147161010435	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1147161010436	iron-sulfur cluster-binding protein; Region: TIGR00273
1147161010437	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1147161010438	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1147161010439	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1147161010440	Cysteine-rich domain; Region: CCG; pfam02754
1147161010441	Cysteine-rich domain; Region: CCG; pfam02754
1147161010442	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161010443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161010444	active site
1147161010445	phosphorylation site [posttranslational modification]
1147161010446	intermolecular recognition site; other site
1147161010447	dimerization interface [polypeptide binding]; other site
1147161010448	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161010449	DNA binding residues [nucleotide binding]
1147161010450	dimerization interface [polypeptide binding]; other site
1147161010451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1147161010452	Histidine kinase; Region: HisKA_3; pfam07730
1147161010453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161010454	ATP binding site [chemical binding]; other site
1147161010455	Mg2+ binding site [ion binding]; other site
1147161010456	G-X-G motif; other site
1147161010457	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1147161010458	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1147161010459	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161010460	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161010461	Walker A/P-loop; other site
1147161010462	ATP binding site [chemical binding]; other site
1147161010463	Q-loop/lid; other site
1147161010464	ABC transporter signature motif; other site
1147161010465	Walker B; other site
1147161010466	D-loop; other site
1147161010467	H-loop/switch region; other site
1147161010468	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1147161010469	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1147161010470	catalytic site [active]
1147161010471	PAS domain S-box; Region: sensory_box; TIGR00229
1147161010472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161010473	putative active site [active]
1147161010474	heme pocket [chemical binding]; other site
1147161010475	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1147161010476	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1147161010477	Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867
1147161010478	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1147161010479	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1147161010480	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1147161010481	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1147161010482	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161010483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010484	dimer interface [polypeptide binding]; other site
1147161010485	conserved gate region; other site
1147161010486	putative PBP binding loops; other site
1147161010487	ABC-ATPase subunit interface; other site
1147161010488	TM2 domain; Region: TM2; pfam05154
1147161010489	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1147161010490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010491	dimer interface [polypeptide binding]; other site
1147161010492	conserved gate region; other site
1147161010493	ABC-ATPase subunit interface; other site
1147161010494	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1147161010495	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161010496	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161010497	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161010498	DNA binding site [nucleotide binding]
1147161010499	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1147161010500	putative dimerization interface [polypeptide binding]; other site
1147161010501	putative ligand binding site [chemical binding]; other site
1147161010502	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1147161010503	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161010504	DNA-binding site [nucleotide binding]; DNA binding site
1147161010505	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1147161010506	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1147161010507	L-lactate permease; Region: Lactate_perm; pfam02652
1147161010508	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1147161010509	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1147161010510	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1147161010511	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1147161010512	YvfG protein; Region: YvfG; pfam09628
1147161010513	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1147161010514	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1147161010515	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1147161010516	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147161010517	inhibitor-cofactor binding pocket; inhibition site
1147161010518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161010519	catalytic residue [active]
1147161010520	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1147161010521	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1147161010522	putative trimer interface [polypeptide binding]; other site
1147161010523	putative CoA binding site [chemical binding]; other site
1147161010524	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1147161010525	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
1147161010526	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161010527	active site
1147161010528	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1147161010529	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1147161010530	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161010531	active site
1147161010532	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161010533	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1147161010534	putative ADP-binding pocket [chemical binding]; other site
1147161010535	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161010536	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161010537	active site
1147161010538	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1147161010539	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161010540	putative ADP-binding pocket [chemical binding]; other site
1147161010541	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1147161010542	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1147161010543	NAD(P) binding site [chemical binding]; other site
1147161010544	homodimer interface [polypeptide binding]; other site
1147161010545	substrate binding site [chemical binding]; other site
1147161010546	active site
1147161010547	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
1147161010548	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147161010549	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1147161010550	Chain length determinant protein; Region: Wzz; cl15801
1147161010551	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147161010552	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147161010553	non-specific DNA binding site [nucleotide binding]; other site
1147161010554	salt bridge; other site
1147161010555	sequence-specific DNA binding site [nucleotide binding]; other site
1147161010556	Anti-repressor SinI; Region: SinI; pfam08671
1147161010557	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1147161010558	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1147161010559	substrate binding pocket [chemical binding]; other site
1147161010560	catalytic triad [active]
1147161010561	Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479
1147161010562	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1147161010563	aspartate racemase; Region: asp_race; TIGR00035
1147161010564	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1147161010565	Beta-lactamase; Region: Beta-lactamase; pfam00144
1147161010566	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1147161010567	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
1147161010568	active site
1147161010569	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1147161010570	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1147161010571	substrate binding [chemical binding]; other site
1147161010572	active site
1147161010573	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1147161010574	amino acid transporter; Region: 2A0306; TIGR00909
1147161010575	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161010576	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161010577	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1147161010578	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1147161010579	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1147161010580	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1147161010581	FAD binding domain; Region: FAD_binding_4; pfam01565
1147161010582	Berberine and berberine like; Region: BBE; pfam08031
1147161010583	Patatin [General function prediction only]; Region: COG3621
1147161010584	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213
1147161010585	active site
1147161010586	nucleophile elbow; other site
1147161010587	Clp protease; Region: CLP_protease; pfam00574
1147161010588	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1147161010589	oligomer interface [polypeptide binding]; other site
1147161010590	active site residues [active]
1147161010591	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1147161010592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161010593	motif II; other site
1147161010594	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1147161010595	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1147161010596	Ca binding site [ion binding]; other site
1147161010597	active site
1147161010598	catalytic site [active]
1147161010599	maltose phosphorylase; Provisional; Region: PRK13807
1147161010600	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1147161010601	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1147161010602	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1147161010603	Predicted integral membrane protein [Function unknown]; Region: COG5521
1147161010604	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1147161010605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010606	dimer interface [polypeptide binding]; other site
1147161010607	conserved gate region; other site
1147161010608	ABC-ATPase subunit interface; other site
1147161010609	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1147161010610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161010611	dimer interface [polypeptide binding]; other site
1147161010612	conserved gate region; other site
1147161010613	putative PBP binding loops; other site
1147161010614	ABC-ATPase subunit interface; other site
1147161010615	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1147161010616	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147161010617	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1147161010618	homodimer interface [polypeptide binding]; other site
1147161010619	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1147161010620	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1147161010621	active site
1147161010622	homodimer interface [polypeptide binding]; other site
1147161010623	catalytic site [active]
1147161010624	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161010625	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161010626	DNA binding site [nucleotide binding]
1147161010627	domain linker motif; other site
1147161010628	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1147161010629	ligand binding site [chemical binding]; other site
1147161010630	dimerization interface [polypeptide binding]; other site
1147161010631	TIGR00730 family protein; Region: TIGR00730
1147161010632	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
1147161010633	metal binding site [ion binding]; metal-binding site
1147161010634	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1147161010635	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1147161010636	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1147161010637	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1147161010638	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1147161010639	active site clefts [active]
1147161010640	zinc binding site [ion binding]; other site
1147161010641	dimer interface [polypeptide binding]; other site
1147161010642	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1147161010643	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1147161010644	dimerization interface [polypeptide binding]; other site
1147161010645	ligand binding site [chemical binding]; other site
1147161010646	NADP binding site [chemical binding]; other site
1147161010647	catalytic site [active]
1147161010648	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161010649	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161010650	Walker A/P-loop; other site
1147161010651	ATP binding site [chemical binding]; other site
1147161010652	Q-loop/lid; other site
1147161010653	ABC transporter signature motif; other site
1147161010654	Walker B; other site
1147161010655	D-loop; other site
1147161010656	H-loop/switch region; other site
1147161010657	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161010658	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1147161010659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161010660	ATP binding site [chemical binding]; other site
1147161010661	Mg2+ binding site [ion binding]; other site
1147161010662	G-X-G motif; other site
1147161010663	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161010664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161010665	active site
1147161010666	phosphorylation site [posttranslational modification]
1147161010667	intermolecular recognition site; other site
1147161010668	dimerization interface [polypeptide binding]; other site
1147161010669	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161010670	DNA binding site [nucleotide binding]
1147161010671	Lysis protein; Region: Lysis_col; pfam02402
1147161010672	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1147161010673	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1147161010674	dimerization domain swap beta strand [polypeptide binding]; other site
1147161010675	regulatory protein interface [polypeptide binding]; other site
1147161010676	active site
1147161010677	regulatory phosphorylation site [posttranslational modification]; other site
1147161010678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1147161010679	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1147161010680	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1147161010681	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1147161010682	phosphate binding site [ion binding]; other site
1147161010683	putative substrate binding pocket [chemical binding]; other site
1147161010684	dimer interface [polypeptide binding]; other site
1147161010685	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
1147161010686	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1147161010687	putative active site [active]
1147161010688	nucleotide binding site [chemical binding]; other site
1147161010689	nudix motif; other site
1147161010690	putative metal binding site [ion binding]; other site
1147161010691	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1147161010692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147161010693	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161010694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1147161010695	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161010696	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161010697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161010698	binding surface
1147161010699	TPR motif; other site
1147161010700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161010701	TPR motif; other site
1147161010702	binding surface
1147161010703	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161010704	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161010705	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161010706	Walker A/P-loop; other site
1147161010707	ATP binding site [chemical binding]; other site
1147161010708	Q-loop/lid; other site
1147161010709	ABC transporter signature motif; other site
1147161010710	Walker B; other site
1147161010711	D-loop; other site
1147161010712	H-loop/switch region; other site
1147161010713	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1147161010714	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1147161010715	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1147161010716	metal binding site [ion binding]; metal-binding site
1147161010717	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1147161010718	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1147161010719	substrate binding site [chemical binding]; other site
1147161010720	glutamase interaction surface [polypeptide binding]; other site
1147161010721	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1147161010722	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1147161010723	catalytic residues [active]
1147161010724	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1147161010725	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1147161010726	putative active site [active]
1147161010727	oxyanion strand; other site
1147161010728	catalytic triad [active]
1147161010729	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1147161010730	putative active site pocket [active]
1147161010731	4-fold oligomerization interface [polypeptide binding]; other site
1147161010732	metal binding residues [ion binding]; metal-binding site
1147161010733	3-fold/trimer interface [polypeptide binding]; other site
1147161010734	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1147161010735	histidinol dehydrogenase; Region: hisD; TIGR00069
1147161010736	NAD binding site [chemical binding]; other site
1147161010737	dimerization interface [polypeptide binding]; other site
1147161010738	product binding site; other site
1147161010739	substrate binding site [chemical binding]; other site
1147161010740	zinc binding site [ion binding]; other site
1147161010741	catalytic residues [active]
1147161010742	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1147161010743	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1147161010744	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
1147161010745	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1147161010746	dimer interface [polypeptide binding]; other site
1147161010747	motif 1; other site
1147161010748	active site
1147161010749	motif 2; other site
1147161010750	motif 3; other site
1147161010751	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1147161010752	putative active site [active]
1147161010753	Pectate lyase; Region: Pectate_lyase; pfam03211
1147161010754	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1147161010755	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1147161010756	CoA binding site [chemical binding]; other site
1147161010757	active site
1147161010758	pyrophosphatase PpaX; Provisional; Region: PRK13288
1147161010759	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161010760	motif II; other site
1147161010761	Nucleoside recognition; Region: Gate; pfam07670
1147161010762	Nucleoside recognition; Region: Gate; pfam07670
1147161010763	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1147161010764	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1147161010765	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1147161010766	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1147161010767	Hpr binding site; other site
1147161010768	active site
1147161010769	homohexamer subunit interaction site [polypeptide binding]; other site
1147161010770	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1147161010771	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1147161010772	active site
1147161010773	dimer interface [polypeptide binding]; other site
1147161010774	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1147161010775	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1147161010776	active site
1147161010777	trimer interface [polypeptide binding]; other site
1147161010778	allosteric site; other site
1147161010779	active site lid [active]
1147161010780	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1147161010781	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147161010782	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161010783	DNA-binding site [nucleotide binding]; DNA binding site
1147161010784	UTRA domain; Region: UTRA; pfam07702
1147161010785	Lamin Tail Domain; Region: LTD; pfam00932
1147161010786	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
1147161010787	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161010788	putative active site [active]
1147161010789	putative metal binding site [ion binding]; other site
1147161010790	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161010791	MarR family; Region: MarR; pfam01047
1147161010792	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1147161010793	Cytochrome P450; Region: p450; cl12078
1147161010794	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161010795	MarR family; Region: MarR; pfam01047
1147161010796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161010797	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161010798	putative substrate translocation pore; other site
1147161010799	Predicted membrane protein [Function unknown]; Region: COG1950
1147161010800	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1147161010801	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1147161010802	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1147161010803	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1147161010804	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1147161010805	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1147161010806	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1147161010807	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1147161010808	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1147161010809	excinuclease ABC subunit B; Provisional; Region: PRK05298
1147161010810	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161010811	ATP binding site [chemical binding]; other site
1147161010812	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161010813	nucleotide binding region [chemical binding]; other site
1147161010814	ATP-binding site [chemical binding]; other site
1147161010815	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1147161010816	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
1147161010817	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1147161010818	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
1147161010819	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1147161010820	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161010821	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161010822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161010823	putative substrate translocation pore; other site
1147161010824	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1147161010825	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1147161010826	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1147161010827	C-terminal peptidase (prc); Region: prc; TIGR00225
1147161010828	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1147161010829	protein binding site [polypeptide binding]; other site
1147161010830	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1147161010831	Catalytic dyad [active]
1147161010832	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147161010833	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1147161010834	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1147161010835	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1147161010836	ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292
1147161010837	Walker A/P-loop; other site
1147161010838	ATP binding site [chemical binding]; other site
1147161010839	Q-loop/lid; other site
1147161010840	ABC transporter signature motif; other site
1147161010841	Walker B; other site
1147161010842	D-loop; other site
1147161010843	H-loop/switch region; other site
1147161010844	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1147161010845	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1147161010846	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161010847	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161010848	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161010849	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161010850	peptide chain release factor 2; Provisional; Region: PRK06746
1147161010851	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1147161010852	RF-1 domain; Region: RF-1; pfam00472
1147161010853	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1147161010854	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1147161010855	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1147161010856	nucleotide binding region [chemical binding]; other site
1147161010857	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1147161010858	ATP-binding site [chemical binding]; other site
1147161010859	SEC-C motif; Region: SEC-C; pfam02810
1147161010860	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1147161010861	30S subunit binding site; other site
1147161010862	Flagellar protein FliT; Region: FliT; pfam05400
1147161010863	flagellar biosynthetic protein FliS; Region: fliS; TIGR00208
1147161010864	flagellar capping protein; Validated; Region: fliD; PRK07737
1147161010865	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1147161010866	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1147161010867	flagellar protein FlaG; Provisional; Region: PRK07738
1147161010868	flagellin; Provisional; Region: PRK12804
1147161010869	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1147161010870	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1147161010871	carbon storage regulator; Provisional; Region: PRK01712
1147161010872	flagellar assembly protein FliW; Provisional; Region: PRK13285
1147161010873	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
1147161010874	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1147161010875	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1147161010876	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
1147161010877	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147161010878	FlgN protein; Region: FlgN; pfam05130
1147161010879	Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747
1147161010880	flagellar operon protein TIGR03826; Region: YvyF
1147161010881	comF family protein; Region: comF; TIGR00201
1147161010882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161010883	active site
1147161010884	Late competence development protein ComFB; Region: ComFB; pfam10719
1147161010885	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1147161010886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161010887	ATP binding site [chemical binding]; other site
1147161010888	putative Mg++ binding site [ion binding]; other site
1147161010889	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161010890	nucleotide binding region [chemical binding]; other site
1147161010891	ATP-binding site [chemical binding]; other site
1147161010892	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147161010893	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147161010894	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161010895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161010896	active site
1147161010897	phosphorylation site [posttranslational modification]
1147161010898	intermolecular recognition site; other site
1147161010899	dimerization interface [polypeptide binding]; other site
1147161010900	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161010901	DNA binding residues [nucleotide binding]
1147161010902	dimerization interface [polypeptide binding]; other site
1147161010903	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161010904	Histidine kinase; Region: HisKA_3; pfam07730
1147161010905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161010906	ATP binding site [chemical binding]; other site
1147161010907	Mg2+ binding site [ion binding]; other site
1147161010908	G-X-G motif; other site
1147161010909	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
1147161010910	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1147161010911	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1147161010912	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1147161010913	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1147161010914	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1147161010915	Mg++ binding site [ion binding]; other site
1147161010916	putative catalytic motif [active]
1147161010917	substrate binding site [chemical binding]; other site
1147161010918	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1147161010919	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161010920	putative homodimer interface [polypeptide binding]; other site
1147161010921	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161010922	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161010923	active site
1147161010924	Chain length determinant protein; Region: Wzz; pfam02706
1147161010925	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
1147161010926	O-Antigen ligase; Region: Wzy_C; pfam04932
1147161010927	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1147161010928	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1147161010929	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1147161010930	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1147161010931	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161010932	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1147161010933	colanic acid exporter; Provisional; Region: PRK10459
1147161010934	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1147161010935	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1147161010936	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1147161010937	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1147161010938	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147161010939	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147161010940	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147161010941	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1147161010942	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1147161010943	active site
1147161010944	metal binding site [ion binding]; metal-binding site
1147161010945	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147161010946	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1147161010947	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147161010948	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147161010949	Stage II sporulation protein; Region: SpoIID; pfam08486
1147161010950	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1147161010951	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
1147161010952	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
1147161010953	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1147161010954	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1147161010955	active site
1147161010956	homodimer interface [polypeptide binding]; other site
1147161010957	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1147161010958	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1147161010959	active site
1147161010960	tetramer interface; other site
1147161010961	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161010962	active site
1147161010963	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1147161010964	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1147161010965	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161010966	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161010967	active site
1147161010968	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1147161010969	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1147161010970	Walker A/P-loop; other site
1147161010971	ATP binding site [chemical binding]; other site
1147161010972	Q-loop/lid; other site
1147161010973	ABC transporter signature motif; other site
1147161010974	Walker B; other site
1147161010975	D-loop; other site
1147161010976	H-loop/switch region; other site
1147161010977	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1147161010978	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1147161010979	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1147161010980	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1147161010981	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1147161010982	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1147161010983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147161010984	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
1147161010985	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1147161010986	active site
1147161010987	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1147161010988	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1147161010989	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1147161010990	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1147161010991	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1147161010992	Bacterial SH3 domain; Region: SH3_3; pfam08239
1147161010993	Lysozyme subfamily 2; Region: LYZ2; smart00047
1147161010994	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1147161010995	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1147161010996	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147161010997	Spore germination protein; Region: Spore_permease; pfam03845
1147161010998	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147161010999	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147161011000	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1147161011001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011002	putative substrate translocation pore; other site
1147161011003	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1147161011004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161011005	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1147161011006	active site
1147161011007	motif I; other site
1147161011008	motif II; other site
1147161011009	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1147161011010	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161011011	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161011012	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161011013	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161011014	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147161011015	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147161011016	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
1147161011017	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1147161011018	putative active site [active]
1147161011019	putative metal binding site [ion binding]; other site
1147161011020	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
1147161011021	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
1147161011022	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147161011023	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1147161011024	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161011025	DNA binding site [nucleotide binding]
1147161011026	domain linker motif; other site
1147161011027	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1147161011028	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1147161011029	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1147161011030	substrate binding site [chemical binding]; other site
1147161011031	dimer interface [polypeptide binding]; other site
1147161011032	ATP binding site [chemical binding]; other site
1147161011033	D-ribose pyranase; Provisional; Region: PRK11797
1147161011034	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1147161011035	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1147161011036	Walker A/P-loop; other site
1147161011037	ATP binding site [chemical binding]; other site
1147161011038	Q-loop/lid; other site
1147161011039	ABC transporter signature motif; other site
1147161011040	Walker B; other site
1147161011041	D-loop; other site
1147161011042	H-loop/switch region; other site
1147161011043	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1147161011044	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1147161011045	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1147161011046	TM-ABC transporter signature motif; other site
1147161011047	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1147161011048	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1147161011049	ligand binding site [chemical binding]; other site
1147161011050	dimerization interface [polypeptide binding]; other site
1147161011051	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1147161011052	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1147161011053	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1147161011054	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1147161011055	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147161011056	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
1147161011057	acetolactate synthase; Reviewed; Region: PRK08617
1147161011058	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1147161011059	PYR/PP interface [polypeptide binding]; other site
1147161011060	dimer interface [polypeptide binding]; other site
1147161011061	TPP binding site [chemical binding]; other site
1147161011062	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147161011063	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1147161011064	TPP-binding site [chemical binding]; other site
1147161011065	dimer interface [polypeptide binding]; other site
1147161011066	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1147161011067	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161011068	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
1147161011069	putative dimerization interface [polypeptide binding]; other site
1147161011070	putative substrate binding pocket [chemical binding]; other site
1147161011071	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1147161011072	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1147161011073	transmembrane helices; other site
1147161011074	CotH protein; Region: CotH; pfam08757
1147161011075	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1147161011076	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
1147161011077	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1147161011078	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1147161011079	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1147161011080	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161011081	putative DNA binding site [nucleotide binding]; other site
1147161011082	putative Zn2+ binding site [ion binding]; other site
1147161011083	AsnC family; Region: AsnC_trans_reg; pfam01037
1147161011084	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1147161011085	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1147161011086	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1147161011087	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147161011088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161011089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161011090	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161011091	dimerization interface [polypeptide binding]; other site
1147161011092	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1147161011093	Active_site [active]
1147161011094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
1147161011095	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1147161011096	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1147161011097	YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431
1147161011098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1147161011099	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1147161011100	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1147161011101	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1147161011102	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1147161011103	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1147161011104	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1147161011105	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147161011106	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1147161011107	Chain length determinant protein; Region: Wzz; cl15801
1147161011108	SWIM zinc finger; Region: SWIM; pfam04434
1147161011109	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1147161011110	SNF2 Helicase protein; Region: DUF3670; pfam12419
1147161011111	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147161011112	ATP binding site [chemical binding]; other site
1147161011113	putative Mg++ binding site [ion binding]; other site
1147161011114	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161011115	nucleotide binding region [chemical binding]; other site
1147161011116	ATP-binding site [chemical binding]; other site
1147161011117	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161011118	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1147161011119	active site
1147161011120	motif I; other site
1147161011121	motif II; other site
1147161011122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161011123	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147161011124	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1147161011125	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1147161011126	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1147161011127	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1147161011128	dimer interface [polypeptide binding]; other site
1147161011129	ssDNA binding site [nucleotide binding]; other site
1147161011130	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161011131	YwpF-like protein; Region: YwpF; pfam14183
1147161011132	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1147161011133	active site
1147161011134	catalytic site [active]
1147161011135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161011136	active site
1147161011137	dimerization interface [polypeptide binding]; other site
1147161011138	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1147161011139	Histidine kinase; Region: His_kinase; pfam06580
1147161011140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161011141	ATP binding site [chemical binding]; other site
1147161011142	Mg2+ binding site [ion binding]; other site
1147161011143	G-X-G motif; other site
1147161011144	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
1147161011145	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1147161011146	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1147161011147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161011148	binding surface
1147161011149	TPR motif; other site
1147161011150	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1147161011151	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1147161011152	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1147161011153	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1147161011154	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1147161011155	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147161011156	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1147161011157	MreB and similar proteins; Region: MreB_like; cd10225
1147161011158	nucleotide binding site [chemical binding]; other site
1147161011159	Mg binding site [ion binding]; other site
1147161011160	putative protofilament interaction site [polypeptide binding]; other site
1147161011161	RodZ interaction site [polypeptide binding]; other site
1147161011162	Stage III sporulation protein D; Region: SpoIIID; pfam12116
1147161011163	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161011164	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161011165	putative Zn2+ binding site [ion binding]; other site
1147161011166	putative DNA binding site [nucleotide binding]; other site
1147161011167	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161011168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011169	putative substrate translocation pore; other site
1147161011170	Right handed beta helix region; Region: Beta_helix; pfam13229
1147161011171	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
1147161011172	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1147161011173	Na binding site [ion binding]; other site
1147161011174	putative substrate binding site [chemical binding]; other site
1147161011175	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011176	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161011177	putative substrate translocation pore; other site
1147161011178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011179	Isochorismatase family; Region: Isochorismatase; pfam00857
1147161011180	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1147161011181	catalytic triad [active]
1147161011182	conserved cis-peptide bond; other site
1147161011183	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1147161011184	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1147161011185	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1147161011186	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1147161011187	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1147161011188	active site
1147161011189	VanZ like family; Region: VanZ; pfam04892
1147161011190	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147161011191	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147161011192	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1147161011193	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161011194	Coenzyme A binding pocket [chemical binding]; other site
1147161011195	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1147161011196	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1147161011197	DNA binding residues [nucleotide binding]
1147161011198	dimer interface [polypeptide binding]; other site
1147161011199	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1147161011200	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1147161011201	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1147161011202	NAD binding site [chemical binding]; other site
1147161011203	substrate binding site [chemical binding]; other site
1147161011204	putative active site [active]
1147161011205	Predicted transcriptional regulator [Transcription]; Region: COG1959
1147161011206	Transcriptional regulator; Region: Rrf2; pfam02082
1147161011207	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1147161011208	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1147161011209	subunit interactions [polypeptide binding]; other site
1147161011210	active site
1147161011211	flap region; other site
1147161011212	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1147161011213	gamma-beta subunit interface [polypeptide binding]; other site
1147161011214	alpha-beta subunit interface [polypeptide binding]; other site
1147161011215	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1147161011216	alpha-gamma subunit interface [polypeptide binding]; other site
1147161011217	beta-gamma subunit interface [polypeptide binding]; other site
1147161011218	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1147161011219	CsbD-like; Region: CsbD; pfam05532
1147161011220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161011221	binding surface
1147161011222	TPR motif; other site
1147161011223	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161011224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161011225	binding surface
1147161011226	TPR motif; other site
1147161011227	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1147161011228	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161011229	FeS/SAM binding site; other site
1147161011230	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1147161011231	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1147161011232	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
1147161011233	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1147161011234	metal ion-dependent adhesion site (MIDAS); other site
1147161011235	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
1147161011236	metal ion-dependent adhesion site (MIDAS); other site
1147161011237	stage II sporulation protein D; Region: spore_II_D; TIGR02870
1147161011238	Stage II sporulation protein; Region: SpoIID; pfam08486
1147161011239	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1147161011240	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1147161011241	hinge; other site
1147161011242	active site
1147161011243	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
1147161011244	Predicted membrane protein [Function unknown]; Region: COG4836
1147161011245	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1147161011246	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1147161011247	gamma subunit interface [polypeptide binding]; other site
1147161011248	epsilon subunit interface [polypeptide binding]; other site
1147161011249	LBP interface [polypeptide binding]; other site
1147161011250	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1147161011251	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1147161011252	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1147161011253	alpha subunit interaction interface [polypeptide binding]; other site
1147161011254	Walker A motif; other site
1147161011255	ATP binding site [chemical binding]; other site
1147161011256	Walker B motif; other site
1147161011257	inhibitor binding site; inhibition site
1147161011258	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1147161011259	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1147161011260	core domain interface [polypeptide binding]; other site
1147161011261	delta subunit interface [polypeptide binding]; other site
1147161011262	epsilon subunit interface [polypeptide binding]; other site
1147161011263	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1147161011264	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1147161011265	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1147161011266	beta subunit interaction interface [polypeptide binding]; other site
1147161011267	Walker A motif; other site
1147161011268	ATP binding site [chemical binding]; other site
1147161011269	Walker B motif; other site
1147161011270	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1147161011271	ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145
1147161011272	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1147161011273	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1147161011274	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1147161011275	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1147161011276	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1147161011277	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1147161011278	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1147161011279	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147161011280	active site
1147161011281	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1147161011282	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1147161011283	dimer interface [polypeptide binding]; other site
1147161011284	active site
1147161011285	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1147161011286	folate binding site [chemical binding]; other site
1147161011287	hypothetical protein; Provisional; Region: PRK13690
1147161011288	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1147161011289	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1147161011290	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1147161011291	active site
1147161011292	Predicted membrane protein [Function unknown]; Region: COG1971
1147161011293	Domain of unknown function DUF; Region: DUF204; pfam02659
1147161011294	Domain of unknown function DUF; Region: DUF204; pfam02659
1147161011295	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1147161011296	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1147161011297	N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246
1147161011298	stage II sporulation protein R; Region: spore_II_R; TIGR02837
1147161011299	HemK family putative methylases; Region: hemK_fam; TIGR00536
1147161011300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161011301	S-adenosylmethionine binding site [chemical binding]; other site
1147161011302	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1147161011303	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1147161011304	RF-1 domain; Region: RF-1; pfam00472
1147161011305	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1147161011306	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161011307	putative metal binding site [ion binding]; other site
1147161011308	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
1147161011309	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1147161011310	DNA binding residues [nucleotide binding]
1147161011311	he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946
1147161011312	malate dehydrogenase; Provisional; Region: PRK13529
1147161011313	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1147161011314	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1147161011315	NAD(P) binding site [chemical binding]; other site
1147161011316	thymidine kinase; Provisional; Region: PRK04296
1147161011317	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1147161011318	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1147161011319	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1147161011320	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1147161011321	RNA binding site [nucleotide binding]; other site
1147161011322	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1147161011323	multimer interface [polypeptide binding]; other site
1147161011324	Walker A motif; other site
1147161011325	ATP binding site [chemical binding]; other site
1147161011326	Walker B motif; other site
1147161011327	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1147161011328	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1147161011329	putative active site [active]
1147161011330	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1147161011331	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1147161011332	hinge; other site
1147161011333	active site
1147161011334	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1147161011335	active site
1147161011336	intersubunit interactions; other site
1147161011337	catalytic residue [active]
1147161011338	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1147161011339	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1147161011340	intersubunit interface [polypeptide binding]; other site
1147161011341	active site
1147161011342	zinc binding site [ion binding]; other site
1147161011343	Na+ binding site [ion binding]; other site
1147161011344	Response regulator receiver domain; Region: Response_reg; pfam00072
1147161011345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161011346	active site
1147161011347	phosphorylation site [posttranslational modification]
1147161011348	intermolecular recognition site; other site
1147161011349	dimerization interface [polypeptide binding]; other site
1147161011350	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1147161011351	CTP synthetase; Validated; Region: pyrG; PRK05380
1147161011352	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1147161011353	Catalytic site [active]
1147161011354	active site
1147161011355	UTP binding site [chemical binding]; other site
1147161011356	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1147161011357	active site
1147161011358	putative oxyanion hole; other site
1147161011359	catalytic triad [active]
1147161011360	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1147161011361	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1147161011362	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1147161011363	FAD binding site [chemical binding]; other site
1147161011364	homotetramer interface [polypeptide binding]; other site
1147161011365	substrate binding pocket [chemical binding]; other site
1147161011366	catalytic base [active]
1147161011367	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
1147161011368	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1147161011369	Cysteine-rich domain; Region: CCG; pfam02754
1147161011370	Cysteine-rich domain; Region: CCG; pfam02754
1147161011371	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1147161011372	putative active site [active]
1147161011373	catalytic site [active]
1147161011374	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1147161011375	PLD-like domain; Region: PLDc_2; pfam13091
1147161011376	putative active site [active]
1147161011377	catalytic site [active]
1147161011378	UV damage endonuclease UvdE; Region: uvde; TIGR00629
1147161011379	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1147161011380	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1147161011381	folate binding site [chemical binding]; other site
1147161011382	NADP+ binding site [chemical binding]; other site
1147161011383	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147161011384	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161011385	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1147161011386	Walker A/P-loop; other site
1147161011387	ATP binding site [chemical binding]; other site
1147161011388	Q-loop/lid; other site
1147161011389	ABC transporter signature motif; other site
1147161011390	Walker B; other site
1147161011391	D-loop; other site
1147161011392	H-loop/switch region; other site
1147161011393	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1147161011394	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1147161011395	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1147161011396	putative active site [active]
1147161011397	catalytic site [active]
1147161011398	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1147161011399	putative active site [active]
1147161011400	catalytic site [active]
1147161011401	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1147161011402	nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684
1147161011403	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1147161011404	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
1147161011405	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1147161011406	[4Fe-4S] binding site [ion binding]; other site
1147161011407	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1147161011408	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1147161011409	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1147161011410	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1147161011411	molybdopterin cofactor binding site; other site
1147161011412	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147161011413	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1147161011414	ligand binding site [chemical binding]; other site
1147161011415	flexible hinge region; other site
1147161011416	YwiC-like protein; Region: YwiC; pfam14256
1147161011417	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147161011418	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147161011419	ligand binding site [chemical binding]; other site
1147161011420	flexible hinge region; other site
1147161011421	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147161011422	putative switch regulator; other site
1147161011423	non-specific DNA interactions [nucleotide binding]; other site
1147161011424	DNA binding site [nucleotide binding]
1147161011425	sequence specific DNA binding site [nucleotide binding]; other site
1147161011426	putative cAMP binding site [chemical binding]; other site
1147161011427	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1147161011428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011429	putative substrate translocation pore; other site
1147161011430	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1147161011431	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1147161011432	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1147161011433	active site
1147161011434	HIGH motif; other site
1147161011435	KMSK motif region; other site
1147161011436	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1147161011437	tRNA binding surface [nucleotide binding]; other site
1147161011438	anticodon binding site; other site
1147161011439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
1147161011440	Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420
1147161011441	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1147161011442	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1147161011443	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161011444	FeS/SAM binding site; other site
1147161011445	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1147161011446	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1147161011447	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161011448	Walker A/P-loop; other site
1147161011449	ATP binding site [chemical binding]; other site
1147161011450	Q-loop/lid; other site
1147161011451	ABC transporter signature motif; other site
1147161011452	Walker B; other site
1147161011453	D-loop; other site
1147161011454	H-loop/switch region; other site
1147161011455	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1147161011456	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1147161011457	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1147161011458	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1147161011459	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1147161011460	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1147161011461	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1147161011462	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1147161011463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1147161011464	binding surface
1147161011465	TPR motif; other site
1147161011466	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1147161011467	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161011468	TPR motif; other site
1147161011469	binding surface
1147161011470	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161011471	Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131
1147161011472	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1147161011473	putative deacylase active site [active]
1147161011474	agmatinase; Region: agmatinase; TIGR01230
1147161011475	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1147161011476	putative active site [active]
1147161011477	Mn binding site [ion binding]; other site
1147161011478	spermidine synthase; Provisional; Region: PRK00811
1147161011479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161011480	Transglycosylase; Region: Transgly; pfam00912
1147161011481	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1147161011482	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1147161011483	YwhD family; Region: YwhD; pfam08741
1147161011484	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1147161011485	Peptidase family M50; Region: Peptidase_M50; pfam02163
1147161011486	active site
1147161011487	putative substrate binding region [chemical binding]; other site
1147161011488	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1147161011489	active site 1 [active]
1147161011490	dimer interface [polypeptide binding]; other site
1147161011491	hexamer interface [polypeptide binding]; other site
1147161011492	active site 2 [active]
1147161011493	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161011494	MarR family; Region: MarR; pfam01047
1147161011495	MarR family; Region: MarR_2; cl17246
1147161011496	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
1147161011497	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1147161011498	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1147161011499	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1147161011500	active site
1147161011501	dimer interface [polypeptide binding]; other site
1147161011502	motif 1; other site
1147161011503	motif 2; other site
1147161011504	motif 3; other site
1147161011505	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1147161011506	anticodon binding site; other site
1147161011507	benzoate transport; Region: 2A0115; TIGR00895
1147161011508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011509	putative substrate translocation pore; other site
1147161011510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011511	Rrf2 family protein; Region: rrf2_super; TIGR00738
1147161011512	Transcriptional regulator; Region: Rrf2; pfam02082
1147161011513	Uncharacterized conserved protein [Function unknown]; Region: COG3465
1147161011514	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1147161011515	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147161011516	Zn2+ binding site [ion binding]; other site
1147161011517	Mg2+ binding site [ion binding]; other site
1147161011518	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1147161011519	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1147161011520	EamA-like transporter family; Region: EamA; pfam00892
1147161011521	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1147161011522	EamA-like transporter family; Region: EamA; pfam00892
1147161011523	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1147161011524	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161011525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161011526	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1147161011527	putative dimerization interface [polypeptide binding]; other site
1147161011528	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1147161011529	putative heme peroxidase; Provisional; Region: PRK12276
1147161011530	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1147161011531	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1147161011532	putative NAD(P) binding site [chemical binding]; other site
1147161011533	putative active site [active]
1147161011534	transaminase; Reviewed; Region: PRK08068
1147161011535	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147161011536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161011537	homodimer interface [polypeptide binding]; other site
1147161011538	catalytic residue [active]
1147161011539	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147161011540	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
1147161011541	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1147161011542	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1147161011543	classical (c) SDRs; Region: SDR_c; cd05233
1147161011544	NAD(P) binding site [chemical binding]; other site
1147161011545	active site
1147161011546	Cupin domain; Region: Cupin_2; pfam07883
1147161011547	Cupin domain; Region: Cupin_2; pfam07883
1147161011548	Prephenate dehydratase; Region: PDT; pfam00800
1147161011549	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161011550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011551	putative substrate translocation pore; other site
1147161011552	S-methylmethionine transporter; Provisional; Region: PRK11387
1147161011553	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
1147161011554	putative metal binding site [ion binding]; other site
1147161011555	putative dimer interface [polypeptide binding]; other site
1147161011556	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1147161011557	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1147161011558	Glutamate binding site [chemical binding]; other site
1147161011559	homodimer interface [polypeptide binding]; other site
1147161011560	NAD binding site [chemical binding]; other site
1147161011561	catalytic residues [active]
1147161011562	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1147161011563	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1147161011564	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1147161011565	NAD(P) binding site [chemical binding]; other site
1147161011566	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1147161011567	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1147161011568	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1147161011569	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1147161011570	NADP binding site [chemical binding]; other site
1147161011571	active site
1147161011572	putative substrate binding site [chemical binding]; other site
1147161011573	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1147161011574	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
1147161011575	NAD binding site [chemical binding]; other site
1147161011576	substrate binding site [chemical binding]; other site
1147161011577	homodimer interface [polypeptide binding]; other site
1147161011578	active site
1147161011579	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1147161011580	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1147161011581	substrate binding site; other site
1147161011582	tetramer interface; other site
1147161011583	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
1147161011584	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1147161011585	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
1147161011586	ligand binding site; other site
1147161011587	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
1147161011588	NeuB family; Region: NeuB; pfam03102
1147161011589	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1147161011590	NeuB binding interface [polypeptide binding]; other site
1147161011591	putative substrate binding site [chemical binding]; other site
1147161011592	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1147161011593	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161011594	Coenzyme A binding pocket [chemical binding]; other site
1147161011595	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1147161011596	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147161011597	inhibitor-cofactor binding pocket; inhibition site
1147161011598	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161011599	catalytic residue [active]
1147161011600	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1147161011601	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1147161011602	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161011603	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161011604	active site
1147161011605	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
1147161011606	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1147161011607	Permease family; Region: Xan_ur_permease; pfam00860
1147161011608	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1147161011609	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1147161011610	NAD(P) binding site [chemical binding]; other site
1147161011611	catalytic residues [active]
1147161011612	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1147161011613	ligand binding site [chemical binding]; other site
1147161011614	active site
1147161011615	UGI interface [polypeptide binding]; other site
1147161011616	catalytic site [active]
1147161011617	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147161011618	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147161011619	active site
1147161011620	Predicted transcriptional regulators [Transcription]; Region: COG1695
1147161011621	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147161011622	putative DNA binding site [nucleotide binding]; other site
1147161011623	putative Zn2+ binding site [ion binding]; other site
1147161011624	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1147161011625	dimer interface [polypeptide binding]; other site
1147161011626	substrate binding site [chemical binding]; other site
1147161011627	ATP binding site [chemical binding]; other site
1147161011628	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1147161011629	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1147161011630	substrate binding [chemical binding]; other site
1147161011631	active site
1147161011632	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1147161011633	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1147161011634	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161011635	active site turn [active]
1147161011636	phosphorylation site [posttranslational modification]
1147161011637	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161011638	formate/nitrite transporter; Region: fnt; TIGR00790
1147161011639	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1147161011640	CAT RNA binding domain; Region: CAT_RBD; smart01061
1147161011641	PRD domain; Region: PRD; pfam00874
1147161011642	PRD domain; Region: PRD; pfam00874
1147161011643	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1147161011644	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1147161011645	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1147161011646	putative active site [active]
1147161011647	catalytic triad [active]
1147161011648	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1147161011649	PA/protease domain interface [polypeptide binding]; other site
1147161011650	putative integrin binding motif; other site
1147161011651	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1147161011652	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1147161011653	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1147161011654	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1147161011655	Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171
1147161011656	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1147161011657	dimer interface [polypeptide binding]; other site
1147161011658	FMN binding site [chemical binding]; other site
1147161011659	NADPH bind site [chemical binding]; other site
1147161011660	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
1147161011661	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
1147161011662	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1147161011663	Subunit I/III interface [polypeptide binding]; other site
1147161011664	Subunit III/IV interface [polypeptide binding]; other site
1147161011665	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1147161011666	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1147161011667	D-pathway; other site
1147161011668	Putative ubiquinol binding site [chemical binding]; other site
1147161011669	Low-spin heme (heme b) binding site [chemical binding]; other site
1147161011670	Putative water exit pathway; other site
1147161011671	Binuclear center (heme o3/CuB) [ion binding]; other site
1147161011672	K-pathway; other site
1147161011673	Putative proton exit pathway; other site
1147161011674	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1147161011675	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1147161011676	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1147161011677	Predicted membrane protein [Function unknown]; Region: COG2261
1147161011678	Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468
1147161011679	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1147161011680	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1147161011681	galactokinase; Provisional; Region: PRK05322
1147161011682	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1147161011683	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1147161011684	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1147161011685	Predicted membrane protein [Function unknown]; Region: COG2246
1147161011686	GtrA-like protein; Region: GtrA; pfam04138
1147161011687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161011688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161011689	Anti-repressor SinI; Region: SinI; pfam08671
1147161011690	Predicted membrane protein [Function unknown]; Region: COG3162
1147161011691	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1147161011692	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1147161011693	Na binding site [ion binding]; other site
1147161011694	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1147161011695	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1147161011696	catalytic residues [active]
1147161011697	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1147161011698	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1147161011699	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1147161011700	Imelysin; Region: Peptidase_M75; pfam09375
1147161011701	FTR1 family protein; Region: TIGR00145
1147161011702	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1147161011703	thiamine phosphate binding site [chemical binding]; other site
1147161011704	active site
1147161011705	pyrophosphate binding site [ion binding]; other site
1147161011706	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1147161011707	substrate binding site [chemical binding]; other site
1147161011708	multimerization interface [polypeptide binding]; other site
1147161011709	ATP binding site [chemical binding]; other site
1147161011710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161011711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161011712	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1147161011713	putative dimerization interface [polypeptide binding]; other site
1147161011714	holin-like protein; Validated; Region: PRK01658
1147161011715	TIGR00659 family protein; Region: TIGR00659
1147161011716	sugar efflux transporter; Region: 2A0120; TIGR00899
1147161011717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011718	putative substrate translocation pore; other site
1147161011719	conserved hypothetical protein; Region: TIGR03833
1147161011720	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1147161011721	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1147161011722	putative RNA binding site [nucleotide binding]; other site
1147161011723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161011724	S-adenosylmethionine binding site [chemical binding]; other site
1147161011725	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161011726	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1147161011727	active site
1147161011728	metal binding site [ion binding]; metal-binding site
1147161011729	Protein of unknown function (DUF2711); Region: DUF2711; pfam10924
1147161011730	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1147161011731	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
1147161011732	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1147161011733	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1147161011734	active site
1147161011735	catalytic residues [active]
1147161011736	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1147161011737	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161011738	active site turn [active]
1147161011739	phosphorylation site [posttranslational modification]
1147161011740	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161011741	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1147161011742	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1147161011743	PRD domain; Region: PRD; pfam00874
1147161011744	PRD domain; Region: PRD; pfam00874
1147161011745	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1147161011746	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1147161011747	Ligand binding site; other site
1147161011748	metal-binding site
1147161011749	Predicted integral membrane protein [Function unknown]; Region: COG5522
1147161011750	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161011751	MarR family; Region: MarR; pfam01047
1147161011752	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1147161011753	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1147161011754	active site
1147161011755	HIGH motif; other site
1147161011756	dimer interface [polypeptide binding]; other site
1147161011757	KMSKS motif; other site
1147161011758	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147161011759	RNA binding surface [nucleotide binding]; other site
1147161011760	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1147161011761	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1147161011762	PA/protease domain interface [polypeptide binding]; other site
1147161011763	putative integrin binding motif; other site
1147161011764	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1147161011765	Peptidase family M28; Region: Peptidase_M28; pfam04389
1147161011766	metal binding site [ion binding]; metal-binding site
1147161011767	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1147161011768	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1147161011769	synthetase active site [active]
1147161011770	NTP binding site [chemical binding]; other site
1147161011771	metal binding site [ion binding]; metal-binding site
1147161011772	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1147161011773	UbiA prenyltransferase family; Region: UbiA; pfam01040
1147161011774	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1147161011775	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
1147161011776	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1147161011777	acyl-activating enzyme (AAE) consensus motif; other site
1147161011778	AMP binding site [chemical binding]; other site
1147161011779	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1147161011780	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1147161011781	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1147161011782	DltD N-terminal region; Region: DltD_N; pfam04915
1147161011783	DltD central region; Region: DltD_M; pfam04918
1147161011784	DltD C-terminal region; Region: DltD_C; pfam04914
1147161011785	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1147161011786	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
1147161011787	putative NAD(P) binding site [chemical binding]; other site
1147161011788	active site
1147161011789	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1147161011790	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1147161011791	homodimer interface [polypeptide binding]; other site
1147161011792	substrate-cofactor binding pocket; other site
1147161011793	catalytic residue [active]
1147161011794	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1147161011795	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1147161011796	NAD binding site [chemical binding]; other site
1147161011797	sugar binding site [chemical binding]; other site
1147161011798	divalent metal binding site [ion binding]; other site
1147161011799	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161011800	dimer interface [polypeptide binding]; other site
1147161011801	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1147161011802	methionine cluster; other site
1147161011803	active site
1147161011804	phosphorylation site [posttranslational modification]
1147161011805	metal binding site [ion binding]; metal-binding site
1147161011806	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1147161011807	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
1147161011808	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1147161011809	active site
1147161011810	P-loop; other site
1147161011811	phosphorylation site [posttranslational modification]
1147161011812	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1147161011813	HTH domain; Region: HTH_11; pfam08279
1147161011814	Mga helix-turn-helix domain; Region: Mga; pfam05043
1147161011815	PRD domain; Region: PRD; pfam00874
1147161011816	PRD domain; Region: PRD; pfam00874
1147161011817	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1147161011818	active site
1147161011819	P-loop; other site
1147161011820	phosphorylation site [posttranslational modification]
1147161011821	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1147161011822	active site
1147161011823	phosphorylation site [posttranslational modification]
1147161011824	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1147161011825	active site
1147161011826	DNA binding site [nucleotide binding]
1147161011827	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1147161011828	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1147161011829	tetramer interface [polypeptide binding]; other site
1147161011830	heme binding pocket [chemical binding]; other site
1147161011831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011832	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161011833	putative substrate translocation pore; other site
1147161011834	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147161011835	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147161011836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161011837	Walker A/P-loop; other site
1147161011838	ATP binding site [chemical binding]; other site
1147161011839	Q-loop/lid; other site
1147161011840	ABC transporter signature motif; other site
1147161011841	Walker B; other site
1147161011842	D-loop; other site
1147161011843	H-loop/switch region; other site
1147161011844	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1147161011845	Exoribonuclease II [Transcription]; Region: Rnb; COG4776
1147161011846	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
1147161011847	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147161011848	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161011849	DNA binding residues [nucleotide binding]
1147161011850	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1147161011851	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1147161011852	Na binding site [ion binding]; other site
1147161011853	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1147161011854	putative substrate binding site [chemical binding]; other site
1147161011855	putative ATP binding site [chemical binding]; other site
1147161011856	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1147161011857	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161011858	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1147161011859	Walker A/P-loop; other site
1147161011860	ATP binding site [chemical binding]; other site
1147161011861	Q-loop/lid; other site
1147161011862	ABC transporter signature motif; other site
1147161011863	Walker B; other site
1147161011864	D-loop; other site
1147161011865	H-loop/switch region; other site
1147161011866	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1147161011867	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147161011868	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147161011869	ATP binding site [chemical binding]; other site
1147161011870	Q-loop/lid; other site
1147161011871	ABC transporter signature motif; other site
1147161011872	Walker B; other site
1147161011873	D-loop; other site
1147161011874	H-loop/switch region; other site
1147161011875	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
1147161011876	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1147161011877	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1147161011878	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1147161011879	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1147161011880	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1147161011881	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1147161011882	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1147161011883	putative active site [active]
1147161011884	putative metal binding site [ion binding]; other site
1147161011885	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1147161011886	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1147161011887	Walker A/P-loop; other site
1147161011888	ATP binding site [chemical binding]; other site
1147161011889	Q-loop/lid; other site
1147161011890	ABC transporter signature motif; other site
1147161011891	Walker B; other site
1147161011892	D-loop; other site
1147161011893	H-loop/switch region; other site
1147161011894	TOBE domain; Region: TOBE; pfam03459
1147161011895	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1147161011896	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147161011897	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
1147161011898	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1147161011899	NAD(P) binding site [chemical binding]; other site
1147161011900	catalytic residues [active]
1147161011901	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147161011902	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161011903	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147161011904	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147161011905	ykkC-yxkD; BSU6051_3884010
1147161011906	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1147161011907	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1147161011908	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1147161011909	UDP-glucose 4-epimerase; Region: PLN02240
1147161011910	NAD binding site [chemical binding]; other site
1147161011911	homodimer interface [polypeptide binding]; other site
1147161011912	active site
1147161011913	substrate binding site [chemical binding]; other site
1147161011914	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1147161011915	substrate binding site [chemical binding]; other site
1147161011916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161011917	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161011918	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147161011919	dimerization interface [polypeptide binding]; other site
1147161011920	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147161011921	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1147161011922	Histidine kinase; Region: HisKA_3; pfam07730
1147161011923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161011924	ATP binding site [chemical binding]; other site
1147161011925	Mg2+ binding site [ion binding]; other site
1147161011926	G-X-G motif; other site
1147161011927	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147161011928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161011929	active site
1147161011930	phosphorylation site [posttranslational modification]
1147161011931	intermolecular recognition site; other site
1147161011932	dimerization interface [polypeptide binding]; other site
1147161011933	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147161011934	DNA binding residues [nucleotide binding]
1147161011935	dimerization interface [polypeptide binding]; other site
1147161011936	peptidase T; Region: peptidase-T; TIGR01882
1147161011937	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1147161011938	metal binding site [ion binding]; metal-binding site
1147161011939	dimer interface [polypeptide binding]; other site
1147161011940	Uncharacterized conserved protein [Function unknown]; Region: COG4894
1147161011941	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1147161011942	substrate binding site [chemical binding]; other site
1147161011943	THF binding site; other site
1147161011944	zinc-binding site [ion binding]; other site
1147161011945	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1147161011946	substrate binding site [chemical binding]; other site
1147161011947	THF binding site; other site
1147161011948	zinc-binding site [ion binding]; other site
1147161011949	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1147161011950	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
1147161011951	NAD binding site [chemical binding]; other site
1147161011952	homotetramer interface [polypeptide binding]; other site
1147161011953	homodimer interface [polypeptide binding]; other site
1147161011954	substrate binding site [chemical binding]; other site
1147161011955	active site
1147161011956	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1147161011957	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1147161011958	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1147161011959	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1147161011960	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1147161011961	S-adenosylmethionine binding site [chemical binding]; other site
1147161011962	nucleoside transporter; Region: nupC; TIGR00804
1147161011963	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1147161011964	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1147161011965	hydroperoxidase II; Provisional; Region: katE; PRK11249
1147161011966	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1147161011967	tetramer interface [polypeptide binding]; other site
1147161011968	heme binding pocket [chemical binding]; other site
1147161011969	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1147161011970	domain interactions; other site
1147161011971	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
1147161011972	Citrate transporter; Region: CitMHS; pfam03600
1147161011973	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1147161011974	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1147161011975	active site
1147161011976	active site
1147161011977	catalytic residues [active]
1147161011978	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1147161011979	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1147161011980	PRD domain; Region: PRD; pfam00874
1147161011981	PRD domain; Region: PRD; pfam00874
1147161011982	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1147161011983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161011984	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1147161011985	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1147161011986	ATP binding site [chemical binding]; other site
1147161011987	Mg++ binding site [ion binding]; other site
1147161011988	motif III; other site
1147161011989	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147161011990	nucleotide binding region [chemical binding]; other site
1147161011991	ATP-binding site [chemical binding]; other site
1147161011992	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
1147161011993	RNA binding site [nucleotide binding]; other site
1147161011994	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1147161011995	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1147161011996	active site
1147161011997	catalytic triad [active]
1147161011998	YxiJ-like protein; Region: YxiJ; pfam14176
1147161011999	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
1147161012000	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1147161012001	RHS Repeat; Region: RHS_repeat; pfam05593
1147161012002	RHS Repeat; Region: RHS_repeat; pfam05593
1147161012003	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1147161012004	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1147161012005	RHS Repeat; Region: RHS_repeat; pfam05593
1147161012006	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
1147161012007	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1147161012008	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1147161012009	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147161012010	EamA-like transporter family; Region: EamA; pfam00892
1147161012011	EamA-like transporter family; Region: EamA; pfam00892
1147161012012	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1147161012013	Ligand Binding Site [chemical binding]; other site
1147161012014	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1147161012015	beta-galactosidase; Region: BGL; TIGR03356
1147161012016	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1147161012017	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1147161012018	active site turn [active]
1147161012019	phosphorylation site [posttranslational modification]
1147161012020	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1147161012021	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1147161012022	HPr interaction site; other site
1147161012023	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1147161012024	active site
1147161012025	phosphorylation site [posttranslational modification]
1147161012026	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
1147161012027	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1147161012028	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1147161012029	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1147161012030	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1147161012031	substrate binding site [chemical binding]; other site
1147161012032	active site
1147161012033	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
1147161012034	hexamer interface [polypeptide binding]; other site
1147161012035	RNA binding site [nucleotide binding]; other site
1147161012036	Histidine-zinc binding site [chemical binding]; other site
1147161012037	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1147161012038	active sites [active]
1147161012039	tetramer interface [polypeptide binding]; other site
1147161012040	urocanate hydratase; Provisional; Region: PRK05414
1147161012041	imidazolonepropionase; Validated; Region: PRK09356
1147161012042	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1147161012043	active site
1147161012044	Agmatinase-like family; Region: Agmatinase-like; cd09990
1147161012045	agmatinase; Region: agmatinase; TIGR01230
1147161012046	active site
1147161012047	oligomer interface [polypeptide binding]; other site
1147161012048	Mn binding site [ion binding]; other site
1147161012049	S-methylmethionine transporter; Provisional; Region: PRK11387
1147161012050	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1147161012051	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1147161012052	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1147161012053	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1147161012054	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1147161012055	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1147161012056	Nucleoside recognition; Region: Gate; pfam07670
1147161012057	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1147161012058	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1147161012059	intersubunit interface [polypeptide binding]; other site
1147161012060	active site
1147161012061	catalytic residue [active]
1147161012062	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1147161012063	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147161012064	DNA binding residues [nucleotide binding]
1147161012065	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1147161012066	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1147161012067	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1147161012068	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1147161012069	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
1147161012070	MmgE/PrpD family; Region: MmgE_PrpD; pfam03972
1147161012071	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1147161012072	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1147161012073	metal binding site [ion binding]; metal-binding site
1147161012074	dimer interface [polypeptide binding]; other site
1147161012075	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1147161012076	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1147161012077	Walker A/P-loop; other site
1147161012078	ATP binding site [chemical binding]; other site
1147161012079	Q-loop/lid; other site
1147161012080	ABC transporter signature motif; other site
1147161012081	Walker B; other site
1147161012082	D-loop; other site
1147161012083	H-loop/switch region; other site
1147161012084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147161012085	dimer interface [polypeptide binding]; other site
1147161012086	conserved gate region; other site
1147161012087	putative PBP binding loops; other site
1147161012088	ABC-ATPase subunit interface; other site
1147161012089	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1147161012090	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147161012091	substrate binding pocket [chemical binding]; other site
1147161012092	membrane-bound complex binding site; other site
1147161012093	hinge residues; other site
1147161012094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161012095	Coenzyme A binding pocket [chemical binding]; other site
1147161012096	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1147161012097	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1147161012098	active site
1147161012099	non-prolyl cis peptide bond; other site
1147161012100	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1147161012101	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1147161012102	active site
1147161012103	sugar phosphate phosphatase; Provisional; Region: PRK10513
1147161012104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161012105	active site
1147161012106	motif I; other site
1147161012107	motif II; other site
1147161012108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147161012109	Protein of unknown function (DUF3255); Region: DUF3255; pfam11631
1147161012110	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1147161012111	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1147161012112	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1147161012113	putative ligand binding residues [chemical binding]; other site
1147161012114	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1147161012115	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147161012116	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147161012117	Walker A/P-loop; other site
1147161012118	ATP binding site [chemical binding]; other site
1147161012119	Q-loop/lid; other site
1147161012120	ABC transporter signature motif; other site
1147161012121	Walker B; other site
1147161012122	D-loop; other site
1147161012123	H-loop/switch region; other site
1147161012124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147161012125	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1147161012126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161012127	ATP binding site [chemical binding]; other site
1147161012128	Mg2+ binding site [ion binding]; other site
1147161012129	G-X-G motif; other site
1147161012130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161012131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161012132	active site
1147161012133	phosphorylation site [posttranslational modification]
1147161012134	intermolecular recognition site; other site
1147161012135	dimerization interface [polypeptide binding]; other site
1147161012136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161012137	DNA binding site [nucleotide binding]
1147161012138	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1147161012139	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1147161012140	intersubunit interface [polypeptide binding]; other site
1147161012141	active site
1147161012142	zinc binding site [ion binding]; other site
1147161012143	Na+ binding site [ion binding]; other site
1147161012144	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1147161012145	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1147161012146	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1147161012147	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1147161012148	DNA interaction; other site
1147161012149	Metal-binding active site; metal-binding site
1147161012150	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147161012151	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147161012152	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147161012153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161012155	putative substrate translocation pore; other site
1147161012156	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1147161012157	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1147161012158	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1147161012159	PYR/PP interface [polypeptide binding]; other site
1147161012160	dimer interface [polypeptide binding]; other site
1147161012161	TPP binding site [chemical binding]; other site
1147161012162	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147161012163	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1147161012164	TPP-binding site; other site
1147161012165	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1147161012166	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1147161012167	substrate binding site [chemical binding]; other site
1147161012168	ATP binding site [chemical binding]; other site
1147161012169	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1147161012170	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1147161012171	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1147161012172	tetrameric interface [polypeptide binding]; other site
1147161012173	NAD binding site [chemical binding]; other site
1147161012174	catalytic residues [active]
1147161012175	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147161012176	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1147161012177	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1147161012178	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147161012179	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147161012180	active site
1147161012181	catalytic tetrad [active]
1147161012182	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
1147161012183	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1147161012184	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012185	putative substrate translocation pore; other site
1147161012186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012187	heat shock protein 90; Provisional; Region: PRK05218
1147161012188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161012189	ATP binding site [chemical binding]; other site
1147161012190	Mg2+ binding site [ion binding]; other site
1147161012191	G-X-G motif; other site
1147161012192	short chain dehydrogenase; Validated; Region: PRK08589
1147161012193	classical (c) SDRs; Region: SDR_c; cd05233
1147161012194	NAD(P) binding site [chemical binding]; other site
1147161012195	active site
1147161012196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161012197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161012198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161012199	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1147161012200	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
1147161012201	NAD(P) binding site [chemical binding]; other site
1147161012202	catalytic residues [active]
1147161012203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161012204	Coenzyme A binding pocket [chemical binding]; other site
1147161012205	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1147161012206	Cupin-like domain; Region: Cupin_8; pfam13621
1147161012207	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1147161012208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161012209	S-adenosylmethionine binding site [chemical binding]; other site
1147161012210	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1147161012211	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1147161012212	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1147161012213	active site
1147161012214	dimer interface [polypeptide binding]; other site
1147161012215	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1147161012216	Ligand Binding Site [chemical binding]; other site
1147161012217	Molecular Tunnel; other site
1147161012218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012219	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161012220	putative substrate translocation pore; other site
1147161012221	FOG: WD40-like repeat [Function unknown]; Region: COG1520
1147161012222	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1147161012223	active site
1147161012224	Trp docking motif [polypeptide binding]; other site
1147161012225	RDD family; Region: RDD; pfam06271
1147161012226	Predicted membrane protein [Function unknown]; Region: COG2311
1147161012227	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1147161012228	Cupin domain; Region: Cupin_2; pfam07883
1147161012229	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1147161012230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147161012231	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147161012232	short chain dehydrogenase; Provisional; Region: PRK07109
1147161012233	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1147161012234	putative NAD(P) binding site [chemical binding]; other site
1147161012235	active site
1147161012236	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161012237	MarR family; Region: MarR; pfam01047
1147161012238	LrgA family; Region: LrgA; cl00608
1147161012239	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1147161012240	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1147161012241	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1147161012242	Glycerate kinase family; Region: Gly_kinase; pfam02595
1147161012243	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1147161012244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161012245	DNA-binding site [nucleotide binding]; DNA binding site
1147161012246	FCD domain; Region: FCD; pfam07729
1147161012247	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1147161012248	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1147161012249	N- and C-terminal domain interface [polypeptide binding]; other site
1147161012250	active site
1147161012251	catalytic site [active]
1147161012252	metal binding site [ion binding]; metal-binding site
1147161012253	carbohydrate binding site [chemical binding]; other site
1147161012254	ATP binding site [chemical binding]; other site
1147161012255	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1147161012256	gluconate transporter; Region: gntP; TIGR00791
1147161012257	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873
1147161012258	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1147161012259	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1147161012260	peroxiredoxin; Region: AhpC; TIGR03137
1147161012261	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1147161012262	dimer interface [polypeptide binding]; other site
1147161012263	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1147161012264	catalytic triad [active]
1147161012265	peroxidatic and resolving cysteines [active]
1147161012266	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1147161012267	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1147161012268	catalytic residue [active]
1147161012269	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1147161012270	catalytic residues [active]
1147161012271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147161012272	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147161012273	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1147161012274	beta-galactosidase; Region: BGL; TIGR03356
1147161012275	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1147161012276	HPr interaction site; other site
1147161012277	active site
1147161012278	phosphorylation site [posttranslational modification]
1147161012279	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147161012280	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147161012281	DNA-binding site [nucleotide binding]; DNA binding site
1147161012282	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1147161012283	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1147161012284	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1147161012285	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1147161012286	Walker A/P-loop; other site
1147161012287	ATP binding site [chemical binding]; other site
1147161012288	Q-loop/lid; other site
1147161012289	ABC transporter signature motif; other site
1147161012290	Walker B; other site
1147161012291	D-loop; other site
1147161012292	H-loop/switch region; other site
1147161012293	peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078
1147161012294	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147161012295	FeS/SAM binding site; other site
1147161012296	exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077
1147161012297	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
1147161012298	Predicted ATPase [General function prediction only]; Region: COG5293
1147161012299	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
1147161012300	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147161012301	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
1147161012302	putative active site [active]
1147161012303	putative metal binding site [ion binding]; other site
1147161012304	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1147161012305	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1147161012306	CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129
1147161012307	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1147161012308	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1147161012309	NAD binding site [chemical binding]; other site
1147161012310	catalytic Zn binding site [ion binding]; other site
1147161012311	structural Zn binding site [ion binding]; other site
1147161012312	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1147161012313	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1147161012314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161012315	Coenzyme A binding pocket [chemical binding]; other site
1147161012316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161012317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147161012318	binding surface
1147161012319	TPR motif; other site
1147161012320	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147161012321	Arginase family; Region: Arginase; cd09989
1147161012322	agmatinase; Region: agmatinase; TIGR01230
1147161012323	active site
1147161012324	Mn binding site [ion binding]; other site
1147161012325	oligomer interface [polypeptide binding]; other site
1147161012326	S-methylmethionine transporter; Provisional; Region: PRK11387
1147161012327	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1147161012328	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147161012329	inhibitor-cofactor binding pocket; inhibition site
1147161012330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147161012331	catalytic residue [active]
1147161012332	PAS domain; Region: PAS; smart00091
1147161012333	PAS domain; Region: PAS_9; pfam13426
1147161012334	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1147161012335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147161012336	Walker A motif; other site
1147161012337	ATP binding site [chemical binding]; other site
1147161012338	Walker B motif; other site
1147161012339	arginine finger; other site
1147161012340	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1147161012341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161012342	ATP binding site [chemical binding]; other site
1147161012343	G-X-G motif; other site
1147161012344	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1147161012345	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1147161012346	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1147161012347	protein binding site [polypeptide binding]; other site
1147161012348	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1147161012349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
1147161012350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1147161012351	YycH protein; Region: YycH; pfam07435
1147161012352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1147161012353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147161012354	dimerization interface [polypeptide binding]; other site
1147161012355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147161012356	putative active site [active]
1147161012357	heme pocket [chemical binding]; other site
1147161012358	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147161012359	dimer interface [polypeptide binding]; other site
1147161012360	phosphorylation site [posttranslational modification]
1147161012361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147161012362	ATP binding site [chemical binding]; other site
1147161012363	Mg2+ binding site [ion binding]; other site
1147161012364	G-X-G motif; other site
1147161012365	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147161012366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147161012367	active site
1147161012368	phosphorylation site [posttranslational modification]
1147161012369	intermolecular recognition site; other site
1147161012370	dimerization interface [polypeptide binding]; other site
1147161012371	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147161012372	DNA binding site [nucleotide binding]
1147161012373	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1147161012374	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1147161012375	GDP-binding site [chemical binding]; other site
1147161012376	ACT binding site; other site
1147161012377	IMP binding site; other site
1147161012378	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161012379	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1147161012380	active site
1147161012381	replicative DNA helicase; Provisional; Region: PRK05748
1147161012382	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1147161012383	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1147161012384	Walker A motif; other site
1147161012385	ATP binding site [chemical binding]; other site
1147161012386	Walker B motif; other site
1147161012387	DNA binding loops [nucleotide binding]
1147161012388	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
1147161012389	YycC-like protein; Region: YycC; pfam14174
1147161012390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012391	cyanate transporter; Region: CynX; TIGR00896
1147161012392	putative substrate translocation pore; other site
1147161012393	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1147161012394	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1147161012395	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1147161012396	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1147161012397	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1147161012398	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1147161012399	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1147161012400	diguanylate cyclase; Region: GGDEF; smart00267
1147161012401	DHH family; Region: DHH; pfam01368
1147161012402	DHHA1 domain; Region: DHHA1; pfam02272
1147161012403	Predicted membrane protein [Function unknown]; Region: COG4241
1147161012404	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1147161012405	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147161012406	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147161012407	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1147161012408	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1147161012409	DHHA2 domain; Region: DHHA2; pfam02833
1147161012410	ANTAR domain; Region: ANTAR; cl04297
1147161012411	D-galactonate transporter; Region: 2A0114; TIGR00893
1147161012412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012413	putative substrate translocation pore; other site
1147161012414	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1147161012415	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
1147161012416	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
1147161012417	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1147161012418	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147161012419	Walker A/P-loop; other site
1147161012420	ATP binding site [chemical binding]; other site
1147161012421	Q-loop/lid; other site
1147161012422	ABC transporter signature motif; other site
1147161012423	Walker B; other site
1147161012424	D-loop; other site
1147161012425	H-loop/switch region; other site
1147161012426	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
1147161012427	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1147161012428	SnoaL-like domain; Region: SnoaL_3; pfam13474
1147161012429	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1147161012430	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1147161012431	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1147161012432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012433	putative substrate translocation pore; other site
1147161012434	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147161012435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147161012436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147161012437	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1147161012438	putative dimerization interface [polypeptide binding]; other site
1147161012439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161012440	Coenzyme A binding pocket [chemical binding]; other site
1147161012441	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147161012442	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147161012443	MarR family; Region: MarR; pfam01047
1147161012444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161012445	Coenzyme A binding pocket [chemical binding]; other site
1147161012446	Predicted membrane protein [Function unknown]; Region: COG2364
1147161012447	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1147161012448	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147161012449	Coenzyme A binding pocket [chemical binding]; other site
1147161012450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1147161012451	RibD C-terminal domain; Region: RibD_C; cl17279
1147161012452	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1147161012453	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147161012454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012455	putative substrate translocation pore; other site
1147161012456	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1147161012457	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1147161012458	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147161012459	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1147161012460	DNA binding residues [nucleotide binding]
1147161012461	putative dimer interface [polypeptide binding]; other site
1147161012462	EamA-like transporter family; Region: EamA; pfam00892
1147161012463	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1147161012464	EamA-like transporter family; Region: EamA; pfam00892
1147161012465	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1147161012466	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1147161012467	catalytic residues [active]
1147161012468	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1147161012469	CAAX protease self-immunity; Region: Abi; pfam02517
1147161012470	benzoate transport; Region: 2A0115; TIGR00895
1147161012471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012472	putative substrate translocation pore; other site
1147161012473	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147161012474	maltose O-acetyltransferase; Provisional; Region: PRK10092
1147161012475	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1147161012476	active site
1147161012477	substrate binding site [chemical binding]; other site
1147161012478	trimer interface [polypeptide binding]; other site
1147161012479	CoA binding site [chemical binding]; other site
1147161012480	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147161012481	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1147161012482	putative metal binding site [ion binding]; other site
1147161012483	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1147161012484	DNA binding site [nucleotide binding]
1147161012485	domain linker motif; other site
1147161012486	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1147161012487	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1147161012488	putative dimerization interface [polypeptide binding]; other site
1147161012489	putative ligand binding site [chemical binding]; other site
1147161012490	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1147161012491	active site
1147161012492	putative catalytic site [active]
1147161012493	DNA binding site [nucleotide binding]
1147161012494	putative phosphate binding site [ion binding]; other site
1147161012495	metal binding site A [ion binding]; metal-binding site
1147161012496	AP binding site [nucleotide binding]; other site
1147161012497	metal binding site B [ion binding]; metal-binding site
1147161012498	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1147161012499	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1147161012500	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1147161012501	dimer interface [polypeptide binding]; other site
1147161012502	ssDNA binding site [nucleotide binding]; other site
1147161012503	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147161012504	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1147161012505	GTP-binding protein YchF; Reviewed; Region: PRK09601
1147161012506	YchF GTPase; Region: YchF; cd01900
1147161012507	G1 box; other site
1147161012508	GTP/Mg2+ binding site [chemical binding]; other site
1147161012509	Switch I region; other site
1147161012510	G2 box; other site
1147161012511	Switch II region; other site
1147161012512	G3 box; other site
1147161012513	G4 box; other site
1147161012514	G5 box; other site
1147161012515	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1147161012516	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1147161012517	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1147161012518	putative [4Fe-4S] binding site [ion binding]; other site
1147161012519	putative molybdopterin cofactor binding site [chemical binding]; other site
1147161012520	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1147161012521	molybdopterin cofactor binding site; other site
1147161012522	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1147161012523	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1147161012524	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
1147161012525	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1147161012526	ParB-like nuclease domain; Region: ParB; smart00470
1147161012527	KorB domain; Region: KorB; pfam08535
1147161012528	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1147161012529	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147161012530	P-loop; other site
1147161012531	Magnesium ion binding site [ion binding]; other site
1147161012532	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147161012533	Magnesium ion binding site [ion binding]; other site
1147161012534	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147161012535	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1147161012536	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1147161012537	ParB-like nuclease domain; Region: ParB; smart00470
1147161012538	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1147161012539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147161012540	S-adenosylmethionine binding site [chemical binding]; other site
1147161012541	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1147161012542	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1147161012543	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1147161012544	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1147161012545	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1147161012546	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1147161012547	G1 box; other site
1147161012548	GTP/Mg2+ binding site [chemical binding]; other site
1147161012549	Switch I region; other site
1147161012550	G2 box; other site
1147161012551	Switch II region; other site
1147161012552	G3 box; other site
1147161012553	G4 box; other site
1147161012554	G5 box; other site
1147161012555	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1147161012556	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1147161012557	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1147161012558	G-X-X-G motif; other site
1147161012559	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1147161012560	RxxxH motif; other site
1147161012561	OxaA-like protein precursor; Validated; Region: PRK02944
1147161012562	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1147161012563	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1147161012564	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399